format-version: 1.2 data-version: releases/2019-03-19 subsetdef: gocheck_do_not_annotate "Term not to be used for direct annotation" subsetdef: gocheck_do_not_manually_annotate "Term not to be used for direct manual annotation" subsetdef: goslim_agr "AGR slim" subsetdef: goslim_aspergillus "Aspergillus GO slim" subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_chembl "ChEMBL protein targets summary" subsetdef: goslim_flybase_ribbon "FlyBase Drosophila GO ribbon slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_metagenomics "Metagenomics GO slim" subsetdef: goslim_mouse "Mouse GO slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_synapse "synapse GO slim" subsetdef: goslim_yeast "Yeast GO slim" synonymtypedef: syngo_official_label "label approved by the SynGO project" synonymtypedef: systematic_synonym "Systematic synonym" EXACT default-namespace: gene_ontology remark: cvs version: use data-version remark: Includes Ontology(OntologyID(OntologyIRI())) [Axioms: 18 Logical Axioms: 0] ontology: go [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production of new individuals that contain some portion of genetic material inherited from one or more parent organisms." [GOC:go_curators, GOC:isa_complete, GOC:jl, ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: obsolete ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. synonym: "ribosomal chaperone activity" EXACT [] is_obsolete: true consider: GO:0042254 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0000006 name: high-affinity zinc transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of zinc ions (Zn2+) from one side of a membrane to the other, probably powered by proton motive force. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] synonym: "high affinity zinc uptake transmembrane transporter activity" EXACT [] synonym: "high-affinity zinc uptake transmembrane transporter activity" RELATED [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000008 name: obsolete thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. synonym: "thioredoxin" EXACT [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->6) linkage." [GOC:mcc, PMID:2644248] synonym: "1,6-alpha-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.232 xref: reactome:R-HSA-449718 "Addition of a third mannose to the N-glycan precursor by ALG2" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = all-trans-heptaprenyl diphosphate + diphosphate." [KEGG:R05612, RHEA:20836] xref: KEGG:R05612 xref: RHEA:20836 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] synonym: "single-stranded DNA specific endodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific endodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732] subset: goslim_metagenomics synonym: "enolase complex" EXACT [] is_a: GO:0044445 ! cytosolic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] xref: EC:3.2.1.108 xref: MetaCyc:LACTASE-RXN xref: reactome:R-HSA-189062 "lactose + H2O => D-glucose + D-galactose" xref: RHEA:10076 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a DNA metabolic process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732] is_a: GO:0051052 ! regulation of DNA metabolic process relationship: regulates GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination relationship: regulates GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: obsolete negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it describes a substrate-specific process. synonym: "negative regulation of recombination within rDNA repeats" EXACT [] is_obsolete: true consider: GO:0045950 [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "The cell cycle process in which the distance is lengthened between poles of the mitotic spindle. Mitotic spindle elongation begins during mitotic prophase and ends during mitotic anaphase B." [GOC:mtg_cell_cycle, GOC:vw] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732] synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] synonym: "malt sugar biosynthesis" EXACT [] synonym: "malt sugar biosynthetic process" EXACT [] synonym: "maltose anabolism" EXACT [] synonym: "maltose biosynthesis" EXACT [] synonym: "maltose formation" EXACT [] synonym: "maltose synthesis" EXACT [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732] synonym: "malt sugar catabolic process" EXACT [] synonym: "malt sugar catabolism" EXACT [] synonym: "maltose breakdown" EXACT [] synonym: "maltose degradation" EXACT [] synonym: "maltose hydrolysis" NARROW [] xref: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->2) linkage." [GOC:mcc, PMID:10521541] xref: reactome:R-HSA-446187 "ALG11 transfers the fourth and fifth Man to the N-glycan precursor" xref: reactome:R-HSA-446215 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)6 (PP-Dol)1" xref: reactome:R-HSA-446216 "ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] synonym: "50S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "60S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000028 name: ribosomal small subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] synonym: "30S ribosomal subunit assembly" NARROW [GOC:mah] synonym: "40S ribosomal subunit assembly" NARROW [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0042255 ! ribosome assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai, GOC:cjm] xref: reactome:R-HSA-162797 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> mannose (a1) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" xref: reactome:R-HSA-162830 "glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose(al1-4)glucosaminyl-acyl-PI + dolichol phosphate" xref: reactome:R-HSA-446198 "ALG12 transfers Man to N-glycan precursor (GlcNAc)2 (Man)7 (PP-Dol)1" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues." [GOC:ai] synonym: "cell wall mannoprotein anabolism" EXACT [] synonym: "cell wall mannoprotein biosynthesis" EXACT [] synonym: "cell wall mannoprotein formation" EXACT [] synonym: "cell wall mannoprotein synthesis" EXACT [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:mcc, PMID:10521541] xref: reactome:R-HSA-446188 "ALG3 transfers Man to N-glycan precursor (GlcNAc)2 (Man)5 (PP-Dol)1" xref: reactome:R-HSA-446208 "Addition of a second mannose to the N-glycan precursor by ALG2" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: MetaCyc:ADENINE-DEAMINASE-RXN xref: RHEA:23688 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [GOC:curators, ISBN:0198506732] synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function def: "Binding an acyl group and presenting it for processing or offloading to a cognate enzyme. Covalently binds the acyl group via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The acyl carrier protein (ACP) presents substrates to enzymes involved in fatty acid biosynthesis or in polyketide secondary metabolite biosynthesis." [CHEBI:22221, GOC:jl, GOC:vw] synonym: "ACP phosphopantetheine attachment site binding involved in fatty acid biosynthetic process" EXACT [] is_a: GO:0044620 ! ACP phosphopantetheine attachment site binding is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0000038 name: very long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:hjd] synonym: "very long chain fatty acid metabolic process" EXACT [GOC:bf] synonym: "very-long-chain fatty acid metabolic process" EXACT [] synonym: "very-long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: obsolete plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. synonym: "plasma membrane long-chain fatty acid transporter" EXACT [] is_obsolete: true consider: GO:0005324 consider: GO:0005886 [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732] synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000044 name: obsolete ascorbate stabilization namespace: biological_process def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "ascorbate stabilization" EXACT [] synonym: "vitamin C stabilization" EXACT [] is_obsolete: true [Term] id: GO:0000045 name: autophagosome assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [GOC:autophagy, PMID:9412464] synonym: "autophagic vacuole assembly" EXACT [GOC:autophagy] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0070925 ! organelle assembly is_a: GO:1905037 ! autophagosome organization [Term] id: GO:0000047 name: obsolete Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "Rieske iron-sulfur protein" EXACT [] synonym: "Rieske iron-sulphur protein" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: reactome:R-HSA-156912 "Peptide transfer from P-site tRNA to the A-site tRNA" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function alt_id: GO:0000946 def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] synonym: "base pairing with tRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "The sequence of reactions by which arginine is synthesized from ornithine, then cleaved to yield urea and regenerate ornithine. The overall reaction equation is NH3 + CO2 + aspartate + 3 ATP + 2 H2O = urea + fumarate + 2 ADP + 2 phosphate + AMP + diphosphate." [GOC:pde, GOC:vw, ISBN:0198506732] synonym: "ornithine cycle" EXACT [] synonym: "urea biosynthesis" EXACT [] synonym: "urea biosynthetic process" EXACT [] xref: Wikipedia:Urea_cycle is_a: GO:0019627 ! urea metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0000051 name: obsolete urea cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "urea cycle intermediate metabolic process" EXACT [] synonym: "urea cycle intermediate metabolism" EXACT [] is_obsolete: true [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732] synonym: "argininosuccinate metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0000054 name: ribosomal subunit export from nucleus namespace: biological_process def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] subset: goslim_yeast synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] is_a: GO:0033750 ! ribosome localization is_a: GO:0051656 ! establishment of organelle localization is_a: GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "50S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "60S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal large subunit export from cell nucleus" EXACT [] synonym: "ribosomal large subunit export out of nucleus" EXACT [] synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal large subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "30S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "40S ribosomal subunit export from nucleus" NARROW [GOC:mah] synonym: "ribosomal small subunit export from cell nucleus" EXACT [] synonym: "ribosomal small subunit export out of nucleus" EXACT [] synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal small subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000059 name: obsolete protein import into nucleus, docking namespace: biological_process def: "OBSOLETE. A protein complex assembly process that contributes to protein import into the nucleus, and that results in the association of a cargo protein, a carrier protein such as an importin alpha/beta heterodimer, and a nucleoporin located at the periphery of the nuclear pore complex." [GOC:isa_complete, GOC:mah, PMID:14570049, PMID:7878057, PMID:9126736] comment: This term was made obsolete because the transient assembly is better captured as a protein-protein association, if at all. synonym: "protein docking during protein import into nucleus" EXACT [] synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein docking during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] synonym: "protein-nucleus import, docking" EXACT [] is_obsolete: true [Term] id: GO:0000060 name: obsolete protein import into nucleus, translocation namespace: biological_process def: "OBSOLETE. A protein transport process that contributes to protein import into the nucleus, and that results in the vectorial transfer of a cargo-carrier protein complex through the nuclear pore complex from the cytoplasmic side to the nucleoplasmic side of the nuclear envelope." [GOC:curators, ISBN:0198506732, PMID:14570049, PMID:9126736] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "protein import into cell nucleus, translocation" EXACT [] synonym: "protein translocation during protein import into nucleus" EXACT [] synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein translocation during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] synonym: "protein-nucleus import, translocation" EXACT [] is_obsolete: true [Term] id: GO:0000061 name: obsolete protein import into nucleus, substrate release namespace: biological_process def: "OBSOLETE. A protein complex disassembly process that contributes to protein import into the nucleus, and that results in the dissociation of the cargo protein and the carrier (such as an importin alpha/beta heterodimer) from each other and from the nuclear pore complex." [GOC:mah, PMID:14570049, PMID:9126736, PMID:9687515] comment: This term has been obsoleted because it represents a substep of the parent (GO:0006606 protein import into nucleus), has been incorrectly used. synonym: "protein import into cell nucleus, substrate release" EXACT [] synonym: "protein substrate release during protein import into nucleus" EXACT [] synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein substrate release during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] synonym: "protein-nucleus import, substrate release" EXACT [] is_obsolete: true [Term] id: GO:0000062 name: fatty-acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732] synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding is_a: GO:1901567 ! fatty acid derivative binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0000064 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: reactome:R-HSA-70634 "ornithine (cytosolic) + citrulline (mitochondrial) => ornithine (mitochondrial) + citrulline (cytosolic)" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0000067 name: obsolete DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. synonym: "DNA replication and chromosome cycle" EXACT [] is_obsolete: true consider: GO:0006260 consider: GO:0007059 consider: GO:0051276 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process in which replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai, GOC:jl] subset: goslim_pombe synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0000072 name: obsolete M phase specific microtubule process namespace: biological_process def: "OBSOLETE. A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] comment: This term was made obsolete because terms already exist for centrosome/spindle organization which would be more suitable for the existing annotations, and the phase could be captured as an annotation extension if necessary. synonym: "M phase specific microtubule process" EXACT [] synonym: "M-phase specific microtubule process" EXACT [] is_obsolete: true consider: GO:0007017 [Term] id: GO:0000073 name: mitotic spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "The release of duplicated mitotic spindle pole bodies (SPBs) that begins with the nucleation of microtubules from each SPB within the nucleus, leading to V-shaped spindle microtubules. Interpolar microtubules elongate from each pole forming overlapping microtubules. Capture and antiparallel sliding apart promotes initial SPB separation. Following liberation (severing of the half-bridge), SPBs diffuse through the nuclear membrane until they are opposite each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators, GOC:vw] is_a: GO:0110100 ! spindle pole body separation relationship: part_of GO:1905047 ! mitotic spindle pole body organization [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process alt_id: GO:0031576 alt_id: GO:0071779 def: "A cell cycle process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction." [GOC:mtg_cell_cycle] comment: This term should not be used in direct manual annotation as it should always be possible to minimally designate mitotic or meiotic checkpoint, and usually to additionally specify the checkpoint (i.e mitotic spindle assembly checkpoint, mitotic DNA damage checkpoint etc). Note also that the effector processes are not part of the checkpoint but are positively regulated by the checkpoint signaling and should not be annotated here. subset: gocheck_do_not_manually_annotate synonym: "G1/S checkpoint" NARROW [] synonym: "G1/S transition checkpoint" NARROW [] synonym: "G2/M checkpoint" NARROW [] synonym: "G2/M transition checkpoint" NARROW [] xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0009987 ! cellular process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A cell cycle checkpoint that prevents the initiation of nuclear division until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:curators, GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that regulates progression through the cell cycle in response to DNA damage. A DNA damage checkpoint may blocks cell cycle progression (in G1, G2 or metaphase) or slow the rate at which S phase proceeds." [GOC:mtg_cell_cycle] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0031570 ! DNA integrity checkpoint [Term] id: GO:0000078 name: obsolete cytokinesis after mitosis checkpoint namespace: biological_process def: "OBSOLETE. A mitotic cell cycle checkpoint that detects whether chromosome segregation is complete and negatively regulates cytokinesis following mitosis." [GOC:mtg_cell_cycle] comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. synonym: "cell morphogenesis checkpoint" EXACT [GOC:dph, GOC:vw] synonym: "cell shape checkpoint" EXACT [] is_obsolete: true consider: GO:0044878 consider: GO:0044879 [Term] id: GO:0000079 name: regulation of cyclin-dependent protein serine/threonine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity." [GOC:go_curators, GOC:pr] synonym: "regulation of CDK activity" EXACT [] synonym: "regulation of cyclin-dependent protein kinase activity" BROAD [] is_a: GO:0071900 ! regulation of protein serine/threonine kinase activity is_a: GO:1904029 ! regulation of cyclin-dependent protein kinase activity [Term] id: GO:0000080 name: mitotic G1 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA segregation by mitosis and the beginning of DNA synthesis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G1 phase of mitotic cell cycle" EXACT [] is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated." [GOC:mtg_cell_cycle] is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044843 ! cell cycle G1/S phase transition [Term] id: GO:0000083 name: regulation of transcription involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are involved in the transition between G1 and S phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: mitotic S phase namespace: biological_process def: "The cell cycle phase, following G1, during which DNA synthesis takes place as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "S phase of mitotic cell cycle" EXACT [] synonym: "S-phase of mitotic cell cycle" EXACT [] is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000085 name: mitotic G2 phase namespace: biological_process def: "The cell cycle 'gap' phase which is the interval between the completion of DNA synthesis and the beginning of DNA segregation by mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "G2 phase of mitotic cell cycle" EXACT [] is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! mitotic interphase [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "The mitotic cell cycle transition by which a cell in G2 commits to M phase. The process begins when the kinase activity of M cyclin/CDK complex reaches a threshold high enough for the cell cycle to proceed. This is accomplished by activating a positive feedback loop that results in the accumulation of unphosphorylated and active M cyclin/CDK complex." [GOC:mtg_cell_cycle] synonym: "mitotic G2/M transition" EXACT [] is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044839 ! cell cycle G2/M phase transition [Term] id: GO:0000087 name: mitotic M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase and occurs as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M phase of mitotic cell cycle" EXACT [] synonym: "M-phase of mitotic cell cycle" EXACT [] is_a: GO:0000279 ! M phase is_a: GO:0098763 ! mitotic cell cycle phase [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "The cell cycle phase which is the first stage of M phase of mitosis and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "The cell cycle phase, following prophase, during which chromosomes become aligned on the equatorial plate of the cell as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of a mitotic cell cycle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "The cell cycle phase during which the kinetochore microtubules shorten as chromosomes move toward the spindle poles as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "The cell cycle phase during which the polar microtubules elongate and the two poles of the spindle move farther apart as part of mitosis." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "The cell cycle phase which follows anaphase during M phase of mitosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase relationship: part_of GO:0000087 ! mitotic M phase [Term] id: GO:0000094 name: obsolete septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. synonym: "septin assembly and septum formation" EXACT [] is_obsolete: true consider: GO:0000917 consider: GO:0000918 consider: GO:0000921 [Term] id: GO:0000095 name: S-adenosyl-L-methionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015177 def: "Enables the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transmembrane transporter activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] synonym: "SAM transmembrane transporter activity" EXACT [] xref: reactome:R-HSA-8855062 "SLC25A26 exchanges cytosolic AdoMet for mitochondrial AdoHcy" is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] synonym: "sulfur amino acid breakdown" EXACT [] synonym: "sulfur amino acid catabolism" EXACT [] synonym: "sulfur amino acid degradation" EXACT [] synonym: "sulphur amino acid catabolic process" EXACT [] synonym: "sulphur amino acid catabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000100 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015178 def: "Enables the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000102 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015191 ! L-methionine transmembrane transporter activity is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process alt_id: GO:0019378 def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] synonym: "sulphate assimilation" EXACT [] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd] synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: RHEA:16357 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H(+)." [MetaCyc:GLUTAMIDOTRANS-RXN] synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2 xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: obsolete repairosome namespace: cellular_component def: "OBSOLETE. A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] comment: This term was made obsolete because 'repairosome' has fallen out of use in the literature, and the large complex described in the definition has not been confirmed to exist. The term has also confused annotators. synonym: "repairosome" EXACT [] is_obsolete: true replaced_by: GO:0000109 [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir synonym: "UvrB-UvrC complex" NARROW [PMID:12145219] synonym: "UvrBC complex" NARROW [GOC:bhm, PMID:12145219] is_a: GO:0044428 ! nuclear part is_a: GO:1990391 ! DNA repair complex [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, Tfb4p and Tfb5p. Note that Ssl2p is also called Rad25p)." [GOC:ew, PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: obsolete regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] synonym: "regulation of transcription involved in G1 phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0000083 [Term] id: GO:0000115 name: obsolete regulation of transcription involved in S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in S phase of mitotic cell cycle" EXACT [] synonym: "regulation of transcription involved in S-phase of mitotic cell cycle" EXACT [] synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0000116 name: obsolete regulation of transcription involved in G2-phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it is unclear exactly what it means. It could mean either 'regulation of transcription during phase X' or 'regulation of transition between phase X and phase Y'. synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] synonym: "regulation of transcription involved in G2-phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0000117 [Term] id: GO:0000117 name: regulation of transcription involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M transition of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G2/M transition of mitotic cell cycle" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0044452 ! nucleolar part is_a: GO:0044798 ! nuclear transcription factor complex [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol-1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN xref: RHEA:11476 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0000122 name: negative regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0010553 alt_id: GO:0045816 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "down regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of global transcription from RNA polymerase II promoter" RELATED [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of global transcription from RNA polymerase II promoter" RELATED [] synonym: "inhibition of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "negative regulation of global transcription from Pol II promoter" RELATED [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045892 ! negative regulation of transcription, DNA-templated relationship: negatively_regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] is_a: GO:0031248 ! protein acetyltransferase complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery; the ubiquitin specifc protease Ubp-8." [PMID:10637607, PMID:17337012, PMID:19056896, PMID:20838651] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex is_a: GO:1905368 ! peptidase complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "PCAF histone acetylase-associated complex" EXACT [] synonym: "SPT3-TAF9-PCAF acetylase complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A heterotrimeric transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species. It also functions as a boundary element to partition genome content into distinct domains outside Pol III promoter regions." [GOC:mah, GOC:vw, PMID:11433012, PMID:16751097] is_a: GO:0090576 ! RNA polymerase III transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The reversible, non-sexual aggregation of single-celled organisms in suspension to form aggregates of many cells known as flocs." [GOC:jl, GOC:vw, PMID:21114594, PMID:8740415] comment: The word floc derives from the Latin word floccus, which means a tuft of wool. subset: goslim_pir xref: Wikipedia:Flocculation is_a: GO:0098630 ! aggregation of unicellular organisms [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0044424 ! intracellular part [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "mitotic spindle orientation" EXACT [] synonym: "orienting of mitotic spindle" EXACT [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-(1->6)-mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735, PMID:18083825] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0000137 ! Golgi cis cisterna relationship: part_of GO:0030173 ! integral component of Golgi membrane [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] synonym: "late Golgi" RELATED [GOC:mah] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0098588 ! bounding membrane of organelle [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol-3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H(+)." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: reactome:R-HSA-75883 "O-hexadecylglycerone phosphate + NADPH + H+ => 1-hexadecyl glycerol-3-phosphate + NADP+" xref: RHEA:17341 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] synonym: "neck ring" EXACT [] is_a: GO:0110085 ! mitotic actomyosin contractile ring relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis in the bud neck of a budding cell; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [GOC:cilia, PMID:15292201, PMID:27243008, PMID:9700152] synonym: "exocyst complex" EXACT [] synonym: "Sec6/8 complex" EXACT [] xref: Wikipedia:Exocyst is_a: GO:0044448 ! cell cortex part is_a: GO:0099023 ! tethering complex [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: reactome:R-HSA-2316352 "SLC2A4 (GLUT4) vesicle translocates and docks at the plasma membrane" xref: reactome:R-HSA-432237 "Translocation of Aquaporin-2 from intracellular vesicles to the apical plasma membrane" xref: reactome:R-HSA-9023171 "Insulin secretory granule translocates across the cortical actin network" is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization is_a: GO:0044396 ! actin cortical patch organization [Term] id: GO:0000148 name: 1,3-beta-D-glucan synthase complex namespace: cellular_component def: "A protein complex that catalyzes the transfer of a glucose group from UDP-glucose to a (1->3)-beta-D-glucan chain." [EC:2.4.1.34] synonym: "(1->3)-beta-glucan synthase complex" EXACT [GOC:tb] synonym: "1,3-beta-glucan synthase complex" EXACT [GOC:tb] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1990234 ! transferase complex [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] subset: goslim_chembl synonym: "SNAP receptor binding" EXACT [] xref: reactome:R-HSA-210426 "Glutamate synaptic vesicle docking and priming" xref: reactome:R-HSA-210430 "release of L-Glutamate at the synapse" xref: reactome:R-HSA-265166 "Exocytosis of Insulin" xref: reactome:R-HSA-372505 "Acetylcholine synaptic vesicle docking and priming" xref: reactome:R-HSA-372529 "Release of acetylcholine at the synapse" xref: reactome:R-HSA-374899 "Release of noradrenaline at the synapse" xref: reactome:R-HSA-374922 "Noradrenalin synaptic vesicle docking and priming" xref: reactome:R-HSA-376357 "Vamp7 associated Lysosome to Plasma membrane transport" xref: reactome:R-HSA-376364 "Vamp8 associated secretory vesicle to plasma membrane transport" xref: reactome:R-HSA-376369 "Vamp2 associated secretory vesicle to plasma membrane transport" xref: reactome:R-HSA-380574 "Dopamine synaptic vesicle docking and priming" xref: reactome:R-HSA-380869 "Release of docked dopamine loaded synaptic vesicle" xref: reactome:R-HSA-380901 "Release of docked serotonin loaded synaptic vesicle" xref: reactome:R-HSA-380905 "Serotonin loaded synaptic vesicle docking and priming" xref: reactome:R-HSA-888589 "Release of GABA at the synapse" xref: reactome:R-HSA-9023173 "Insulin secretory granule docks at the plasma membrane" xref: reactome:R-HSA-917744 "GABA loaded synaptic vesicle Docking and Priming" is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: goslim_metagenomics synonym: "strand transferase" NARROW [] xref: reactome:R-HSA-912458 "Formation of meiotic heteroduplex" is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase and enables ubiquitin protein ligase activity. The complex also contains other proteins that may confer substrate specificity on the complex." [GOC:jh2, PMID:9529603] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000154 name: rRNA modification namespace: biological_process alt_id: GO:0016548 def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "rRNA editing" NARROW [GOC:hjd] is_a: GO:0006364 ! rRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0000155 name: phosphorelay sensor kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a histidine residue in response to detection of an extracellular signal such as a chemical ligand or change in environment, to initiate a change in cell state or activity. The two-component sensor is a histidine kinase that autophosphorylates a histidine residue in its active site. The phosphate is then transferred to an aspartate residue in a downstream response regulator, to trigger a response." [GOC:bf, GOC:mcc, PMID:10966457, PMID:20223701, PMID:9191038] synonym: "two-component sensor activity" NARROW [] synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity" NARROW [] xref: EC:2.7.3 is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0000156 name: phosphorelay response regulator activity namespace: molecular_function def: "Responds to a phosphorelay sensor to initiate a change in cell state or activity. The activity of the response regulator is regulated by transfer of a phosphate from a histidine residue in the sensor, to an aspartate residue in the response regulator. Many but not all response regulators act as transcriptional regulators to elicit a response." [GOC:bf, PMID:10966457, PMID:11842140] comment: Added is_a molecular transducer activity see https://github.com/geneontology/go-ontology/issues/15611 synonym: "two-component response regulator activity" NARROW [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] synonym: "protein phosphatase 2 complex" RELATED [GOC:dph, GOC:rl] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000160 name: phosphorelay signal transduction system namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: goslim_metagenomics synonym: "histidyl-aspartyl phosphorelay" EXACT [] synonym: "phosphorelay signal transduction system" NARROW [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0000161 name: osmosensory signaling MAPK cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals, containing at least a Hog1/Sty1 family MAPK, a Pbs2/Wis1 family MAPKK and a Ssk2/Win1 family MAP3K." [PMID:17604854, PMID:9561267] synonym: "High Osmolarity Glycerol (HOG) MAPK pathway" NARROW [PMID:20880736] synonym: "Hog1 MAPK pathway" NARROW [PMID:20880736] synonym: "Hog1/Sty1 stress-activated MAPK cascade" NARROW [] synonym: "MAPK cascade involved in osmosensory signaling pathway" EXACT [] synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] synonym: "MAPKKK cascade involved in osmosensory signaling pathway" EXACT [GOC:signaling] synonym: "MAPKKK cascade involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] is_a: GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process alt_id: GO:0009096 def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309, MetaCyc:TRPSYN-PWY] synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] synonym: "tryptophan anabolism" EXACT [] synonym: "tryptophan biosynthesis" EXACT [] synonym: "tryptophan formation" EXACT [] synonym: "tryptophan synthesis" EXACT [] xref: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000165 name: MAPK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tiers: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinase in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:mtg_signaling_feb11, PMID:20811974, PMID:9561267] comment: MAPK cascades lie downstream of many cell surface receptors and cooperate in transmitting various extracellular signals to the nucleus. One way by which the specificity of each cascade is regulated is through the existence of several distinct components in each tier of the different cascades. The cascades are typically named according to the component in the MAPK tier. synonym: "ERK/MAPK cascade" NARROW [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK signal transduction" EXACT [GOC:signaling] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade" EXACT [GOC:curators] synonym: "MAPKKK cascade during sporulation" NARROW [] synonym: "mitogen-activated protein kinase cascade" EXACT [GOC:bf] xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0023014 ! signal transduction by protein phosphorylation is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose." [GOC:mah, ISBN:0198547684] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant is_a: GO:0036094 ! small molecule binding is_a: GO:1901265 ! nucleoside phosphate binding [Term] id: GO:0000167 name: activation of MAPKKK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000168 name: activation of MAPKK activity involved in osmosensory signaling pathway namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "activation of Pbs2 kinase" NARROW [] synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000169 name: activation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] synonym: "activation of MAPK activity during osmolarity sensing" EXACT [] synonym: "activation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: reactome:R-HSA-428260 "dihydroceramide + NADPH + H+ + O2 => phytoceramide + NADP+ + H2O" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA-mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] synonym: "RNase MRP" EXACT [] xref: Wikipedia:RNase_MRP is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0000173 name: inactivation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT [] synonym: "inactivation of MAPK activity involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000174 name: obsolete inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13 xref: reactome:R-HSA-430028 "Exosome Complex hydrolyzes mRNA by 3' to 5' exoribonuclease digestion" xref: reactome:R-HSA-6791218 "12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA" xref: reactome:R-HSA-6791222 "21S pre-rRNA is nucleolytically processed at site E (site2a) to yield 18SE pre-rRNA" xref: reactome:R-HSA-6791227 "47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime processive and distributive hydrolytic exoribonuclease activity and endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] synonym: "nuclear exosome (ribonuclease complex)" EXACT [] synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime processive hydrolytic exoribonuclease activity producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "A ribonuclease complex that has 3-prime to 5-prime exoribonuclease activity and possibly endoribonuclease activity, producing 5-prime-phosphomonoesters. Participates in a multitude of cellular RNA processing and degradation events preventing nuclear export and/or translation of aberrant RNAs. Restricted to processing linear and circular single-stranded RNAs (ssRNA) only. RNAs with complex secondary structures may have to be unwound or pre-processed by co-factors prior to entering the complex, esp if the 3-prime end is structured." [PMID:17174896, PMID:20531386, PMID:26726035] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir synonym: "exosome (ribonucleasease complex)" EXACT [] synonym: "exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0044424 ! intracellular part is_a: GO:1905354 ! exoribonuclease complex [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function alt_id: GO:0043790 def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337, PMID:10690410] synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532] xref: reactome:R-HSA-6790994 "DIMT1 dimethylates adenosine-1850,1851 of 18S rRNA yielding 6-dimethyladenosine-1850,1851" xref: reactome:R-HSA-6793066 "TFB1M dimethylates adenosine-936 and adenosine-937 of 12S rRNA yielding 6-dimethyladenosine-936 and 6-dimethyladenosine-937" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: obsolete cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. synonym: "cytosolic large ribosomal subunit" EXACT [] is_obsolete: true consider: GO:0022625 [Term] id: GO:0000181 name: obsolete cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. synonym: "cytosolic small ribosomal subunit" EXACT [] is_obsolete: true consider: GO:0022627 [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] synonym: "rDNA chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase (MAPKKK)." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase" EXACT [] synonym: "activation of MAP3K activity" EXACT [GOC:bf] synonym: "activation of MAPKKK activity during sporulation" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] synonym: "positive regulation of MAPKKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase (MAPKK)." [PMID:9561267] synonym: "activation of MAP kinase kinase activity" EXACT [] synonym: "activation of MAP/ERK kinase kinase" EXACT [] synonym: "activation of MAP2K activity" EXACT [GOC:bf] synonym: "activation of MAPKK activity during sporulation" NARROW [] synonym: "positive regulation of MAPKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase (MAPK)." [PMID:9561267] synonym: "activation of MAP kinase" EXACT [] synonym: "activation of MAPK activity during sporulation" NARROW [] synonym: "MAPK activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043406 ! positive regulation of MAP kinase activity [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] synonym: "inactivation of MAPK during sporulation" NARROW [] synonym: "termination of MAPK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity [Term] id: GO:0000189 name: obsolete MAPK import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "nuclear translocation of MAPK" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000190 name: obsolete MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000191 name: obsolete activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000192 name: obsolete activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000193 name: obsolete activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000194 name: obsolete inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000195 name: obsolete nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (pseudohyphal growth)" EXACT [] is_obsolete: true [Term] id: GO:0000196 name: cell wall integrity MAPK cascade namespace: biological_process def: "A MAPK cascade that contributes to cell wall organization or biogenesis." [PMID:17604854, PMID:9561267] synonym: "cell integrity MAPK pathway" EXACT [GOC:vw, PMID:23934882] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] synonym: "MAPK cascade involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAPK cascade involved in cell wall organization or biogenesis" EXACT [] synonym: "MAPKKK cascade involved in cell wall biogenesis" EXACT [GOC:signaling] synonym: "Mpk1 cascade" NARROW [PMID:10523653] synonym: "Pmk1 MAPK cell integrity signaling" NARROW [PMID:20032302] synonym: "Pmk1 mitogen-activated protein kinase (MAPK) cell integrity pathway" NARROW [PMID:23934882] synonym: "PMK1-MAPK signal transduction pathway" NARROW [PMID:23454094] synonym: "Slt2 cascade" NARROW [PMID:10523653] is_a: GO:0051403 ! stress-activated MAPK cascade relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKKK activity involved in cell wall biogenesis" RELATED [] synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKK activity involved in cell wall biogenesis" RELATED [] synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000199 name: activation of MAPK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAPK activity involved in cell wall biogenesis" NARROW [] synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity involved in cell wall organization or biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall organization or biogenesis." [PMID:9561267] synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "inactivation of MAPK activity involved in cell wall organization or biogenesis" RELATED [] synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0000201 name: obsolete MAPK import into nucleus involved in cell wall organization or biogenesis namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall organization or biogenesis." [PMID:9561267] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "cell wall biogenesis, MAPK import into nucleus" EXACT [GOC:mah] synonym: "cell wall biogenesis, nuclear translocation of MAPK" NARROW [GOC:mah] synonym: "MAPK import into nucleus involved in cell wall biogenesis" NARROW [GOC:vw] synonym: "MAPK import into nucleus involved in cell wall integrity" EXACT [GOC:dgf, GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall biogenesis" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in cell wall integrity" NARROW [GOC:dgf, GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000202 name: obsolete MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000203 name: obsolete activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000204 name: obsolete activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000205 name: obsolete activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000206 name: obsolete inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000207 name: obsolete nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK during sporulation (sensu Saccharomyces)" EXACT [] is_obsolete: true [Term] id: GO:0000208 name: obsolete MAPK import into nucleus involved in osmosensory signaling pathway namespace: biological_process def: "OBSOLETE. The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "MAPK import into nucleus during osmolarity sensing" EXACT [GOC:mah] synonym: "MAPK import into nucleus involved in osmosensory signalling pathway" EXACT [GOC:mah] synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] synonym: "nuclear translocation of MAPK involved in osmosensory signaling pathway" NARROW [GOC:mah] synonym: "nuclear translocation of MAPK involved in osmosensory signalling pathway" NARROW [GOC:mah] synonym: "osmolarity sensing, MAPK import into nucleus" EXACT [GOC:mah] synonym: "osmolarity sensing, nuclear translocation of MAPK" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: MetaCyc:NADPYROPHOSPHAT-RXN xref: RHEA:11800 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: obsolete protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. synonym: "protein degradation tagging activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0019941 [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process alt_id: GO:0043147 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:go_curators, GOC:mah] synonym: "meiotic spindle organisation" EXACT [GOC:curators] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "meiotic spindle stabilization" RELATED [] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:1903046 ! meiotic cell cycle process [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-intron endoribonuclease activity" EXACT [] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "SEN complex" EXACT [GOC:se, PMID:22391451] synonym: "tRNA splicing endonuclease complex" EXACT [GOC:se, PMID:22391451] is_a: GO:0044428 ! nuclear part is_a: GO:1902555 ! endoribonuclease complex [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function alt_id: GO:0008665 def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O. This reaction is the transfer of the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] subset: goslim_chembl synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phosphotransferase activity" BROAD [] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0000216 name: obsolete M/G1 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah, GOC:mtg_cell_cycle] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "M/G1 transition of mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000219 name: obsolete vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" EXACT [] is_obsolete: true consider: GO:0016469 [Term] id: GO:0000220 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044437 ! vacuolar part [Term] id: GO:0000221 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000223 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-N-(N-acetyl-D-glucosaminyl)-protein + H2O = N-acetyl-beta-D-glucosaminylamine + peptide L-aspartate. This reaction is the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN xref: reactome:R-HSA-8850594 "Deglycosylation complex hydrolyses N-glycans from unfolded glycoproteins" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. This reaction is the second step of the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: MetaCyc:3.1.1.69-RXN xref: reactome:R-HSA-162857 "N-acetylglucosaminyl-PI + H2O -> glucosaminyl-PI + acetate" xref: RHEA:11660 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_pombe synonym: "microtubule cytoskeleton organisation" EXACT [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome that encodes the nuclear genome and is found in the nucleus of a eukaryotic cell during the cell cycle phases when the nucleus is intact." [GOC:dph, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000230 name: obsolete nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "nuclear mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000794 [Term] id: GO:0000231 name: obsolete cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "cytoplasmic mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000793 [Term] id: GO:0000232 name: obsolete nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "nuclear interphase chromosome" EXACT [] is_obsolete: true consider: GO:0000228 [Term] id: GO:0000233 name: obsolete cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "cytoplasmic interphase chromosome" EXACT [] is_obsolete: true consider: GO:0000229 [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: KEGG:R02037 xref: MetaCyc:2.1.1.103-RXN xref: RHEA:20365 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "The cell cycle phase in higher eukaryotes which follows mitotic prophase and during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0098763 ! mitotic cell cycle phase [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "The cell cycle phase which is the first stage of prophase I in meiosis, and during which the chromosomes first become visible." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "The cell cycle phase which follows leptotene during prophase I of meiosis, and during which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "The cell cycle phase which follows zygotene during prophase I of meiosis, and during which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "The cell cycle phase which follows pachytene during prophase I of meiosis, during which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "The cell cycle phase which follows diplotene during prophase I of meiosis, the separation of homologous chromosomes is complete and crossing over has occurred." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0098764 ! meiosis I cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex [Term] id: GO:0000244 name: spliceosomal tri-snRNP complex assembly namespace: biological_process alt_id: GO:0000351 alt_id: GO:0000355 def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] synonym: "assembly of spliceosomal tri-snRNP" EXACT [] synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] synonym: "snRNP recycling" BROAD [] synonym: "spliceosomal tri-snRNP assembly" EXACT [] synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] is_a: GO:0000387 ! spliceosomal snRNP assembly [Term] id: GO:0000245 name: spliceosomal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a spliceosomal complex, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] synonym: "spliceosome assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP(+) = ergosta-5,7,22,24(24(1))-tetraen-3beta-ol + H(+) + NADPH." [EC:1.3.1.71, RHEA:18501] synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: KEGG:R05641 xref: MetaCyc:1.3.1.71-RXN xref: RHEA:18501 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: reactome:R-HSA-195664 "Cholesta-7,24-dien-3beta-ol is desaturated to form cholesta-5,7,24-trien-3beta-ol" xref: reactome:R-HSA-6807053 "SC5D desaturates LTHSOL to 7-dehydroCHOL" is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7, RHEA:14621] synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: KEGG:R03199 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: reactome:R-HSA-191366 "Squalene 2,3-epoxide cyclizes, forming lanosterol" xref: RHEA:14621 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1 xref: reactome:R-HSA-194642 "4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form 4-methylcholesta-8(9),24-dien-3-one" xref: reactome:R-HSA-194718 "4-carboxycholesta-8(9),24-dien-3beta-ol is decarboxylated and oxidized to form cholesta-8(9),24-dien-3-one (zymosterone)" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function alt_id: GO:0050576 def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H(+)." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3-keto-steroid reductase activity" EXACT [] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: MetaCyc:1.1.1.270-RXN xref: MetaCyc:RXN3O-4110 xref: MetaCyc:RXN66-19 xref: MetaCyc:RXN66-24 xref: MetaCyc:RXN66-314 xref: MetaCyc:RXN66-319 xref: reactome:R-HSA-194632 "Zymosterone (cholesta-8(9),24-dien-3-one) is reduced to zymosterol (cholesta-8(9),24-dien-3beta-ol)" xref: reactome:R-HSA-194689 "4-methylcholesta-8(9),24-dien-3-one is reduced to 4-methylcholesta-8(9),24-dien-3beta-ol" xref: RHEA:18409 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H(+) + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.13.72 xref: MetaCyc:1.14.13.72-RXN xref: reactome:R-HSA-194641 "4,4-dimethylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-methyl,4-carboxycholesta-8(9),24-dien-3beta-ol" xref: reactome:R-HSA-194669 "4-methylcholesta-8(9),24-dien-3beta-ol is oxidized to 4-carboxycholesta-8(9),24-dien-3beta-ol" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] synonym: "allantoin metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: KEGG:R00540 xref: MetaCyc:3.5.5.1-RXN xref: RHEA:21724 xref: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: obsolete isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "isoleucine/valine:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0005304 consider: GO:0015188 [Term] id: GO:0000259 name: obsolete intracellular nucleoside transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. synonym: "intracellular nucleoside transmembrane transporter activity" EXACT [] is_obsolete: true consider: GO:0005337 consider: GO:0005622 [Term] id: GO:0000260 name: obsolete hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H(+)(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. synonym: "hydrogen-translocating V-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0000261 name: obsolete sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. synonym: "sodium-translocating V-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046962 [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: obsolete heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, alpha-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000264 name: obsolete heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, beta-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000265 name: obsolete heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "heterotrimeric G-protein GTPase, gamma-subunit" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048285 ! organelle fission [Term] id: GO:0000267 name: obsolete cell fraction namespace: cellular_component def: "OBSOLETE: A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "cell fraction" EXACT [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transmembrane transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein metabolic process" EXACT [] synonym: "murein metabolism" EXACT [] synonym: "peptidoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process alt_id: GO:0044244 def: "The chemical reactions and pathways resulting in the breakdown of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:go_curators] synonym: "multicellular organismal polysaccharide catabolic process" NARROW [] synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] synonym: "mitochondrial proton-transporting ATP synthase, peripheral stalk" EXACT [] is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process alt_id: GO:0007067 def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "mitosis" RELATED [] xref: Wikipedia:Mitosis is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle phase during which nuclear division occurs, and which is comprises the phases: prophase, metaphase, anaphase and telophase." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "The division of a cell nucleus into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: mitotic cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] subset: goslim_pombe synonym: "cytokinesis after mitosis" EXACT [] is_a: GO:0061640 ! cytoskeleton-dependent cytokinesis is_a: GO:1903047 ! mitotic cell cycle process [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). synonym: "bud site selection/establishment of cell polarity" BROAD [] is_a: GO:0030010 ! establishment of cell polarity is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis [Term] id: GO:0000284 name: obsolete shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. synonym: "shmoo orientation" EXACT [] is_obsolete: true replaced_by: GO:0000753 [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ATP = a 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.150, RHEA:13609] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: KEGG:R05802 xref: MetaCyc:2.7.1.150-RXN xref: reactome:R-HSA-1675910 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the late endosome membrane" xref: reactome:R-HSA-1675921 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the Golgi membrane" xref: reactome:R-HSA-1676134 "PI3P is phosphorylated to PI(3,5)P2 by PIP5K1A/B at the plasma membrane" xref: reactome:R-HSA-1676168 "PI3P is phosphorylated to PI(3,5)P2 by PIKFYVE at the early endosome membrane" xref: RHEA:13609 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H(+)." [EC:1.4.1.1] synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN xref: RHEA:18405 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] synonym: "magnesium binding" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] synonym: "deadenylation-dependent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000289 name: nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] synonym: "3' to 5' mRNA deadenylation" RELATED [] synonym: "mRNA deadenylation" RELATED [] synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000290 name: deadenylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] synonym: "deadenylylation-dependent decapping" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000292 name: RNA fragment catabolic process namespace: biological_process alt_id: GO:0030452 def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] synonym: "group I intron catabolic process" NARROW [] synonym: "RNA fragment breakdown" EXACT [] synonym: "RNA fragment catabolism" EXACT [GOC:mah] synonym: "RNA fragment degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H(+)." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN xref: RHEA:15061 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] synonym: "endonucleolytic mRNA decay" EXACT [] synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "mRNA catabolic process, endonucleolytic" EXACT [] synonym: "mRNA catabolism, endonucleolytic" EXACT [] synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of a membrane to the other." [PMID:11566870] xref: reactome:R-HSA-389652 "PMP34-mediated exchange of cytosolic ATP for peroxisomal AMP" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport is_a: GO:0015893 ! drug transport [Term] id: GO:0000297 name: spermine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of spermine from one side of a membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: obsolete integral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE: Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "integral to membrane of membrane fraction" EXACT [] is_obsolete: true consider: GO:0016021 [Term] id: GO:0000300 name: obsolete peripheral to membrane of membrane fraction namespace: cellular_component def: "OBSOLETE: Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "peripheral to membrane of membrane fraction" EXACT [] is_obsolete: true consider: GO:0019898 [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732] is_a: GO:0000305 ! response to oxygen radical [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0007584 ! response to nutrient is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000306 name: extrinsic component of vacuolar membrane namespace: cellular_component def: "The component of a vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] synonym: "extrinsic to vacuolar membrane" EXACT [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] is_a: GO:0044424 ! intracellular part is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: MetaCyc:2.7.7.1-RXN xref: reactome:R-HSA-8939959 "NMNAT2 transfers an adenylyl group from ATP to NMN to yield NAD+" xref: RHEA:21360 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity namespace: molecular_function alt_id: GO:0009043 def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate." [EC:2.4.2.22, GOC:clt] synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: MetaCyc:XANPRIBOSYLTRAN-RXN xref: RHEA:10800 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044435 ! plastid part relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome is_a: GO:0044422 ! organelle part [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] is_a: GO:0015935 ! small ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0015934 ! large ribosomal subunit relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphite transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0000319 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: plant-type vacuole namespace: cellular_component def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole, cell cycle-independent morphology" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000329 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000330 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, PMID:10503189] xref: Wikipedia:Contractile_vacuole is_a: GO:0005773 ! vacuole is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] is_a: GO:0000497 ! DNA template activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [GOC:BHF-UCL, PMID:11884619, PMID:1808260] synonym: "TERT-TERC complex" RELATED [GOC:nc, PMID:19701182] is_a: GO:0005697 ! telomerase holoenzyme complex is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O(2) = cis,cis-2-amino-3-(3-oxoprop-1-enyl)but-2-enedioate + H(+)." [EC:1.13.11.6, RHEA:17953] synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: KEGG:R02665 xref: MetaCyc:1.13.11.6-RXN xref: reactome:R-HSA-71218 "3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde" xref: RHEA:17953 xref: UM-BBD_reactionID:r1027 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] synonym: "down regulation of DNA transposition" EXACT [] synonym: "down-regulation of DNA transposition" EXACT [] synonym: "downregulation of DNA transposition" EXACT [] synonym: "inhibition of DNA transposition" NARROW [] synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0045910 ! negative regulation of DNA recombination relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000336 name: positive regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] synonym: "activation of DNA transposition" NARROW [] synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] synonym: "stimulation of DNA transposition" NARROW [] synonym: "up regulation of DNA transposition" EXACT [] synonym: "up-regulation of DNA transposition" EXACT [] synonym: "upregulation of DNA transposition" EXACT [] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0045911 ! positive regulation of DNA recombination relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000337 name: regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] synonym: "regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0010528 ! regulation of transposition relationship: regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process alt_id: GO:0010388 def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] synonym: "cullin deneddylation" NARROW [] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) group or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 7-methylguanosine group added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) group located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000348 name: mRNA branch site recognition namespace: biological_process alt_id: GO:0000370 alt_id: GO:0000371 def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). synonym: "nuclear mRNA branch site recognition" EXACT [GOC:vw] synonym: "spliceosomal A complex biosynthesis" NARROW [] synonym: "spliceosomal A complex formation" NARROW [] synonym: "spliceosomal B complex biosynthesis" NARROW [] synonym: "spliceosomal B complex formation" NARROW [] synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly [Term] id: GO:0000349 name: generation of catalytic spliceosome for first transesterification step namespace: biological_process alt_id: GO:0000356 alt_id: GO:0000357 def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-2 complex formation" NARROW [] synonym: "spliceosomal C1 complex biosynthesis" NARROW [] synonym: "spliceosomal C1 complex formation" NARROW [] synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000350 name: generation of catalytic spliceosome for second transesterification step namespace: biological_process alt_id: GO:0000358 alt_id: GO:0000359 def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] synonym: "formation of spliceosomal A2-2 complex" NARROW [] synonym: "formation of spliceosomal C1 complex" NARROW [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-3 complex formation" NARROW [] synonym: "spliceosomal C2 complex biosynthesis" NARROW [] synonym: "spliceosomal C2 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000352 name: trans assembly of SL-containing precatalytic spliceosome namespace: biological_process def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000353 name: formation of quadruple SL/U4/U5/U6 snRNP namespace: biological_process def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] comment: Note that this step is analogous to 5' splice site selection in cis-splicing. is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0045291 ! mRNA trans splicing, SL addition [Term] id: GO:0000354 name: cis assembly of pre-catalytic spliceosome namespace: biological_process alt_id: GO:0000360 alt_id: GO:0000361 def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] synonym: "formation of spliceosomal A2-1 complex" NARROW [] synonym: "formation of spliceosomal B1 complex" NARROW [] synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-1 complex formation" NARROW [] synonym: "spliceosomal B1 complex biosynthesis" NARROW [] synonym: "spliceosomal B1 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000362 name: obsolete first U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "first U2-type spliceosomal transesterification activity" EXACT [] synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000363 name: obsolete first U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "first U12-type spliceosomal transesterification activity" EXACT [] synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000364 name: obsolete second U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "second U2-type spliceosomal transesterification activity" EXACT [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000365 name: mRNA trans splicing, via spliceosome namespace: biological_process def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA trans splicing, via spliceosome" EXACT [GOC:vw] synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000366 name: intergenic mRNA trans splicing namespace: biological_process def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] synonym: "intergenic nuclear mRNA trans splicing" EXACT [GOC:vw] is_a: GO:0000365 ! mRNA trans splicing, via spliceosome is_a: GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000367 name: obsolete second U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "second U12-type spliceosomal transesterification activity" EXACT [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000372 name: Group I intron splicing namespace: biological_process def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). synonym: "mRNA splicing" RELATED [] is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile [Term] id: GO:0000373 name: Group II intron splicing namespace: biological_process def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000374 name: Group III intron splicing namespace: biological_process def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. synonym: "mRNA splicing" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: goslim_pir synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000376 name: RNA splicing, via transesterification reactions with guanosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000378 name: RNA exon ligation namespace: biological_process def: "The RNA metabolic process that joins two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] comment: Note that this is not a part of spliceosomal RNA splicing. is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000379 name: tRNA-type intron splice site recognition and cleavage namespace: biological_process def: "RNA processing that begins when the tertiary structure of a tRNA type intron is recognized, and ends when the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] is_a: GO:0006396 ! RNA processing relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000380 name: alternative mRNA splicing, via spliceosome namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. synonym: "alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000381 name: regulation of alternative mRNA splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] synonym: "regulation of alternative nuclear mRNA splicing, via spliceosome" EXACT [GOC:vw] synonym: "splice site selection" BROAD [] is_a: GO:0048024 ! regulation of mRNA splicing, via spliceosome relationship: regulates GO:0000380 ! alternative mRNA splicing, via spliceosome [Term] id: GO:0000384 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0000386 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0000387 name: spliceosomal snRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000388 name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) namespace: biological_process alt_id: GO:0000396 alt_id: GO:0000397 def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "spliceosomal A1 complex biosynthesis" NARROW [] synonym: "spliceosomal A1 complex formation" NARROW [] synonym: "spliceosomal B2 complex biosynthesis" NARROW [] synonym: "spliceosomal B2 complex formation" NARROW [] synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000389 name: mRNA 3'-splice site recognition namespace: biological_process alt_id: GO:0000382 alt_id: GO:0000383 def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA 3'-splice site recognition" EXACT [GOC:vw] synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection [Term] id: GO:0000390 name: spliceosomal complex disassembly namespace: biological_process alt_id: GO:0000391 alt_id: GO:0000392 def: "Disassembly of a spliceosomal complex with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "spliceosome complex disassembly" EXACT [] synonym: "spliceosome disassembly" BROAD [] synonym: "U12-type spliceosome disassembly" NARROW [] synonym: "U2-type spliceosome disassembly" NARROW [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000393 name: spliceosomal conformational changes to generate catalytic conformation namespace: biological_process def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! mRNA splicing, via spliceosome [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000395 name: mRNA 5'-splice site recognition namespace: biological_process alt_id: GO:0000368 alt_id: GO:0000369 def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). synonym: "nuclear mRNA 5' splice site recognition" EXACT [] synonym: "nuclear mRNA 5'-splice site recognition" EXACT [GOC:vw] synonym: "spliceosomal CC complex biosynthesis" NARROW [] synonym: "spliceosomal CC complex formation" NARROW [] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection relationship: part_of GO:0045292 ! mRNA cis splicing, via spliceosome [Term] id: GO:0000398 name: mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732, ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing, via spliceosome" EXACT [GOC:krc, GOC:vw] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing [Term] id: GO:0000399 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] is_a: GO:0032155 ! cell division site part relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000400 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000401 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000402 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000403 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "splayed Y-form DNA binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000404 name: heteroduplex DNA loop binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] synonym: "loop DNA binding" RELATED [GOC:jh] is_a: GO:0000217 ! DNA secondary structure binding is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0000405 name: bubble DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, GOC:vw, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000406 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000407 name: phagophore assembly site namespace: cellular_component def: "Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "PAS" EXACT [] synonym: "perivacuolar space" NARROW [] synonym: "pre-autophagosomal structure" NARROW [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000408 name: EKC/KEOPS complex namespace: cellular_component def: "A protein complex involved in t6A tRNA modification; originally proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, GOC:vw, PMID:16564010, PMID:16874308, PMID:21183954, PMID:23945934] synonym: "endopeptidase-like kinase chromatin-associated protein complex" EXACT [] synonym: "KEOPS/EKC complex" EXACT [PMID:21183954, PMID:23945934] synonym: "kinase, putative endopeptidase and other proteins of small size protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000409 name: regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] is_a: GO:0006355 ! regulation of transcription, DNA-templated [Term] id: GO:0000410 name: carbon catabolite repression of transcription by galactose namespace: biological_process def: "A transcription regulation process in which the presence of galactose that leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:mah] synonym: "down regulation of transcription by galactose" EXACT [] synonym: "down-regulation of transcription by galactose" EXACT [] synonym: "downregulation of transcription by galactose" EXACT [] synonym: "inhibition of transcription by galactose" NARROW [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000411 name: positive regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by galactose" NARROW [] synonym: "stimulation of transcription by galactose" NARROW [] synonym: "up regulation of transcription by galactose" EXACT [] synonym: "up-regulation of transcription by galactose" EXACT [] synonym: "upregulation of transcription by galactose" EXACT [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000412 name: histone peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] synonym: "histone proline isomerization" EXACT [] is_a: GO:0000413 ! protein peptidyl-prolyl isomerization is_a: GO:0016570 ! histone modification [Term] id: GO:0000413 name: protein peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] synonym: "protein proline isomerization" EXACT [] is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0000414 name: regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] is_a: GO:0031060 ! regulation of histone methylation relationship: regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000415 name: negative regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "down regulation of histone H3-K36 methylation" EXACT [] synonym: "down-regulation of histone H3-K36 methylation" EXACT [] synonym: "downregulation of histone H3-K36 methylation" EXACT [] synonym: "inhibition of histone H3-K36 methylation" NARROW [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031061 ! negative regulation of histone methylation relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000416 name: positive regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "activation of histone H3-K36 methylation" NARROW [] synonym: "stimulation of histone H3-K36 methylation" NARROW [] synonym: "up regulation of histone H3-K36 methylation" EXACT [] synonym: "up-regulation of histone H3-K36 methylation" EXACT [] synonym: "upregulation of histone H3-K36 methylation" EXACT [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031062 ! positive regulation of histone methylation relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000417 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] synonym: "HIRA complex" EXACT [PMID:19620282, PMID:20976105] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0000418 name: RNA polymerase IV complex namespace: cellular_component alt_id: GO:0000420 def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase V, while the largest subunit is found only in RNAP IV complex." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IV complex" EXACT [] synonym: "DNA-directed RNA polymerase IVa complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000419 name: RNA polymerase V complex namespace: cellular_component alt_id: GO:0080137 def: "RNA polymerase V is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Pol V is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984, PMID:19110459] synonym: "DNA-directed RNA polymerase IVb complex" EXACT [] synonym: "DNA-directed RNA polymerase V complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000421 name: autophagosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagosome, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:autophagy, GOC:isa_complete] synonym: "autophagic vacuole membrane" EXACT [GOC:autophagy] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005776 ! autophagosome [Term] id: GO:0000422 name: autophagy of mitochondrion namespace: biological_process def: "The autophagic process in which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions." [GOC:autophagy, PMID:15798367, PMID:19289147, PMID:23065344] synonym: "mitochondrion autophagy" EXACT [GOC:autophagy] synonym: "mitophagy" RELATED [] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0006914 ! autophagy is_a: GO:0061726 ! mitochondrion disassembly [Term] id: GO:0000423 name: mitophagy namespace: biological_process def: "The selective autophagy process in which a mitochondrion is degraded by macroautophagy." [PMID:15798367] comment: Note that this terms refers to the macroautophagy process and is named by common usage. Be aware that there are a separate micromitophagy and mitophagy by induced vacuole formation processes. synonym: "macromitophagy" EXACT [] is_a: GO:0000422 ! autophagy of mitochondrion is_a: GO:0061912 ! selective autophagy [Term] id: GO:0000424 name: micromitophagy namespace: biological_process def: "Degradation of a mitochondrion by lysosomal microautophagy." [PMID:15798367, PMID:27003723] comment: Note that this term is not a child of mitophagy because the community genrally uses that latter to refer to the macroautophagy of mitochondria. is_a: GO:0000422 ! autophagy of mitochondrion is_a: GO:0016237 ! lysosomal microautophagy [Term] id: GO:0000425 name: pexophagy namespace: biological_process def: "The selective autophagy process in which a peroxisome is degraded by macroautophagy." [GOC:autophagy, PMID:12914914, PMID:16973210] synonym: "macropexophagy" EXACT [] is_a: GO:0030242 ! autophagy of peroxisome is_a: GO:0061912 ! selective autophagy [Term] id: GO:0000426 name: micropexophagy namespace: biological_process def: "Degradation of a peroxisome by lysosomal microautophagy." [GOC:autophagy, GOC:pad, PMID:12914914, PMID:15350980, PMID:16973210] comment: Note that this term is not a child of pexophagy because the community usually uses the latter to refer to the macroautohagy process. is_a: GO:0016237 ! lysosomal microautophagy is_a: GO:0030242 ! autophagy of peroxisome [Term] id: GO:0000427 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044435 ! plastid part [Term] id: GO:0000428 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0000429 name: carbon catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc, GOC:mah] synonym: "regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0045990 ! carbon catabolite regulation of transcription [Term] id: GO:0000430 name: regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0000431 name: regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000432 name: positive regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter is_a: GO:0046016 ! positive regulation of transcription by glucose [Term] id: GO:0000433 name: carbon catabolite repression of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "A transcription regulation process in which the presence of glucose leads to a decrease in the frequency, rate, or extent of transcription of specific RNA polymerase II-transcribed genes involved in the metabolism of other carbon sources. Carbon catabolite repression is a mechanism of genetic regulation which the accumulation of catabolites of one substance in the cell represses the formation of enzymes that contribute to the catabolism of other substances." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] is_a: GO:0045014 ! carbon catabolite repression of transcription by glucose is_a: GO:0061987 ! negative regulation of transcription from RNA polymerase II promoter by glucose [Term] id: GO:0000434 name: carbon catabolite repression of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] is_a: GO:0000410 ! carbon catabolite repression of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000437 ! carbon catabolite repression of transcription from RNA polymerase II promoter [Term] id: GO:0000435 name: positive regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] is_a: GO:0000411 ! positive regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000436 ! carbon catabolite activation of transcription from RNA polymerase II promoter [Term] id: GO:0000436 name: carbon catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "positive regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0045991 ! carbon catabolite activation of transcription [Term] id: GO:0000437 name: carbon catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one carbon source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other carbon sources." [GOC:krc] synonym: "negative regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [GOC:mah] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0000429 ! carbon catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0045013 ! carbon catabolite repression of transcription [Term] id: GO:0000438 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component alt_id: GO:0000443 def: "The core TFIIH complex when it is part of the general transcription factor TFIIH." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "SSL2-core TFIIH complex portion of holo TFIIH complex" EXACT [] is_a: GO:0000439 ! transcription factor TFIIH core complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0005675 ! transcription factor TFIIH holo complex [Term] id: GO:0000439 name: transcription factor TFIIH core complex namespace: cellular_component alt_id: GO:0000441 def: "The 7 subunit core of TFIIH that is a part of either the general transcription factor holo-TFIIH or the nucleotide-excision repair factor 3 complex. In S. cerevisiae/humans the complex is composed of: Ssl2/XPB, Tfb1/p62, Tfb2/p52, Ssl1/p44, Tfb4/p34, Tfb5/p8 and Rad3/XPD." [GOC:ew, GOC:krc, PMID:14500720, PMID:17215295, PMID:22308316, PMID:22572993, PMID:23028141, PMID:7813015] subset: goslim_pir synonym: "core TFIIH complex" EXACT [] synonym: "SSL2-core TFIIH complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0000440 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component alt_id: GO:0000442 def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3)." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "SSL2-core TFIIH complex portion of NEF3 complex" EXACT [] is_a: GO:0000439 ! transcription factor TFIIH core complex relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex [Term] id: GO:0000444 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000445 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] is_a: GO:0000347 ! THO complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000446 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp2, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, GOC:se, PMID:11060033, PMID:11979277, PMID:16983072] is_a: GO:0000347 ! THO complex is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0000447 name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A2" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000448 name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:0000490 def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "cleavage at C2" RELATED [] synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000449 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000450 name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000451 name: rRNA 2'-O-methylation namespace: biological_process def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0000452 name: snoRNA guided rRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337] synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000453 name: enzyme-directed rRNA 2'-O-methylation namespace: biological_process def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000454 name: snoRNA guided rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000455 name: enzyme-directed rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000456 name: obsolete dimethylation involved in SSU-rRNA maturation namespace: biological_process def: "OBSOLETE. Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337] comment: The reason for obsoletion is that this term can be captured as a GO-CAM model. is_obsolete: true [Term] id: GO:0000457 name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000458 name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000459 name: exonucleolytic trimming involved in rRNA processing namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090503 ! RNA phosphodiester bond hydrolysis, exonucleolytic [Term] id: GO:0000460 name: maturation of 5.8S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000461 name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at site D" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000462 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:1990041 def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] synonym: "maturation of 18S rRNA" NARROW [] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000463 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000464 name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at A3" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000465 name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000466 name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000467 name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000468 name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] synonym: "processing at B2" NARROW [] is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000469 name: cleavage involved in rRNA processing namespace: biological_process def: "Any phosphodiester bond hydrolysis involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis relationship: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000470 name: maturation of LSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000471 name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000472 name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A1" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000473 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000474 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000475 name: maturation of 2S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000476 name: maturation of 4.5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000477 name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "processing at C1" NARROW [] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000478 name: endonucleolytic cleavage involved in rRNA processing namespace: biological_process def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0090502 ! RNA phosphodiester bond hydrolysis, endonucleolytic [Term] id: GO:0000479 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000480 name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] synonym: "endonucleolytic cleavage at A0" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000482 name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000481 ! maturation of 5S rRNA [Term] id: GO:0000483 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000484 name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000485 name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA [Term] id: GO:0000486 name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000487 name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000488 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000489 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000491 name: small nucleolar ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "snoRNP assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0000492 name: box C/D snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000493 name: box H/ACA snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000494 name: box C/D snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] synonym: "box C/D snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0000497 name: DNA template activity namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. synonym: "base pairing with DNA" RELATED [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0000500 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "RNA polymerase I upstream activation factor complex" EXACT [] synonym: "UAF" EXACT [] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "The reversible, non-sexual aggregation of cells mediated by the binding of proteins in the cell wall of one cell to carbohydrates in the cell wall of another cell. An example of this process is found in Saccharomyces cerevisiae, in which it is pH- and calcium-dependent." [GOC:mcc, GOC:sgd_curators, GOC:vw, PMID:21114594] is_a: GO:0000128 ! flocculation [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation, found in eukaryotes, archaea and some bacteria. In eukaryotes, this complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb, http://en.wikipedia.org/wiki/Proteasome] subset: goslim_pir synonym: "26S proteasome" NARROW [] synonym: "proteasome" EXACT [GOC:cjm] is_a: GO:0044424 ! intracellular part is_a: GO:1905369 ! endopeptidase complex [Term] id: GO:0000504 name: obsolete proteasome regulatory particle (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. synonym: "26S proteasome" NARROW [] synonym: "proteasome regulatory particle (sensu Bacteria)" EXACT [] is_obsolete: true [Term] id: GO:0000506 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2 is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0000702 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000703 name: oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0019004 def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "oxidized pyrimidine base lesion DNA N-glycosylase activity" EXACT [GOC:go_curators] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: reactome:R-HSA-110224 "Cleavage of thymine glycol by NTHL1 glycosylase" xref: reactome:R-HSA-110226 "Cleavage of cytosine glycol by NTHL1 glycosylase" xref: reactome:R-HSA-110227 "Cleavage of dihydrouracil by NTHL1 glycosylase" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity [Term] id: GO:0000704 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000705 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] synonym: "achiasmate meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I [Term] id: GO:0000706 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:1903046 ! meiotic cell cycle process [Term] id: GO:0000707 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000708 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] synonym: "meiotic displacement loop biosynthesis" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop formation" RELATED [GOC:mah, GOC:vw] is_a: GO:0042148 ! strand invasion is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000709 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000710 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] is_a: GO:0006298 ! mismatch repair is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000711 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000712 name: resolution of meiotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] is_a: GO:0061982 ! meiosis I cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination relationship: part_of GO:0051307 ! meiotic chromosome separation [Term] id: GO:0000713 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] is_a: GO:0061982 ! meiosis I cell cycle process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process in which the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] synonym: "meiotic D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "meiotic displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0000732 ! strand displacement is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0000715 name: nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000716 name: transcription-coupled nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] synonym: "pyrimidine-dimer repair, DNA damage recognition" RELATED [] is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0000717 name: nucleotide-excision repair, DNA duplex unwinding namespace: biological_process def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000718 name: nucleotide-excision repair, DNA damage removal namespace: biological_process def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0044349 ! DNA excision relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000719 name: photoreactive repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] synonym: "pyrimidine-dimer repair by photolyase" NARROW [] is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000720 name: pyrimidine dimer repair by nucleotide-excision repair namespace: biological_process def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. is_a: GO:0006289 ! nucleotide-excision repair is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000721 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H(+)." [EC:1.1.1.4] synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN xref: RHEA:24340 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000722 name: telomere maintenance via recombination namespace: biological_process def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] synonym: "telomerase-independent telomere maintenance" RELATED [] is_a: GO:0000723 ! telomere maintenance is_a: GO:0006312 ! mitotic recombination [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins, the length of telomeric DNA and the replication and repair of the DNA. These processes includes those that shorten, lengthen, replicate and repair the telomeric DNA sequences." [GOC:BHF, GOC:BHF_telomere, GOC:elh, GOC:rl, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] is_a: GO:0006281 ! DNA repair [Term] id: GO:0000727 name: double-strand break repair via break-induced replication namespace: biological_process def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0022414 ! reproductive process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006302 ! double-strand break repair [Term] id: GO:0000730 name: DNA recombinase assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] is_a: GO:0065004 ! protein-DNA complex assembly is_a: GO:0090735 ! DNA repair complex assembly relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0000731 name: DNA synthesis involved in DNA repair namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end and uses the homologous intact duplex as the template." [PMID:10357855] synonym: "DNA repair synthesis" BROAD [] synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] synonym: "mitotic DNA repair synthesis" NARROW [GOC:mah] is_a: GO:0071897 ! DNA biosynthetic process relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] synonym: "D-loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "D-loop processing" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop dissociation" RELATED [GOC:mah, GOC:vw] synonym: "displacement loop processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000733 name: DNA strand renaturation namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032392 ! DNA geometric change [Term] id: GO:0000734 name: gene conversion at mating-type locus, DNA repair synthesis namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000735 name: removal of nonhomologous ends namespace: biological_process def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0000736 name: double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0000735 ! removal of nonhomologous ends relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000737 name: DNA catabolic process, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] synonym: "DNA breakdown, endonucleolytic" EXACT [] synonym: "DNA degradation, endonucleolytic" EXACT [] synonym: "endonucleolytic degradation of DNA" EXACT [] synonym: "endonucleolytic DNA catabolism" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0000738 name: DNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] synonym: "DNA breakdown, exonucleolytic" EXACT [] synonym: "DNA degradation, exonucleolytic" EXACT [] synonym: "exonucleolytic degradation of DNA" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0000739 name: obsolete DNA strand annealing activity namespace: molecular_function def: "OBSOLETE. Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] comment: This term was made obsolete because it describes a process and not an activity. synonym: "DNA strand annealing activity" EXACT [] is_obsolete: true consider: GO:0000733 consider: GO:0036292 consider: GO:0036310 [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The microtubule-based movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt, GOC:vw, PMID:16380440] synonym: "nuclear congression" EXACT [GOC:vw] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0030473 ! nuclear migration along microtubule relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000744 name: karyogamy involved in conjugation with mutual genetic exchange namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from two nuclei as a result of fusing the nuclear envelopes that surround each nuclei. This takes place following the mutual exchange of one of the two nuclei produced by the mitosis that follows the second meiotic nuclear division. This occurs in ciliated protozoans such as Tetrahymena." [GOC:mah, GOC:pg] comment: Changed definition https://github.com/geneontology/go-ontology/issues/16248. synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000745 name: nuclear migration involved in conjugation with mutual genetic exchange namespace: biological_process def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Conjugation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction is_a: GO:0140253 ! cell-cell fusion [Term] id: GO:0000748 name: conjugation with mutual genetic exchange namespace: biological_process def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] synonym: "conjugation without cellular fusion" EXACT [] is_a: GO:0000746 ! conjugation [Term] id: GO:0000749 name: response to pheromone triggering conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that positively regulates the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion is_a: GO:0071444 ! cellular response to pheromone [Term] id: GO:0000750 name: pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007330 alt_id: GO:0030454 def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "transduction of mating signal" BROAD [] is_a: GO:0032005 ! signal transduction involved in positive regulation of conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000751 name: mitotic cell cycle G1 arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The cell cycle regulatory process in which the mitotic cell cycle is halted during G1 as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "cell cycle arrest in response to pheromone" BROAD [] is_a: GO:0071850 ! mitotic cell cycle arrest relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0098630 ! aggregation of unicellular organisms relationship: part_of GO:0000747 ! conjugation with cellular fusion relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation of signalling pathway by response to pheromone involved in conjugation with cellular fusion" EXACT [GOC:mah] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0000749 ! response to pheromone triggering conjugation with cellular fusion [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" RELATED [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000756 name: response to pheromone regulating conjugation with mutual genetic exchange namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus regulating the process of conjugation without cellular fusion." [GOC:clt] synonym: "response to pheromone triggering conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0046999 ! regulation of conjugation is_a: GO:0071444 ! cellular response to pheromone relationship: regulates GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000757 name: obsolete signal transduction involved in regulation of conjugation with mutual genetic exchange namespace: biological_process def: "OBSOLETE. A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] comment: This term was obsoleted because its label and definitions were not clear. It had never been used for annotation. https://github.com/geneontology/go-ontology/issues/15815 synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0000758 name: agglutination involved in conjugation with mutual genetic exchange namespace: biological_process def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] synonym: "sexual flocculation" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0098630 ! aggregation of unicellular organisms relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange relationship: part_of GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange [Term] id: GO:0000759 name: cell morphogenesis involved in conjugation with mutual genetic exchange namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000767 ! cell morphogenesis involved in conjugation relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000760 name: adaptation to pheromone regulating conjugation with mutual genetic exchange namespace: biological_process def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] is_a: GO:0000756 ! response to pheromone regulating conjugation with mutual genetic exchange is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000761 name: conjugant formation namespace: biological_process def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] is_a: GO:0000771 ! agglutination involved in conjugation relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000762 name: pheromone-induced unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] is_a: GO:0009291 ! unidirectional conjugation [Term] id: GO:0000763 name: obsolete cell morphogenesis involved in unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cell morphogenesis involved in unidirectional conjugation" EXACT [] is_obsolete: true [Term] id: GO:0000764 name: obsolete cellular morphogenesis involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "OBSOLETE. The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] comment: This term was made obsolete because unidirectional conjugation occurs only in prokaryotes, which do not undergo morphogenetic changes associated with conjugation. In short, the process described by this term does not occur. synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] synonym: "cellular morphogenesis involved in pheromone-induced unidirectional conjugation" EXACT [] is_obsolete: true [Term] id: GO:0000765 name: response to pheromone regulating pheromone-induced unidirectional conjugation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that regulates the process of pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0019236 ! response to pheromone is_a: GO:0046999 ! regulation of conjugation relationship: regulates GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000766 name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] synonym: "negative adaptation of signalling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation" EXACT [GOC:mah] is_a: GO:0022401 ! negative adaptation of signaling pathway relationship: part_of GO:0000765 ! response to pheromone regulating pheromone-induced unidirectional conjugation [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] is_a: GO:0006949 ! syncytium formation is_a: GO:0140253 ! cell-cell fusion [Term] id: GO:0000769 name: syncytium formation by mitosis without cytokinesis namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cytokinesis." [GOC:mah, GOC:tb] synonym: "syncytium formation by mitosis without cell division" RELATED [GOC:mah] is_a: GO:0006949 ! syncytium formation [Term] id: GO:0000770 name: peptide pheromone export namespace: biological_process alt_id: GO:0007325 def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] synonym: "a-factor export" NARROW [] is_a: GO:0009914 ! hormone transport is_a: GO:0015833 ! peptide transport [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0098610 ! adhesion between unicellular organisms relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000772 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0000773 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000774 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] xref: reactome:R-HSA-5252079 "HSP110s exchange ATP for ADP on HSP70s:ADP" is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component alt_id: GO:0097521 def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:cjm, GOC:elh, GOC:kmv, GOC:pr] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. synonym: "centromere" RELATED [] synonym: "centromere complex" EXACT [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] xref: SO:0000577 is_a: GO:0098687 ! chromosomal region [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] comment: Note that the kinetochore overlaps the centromeric DNA, but centromeric DNA is not part of the kinetochore. subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0032991 ! protein-containing complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0000777 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000776 ! kinetochore relationship: part_of GO:0000779 ! condensed chromosome, centromeric region [Term] id: GO:0000778 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed nuclear chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000777 ! condensed chromosome kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region [Term] id: GO:0000779 name: condensed chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centric region" EXACT [] synonym: "condensed chromosome, centromere" RELATED [] synonym: "condensed chromosome, pericentric region" RELATED [] is_a: GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000780 name: condensed nuclear chromosome, centromeric region namespace: cellular_component def: "The region of a condensed nuclear chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centric region" EXACT [] synonym: "condensed nuclear chromosome, centromere" RELATED [] synonym: "condensed nuclear chromosome, pericentric region" RELATED [] is_a: GO:0000779 ! condensed chromosome, centromeric region is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] xref: SO:0000624 is_a: GO:0098687 ! chromosomal region [Term] id: GO:0000782 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0000783 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0000782 ! telomere cap complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0000784 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear nuclear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] is_a: GO:0000781 ! chromosome, telomeric region is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome." [GOC:elh, PMID:20404130] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000786 name: nucleosome namespace: cellular_component alt_id: GO:0005718 def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: Wikipedia:Nucleosome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part is_a: GO:0044815 ! DNA packaging complex relationship: part_of GO:0000785 ! chromatin [Term] id: GO:0000787 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000789 ! cytoplasmic chromatin [Term] id: GO:0000788 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000789 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the cytoplasm." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome in the nucleus." [GOC:elh, PMID:20404130] is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct nuclear chromosome." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome [Term] id: GO:0000795 name: synaptonemal complex namespace: cellular_component alt_id: GO:0005716 def: "A proteinaceous scaffold found between homologous chromosomes during meiosis. It consists of 2 lateral elements and a central element, all running parallel to each other. Transverse filaments connect the lateral elements to the central element." [DOI:10.5772/29752, GOC:elh] xref: Wikipedia:Synaptonemal_complex is_a: GO:0099086 ! synaptonemal structure [Term] id: GO:0000796 name: condensin complex namespace: cellular_component alt_id: GO:0005676 alt_id: GO:0008620 def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "13S condensin complex" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0044427 ! chromosomal part is_a: GO:0044815 ! DNA packaging complex relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000797 name: condensin core heterodimer namespace: cellular_component alt_id: GO:0008621 def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "8S condensin complex" NARROW [] synonym: "Smc2-Smc4 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000796 ! condensin complex [Term] id: GO:0000798 name: nuclear cohesin complex namespace: cellular_component def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0008278 ! cohesin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000799 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] is_a: GO:0000796 ! condensin complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000800 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] comment: In species that have a synaptonemal complex, the lateral elements are part of this complex. S.pombe is an example of a species that lacks a (canonical) synaptonemal complex, but still has lateral elements. synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000801 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000802 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome [Term] id: GO:0000804 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000805 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0582227089, PMID:20622855] xref: Wikipedia:X_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000806 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0582227089, PMID:20622855] xref: Wikipedia:Y_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000807 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, GOC:mr, ISBN:0321000382, PMID:20622855] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000809 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000810 name: diacylglycerol diphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a 1,2-diacyl-sn-glycerol 3-diphosphate + H2O = a 1,2-diacyl-sn-glycerol 3-phosphate + phosphate." [EC:3.1.3.81, GOC:kad, MetaCyc:RXN-11277, PMID:8567632, PMID:9452443] comment: The enzyme entry for EC 3.1.3.81 states that this is a bifunctional enzyme (http://www.chem.qmul.ac.uk/iubmb/enzyme/EC3/1/3/81.html). However, reaction details are only provided for the cumulative enzymatic activity, therefore this term has not been split into two. synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] synonym: "diacylglycerol pyrophosphate phosphatase activity" EXACT [] xref: EC:3.1.3.81 xref: MetaCyc:RXN-11277 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rb, GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0031261 ! DNA replication preinitiation complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000812 name: Swr1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [GOC:rb, PMID:14645854, PMID:14690608, PMID:19355820] synonym: "SWR-C" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0097346 ! INO80-type complex [Term] id: GO:0000813 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000814 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000815 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "endosomal sorting complex required for transport" BROAD [] is_a: GO:0036452 ! ESCRT complex is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000817 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000818 name: nuclear MIS12/MIND complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] is_a: GO:0000444 ! MIS12/MIND type complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The cell cycle process in which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0051276 ! chromosome organization is_a: GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0000821 name: regulation of arginine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] synonym: "regulation of arginine metabolism" EXACT [] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process relationship: regulates GO:0006525 ! arginine metabolic process [Term] id: GO:0000822 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0043168 ! anion binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0000823 name: inositol-1,4,5-trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,4,5-trisphosphate + ATP = D-myo-inositol 1,4,5,6-tetrakisphosphate + ADP + 2 H(+)." [MetaCyc:2.7.1.151-RXN] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "inositol trisphosphate 6-kinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: EC:2.7.1.151 xref: KEGG:R05800 xref: MetaCyc:2.7.1.151-RXN is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0000824 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] xref: reactome:R-HSA-1855185 "I(1,4,5,6)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000825 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] xref: MetaCyc:RXN-7184 xref: reactome:R-HSA-1855206 "I(1,3,4,5)P4 is phosphorylated to I(1,3,4,5,6)P5 by IPMK in the nucleus" is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000826 name: obsolete inositol pyrophosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of inositol phosphates which possess diphosphate bonds." [GOC:elh, PMID:16429326] comment: This term was made obsolete because it is incorrectly defined; 'inositol pyrophosphate' is a inositol derivative to which one (or more) pyrophosphate moieties are attached. 'Inositol pyrophosphate synthase' refers to a class of enzymes that catalyze various different reactions that result in the formation of an IP, so one cannot formulate a general reaction for them. synonym: "inositol diphosphate synthase activity" EXACT [] synonym: "inositol pyrophosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0052746 [Term] id: GO:0000827 name: inositol-1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol tetrakisphosphate is unknown." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] xref: reactome:R-HSA-1855181 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/2 in the nucleus" xref: reactome:R-HSA-1855223 "I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000828 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + diphospho-1D-myo-inositol-pentakisphosphate. The isomeric configuration of diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) is unknown." [GOC:elh, GOC:vw, PMID:16429326] xref: reactome:R-HSA-1855207 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/2 in the nucleus" xref: reactome:R-HSA-1855216 "IP6 is phosphorylated to 1-PP-IP5 by PPIP5K1/2 in the cytosol" xref: reactome:R-HSA-1855227 "IP6 is phosphorylated to 5-PP-IP5 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000829 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate. The isomeric configurations of the diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5) and bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4) are unknown." [GOC:elh, PMID:16429326] xref: reactome:R-HSA-1855157 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/2 in the nucleus" xref: reactome:R-HSA-1855182 "5-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by PPIP5K1/2 in the cytosol" xref: reactome:R-HSA-1855194 "1-PP-IP5 is phosphorylated to 1,5-(PP)2-IP4 by IP6K1/3 in the cytosol" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000830 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000831 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000832 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,2,3,4,5,6-hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [MetaCyc:2.7.1.152-RXN] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] xref: EC:2.7.4.21 xref: KEGG:R09087 xref: MetaCyc:2.7.1.152-RXN is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000833 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000834 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0000829 ! inositol heptakisphosphate kinase activity [Term] id: GO:0000835 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000836 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p. In mammals, this complex contains the ubiquitin ligase HRD1 (Synoviolin) or AMFR (gp78)." [GOC:bf, GOC:elh, PMID:16619026, PMID:16873066, PMID:21454652] synonym: "HRD1 ubiquitin ligase complex" RELATED [GOC:bf] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000837 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membrane proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000838 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000839 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000900 name: translation repressor activity, mRNA regulatory element binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding (through a selective and non-covalent interaction) to nucleic acid." [GOC:clt, GOC:vw, PMID:29061112, PMID:7523370] comment: Changed term label as requested in https://github.com/geneontology/go-ontology/issues/15049 synonym: "translation repressor activity, nucleic acid binding" BROAD [] is_a: GO:0030371 ! translation repressor activity is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0000901 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process in which the size or shape of a cell is generated and organized." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cellular morphogenesis" EXACT [] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000903 name: obsolete regulation of cell shape during vegetative growth phase namespace: biological_process alt_id: GO:0090061 def: "OBSOLETE. Any process that modulates the surface configuration of a cell during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators, GOC:vw] comment: The reason for obsoletion is that biological phases should be captured as extensions. synonym: "cell morphogenesis during vegetative growth phase" RELATED [GOC:vw] synonym: "cellular morphogenesis during vegetative growth" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell morphogenesis during vegetative growth phase" RELATED [] is_obsolete: true [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000905 name: sporocarp development involved in asexual reproduction namespace: biological_process def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] synonym: "conidium development" NARROW [] synonym: "fruiting body formation involved in asexual reproduction" BROAD [] synonym: "haploid fruiting" RELATED [] synonym: "homokaryotic fruiting" RELATED [] synonym: "imperfect stage fruiting body development" NARROW [] synonym: "monokaryotic fruiting" RELATED [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone-4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:2.5.1.78 xref: MetaCyc:LUMAZINESYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000907 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = sulfite + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0000908 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + O(2) + taurine = aminoacetaldehyde + CO(2) + succinate + sulfite." [EC:1.14.11.17, RHEA:15909] synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: KEGG:R05320 xref: MetaCyc:RXN0-299 xref: RHEA:15909 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0000909 name: sporocarp development involved in sexual reproduction namespace: biological_process def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] synonym: "ascus development" NARROW [] synonym: "fruiting body development involved in sexual reproduction" BROAD [] synonym: "fruiting body formation involved in sexual reproduction" BROAD [] synonym: "perfect stage fruiting body development" NARROW [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 alt_id: GO:0033205 def: "The division of the cytoplasm and the plasma membrane of a cell and its partitioning into two daughter cells." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. When annotating eukaryotic species, mitotic or meiotic cytokinesis should always be specified for manual annotation and for prokaryotic species use 'FtsZ-dependent cytokinesis ; GO:0043093' or Cdv-dependent cytokinesis ; GO:0061639. Also, note that cytokinesis does not necessarily result in physical separation and detachment of the two daughter cells from each other. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell cycle cytokinesis" EXACT [] synonym: "cytokinesis involved in cell cycle" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Cytokinesis is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000911 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] is_a: GO:0000910 ! cytokinesis [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:mtg_cell_cycle] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis [Term] id: GO:0000913 name: preprophase band assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] synonym: "preprophase band formation" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000914 name: phragmoplast assembly namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] synonym: "phragmoplast formation" RELATED [goc:dph] is_a: GO:1902407 ! assembly of actomyosin apparatus involved in mitotic cytokinesis relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000915 name: actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring assembly" EXACT [] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cytokinesis is_a: GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0000916 name: actomyosin contractile ring contraction namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" BROAD [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" BROAD [GOC:dph, GOC:tb] is_a: GO:0036213 ! contractile ring contraction relationship: part_of GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0000917 name: division septum assembly namespace: biological_process alt_id: GO:0071937 alt_id: GO:1902411 def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material." [GOC:mtg_cell_cycle] synonym: "division septum assembly involved in cell cycle cytokinesis" NARROW [] synonym: "division septum assembly involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "division septum formation" EXACT [GOC:mah] synonym: "division septum formation involved in cell cycle cytokinesis" NARROW [] synonym: "division septum formation involved in cell cycle cytokinesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "division septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "formation of division septum" EXACT [] synonym: "formation of division septum involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "mitotic division septum assembly" NARROW [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum biosynthesis involved in mitotic cell cycle" NARROW [GOC:TermGenie] synonym: "septin assembly and septum formation" RELATED [] synonym: "septin assembly and septum formation involved in mitotic cell cycle" NARROW [GOC:TermGenie] is_a: GO:0090529 ! cell septum assembly [Term] id: GO:0000918 name: division septum site selection namespace: biological_process def: "The process of marking the site where a division septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "selection of site for division septum formation" EXACT [GOC:curators] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000917 ! division septum assembly [Term] id: GO:0000919 name: cell plate assembly namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] synonym: "cell plate formation" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000920 name: septum digestion after cytokinesis namespace: biological_process alt_id: GO:1902409 alt_id: GO:2000695 def: "The process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:vw] comment: This term should not be used to describe the last step of cytokinesis in organisms without a cell wall, ie, the cell resealing of the plasma membrane via abscission. Consider annotating to 'GO:0061952 midbody abscission' to capture this process. synonym: "cell separation after cytokinesis" RELATED [] synonym: "cell separation following cytokinesis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinetic cell separation" RELATED [] synonym: "daughter cell separation" RELATED [] synonym: "mitotic cytokinetic cell separation" BROAD [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0051301 ! cell division [Term] id: GO:0000921 name: septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] is_a: GO:0031106 ! septin ring organization is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0070925 ! organelle assembly [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center is_a: GO:0032155 ! cell division site part [Term] id: GO:0000924 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component alt_id: GO:0000925 alt_id: GO:0000926 def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] is_a: GO:0008274 ! gamma-tubulin ring complex relationship: part_of GO:0000242 ! pericentriolar material [Term] id: GO:0000927 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0008275 ! gamma-tubulin small complex [Term] id: GO:0000928 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins located in the spindle pole body and isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075] synonym: "Tub4 complex" EXACT [] is_a: GO:0008275 ! gamma-tubulin small complex relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0000930 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0000931 name: gamma-tubulin large complex namespace: cellular_component alt_id: GO:0000929 def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0000932 name: P-body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. Protein and RNA localized to these foci are involved in mRNA degradation, nonsense-mediated mRNA decay (NMD), translational repression, and RNA-mediated gene silencing." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "cytoplasmic mRNA processing body" EXACT [] synonym: "P body" EXACT [] xref: Wikipedia:P_body is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule [Term] id: GO:0000933 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] is_a: GO:0030428 ! cell septum [Term] id: GO:0000934 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000935 name: division septum namespace: cellular_component def: "A cell septum which forms as part of the division site and functions in the compartmentalization of a cell into two daughter cells at division. A division septum spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt, GOC:vw] synonym: "complete septum" EXACT [] synonym: "divison septum" EXACT [] is_a: GO:0030428 ! cell septum is_a: GO:0032155 ! cell division site part [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0000935 ! division septum [Term] id: GO:0000937 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] is_a: GO:0000934 ! porous cell septum [Term] id: GO:0000938 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0099023 ! tethering complex [Term] id: GO:0000939 name: condensed chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "inner kinetochore plate" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000940 name: condensed chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore of condensed chromosome" EXACT [GOC:curators] synonym: "outer kinetochore plate" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000941 name: condensed nuclear chromosome inner kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] synonym: "inner kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000939 ! condensed chromosome inner kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000942 name: condensed nuclear chromosome outer kinetochore namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] synonym: "outer kinetochore of condensed nuclear chromosome" EXACT [GOC:curators] is_a: GO:0000940 ! condensed chromosome outer kinetochore is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000943 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: Wikipedia:Virus-like_particle is_a: GO:0044428 ! nuclear part [Term] id: GO:0000947 name: amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0000948 name: amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0000949 name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000950 name: branched-chain amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to alcohol via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000951 name: methionine catabolic process to 3-methylthiopropanol namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000952 name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000953 name: branched-chain amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] synonym: "branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway" EXACT [GOC:krc] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009083 ! branched-chain amino acid catabolic process [Term] id: GO:0000954 name: methionine catabolic process to 3-methylthiopropanoate namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009087 ! methionine catabolic process is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000955 name: amino acid catabolic process via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000958 name: mitochondrial mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:1902369 ! negative regulation of RNA catabolic process relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing is_a: GO:0140053 ! mitochondrial gene expression [Term] id: GO:0000964 name: mitochondrial RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 5' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0000966 ! RNA 5'-end processing [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0000968 name: tRNA exon ligation namespace: biological_process def: "An RNA exon ligation process that rejoins two exons of a pre-tRNA which has had the intron removed." [GOC:krc] is_a: GO:0000378 ! RNA exon ligation relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000969 name: tRNA exon ligation utilizing ATP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000970 name: tRNA exon ligation utilizing GTP as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000971 name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate namespace: biological_process def: "A tRNA exon ligation process in which the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation [Term] id: GO:0000972 name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000973 name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The chromosome organization process in which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery [Term] id: GO:0000974 name: Prp19 complex namespace: cellular_component def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] synonym: "nineteen complex" NARROW [] synonym: "NTC" RELATED [] synonym: "Prp19/CDC5 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0000976 name: transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0044212 ! transcription regulatory region DNA binding is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0000977 name: RNA polymerase II regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001012 ! RNA polymerase II regulatory region DNA binding [Term] id: GO:0000978 name: RNA polymerase II proximal promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a gene transcribed by RNA polymerase II. The proximal promoter is in cis with and relatively close to the core promoter." [GOC:pg, GOC:txnOH] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer". synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase II promoter proximal region sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase II upstream activating sequence (UAS) sequence-specific DNA binding" RELATED [] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0000987 ! proximal promoter sequence-specific DNA binding [Term] id: GO:0000979 name: RNA polymerase II core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a RNA polymerase II-transcribed gene." [GOC:pg, GOC:txnOH, PMID:12381658] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000980 name: RNA polymerase II distal enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase II (Pol II) distal enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of some promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH] comment: Note that distal enhancers of the type found in mammalian cells are not known to occur in either Saccharomyces cerevisiae or Schizosaccharomyces pombe. While some S. cerevisiae literature does refer to sequences distal to the initiation site, these distal sites do not seem to function independently of position or orientation as mammalian distal enhancers do and are not considered to be enhancers. is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0000981 name: DNA-binding transcription factor activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0000982 alt_id: GO:0001133 alt_id: GO:0001200 alt_id: GO:0001201 alt_id: GO:0001202 alt_id: GO:0001203 alt_id: GO:0003705 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15530 and https://github.com/geneontology/go-ontology/issues/16152; changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "RNA polymerase II transcription factor activity, copper ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase II transcription factor activity, sequence-specific transcription regulatory region DNA binding" EXACT [] synonym: "RNA polymerase II transcription factor activity, zinc ion regulated core promoter proximal region sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity" NARROW [] synonym: "sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] synonym: "sequence-specific transcription regulatory region DNA binding RNA polymerase II transcription factor recruiting transcription factor activity" RELATED [] synonym: "transcription factor" BROAD [GOC:vw] synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] synonym: "transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity" NARROW [] is_a: GO:0003700 ! DNA-binding transcription factor activity [Term] id: GO:0000984 name: bacterial-type RNA polymerase regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase." [GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". synonym: "eubacterial-type RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001017 ! bacterial-type RNA polymerase regulatory region DNA binding [Term] id: GO:0000985 name: bacterial-type RNA polymerase core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA sequence that is part of the core promoter of a bacterial gene." [GOC:pg, GOC:txnOH] synonym: "eubacterial-type RNA polymerase core promoter sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001046 ! core promoter sequence-specific DNA binding [Term] id: GO:0000986 name: bacterial-type proximal promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter of a bacterial gene (or cistron, or operon). The proximal promoter is in cis with and relatively close to the core promoter." [GOC:pg, GOC:txnOH] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding" EXACT [] synonym: "eubacterial-type RNA polymerase regulatory transcription factor sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0000987 ! proximal promoter sequence-specific DNA binding [Term] id: GO:0000987 name: proximal promoter sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001159 def: "Interacting selectively and non-covalently with a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in the proximal promoter. The proximal promoter is in cis with and relatively close to the core promoter." [GOC:pg, GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". synonym: "core promoter proximal region DNA binding" RELATED [] synonym: "core promoter proximal region sequence-specific DNA binding" EXACT [] synonym: "promoter proximal region sequence-specific DNA binding" EXACT [] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding [Term] id: GO:0000988 name: obsolete transcription factor activity, protein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "protein binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] is_obsolete: true consider: GO:0005515 consider: GO:0140110 [Term] id: GO:0000989 name: obsolete transcription factor activity, transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "transcription factor binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0008134 consider: GO:0140110 [Term] id: GO:0000990 name: obsolete transcription factor activity, core RNA polymerase binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "core RNA polymerase binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0043175 consider: GO:0140110 [Term] id: GO:0000991 name: obsolete transcription factor activity, core RNA polymerase II binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "core RNA polymerase II binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000993 consider: GO:0140110 [Term] id: GO:0000992 name: polymerase III regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a regulatory region that controls transcription by RNA polymerase III. The transcribed region might be contain a single gene or a cistron containing multiple genes." [GOC:txnOH, PMID:12381659] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0000993 name: RNA polymerase II complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits." [GOC:txnOH] synonym: "RNA polymerase II core binding" EXACT [] synonym: "RNAP II core binding" EXACT [] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000994 name: RNA polymerase III core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase III core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0000995 name: RNA polymerase III general transcription initiation factor activity namespace: molecular_function alt_id: GO:0001034 def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase III. Factors required for RNA polymerase III transcription initiation include TFIIIA, TFIIIB and TFIIIC." [GOC:txnOH-2018, PMID:12381659, Wikipedia:RNA_polymerase_III] comment: Changed label, definition, see https://github.com/geneontology/go-ontology/issues/15789 synonym: "core RNA polymerase III binding transcription factor activity" NARROW [] synonym: "RNA polymerase III general initiation factor activity" EXACT [] synonym: "RNA polymerase III transcription factor activity, sequence-specific DNA binding" NARROW [] synonym: "sequence-specific DNA binding RNA polymerase III transcription factor activity" NARROW [] synonym: "transcription factor activity, core RNA polymerase III binding" NARROW [] is_a: GO:0140223 ! general transcription initiation factor activity [Term] id: GO:0001000 name: bacterial-type RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one omega subunit." [GOC:txnOH] comment: Should omega be included here? synonym: "eubacterial-type RNA polymerase core enzyme binding" EXACT [] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001001 name: mitochondrial single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit mitochondrial RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995, PMID:2088182] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001002 name: RNA polymerase III type 1 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001030 ! RNA polymerase III type 1 promoter DNA binding [Term] id: GO:0001003 name: RNA polymerase III type 2 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001031 ! RNA polymerase III type 2 promoter DNA binding [Term] id: GO:0001004 name: RNA polymerase III transcription regulator recruiting activity namespace: molecular_function alt_id: GO:0001005 alt_id: GO:0001008 alt_id: GO:0001033 alt_id: GO:0001038 alt_id: GO:0001157 def: "Initiating the assembly of the RNA polymerase III pre-initiation complex by binding to a control sequence in the intragenic region. This allows to recruit TFIIIB to the DNA at a site centered approximately 26 base pairs upstream of the start site of transcription. For tRNA genes, TFIIIC first associates with DNA, and then recruits TFIIIB. For 5S rRNA genes, TFIIIA binds to DNA first, followed by TFIIIC, which then recruits TFIIIB." [GOC:txnOH-2018, PMID:12381659, PMID:23063749, PMID:27911719, Wikipedia:RNA_polymerase_III] comment: Merged terms as in https://github.com/geneontology/go-ontology/issues/14852 synonym: "RNA polymerase III assembly factor activity" RELATED [] synonym: "RNA polymerase III assembly factor activity, TFIIIB recruiting" RELATED [] synonym: "RNA polymerase III hybrid type promoter TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III type 2 promoter sequence-specific DNA binding TFIIIB recruiting transcription factor activity" NARROW [] synonym: "RNA polymerase III type 3 promoter TFIIIB recruiting transcription factor activity" NARROW [] synonym: "SNAPc-type activity" RELATED [] synonym: "TFIIIA activity" RELATED [] synonym: "TFIIIC-type activity" RELATED [] synonym: "transcription factor activity, RNA polymerase III promoter sequence-specific binding, TFIIIB recruiting" EXACT [] synonym: "transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] synonym: "transcription factor activity, RNA polymerase III type 1 promoter TFIIIB" RELATED [] synonym: "transcription factor activity, RNA polymerase III type 2 promoter sequence-specific binding, TFIIIB recruiting" NARROW [] synonym: "transcription factor activity, RNA polymerase III type 3 promoter TFIIIB recruiting" NARROW [] synonym: "type 2 RNA polymerase III promoter recognition" NARROW [] synonym: "type 3 RNA polymerase III promoter recognition" NARROW [] is_a: GO:0001134 ! transcription regulator recruiting activity [Term] id: GO:0001006 name: RNA polymerase III type 3 promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III (Pol III). A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001032 ! RNA polymerase III type 3 promoter DNA binding [Term] id: GO:0001007 name: obsolete transcription factor activity, RNA polymerase III transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase III transcription factor binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001010 name: RNA polymerase II sequence-specific DNA-binding transcription factor recruiting activity namespace: molecular_function def: "The function of binding to a specific DNA sequence and recruiting another transcription factor to the DNA in order to modulate transcription. The recruited factor may bind DNA directly, or may be colocalized via protein-protein interactions." [GOC:txnOH] synonym: "sequence-specific DNA binding transcription factor recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, sequence-specific DNA binding transcription factor recruiting" EXACT [] synonym: "transcription factor activity, sequence-specific DNA-binding transcription factor recruiting" RELATED [] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0001011 name: obsolete transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence and recruiting RNA polymerase to the DNA in order to form the preinitiation complex (PIC)." [GOC:txnOH] comment: This term was obsoleted because it was not clearly defined and usage has been inconsistent. synonym: "sequence-specific DNA binding RNA polymerase recruiting transcription factor activity" EXACT [] is_obsolete: true consider: GO:0140223 [Term] id: GO:0001012 name: RNA polymerase II regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase II. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001013 name: RNA polymerase I regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by RNA polymerase I. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001014 name: snoRNA transcription by RNA polymerase III namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase III, originating at a type 2 RNA polymerase III promoter." [GOC:txnOH] synonym: "snoRNA transcription from a type 2 RNA polymerase III promoter" NARROW [] is_a: GO:0006383 ! transcription by RNA polymerase III is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001015 name: snoRNA transcription by RNA polymerase II namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template by RNA polymerase II, originating at an RNA polymerase II promoter." [GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "snoRNA transcription from an RNA polymerase II promoter" EXACT [] is_a: GO:0006366 ! transcription by RNA polymerase II is_a: GO:0009302 ! snoRNA transcription [Term] id: GO:0001016 name: RNA polymerase III regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene by RNA polymerase III. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw, PMID:12381659] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001017 name: bacterial-type RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a gene or operon by a bacterial-type RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] synonym: "eubacterial-type RNA polymerase regulatory region DNA binding" EXACT [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001018 name: mitochondrial promoter sequence-specific DNA binding namespace: molecular_function alt_id: GO:0000997 alt_id: GO:0001044 alt_id: GO:0001045 alt_id: GO:0070361 alt_id: GO:0070362 alt_id: GO:0070363 alt_id: GO:0070364 def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of the mitochondrial DNA." [GOC:txnOH, GOC:vw, PMID:20056105] synonym: "HSP coding strand binding" NARROW [PMID:9485316] synonym: "HSP non-coding strand binding" NARROW [PMID:9485316] synonym: "HSPas binding" NARROW [PMID:9485316] synonym: "HSPs binding" NARROW [PMID:9485316] synonym: "LSP coding strand binding" NARROW [PMID:9485316] synonym: "LSP non-coding strand binding" NARROW [PMID:9485316] synonym: "LSPas binding" NARROW [PMID:9485316] synonym: "LSPs binding" NARROW [PMID:9485316] synonym: "mitochondrial heavy strand promoter anti-sense binding" NARROW [] synonym: "mitochondrial heavy strand promoter sense binding" NARROW [] synonym: "mitochondrial light strand promoter anti-sense binding" NARROW [] synonym: "mitochondrial light strand promoter sense binding" NARROW [] synonym: "mitochondrial proximal promoter sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase core promoter proximal region sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase core promoter sequence-specific DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase regulatory region DNA binding" RELATED [] synonym: "mitochondrial RNA polymerase regulatory region sequence-specific DNA binding" RELATED [] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001019 name: plastid RNA polymerase regulatory region DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a DNA region that controls the transcription of a region of DNA by a plastid RNA polymerase. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH, GOC:vw] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001025 name: RNA polymerase III general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor, any protein required to initiate or regulate transcription by RNA polymerase III." [GOC:txnOH] synonym: "RNA polymerase III transcription factor binding" BROAD [] is_a: GO:0140296 ! general transcription initiation factor binding [Term] id: GO:0001026 name: obsolete TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way, Once recruited to an RNA polymerase III promoter by one or more other transcription factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH] comment: This term was obsoleted because it represents a gene product. synonym: "RNA polymerase III recruiting transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001027 name: obsolete RNA polymerase III type 1 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 1 promoter by TFIIIA-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. synonym: "RNA polymerase III type 1 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true [Term] id: GO:0001028 name: obsolete RNA polymerase III type 2 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 2 promoter by a TFIIIC-type factor, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. synonym: "RNA polymerase III type 2 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true [Term] id: GO:0001029 name: obsolete RNA polymerase III type 3 promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III type 3 promoter by SNAP-type and TFIIIC-type factors, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] synonym: "RNA polymerase III type 3 promoter polymerase recruiting transcription factor activity" RELATED [] is_obsolete: true [Term] id: GO:0001030 name: RNA polymerase III type 1 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 1 promoter that controls transcription by RNA polymerase III. Type 1 promoters are found in 5S rRNA genes, downstream of the transcription start site within the sequence of the mature RNA, and require TFIIIA for recognition." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding is_a: GO:0080084 ! 5S rDNA binding [Term] id: GO:0001031 name: RNA polymerase III type 2 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 2 promoter that controls transcription by RNA polymerase III. Type 2 promoters consist of an A box and a B box downstream of the transcription start site within the sequence within the sequence of the mature RNA. Type 2 promoters are found in many tRNA genes as well as in other small RNAs." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001032 name: RNA polymerase III type 3 promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a type 3 promoter that controls transcription by RNA polymerase III. A type 3 Pol III promoter is composed of elements upstream of the transcription start site, including a TATA box. The human U6 snRNA gene has a type 3 promoter. Type 3 Pol III promoters have not been observed in S. cerevisiae." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001037 name: RNA polymerase III hybrid type promoter DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that is a part of a hybrid promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0001016 ! RNA polymerase III regulatory region DNA binding [Term] id: GO:0001039 name: RNA polymerase III hybrid type promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a part of a hybrid type promoter that controls transcription by RNA polymerase III (Pol III). A hybrid Pol III promoter contains both regulatory elements both upstream and downstream of the transcription initiation site. An example gene with such a promoter is the S. cerevisiae U6 gene." [GOC:txnOH, PMID:12381659] is_a: GO:0000992 ! polymerase III regulatory region sequence-specific DNA binding is_a: GO:0001037 ! RNA polymerase III hybrid type promoter DNA binding [Term] id: GO:0001040 name: obsolete RNA polymerase III hybrid type promoter TFIIIB-type transcription factor activity namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase III (Pol III) complex, typically composed of seventeen subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way. Once recruited to an RNA polymerase III hybrid type promoter, binds to DNA, recruits RNA polymerase III and facilitates the transition from the closed to the open complex." [GOC:txnOH-2018, PMID:12381659] comment: The reason for obsoletion is that there is a single TFIIIB activity; this is not dependent on the promoter. is_obsolete: true [Term] id: GO:0001042 name: RNA polymerase I core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase I core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of seventeen subunits." [GOC:txnOH] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001046 name: core promoter sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is part of a core promoter region. The core promoter is composed of the transcription start site and binding sites for the RNA polymerase and the basal transcription machinery. The transcribed region might be described as a gene, cistron, or operon." [GOC:pg, GOC:txnOH] comment: The word "promoter" is used variously in the literature to describe the core promoter specifically or the entire proximal regulatory region (excluding any distal enhancers) including both the core promoter and the upstream region where activating transcription factors such as Gal4 in S. cerevisiae or catabolite activator protein (CAP) in E. coli bind. To minimize ambiguity in the use of the word "promoter" in GO, we have chosen the phrase "transcription regulatory region" in order to refer to all of the regulatory regions. Regulatory regions in the DNA which control initiation may include the "core promoter" where the basal transcription machinery binds, the "core promoter proximal region" where regulatory factors other than the basal machinery bind, and "enhancer" regions which are typically more distal from the core promoter. There are also additional regulatory regions, in both the DNA and the RNA transcript, which regulate elongation or termination of transcription. ANNOTATION NOTE: Regarding annotation to "transcription regulatory region DNA binding" (GO:0044212) and any of its is_a children, note that annotation to these terms specifies DNA binding only without any statement about transcription factor activity. To make an annotation about a function of transcription factor activity, consider "sequence-specific DNA-binding transcription factor activity" (GO:0003700) or its is_a children which have has_part relationships to the appropriate kind of "transcription regulatory region DNA binding". is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001047 ! core promoter binding [Term] id: GO:0001047 name: core promoter binding namespace: molecular_function def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for the basal transcription machinery. Binding may occur as a sequence specific interaction or as an interaction observed only once a factor has been recruited to the DNA by other factors." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001048 name: RNA polymerase IV core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase IV core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in siRNA production." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001049 name: RNA polymerase V core binding namespace: molecular_function def: "Interacting selectively and non-covalently with RNA polymerase V core enzyme, a multisubunit eukaryotic nuclear RNA polymerase found in plants and involved in production of noncoding transcripts at target loci for silencing." [GOC:txnOH, PMID:19110459] is_a: GO:0043175 ! RNA polymerase core enzyme binding [Term] id: GO:0001050 name: single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] synonym: "SP6-type RNA polymerase binding" EXACT [] synonym: "T3-type RNA polymerase binding" EXACT [] synonym: "T3/T7 type RNA polymerase binding" EXACT [] synonym: "T7-type RNA polymerase binding" EXACT [] is_a: GO:0070063 ! RNA polymerase binding [Term] id: GO:0001051 name: plastid single-subunit type RNA polymerase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a single subunit plastid RNA polymerase enzyme, which is composed of a single catalytic subunit similar to the RNA polymerase enzymes from phages T3, T7, and SP6." [GOC:txnOH, PMID:20701995] is_a: GO:0001050 ! single-subunit type RNA polymerase binding [Term] id: GO:0001052 name: plastid PEP RNA polymerase core enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the bacterial-type plastid PEP RNA polymerase core enzyme, typically consisting of two alpha, one beta, one beta prime, and one double prime subunit." [GOC:txnOH, PMID:20701995] is_a: GO:0001000 ! bacterial-type RNA polymerase core enzyme binding [Term] id: GO:0001054 name: RNA polymerase I activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase I specific promoter to direct initiation and catalyzes DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001055 name: RNA polymerase II activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase II promoter" EXACT [] xref: reactome:R-HSA-6814549 "Pre-snRNA transcript initiation, Integrator binding, LEC binding" xref: reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001056 name: RNA polymerase III activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase III specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase III promoter" EXACT [] xref: reactome:R-HSA-1964482 "RNA polymerase III transcribes microbial dsDNA to dsRNA" is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001057 name: RNA polymerase IV activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase IV specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001058 name: RNA polymerase V activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains an RNA polymerase V specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "DNA-directed RNA polymerase activity involved in transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001059 name: transcription by RNA polymerase IV namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase IV, originating at a Pol IV-specific promoter." [GOC:txnOH, PMID:19110459] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from RNA pol IV promoter" EXACT [] synonym: "transcription from RNA polymerase IV promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0001060 name: transcription by RNA polymerase V namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase V, originating at a Pol V-specific promoter." [GOC:txnOH, PMID:19110459] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from RNA pol V promoter" EXACT [] synonym: "transcription from RNA polymerase V promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0001061 name: bacterial-type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a bacterial-type specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001062 name: plastid PEP-A RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-A RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001063 name: plastid PEP-B RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a plastid PEP-B RNA polymerase II specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001061 ! bacterial-type RNA polymerase activity [Term] id: GO:0001064 name: single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] synonym: "T3/T7 type RNA polymerase activity" EXACT [] is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0001065 name: mitochondrial single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single-subunit-type mitochondrial RNA polymerase-specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001066 name: plastid single subunit type RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template that contains a single subunit type plastid RNA polymerase specific promoter to direct initiation and catalyses DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [GOC:txnOH, PMID:20701995] is_a: GO:0001064 ! single subunit type RNA polymerase activity [Term] id: GO:0001067 name: regulatory region nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0001068 name: transcription regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region within the transcript that regulates the transcription of a region of DNA, which may be a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0001069 ! regulatory region RNA binding [Term] id: GO:0001069 name: regulatory region RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair." [GOC:txnOH] is_a: GO:0001067 ! regulatory region nucleic acid binding is_a: GO:0003723 ! RNA binding [Term] id: GO:0001070 name: RNA-binding transcription regulator activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA sequence in order to modulate transcription. This function is known to occur in phages and viruses, for example the lambda N and the HIV tat proteins are necessary to allow RNA polymerase to read through terminator sequences." [GOC:txnOH-2018, PMID:1756726] comment: Added taxon constraints, edited definition see https://github.com/geneontology/go-ontology/issues/15872 synonym: "RNA binding transcription factor activity" RELATED [] synonym: "RNA binding transcription regulator activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0001072 name: transcription antitermination factor activity, RNA binding namespace: molecular_function def: "Binds to RNA, typically within the nascent RNA transcript, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind the nascent RNA include the lambda N protein and the HIV-1 tat protein." [GOC:txnOH, PMID:8332211] synonym: "RNA binding transcription antitermination factor activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0001073 name: transcription antitermination factor activity, DNA binding namespace: molecular_function def: "Binds to DNA, typically within region of the promoter and transcribed region, to promote readthrough of a transcription termination site and thus extending the length of the RNA transcript produced. Examples of antitermination factors which bind DNA include the lambda Q protein." [GOC:txnOH, PMID:8332211] synonym: "DNA binding transcription antitermination factor activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0001074 name: obsolete transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase II (RNAP II) in order to promote assembly of the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase II promoter." [GOC:txnOH] comment: This term has been obsoleted because it represents a GO-CAM model, see https://github.com/geneontology/go-ontology/issues/16554 synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" EXACT [] synonym: "transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding involved in preinitiation complex assembly" EXACT [] is_obsolete: true [Term] id: GO:0001076 name: obsolete transcription factor activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001085 consider: GO:0140110 [Term] id: GO:0001079 name: nitrogen catabolite regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0090293 ! nitrogen catabolite regulation of transcription [Term] id: GO:0001080 name: nitrogen catabolite activation of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "positive regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090294 ! nitrogen catabolite activation of transcription [Term] id: GO:0001081 name: nitrogen catabolite repression of transcription from RNA polymerase II promoter namespace: biological_process def: "A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources." [GOC:mah, GOC:txnOH, PMID:19104072] synonym: "negative regulation of transcription from RNA polymerase II promoter by nitrogen catabolites" EXACT [GOC:mah] is_a: GO:0001079 ! nitrogen catabolite regulation of transcription from RNA polymerase II promoter is_a: GO:0090295 ! nitrogen catabolite repression of transcription [Term] id: GO:0001082 name: obsolete transcription factor activity, RNA polymerase I transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase I transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase I transcription factor binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001083 name: obsolete transcription factor activity, RNA polymerase II basal transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, which may be a single protein or a complex, in order to modulate transcription. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "RNA polymerase II basal transcription factor binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001084 name: obsolete transcription factor activity, TFIID-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIID class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIID-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001094 [Term] id: GO:0001085 name: RNA polymerase II transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription factor, any protein required to initiate or regulate transcription by RNA polymerase II." [GOC:txnOH] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001086 name: obsolete transcription factor activity, TFIIA-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIA class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIA-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001092 [Term] id: GO:0001087 name: obsolete transcription factor activity, TFIIB-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIB class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIB-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001093 [Term] id: GO:0001088 name: obsolete transcription factor activity, TFIIE-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIE class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIE-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001095 [Term] id: GO:0001089 name: obsolete transcription factor activity, TFIIF-class transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIF class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIF-class binding transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001096 [Term] id: GO:0001090 name: obsolete transcription factor activity, TFIIH-class binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor of the TFIIH class in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. synonym: "TFIIH-class binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001091 name: RNA polymerase II general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a basal RNA polymerase II transcription factor, any of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:txnOH, PMID:16858867] synonym: "RNA polymerase II basal transcription factor binding" EXACT [] is_a: GO:0001099 ! basal RNA polymerase II transcription machinery binding is_a: GO:0140296 ! general transcription initiation factor binding [Term] id: GO:0001092 name: TFIIA-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIA complex, one of the complexes involved in formation of the preinitiation complex (PIC) by RNA polymerase II and defined as a basal or general transcription factor." [GOC:krc, PMID:16858867] synonym: "TFIIA-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001093 name: TFIIB-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor of the TFIIB class, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding [Term] id: GO:0001094 name: TFIID-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIID complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIID-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001095 name: TFIIE-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIE complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIE-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001096 name: TFIIF-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIF complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIF-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001097 name: TFIIH-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase II transcription factor belonging to the TFIIH complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase II." [GOC:krc, PMID:16858867] synonym: "TFIIH-class transcription factor binding" EXACT [] is_a: GO:0001091 ! RNA polymerase II general transcription initiation factor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0001098 name: basal transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of the RNA polymerase core enzyme and the basal transcription factor(s), the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. is_a: GO:0005515 ! protein binding [Term] id: GO:0001099 name: basal RNA polymerase II transcription machinery binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery for RNA polymerase II which is composed of the RNA polymerase II core enzyme, a multisubunit eukaryotic nuclear RNA polymerase typically composed of twelve subunits, and the basal RNA polymerase II transcription factors, the minimal set of factors required for formation of the preinitiation complex (PIC) by the RNA polymerase." [GOC:txnOH] comment: Note that the definition of basal, or general, transcription factors has typically been done at a small number of well characterized activator-independent promoters. At an activator-dependent promoter, one or more additional factors are generally required in addition to the basal factors. synonym: "basal RNAP II transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001100 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0045839 ! negative regulation of mitotic nuclear division is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition relationship: negatively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0001101 name: response to acid chemical namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form." [GOC:go_curators, GOC:rn, http://en.wikipedia.org/wiki/Acid] comment: This term should be used to describe a response to a specific acid as a chemical. E.g., if an organism were responding to glutamate, then the response would be glutamate-specific; the organism is actually responding to the chemical structure of the anion portion of the dissociated acid. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. If annotating experiments where an acid is playing a role as a proton donor, please annotate to GO:0010447 'response to acidic pH' instead. subset: gocheck_do_not_manually_annotate synonym: "response to acid" BROAD [] synonym: "response to acid anion" RELATED [] synonym: "response to oxoanion" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0001102 name: RNA polymerase II activating transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription activating factor, a protein involved in positive regulation of transcription." [GOC:txnOH] is_a: GO:0033613 ! activating transcription factor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0001103 name: RNA polymerase II repressing transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription repressing factor, a protein involved in negative regulation of transcription." [GOC:txnOH] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding is_a: GO:0070491 ! repressing transcription factor binding [Term] id: GO:0001108 name: bacterial-type RNA polymerase holo enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with the basal transcription machinery which is composed of a bacterial-type RNA polymerase core enzyme and a sigma factor, the minimal set of factors required for formation of the preinitiation complex (PIC) by a bacterial-type RNA polymerase." [GOC:txnOH] synonym: "basal bacterial-type RNA polymerase transcription machinery binding" EXACT [] is_a: GO:0001098 ! basal transcription machinery binding [Term] id: GO:0001109 name: promoter clearance during DNA-templated transcription namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by a DNA-dependent RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "promoter clearance during DNA-dependent transcription" EXACT [GOC:txnOH] synonym: "promoter escape" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0001110 name: promoter clearance from RNA polymerase III promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase III, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0001111 name: promoter clearance from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase II, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH, PMID:15020047] synonym: "promoter escape from RNA polymerase II promoter" EXACT [] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0001112 name: DNA-templated transcriptional open complex formation namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "DNA-dependent transcriptional open complex formation" EXACT [GOC:txnOH] synonym: "promoter melting" BROAD [] is_a: GO:0001120 ! protein-DNA complex remodeling relationship: part_of GO:0006352 ! DNA-templated transcription, initiation [Term] id: GO:0001113 name: transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:15020047, PMID:18280161] synonym: "RNA polymerase II promoter melting" EXACT [] is_a: GO:0001112 ! DNA-templated transcriptional open complex formation relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0001114 name: protein-DNA-RNA complex namespace: cellular_component def: "A macromolecular complex containing protein, DNA, and RNA molecules." [GOC:txnOH] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0001115 name: protein-DNA-RNA complex subunit organization namespace: biological_process def: "Any process in which macromolecules aggregate, disaggregate, or are modified, resulting in the formation, disassembly, or alteration of a protein-DNA-RNA complex." [GOC:txnOH] synonym: "protein-DNA-RNA complex subunit organisation" EXACT [GOC:mah] is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0001116 name: protein-DNA-RNA complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins, DNA, and RNA molecules to form a protein-DNA-RNA complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0001117 name: protein-DNA-RNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA-RNA complex into its constituent components." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0032984 ! protein-containing complex disassembly [Term] id: GO:0001118 name: transcription ternary complex disassembly namespace: biological_process def: "The disaggregation of a transcription ternary complex, composed of RNA polymerase, template DNA, and an RNA transcript, into its constituent components." [GOC:txnOH] synonym: "transcription protein-DNA-RNA complex disassembly" EXACT [] is_a: GO:0001117 ! protein-DNA-RNA complex disassembly relationship: part_of GO:0006353 ! DNA-templated transcription, termination [Term] id: GO:0001119 name: protein-DNA-RNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a protein-DNA-RNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0001115 ! protein-DNA-RNA complex subunit organization is_a: GO:0034367 ! protein-containing complex remodeling [Term] id: GO:0001120 name: protein-DNA complex remodeling namespace: biological_process def: "The acquisition, loss, or modification of macromolecules within a protein-DNA complex, resulting in the alteration of an existing complex." [GOC:txnOH] is_a: GO:0034367 ! protein-containing complex remodeling is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0001121 name: bacterial transcription namespace: biological_process def: "The synthesis of RNA from a DNA template by a bacterial-type RNA polymerase, originating at a bacterial-type promoter." [GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0001122 name: promoter clearance from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phase of transcription by a bacterial-type RNA polymerase, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance generally involves dissociation of the sigma initiation factor." [GOC:txnOH, PMID:18280161] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0001121 ! bacterial transcription [Term] id: GO:0001123 name: transcription initiation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the assembly of bacterial-type RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:txnOH, PMID:18280161] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0001121 ! bacterial transcription [Term] id: GO:0001124 name: transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a bacterial-type RNA polymerase promoter by the addition of ribonucleotides catalyzed by a bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] synonym: "RNA elongation from bacterial-type RNA polymerase promoter" EXACT [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0001121 ! bacterial transcription [Term] id: GO:0001125 name: transcription termination from bacterial-type RNA polymerase promoter namespace: biological_process def: "The process in which the synthesis of an RNA molecule by a bacterial-type RNA polymerase using a DNA template is completed." [GOC:txnOH, PMID:18280161] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0001121 ! bacterial transcription [Term] id: GO:0001126 name: bacterial-type RNA polymerase preinitiation complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on a bacterial-type RNA polymerase promoter DNA to form the transcriptional preinitiation complex (PIC), required for transcription." [GOC:txnOH, PMID:18280161] synonym: "bacterial-type RNA polymerase transcription PIC biosynthesis" EXACT [] synonym: "bacterial-type RNA polymerase transcription PIC formation" EXACT [] synonym: "bacterial-type RNA polymerase transcriptional preinitiation complex formation" EXACT [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001127 name: transcriptional open complex formation at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the melting of the DNA hybrid of the core promoter region within a bacterial-type RNA polymerase promoter to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH, PMID:18280161] is_a: GO:0001112 ! DNA-templated transcriptional open complex formation relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001128 name: obsolete RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II (RNAP II) regulatory transcription factor and also with the RNAP II basal transcription machinery in order to increase the frequency, rate or stability of the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC). Cofactors generally do not bind DNA, but rather mediate protein-protein interactions between activating transcription factors and the basal RNAP II transcription machinery." [GOC:txnOH, PMID:16858867] comment: This term was obsoleted because it represented a mix of function and process and is not annotated consistently synonym: "RNA polymerase II transcription coactivator activity involved in preinitiation complex assembly" EXACT [] is_obsolete: true [Term] id: GO:0001129 name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding, involved in preinitiation complex assembly namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), to facilitate the aggregation, arrangement and bonding together of proteins on RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" NARROW [] synonym: "TBP-class protein binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" EXACT [] is_obsolete: true [Term] id: GO:0001132 name: obsolete RNA polymerase II transcription factor activity, TBP-class protein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs), in order to modulate transcription. The transcription factor may or may not also interact selectively with DNA as well." [GOC:txnOH, PMID:16858867] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "TATA-binding protein binding RNA polymerase II transcription factor activity" NARROW [] synonym: "TBP-class protein binding RNA polymerase II transcription factor activity" EXACT [] synonym: "TRF protein binding RNA polymerase II transcription factor activity" NARROW [] is_obsolete: true [Term] id: GO:0001134 name: transcription regulator recruiting activity namespace: molecular_function def: "The function of binding to an RNA polymerase (RNAP) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] comment: Changed subclasses https://github.com/geneontology/go-ontology/issues/15577 synonym: "transcription factor activity, transcription factor recruiting" RELATED [] synonym: "transcription factor recruiting activity" EXACT [] synonym: "transcription factor recruiting transcription factor activity" EXACT [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0001135 name: RNA polymerase II transcription regulator recruiting activity namespace: molecular_function alt_id: GO:0001136 alt_id: GO:0001137 alt_id: GO:0001138 def: "The function of binding to an RNA polymerase II (RNAP II) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:16858867] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15795 synonym: "RNA polymerase II transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase II transcription factor recruiting transcription factor activity" EXACT [] synonym: "TFIIE-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "TFIIF-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "TFIIH-class transcription factor recruiting transcription factor activity" NARROW [] synonym: "transcription factor activity, RNA polymerase II transcription factor recruiting" RELATED [] synonym: "transcription factor activity, TFIIE-class transcription factor recruiting" NARROW [] synonym: "transcription factor activity, TFIIF-class transcription factor recruiting" NARROW [] synonym: "transcription factor activity, TFIIH-class transcription factor recruiting" NARROW [] is_a: GO:0001134 ! transcription regulator recruiting activity [Term] id: GO:0001139 name: RNA polymerase II complex recruiting activity namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II (Pol II) complex, typically composed of twelve subunits, and with another protein, macromolecule, or complex, permitting those molecules to function in a coordinated way in order to facilitate the aggregation, arrangement and bonding together of proteins on an RNA polymerase II promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription by RNA polymerase." [GOC:txnOH, PMID:16858867] synonym: "core RNA polymerase II recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, core RNA polymerase II recruiting" RELATED [] is_a: GO:0000993 ! RNA polymerase II complex binding [Term] id: GO:0001145 name: mitochondrial RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001146 def: "Interacting selectively and non-covalently with a DNA sequence that controls mitochondrial transcription termination." [GOC:txnOH-2018, PMID:18391175] synonym: "mitochondrial RNA polymerase terminator site sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity, mitochondrial RNA polymerase terminator site sequence-specific binding" EXACT [] is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001147 name: transcription termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH, PMID:18280161, PMID:18391175] comment: Transcription termination sites can be recognized by the RNA polymerase (RNAP) itself or by another protein which interacts with the RNAP to promote transcription termination. Note that not all genes have a specific sequence that functions as a termination site; for most mRNAs transcribed by RNAP II termination is not mediated by a specific termination sequence, but is coupled to polyadenylation. is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0001160 ! transcription termination site DNA binding [Term] id: GO:0001148 name: bacterial-type RNA polymerase termination site sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is a terminator for bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001147 ! transcription termination site sequence-specific DNA binding [Term] id: GO:0001149 name: obsolete transcription factor activity, bacterial-type RNA polymerase termination site sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a sequence of DNA that is a termination site for bacterial-type RNA polymerase in order to promote transcription termination by bacterial-type RNA polymerase." [GOC:txnOH, PMID:18280161] comment: This term was obsoleted because it was not clearly defined, see https://github.com/geneontology/go-ontology/issues/16730 synonym: "bacterial-type RNA polymerase termination site sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001150 name: bacterial-type RNA polymerase enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of DNA that is an enhancer region that helps activate transcription of a gene or operon by a bacterial-type RNA polymerase. Enhancers for sigma-54 holoenzymes are typically located 80 to 150 base pairs upstream from the transcription start site, although they can be further away or may be downstream of the promoter. Some transcription units dependent on sigma-70 holoenzymes may also include enhancer sequences." [GOC:txnOH, PMID:11282468, PMID:20629756] comment: Note that the phrase "upstream activating sequence", or UAS is often used in S. cerevisiae literature to refer to regulatory sequences that occur in the region upstream and proximal to the core promoter. In contrast, in bacteria such as E. coli, the phrase "upstream activating sequence", or UAS is a synonym for "enhancer". synonym: "bacterial-type RNA polymerase upstream activating sequence (UAS) sequence-specific DNA binding" EXACT [] is_a: GO:0000984 ! bacterial-type RNA polymerase regulatory region sequence-specific DNA binding is_a: GO:0001158 ! enhancer sequence-specific DNA binding [Term] id: GO:0001152 name: obsolete transcription factor activity, RNA polymerase III type 1 promoter sequence-specific binding, TFIIIC recruiting namespace: molecular_function def: "OBSOLETE. The function of binding to a specific DNA sequence motif in a type 1 RNA polymerase III (Pol III) promoter in order to recruit the transcription factor TFIIIC to the promoter." [GOC:txnOH, PMID:12381659] comment: This term was made obsolete in the 2018 Transcription branch revision. This represents the activity of TFIIIA only. synonym: "RNA polymerase III type 1 promoter sequence-specific DNA binding TFIIIC recruiting transcription factor activity" EXACT [] synonym: "TFIIIA activity" RELATED [] synonym: "type 1 RNA polymerase III promoter recognition" EXACT [] is_obsolete: true [Term] id: GO:0001153 name: obsolete transcription factor activity, RNA polymerase III transcription factor recruiting namespace: molecular_function def: "OBSOLETE. The function of binding to an RNA polymerase III (RNAP III) transcription factor and recruiting it to the transcription machinery complex in order to modulate transcription by RNAP III." [GOC:txnOH] comment: This term was made obsolete in the 2018 Transcription branch revision. This term was redundant with other terms. synonym: "RNA polymerase III transcription factor recruiting transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001154 name: TFIIIB-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIB complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] synonym: "TFIIIB-class transcription factor binding" EXACT [] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding [Term] id: GO:0001155 name: TFIIIA-class transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase III transcription factor of the TFIIIA class, one of the factors involved in formation of the preinitiation complex (PIC) at RNA polymerase III promoters." [GOC:txnOH, PMID:12381659] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding [Term] id: GO:0001156 name: TFIIIC-class transcription factor complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a general RNA polymerase III transcription factor belonging to the TFIIC complex, one of the factors involved in formation of the preinitiation complex (PIC) by RNA polymerase III." [GOC:txnOH, PMID:12381659] synonym: "TFIIIC-class transcription factor binding" EXACT [] is_a: GO:0001025 ! RNA polymerase III general transcription initiation factor binding [Term] id: GO:0001158 name: enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of an enhancer, a transcription regulatory region that is somewhat distal from the core promoter and which enhances transcription from that promoter." [GOC:txnOH] is_a: GO:0000976 ! transcription regulatory region sequence-specific DNA binding is_a: GO:0035326 ! enhancer binding [Term] id: GO:0001160 name: transcription termination site DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that promotes termination by RNA polymerase. The transcribed region might be described as a gene, cistron, or operon." [GOC:txnOH] is_a: GO:0044212 ! transcription regulatory region DNA binding [Term] id: GO:0001161 name: intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0044213 ! intronic transcription regulatory region DNA binding [Term] id: GO:0001162 name: RNA polymerase II intronic transcription regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II intronic DNA sequence that regulates the transcription of the transcript it is contained within." [GOC:txnOH] is_a: GO:0000977 ! RNA polymerase II regulatory region sequence-specific DNA binding is_a: GO:0001161 ! intronic transcription regulatory region sequence-specific DNA binding [Term] id: GO:0001163 name: RNA polymerase I regulatory region sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase I." [GOC:txnOH] is_a: GO:0001013 ! RNA polymerase I regulatory region DNA binding [Term] id: GO:0001164 name: RNA polymerase I CORE element sequence-specific DNA binding namespace: molecular_function alt_id: GO:0001187 def: "Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery. This site is often referred to as the CORE element. In mammalian cells, the CORE element functions in conjunction with the Upstream Control Element (UCE), while in fungi, protozoa, and plants, the CORE element functions without a UCE." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I core element sequence-specific DNA binding" EXACT [] synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor recruiting transcription factor activity" RELATED [] synonym: "RNA polymerase I core promoter sequence-specific DNA binding" EXACT [] synonym: "transcription factor activity, RNA polymerase I CORE element binding transcription factor recruiting" RELATED [] is_a: GO:0001046 ! core promoter sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001165 name: RNA polymerase I upstream control element sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I upstream element sequence-specific DNA binding" RELATED [] is_a: GO:0000987 ! proximal promoter sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001166 name: RNA polymerase I enhancer sequence-specific DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer. In mammalian cells, enhancers are distal sequences that increase the utilization of promoters, and can function in either orientation and in any location (upstream or downstream) relative to the core promoter." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] is_a: GO:0001158 ! enhancer sequence-specific DNA binding is_a: GO:0001163 ! RNA polymerase I regulatory region sequence-specific DNA binding [Term] id: GO:0001167 name: obsolete RNA polymerase I transcription factor activity, sequence-specific DNA binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase I. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:txnOH] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "sequence-specific DNA binding RNA polymerase I transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001168 name: obsolete transcription factor activity, RNA polymerase I upstream control element sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the upstream control element (UCE, or alternately referred to as the upstream element, UE), a sequence of DNA that is in cis with and relatively close to a core promoter for RNA polymerase I in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I upstream control element sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001169 name: obsolete transcription factor activity, RNA polymerase I CORE element sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with CORE element, a regulatory region composed of the transcription start site and binding sites for transcription factors of the RNA polymerase I transcription machinery in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I CORE element sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "RNA polymerase I core promoter sequence-specific DNA binding transcription factor" EXACT [] is_obsolete: true [Term] id: GO:0001170 name: obsolete transcription factor activity, RNA polymerase I enhancer sequence-specific binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a RNA polymerase I (Pol I) enhancer in order to modulate transcription by RNA polymerase I." [GOC:txnOH, PMID:12865296, PMID:14969726, PMID:8057832] comment: This term was obsoleted because it represents two separate functions. The corresponding 'binding' term should be used in combination with a transcription regulator activity child. See https://github.com/geneontology/go-ontology/issues/15787. synonym: "RNA polymerase I enhancer sequence-specific DNA binding transcription factor activity" EXACT [] is_obsolete: true [Term] id: GO:0001171 name: reverse transcription namespace: biological_process def: "A DNA synthesis process that uses RNA as the initial template for synthesis of DNA, but which also includes an RNase activity to remove the RNA strand of an RNA-DNA heteroduplex produced by the RNA-dependent synthesis step and use of the initial DNA strand as a template for DNA synthesis." [GOC:txnOH, PMID:20358252] xref: Wikipedia:Reverse_transcription is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process [Term] id: GO:0001172 name: transcription, RNA-templated namespace: biological_process def: "The cellular synthesis of RNA on a template of RNA." [GOC:txnOH] synonym: "transcription, RNA-dependent" EXACT [GOC:txnOH] is_a: GO:0097659 ! nucleic acid-templated transcription [Term] id: GO:0001173 name: DNA-templated transcriptional start site selection namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a DNA-dependent RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] synonym: "DNA-dependent transcriptional start site selection" EXACT [GOC:txnOH] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006352 ! DNA-templated transcription, initiation [Term] id: GO:0001174 name: transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH, PMID:16826228, PMID:18846104] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0006367 ! transcription initiation from RNA polymerase II promoter [Term] id: GO:0001175 name: transcriptional start site selection at RNA polymerase III promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of an RNA polymerase III promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0006384 ! transcription initiation from RNA polymerase III promoter [Term] id: GO:0001176 name: transcriptional start site selection at bacterial-type RNA polymerase promoter namespace: biological_process def: "Any process involved in the selection of the specific location within the template strand of a bacterial-type RNA polymerase promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0001173 ! DNA-templated transcriptional start site selection relationship: part_of GO:0001123 ! transcription initiation from bacterial-type RNA polymerase promoter [Term] id: GO:0001177 name: regulation of transcriptional open complex formation at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved the melting of the DNA hybrid of the core promoter region within the transcriptional closed complex of an RNA polymerase II preinitiation complex (PIC) to produce an open complex where the DNA duplex around the transcription initiation site is unwound to form the transcription bubble." [GOC:txnOH] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter relationship: regulates GO:0001113 ! transcriptional open complex formation at RNA polymerase II promoter [Term] id: GO:0001178 name: regulation of transcriptional start site selection at RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the rate, frequency or extent of a process involved in the selection of the specific location within the template strand of an RNA polymerase II promoter for hybridization of the cognate ribonucleotides and formation of first phosphodiester bond within the nascent transcript." [GOC:txnOH] is_a: GO:0060260 ! regulation of transcription initiation from RNA polymerase II promoter relationship: regulates GO:0001174 ! transcriptional start site selection at RNA polymerase II promoter [Term] id: GO:0001179 name: RNA polymerase I general transcription initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase I transcription factor, any protein required to initiate or regulate transcription by RNA polymerase I." [GOC:txnOH] synonym: "RNA polymerase I transcription factor binding" BROAD [] is_a: GO:0140296 ! general transcription initiation factor binding [Term] id: GO:0001181 name: RNA polymerase I general transcription initiation factor activity namespace: molecular_function def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase I. Factors required for RNA polymerase I transcription initiation include upstream activation factor (UAF), core factor (CF), TATA binding protein (TBP) and RRN3." [GOC:txnOH-2018, PMID:11500378, PMID:28340337, PMID:28842442] comment: Updated class label and definition, see https://github.com/geneontology/go-ontology/issues/14736 synonym: "core RNA polymerase I binding transcription factor activity" BROAD [] synonym: "general RNA polymerase I transcription factor activity" EXACT [] synonym: "RNA polymerase I transcription general initiation factor activity" EXACT [] synonym: "transcription factor activity, core RNA polymerase I binding" BROAD [] is_a: GO:0140223 ! general transcription initiation factor activity [Term] id: GO:0001182 name: promoter clearance from RNA polymerase I promoter namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001109 ! promoter clearance during DNA-templated transcription relationship: part_of GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0001183 name: transcription elongation from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I promoter for the nuclear large ribosomal RNA (rRNA) transcript by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:txnOH] is_a: GO:0006362 ! transcription elongation from RNA polymerase I promoter relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I [Term] id: GO:0001184 name: promoter clearance from RNA polymerase I promoter for nuclear large rRNA transcript namespace: biological_process def: "Any process involved in the transition from the initiation to the elongation phases of transcription by RNA polymerase I at a promoter for the nuclear large ribosomal RNA (rRNA) transcript, generally including a conformational change from the initiation conformation to the elongation conformation. Promoter clearance often involves breaking contact with transcription factors involved only in the initiation phase and making contacts with elongation specific factors." [GOC:txnOH] is_a: GO:0001182 ! promoter clearance from RNA polymerase I promoter relationship: part_of GO:0042790 ! nucleolar large rRNA transcription by RNA polymerase I [Term] id: GO:0001186 name: RNA polymerase I transcription regulator recruiting activity namespace: molecular_function def: "The function of binding to an RNA polymerase I (RNAP I) transcription regulator and recruiting it to the general transcription machinery complex in order to modulate transcription initiation." [GOC:txnOH-2018, PMID:12381659, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I transcription factor recruiting activity" EXACT [] synonym: "RNA polymerase I transcription factor recruiting transcription factor activity" EXACT [] synonym: "transcription factor activity, RNA polymerase I transcription factor recruiting" RELATED [] is_a: GO:0001134 ! transcription regulator recruiting activity is_a: GO:0001179 ! RNA polymerase I general transcription initiation factor binding [Term] id: GO:0001188 name: RNA polymerase I preinitiation complex assembly namespace: biological_process alt_id: GO:0001189 def: "The aggregation, arrangement and bonding together of proteins on promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription from an RNA polymerase I promoter." [GOC:txnOH, PMID:12381659, PMID:14969726, PMID:8057832] synonym: "RNA polymerase I transcriptional preinitiation complex assembly" EXACT [] synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nuclear large rRNA transcript" NARROW [] synonym: "RNA polymerase I transcriptional preinitiation complex assembly at the promoter for the nucleolar primary rRNA transcript" NARROW [] is_a: GO:0070897 ! transcription preinitiation complex assembly relationship: part_of GO:0006361 ! transcription initiation from RNA polymerase I promoter [Term] id: GO:0001190 name: obsolete transcriptional activator activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to increase the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription activator activity" EXACT [] synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in positive regulation of transcription" EXACT [] is_obsolete: true consider: GO:0001085 consider: GO:0001228 [Term] id: GO:0001191 name: obsolete transcriptional repressor activity, RNA polymerase II transcription factor binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with an RNA polymerase II transcription factor, which may be a single protein or a complex, in order to stop, prevent, or reduce the frequency, rate or extent of transcription from an RNA polymerase II promoter. A protein binding transcription factor may or may not also interact with the template nucleic acid (either DNA or RNA) as well." [GOC:txnOH, PMID:9811836] comment: The reason for obsoletion is that this concept is partly covered by other concepts in the ontology and usage has been inconsistent. For more details see https://github.com/geneontology/go-ontology/issues/16053 synonym: "RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription" EXACT [] synonym: "RNA polymerase II transcription factor binding transcription repressor activity" EXACT [] synonym: "RNA polymerase II transcription repressor activity" BROAD [] is_obsolete: true consider: GO:0001085 consider: GO:0001227 [Term] id: GO:0001192 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation on a DNA template." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation" EXACT [GOC:txnOH] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0001193 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase II promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from an RNA polymerase II promoter." [GOC:txnOH, PMID:14531857, PMID:16492753, PMID:17535246] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase II promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0001194 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from bacterial-type RNA polymerase promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a bacterial-type RNA polymerase promoter." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from bacterial-type RNA polymerase promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0001124 ! transcription elongation from bacterial-type RNA polymerase promoter [Term] id: GO:0001195 name: maintenance of transcriptional fidelity during DNA-templated transcription elongation from RNA polymerase III promoter namespace: biological_process def: "Suppression of the occurrence of transcriptional errors, such as substitutions and/or insertions of nucleotides that do not correctly match the template base, during the process of transcription elongation from a RNA polymerase III promoter." [GOC:txnOH] synonym: "maintenance of transcriptional fidelity during DNA-dependent transcription elongation from RNA polymerase III promoter" EXACT [GOC:txnOH] is_a: GO:0001192 ! maintenance of transcriptional fidelity during DNA-templated transcription elongation relationship: part_of GO:0006385 ! transcription elongation from RNA polymerase III promoter [Term] id: GO:0001196 name: regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:txnOH] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0007532 ! regulation of mating-type specific transcription, DNA-templated [Term] id: GO:0001197 name: positive regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "activation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "stimulation of transcription from an RNA polymerase II promoter, mating-type specific" NARROW [] synonym: "up regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "up-regulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] synonym: "upregulation of transcription from an RNA polymerase II promoter, mating-type specific" EXACT [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045895 ! positive regulation of mating-type specific transcription, DNA-templated [Term] id: GO:0001198 name: negative regulation of mating-type specific transcription from RNA polymerase II promoter namespace: biological_process def: "Any mating-type specific process that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:txnOH] synonym: "down regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "down-regulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "downregulation of RNA polymerase II transcription, mating-type specific" EXACT [] synonym: "inhibition of RNA polymerase II transcription, mating-type specific" NARROW [] is_a: GO:0001196 ! regulation of mating-type specific transcription from RNA polymerase II promoter is_a: GO:0045894 ! negative regulation of mating-type specific transcription, DNA-templated [Term] id: GO:0001207 name: histone displacement namespace: biological_process def: "The removal of histones, including histone dimers, from nucleosomes within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0001208 name: histone H2A-H2B dimer displacement namespace: biological_process def: "The removal of a H2A-H2B histone dimer from a nucleosome within chromatin." [GOC:krc, PMID:15525516, PMID:17496903, PMID:21807128] is_a: GO:0001207 ! histone displacement [Term] id: GO:0001216 name: DNA-binding transcription activator activity namespace: molecular_function alt_id: GO:0001140 alt_id: GO:0001215 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to activate or increase the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] comment: Merged terms as requested in https://github.com/geneontology/go-ontology/issues/16534\nMade term more general see https://github.com/geneontology/go-ontology/issues/16736 synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" RELATED [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional activator activity, sequence-specific DNA binding" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "transcriptional activator activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional activator activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" RELATED [] is_a: GO:0003700 ! DNA-binding transcription factor activity [Term] id: GO:0001217 name: DNA-binding transcription repressor activity namespace: molecular_function alt_id: GO:0001141 alt_id: GO:0001218 alt_id: GO:0001219 alt_id: GO:0001220 def: "Interacting selectively and non-covalently with a specific DNA sequence in order to stop, prevent, or reduce the frequency, rate or extent of transcription by a RNA polymerase." [GOC:krc] comment: Made term more general see https://github.com/geneontology/go-ontology/issues/16736 synonym: "bacterial-type DNA binding transcription repressor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, cadmium ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, copper ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcriptional repressor activity, sequence-specific DNA binding" NARROW [] synonym: "cadmium ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "copper ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "transcriptional repressor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional repressor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] is_a: GO:0003700 ! DNA-binding transcription factor activity [Term] id: GO:0001221 name: transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor, any protein involved in regulation of transcription via protein-protein interactions with transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0008134 ! transcription factor binding [Term] id: GO:0001222 name: transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription corepressor, any protein involved in negative regulation of transcription via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001223 name: transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription coactivator, any protein involved in positive regulation of transcription via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001224 name: RNA polymerase II transcription cofactor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription cofactor for RNA polymerase II, any protein involved in regulation of transcription via protein-protein interactions with RNA polymerase II transcription factors and other transcription regulatory proteins. Cofactors do not bind DNA directly, but rather mediate protein-protein interactions between regulatory transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001221 ! transcription cofactor binding [Term] id: GO:0001225 name: RNA polymerase II transcription coactivator binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription coactivator, any protein involved in positive regulation of transcription of RNA polymerase II via protein-protein interactions with transcription factors and other proteins that positively regulate transcription. Transcription coactivators do not bind DNA directly, but rather mediate protein-protein interactions between activating transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001223 ! transcription coactivator binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding [Term] id: GO:0001226 name: RNA polymerase II transcription corepressor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA polymerase II transcription corepressor, any protein involved in negative regulation of transcription by RNA polymerase II via protein-protein interactions with transcription factors and other proteins that negatively regulate transcription. Transcription corepressors do not bind DNA directly, but rather mediate protein-protein interactions between repressing transcription factors and the basal transcription machinery of RNA polymerase II." [GOC:krc] is_a: GO:0001222 ! transcription corepressor binding is_a: GO:0001224 ! RNA polymerase II transcription cofactor binding [Term] id: GO:0001227 name: DNA-binding transcription repressor activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0001078 alt_id: GO:0001206 alt_id: GO:0001210 alt_id: GO:0001214 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to repress or decrease transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 and https://github.com/geneontology/go-ontology/issues/16152\nMerge terms see https://github.com/geneontology/go-ontology/issues/16534 synonym: "distal enhancer DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription" EXACT [] synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional repressor activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in negative regulation of transcription" NARROW [] synonym: "transcriptional repressor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II distal enhancer sequence-specific binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific [Term] id: GO:0001228 name: DNA-binding transcription activator activity, RNA polymerase II-specific namespace: molecular_function alt_id: GO:0001077 alt_id: GO:0001205 alt_id: GO:0001209 alt_id: GO:0001211 alt_id: GO:0001212 alt_id: GO:0001213 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a RNA polymerase II-transcribed gene to activate or increase transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units." [GOC:txnOH-2018] comment: Merged terms, see https://github.com/geneontology/go-ontology/issues/16152 and https://github.com/geneontology/go-ontology/issues/16534; changed term label and definition https://github.com/geneontology/go-ontology/issues/16131 synonym: "copper ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "distal enhancer DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] synonym: "metal ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific" NARROW [] synonym: "RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "RNA polymerase II distal enhancer sequence-specific DNA-binding transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription" EXACT [] synonym: "RNA polymerase II transcriptional activator activity, copper ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, metal ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated core promoter proximal region sequence-specific binding" NARROW [] synonym: "RNA polymerase II transcriptional activator activity, zinc ion regulated proximal promoter sequence-specific DNA binding" NARROW [] synonym: "sequence-specific distal enhancer binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] synonym: "transcriptional activator activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding" EXACT [] synonym: "zinc ion regulated core promoter proximal region sequence-specific DNA binding RNA polymerase II transcription factor activity involved in positive regulation of transcription" NARROW [] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific is_a: GO:0001216 ! DNA-binding transcription activator activity [Term] id: GO:0001300 name: chronological cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] synonym: "chronological cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001301 name: progressive alteration of chromatin involved in cell aging namespace: biological_process def: "Any chromatin organization process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, GOC:vw, PMID:12044938] synonym: "age-dependent accumulation of genetic damage" RELATED [] synonym: "progressive alteration of chromatin during cell ageing" EXACT [] synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006325 ! chromatin organization relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0001302 name: replicative cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] synonym: "replicative cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001303 name: nucleolar fragmentation involved in replicative aging namespace: biological_process def: "A nucleolar fragmentation process that gives rise to multiple rounded structures and that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] synonym: "nucleolar fragmentation during replicative ageing" RELATED [] synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007576 ! nucleolar fragmentation relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001304 name: progressive alteration of chromatin involved in replicative cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to replicative cell aging." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001305 name: progressive alteration of chromatin involved in chronological cell aging namespace: biological_process def: "A process that results in changes in chromatin structure contributing to chronological cell aging, occurring in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001306 name: age-dependent response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] is_a: GO:0006979 ! response to oxidative stress relationship: part_of GO:0007571 ! age-dependent general metabolic decline [Term] id: GO:0001307 name: extrachromosomal circular DNA accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging [Term] id: GO:0001308 name: negative regulation of chromatin silencing involved in replicative cell aging namespace: biological_process def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] synonym: "loss of chromatin silencing involved in replicative cell aging" EXACT [] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0031936 ! negative regulation of chromatin silencing [Term] id: GO:0001309 name: obsolete age-dependent telomere shortening namespace: biological_process def: "OBSOLETE. Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] comment: This term was made obsolete because it represents a phenotype. synonym: "age-dependent telomere shortening" EXACT [] is_obsolete: true consider: GO:1903824 [Term] id: GO:0001310 name: extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001311 name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] synonym: "assembly of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging is_a: GO:0045458 ! recombination within rDNA repeats relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001312 name: replication of extrachromosomal rDNA circles involved in replicative cell aging namespace: biological_process def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001313 name: formation of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] synonym: "assembly of extrachromosomal circular DNA involved in replicative cell aging" EXACT [] synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001325 ! formation of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001314 name: replication of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001326 ! replication of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001315 name: age-dependent response to reactive oxygen species namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] synonym: "age-dependent response to active oxygen species" EXACT [] synonym: "age-dependent response to AOS" EXACT [] synonym: "age-dependent response to reactive oxidative species" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] synonym: "age-dependent response to ROI" EXACT [] synonym: "age-dependent response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001306 ! age-dependent response to oxidative stress [Term] id: GO:0001316 name: age-dependent response to reactive oxygen species involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001317 name: accumulation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging [Term] id: GO:0001318 name: formation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001319 name: inheritance of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "A protein localization process in which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0008104 ! protein localization relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001320 name: age-dependent response to reactive oxygen species involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxidative species during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging is_a: GO:0072353 ! cellular age-dependent response to reactive oxygen species [Term] id: GO:0001321 name: age-dependent general metabolic decline involved in replicative cell aging namespace: biological_process def: "A process of general metabolic decline that arises in dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001322 name: age-dependent response to oxidative stress involved in replicative cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress relationship: part_of GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging relationship: part_of GO:0034599 ! cellular response to oxidative stress [Term] id: GO:0001323 name: age-dependent general metabolic decline involved in chronological cell aging namespace: biological_process def: "A process of general metabolic decline that arises in non-dividing cells as they age, and alters cellular metabolism to cause a decline in cell function." [GOC:jh, GOC:mah] synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001324 name: age-dependent response to oxidative stress involved in chronological cell aging namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0034599 ! cellular response to oxidative stress relationship: part_of GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging [Term] id: GO:0001325 name: formation of extrachromosomal circular DNA namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] synonym: "assembly of extrachromosomal circular DNA" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0001326 name: replication of extrachromosomal circular DNA namespace: biological_process def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] is_a: GO:0006260 ! DNA replication [Term] id: GO:0001400 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0001401 name: SAM complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "mitochondrial sorting and assembly machinery complex" EXACT [] synonym: "TOB complex" EXACT [] is_a: GO:0098799 ! outer mitochondrial membrane protein complex [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0030447 ! filamentous growth [Term] id: GO:0001403 name: invasive growth in response to glucose limitation namespace: biological_process def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'entry into host ; GO:0044409', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. subset: goslim_yeast synonym: "colony morphology" RELATED [] is_a: GO:0036267 ! invasive filamentous growth [Term] id: GO:0001404 name: obsolete invasive growth namespace: biological_process def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] comment: This term was made obsolete because more appropriate terms were created. synonym: "invasive growth" EXACT [] synonym: "tissue invasion" EXACT [] is_obsolete: true consider: GO:0044409 [Term] id: GO:0001405 name: PAM complex, Tim23 associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the TIM23 mitochondrial import inner membrane translocase complex (GO:0005744); ATPase motor activity to drive import of proteins into the mitochondrial matrix." [GOC:mcc, GOC:vw, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] synonym: "presequence translocase-associated import motor" EXACT [] is_a: GO:0005759 ! mitochondrial matrix is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005744 ! TIM23 mitochondrial import inner membrane translocase complex [Term] id: GO:0001406 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity [Term] id: GO:0001407 name: glycerophosphodiester transmembrane transport namespace: biological_process def: "The process in which a glycerophosphodiester is transported across a membrane. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0001408 name: guanine nucleotide transport namespace: biological_process def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mcc] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0001409 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of a membrane to the other." [GOC:mcc] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity [Term] id: GO:0001410 name: chlamydospore formation namespace: biological_process alt_id: GO:0055027 def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] synonym: "chlamydospore development" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth is_a: GO:0051286 ! cell tip [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development [Term] id: GO:0001502 name: cartilage condensation namespace: biological_process def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] is_a: GO:0098743 ! cell aggregation relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, PMID:17572649] comment: Note that this term does not have a 'developmental process' parent because ossification isn't necessarily developmental, can also occur as part of bone remodeling. Instead use 'ossification involved in bone maturation ; GO:0043931'. synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters." [ISBN:0123668387] subset: goslim_synapse synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0098657 ! import into cell [Term] id: GO:0001505 name: regulation of neurotransmitter levels namespace: biological_process def: "Any process that modulates levels of neurotransmitter." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0001506 name: obsolete neurotransmitter biosynthetic process and storage namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] comment: This term was made obsolete because it is an amalgamation of its two children. synonym: "neurotransmitter anabolism and storage" EXACT [] synonym: "neurotransmitter biosynthetic process and storage" EXACT [] synonym: "neurotransmitter formation and storage" EXACT [] synonym: "neurotransmitter synthesis and storage" EXACT [] is_obsolete: true consider: GO:0042136 consider: GO:0042137 [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: action potential namespace: biological_process def: "A process in which membrane potential cycles through a depolarizing spike, triggered in response to depolarization above some threshold, followed by repolarization. This cycle is driven by the flow of ions through various voltage gated channels with different thresholds and ion specificities." [GOC:dph, GOC:go_curators, GOC:tb, ISBN:978-0-07-139011-8] comment: Action potentials typically propagate across excitable membranes. This class covers both action potentials that propagate and those that fail to do so. is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001509 name: obsolete legumain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] comment: This term was made obsolete because it represents a gene product. synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "legumain activity" EXACT [] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0001511 name: obsolete fibrillin namespace: molecular_function def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "fibrillin" EXACT [] is_obsolete: true consider: GO:0001527 consider: GO:0005509 [Term] id: GO:0001512 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN xref: reactome:R-HSA-8936519 "NQO2:FAD dimer reduces quinones to hydroquinones" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0001514 name: selenocysteine incorporation namespace: biological_process def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] xref: RESID:AA0022 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0001516 name: prostaglandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] synonym: "prostaglandin anabolism" EXACT [] synonym: "prostaglandin biosynthesis" EXACT [] synonym: "prostaglandin formation" EXACT [] synonym: "prostaglandin synthesis" EXACT [] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0046457 ! prostanoid biosynthetic process [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] subset: goslim_chembl synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: reactome:R-HSA-2046222 "CHST2,5,6 transfer SO4(2-) to GlcNAc residues on keratan-PG to form KSPG" xref: reactome:R-HSA-6786012 "CHST4 transfers SO4(2-) from PAPS to Core 2 mucins" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0001519 name: peptide amidation namespace: biological_process def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] is_a: GO:0031179 ! peptide modification [Term] id: GO:0001520 name: outer dense fiber namespace: cellular_component def: "A supramolecular fiber found in the flagella of mammalian sperm that surrounds the nine microtubule doublets. These dense fibers are stiff and noncontractile. In human, they consist of about 10 major and at least 15 minor proteins, where all major proteins are ODF1, ODF2 or ODF2-related proteins." [GOC:cilia, GOC:krc, ISBN:0824072820, PMID:10381817, PMID:21586547, PMID:25361759] synonym: "outer dense fibre" EXACT [] is_a: GO:0044441 ! ciliary part is_a: GO:0097223 ! sperm part is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0036126 ! sperm flagellum [Term] id: GO:0001522 name: pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] synonym: "pseudouridylation" EXACT [] xref: Wikipedia:Pseudouridine xref: Wikipedia:Pseudouridylation is_a: GO:0009451 ! RNA modification [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732] synonym: "retinoid metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001524 name: obsolete globin namespace: molecular_function def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "globin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001526 name: obsolete proteoglycan sulfate transfer namespace: biological_process def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] comment: This term was made obsolete because it represents a group of molecular functions. synonym: "proteoglycan sulfate transfer" EXACT [] synonym: "proteoglycan sulphate transfer" EXACT [] is_obsolete: true consider: GO:0006029 consider: GO:0006790 consider: GO:0050698 [Term] id: GO:0001527 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [PMID:27026396] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] is_a: GO:0044420 ! extracellular matrix component is_a: GO:0099512 ! supramolecular fiber [Term] id: GO:0001528 name: obsolete elastin namespace: molecular_function def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "elastin" EXACT [] is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001529 name: obsolete elastin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "elastin" EXACT [] is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001530 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] is_a: GO:0008289 ! lipid binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0001531 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0001532 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-21 receptor activity" EXACT [GOC:mah] synonym: "IL-21R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0001533 name: cornified envelope namespace: cellular_component def: "A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes)." [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] is_a: GO:0005886 ! plasma membrane [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: GO:0032991 ! protein-containing complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0001535 name: radial spoke head namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:cilia, GOC:hjd, GOC:krc] synonym: "radial spokehead" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001536 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001537 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: reactome:R-HSA-2022063 "CHST14 transfers SO4(2-) to GalNAc in dermatan or DS" xref: reactome:R-HSA-6786034 "CHST8 transfers SO4(2-) from PAPS to glyco-Lutropin" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001539 name: cilium or flagellum-dependent cell motility namespace: biological_process def: "Cell motility due to movement of eukaryotic cilia or bacterial-type flagella or archaeal-type flagella." [GOC:cilia, GOC:hjd, GOC:krc] comment: Note that we deem eukaryotic cilia and microtubule-based flagella to be equivalent, while the bacterial- and archaeal-type flagella have a different structure. The former are microtubule-based structures that lash back and forth and are present only in eukaryotes, while the latter achieve motility by rotation. Bacterial- and archaeal-type flagella are superficially similar but have a different molecular composition and fine structure. These three structures never co-exist in the same organism. Therefore, GO:0001539 'cilium or flagellum-dependent cell motility' is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term. Direct annotations to GO:0001539 'cilium or flagellum-dependent cell motility' may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "ciliary or bacterial-type flagellar motility" RELATED [] synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001540 name: amyloid-beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor." [GOC:hjd] subset: goslim_chembl synonym: "beta-amyloid binding" EXACT [] is_a: GO:0042277 ! peptide binding [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] synonym: "follicular phase" RELATED [] is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001542 name: ovulation from ovarian follicle namespace: biological_process def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030728 ! ovulation relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001543 name: ovarian follicle rupture namespace: biological_process def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001542 ! ovulation from ovarian follicle [Term] id: GO:0001544 name: initiation of primordial ovarian follicle growth namespace: biological_process def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0048162 ! multi-layer follicle stage [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001548 name: follicular fluid formation in ovarian follicle antrum namespace: biological_process def: "The menstrual cycle process that results in the formation of one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process in which a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001550 name: ovarian cumulus expansion namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0040007 ! growth relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001551 name: ovarian follicle endowment namespace: biological_process def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "A periodic process in which immature ovarian follicles degenerate and are subsequently re-absorbed." [GOC:mtg_apoptosis, http://ovary.stanford.edu, PMID:18638134] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001554 name: luteolysis namespace: biological_process def: "The lysis or structural demise of the corpus luteum. During normal luteolysis, two closely related events occur. First, there is loss of the capacity to synthesize and secrete progesterone (functional luteolysis) followed by loss of the cells that comprise the corpus luteum (structural luteolysis). Preventing luteolysis is crucial to maintain pregnancy." [http://ovary.stanford.edu, PMID:10617764] xref: Wikipedia:Luteolysis is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The developmental growth process in which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001557 name: obsolete metabolic process resulting in cell growth namespace: biological_process def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. synonym: "metabolic process resulting in cell growth" EXACT [] is_obsolete: true consider: GO:0008152 consider: GO:0016049 [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate, extent or direction of cell growth." [GOC:go_curators] is_a: GO:0040008 ! regulation of growth is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001559 name: regulation of cell growth by detection of nuclear:cytoplasmic ratio namespace: biological_process def: "Any process in which the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio is_a: GO:0061387 ! regulation of extent of cell growth [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process in which external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001561 name: fatty acid alpha-oxidation namespace: biological_process def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] xref: MetaCyc:PWY-2501 is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0001562 name: response to protozoan namespace: biological_process alt_id: GO:0042833 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] synonym: "resistance to pathogenic protozoa" RELATED [] synonym: "response to protozoa" EXACT [] synonym: "response to protozoon" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0001563 name: detection of protozoan namespace: biological_process def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] synonym: "detection of protozoa" EXACT [] synonym: "detection of protozoon" EXACT [] synonym: "perception of protozoa" RELATED [] is_a: GO:0001562 ! response to protozoan is_a: GO:0098543 ! detection of other organism [Term] id: GO:0001564 name: obsolete resistance to pathogenic protozoa namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic protozoa" EXACT [] is_obsolete: true replaced_by: GO:0001562 [Term] id: GO:0001565 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:10506570] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0001566 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester and transmitting the signal by a mechanism independent of kinase activity." [PMID:10506570] is_a: GO:0001565 ! phorbol ester receptor activity [Term] id: GO:0001567 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + cholesterol + O(2) = 25-hydroxycholesterol + A + H(2)O." [EC:1.14.99.38, RHEA:21104] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: KEGG:R07218 xref: MetaCyc:1.14.99.38-RXN xref: RHEA:21104 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd, UBERON:0001981] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001569 name: branching involved in blood vessel morphogenesis namespace: biological_process def: "The process of coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "patterning of blood vessels" BROAD [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001571 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor (FGF) and transmitting the signal from one side of the membrane to the other by a mechanism independent of tyrosine kinase activity." [GOC:signaling, PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0001572 name: lactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732, ISBN:0471586501] synonym: "lactosylceramide anabolism" EXACT [] synonym: "lactosylceramide biosynthesis" EXACT [] synonym: "lactosylceramide formation" EXACT [] synonym: "lactosylceramide synthesis" EXACT [] is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046478 ! lactosylceramide metabolic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001573 name: ganglioside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] synonym: "ganglioside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001574 name: ganglioside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732] synonym: "ganglioside anabolism" EXACT [] synonym: "ganglioside biosynthesis" EXACT [] synonym: "ganglioside formation" EXACT [] synonym: "ganglioside synthesis" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0001575 name: globoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732] synonym: "globoside metabolism" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001576 name: globoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1->3)-Gal-alpha-(1->4)-Glc(I)." [ISBN:0198506732] synonym: "globoside anabolism" EXACT [] synonym: "globoside biosynthesis" EXACT [] synonym: "globoside formation" EXACT [] synonym: "globoside synthesis" EXACT [] is_a: GO:0001575 ! globoside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001577 name: obsolete galectin namespace: molecular_function def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] comment: This term was made obsolete because it refers to a class of gene products. synonym: "galectin" EXACT [] synonym: "S-type lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0016936 [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001579 name: medium-chain fatty acid transport namespace: biological_process def: "The directed movement of medium-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12." [CHEBI:59554, GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0001580 name: detection of chemical stimulus involved in sensory perception of bitter taste namespace: biological_process def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "bitter taste detection" EXACT [] synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of bitter taste" EXACT [] synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] synonym: "sensory transduction of bitter taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050913 ! sensory perception of bitter taste [Term] id: GO:0001581 name: detection of chemical stimulus involved in sensory perception of sour taste namespace: biological_process def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory detection of sour taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory transduction of sour taste" EXACT [] synonym: "sour taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050915 ! sensory perception of sour taste [Term] id: GO:0001582 name: detection of chemical stimulus involved in sensory perception of sweet taste namespace: biological_process def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory detection of sweet taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory transduction of sweet taste" EXACT [] synonym: "sweet taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050916 ! sensory perception of sweet taste [Term] id: GO:0001583 name: detection of chemical stimulus involved in sensory perception of salty taste namespace: biological_process def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] synonym: "salty taste detection" EXACT [] synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory detection of salty taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory transduction of salty taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050914 ! sensory perception of salty taste [Term] id: GO:0001584 name: obsolete rhodopsin-like receptor activity namespace: molecular_function alt_id: GO:0001620 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] synonym: "rhodopsin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001586 name: Gi/o-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gi/o subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gi/o subunit subsequently inhibits adenylate cyclase and results in a decrease in cyclic AMP (cAMP) levels." [GOC:mah, PMID:18571247] synonym: "5-HT1 receptor activity" EXACT [GOC:bf] synonym: "serotonin receptor activity, coupled via Gi/o" EXACT [GOC:bf] is_a: GO:0004993 ! G protein-coupled serotonin receptor activity [Term] id: GO:0001587 name: Gq/11-coupled serotonin receptor activity namespace: molecular_function def: "Combining with serotonin and transmitting the signal across the membrane by activation of the Gq/11 subunit of an associated cytoplasmic heterotrimeric G protein complex. The Gq/11 subunit subsequently activates phospholipase C and results in an increase in inositol triphosphate (IP3) levels." [GOC:bf, GOC:mah, PMID:18571247, PMID:18703043] synonym: "5-HT2 receptor activity" BROAD [GOC:bf] synonym: "serotonin receptor activity, coupled via Gq/11" EXACT [GOC:bf] is_a: GO:0004993 ! G protein-coupled serotonin receptor activity [Term] id: GO:0001588 name: dopamine neurotransmitter receptor activity, coupled via Gs namespace: molecular_function alt_id: GO:0001589 alt_id: GO:0001590 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2252, IUPHAR_RECEPTOR:2260] synonym: "dopamine D1 receptor activity" NARROW [GOC:bf] synonym: "dopamine D5 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001591 name: dopamine neurotransmitter receptor activity, coupled via Gi/Go namespace: molecular_function alt_id: GO:0001592 alt_id: GO:0001593 alt_id: GO:0001670 def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033, IUPHAR_RECEPTOR:2254, IUPHAR_RECEPTOR:2256, IUPHAR_RECEPTOR:2258] synonym: "dopamine D2 receptor activity" NARROW [GOC:bf] synonym: "dopamine D3 receptor activity" NARROW [GOC:bf] synonym: "dopamine D4 receptor activity" NARROW [GOC:bf] is_a: GO:0004952 ! dopamine neurotransmitter receptor activity [Term] id: GO:0001594 name: trace-amine receptor activity namespace: molecular_function def: "Combining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals." [GOC:mah, PMID:19325074] is_a: GO:0008227 ! G protein-coupled amine receptor activity [Term] id: GO:0001595 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001596 name: angiotensin type I receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gq-mediated activation of phospholipase C followed by phosphoinositide hydrolysis and Ca2+ signaling, and may act via additional signaling mechanisms." [GOC:mah, PMID:10977869] synonym: "PLC-activating angiotensin receptor activity" EXACT [GOC:bf] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0001597 name: obsolete apelin-like receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because the function it represents does not exist. synonym: "apelin-like receptor" EXACT [] synonym: "APJ-like receptor" EXACT [] is_obsolete: true consider: GO:0031704 [Term] id: GO:0001598 name: obsolete chemokine receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "chemokine receptor-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001601 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001602 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001603 name: obsolete vasopressin-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] synonym: "vasopressin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001604 name: urotensin II receptor activity namespace: molecular_function def: "Combining with urotensin II to initiate a change in cell activity." [GOC:mah, PMID:15102493] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001605 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] is_a: GO:0097642 ! calcitonin family receptor activity [Term] id: GO:0001606 name: obsolete GPR37/endothelin B-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "GPR37/endothelin B-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001607 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0001608 name: G protein-coupled nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, IUPHAR_GPCR:1294] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] synonym: "nucleotide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001609 name: G protein-coupled adenosine receptor activity namespace: molecular_function alt_id: GO:0001610 alt_id: GO:0001611 alt_id: GO:0001612 alt_id: GO:0001613 alt_id: GO:0008501 def: "Combining with adenosine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "adenosine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "P1 receptor" EXACT [PMID:9755289] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "P2 receptor" RELATED [PMID:9755289] is_a: GO:0016502 ! nucleotide receptor activity is_a: GO:0035586 ! purinergic receptor activity [Term] id: GO:0001615 name: obsolete thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "thyrotropin releasing hormone and secretagogue-like receptors activity" EXACT [] is_obsolete: true [Term] id: GO:0001616 name: growth hormone secretagogue receptor activity namespace: molecular_function def: "Combining with ghrelin to initiate a change in cell activity." [GOC:mah, PMID:17983853] synonym: "ghrelin receptor activity" EXACT [GOC:mah, PMID:17983853] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001617 name: obsolete growth hormone secretagogue-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "growth hormone secretagogue-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001618 name: virus receptor activity namespace: molecular_function def: "Combining with a virus component and mediating entry of the virus into the cell." [GOC:bf, GOC:dph, PMID:7621403, UniProtKB-KW:KW-1183] subset: goslim_chembl synonym: "viral receptor activity" EXACT [] is_a: GO:0140272 ! exogenous protein binding [Term] id: GO:0001619 name: obsolete lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] synonym: "lysosphingolipid and lysophosphatidic acid receptor activity" EXACT [] is_obsolete: true consider: GO:0038036 consider: GO:0070915 [Term] id: GO:0001621 name: ADP receptor activity namespace: molecular_function def: "Combining with ADP and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:11196645] synonym: "K101 receptor" NARROW [] synonym: "platelet ADP receptor activity" NARROW [GOC:mah] is_a: GO:0045028 ! G protein-coupled purinergic nucleotide receptor activity [Term] id: GO:0001626 name: nociceptin receptor activity namespace: molecular_function def: "Combining with the peptide nociceptin, and transmitting the signal across the membrane by activating an associated G-protein." [GOC:bf, GOC:mah, PMID:18670432] synonym: "nociceptin/orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "OFQ receptor activity" EXACT [PR:000012940] synonym: "ORPH receptor" EXACT [] synonym: "orphanin-FQ receptor activity" EXACT [GOC:bf] synonym: "X-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0001627 name: obsolete leucine-rich G-protein receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "leucine-rich G-protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001628 name: obsolete gastropyloric receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the gastropyloric receptor is a type of neuron. synonym: "gastropyloric receptor activity" EXACT [] synonym: "GPR receptor" EXACT [] is_obsolete: true [Term] id: GO:0001629 name: obsolete G-protein receptor 45-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "G-protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001630 name: obsolete GP40-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "GP40-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001631 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] synonym: "CysLT receptor" EXACT [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001632 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732] synonym: "BLT receptor" NARROW [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001633 name: obsolete secretin-like receptor activity namespace: molecular_function alt_id: GO:0001638 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] synonym: "secretin-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001634 name: pituitary adenylate cyclase-activating polypeptide receptor activity namespace: molecular_function alt_id: GO:0016522 def: "A G protein-coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001635 name: calcitonin gene-related peptide receptor activity namespace: molecular_function def: "Combining with a calcitonin gene-related polypeptide (CGRP) to initiate a change in cell activity." [GOC:mah, PMID:12037140] synonym: "calcitonin gene-related polypeptide receptor activity" EXACT [] synonym: "CGRP receptor" EXACT [] xref: Wikipedia:CALCRL is_a: GO:0097642 ! calcitonin family receptor activity [Term] id: GO:0001636 name: obsolete corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001637 name: G protein-coupled chemoattractant receptor activity namespace: molecular_function def: "Combining with a chemoattractant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:mah] synonym: "G protein chemoattractant receptor activity" EXACT [] synonym: "G-protein chemoattractant receptor activity" EXACT [GOC:bf] synonym: "G-protein coupled chemoattractant receptor activity" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001639 name: PLC activating G protein-coupled glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] synonym: "PLC activating G-protein coupled glutamate receptor activity" EXACT [] synonym: "PLC activating metabotropic glutamate receptor activity" EXACT [GOC:bf] is_a: GO:0098988 ! G protein-coupled glutamate receptor activity [Term] id: GO:0001640 name: adenylate cyclase inhibiting G protein-coupled glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex to inhibit downstream adenylate cyclase activity." [GOC:bf, GOC:dph] synonym: "adenylate cyclase inhibiting metabotropic glutamate receptor activity" RELATED [GOC:bf] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] is_a: GO:0098988 ! G protein-coupled glutamate receptor activity [Term] id: GO:0001641 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [Term] id: GO:0001642 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G protein-coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] is_a: GO:0001640 ! adenylate cyclase inhibiting G protein-coupled glutamate receptor activity [Term] id: GO:0001646 name: cAMP receptor activity namespace: molecular_function alt_id: GO:0001644 def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] is_a: GO:0001614 ! purinergic nucleotide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0001647 name: G protein-coupled cytokinin receptor activity namespace: molecular_function def: "Combining with cytokinin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "cytokinin receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein coupled cytokinin receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0001648 name: proteinase activated receptor activity namespace: molecular_function def: "A G protein-coupled peptide receptor activity that is initiated by cleavage of the N terminus of the receptor by a serine protease, resulting in the generation of a new tethered ligand that interacts with the receptor." [GOC:mah, PMID:11356985] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone." [CL:0000062, GO_REF:0000034, GOC:jid] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001650 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001651 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] synonym: "pars fibrosa" BROAD [NIF_Subcellular:sao1841764412] xref: NIF_Subcellular:sao1841764412 is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001652 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] synonym: "pars granulosa" BROAD [NIF_Subcellular:sao1217793903] xref: NIF_Subcellular:sao1217793903 is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0150063 ! visual system development [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0072164 ! mesonephric tubule development [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of an epithelial tube relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process in which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001660 name: fever generation namespace: biological_process def: "The heat generation process that results in a rise in body temperature above the normal, often as a response to infection." [GOC:dph, GOC:jl] synonym: "pyrexia" BROAD [] xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001662 name: behavioral fear response namespace: biological_process def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] synonym: "behavioural fear response" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0042596 ! fear response [Term] id: GO:0001664 name: G protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein coupled receptor binding" EXACT [GOC:bf] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: reactome:R-HSA-500717 "Activation of GRIK3 homomer" is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0001665 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-(1->3)-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-[(2->6)-alpha-N-acetylneuraminyl]-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN xref: reactome:R-HSA-4084980 "ST6GALNAC1-6 transfer Neu5Ac to terminal GalNAc (alpha-2,6 link)" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to intermittent hypoxia" NARROW [] synonym: "response to lowered oxygen tension" EXACT [] synonym: "response to sustained hypoxia" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0036293 ! response to decreased oxygen levels [Term] id: GO:0001667 name: ameboidal-type cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] comment: Note that this term refers to a mode of migration rather than to any particular cell type. synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732] synonym: "acrosomal granule" EXACT [GOC:sart] synonym: "acrosome" EXACT [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! secretory granule is_a: GO:0097223 ! sperm part [Term] id: GO:0001671 name: ATPase activator activity namespace: molecular_function def: "Binds to and increases the ATP hydrolysis activity of an ATPase." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] xref: reactome:R-HSA-5251955 "HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm" xref: reactome:R-HSA-5251959 "HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0001672 name: regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:1902275 ! regulation of chromatin organization relationship: regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component alt_id: GO:0043081 def: "The nucleus of a male germ cell, a reproductive cell in males." [CL:0000015, GOC:hjd, GOC:mtg_sensu] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [CL:0000021, GOC:hjd] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033363 ! secretory granule organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ajp] synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0001680 name: tRNA 3'-terminal CCA addition namespace: biological_process def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition." [EC:2.7.7.72, GOC:go_curators] synonym: "-C-C-A pyrophosphorylase activity" RELATED [EC:2.7.7.72] synonym: "ATP(CTP)-tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CCA-adding enzyme activity" EXACT [EC:2.7.7.72] synonym: "CCA-adding enzyme, tRNA adenylyltransferase, tRNA cytidylyltransferase, tRNA CCA-pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "CTP(ATP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "CTP:tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase activity" EXACT [EC:2.7.7.72] synonym: "ribonucleic cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer ribonucleate nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic acid nucleotidyl transferase activity" BROAD [EC:2.7.7.72] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase activity" RELATED [EC:2.7.7.72] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "transfer RNA adenylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "transfer-RNA nucleotidyltransferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA adenylyl(cytidylyl)transferase activity" BROAD [EC:2.7.7.72] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.72] synonym: "tRNA cytidylyltransferase activity" NARROW [EC:2.7.7.72] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.72] xref: KEGG:R09382 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0042780 ! tRNA 3'-end processing [Term] id: GO:0001681 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0001682 name: tRNA 5'-leader removal namespace: biological_process def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] synonym: "tRNA 5' leader removal" EXACT [] is_a: GO:0099116 ! tRNA 5'-end processing [Term] id: GO:0001683 name: obsolete axonemal dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein heavy chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001684 name: obsolete axonemal dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein intermediate chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001685 name: obsolete axonemal dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein intermediate light chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001686 name: obsolete axonemal dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "axonemal dynein light chain" EXACT [] is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001687 name: obsolete cytoplasmic dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein heavy chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001688 name: obsolete cytoplasmic dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein intermediate chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001689 name: obsolete cytoplasmic dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein intermediate light chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001690 name: obsolete cytoplasmic dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "cytoplasmic dynein light chain" EXACT [] is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001691 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] is_a: GO:0019212 ! phosphatase inhibitor activity [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process alt_id: GO:0001693 def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001697 name: histamine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001698 name: gastrin-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001699 name: acetylcholine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion relationship: part_of GO:1905145 ! cellular response to acetylcholine [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process alt_id: GO:0010003 alt_id: GO:0048276 def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" NARROW [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001708 name: cell fate specification namespace: biological_process def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001709 name: cell fate determination namespace: biological_process def: "A process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] xref: Wikipedia:Cell_fate_determination is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001710 name: mesodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] synonym: "mesoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0048333 ! mesodermal cell differentiation [Term] id: GO:0001711 name: endodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] synonym: "endoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0035987 ! endodermal cell differentiation [Term] id: GO:0001712 name: ectodermal cell fate commitment namespace: biological_process def: "The cell differentiation process that results in commitment of a cell to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in formation of primary germ layer relationship: part_of GO:0001705 ! ectoderm formation relationship: part_of GO:0010668 ! ectodermal cell differentiation [Term] id: GO:0001713 name: ectodermal cell fate determination namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001714 name: endodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "endoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0001715 name: ectodermal cell fate specification namespace: biological_process def: "The cell fate determination process that results in a cell becoming becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "ectoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001716 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.2] synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN xref: reactome:R-HSA-2160492 "IL4I1:FAD oxidises L-Phe to kPPV" xref: RHEA:13781 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0001717 name: conversion of seryl-tRNAsec to selenocys-tRNAsec namespace: biological_process def: "The modification process that results in the conversion of serine, carried by a specialized tRNA(ser) (which can read a UGA anticodon), to selenocysteine." [ISBN:155581073X] is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001720 name: conversion of lysyl-tRNA to pyrrolysyl-tRNA namespace: biological_process def: "The modification process that results in the conversion of lysine, carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon), to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001721 name: obsolete intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "IFAP" EXACT [] synonym: "intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001722 name: obsolete type I intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type I intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001723 name: obsolete type II intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type II intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001724 name: obsolete type III intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "type III intermediate filament associated protein" EXACT [] is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0001725 name: stress fiber namespace: cellular_component def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] synonym: "actin cable" RELATED [GOC:mah] synonym: "stress fibre" EXACT [] is_a: GO:0042641 ! actomyosin is_a: GO:0097517 ! contractile actin filament bundle [Term] id: GO:0001726 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0001727 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] is_a: GO:0016301 ! kinase activity [Term] id: GO:0001729 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide-1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: MetaCyc:CERAMIDE-KINASE-RXN xref: reactome:R-HSA-1638845 "CERK phosphorylates CERA to form C1P" xref: RHEA:17929 is_a: GO:0001727 ! lipid kinase activity [Term] id: GO:0001730 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. This reaction requires the binding of double-stranded RNA." [ISBN:0198506732] synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] xref: EC:2.7.7.84 xref: MetaCyc:RXN-10798 xref: MetaCyc:RXN-13648 xref: reactome:R-HSA-8983680 "OAS1 produces oligoadenylates" xref: reactome:R-HSA-8985091 "OAS3 produces oligoadenylates" xref: reactome:R-HSA-8985104 "OAS2 produces oligoadenylates" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0001731 name: formation of translation preinitiation complex namespace: biological_process def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. synonym: "formation of translation pre-initiation complex" EXACT [] synonym: "translation preinitiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0001732 name: formation of cytoplasmic translation initiation complex namespace: biological_process def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] synonym: "cytoplasmic translation initiation complex assembly" EXACT [] synonym: "formation of translation initiation complex" BROAD [] synonym: "translation initiation complex assembly" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0001733 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN xref: RHEA:20613 is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity [Term] id: GO:0001734 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R is a purine, and H is C, A, or U." [GOC:hjd] xref: reactome:R-HSA-72095 "Internal Methylation of mRNA" is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0001735 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H2O = a prenal + L-cysteine + H2O2." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: MetaCyc:1.8.3.5-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001737 name: establishment of imaginal disc-derived wing hair orientation namespace: biological_process def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] synonym: "establishment of wing hair orientation" EXACT [] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The morphogenetic process in which the anatomical structures of a polarized epithelium are generated and organized. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "Chromatin that is part of a sex chromosome." [GOC:dos, ISBN:0198506732] is_a: GO:0005720 ! nuclear heterochromatin relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0001740 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, NIF_Subcellular:sao1571698684] xref: NIF_Subcellular:sao1571698684 xref: Wikipedia:Barr_body is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000805 ! X chromosome [Term] id: GO:0001741 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] is_a: GO:0000803 ! sex chromosome [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001743 name: optic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048598 ! embryonic morphogenesis [Term] id: GO:0001744 name: optic lobe placode formation namespace: biological_process alt_id: GO:0007457 def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] is_a: GO:0060788 ! ectodermal placode formation [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the compound eye are generated and organized. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0001746 name: Bolwig's organ morphogenesis namespace: biological_process def: "The morphogenetic process in which the anatomical structures of the larval eye in Drosophila are generated and organized. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0055034 ! Bolwig's organ development [Term] id: GO:0001748 name: optic lobe placode development namespace: biological_process alt_id: GO:0048049 def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] synonym: "optic placode development" BROAD [] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0001750 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [GOC:cilia, ISBN:0824072820] is_a: GO:0044441 ! ciliary part is_a: GO:0097458 ! neuron part relationship: part_of GO:0097733 ! photoreceptor cell cilium [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0001752 name: compound eye photoreceptor fate commitment namespace: biological_process alt_id: GO:0007459 def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0001753 name: obsolete adult eye photoreceptor development (sensu Drosophila) namespace: biological_process def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. synonym: "adult eye photoreceptor development (sensu Drosophila)" EXACT [] is_obsolete: true consider: GO:0042051 [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0014032 ! neural crest cell development [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001757 name: somite specification namespace: biological_process def: "The process in which individual somites establish identity during embryogenesis." [GOC:dph] is_a: GO:0007379 ! segment specification is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0001758 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN xref: reactome:R-HSA-5362522 "ALDHs oxidise atRAL to atRA" xref: reactome:R-HSA-5696101 "ALDH8A1 oxidises 9cRAL to 9cRA" xref: RHEA:16177 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0001759 name: organ induction namespace: biological_process def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] synonym: "induction of an organ" EXACT [GOC:curators] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:0031128 ! developmental induction is_a: GO:0110110 ! positive regulation of animal organ morphogenesis relationship: positively_regulates GO:0010092 ! specification of animal organ identity [Term] id: GO:0001760 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-carboxymuconate 6-semialdehyde + H(+) = 2-aminomuconate 6-semialdehyde + CO(2)." [EC:4.1.1.45, RHEA:16557] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "ACMSD activity" EXACT [PMID:17288562] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: KEGG:R04323 xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN xref: RHEA:16557 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0001761 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:hjd] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process in which the anatomical structures of branches are generated and organized. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [CL:0000540, GOC:go_curators] synonym: "neuron chemotaxis" EXACT [GOC:curators] synonym: "neuron guidance" RELATED [GOC:curators] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0001765 name: membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] synonym: "lipid raft assembly" EXACT [GOC:mah] synonym: "lipid raft formation" RELATED [] synonym: "membrane raft formation" RELATED [GOC:mah] is_a: GO:0031579 ! membrane raft organization is_a: GO:0071709 ! membrane assembly [Term] id: GO:0001766 name: membrane raft polarization namespace: biological_process def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] synonym: "lipid raft polarization" EXACT [] is_a: GO:0031580 ! membrane raft distribution [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042110 ! T cell activation [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042113 ! B cell activation [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0030101 ! natural killer cell activation [Term] id: GO:0001771 name: immunological synapse formation namespace: biological_process def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] synonym: "formation of immunological synapse" EXACT [GOC:curators] is_a: GO:0009988 ! cell-cell recognition relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001772 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: Wikipedia:Immunological_synapse is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0002269 ! leukocyte activation involved in inflammatory response is_a: GO:0042116 ! macrophage activation is_a: GO:0061900 ! glial cell activation [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0001778 name: plasma membrane repair namespace: biological_process def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development" RELATED [GOC:add] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, GOC:pr, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0001781 name: neutrophil apoptotic process namespace: biological_process def: "Any apoptotic process in a neutrophil, any of the immature or mature forms of a granular leukocyte that in its mature form has a nucleus with three to five lobes connected by slender threads of chromatin, and cytoplasm containing fine inconspicuous granules and stainable by neutral dyes." [CL:0000775, GOC:add, GOC:mtg_apoptosis, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil apoptosis" NARROW [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0006925 ! inflammatory cell apoptotic process is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process relationship: part_of GO:0001780 ! neutrophil homeostasis [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149, PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0001783 name: B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell, a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [CL:0000236, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell apoptosis" NARROW [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptotic process [Term] id: GO:0001784 name: phosphotyrosine residue binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584] synonym: "phosphotyrosine binding" RELATED [] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0001785 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0001786 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732, PMID:12000961] is_a: GO:0005543 ! phospholipid binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0001788 name: antibody-dependent cellular cytotoxicity namespace: biological_process def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [GOC:pr, ISBN:0781735149, PMID:11677095, PMID:9581795] synonym: "ADCC" EXACT [] synonym: "antibody dependent cell death" EXACT [] synonym: "antibody dependent cell killing" EXACT [] synonym: "antibody-dependent cell death" EXACT [] synonym: "antibody-dependent cell killing" EXACT [] synonym: "type VI hypersensitivity" EXACT [] xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity is_a: GO:0001794 ! type IIa hypersensitivity is_a: GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001790 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001791 name: IgM binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001792 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001793 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001794 name: type IIa hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149] comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001795 name: type IIb hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. synonym: "type V hypersensitivity" EXACT [] is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001796 name: regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001797 name: negative regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIa hypersensitivity" EXACT [] synonym: "down-regulation of type IIa hypersensitivity" EXACT [] synonym: "downregulation of type IIa hypersensitivity" EXACT [] synonym: "inhibition of type IIa hypersensitivity" NARROW [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001798 name: positive regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIa hypersensitivity" NARROW [] synonym: "stimulation of type IIa hypersensitivity" NARROW [] synonym: "up regulation of type IIa hypersensitivity" EXACT [] synonym: "up-regulation of type IIa hypersensitivity" EXACT [] synonym: "upregulation of type IIa hypersensitivity" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001799 name: regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001800 name: negative regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IIb hypersensitivity" EXACT [] synonym: "down-regulation of type IIb hypersensitivity" EXACT [] synonym: "downregulation of type IIb hypersensitivity" EXACT [] synonym: "inhibition of type IIb hypersensitivity" NARROW [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001801 name: positive regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IIb hypersensitivity" NARROW [] synonym: "stimulation of type IIb hypersensitivity" NARROW [] synonym: "up regulation of type IIb hypersensitivity" EXACT [] synonym: "up-regulation of type IIb hypersensitivity" EXACT [] synonym: "upregulation of type IIb hypersensitivity" EXACT [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001802 name: type III hypersensitivity namespace: biological_process def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149] comment: Note that the Arthus reaction is an example of type III hypersensitivity. xref: Wikipedia:Type_III_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0001803 name: regulation of type III hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001804 name: negative regulation of type III hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type III hypersensitivity" EXACT [] synonym: "down-regulation of type III hypersensitivity" EXACT [] synonym: "downregulation of type III hypersensitivity" EXACT [] synonym: "inhibition of type III hypersensitivity" NARROW [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001805 name: positive regulation of type III hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type III hypersensitivity" NARROW [] synonym: "stimulation of type III hypersensitivity" NARROW [] synonym: "up regulation of type III hypersensitivity" EXACT [] synonym: "up-regulation of type III hypersensitivity" EXACT [] synonym: "upregulation of type III hypersensitivity" EXACT [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001806 name: type IV hypersensitivity namespace: biological_process alt_id: GO:0016069 def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149] synonym: "delayed hypersensitivity response" EXACT [] synonym: "delayed-type hypersensitivity" EXACT [] xref: Wikipedia:Type_IV_hypersensitivity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002524 ! hypersensitivity [Term] id: GO:0001807 name: regulation of type IV hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002883 ! regulation of hypersensitivity relationship: regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001808 name: negative regulation of type IV hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type IV hypersensitivity" EXACT [] synonym: "down-regulation of type IV hypersensitivity" EXACT [] synonym: "downregulation of type IV hypersensitivity" EXACT [] synonym: "inhibition of type IV hypersensitivity" NARROW [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002884 ! negative regulation of hypersensitivity relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001809 name: positive regulation of type IV hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type IV hypersensitivity" NARROW [] synonym: "stimulation of type IV hypersensitivity" NARROW [] synonym: "up regulation of type IV hypersensitivity" EXACT [] synonym: "up-regulation of type IV hypersensitivity" EXACT [] synonym: "upregulation of type IV hypersensitivity" EXACT [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002885 ! positive regulation of hypersensitivity relationship: positively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001810 name: regulation of type I hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001811 name: negative regulation of type I hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "down regulation of type I hypersensitivity" EXACT [] synonym: "down-regulation of type I hypersensitivity" EXACT [] synonym: "downregulation of type I hypersensitivity" EXACT [] synonym: "inhibition of type I hypersensitivity" NARROW [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001812 name: positive regulation of type I hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149] synonym: "activation of type I hypersensitivity" NARROW [] synonym: "stimulation of type I hypersensitivity" NARROW [] synonym: "up regulation of type I hypersensitivity" EXACT [] synonym: "up-regulation of type I hypersensitivity" EXACT [] synonym: "upregulation of type I hypersensitivity" EXACT [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001813 name: regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of antibody dependent cell death" EXACT [] synonym: "regulation of antibody dependent cell killing" EXACT [] synonym: "regulation of antibody-dependent cell death" EXACT [] synonym: "regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001814 name: negative regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "negative regulation of antibody dependent cell death" EXACT [] synonym: "negative regulation of antibody dependent cell killing" EXACT [] synonym: "negative regulation of antibody-dependent cell death" EXACT [] synonym: "negative regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001815 name: positive regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "positive regulation of antibody dependent cell death" EXACT [] synonym: "positive regulation of antibody dependent cell killing" EXACT [] synonym: "positive regulation of antibody-dependent cell death" EXACT [] synonym: "positive regulation of antibody-dependent cell killing" EXACT [] synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. subset: goslim_pir synonym: "interferon production" NARROW [GOC:add, GOC:mah] synonym: "interleukin production" NARROW [GOC:add, GOC:mah, http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001816 ! cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine production" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149] synonym: "activation of cytokine production" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732, ISBN:0781735149] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] synonym: "serotonin release" RELATED [GOC:tb] is_a: GO:0006837 ! serotonin transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or tissue. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732, ISBN:0781735149] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544] synonym: "nephrogenesis" RELATED [GOC:rph] xref: Wikipedia:Kidney_development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544, PMID:10535314] synonym: "Wolffian body development" EXACT [GOC:dph] is_a: GO:0001822 ! kidney development [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001701 ! in utero embryonic development [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001827 name: inner cell mass cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001828 name: inner cell mass cellular morphogenesis namespace: biological_process def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001830 name: trophectodermal cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell fate commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001835 name: blastocyst hatching namespace: biological_process def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. is_a: GO:0035188 ! hatching relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001836 name: release of cytochrome c from mitochondria namespace: biological_process def: "The process that results in the movement of cytochrome c from the mitochondrial intermembrane space into the cytosol, which is part of the apoptotic signaling pathway and leads to caspase activation." [GOC:add, GOC:mah, GOC:mtg_apoptosis, ISBN:0721639976, PMID:12925707, PMID:9560217] comment: The release of cytochrome c from mitochondria is a central event in the signaling phase of the apoptotic process, and it is often used by researchers to monitor this type of cell death. Any event that induces apoptosis will at some point induce the release of cytochrome c from mitochondria. Therefore, this term should only be used to annotate gene products that are directly involved in this process. An example is Drp1 (DNM1L, UniProt symbol O00429) in PMID:20850011. is_a: GO:0008637 ! apoptotic mitochondrial changes relationship: part_of GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] synonym: "mesenchymal cell differentiation from epithelial cell" EXACT [GOC:BHF, GOC:dph, GOC:rl] is_a: GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the neural plate are generated and organized. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process in which the neural fold is formed. The edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] synonym: "neural groove formation" RELATED [GOC:dph] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001844 name: protein insertion into mitochondrial membrane involved in apoptotic signaling pathway namespace: biological_process def: "The process in which a protein is incorporated into a mitochondrial membrane as the initial phase of the mitochondrial membrane permeabilization that takes place in the apoptotic signaling pathway." [GOC:add, GOC:mtg_apoptosis, PMID:12952892] comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" NARROW [GOC:dph, GOC:tb] synonym: "protein insertion into mitochondrial membrane involved in induction of apoptosis" NARROW [] synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" NARROW [] is_a: GO:0051204 ! protein insertion into mitochondrial membrane relationship: part_of GO:0097345 ! mitochondrial outer membrane permeabilization [Term] id: GO:0001845 name: phagolysosome assembly namespace: biological_process def: "The process that results in the fusion of a phagosome, a vesicle formed by phagocytosis, with a lysosome." [GOC:add, ISBN:0781735149] synonym: "late phagosome biosynthesis" RELATED [] synonym: "late phagosome formation" RELATED [] synonym: "phagolysosome formation" RELATED [GOC:mah] is_a: GO:0007040 ! lysosome organization is_a: GO:0016050 ! vesicle organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0006909 ! phagocytosis relationship: part_of GO:0090382 ! phagosome maturation [Term] id: GO:0001846 name: opsonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. is_a: GO:0005515 ! protein binding [Term] id: GO:0001847 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0001848 name: complement binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0005515 ! protein binding [Term] id: GO:0001849 name: complement component C1q binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001850 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001851 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001852 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001853 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001854 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001855 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001856 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149] is_a: GO:0001848 ! complement binding [Term] id: GO:0001857 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q component of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001858 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001859 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001860 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001861 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001862 name: collectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001863 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001847 ! opsonin receptor activity [Term] id: GO:0001864 name: pentraxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T cell development" RELATED [GOC:add] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149, PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0001867 name: complement activation, lectin pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. synonym: "complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0001868 name: regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149] synonym: "regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001869 name: negative regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "down regulation of complement activation, lectin pathway" EXACT [] synonym: "down-regulation of complement activation, lectin pathway" EXACT [] synonym: "downregulation of complement activation, lectin pathway" EXACT [] synonym: "inhibition of complement activation, lectin pathway" NARROW [] synonym: "negative regulation of complement cascade, lectin pathway" EXACT [GOC:add] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001870 name: positive regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149] synonym: "activation of complement activation, lectin pathway" NARROW [] synonym: "positive regulation of complement cascade, lectin pathway" EXACT [GOC:add] synonym: "stimulation of complement activation, lectin pathway" NARROW [] synonym: "up regulation of complement activation, lectin pathway" EXACT [] synonym: "up-regulation of complement activation, lectin pathway" EXACT [] synonym: "upregulation of complement activation, lectin pathway" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001871 name: obsolete pattern binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: This term was obsoleted because it was an unnecessary grouping term. synonym: "pattern recognition activity" BROAD [] is_obsolete: true [Term] id: GO:0001872 name: (1->3)-beta-D-glucan binding namespace: molecular_function alt_id: GO:0080087 def: "Interacting selectively and non-covalently with (1->3)-beta-D-glucans." [PMID:14707091] synonym: "1,3-beta-D-glucan binding" EXACT [] synonym: "callose binding" NARROW [] synonym: "zymosan binding" NARROW [GOC:tb] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001873 name: polysaccharide receptor activity namespace: molecular_function def: "Combining with a polysaccharide and transmitting the signal to initiate a change in cell activity. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, PMID:14707091] is_a: GO:0008329 ! signaling pattern recognition receptor activity [Term] id: GO:0001874 name: (1->3)-beta-D-glucan receptor activity namespace: molecular_function def: "Combining with (1->3)-beta-D-glucans to initiate a change in cell activity." [PMID:14707091] synonym: "(1,3)-beta-D-glucan receptor activity" EXACT [] synonym: "1,3-beta-D-glucan receptor activity" EXACT [] synonym: "beta-1,3-D-glucan receptor activity" EXACT [] synonym: "zymosan receptor activity" NARROW [GOC:tb] is_a: GO:0001873 ! polysaccharide receptor activity [Term] id: GO:0001875 name: lipopolysaccharide receptor activity namespace: molecular_function def: "Combining with a lipopolysaccharide and transmitting the signal across the cell membrane to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] synonym: "endotoxin receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] is_a: GO:0008329 ! signaling pattern recognition receptor activity [Term] id: GO:0001876 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] is_a: GO:0034235 ! GPI anchor binding [Term] id: GO:0001877 name: lipoarabinomannan receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan and transmitting the signal to initiate a change in cell activity." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] is_a: GO:0008329 ! signaling pattern recognition receptor activity [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] comment: defined as response to Saccharomycotina (true yeasts). This excludes fission yeast. is_a: GO:0009620 ! response to fungus [Term] id: GO:0001879 name: detection of yeast namespace: biological_process def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] is_a: GO:0001878 ! response to yeast is_a: GO:0016046 ! detection of fungus [Term] id: GO:0001880 name: Mullerian duct regression namespace: biological_process def: "The process in which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0001881 name: receptor recycling namespace: biological_process def: "The process that results in the return of receptor molecules to an active state and an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:0097367 ! carbohydrate derivative binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001884 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0001885 ! endothelial cell development [Term] id: GO:0001887 name: selenium compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds that contain selenium, such as selenocysteine." [PMID:12730456] synonym: "selenium compound metabolism" EXACT [] synonym: "selenium metabolic process" EXACT [] synonym: "selenium metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0001888 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X] is_a: GO:0048732 ! gland development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0001891 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048568 ! embryonic organ development relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development is_a: GO:0060135 ! maternal process involved in female pregnancy relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001895 name: retina homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "A programmed cell death process observed in bacteria and filamentous fungi and leading to spontaneous death by lysis. Examples are lysis of the mother cell during sporulation of Bacillus subtilis and self-degradation of fungal cells in Aspergillus nidulans. Autolysis is also involved in bacterial biofilm formation." [GOC:add, GOC:jh2, GOC:mtg_apoptosis, PMID:10974124, PMID:19286987, PMID:26811896] xref: Wikipedia:Autolysis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0001897 name: cytolysis by symbiont of host cells namespace: biological_process def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] synonym: "cytolysis by organism of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0051801 ! cytolysis in other organism involved in symbiotic interaction [Term] id: GO:0001898 name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0051802 ! regulation of cytolysis in other organism involved in symbiotic interaction relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001899 name: negative regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051803 ! negative regulation of cytolysis in other organism involved in symbiotic interaction relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001900 name: positive regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process in which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] synonym: "activation by symbiont of cytolysis of host cells" NARROW [] synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051804 ! positive regulation of cytolysis in other organism involved in symbiotic interaction relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001905 name: activation of membrane attack complex namespace: biological_process def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149] synonym: "activation of MAC" EXACT [] synonym: "activation of TCC" NARROW [] synonym: "activation of terminal complement complex" NARROW [GOC:add] synonym: "activation of the terminal complement cascade" NARROW [] synonym: "MAC assembly" EXACT [GOC:rl] synonym: "MAC formation" EXACT [GOC:rl] synonym: "membrane attack complex assembly" EXACT [GOC:rl] synonym: "membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0006956 ! complement activation [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] is_a: GO:0044004 ! disruption by symbiont of host cell is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:11911826] comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001906 ! cell killing [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0031341 ! regulation of cell killing relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0031342 ! negative regulation of cell killing relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149, PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0031343 ! positive regulation of cell killing relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, GOC:pr, ISBN:0781735149, PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001917 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir is_a: GO:0097458 ! neuron part [Term] id: GO:0001918 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765] is_a: GO:0005515 ! protein binding [Term] id: GO:0001919 name: regulation of receptor recycling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] is_a: GO:0023051 ! regulation of signaling is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0001881 ! receptor recycling [Term] id: GO:0001920 name: negative regulation of receptor recycling namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] synonym: "down regulation of receptor recycling" EXACT [] synonym: "down-regulation of receptor recycling" EXACT [] synonym: "downregulation of receptor recycling" EXACT [] synonym: "inhibition of receptor recycling" NARROW [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0031324 ! negative regulation of cellular metabolic process relationship: negatively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001921 name: positive regulation of receptor recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] synonym: "activation of receptor recycling" NARROW [] synonym: "stimulation of receptor recycling" NARROW [] synonym: "up regulation of receptor recycling" EXACT [] synonym: "up-regulation of receptor recycling" EXACT [] synonym: "upregulation of receptor recycling" EXACT [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0031325 ! positive regulation of cellular metabolic process relationship: positively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process in which a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] synonym: "B-1 B cell development" RELATED [GOC:add] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of B-1 B cell development" RELATED [GOC:add] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B cell development" RELATED [GOC:add] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B cell development" RELATED [GOC:add] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001927 name: exocyst assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, PMID:9700152, Wikipedia:Exocyst] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0140029 ! exocytic process relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis [Term] id: GO:0001928 name: regulation of exocyst assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0106020 ! regulation of vesicle docking relationship: regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001929 name: negative regulation of exocyst assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of exocyst assembly." [GOC:hjd] synonym: "down regulation of exocyst assembly" EXACT [] synonym: "down-regulation of exocyst assembly" EXACT [] synonym: "downregulation of exocyst assembly" EXACT [] synonym: "inhibition of exocyst assembly" NARROW [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0045920 ! negative regulation of exocytosis is_a: GO:0106021 ! negative regulation of vesicle docking relationship: negatively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001930 name: positive regulation of exocyst assembly namespace: biological_process def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] synonym: "activation of exocyst assembly" NARROW [] synonym: "stimulation of exocyst assembly" NARROW [] synonym: "up regulation of exocyst assembly" EXACT [] synonym: "up-regulation of exocyst assembly" EXACT [] synonym: "upregulation of exocyst assembly" EXACT [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0045921 ! positive regulation of exocytosis is_a: GO:0106022 ! positive regulation of vesicle docking relationship: positively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001931 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031254 ! cell trailing edge [Term] id: GO:0001932 name: regulation of protein phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] synonym: "regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation relationship: regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001933 name: negative regulation of protein phosphorylation namespace: biological_process def: "Any process that stops, prevents or reduces the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] synonym: "negative regulation of protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation relationship: negatively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001934 name: positive regulation of protein phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "positive regulation of protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation relationship: positively_regulates GO:0006468 ! protein phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149] is_a: GO:0050673 ! epithelial cell proliferation [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001939 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "A process which results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph, GOC:pr] synonym: "post-synaptic membrane organization" EXACT [] synonym: "postsynaptic membrane organisation" EXACT [GOC:curators] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0099173 ! postsynapse organization [Term] id: GO:0001942 name: hair follicle development namespace: biological_process alt_id: GO:0001943 def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, UBERON:0002073] is_a: GO:0022405 ! hair cycle process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0098773 ! skin epidermis development [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure. The vasculature is an interconnected tubular multi-tissue structure that contains fluid that is actively transported around the organism." [GOC:dph, UBERON:0002409] synonym: "vascular system development" RELATED [GOC:curators] is_a: GO:0048731 ! system development relationship: part_of GO:0072358 ! cardiovascular system development [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a lymph vessel over time, from its formation to the mature structure." [GOC:dph, UBERON:0001473] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0036303 ! lymph vessel morphogenesis [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The tube morphogenesis process in which the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration. Heart looping begins with dextral-looping and ends when the main regional divisions of the mature heart and primordium of the great arterial trunks become established preceeding septation." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0001950 name: obsolete plasma membrane enriched fraction namespace: cellular_component def: "OBSOLETE: The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "plasma membrane enriched fraction" EXACT [] synonym: "PME fraction" RELATED [GOC:mah] is_obsolete: true consider: GO:0005886 [Term] id: GO:0001951 name: intestinal D-glucose absorption namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0106001 ! intestinal hexose absorption [Term] id: GO:0001952 name: regulation of cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] is_a: GO:0010810 ! regulation of cell-substrate adhesion relationship: regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001953 name: negative regulation of cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] synonym: "down regulation of cell-matrix adhesion" EXACT [] synonym: "down-regulation of cell-matrix adhesion" EXACT [] synonym: "downregulation of cell-matrix adhesion" EXACT [] synonym: "inhibition of cell-matrix adhesion" NARROW [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010812 ! negative regulation of cell-substrate adhesion relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001954 name: positive regulation of cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] synonym: "activation of cell-matrix adhesion" NARROW [] synonym: "stimulation of cell-matrix adhesion" NARROW [] synonym: "up regulation of cell-matrix adhesion" EXACT [] synonym: "up-regulation of cell-matrix adhesion" EXACT [] synonym: "upregulation of cell-matrix adhesion" EXACT [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010811 ! positive regulation of cell-substrate adhesion relationship: positively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0050806 ! positive regulation of synaptic transmission is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "Direct ossification that occurs within mesenchyme or an accumulation of relatively unspecialized cells." [ISBN:0878932437] comment: An instance of intramembranous ossification may also be classified as metaplastic; the former classifies based on tissue type location, and the latter based on mechanism/cell division. synonym: "dermal ossification" NARROW [GO_REF:0000034] synonym: "intramembranous bone ossification" RELATED [GOC:cjm] xref: Wikipedia:Intramembranous_ossification is_a: GO:0036072 ! direct ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "Replacement ossification wherein bone tissue replaces cartilage." [GO_REF:0000034, ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0036075 ! replacement ossification relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0060759 ! regulation of response to cytokine stimulus relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0060761 ! negative regulation of response to cytokine stimulus relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0060760 ! positive regulation of response to cytokine stimulus relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001962 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-(1->3) linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] xref: EC:2.4.1 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The vesicular release of dopamine. from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, GOC:dph] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0001964 name: startle response namespace: biological_process def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] xref: Wikipedia:Startle_reaction is_a: GO:0009605 ! response to external stimulus is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0001965 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0001966 name: thigmotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] synonym: "stereotaxis" EXACT [] synonym: "taxis in response to mechanical stimulus" BROAD [] synonym: "taxis in response to touch stimulus" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0001967 name: suckling behavior namespace: biological_process def: "Specific behavior of a newborn or infant mammal that results in the derivation of nourishment from the breast." [GOC:dph, GOC:pr] synonym: "nursing behavior" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0001969 name: regulation of activation of membrane attack complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "regulation of activation of MAC" EXACT [GOC:mah] synonym: "regulation of activation of TCC" NARROW [GOC:mah] synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "regulation of MAC assembly" EXACT [GOC:rl] synonym: "regulation of MAC formation" EXACT [GOC:rl] synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0030449 ! regulation of complement activation relationship: regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001970 name: positive regulation of activation of membrane attack complex namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "activation of activation of membrane attack complex" NARROW [] synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] synonym: "positive regulation of MAC formation" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] synonym: "stimulation of activation of membrane attack complex" NARROW [] synonym: "up regulation of activation of membrane attack complex" EXACT [] synonym: "up-regulation of activation of membrane attack complex" EXACT [] synonym: "upregulation of activation of membrane attack complex" EXACT [] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045917 ! positive regulation of complement activation relationship: positively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001971 name: negative regulation of activation of membrane attack complex namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "down regulation of activation of membrane attack complex" EXACT [] synonym: "down-regulation of activation of membrane attack complex" EXACT [] synonym: "downregulation of activation of membrane attack complex" EXACT [] synonym: "inhibition of activation of membrane attack complex" NARROW [] synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] synonym: "negative regulation of MAC formation" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045916 ! negative regulation of complement activation relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001972 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] is_a: GO:0005501 ! retinoid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0001973 name: adenosine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a receptor binding to extracellular adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:dph] synonym: "adenosine receptor signaling pathway, G-protein coupled" EXACT [PMID:9755289] synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] synonym: "P1 receptor signaling pathway" EXACT [PMID:9755289] is_a: GO:0035588 ! G protein-coupled purinergic receptor signaling pathway [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] is_a: GO:0048771 ! tissue remodeling [Term] id: GO:0001975 name: response to amphetamine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [CHEBI:2679, GOC:dph, GOC:ef] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0009636 ! response to toxic substance is_a: GO:0014075 ! response to amine is_a: GO:0097366 ! response to bronchodilator [Term] id: GO:0001976 name: neurological system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0050877 ! nervous system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels [Term] id: GO:0001978 name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "baroreceptor feedback control of blood pressure" RELATED [] synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X] synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0001979 name: regulation of systemic arterial blood pressure by chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "chemoreceptor control of blood pressure" RELATED [] synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001980 name: regulation of systemic arterial blood pressure by ischemic conditions namespace: biological_process def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "CNS ischemic response" RELATED [ISBN:0721643949] synonym: "ischemic control of blood pressure" RELATED [] synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001981 name: baroreceptor detection of arterial stretch namespace: biological_process def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0001982 name: baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0001983 name: baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951, ISBN:0721643949] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0001984 name: artery vasodilation involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure" EXACT [] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001985 name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949] synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001986 name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0045822 ! negative regulation of heart contraction relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001987 name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001988 name: positive regulation of heart rate involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001989 name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949] synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0001993 name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949] synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0001994 name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949] synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001995 name: norepinephrine-epinephrine catabolic process in blood stream namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] is_a: GO:0042419 ! epinephrine catabolic process relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0001996 name: positive regulation of heart rate by epinephrine-norepinephrine namespace: biological_process def: "The process in which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001997 name: positive regulation of the force of heart contraction by epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] synonym: "increased inotropy by epinephrine-norepinephrine" RELATED [] synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001998 name: angiotensin-mediated vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, GOC:pr, ISBN:0721643949] synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] synonym: "angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0002034 ! regulation of blood vessel diameter by renin-angiotensin [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002000 name: detection of renal blood flow namespace: biological_process def: "The process in which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949] is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002002 name: regulation of angiotensin levels in blood namespace: biological_process def: "The process that modulates the level of any of the various angiotensinogen proteolytic products in the blood. This occurs by the proteolytic cleavage of angiotensinogen, and its proteolytic products, to create a variety of active peptide hormones, such as angiotensin I and angiotensin II, as well as through the removal of these peptides from the circulation." [GOC:rl, PMID:21951628, Wikipedia:Angiotensin] comment: Updated definition as discussed inhttps://github.com/geneontology/go-ontology/issues/15424 synonym: "control of angiotensin levels in blood" RELATED [] synonym: "control of blood angiotensin level" RELATED [] synonym: "regulation of blood angiotensin level" EXACT [] is_a: GO:0010817 ! regulation of hormone levels relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002003 name: angiotensin maturation namespace: biological_process alt_id: GO:0002005 def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of angiotensinogen into mature angiotensin in the blood." [ISBN:0721643949] synonym: "angiotensin catabolic process in blood" NARROW [] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002004 name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure namespace: biological_process def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949] synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0030103 ! vasopressin secretion relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002006 name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002007 name: detection of hypoxic conditions in blood by chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0002008 name: excitation of vasomotor center by chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process in which the anatomical structures of epithelia are generated and organized. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732] synonym: "epithelium morphogenesis" EXACT [] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002010 name: excitation of vasomotor center by baroreceptor signaling namespace: biological_process def: "The process in which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process in which the anatomical structures of an epithelial sheet are generated and organized. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002012 name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002013 name: detection of carbon dioxide by vasomotor center namespace: biological_process def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002014 name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure namespace: biological_process def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002015 name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback namespace: biological_process def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "atrial control of blood pressure" RELATED [] synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] synonym: "atrial reflex" RELATED [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0002016 name: regulation of blood volume by renin-angiotensin namespace: biological_process def: "The process in which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "renin-angiotensin control of body fluid levels" RELATED [] synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0002017 name: regulation of blood volume by renal aldosterone namespace: biological_process def: "The process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949] synonym: "aldosterone mediated control of body fluids" RELATED [] synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002018 name: renin-angiotensin regulation of aldosterone production namespace: biological_process def: "The process in which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949] synonym: "renin-angiotensin control of aldosterone production" RELATED [] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure is_a: GO:2000858 ! regulation of aldosterone secretion relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002019 name: regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949] synonym: "angiotensin mediated control of renal output" RELATED [] synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002020 name: protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd] xref: reactome:R-HSA-1297354 "Acrosin Cleavage" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0002021 name: response to dietary excess namespace: biological_process def: "The physiological process in which dietary excess is sensed by the central nervous system, resulting in a reduction in food intake and increased energy expenditure." [GOC:pg, GOC:pr, PMID:12161655] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0002022 name: detection of dietary excess namespace: biological_process def: "The neurological process in which the brain senses excessive caloric intake." [PMID:12161655] is_a: GO:0050877 ! nervous system process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002023 name: reduction of food intake in response to dietary excess namespace: biological_process def: "An eating behavior process whereby detection of a dietary excess results in a decrease in intake of nutrients." [GOC:pg, GOC:pr, PMID:12161655, PMID:12840200] is_a: GO:0042755 ! eating behavior relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002024 name: diet induced thermogenesis namespace: biological_process def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] is_a: GO:1990845 ! adaptive thermogenesis relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002025 name: norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] synonym: "vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0002026 name: regulation of the force of heart contraction namespace: biological_process def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] synonym: "heart inotropy" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002029 name: desensitization of G protein-coupled receptor signaling pathway namespace: biological_process def: "The process that stops, prevents, or reduces the frequency, rate or extent of G protein-coupled receptor signaling pathway after prolonged stimulation with an agonist of the pathway." [PMID:8396717] synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0022401 ! negative adaptation of signaling pathway is_a: GO:0045744 ! negative regulation of G protein-coupled receptor signaling pathway [Term] id: GO:0002030 name: inhibitory G protein-coupled receptor phosphorylation namespace: biological_process def: "The process that inhibits the signaling function of a G protein-coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] synonym: "inhibitory G-protein coupled receptor phosphorylation" EXACT [] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway [Term] id: GO:0002031 name: G protein-coupled receptor internalization namespace: biological_process def: "The process that results in the uptake of a G protein-coupled receptor into an endocytic vesicle." [PMID:8396717] synonym: "G-protein coupled receptor internalization" EXACT [] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway [Term] id: GO:0002032 name: desensitization of G protein-coupled receptor signaling pathway by arrestin namespace: biological_process def: "The process that inhibits the signaling function of a G protein-coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "desensitization of G-protein coupled receptor protein signaling pathway by arrestin" EXACT [] is_a: GO:0002029 ! desensitization of G protein-coupled receptor signaling pathway is_a: GO:0032091 ! negative regulation of protein binding [Term] id: GO:0002033 name: angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the diameter of a blood vessel via the renin-angiotensin system." [GOC:pr, ISBN:0323031951, PMID:10425188] synonym: "vasodilation by angiotensin involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002034 ! regulation of blood vessel diameter by renin-angiotensin [Term] id: GO:0002034 name: regulation of blood vessel diameter by renin-angiotensin namespace: biological_process def: "The process in which the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:pr, GOC:tb] synonym: "regulation of blood vessel size by renin-angiotensin" BROAD [] synonym: "renin-angiotensin regulation of blood vessel size" BROAD [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin is_a: GO:0097746 ! regulation of blood vessel diameter [Term] id: GO:0002035 name: brain renin-angiotensin system namespace: biological_process def: "The process in which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002036 name: regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900920 def: "Any process that modulates the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] synonym: "regulation of L-glutamate transport" BROAD [] synonym: "regulation of L-glutamate uptake" EXACT [GOC:TermGenie] is_a: GO:0010958 ! regulation of amino acid import across plasma membrane is_a: GO:0051580 ! regulation of neurotransmitter uptake is_a: GO:2001023 ! regulation of response to drug relationship: regulates GO:0098712 ! L-glutamate import across plasma membrane [Term] id: GO:0002037 name: negative regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900921 def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "down regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down regulation of L-glutamate transport" BROAD [] synonym: "down regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "down-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "down-regulation of L-glutamate transport" BROAD [] synonym: "down-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "downregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "downregulation of L-glutamate transport" BROAD [] synonym: "downregulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "inhibition of L-glutamate import" NARROW [GOC:TermGenie] synonym: "inhibition of L-glutamate transport" NARROW [] synonym: "inhibition of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "negative regulation of L-glutamate import" BROAD [] synonym: "negative regulation of L-glutamate transport" BROAD [] synonym: "negative regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "regulation of L-glutamate import" BROAD [] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0051581 ! negative regulation of neurotransmitter uptake is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903960 ! negative regulation of anion transmembrane transport is_a: GO:2001024 ! negative regulation of response to drug relationship: negatively_regulates GO:0098712 ! L-glutamate import across plasma membrane [Term] id: GO:0002038 name: positive regulation of L-glutamate import across plasma membrane namespace: biological_process alt_id: GO:1900922 def: "Any process that activates or increases the frequency, rate or extent of L-glutamate import into a cell." [GOC:TermGenie] synonym: "activation of L-glutamate import" NARROW [GOC:TermGenie] synonym: "activation of L-glutamate transport" NARROW [] synonym: "activation of L-glutamate uptake" NARROW [GOC:TermGenie] synonym: "positive regulation of L-glutamate import" BROAD [] synonym: "positive regulation of L-glutamate transport" BROAD [] synonym: "positive regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up regulation of L-glutamate transport" BROAD [] synonym: "up regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "up-regulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate uptake" RELATED [GOC:TermGenie] synonym: "upregulation of L-glutamate import" EXACT [GOC:TermGenie] synonym: "upregulation of L-glutamate transport" BROAD [] synonym: "upregulation of L-glutamate uptake" RELATED [GOC:TermGenie] is_a: GO:0002036 ! regulation of L-glutamate import across plasma membrane is_a: GO:0051582 ! positive regulation of neurotransmitter uptake is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903961 ! positive regulation of anion transmembrane transport is_a: GO:2001025 ! positive regulation of response to drug relationship: positively_regulates GO:0098712 ! L-glutamate import across plasma membrane [Term] id: GO:0002039 name: p53 binding namespace: molecular_function def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002040 name: sprouting angiogenesis namespace: biological_process def: "The extension of new blood vessels from existing vessels into avascular tissues, this process includes the specialization of endothelial cells into leading tip and stalk cells, proliferation and migration of the endothelial cells and cell adhesion resulting in angiogenic sprout fusion or lumen formation." [PMID:16391003, PMID:23031691] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002041 name: intussusceptive angiogenesis namespace: biological_process def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002042 name: cell migration involved in sprouting angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002043 name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001935 ! endothelial cell proliferation relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002044 name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002045 name: regulation of cell adhesion involved in intussusceptive angiogenesis namespace: biological_process def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002046 name: opsin binding namespace: molecular_function alt_id: GO:0016030 def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] synonym: "metarhodopsin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0002047 name: phenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] synonym: "acridizine biosynthesis" RELATED [] synonym: "acridizine biosynthetic process" RELATED [] synonym: "azophenylene biosynthesis" RELATED [] synonym: "azophenylene biosynthetic process" RELATED [] synonym: "dibenzo-p-diazine biosynthesis" RELATED [] synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] synonym: "dibenzopyrazine biosynthesis" RELATED [] synonym: "dibenzopyrazine biosynthetic process" RELATED [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0002048 name: pyoverdine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] synonym: "pyoverdine metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0002049 name: pyoverdine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0002050 name: pyoverdine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0002051 name: osteoblast fate commitment namespace: biological_process def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0050769 ! positive regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation is_a: GO:2000648 ! positive regulation of stem cell proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002054 name: nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir is_a: GO:0036094 ! small molecule binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0002055 name: adenine binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002056 name: cytosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cytosine." [GOC:hjd, GOC:vw] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002057 name: guanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanine." [GOC:hjd] is_a: GO:0002060 ! purine nucleobase binding [Term] id: GO:0002058 name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding is_a: GO:0008144 ! drug binding [Term] id: GO:0002059 name: thymine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thymine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine nucleobase binding [Term] id: GO:0002060 name: purine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleobase, an organic nitrogenous base with a purine skeleton." [CHEBI:26386, GOC:hjd] synonym: "purine base binding" EXACT [GOC:go_curators] synonym: "purine binding" RELATED [GOC:curators] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002061 name: pyrimidine nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleobase, an organic nitrogenous base with a pyrimidine skeleton." [CHEBI:26432, GOC:hjd] synonym: "1,3-diazine binding" NARROW [] synonym: "pyrimidine base binding" EXACT [GOC:go_curators] synonym: "pyrimidine binding" RELATED [GOC:curators] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0002062 ! chondrocyte differentiation [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0002067 ! glandular epithelial cell differentiation [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0002068 ! glandular epithelial cell development [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development is_a: GO:0060538 ! skeletal muscle organ development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002075 name: somitomeric trunk muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] is_a: GO:0060538 ! skeletal muscle organ development [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002077 name: acrosome matrix dispersal namespace: biological_process def: "The proteolytic digestion of components in the acrosomal matrix that occurs as part of the acrosome reaction. The process can occur either in the cumulus oophorous facilitating the penetration of it by the sperm, or at the zona pellucida allowing the sperm to reach the plasma membrane of the egg where the inner acrosomal membrane of the sperm can interact with the egg plasma membrane." [GOC:dph, PMID:3886029] is_a: GO:0022414 ! reproductive process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002078 name: membrane fusion involved in acrosome reaction namespace: biological_process def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0061025 ! membrane fusion relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002079 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0097223 ! sperm part is_a: GO:0098589 ! membrane region relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane is_a: GO:0097223 ! sperm part relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0002081 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0097223 ! sperm part is_a: GO:0098589 ! membrane region relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002082 name: regulation of oxidative phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:1903578 ! regulation of ATP metabolic process relationship: regulates GO:0006119 ! oxidative phosphorylation [Term] id: GO:0002083 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-decaprenyl diphosphate + 4-hydroxybenzoate = 3-decaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:RXN-9230] xref: EC:2.5.1.39 xref: MetaCyc:RXN-9230 xref: reactome:R-HSA-2162192 "PHB and all-E-10PrP2 are combined into DHB by COQ2" is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0002084 name: protein depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] is_a: GO:0035601 ! protein deacylation is_a: GO:0042159 ! lipoprotein catabolic process is_a: GO:0098734 ! macromolecule depalmitoylation [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process in which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002086 name: diaphragm contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] is_a: GO:0003011 ! involuntary skeletal muscle contraction is_a: GO:0003016 ! respiratory system process [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by neurological system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! nervous system process [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process in which the anatomical structures of the lens are generated and organized. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0002090 name: regulation of receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0031623 ! receptor internalization [Term] id: GO:0002091 name: negative regulation of receptor internalization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "down regulation of receptor internalization" EXACT [] synonym: "down-regulation of receptor internalization" EXACT [] synonym: "downregulation of receptor internalization" EXACT [] synonym: "inhibition of receptor internalization" NARROW [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis relationship: negatively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002092 name: positive regulation of receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "activation of receptor internalization" NARROW [] synonym: "stimulation of receptor internalization" NARROW [] synonym: "up regulation of receptor internalization" EXACT [] synonym: "up-regulation of receptor internalization" EXACT [] synonym: "upregulation of receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis relationship: positively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060117 ! auditory receptor cell development [Term] id: GO:0002094 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0002095 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005901 ! caveola [Term] id: GO:0002096 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process in which the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process in which a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002099 name: tRNA wobble guanine modification namespace: biological_process def: "The process in which a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002100 name: tRNA wobble adenosine to inosine editing namespace: biological_process def: "The process in which an adenosine in position 34 of a tRNA is post-transcriptionally converted to inosine." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification is_a: GO:0006382 ! adenosine to inosine editing [Term] id: GO:0002101 name: tRNA wobble cytosine modification namespace: biological_process def: "The process in which a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002102 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: Wikipedia:Podosome is_a: GO:0032991 ! protein-containing complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0002103 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0002104 name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002105 name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002106 name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002107 name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III namespace: biological_process def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] is_a: GO:0000481 ! maturation of 5S rRNA is_a: GO:0031125 ! rRNA 3'-end processing [Term] id: GO:0002108 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0002109 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0002110 name: cotranscriptional mitochondrial rRNA nucleotide insertion namespace: biological_process def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337, PMID:8306965] is_a: GO:0000154 ! rRNA modification is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0002111 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0002112 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd] synonym: "IL-33" NARROW [GOC:mah] synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0002113 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd] synonym: "IL-33 binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0002114 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "IL-33 receptor activity" EXACT [GOC:mah] synonym: "IL-33R" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0002115 name: store-operated calcium entry namespace: biological_process def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. synonym: "calcium ion import" BROAD [] synonym: "capacitative calcium entry" EXACT [] synonym: "SOCE" EXACT [] synonym: "store-operated calcium import" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0002116 name: semaphorin receptor complex namespace: cellular_component def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] synonym: "plexin-neurophilin complex" EXACT [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002117 name: amphibian larval development namespace: biological_process def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/] is_a: GO:0002164 ! larval development [Term] id: GO:0002118 name: aggressive behavior namespace: biological_process def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] synonym: "aggression" EXACT [] xref: Wikipedia:Aggression is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development [Term] id: GO:0002120 name: predatory behavior namespace: biological_process def: "Aggressive behavior involving attack on prey by a predator." [GOC:hjd] synonym: "predatory aggression" EXACT [] synonym: "predatory aggressive behavior" EXACT [] is_a: GO:0002118 ! aggressive behavior is_a: GO:0044366 ! feeding on or from other organism [Term] id: GO:0002121 name: inter-male aggressive behavior namespace: biological_process def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] synonym: "inter-male aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002122 name: fear-induced aggressive behavior namespace: biological_process def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] synonym: "fear-induced aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002123 name: irritable aggressive behavior namespace: biological_process def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] synonym: "irritable aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002124 name: territorial aggressive behavior namespace: biological_process def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] synonym: "territorial aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002125 name: maternal aggressive behavior namespace: biological_process def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] comment: Paternal aggression also exists. Serves to protect the offspring from intruders. synonym: "maternal aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002126 name: instrumental aggressive behavior namespace: biological_process def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] synonym: "instrumental aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002127 name: tRNA wobble base cytosine methylation namespace: biological_process def: "The process in which the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] synonym: "wobble position m5C biosynthesis" EXACT [] is_a: GO:0002101 ! tRNA wobble cytosine modification is_a: GO:0002946 ! tRNA C5-cytosine methylation [Term] id: GO:0002128 name: tRNA nucleoside ribose methylation namespace: biological_process def: "The process that results in the modification of the sugar of a nucleoside in tRNA at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002129 name: wobble position guanine ribose methylation namespace: biological_process def: "The process in which the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation is_a: GO:0002938 ! tRNA guanine ribose methylation [Term] id: GO:0002130 name: wobble position ribose methylation namespace: biological_process def: "The process in which the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002131 name: wobble position cytosine ribose methylation namespace: biological_process def: "The process in which the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002132 name: wobble position uridine ribose methylation namespace: biological_process def: "The process in which the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002133 name: polycystin complex namespace: cellular_component def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002134 name: UTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732] is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002135 name: CTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607] is_a: GO:0032557 ! pyrimidine ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0002136 name: tRNA wobble base lysidine biosynthesis namespace: biological_process def: "The process in which the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. is_a: GO:0002101 ! tRNA wobble cytosine modification [Term] id: GO:0002138 name: retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] synonym: "retinoic acid anabolic process" EXACT [] is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0002139 name: stereocilia coupling link namespace: cellular_component def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] is_a: GO:0097458 ! neuron part relationship: part_of GO:0032421 ! stereocilium bundle [Term] id: GO:0002140 name: stereocilia tip link namespace: cellular_component def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002141 name: stereocilia ankle link namespace: cellular_component def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] is_a: GO:0002139 ! stereocilia coupling link [Term] id: GO:0002142 name: stereocilia ankle link complex namespace: cellular_component def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] is_a: GO:0032991 ! protein-containing complex is_a: GO:0097458 ! neuron part relationship: part_of GO:0002141 ! stereocilia ankle link [Term] id: GO:0002143 name: tRNA wobble position uridine thiolation namespace: biological_process def: "The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] synonym: "wobble position s2U biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0034227 ! tRNA thio-modification [Term] id: GO:0002144 name: cytosolic tRNA wobble base thiouridylase complex namespace: cellular_component def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219] synonym: "Cut1-Cut2 complex" NARROW [] synonym: "tRNA thiouridylase" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0002145 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine pyrophosphate + H2O = hydroxymethylpyrimidine phosphate + phosphate + H(+)." [MetaCyc:RXN0-3543] synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] xref: MetaCyc:RXN0-3543 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0002146 name: obsolete steroid hormone receptor import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "steroid hormone receptor nuclear translocation" NARROW [GOC:mah] is_obsolete: true consider: GO:0006606 consider: GO:0042306 [Term] id: GO:0002147 name: obsolete glucocorticoid receptor import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "glucocorticoid receptor nuclear translocation" NARROW [GOC:mah] is_obsolete: true consider: GO:0042306 [Term] id: GO:0002148 name: hypochlorous acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024] synonym: "HClO metabolic process" EXACT [] synonym: "HOCl metabolic process" EXACT [] synonym: "hypochlorite metabolic process" RELATED [] synonym: "hypochlorous acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0002149 name: hypochlorous acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. synonym: "HClO biosynthetic process" EXACT [] synonym: "HOCl biosynthetic process" EXACT [] synonym: "hypochlorite biosynthetic process" RELATED [] synonym: "hypochlorous acid biosynthesis" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process [Term] id: GO:0002150 name: hypochlorous acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] synonym: "HClO catabolic process" EXACT [] synonym: "HOCl catabolic process" EXACT [] synonym: "hypochlorite catabolic process" RELATED [] synonym: "hypochlorous acid catabolism" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0002151 name: G-quadruplex RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. synonym: "G quadruplex binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:hjd] synonym: "G quartet RNA binding" EXACT [GOC:hjd] synonym: "G-quartet binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0002152 name: bile acid conjugation namespace: biological_process def: "The process in which bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). is_a: GO:0008206 ! bile acid metabolic process [Term] id: GO:0002153 name: steroid receptor RNA activator RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [GOC:vw, PMID:10199399, PMID:15180993] comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). synonym: "SRA binding" EXACT [] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0002154 name: thyroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] synonym: "thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0002155 name: regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002156 name: negative regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "negative regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002157 name: positive regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] synonym: "positive regulation of thyroid hormone mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0002160 name: desmosome maintenance namespace: biological_process def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0002934 ! desmosome organization is_a: GO:0045217 ! cell-cell junction maintenance [Term] id: GO:0002161 name: aminoacyl-tRNA editing activity namespace: molecular_function def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] synonym: "amino acid proofreading activity" RELATED [] synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0002162 name: dystroglycan binding namespace: molecular_function alt_id: GO:0002163 alt_id: GO:0002166 def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] synonym: "alpha-dystroglycan binding" NARROW [] synonym: "beta-dystroglycan binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of an that at birth or hatching is fundamentally unlike its parent and must metamorphose before assuming the adult characters." [GOC:jid, ISBN:0877795088] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0007275 ! multicellular organism development is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002167 name: VRK3/VHR/ERK complex namespace: cellular_component def: "A ternary complex consisting of VRK3, VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002168 name: instar larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002164 ! larval development is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0002169 name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial namespace: cellular_component def: "A mitochondrial protein complex which is capable of 3-methylcrotonyl-CoA carboxylase activity. In mammals, at least, consists as a dodecamer of 6 alpha and 6 beta subunits. MCCC-alpha has a covalently bound biotin essential for the ATP-dependent carboxylation. MCCC-beta possesses carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:bf, GOC:hjd, PMID:15868465, PMID:17360195, PMID:22869039] synonym: "mitochondrial 3-methylcrotonyl-CoA carboxylase holoenzyme" EXACT [PMID:22869039] synonym: "mitochondrial MCCC complex" EXACT [GOC:bf] synonym: "mitochondrial methylcrotonoyl-CoA carboxylase complex" EXACT [GOC:bf] is_a: GO:0098798 ! mitochondrial protein complex is_a: GO:1905202 ! methylcrotonoyl-CoA carboxylase complex [Term] id: GO:0002170 name: high-affinity IgA receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "high affinity IgA receptor activity" EXACT [] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002171 name: low-affinity IgA receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "low affinity IgA receptor activity" EXACT [] is_a: GO:0019766 ! IgA receptor activity [Term] id: GO:0002172 name: high-affinity IgM receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "high affinity IgM receptor activity" EXACT [] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002173 name: low-affinity IgM receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:hjd, GOC:signaling] synonym: "low affinity IgM receptor activity" EXACT [] is_a: GO:0001793 ! IgM receptor activity [Term] id: GO:0002174 name: mammary stem cell proliferation namespace: biological_process def: "The expansion of a mammary stem cell population by cell division. Mammary stem cells are a source of cells for growth of the mammary gland during puberty and gestation. These cells can give rise to both the luminal and myoepithelial cell types of the gland, and can regenerate the entire organ." [PMID:15987436] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0002175 name: protein localization to paranode region of axon namespace: biological_process def: "A cellular protein localization process in which a protein is transported to, or maintained at, the paranode region of an axon." [PMID:18803321] synonym: "protein localisation to paranode region of axon" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0099612 ! protein localization to axon [Term] id: GO:0002176 name: male germ cell proliferation namespace: biological_process def: "The multiplication or reproduction of male germ cells, resulting in the expansion of a cell population." [GOC:hjd] is_a: GO:0036093 ! germ cell proliferation [Term] id: GO:0002177 name: manchette namespace: cellular_component def: "A tubular array of microtubules that extends from the perinuclear ring surrounding the spermatid nucleus to the flagellar axoneme. The manchette may also contain F-actin filaments." [GOC:krc, PMID:15018141, PMID:22319670, PMID:24440897, PMID:26792866] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0002178 name: palmitoyltransferase complex namespace: cellular_component def: "A protein complex with palmitoyltransferase activity." [GOC:hjd] is_a: GO:1990234 ! transferase complex [Term] id: GO:0002179 name: homodimeric serine palmitoyltransferase complex namespace: cellular_component def: "A homodimeric complex which transfers a palmitoyl group onto serine, forming 3-dehydro-D-sphinganine." [GOC:hjd] comment: This complex occurs primarily in bacteria. is_a: GO:0017059 ! serine C-palmitoyltransferase complex [Term] id: GO:0002180 name: 5-lipoxygenase complex namespace: cellular_component def: "An nuclear membrane protein complex having arachidonate 5-lipoxygenase activity." [PMID:19075240] is_a: GO:0044453 ! nuclear membrane part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0002181 name: cytoplasmic translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in the cytoplasm. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein." [GOC:hjd] comment: Note that this term applies to translation performed by cytoplasmic ribosomes, which is distinct from translation performed by organellar ribosomes. For mitochondrial translation, consider GO:0032543 'mitochondrial translation' or its child terms. subset: goslim_pombe subset: goslim_yeast is_a: GO:0006412 ! translation [Term] id: GO:0002182 name: cytoplasmic translational elongation namespace: biological_process def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis in the cytoplasm." [GOC:hjd] is_a: GO:0006414 ! translational elongation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002183 name: cytoplasmic translational initiation namespace: biological_process def: "The process preceding formation of the peptide bond between the first two amino acids of a protein in the cytoplasm. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [GOC:hjd] is_a: GO:0006413 ! translational initiation relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002184 name: cytoplasmic translational termination namespace: biological_process def: "The process resulting in the release of a polypeptide chain from the ribosome in the cytoplasm, usually in response to a termination codon." [GOC:hjd] is_a: GO:0006415 ! translational termination relationship: part_of GO:0002181 ! cytoplasmic translation [Term] id: GO:0002185 name: creatine kinase complex namespace: cellular_component def: "A protein complex having creatine kinase activity." [GOC:hjd] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0002186 name: cytosolic creatine kinase complex namespace: cellular_component def: "A dimeric protein complex having creatine kinase activity." [PMID:173175] is_a: GO:0002185 ! creatine kinase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0002187 name: mitochondrial creatine kinase complex namespace: cellular_component def: "An octomeric protein complex having creatine kinase activity." [PMID:16236486] is_a: GO:0002185 ! creatine kinase complex is_a: GO:0098798 ! mitochondrial protein complex [Term] id: GO:0002188 name: translation reinitiation namespace: biological_process def: "A gene-specific translational control mechanism where the small ribosomal subunit remains attached to the mRNA following termination of translation, then resumes scanning on the same mRNA molecule and initiates again at a downstream start site. Reinitiation depends on de novo recruitment of the ternary complex that is required to recognize the next AUG codon." [PMID:18056426, PMID:18765792] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002189 name: ribose phosphate diphosphokinase complex namespace: cellular_component def: "A protein complex having ribose phosphate diphosphokinase activity." [GO:hjd, PMID:9348095] comment: In mammals, the complex consists of two non-identical catalytic subunits and two non-identical regulatory subunits. synonym: "phosphoribosylpyrophosphate synthetase complex" EXACT [PMID:9348095] synonym: "PRPP synthetase complex" EXACT [PMID:9348095] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0002190 name: cap-independent translational initiation namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits in a Cap and 5' end independent fashion before an AUG codon is encountered in an appropriate sequence context to initiate mRNA or circRNA translation." [PMID:17284590] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002191 name: cap-dependent translational initiation namespace: biological_process def: "The process where the \"Cap structure\" (composed of a 7- methylguanosine (m7G) group and associated cap-binding proteins) located at the 5' end of an mRNA molecule, which serves as a \"molecular tag\" that marks the spot where the 40S ribosomal subunit is recruited and will then scan in a 5' to 3' direction until an AUG codon is encountered in an appropriate sequence context to initiate mRNA translation." [PMID:17284590, PMID:19604130] is_a: GO:0002183 ! cytoplasmic translational initiation [Term] id: GO:0002192 name: IRES-dependent translational initiation of linear mRNA namespace: biological_process def: "The process where translation initiation recruits the 40S ribosomal subunits via an internal ribosome entry segment (IRES) before an AUG codon is encountered in an appropriate sequence context to initiate linear mRNA translation." [PMID:17284590] is_a: GO:0110017 ! cap-independent translational initiation of linear mRNA [Term] id: GO:0002193 name: MAML1-RBP-Jkappa- ICN1 complex namespace: cellular_component def: "A protein complex that consists of the intracellular domain of Notch1 (ICN1), the DNA-binding transcription factor RBP-Jkappa, and the transcriptional coactivator Mastermind-like-1 (MAML1); the complex is involved in transcriptional activation in response to Notch-mediated signaling." [CORUM:2949, PMID:16510869] synonym: "MAML1-CSL-ICN1" EXACT [] synonym: "MAML1-CSL-Notch1 complex" EXACT [] synonym: "MAML1-RBP-Jkappa-Notch1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002194 name: hepatocyte cell migration namespace: biological_process def: "The orderly movement of a hepatocyte during the development of the liver. Hepatocytes emerge from the hepatic epithelium, populating the septum transversum and lateral mesenchymal areas of the hepatic lobes." [CL:0000182, PMID:9794819] is_a: GO:0016477 ! cell migration [Term] id: GO:0002195 name: 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine-tRNA biosynthesis namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A), a modified nucleoside present in position 37 (adjacent to and 3' of the anticodon) of tRNAs." [UniPathway:UPA00729] comment: In Salmonella typhimurium, 2-methylthio-N-6-(cis-hydroxy)isopentenyl adenosine (ms2io6A; also referred to as 2-methylthio cis-ribozeatin) is found in tRNA, most likely in the species that have ms2i6A in E. coli. is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002196 name: Ser-tRNA(Ala) hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of misacylated Ser-tRNA(Ala)." [GOC:hjd, PMID:21285375] is_a: GO:0002161 ! aminoacyl-tRNA editing activity [Term] id: GO:0002197 name: xanthine dehydrogenase complex namespace: cellular_component def: "A homodimeric protein complex having xanthine dehydrogenase activity." [GOC:hjd, PMID:8224915] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0002198 name: obsolete S/G2 transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. The transition from a cell in the S phase to the G2 phase." [GOC:hjd, GOC:mtg_cell_cycle, PMID:15161931] comment: This term was made obsolete because it does not refer to a real biological process. synonym: "S/G2 transition of mitotic cell cycle" EXACT [] is_obsolete: true [Term] id: GO:0002199 name: zona pellucida receptor complex namespace: cellular_component def: "A multisubunit complex comprising the chaperonin-containing T-complex and several other components involved in mediating sperm-oocyte Interaction." [GOC:hjd, PMID:21880732] synonym: "sperm protein complex I" RELATED [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002201 name: somatic diversification of DSCAM-based immune receptors namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the DSCAM-based immune receptors of insects." [GOC:add, PMID:16261174] comment: Note that this type of immune receptor may not be limited to insects. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002202 name: somatic diversification of variable lymphocyte receptors of jawless fish namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish." [GOC:add, PMID:16373579] comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002203 name: proteolysis by cytosolic proteases associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002205 name: somatic hypermutation of immunoglobulin genes involved in immune response namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:11205333, PMID:14991701] synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: part_of GO:0002344 ! B cell affinity maturation [Term] id: GO:0002206 name: gene conversion of immunoglobulin genes namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes" EXACT [] is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion is_a: GO:0016445 ! somatic diversification of immunoglobulins is_a: GO:0035822 ! gene conversion [Term] id: GO:0002207 name: gene conversion of immunoglobulin genes involved in immune response namespace: biological_process def: "The somatic process in which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes during immune response" RELATED [] synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002206 ! gene conversion of immunoglobulin genes is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins after induction, and contributes to an immune response." [GOC:add, ISBN:0781735149, PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002209 name: behavioral defense response namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural defense response" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0007610 ! behavior [Term] id: GO:0002210 name: behavioral response to wounding namespace: biological_process def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural response to wounding" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009611 ! response to wounding [Term] id: GO:0002211 name: behavioral defense response to insect namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "behavioural defense response to insect" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002213 ! defense response to insect is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002212 name: behavioral defense response to nematode namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] synonym: "behavioural defense response to nematode" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002215 ! defense response to nematode is_a: GO:0051705 ! multi-organism behavior [Term] id: GO:0002213 name: defense response to insect namespace: biological_process alt_id: GO:0002214 def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process alt_id: GO:0002216 def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002218 name: activation of innate immune response namespace: biological_process alt_id: GO:0002219 def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149, PMID:15199967, PMID:16177805] comment: This term was added by GO_REF:0000022. is_a: GO:0002253 ! activation of immune response is_a: GO:0045089 ! positive regulation of innate immune response [Term] id: GO:0002220 name: innate immune response activating cell surface receptor signaling pathway namespace: biological_process def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149, PMID:15199967] synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002221 name: pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] synonym: "PRR signaling pathway" EXACT [ISBN:0781735149, PMID:15199967, PMID:15728447] is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002222 name: stimulatory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002223 name: stimulatory C-type lectin receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002224 name: toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. synonym: "TLR signaling pathway" EXACT [ISBN:0781735149] synonym: "toll-like receptor signalling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002760 ! positive regulation of antimicrobial humoral response is_a: GO:0002784 ! regulation of antimicrobial peptide production relationship: positively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002229 name: defense response to oomycetes namespace: biological_process def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] is_a: GO:0002239 ! response to oomycetes is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002230 name: positive regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "activation of antiviral response by host" NARROW [] synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of antiviral response by host" NARROW [] synonym: "up regulation of antiviral response by host" EXACT [] synonym: "up-regulation of antiviral response by host" EXACT [] synonym: "upregulation of antiviral response by host" EXACT [] is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0002231 name: detection of oomycetes namespace: biological_process def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] is_a: GO:0002239 ! response to oomycetes is_a: GO:0098543 ! detection of other organism [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002234 name: detection of endoplasmic reticulum overloading namespace: biological_process def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] synonym: "detection of ER overloading" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002235 name: detection of unfolded protein namespace: biological_process def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0002236 name: detection of misfolded protein namespace: biological_process def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051788 ! response to misfolded protein [Term] id: GO:0002237 name: response to molecule of bacterial origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] synonym: "response to bacteria associated molecule" EXACT [] synonym: "response to bacterial associated molecule" EXACT [] synonym: "response to bacterium associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0009617 ! response to bacterium [Term] id: GO:0002238 name: response to molecule of fungal origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] synonym: "response to fungus associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0002239 name: response to oomycetes namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] is_a: GO:0051707 ! response to other organism [Term] id: GO:0002240 name: response to molecule of oomycetes origin namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] synonym: "response to oomycetes associated molecule" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0043207 ! response to external biotic stimulus relationship: part_of GO:0002239 ! response to oomycetes [Term] id: GO:0002241 name: response to parasitic plant namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0002242 name: defense response to parasitic plant namespace: biological_process def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0098542 ! defense response to other organism [Term] id: GO:0002243 name: detection of parasitic plant namespace: biological_process def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0009602 ! detection of symbiont [Term] id: GO:0002244 name: hematopoietic progenitor cell differentiation namespace: biological_process def: "The process in which precursor cell type acquires the specialized features of a hematopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, GOC:rl, ISBN:0781735149, PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hemopoietic progenitor cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing relationship: part_of GO:0090594 ! inflammatory response to wounding [Term] id: GO:0002247 name: clearance of damaged tissue involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002248 name: connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] is_a: GO:0097709 ! connective tissue replacement relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response mediated by cells expressing specific receptors for antigen produced through a somatic diversification process, and allowing for an enhanced secondary response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "acquired immune response" EXACT [ISBN:068340007X] synonym: "immune memory response" EXACT [GOC:add] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that can potentially contribute to an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process [Term] id: GO:0002253 name: activation of immune response namespace: biological_process def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002254 name: kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002526 ! acute inflammatory response is_a: GO:0072376 ! protein activation cascade [Term] id: GO:0002255 name: tissue kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] synonym: "glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002256 name: regulation of kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:2000257 ! regulation of protein activation cascade relationship: regulates GO:0002254 ! kinin cascade [Term] id: GO:0002257 name: negative regulation of kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "down regulation of kinin cascade" EXACT [] synonym: "down-regulation of kinin cascade" EXACT [] synonym: "downregulation of kinin cascade" EXACT [] synonym: "inhibition of kinin cascade" NARROW [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:2000258 ! negative regulation of protein activation cascade relationship: negatively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002258 name: positive regulation of kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "activation of kinin cascade" NARROW [] synonym: "stimulation of kinin cascade" NARROW [] synonym: "up regulation of kinin cascade" EXACT [] synonym: "up-regulation of kinin cascade" EXACT [] synonym: "upregulation of kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:2000259 ! positive regulation of protein activation cascade relationship: positively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002259 name: endothelial cell activation within high endothelial venule involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] is_a: GO:0002264 ! endothelial cell activation involved in immune response [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002261 name: mucosal lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [CL:0000763, GOC:add] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0001775 ! cell activation [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0002266 ! follicular dendritic cell activation [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0097028 ! dendritic cell differentiation [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045575 ! basophil activation [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149, PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "macrophage activation during immune response" RELATED [GOC:tb] synonym: "macrophage polarization involved in immune response" EXACT [] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process in which an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0002291 name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development involved in immune response" RELATED [GOC:add] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002295 name: T-helper cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149] synonym: "T-helper cell fate commitment" EXACT [] synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149] synonym: "Thp lineage commitment" RELATED [ISBN:0781735149] is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0042093 ! T-helper cell differentiation [Term] id: GO:0002296 name: T-helper 1 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149] synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149] synonym: "Th1 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0002297 name: T-helper 2 cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149] synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149] synonym: "Th2 fate commitment" EXACT [ISBN:0781735149] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta T cell development involved in immune response" RELATED [GOC:add] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process in which an antigenically naive gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta T cell development involved in immune response" RELATED [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, gamma-delta intraepithelial T cell development" RELATED [GOC:add] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD8-positive, alpha-beta cytotoxic T cell development" RELATED [GOC:add] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B cell development involved in immune response" RELATED [GOC:add] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "germinal center B cell development" RELATED [GOC:add] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "marginal zone B cell development" RELATED [GOC:add] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process in which a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "follicular B cell development" RELATED [GOC:add] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "plasma cell development" RELATED [GOC:add] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process in which a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "memory B cell development" RELATED [GOC:add] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response is_a: GO:0090715 ! immunological memory formation process [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hematopoietic progenitor cell differentiation [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process in which a naive natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002326 name: B cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte lineage commitment" EXACT [] synonym: "B-cell lineage commitment" EXACT [] synonym: "B-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149, PMID:16551251] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "immature B cell development" RELATED [GOC:add] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149] synonym: "pro-B cell development" RELATED [GOC:add] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "pre-B cell development" RELATED [GOC:add] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002330 name: pre-B cell receptor expression namespace: biological_process def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:add, GOC:jal, ISBN:0781735149] is_a: GO:0010467 ! gene expression relationship: part_of GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002331 name: pre-B cell allelic exclusion namespace: biological_process def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "pre-B lymphocyte allelic exclusion" EXACT [] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "transitional stage B cell development" RELATED [GOC:add] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002333 name: transitional one stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T1 stage B cell differentiation" EXACT [] synonym: "transitional one stage B cell development" RELATED [GOC:add] synonym: "transitional one stage B lymphocyte differentiation" EXACT [] synonym: "transitional one stage B-cell differentiation" EXACT [] synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002334 name: transitional two stage B cell differentiation namespace: biological_process def: "The process in which immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T2 stage B cell differentiation" EXACT [] synonym: "transitional two stage B cell development" RELATED [GOC:add] synonym: "transitional two stage B lymphocyte differentiation" EXACT [] synonym: "transitional two stage B-cell differentiation" EXACT [] synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process in which transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] synonym: "mature cell development" RELATED [GOC:add] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002336 name: B-1 B cell lineage commitment namespace: biological_process def: "The process in which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149] synonym: "B-1 B lymphocyte lineage commitment" EXACT [] synonym: "B-1 B-cell lineage commitment" EXACT [] synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] is_a: GO:0002326 ! B cell lineage commitment relationship: part_of GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1a B cell development" RELATED [GOC:add] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process in which B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B-1b B cell development" RELATED [GOC:add] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002340 name: central B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] synonym: "central B lymphocyte selection" EXACT [] synonym: "central B-cell selection" EXACT [] synonym: "central B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002341 name: central B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte anergy" EXACT [] synonym: "central B-cell anergy" EXACT [] synonym: "central B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002342 name: central B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis] synonym: "central B lymphocyte deletion" EXACT [] synonym: "central B-cell deletion" EXACT [] synonym: "central B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process in which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002345 name: peripheral B cell receptor editing namespace: biological_process def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] synonym: "peripheral B lymphocyte receptor editing" EXACT [] synonym: "peripheral B-cell receptor editing" EXACT [] synonym: "peripheral B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002346 name: B cell positive selection namespace: biological_process def: "Any process in which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] synonym: "B lymphocyte positive selection" EXACT [] synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002347 name: response to tumor cell namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0002348 name: central B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "central B lymphocyte positive selection" EXACT [] synonym: "central B-cell positive selection" EXACT [] synonym: "central B-lymphocyte positive selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002350 name: peripheral B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process in which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "peripheral B lymphocyte positive selection" EXACT [] synonym: "peripheral B-cell positive selection" EXACT [] synonym: "peripheral B-lymphocyte positive selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002352 name: B cell negative selection namespace: biological_process def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] synonym: "B lymphocyte negative selection" EXACT [] synonym: "B-cell negative selection" EXACT [] synonym: "B-lymphocyte negative selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002353 name: plasma kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002354 name: central B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte negative selection" EXACT [] synonym: "central B-cell negative selection" EXACT [] synonym: "central B-lymphocyte negative selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002355 name: detection of tumor cell namespace: biological_process def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002356 name: peripheral B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte negative selection" EXACT [] synonym: "peripheral B-cell negative selection" EXACT [] synonym: "peripheral B-lymphocyte negative selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002357 name: defense response to tumor cell namespace: biological_process def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006952 ! defense response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation relationship: part_of GO:0042592 ! homeostatic process [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002360 name: T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte lineage commitment" EXACT [] synonym: "T-cell lineage commitment" EXACT [] synonym: "T-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002362 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment namespace: biological_process def: "The process in which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] is_a: GO:0043373 ! CD4-positive, alpha-beta T cell lineage commitment relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002363 name: alpha-beta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149] synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "alpha-beta T-cell lineage commitment" EXACT [] synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002364 name: NK T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149] synonym: "natural killer T lymphocyte lineage commitment" EXACT [] synonym: "natural killer T-cell lineage commitment" EXACT [] synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] synonym: "NK T lymphocyte lineage commitment" EXACT [] synonym: "NK T-cell lineage commitment" EXACT [] synonym: "NK T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002363 ! alpha-beta T cell lineage commitment relationship: part_of GO:0001865 ! NK T cell differentiation [Term] id: GO:0002365 name: gamma-delta T cell lineage commitment namespace: biological_process def: "The process in which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149] synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] synonym: "gamma-delta T-cell lineage commitment" EXACT [] synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. synonym: "cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149] synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149] synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149] is_a: GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002374 name: cytokine secretion involved in immune response namespace: biological_process def: "The regulated release of cytokines from a cell that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002375 name: cytokine biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149] synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production" EXACT [] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002378 name: immunoglobulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis" EXACT [] synonym: "antibody biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0002379 name: immunoglobulin biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149] synonym: "antibody biosynthesis during immune response" RELATED [] synonym: "antibody biosynthetic process during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002378 ! immunoglobulin biosynthetic process relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002380 name: immunoglobulin secretion involved in immune response namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:9185563] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph] is_a: GO:0048305 ! immunoglobulin secretion relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "antibody production during immune response" RELATED [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] is_a: GO:0002377 ! immunoglobulin production relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002382 name: regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002383 name: immune response in brain or nervous system namespace: biological_process def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149] synonym: "immune response in MALT" EXACT [] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149] synonym: "immune response in GALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue [Term] id: GO:0002390 name: platelet activating factor production namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] is_a: GO:0001816 ! cytokine production [Term] id: GO:0002391 name: platelet activating factor production involved in inflammatory response namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor production involved in acute inflammatory response" BROAD [] is_a: GO:0002390 ! platelet activating factor production is_a: GO:0002534 ! cytokine production involved in inflammatory response [Term] id: GO:0002392 name: platelet activating factor secretion namespace: biological_process def: "The regulated release of platelet activating factor by a cell." [GOC:add, ISBN:0781735149] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0015893 ! drug transport is_a: GO:0015914 ! phospholipid transport is_a: GO:0050663 ! cytokine secretion [Term] id: GO:0002393 name: lysosomal enzyme production involved in inflammatory response namespace: biological_process def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] synonym: "lysosomal enzyme production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "production of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149] synonym: "immune response in NALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0002397 name: MHC class I protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002398 name: MHC class Ib protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149] synonym: "tolerance induction in MALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002404 name: antigen sampling in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] synonym: "antigen sampling in MALT" EXACT [] synonym: "antigen transport in MALT" RELATED [] synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002405 name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] synonym: "antigen sampling by dendritic cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002406 name: antigen sampling by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] synonym: "antigen sampling by M cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [CL:0000451, GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0036336 ! dendritic cell migration [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002411 name: T cell tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002413 ! tolerance induction to tumor cell is_a: GO:0002424 ! T cell mediated immune response to tumor cell is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002412 name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149, PMID:12843411] synonym: "antigen transcytosis by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] is_a: GO:0045056 ! transcytosis relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue [Term] id: GO:0002413 name: tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002414 name: immunoglobulin transcytosis in epithelial cells namespace: biological_process def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] is_a: GO:0045056 ! transcytosis [Term] id: GO:0002415 name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor namespace: biological_process def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149, ISBN:081533642X, PMID:16048543] synonym: "antibody transcytosis mediated by pIgR" EXACT [] synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002416 name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor namespace: biological_process def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149, ISBN:081533642X] synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells [Term] id: GO:0002417 name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis [Term] id: GO:0002418 name: immune response to tumor cell namespace: biological_process def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006955 ! immune response [Term] id: GO:0002419 name: T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001913 ! T cell mediated cytotoxicity is_a: GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002420 name: natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell is_a: GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0002421 name: B cell antigen processing and presentation following pinocytosis namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002422 name: immune response in urogenital tract namespace: biological_process def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002423 name: natural killer cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002418 ! immune response to tumor cell [Term] id: GO:0002424 name: T cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149, PMID:16730260] comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002425 name: tolerance induction in urogenital tract namespace: biological_process def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] is_a: GO:0002422 ! immune response in urogenital tract is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002426 name: immunoglobulin production in mucosal tissue namespace: biological_process def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] synonym: "antibody production in mucosal tissue" EXACT [] is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002385 ! mucosal immune response [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002428 name: antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002429 name: immune response-activating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002757 ! immune response-activating signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002430 name: complement receptor mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "complement receptor mediated signalling pathway" EXACT [] synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002431 name: Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X, ISBN:0721601464, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002433 name: immune response-regulating cell surface receptor signaling pathway involved in phagocytosis namespace: biological_process def: "An immune response-regulating cell surface receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes." [GO_REF:0000022, GOC:add, GOC:bf, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-regulating cell surface receptor signalling pathway involved in phagocytosis" EXACT [GOC:mah] synonym: "phagocytosis triggered by activation of immune response cell surface activating receptor" EXACT [GO_REF:0000022] is_a: GO:0002252 ! immune effector process is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0002434 name: immune complex clearance namespace: biological_process def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process [Term] id: GO:0002435 name: immune complex clearance by erythrocytes namespace: biological_process def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002436 name: immune complex clearance by monocytes and macrophages namespace: biological_process def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002439 name: chronic inflammatory response to antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002376 ! immune system process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "serotonin release involved in inflammatory response" RELATED [GOC:tb] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process in which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0019724 ! B cell mediated immunity [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002452 name: B cell receptor editing namespace: biological_process def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte receptor editing" EXACT [] synonym: "B-cell receptor editing" EXACT [] synonym: "B-lymphocyte receptor editing" EXACT [] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002453 name: peripheral B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149] synonym: "peripheral B lymphocyte anergy" EXACT [] synonym: "peripheral B-cell anergy" EXACT [] synonym: "peripheral B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002454 name: peripheral B cell deletion namespace: biological_process def: "The deletion of B cells by apoptotic process occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "peripheral B lymphocyte deletion" EXACT [] synonym: "peripheral B-cell deletion" EXACT [] synonym: "peripheral B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002455 name: humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "circulating antibody mediated immune response" EXACT [] synonym: "circulating immunoglobulin mediated immune response" EXACT [] synonym: "humoral defence mechanism" RELATED [] synonym: "humoral immune response mediated by circulating antibody" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process in which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0002456 ! T cell mediated immunity [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002459 name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] synonym: "adaptive immune response in jawless fish" EXACT [] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response mediated by lymphocytes expressing specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains. Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies) produced by B cells. The first encounter with antigen elicits a primary immune response that is slow and not of great magnitude. T and B cells selected by antigen become activated and undergo clonal expansion. A fraction of antigen-reactive T and B cells become memory cells, whereas others differentiate into effector cells. The memory cells generated during the primary response enable a much faster and stronger secondary immune response upon subsequent exposures to the same antigen (immunological memory). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149, ISBN:1405196831] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002463 name: central tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002508 ! central tolerance induction [Term] id: GO:0002464 name: peripheral tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002466 name: peripheral tolerance induction to self antigen namespace: biological_process def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process in which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process in which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process in which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process in which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002473 name: non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "The process in which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002475 name: antigen processing and presentation via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002476 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0002477 name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002479 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002480 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002481 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002482 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002484 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002485 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002486 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002487 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002488 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib [Term] id: GO:0002489 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002490 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002492 name: peptide antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002493 name: lipid antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0065005 ! protein-lipid complex assembly relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002494 name: lipid antigen transport namespace: biological_process def: "The directed movement of a lipid antigen into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002497 name: proteasomal proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002498 name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15224092, PMID:15771591] synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002499 name: proteolysis within endosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002501 name: peptide antigen assembly with MHC protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0002396 ! MHC protein complex assembly relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002502 name: peptide antigen assembly with MHC class I protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002397 ! MHC class I protein complex assembly relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002503 name: peptide antigen assembly with MHC class II protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149, PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002505 name: antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "The process in which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002506 name: polysaccharide assembly with MHC class II protein complex namespace: biological_process def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240] is_a: GO:0065006 ! protein-carbohydrate complex assembly relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002508 name: central tolerance induction namespace: biological_process def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002509 name: central tolerance induction to self antigen namespace: biological_process def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149, PMID:16460922] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002510 name: central B cell tolerance induction namespace: biological_process def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte tolerance induction" EXACT [] synonym: "central B-cell tolerance induction" EXACT [] synonym: "central B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002511 name: central B cell receptor editing namespace: biological_process def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte receptor editing" EXACT [] synonym: "central B-cell receptor editing" EXACT [] synonym: "central B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002512 name: central T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149] synonym: "central T lymphocyte tolerance induction" EXACT [] synonym: "central T-cell tolerance induction" EXACT [] synonym: "central T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002513 name: tolerance induction to self antigen namespace: biological_process def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149, PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptotic process is_a: GO:1902742 ! apoptotic process involved in development relationship: part_of GO:0002514 ! B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149, PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002518 name: lymphocyte chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149, PMID:15122201] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a leukocyte. A leukocyte is an achromatic cell of the myeloid or lymphoid lineages capable of ameboid movement, found in blood or other tissue." [CL:0000738, GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149, PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149] synonym: "hypersensitivity response" RELATED [ISBN:0781735149] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002525 name: acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002527 name: vasodilation involved in acute inflammatory response namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002529 name: regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] is_a: GO:0002256 ! regulation of kinin cascade relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002530 name: regulation of systemic arterial blood pressure involved in acute-phase response namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] synonym: "blood pressure regulation during acute phase response" RELATED [] synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] is_a: GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002531 name: regulation of heart contraction involved in acute-phase response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] synonym: "regulation of cardiac contraction during acute phase response" RELATED [] synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] is_a: GO:0008016 ! regulation of heart contraction relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002533 name: lysosomal enzyme secretion involved in inflammatory response namespace: biological_process def: "The regulated release of lysosomal enzymes by a cell as part of an inflammatory response." [GOC:jal, PMID:11836514] synonym: "lysosomal enzyme secretion involved in acute inflammatory response" RELATED [GOC:mah] synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] synonym: "secretion of lysosomal enzymes involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0033299 ! secretion of lysosomal enzymes relationship: part_of GO:0002393 ! lysosomal enzyme production involved in inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002535 name: platelet activating factor secretion involved in inflammatory response namespace: biological_process def: "The regulated release of platelet activating factor by a cell as part of an inflammatory response." [GOC:add, ISBN:0781735149] synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD [] is_a: GO:0002392 ! platelet activating factor secretion relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "oxidative burst during acute inflammatory response" BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0002537 name: nitric oxide production involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "nitric oxide production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] synonym: "production of nitric oxide involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: arachidonic acid metabolite production involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "arachidonic acid metabolite production involved in acute inflammatory response" BROAD [GOC:mah] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] synonym: "production of arachidonic acid metabolites involved in inflammatory response" EXACT [GOC:curators] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! arachidonic acid metabolite production involved in inflammatory response [Term] id: GO:0002541 name: activation of plasma proteins involved in acute inflammatory response namespace: biological_process def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149] is_a: GO:0016485 ! protein processing relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002542 name: Factor XII activation namespace: biological_process def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] synonym: "Hageman factor activation" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0010954 ! positive regulation of protein processing relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response [Term] id: GO:0002543 name: activation of blood coagulation via clotting cascade namespace: biological_process def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149] synonym: "activation of clotting cascade" EXACT [] is_a: GO:0030194 ! positive regulation of blood coagulation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002545 name: chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002546 name: negative regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002547 name: positive regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0071674 ! mononuclear cell migration is_a: GO:0097529 ! myeloid leukocyte migration [Term] id: GO:0002549 name: negative regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002550 name: positive regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis is_a: GO:0097531 ! mast cell migration [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] synonym: "serotonin release by mast cell" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0046907 ! intracellular transport is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0046907 ! intracellular transport is_a: GO:0140029 ! exocytic process relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149] synonym: "serotonin release by platelet" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149] synonym: "serotonin release by basophil" RELATED [GOC:tb] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149] is_a: GO:0002441 ! histamine secretion involved in inflammatory response is_a: GO:0140029 ! exocytic process relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002558 name: type I hypersensitivity mediated by mast cells namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002448 ! mast cell mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002559 name: type I hypersensitivity mediated by basophils namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] is_a: GO:0002560 ! basophil mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149] is_a: GO:0002276 ! basophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002560 ! basophil mediated immunity [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process in which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149, PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002563 name: somatic diversification of immune receptors via alternate splicing namespace: biological_process def: "The process in which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002564 name: alternate splicing of immunoglobulin genes namespace: biological_process def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149, PMID:9185563] synonym: "alternate splicing of antibody genes" EXACT [] is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002565 name: somatic diversification of immune receptors via gene conversion namespace: biological_process def: "The process in which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process in which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149, PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002567 name: somatic diversification of FREP-based immune receptors namespace: biological_process def: "The process that results in the generation of sequence diversity of the FREP-based immune receptors of snails." [GOC:add, PMID:16102575] comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002568 name: somatic diversification of T cell receptor genes namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of T cell receptor genes." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002569 name: somatic diversification of immune receptors by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002570 name: somatic diversification of immunoglobulin genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of antibody genes by N region addition" EXACT [] is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002571 name: somatic diversification of T cell receptor genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149] synonym: "somatic diversification of TCR genes by N region addition" EXACT [] is_a: GO:0002568 ! somatic diversification of T cell receptor genes is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149] synonym: "pro-T lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0071621 ! granulocyte chemotaxis [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process relationship: negatively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process relationship: positively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002592 name: regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002593 name: negative regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002594 name: positive regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002595 name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002596 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002597 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002598 name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002599 name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002600 name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002601 name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002602 name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002603 name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002619 name: regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002620 name: negative regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002621 name: positive regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation is_a: GO:0002713 ! negative regulation of B cell mediated immunity relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation is_a: GO:0002714 ! positive regulation of B cell mediated immunity relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002710 ! negative regulation of T cell mediated immunity relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation is_a: GO:0002711 ! positive regulation of T cell mediated immunity relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:1903050 ! regulation of proteolysis involved in cellular protein catabolic process relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:1903051 ! negative regulation of proteolysis involved in cellular protein catabolic process relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:1903052 ! positive regulation of proteolysis involved in cellular protein catabolic process relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002432 ! granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002698 ! negative regulation of immune effector process relationship: negatively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002699 ! positive regulation of immune effector process relationship: positively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0022603 ! regulation of anatomical structure morphogenesis relationship: regulates GO:0002467 ! germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002640 name: regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002641 name: negative regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] is_a: GO:0002638 ! negative regulation of immunoglobulin production is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002642 name: positive regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "activation of immunoglobulin biosynthetic process" NARROW [] synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] is_a: GO:0002639 ! positive regulation of immunoglobulin production is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0002507 ! tolerance induction [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0051094 ! positive regulation of developmental process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002646 name: regulation of central tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002647 name: negative regulation of central tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "down regulation of central tolerance induction" EXACT [] synonym: "down-regulation of central tolerance induction" EXACT [] synonym: "downregulation of central tolerance induction" EXACT [] synonym: "inhibition of central tolerance induction" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: negatively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002648 name: positive regulation of central tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "activation of central tolerance induction" NARROW [] synonym: "stimulation of central tolerance induction" NARROW [] synonym: "up regulation of central tolerance induction" EXACT [] synonym: "up-regulation of central tolerance induction" EXACT [] synonym: "upregulation of central tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002649 name: regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002650 name: negative regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "down regulation of tolerance induction to self antigen" EXACT [] synonym: "down-regulation of tolerance induction to self antigen" EXACT [] synonym: "downregulation of tolerance induction to self antigen" EXACT [] synonym: "inhibition of tolerance induction to self antigen" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002651 name: positive regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "activation of tolerance induction to self antigen" NARROW [] synonym: "stimulation of tolerance induction to self antigen" NARROW [] synonym: "up regulation of tolerance induction to self antigen" EXACT [] synonym: "up-regulation of tolerance induction to self antigen" EXACT [] synonym: "upregulation of tolerance induction to self antigen" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response relationship: regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction relationship: positively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: negatively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: positively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: negatively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction relationship: positively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002870 ! T cell anergy [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: regulates GO:0002515 ! B cell anergy [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy relationship: negatively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy relationship: positively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response relationship: regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response relationship: negatively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response relationship: positively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149, PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002680 name: pro-T cell lineage commitment namespace: biological_process def: "The process in which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149] synonym: "pro-T cell fate commitment" EXACT [] synonym: "pro-T lymphocyte fate commitment" EXACT [] synonym: "pro-T lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0002572 ! pro-T cell differentiation [Term] id: GO:0002681 name: somatic recombination of T cell receptor gene segments namespace: biological_process def: "The process in which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of TCR gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002568 ! somatic diversification of T cell receptor genes [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis relationship: regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002691 name: regulation of cellular extravasation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration relationship: regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002692 name: negative regulation of cellular extravasation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "down regulation of cellular extravasation" EXACT [] synonym: "down-regulation of cellular extravasation" EXACT [] synonym: "downregulation of cellular extravasation" EXACT [] synonym: "inhibition of cellular extravasation" NARROW [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: negatively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002693 name: positive regulation of cellular extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "activation of cellular extravasation" NARROW [] synonym: "stimulation of cellular extravasation" NARROW [] synonym: "up regulation of cellular extravasation" EXACT [] synonym: "up-regulation of cellular extravasation" EXACT [] synonym: "upregulation of cellular extravasation" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation relationship: positively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0002682 ! regulation of immune system process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045845 def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0030102 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045846 def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: negatively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production relationship: positively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: negatively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production relationship: positively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002739 name: regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050707 ! regulation of cytokine secretion relationship: regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002740 name: negative regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine secretion during immune response" RELATED [] synonym: "down-regulation of cytokine secretion during immune response" RELATED [] synonym: "downregulation of cytokine secretion during immune response" RELATED [] synonym: "inhibition of cytokine secretion during immune response" NARROW [] synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050710 ! negative regulation of cytokine secretion relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002741 name: positive regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "activation of cytokine secretion during immune response" NARROW [] synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine secretion during immune response" NARROW [] synonym: "up regulation of cytokine secretion during immune response" RELATED [] synonym: "up-regulation of cytokine secretion during immune response" RELATED [] synonym: "upregulation of cytokine secretion during immune response" RELATED [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050715 ! positive regulation of cytokine secretion relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002742 name: regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0042035 ! regulation of cytokine biosynthetic process relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002743 name: negative regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002744 name: positive regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002746 name: antigen processing and presentation following pinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002747 name: antigen processing and presentation following phagocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002748 name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149] synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002749 name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149, PMID:15596122] synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] is_a: GO:0002747 ! antigen processing and presentation following phagocytosis is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen [Term] id: GO:0002750 name: antigen processing and presentation following macropinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002751 name: antigen processing and presentation following receptor mediated endocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002752 name: cell surface pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a cell surface pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "cell surface PAMP receptor signaling pathway" EXACT [] synonym: "cell surface pathogen receptor signaling pathway" EXACT [] synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] synonym: "cell surface PRR signaling pathway" EXACT [] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002753 name: cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a cytoplasmic pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] synonym: "cytoplasmic PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0002754 name: intracellular vesicle pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an intracellular vesicle pattern recognition receptor (PRR) binding to one of its physiological ligands. PRRs bind pathogen-associated molecular pattern (PAMPs), structures conserved among microbial species, or damage-associated molecular pattern (DAMPs), endogenous molecules released from damaged cells." [GOC:add, GOC:ar, ISBN:0781735149, PMID:15199967] synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] synonym: "intracellular vesicle PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor signaling pathway [Term] id: GO:0002755 name: MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-dependent TLR signaling pathway" EXACT [] synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002756 name: MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149, PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-independent TLR signaling pathway" EXACT [] synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002757 name: immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] is_a: GO:0002253 ! activation of immune response is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002758 name: innate immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002757 ! immune response-activating signal transduction [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process relationship: positively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation is_a: GO:1902105 ! regulation of leukocyte differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation is_a: GO:1902106 ! negative regulation of leukocyte differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation is_a: GO:1902107 ! positive regulation of leukocyte differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002764 name: immune response-regulating signaling pathway namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002765 name: immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149] is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002766 name: innate immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149, PMID:15771571] is_a: GO:0002765 ! immune response-inhibiting signal transduction [Term] id: GO:0002767 name: immune response-inhibiting cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] is_a: GO:0002765 ! immune response-inhibiting signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002768 name: immune response-regulating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002764 ! immune response-regulating signaling pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0002769 name: natural killer cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory KIR signaling pathway" NARROW [] synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] synonym: "natural killer cell inhibitory signalling pathway" EXACT [] synonym: "NK cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002770 name: T cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] synonym: "T cell inhibitory signalling pathway" EXACT [] synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] synonym: "T-cell inhibitory signaling pathway" EXACT [] synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002771 name: inhibitory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] synonym: "KIR signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002772 name: inhibitory C-type lectin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149, PMID:15771571] synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] synonym: "Ly49 inhibitory receptor signaling pathway" RELATED [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002773 name: B cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] synonym: "B cell inhibitory signalling pathway" EXACT [] synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] synonym: "B-cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002774 name: Fc receptor mediated inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149] synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0061844 ! antimicrobial humoral immune response mediated by antimicrobial peptide [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or a tissue. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002777 name: antimicrobial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0043043 ! peptide biosynthetic process relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002778 name: antibacterial peptide production namespace: biological_process def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019731 ! antibacterial humoral response [Term] id: GO:0002779 name: antibacterial peptide secretion namespace: biological_process def: "The regulated release of an antibacterial peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002780 name: antibacterial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002781 name: antifungal peptide production namespace: biological_process def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019732 ! antifungal humoral response [Term] id: GO:0002782 name: antifungal peptide secretion namespace: biological_process def: "The regulated release of an antifungal peptide from a cell or a tissue." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002783 name: antifungal peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149, PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response relationship: regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0008348 ! negative regulation of antimicrobial humoral response relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002786 name: regulation of antibacterial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900424 ! regulation of defense response to bacterium relationship: regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002787 name: negative regulation of antibacterial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "down regulation of antibacterial peptide production" EXACT [] synonym: "down-regulation of antibacterial peptide production" EXACT [] synonym: "downregulation of antibacterial peptide production" EXACT [] synonym: "inhibition of antibacterial peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:1900425 ! negative regulation of defense response to bacterium relationship: negatively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002788 name: regulation of antifungal peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:1900150 ! regulation of defense response to fungus relationship: regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002789 name: negative regulation of antifungal peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "down regulation of antifungal peptide production" EXACT [] synonym: "down-regulation of antifungal peptide production" EXACT [] synonym: "downregulation of antifungal peptide production" EXACT [] synonym: "inhibition of antifungal peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0031348 ! negative regulation of defense response relationship: negatively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or a tissue." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion relationship: regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002797 name: regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002798 name: negative regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "down regulation of antibacterial peptide secretion" EXACT [] synonym: "down-regulation of antibacterial peptide secretion" EXACT [] synonym: "downregulation of antibacterial peptide secretion" EXACT [] synonym: "inhibition of antibacterial peptide secretion" NARROW [] is_a: GO:0002787 ! negative regulation of antibacterial peptide production is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002799 name: positive regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "activation of antibacterial peptide secretion" NARROW [] synonym: "stimulation of antibacterial peptide secretion" NARROW [] synonym: "up regulation of antibacterial peptide secretion" EXACT [] synonym: "up-regulation of antibacterial peptide secretion" EXACT [] synonym: "upregulation of antibacterial peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion is_a: GO:0002803 ! positive regulation of antibacterial peptide production relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002800 name: regulation of antifungal peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion relationship: regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002801 name: negative regulation of antifungal peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "down regulation of antifungal peptide secretion" EXACT [] synonym: "down-regulation of antifungal peptide secretion" EXACT [] synonym: "downregulation of antifungal peptide secretion" EXACT [] synonym: "inhibition of antifungal peptide secretion" NARROW [] is_a: GO:0002789 ! negative regulation of antifungal peptide production is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002802 name: positive regulation of antifungal peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "activation of antifungal peptide secretion" NARROW [] synonym: "stimulation of antifungal peptide secretion" NARROW [] synonym: "up regulation of antifungal peptide secretion" EXACT [] synonym: "up-regulation of antifungal peptide secretion" EXACT [] synonym: "upregulation of antifungal peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion is_a: GO:0002804 ! positive regulation of antifungal peptide production relationship: positively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002803 name: positive regulation of antibacterial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "activation of antibacterial peptide production" NARROW [] synonym: "stimulation of antibacterial peptide production" NARROW [] synonym: "up regulation of antibacterial peptide production" EXACT [] synonym: "up-regulation of antibacterial peptide production" EXACT [] synonym: "upregulation of antibacterial peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:1900426 ! positive regulation of defense response to bacterium relationship: positively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002804 name: positive regulation of antifungal peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "activation of antifungal peptide production" NARROW [] synonym: "stimulation of antifungal peptide production" NARROW [] synonym: "up regulation of antifungal peptide production" EXACT [] synonym: "up-regulation of antifungal peptide production" EXACT [] synonym: "upregulation of antifungal peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0031349 ! positive regulation of defense response relationship: positively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002805 name: regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0034248 ! regulation of cellular amide metabolic process relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002806 name: negative regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002807 name: positive regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0034250 ! positive regulation of cellular amide metabolic process relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002808 name: regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002809 name: negative regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] is_a: GO:0002787 ! negative regulation of antibacterial peptide production is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002810 name: regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002811 name: negative regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] is_a: GO:0002789 ! negative regulation of antifungal peptide production is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002812 name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0002813 name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002814 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002815 name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0002816 name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002817 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002818 name: intracellular defense response namespace: biological_process def: "A physiological defense response which occurs intracellularly." [GOC:add] synonym: "intracellular defence response" EXACT [] is_a: GO:0006968 ! cellular defense response is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of type 2 immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002829 name: negative regulation of type 2 immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "down regulation of type 2 immune response" EXACT [] synonym: "down-regulation of type 2 immune response" EXACT [] synonym: "downregulation of type 2 immune response" EXACT [] synonym: "inhibition of type 2 immune response" NARROW [] synonym: "negative regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "negative regulation of Th2 immune response" NARROW [GOC:add] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002830 name: positive regulation of type 2 immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a type 2 immune response." [GOC:add] synonym: "activation of type 2 immune response" NARROW [] synonym: "positive regulation of T-helper 2 type immune response" NARROW [GOC:add] synonym: "positive regulation of Th2 immune response" NARROW [GOC:add] synonym: "stimulation of type 2 immune response" NARROW [] synonym: "up regulation of type 2 immune response" EXACT [] synonym: "up-regulation of type 2 immune response" EXACT [] synonym: "upregulation of type 2 immune response" EXACT [] is_a: GO:0002828 ! regulation of type 2 immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0042092 ! type 2 immune response [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002834 name: regulation of response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "regulation of response to tumour cell" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus relationship: regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002835 name: negative regulation of response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "down regulation of response to tumor cell" EXACT [] synonym: "down-regulation of response to tumor cell" EXACT [] synonym: "downregulation of response to tumor cell" EXACT [] synonym: "inhibition of response to tumor cell" NARROW [] synonym: "negative regulation of response to tumour cell" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: negatively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002836 name: positive regulation of response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "activation of response to tumor cell" NARROW [] synonym: "positive regulation of response to tumour cell" EXACT [] synonym: "stimulation of response to tumor cell" NARROW [] synonym: "up regulation of response to tumor cell" EXACT [] synonym: "up-regulation of response to tumor cell" EXACT [] synonym: "upregulation of response to tumor cell" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell relationship: positively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002837 name: regulation of immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "regulation of immune response to tumour cell" EXACT [] is_a: GO:0002834 ! regulation of response to tumor cell is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002838 name: negative regulation of immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "down regulation of immune response to tumor cell" EXACT [] synonym: "down-regulation of immune response to tumor cell" EXACT [] synonym: "downregulation of immune response to tumor cell" EXACT [] synonym: "inhibition of immune response to tumor cell" NARROW [] synonym: "negative regulation of immune response to tumour cell" EXACT [] is_a: GO:0002835 ! negative regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002839 name: positive regulation of immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "activation of immune response to tumor cell" NARROW [] synonym: "positive regulation of immune response to tumour cell" EXACT [] synonym: "stimulation of immune response to tumor cell" NARROW [] synonym: "up regulation of immune response to tumor cell" EXACT [] synonym: "up-regulation of immune response to tumor cell" EXACT [] synonym: "upregulation of immune response to tumor cell" EXACT [] is_a: GO:0002836 ! positive regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002840 name: regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002841 name: negative regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002842 name: positive regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002843 name: regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002844 name: negative regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] synonym: "downregulation of tolerance induction to tumor cell" EXACT [] synonym: "inhibition of tolerance induction to tumor cell" NARROW [] synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002845 name: positive regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "activation of tolerance induction to tumor cell" NARROW [] synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] synonym: "stimulation of tolerance induction to tumor cell" NARROW [] synonym: "up regulation of tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] synonym: "upregulation of tolerance induction to tumor cell" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002846 name: regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002847 name: negative regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002848 name: positive regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity relationship: regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002852 name: regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002853 name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002854 name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002855 name: regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002856 name: negative regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002857 name: positive regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002858 name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002859 name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002860 name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:1904748 ! regulation of apoptotic process involved in development relationship: regulates GO:0002516 ! B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:1904746 ! negative regulation of apoptotic process involved in development relationship: negatively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:1904747 ! positive regulation of apoptotic process involved in development relationship: positively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002874 name: regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002875 name: negative regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002876 name: positive regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002877 name: regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002878 name: negative regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002879 name: positive regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002880 name: regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002881 name: negative regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002882 name: positive regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002895 name: regulation of central B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] is_a: GO:0002646 ! regulation of central tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction relationship: regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002896 name: negative regulation of central B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "down regulation of central B cell tolerance induction" EXACT [] synonym: "down-regulation of central B cell tolerance induction" EXACT [] synonym: "downregulation of central B cell tolerance induction" EXACT [] synonym: "inhibition of central B cell tolerance induction" NARROW [] is_a: GO:0002647 ! negative regulation of central tolerance induction is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002897 name: positive regulation of central B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "activation of central B cell tolerance induction" NARROW [] synonym: "stimulation of central B cell tolerance induction" NARROW [] synonym: "up regulation of central B cell tolerance induction" EXACT [] synonym: "up-regulation of central B cell tolerance induction" EXACT [] synonym: "upregulation of central B cell tolerance induction" EXACT [] is_a: GO:0002648 ! positive regulation of central tolerance induction is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction relationship: positively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002898 name: regulation of central B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002899 name: negative regulation of central B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "down regulation of central B cell deletion" EXACT [] synonym: "down-regulation of central B cell deletion" EXACT [] synonym: "downregulation of central B cell deletion" EXACT [] synonym: "inhibition of central B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002896 ! negative regulation of central B cell tolerance induction is_a: GO:0002898 ! regulation of central B cell deletion is_a: GO:0045578 ! negative regulation of B cell differentiation relationship: negatively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002900 name: positive regulation of central B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "activation of central B cell deletion" NARROW [] synonym: "stimulation of central B cell deletion" NARROW [] synonym: "up regulation of central B cell deletion" EXACT [] synonym: "up-regulation of central B cell deletion" EXACT [] synonym: "upregulation of central B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002897 ! positive regulation of central B cell tolerance induction is_a: GO:0002898 ! regulation of central B cell deletion is_a: GO:0045579 ! positive regulation of B cell differentiation relationship: positively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002901 name: mature B cell apoptotic process namespace: biological_process def: "Any apoptotic process in a B cell that is mature, having left the bone marrow." [CL:0000785, GOC:add, GOC:mtg_apoptosis, ISBN:0781735149] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell apoptosis" NARROW [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptotic process relationship: part_of GO:0001782 ! B cell homeostasis [Term] id: GO:0002902 name: regulation of B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of B cell apoptosis" NARROW [] is_a: GO:0070228 ! regulation of lymphocyte apoptotic process relationship: regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002903 name: negative regulation of B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] synonym: "negative regulation of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070229 ! negative regulation of lymphocyte apoptotic process relationship: negatively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002904 name: positive regulation of B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of B cell apoptosis" NARROW [] synonym: "positive regulation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0070230 ! positive regulation of lymphocyte apoptotic process relationship: positively_regulates GO:0001783 ! B cell apoptotic process [Term] id: GO:0002905 name: regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptotic process is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002906 name: negative regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] synonym: "negative regulation of mature B cell apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002903 ! negative regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process relationship: negatively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002907 name: positive regulation of mature B cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "positive regulation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002904 ! positive regulation of B cell apoptotic process is_a: GO:0002905 ! regulation of mature B cell apoptotic process relationship: positively_regulates GO:0002901 ! mature B cell apoptotic process [Term] id: GO:0002908 name: regulation of peripheral B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002867 ! regulation of B cell deletion relationship: regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002909 name: negative regulation of peripheral B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "down regulation of peripheral B cell deletion" EXACT [] synonym: "down-regulation of peripheral B cell deletion" EXACT [] synonym: "downregulation of peripheral B cell deletion" EXACT [] synonym: "inhibition of peripheral B cell deletion" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002910 name: positive regulation of peripheral B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "activation of peripheral B cell deletion" NARROW [] synonym: "stimulation of peripheral B cell deletion" NARROW [] synonym: "up regulation of peripheral B cell deletion" EXACT [] synonym: "up-regulation of peripheral B cell deletion" EXACT [] synonym: "upregulation of peripheral B cell deletion" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion relationship: positively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: negatively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy relationship: positively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002914 name: regulation of central B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation relationship: regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002915 name: negative regulation of central B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "down regulation of central B cell anergy" EXACT [] synonym: "down-regulation of central B cell anergy" EXACT [] synonym: "downregulation of central B cell anergy" EXACT [] synonym: "inhibition of central B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002896 ! negative regulation of central B cell tolerance induction is_a: GO:0002914 ! regulation of central B cell anergy is_a: GO:0045578 ! negative regulation of B cell differentiation relationship: negatively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002916 name: positive regulation of central B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "activation of central B cell anergy" NARROW [] synonym: "stimulation of central B cell anergy" NARROW [] synonym: "up regulation of central B cell anergy" EXACT [] synonym: "up-regulation of central B cell anergy" EXACT [] synonym: "upregulation of central B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002897 ! positive regulation of central B cell tolerance induction is_a: GO:0002914 ! regulation of central B cell anergy is_a: GO:0045579 ! positive regulation of B cell differentiation relationship: positively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002917 name: regulation of peripheral B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002712 ! regulation of B cell mediated immunity relationship: regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002918 name: negative regulation of peripheral B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "down regulation of peripheral B cell anergy" EXACT [] synonym: "down-regulation of peripheral B cell anergy" EXACT [] synonym: "downregulation of peripheral B cell anergy" EXACT [] synonym: "inhibition of peripheral B cell anergy" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002919 name: positive regulation of peripheral B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "activation of peripheral B cell anergy" NARROW [] synonym: "stimulation of peripheral B cell anergy" NARROW [] synonym: "up regulation of peripheral B cell anergy" EXACT [] synonym: "up-regulation of peripheral B cell anergy" EXACT [] synonym: "upregulation of peripheral B cell anergy" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002917 ! regulation of peripheral B cell anergy relationship: positively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0006959 ! humoral immune response [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002923 name: regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0002920 ! regulation of humoral immune response relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002924 name: negative regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002925 name: positive regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002926 name: tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridinylation namespace: biological_process def: "The process whereby a wobble base uridine residue in a tRNA is modified to 5-methoxycarbonylmethyl-2-thiouridine." [GOC:hjd, UniPathway:UPA00988] synonym: "mcm5 modification" EXACT [] synonym: "mcm5s2U34 biosynthesis" EXACT [] synonym: "tRNA wobble base 5-methoxycarbonylmethyl-2-thiouridine biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification [Term] id: GO:0002927 name: archaeosine-tRNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involved in the biosynthesis of archaeosine, an archaea-specific modified base found at position 15 in the D-loop of certain archaeal tRNAs." [GOC:hjd, UniPathway:UPA00393] comment: Archaeosine (7-formamidino-7-deazaguanosine) is a structural variant of the hypermodified nucleoside 7-deazaguanosine. The biosynthesis pathway starts with archaeosine tRNA-guanine transglycosylase (ArcTGT) which catalyzes the exchange of guanine at position 15 in the D-loop of archaeal tRNAs with a free 7-cyano-7-deazaguanine. is_a: GO:0006400 ! tRNA modification is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0002929 name: MECO complex namespace: cellular_component def: "A highly stable complex composed of the ATAC complex and the mediator complex (also called TRAP or MED). MECO binds and regulates the transcription of a subset of non-coding RNAs transcribed by RNA polymerase II." [GOC:hjd, PMID:20508642] synonym: "meta-coactivator complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0002930 name: trabecular meshwork development namespace: biological_process def: "The progression of the trabecular meshwork over time, from its formation to the mature structure. The trabecular meshwork is a fenestrated endothelial-like tissue situated at the intersection of the cornea and the iris. The trabecular meshwork provides drainage for the aqueous humor." [PMID:20568247] is_a: GO:0009888 ! tissue development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002931 name: response to ischemia namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a inadequate blood supply." [GOC:hjd] comment: Ischemia always results in hypoxia; however, hypoxia can occur without ischemia. is_a: GO:0006950 ! response to stress [Term] id: GO:0002932 name: tendon sheath development namespace: biological_process def: "The process whose specific outcome is the progression of a tendon sheath over time, from its formation to the mature structure. A tendon sheath is a layer of membrane around a tendon. It permits the tendon to move." [PMID:20696843] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0035989 ! tendon development [Term] id: GO:0002933 name: lipid hydroxylation namespace: biological_process def: "The covalent attachment of a hydroxyl group to one or more fatty acids in a lipid." [GOC:hjd, PMID:15658937] synonym: "fatty acid hydroxylation" RELATED [] is_a: GO:0030258 ! lipid modification [Term] id: GO:0002934 name: desmosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0002935 name: tRNA (adenine-C2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + adenine(37) in tRNA = S-adenosyl-L-homocysteine + 5'-deoxyadenosine + L-methionine + C2-methyladenine(37) in a tRNA." [PMID:22891362] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0002936 name: bradykinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptide hormone bradykinin." [PMID:11226291] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0002937 name: tRNA 4-thiouridine biosynthesis namespace: biological_process def: "The processes whereby a uridine residue in a tRNA is converted to 4-thiouridine. Typically 4-thiouridine is found at position 8, in many transfer RNAs." [ISBN:155581073X] comment: In E. coli, two genes are involved, nuvA (aka Thi) and NuvC (aka iscS) . NuvA converts the trNA into an unidentified intermediate in an ATP dependent manner. NucC catalyzes the second step, transferring the sulfur from cysteine to an unidentified intermediate. NuvC also participates in thiamine synthesis. is_a: GO:0034227 ! tRNA thio-modification [Term] id: GO:0002938 name: tRNA guanine ribose methylation namespace: biological_process def: "The process whereby a guanosine residue in a tRNA is methylated on the 2'-hydroxyl group of the ribose moiety." [ISBN:155581075X, ISBN:1555811337] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002939 name: tRNA N1-guanine methylation namespace: biological_process def: "The process whereby a guanine in tRNA is methylated at position N1 of the guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m1-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002940 name: tRNA N2-guanine methylation namespace: biological_process def: "The process whereby a guanine in a tRNA is methylated at the N2 position of guanine." [ISBN:155581073X, ISBN:1555811337] synonym: "tRNA m2-guanine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002941 name: synoviocyte proliferation namespace: biological_process def: "The multiplication or reproduction of synoviocytes by cell division, resulting in the expansion of their population. A synoviocyte is a fibroblast-like cell found in synovial tissues." [CL:0000214, PMID:9546370] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0002942 name: tRNA m2,2-guanine biosynthesis namespace: biological_process def: "The process whereby a guanine residue in a transfer RNA is methylated twice at the N2 position." [GOC:hjd, ISBN:1-55581-073-x] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002943 name: tRNA dihydrouridine synthesis namespace: biological_process def: "The process whereby a uridine in a transfer RNA is converted to dihydrouridine." [GOC:hjd, ISBN:1-55581-073-x] comment: Dihydrouridine is found in numerous positions within loop I, the so-called dihydrouridine loop, of many transfer RNAs. Most often found at positions 16 and 17, but also sometimes at positions 20, 20a, and 20b. is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002944 name: cyclin K-CDK12 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 12 (CDK12). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk12 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0002945 name: cyclin K-CDK13 complex namespace: cellular_component def: "A protein complex consisting of cyclin Kand cyclin-dependent kinase 13 (CDK13). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner." [PMID:22012619] synonym: "CycK/Cdk13 complex" RELATED [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0002946 name: tRNA C5-cytosine methylation namespace: biological_process def: "The process whereby a cytosine in a tRNA is methylated at position 5 of the cytosine." [ISBN:1-55581-073-x] synonym: "tRNA 5-methylcytosine biosynthesis" RELATED [] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002947 name: tumor necrosis factor receptor superfamily complex namespace: cellular_component def: "A receptor complex that contains one or more members of the tumor necrosis factor (TNF) receptor superfamily." [GOC:krc] synonym: "TNF receptor superfamily complex" RELATED [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002948 name: archaeosine synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + 7-cyano-7-carbaguanine15 in tRNA + H2O = L-glutamate + archaeine15 in tRNA." [PMID:20129918, Wikipedia:Archaeosine_synthase] synonym: "ArcS" RELATED [] synonym: "glutamine:preQ0-tRNA amidinotransferase" RELATED [] xref: EC:2.6.1.97 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0002949 name: tRNA threonylcarbamoyladenosine modification namespace: biological_process alt_id: GO:0070526 def: "The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base)." [GO:0070526, GOC:imk, GOC:mah, PMID:19287007, PMID:21183954, PMID:23258706] synonym: "t6A biosynthesis" EXACT [PMID:19287007] synonym: "t6A biosynthetic process" EXACT [PMID:19287007] synonym: "t6A tRNA modification" EXACT [] synonym: "threonylcarbamoyladenosine anabolism" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine biosynthesis" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine biosynthetic process" EXACT [] synonym: "threonylcarbamoyladenosine formation" EXACT [GOC:mah] synonym: "threonylcarbamoyladenosine synthesis" EXACT [GOC:mah] is_a: GO:0006400 ! tRNA modification is_a: GO:0070525 ! tRNA threonylcarbamoyladenosine metabolic process [Term] id: GO:0002950 name: ceramide phosphoethanolamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + a ceramide = CMP + a ceramide phosphoethanolamine." [EC:2.7.8.n3, PMID:25667419] xref: reactome:R-HSA-8959462 "SAMD8 transforms PE and CERA to CPE" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0002951 name: leukotriene-C(4) hydrolase namespace: molecular_function def: "Catalysis of the reaction Leukotriene C(4) + H(2)O= leukotriene D(4) + L-glutamate." [EC:3.4.19.14, PMID:9774450] comment: The mouse enzyme is specific for leukotriene C(4), while the human enzyme also has considerable activity toward glutathione and oxidized glutathione (cf. EC:3.4.19.13). PMID:9774450 cites that the mouse form of this enzyme failed to measure activity towards glutathione. is_a: GO:0070122 ! isopeptidase activity [Term] id: GO:0002952 name: (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione isomerase activity namespace: molecular_function def: "Catalysis of the reaction (4S)-4-hydroxy-5-phosphonooxypentane-2,3-dione = 3-hydroxy-5-phosphonooxypentane-2,4-dione." [EC:5.3.1.32] synonym: "phospho-AI-2 isomerase activity" RELATED [] is_a: GO:0016853 ! isomerase activity [Term] id: GO:0002953 name: 5'-deoxynucleotidase activity namespace: molecular_function def: "Catalysis of the reaction:a 2'-deoxyribonucleoside 5'-monophosphate + H20=a 2'-deoxyribonucleoside + phosphate." [EC:3.1.3.89] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003001 name: obsolete generation of a signal involved in cell-cell signaling namespace: biological_process def: "The cellular process that creates a physical entity or change in state, i.e. a signal, that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] comment: This term was made obsolete because biosynthesis of a signal occurs before the start of cell-cell signaling. synonym: "formation of a signal" BROAD [] synonym: "generation of a signal involved in cell-cell signaling" EXACT [] synonym: "generation of a signal involved in cell-cell signalling" EXACT [] synonym: "signal generation" BROAD [] is_obsolete: true consider: GO:0007267 consider: GO:0010496 consider: GO:0023061 consider: GO:0031130 [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003003 name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage namespace: biological_process def: "The ovulation cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0003004 name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048164 ! distinct antral spaces stage [Term] id: GO:0003005 name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage namespace: biological_process def: "The menstrual cycle process in which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048163 ! scattered antral spaces stage [Term] id: GO:0003006 name: developmental process involved in reproduction namespace: biological_process def: "A developmental process in which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] synonym: "puberty" NARROW [GOC:dph] synonym: "reproductive developmental process" RELATED [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process in which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003010 name: voluntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003011 name: involuntary skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] subset: goslim_chembl subset: goslim_generic xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system maintains fluid balance, and contributes to electrolyte balance, acid/base balance, and disposal of nitrogenous waste products. In humans, the renal system comprises a pair of kidneys, a pair of ureters, urinary bladder, urethra, sphincter muscle and associated blood vessels; in other species, the renal system may comprise related structures (e.g., nephrocytes and malpighian tubules in Drosophila)." [GOC:cjm, GOC:mtg_cardio, GOC:mtg_kidney_jan10] synonym: "excretory system process" EXACT [] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "respiratory gaseous exchange by respiratory system" EXACT [] is_a: GO:0003008 ! system process is_a: GO:0007585 ! respiratory gaseous exchange [Term] id: GO:0003017 name: lymph circulation namespace: biological_process def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003019 name: central nervous system control of baroreceptor feedback namespace: biological_process def: "The neurological process in which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0003020 name: detection of reduced oxygen by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0070483 ! detection of hypoxia relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003021 name: detection of increased carbon dioxide by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003022 name: detection of pH by chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors." [GOC:mtg_cardio, ISBN:0323031951] synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003030 ! detection of hydrogen ion [Term] id: GO:0003023 name: baroreceptor detection of increased arterial stretch namespace: biological_process def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0003024 name: baroreceptor detection of decreased arterial stretch namespace: biological_process def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0003025 name: regulation of systemic arterial blood pressure by baroreceptor feedback namespace: biological_process def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003026 name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0003027 name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] synonym: "vagal reflex" BROAD [] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003028 name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003029 name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003030 name: detection of hydrogen ion namespace: biological_process def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003031 name: detection of carbon dioxide namespace: biological_process def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003033 name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003034 name: detection of increased carbon dioxide by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003035 name: detection of increased carbon dioxide by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of carbon dioxide are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003036 name: detection of pH by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003037 name: detection of pH by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003038 name: detection of reduced oxygen by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003039 name: detection of reduced oxygen by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003040 name: excitation of vasomotor center by aortic body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003041 name: excitation of vasomotor center by carotid body chemoreceptor signaling namespace: biological_process def: "The process in which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003042 name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951] synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003043 name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003045 name: regulation of systemic arterial blood pressure by physical factors namespace: biological_process def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by physical factors" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003046 name: regulation of systemic arterial blood pressure by stress relaxation namespace: biological_process def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by stress relaxation" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003047 name: regulation of systemic arterial blood pressure by epinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by epinephrine" RELATED [] synonym: "regulation of blood pressure by adrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003048 name: regulation of systemic arterial blood pressure by norepinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by norepinephrine" RELATED [] synonym: "regulation of blood pressure by noradrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003049 name: regulation of systemic arterial blood pressure by capillary fluid shift namespace: biological_process def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure regulation by capillary fluid shift" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors [Term] id: GO:0003050 name: regulation of systemic arterial blood pressure by atrial natriuretic peptide namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003051 name: angiotensin-mediated drinking behavior namespace: biological_process def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] is_a: GO:0042756 ! drinking behavior relationship: part_of GO:0002035 ! brain renin-angiotensin system [Term] id: GO:0003052 name: circadian regulation of systemic arterial blood pressure namespace: biological_process def: "Any process in which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003053 name: circadian regulation of heart rate namespace: biological_process def: "Any process in which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate" RELATED [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0007623 ! circadian rhythm is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003054 name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "master pacemaker clock regulation of blood pressure" EXACT [] synonym: "SCN regulation of blood pressure" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003055 name: circadian regulation of heart rate by the suprachiasmatic nucleus namespace: biological_process def: "The process in which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] synonym: "master pacemaker clock regulation of heart rate" EXACT [] synonym: "SCN regulation of heart rate" EXACT [] is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 name: regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction relationship: regulates GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0003057 name: regulation of the force of heart contraction by chemical signal namespace: biological_process def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] synonym: "chemical cardiac inotropy" EXACT [] synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0003058 name: hormonal regulation of the force of heart contraction namespace: biological_process def: "The process in which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac inotropy" EXACT [] synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal [Term] id: GO:0003059 name: positive regulation of the force of heart contraction by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac inotropy" EXACT [] synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac inotropy" EXACT [] synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003060 name: negative regulation of the force of heart contraction by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "decreased force of heart contraction by acetylcholine" EXACT [] is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003061 name: positive regulation of the force of heart contraction by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] synonym: "increased force of heart contraction by adrenaline" RELATED [] synonym: "increased force of heart contraction by norepinephrine" EXACT [] synonym: "noradrenaline cardiac inotropy" EXACT [] synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac inotropy" EXACT [] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003062 name: regulation of heart rate by chemical signal namespace: biological_process def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] synonym: "chemical cardiac chronotropy" EXACT [] synonym: "chemical signal regulation of heart contraction rate" RELATED [] synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate [Term] id: GO:0003063 name: negative regulation of heart rate by acetylcholine namespace: biological_process def: "The process in which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003064 name: regulation of heart rate by hormone namespace: biological_process def: "The process in which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac chronotropy" EXACT [] synonym: "regulation of the rate of heart contraction by hormone" EXACT [GOC:curators] is_a: GO:0003062 ! regulation of heart rate by chemical signal [Term] id: GO:0003065 name: positive regulation of heart rate by epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac chronotropy" EXACT [] synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003066 name: positive regulation of heart rate by norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "noradrenaline cardiac chronotropy" EXACT [] synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003067 name: circadian regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process in which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003068 name: regulation of systemic arterial blood pressure by acetylcholine namespace: biological_process def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] synonym: "blood pressure regulation by acetylcholine" EXACT [] is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter [Term] id: GO:0003069 name: acetylcholine-mediated vasodilation involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process in which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] synonym: "vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003070 name: regulation of systemic arterial blood pressure by neurotransmitter namespace: biological_process def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003072 name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003074 name: obsolete regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035809 [Term] id: GO:0003075 name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [Term] id: GO:0003077 name: obsolete negative regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "negative regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035811 [Term] id: GO:0003078 name: obsolete regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. synonym: "regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035813 [Term] id: GO:0003079 name: obsolete positive regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035815 [Term] id: GO:0003080 name: obsolete negative regulation of natriuresis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] comment: This term was made obsolete because its definition was inaccurate. synonym: "negative regulation of natriuresis" EXACT [] is_obsolete: true consider: GO:0035814 [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process in which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003082 name: obsolete positive regulation of renal output by angiotensin namespace: biological_process def: "OBSOLETE. Any process in which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of renal output by angiotensin" EXACT [] is_obsolete: true [Term] id: GO:0003083 name: negative regulation of renal output by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0003084 name: positive regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045777 ! positive regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003085 name: negative regulation of systemic arterial blood pressure namespace: biological_process def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045776 ! negative regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003086 name: regulation of systemic arterial blood pressure by local renal renin-angiotensin namespace: biological_process def: "The process in which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0003087 name: positive regulation of the force of heart contraction by neuronal epinephrine namespace: biological_process def: "The process in which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine [Term] id: GO:0003088 name: positive regulation of the force of heart contraction by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine [Term] id: GO:0003089 name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003090 name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of an internal steady state of water in the body." [GOC:mtg_cardio] synonym: "water homeostasis by the kidney" EXACT [] is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0003092 name: renal water retention namespace: biological_process def: "The process in which renal water excretion is decreased." [GOC:mtg_cardio] synonym: "negative regulation of renal water excretion" EXACT [] is_a: GO:0035811 ! negative regulation of urine volume [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process in which blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0098801 ! regulation of renal system process relationship: regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process in which plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, GOC:sart, ISBN:0721643949] is_a: GO:0097205 ! renal filtration [Term] id: GO:0003095 name: pressure natriuresis namespace: biological_process def: "The process in which the volume of blood increases renal pressure and thereby results in both an increase in urine volume (diuresis) and an increase in the amount of sodium excreted in the urine (natriuresis)." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport relationship: part_of GO:0003091 ! renal water homeostasis [Term] id: GO:0003098 name: tubuloglomerular feedback namespace: biological_process def: "The process in which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] xref: Wikipedia:Tubuloglomerular_feedback is_a: GO:0001977 ! renal system process involved in regulation of blood volume relationship: part_of GO:0003093 ! regulation of glomerular filtration [Term] id: GO:0003099 name: positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0003100 name: regulation of systemic arterial blood pressure by endothelin namespace: biological_process def: "The process in which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003101 name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine namespace: biological_process def: "The process in which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003102 name: obsolete positive regulation of diuresis by angiotensin namespace: biological_process def: "OBSOLETE. Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of diuresis by angiotensin" EXACT [] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003103 name: obsolete positive regulation of diuresis namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of diuresis" EXACT [] is_obsolete: true consider: GO:0035810 [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003106 name: negative regulation of glomerular filtration by angiotensin namespace: biological_process def: "The process in which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] synonym: "angiotensin-mediated regulation of glomerular filtration" BROAD [GOC:dph, GOC:tb] synonym: "regulation of glomerular filtration by angiotensin" BROAD [] is_a: GO:0003083 ! negative regulation of renal output by angiotensin relationship: part_of GO:0003105 ! negative regulation of glomerular filtration [Term] id: GO:0003107 name: obsolete positive regulation of natriuresis by angiotensin namespace: biological_process def: "OBSOLETE. The process in which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] comment: This term was made obsolete because the term is misleading. synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of natriuresis by angiotensin" EXACT [] is_obsolete: true [Term] id: GO:0003108 name: negative regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0003109 name: positive regulation of the force of heart contraction by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003110 name: positive regulation of the force of heart contraction by neuronal norepinephrine namespace: biological_process def: "The process in which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003111 name: positive regulation of heart rate by circulating epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003112 name: positive regulation of heart rate by neuronal epinephrine namespace: biological_process def: "The process in which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003113 name: positive regulation of heart rate by neuronal norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003114 name: positive regulation of heart rate by circulating norepinephrine namespace: biological_process def: "The process in which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003115 name: regulation of vasoconstriction by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003116 name: regulation of vasoconstriction by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003117 name: regulation of vasoconstriction by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003118 name: regulation of vasoconstriction by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003119 name: regulation of vasoconstriction by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003120 name: regulation of vasoconstriction by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003121 name: epinephrine-mediated vasodilation namespace: biological_process alt_id: GO:0003123 alt_id: GO:0003124 def: "A vasodilation process resulting from secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by adrenaline" RELATED [] synonym: "regulation of vasodilation by circulating adrenaline" RELATED [] synonym: "regulation of vasodilation by circulating epinephrine" RELATED [] synonym: "regulation of vasodilation by epinephrine" RELATED [] synonym: "regulation of vasodilation by neuronal adrenaline" RELATED [] synonym: "regulation of vasodilation by neuronal epinephrine" RELATED [] is_a: GO:0042311 ! vasodilation [Term] id: GO:0003122 name: norepinephrine-mediated vasodilation namespace: biological_process alt_id: GO:0003125 alt_id: GO:0003126 def: "A vasodilation process resulting from secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating noradrenaline" RELATED [] synonym: "regulation of vasodilation by circulating norepinephrine" RELATED [] synonym: "regulation of vasodilation by neuronal noradrenaline" RELATED [] synonym: "regulation of vasodilation by neuronal norepinephrine" RELATED [] synonym: "regulation of vasodilation by noradrenaline" RELATED [] synonym: "regulation of vasodilation by norepinephrine" RELATED [] is_a: GO:0042311 ! vasodilation [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry [Term] id: GO:0003128 name: heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area in which the heart will develop." [GOC:mtg_heart] is_a: GO:0010092 ! specification of animal organ identity relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003129 name: heart induction namespace: biological_process def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] is_a: GO:0001759 ! organ induction is_a: GO:2000826 ! regulation of heart morphogenesis relationship: positively_regulates GO:0003128 ! heart field specification [Term] id: GO:0003130 name: BMP signaling pathway involved in heart induction namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to heart induction." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003132 name: mesodermal-endodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "mesodermal-endodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003131 ! mesodermal-endodermal cell signaling relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling [Term] id: GO:0003134 name: endodermal-mesodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] synonym: "endodermal-mesodermal cell signalling involved in heart induction" EXACT [GOC:mah] is_a: GO:0003133 ! endodermal-mesodermal cell signaling relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003135 name: fibroblast growth factor receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003136 name: negative regulation of heart induction by canonical Wnt signaling pathway namespace: biological_process def: "Any canonical Wnt signaling that decreases the rate, frequency or extent of heart induction." [GOC:mtg_heart, PMID:19862329] synonym: "negative regulation of cardioblast cell fate specification by Wnt receptor signaling pathway" EXACT [GOC:dph] synonym: "negative regulation of heart induction by canonical Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of heart induction by canonical Wnt receptor signalling pathway" EXACT [GOC:mah] synonym: "negative regulation of heart induction by canonical Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009997 ! negative regulation of cardioblast cell fate specification is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development is_a: GO:0100012 ! regulation of heart induction by canonical Wnt signaling pathway is_a: GO:1901320 ! negative regulation of heart induction [Term] id: GO:0003137 name: Notch signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] synonym: "Notch signalling pathway involved in heart induction" EXACT [GOC:mah] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0003129 ! heart induction [Term] id: GO:0003138 name: primary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the primary beating heart tube. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "FHS specification" EXACT [GOC:rl] synonym: "first heart field specification" EXACT [GOC:rl] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003139 name: secondary heart field specification namespace: biological_process def: "The process that results in the delineation of a specific region of the lateral mesoderm into the area which will form the majority of the mesodermal component of the right ventricle, arterial pole (outflow tract) and venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] synonym: "second heart field specification" EXACT [GOC:mtg_heart, PMID:17276708] synonym: "SHF specification" EXACT [GOC:rl, PMID:22449840] is_a: GO:0003128 ! heart field specification [Term] id: GO:0003140 name: determination of left/right asymmetry in lateral mesoderm namespace: biological_process def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048368 ! lateral mesoderm development [Term] id: GO:0003141 name: obsolete transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "OBSOLETE. The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] comment: This term was made obsolete because it describes involvement of the nodal signaling pathway in lateral mesoderm left/right asymmetry. Nodal proteins are members of the TGF-beta superfamily, but are distinct from TGF-beta proteins themselves. TGF-beta proteins are not currently known to regulate left/right asymmetry in the lateral mesoderm. synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_obsolete: true replaced_by: GO:1900164 [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic heart tube are generated and organized. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development relationship: part_of GO:0048562 ! embryonic organ morphogenesis [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation [Term] id: GO:0003146 name: heart jogging namespace: biological_process def: "The morphogenetic process in which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] synonym: "cardiac jogging" EXACT [GOC:mtg_heart] is_a: GO:0003143 ! embryonic heart tube morphogenesis relationship: part_of GO:0061371 ! determination of heart left/right asymmetry [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube towards the heart and that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0061308 ! cardiac neural crest cell development involved in heart development [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract septum are generated and organized. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process in which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process in which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0060415 ! muscle tissue morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the outflow tract are generated and organized. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart, UBERON:0004145] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process in which an epithelial sheet bends along a linear axis, contributing to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003153 name: closure of embryonic heart tube namespace: biological_process def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] is_a: GO:0060606 ! tube closure relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the determination of left/right symmetry." [GOC:mtg_heart, GOC:signaling] synonym: "BMP signaling pathway involved in determination of left/right asymmetry" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in determination of left/right symmetry" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway is_a: GO:1900094 ! regulation of transcription from RNA polymerase II promoter involved in determination of left/right symmetry [Term] id: GO:0003155 name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "BMP signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm [Term] id: GO:0003156 name: regulation of animal organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of animal organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: regulates GO:0048645 ! animal organ formation [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process in which the anatomical structure of an endothelium is generated and organized. Endothelium refers to the layer of cells lining blood vessels, lymphatics, the heart, and serous cavities, and is derived from bone marrow or mesoderm. Corneal endothelium is a special case, derived from neural crest cells." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0003158 ! endothelium development [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003157 ! endocardium development [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] synonym: "SAN development" EXACT [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "sinus node development" NARROW [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] is_a: GO:0048738 ! cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003161 ! cardiac conduction system development [Term] id: GO:0003165 name: Purkinje myocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a Purkinje myocyte over time, from its formation to the mature structure. The Purkinje myocyte (also known as cardiac Purkinje fiber) is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber development" EXACT [] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0003229 ! ventricular cardiac muscle tissue development relationship: part_of GO:0003164 ! His-Purkinje system development [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003166 ! bundle of His development [Term] id: GO:0003168 name: Purkinje myocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a Purkinje myocyte (also known as cardiac Purkinje fiber cell). These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] synonym: "cardiac Purkinje fiber cell differentiation" EXACT [] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003165 ! Purkinje myocyte development [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process in which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003171 name: atrioventricular valve development namespace: biological_process def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "AV valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003172 name: sinoatrial valve development namespace: biological_process def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "SA valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003173 name: ventriculo bulbo valve development namespace: biological_process def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003174 name: mitral valve development namespace: biological_process def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003171 ! atrioventricular valve development [Term] id: GO:0003175 name: tricuspid valve development namespace: biological_process def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003171 ! atrioventricular valve development [Term] id: GO:0003176 name: aortic valve development namespace: biological_process def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:1905314 ! semi-lunar valve development [Term] id: GO:0003177 name: pulmonary valve development namespace: biological_process def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:1905314 ! semi-lunar valve development [Term] id: GO:0003178 name: coronary sinus valve development namespace: biological_process def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process in which the structure of a heart valve is generated and organized." [GOC:mtg_heart] synonym: "heart valve remodeling" NARROW [GOC:vk, GOC:yaf] synonym: "heart valve remodelling" NARROW [GOC:vk, GOC:yaf] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003180 name: aortic valve morphogenesis namespace: biological_process def: "The process in which the structure of the aortic valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003176 ! aortic valve development [Term] id: GO:0003181 name: atrioventricular valve morphogenesis namespace: biological_process def: "The process in which the structure of the atrioventricular valve is generated and organized." [GOC:mtg_heart] synonym: "AV valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003171 ! atrioventricular valve development [Term] id: GO:0003182 name: coronary sinus valve morphogenesis namespace: biological_process def: "The process in which the structure of the coronary sinus valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003178 ! coronary sinus valve development [Term] id: GO:0003183 name: mitral valve morphogenesis namespace: biological_process def: "The process in which the structure of the mitral valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003181 ! atrioventricular valve morphogenesis relationship: part_of GO:0003174 ! mitral valve development [Term] id: GO:0003184 name: pulmonary valve morphogenesis namespace: biological_process def: "The process in which the structure of the pulmonary valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003177 ! pulmonary valve development [Term] id: GO:0003185 name: sinoatrial valve morphogenesis namespace: biological_process def: "The process in which the structure of the sinoatrial valve is generated and organized." [GOC:mtg_heart] synonym: "SA valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003172 ! sinoatrial valve development [Term] id: GO:0003186 name: tricuspid valve morphogenesis namespace: biological_process def: "The process in which the structure of the tricuspid valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003181 ! atrioventricular valve morphogenesis relationship: part_of GO:0003175 ! tricuspid valve development [Term] id: GO:0003187 name: ventriculo bulbo valve morphogenesis namespace: biological_process def: "The process in which the structure of the ventriculo bulbo valve is generated and organized." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003173 ! ventriculo bulbo valve development [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003189 name: aortic valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003180 ! aortic valve morphogenesis [Term] id: GO:0003190 name: atrioventricular valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "AV valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis [Term] id: GO:0003191 name: coronary sinus valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis [Term] id: GO:0003192 name: mitral valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003190 ! atrioventricular valve formation relationship: part_of GO:0003183 ! mitral valve morphogenesis [Term] id: GO:0003193 name: pulmonary valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003184 ! pulmonary valve morphogenesis [Term] id: GO:0003194 name: sinoatrial valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "SA valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis [Term] id: GO:0003195 name: tricuspid valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003190 ! atrioventricular valve formation relationship: part_of GO:0003186 ! tricuspid valve morphogenesis [Term] id: GO:0003196 name: ventriculo bulbo valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003198 name: epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003199 name: endocardial cushion to mesenchymal transition involved in heart valve formation namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] synonym: "endocardial cushion to mesenchymal transition involved in valve formation" EXACT [GOC:bf] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0003188 ! heart valve formation [Term] id: GO:0003200 name: endocardial cushion to mesenchymal transition involved in heart chamber septation namespace: biological_process def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0060411 ! cardiac septum morphogenesis [Term] id: GO:0003201 name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060977 ! coronary vasculature morphogenesis [Term] id: GO:0003202 name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] is_a: GO:0090500 ! endocardial cushion to mesenchymal transition relationship: part_of GO:0003204 ! cardiac skeleton development [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process in which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process in which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process in which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process in which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process in which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process in which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process in which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003222 name: ventricular trabecula myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "trabecula carnea morphogenesis" RELATED [GOC:dph] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis is_a: GO:0061384 ! heart trabecula morphogenesis [Term] id: GO:0003223 name: ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis [Term] id: GO:0003224 name: left ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis [Term] id: GO:0003226 name: right ventricular compact myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecula myocardium morphogenesis [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003232 name: bulbus arteriosus development namespace: biological_process def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003233 name: bulbus arteriosus morphogenesis namespace: biological_process def: "The process in which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003232 ! bulbus arteriosus development [Term] id: GO:0003234 name: bulbus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process in which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003235 ! sinus venosus development [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003236 ! sinus venosus morphogenesis [Term] id: GO:0003238 name: conus arteriosus development namespace: biological_process def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development [Term] id: GO:0003239 name: conus arteriosus morphogenesis namespace: biological_process def: "The process in which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003238 ! conus arteriosus development [Term] id: GO:0003240 name: conus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003239 ! conus arteriosus morphogenesis [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth [Term] id: GO:0003242 name: cardiac chamber ballooning namespace: biological_process def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis [Term] id: GO:0003243 name: circumferential growth involved in left ventricle morphogenesis namespace: biological_process def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis [Term] id: GO:0003244 name: radial growth involved in right ventricle morphogenesis namespace: biological_process def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis [Term] id: GO:0003246 name: embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003247 name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis is_a: GO:2000793 ! cell proliferation involved in heart valve development relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000138 ! positive regulation of cell proliferation involved in heart morphogenesis relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:2000137 ! negative regulation of cell proliferation involved in heart morphogenesis relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0061309 ! cardiac neural crest cell development involved in outflow tract morphogenesis [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential is_a: GO:0050794 ! regulation of cellular process is_a: GO:0050801 ! ion homeostasis relationship: regulates GO:0051899 ! membrane depolarization [Term] id: GO:0003255 name: endocardial precursor cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation [Term] id: GO:0003256 name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation [Term] id: GO:0003257 name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation is_a: GO:1901228 ! positive regulation of transcription from RNA polymerase II promoter involved in heart development [Term] id: GO:0003258 name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] is_a: GO:1901213 ! regulation of transcription from RNA polymerase II promoter involved in heart development relationship: part_of GO:0003255 ! endocardial precursor cell differentiation [Term] id: GO:0003259 name: cardioblast anterior-lateral migration namespace: biological_process def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation [Term] id: GO:0003261 name: cardiac muscle progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003262 name: endocardial progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation [Term] id: GO:0003263 name: cardioblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0060914 ! heart formation [Term] id: GO:0003264 name: regulation of cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003156 ! regulation of animal organ formation is_a: GO:2000136 ! regulation of cell proliferation involved in heart morphogenesis relationship: regulates GO:0003263 ! cardioblast proliferation [Term] id: GO:0003265 name: regulation of primary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the primary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. In mammals the primary heart field gives rise to the left ventricle." [GOC:mtg_heart, GOC:rl] synonym: "regulation of FHF cardioblast proliferation" EXACT [GOC:rl] synonym: "regulation of first heart field cardiac proliferation" RELATED [] synonym: "regulation of first heart field cardioblast proliferation" EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003266 name: regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating. The secondary heart field is the region of the heart that will form the majority of the mesodermal component of the right ventricle, the arterial pole (outflow tract) and the venous pole (inflow tract)." [GOC:mtg_heart, GOC:rl, PMID:17276708] synonym: "regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "regulation of SHF cardioblast proliferation" EXACT [GOC:rl] is_a: GO:0003264 ! regulation of cardioblast proliferation [Term] id: GO:0003267 name: canonical Wnt signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A canonical Wnt signaling pathway that contributes to an increase in the frequency, or rate of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "canonical Wnt receptor signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [] synonym: "canonical Wnt receptor signalling pathway involved in positive regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] synonym: "canonical Wnt-activated signaling pathway involved in positive regulation of secondary heart field cardioblast proliferation" RELATED [GOC:signaling] is_a: GO:0044340 ! canonical Wnt signaling pathway involved in regulation of cell proliferation is_a: GO:0061316 ! canonical Wnt signaling pathway involved in heart development relationship: part_of GO:0072513 ! positive regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003268 name: fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of second heart field cardioblast cell proliferation" EXACT [GOC:dph] synonym: "fibroblast growth factor receptor signaling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:bf] synonym: "fibroblast growth factor receptor signalling pathway involved in regulation of secondary heart field cardioblast cell proliferation" EXACT [GOC:mah] is_a: GO:0061313 ! fibroblast growth factor receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003269 name: BMP signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "BMP signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003270 name: Notch signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "Notch signaling pathway involved in regulation of second heart field cardioblast proliferation" RELATED [GOC:dph] synonym: "Notch signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0061314 ! Notch signaling involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003271 name: smoothened signaling pathway involved in regulation of secondary heart field cardioblast proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened contributing to the modulation of the frequency, rate or extent of cardioblast proliferation in the secondary heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "hedgehog signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened receptor signaling pathway involved in regulation of second heart field cardioblast proliferation" EXACT [GOC:dph] synonym: "smoothened receptor signaling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:bf] synonym: "smoothened receptor signalling pathway involved in regulation of secondary heart field cardioblast proliferation" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development relationship: part_of GO:0003266 ! regulation of secondary heart field cardioblast proliferation [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003272 ! endocardial cushion formation [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0061343 ! cell adhesion involved in heart morphogenesis is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003275 name: apoptotic process involved in outflow tract morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in outflow tract morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis [Term] id: GO:0003276 name: apoptotic process involved in heart valve morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of a heart valve." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart valve morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis [Term] id: GO:0003277 name: apoptotic process involved in endocardial cushion morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in endocardial cushion morphogenesis" NARROW [] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis [Term] id: GO:0003278 name: apoptotic process involved in heart morphogenesis namespace: biological_process def: "Any apoptotic process that contributes to the shaping of the heart." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in heart morphogenesis" NARROW [] is_a: GO:0060561 ! apoptotic process involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003205 ! cardiac chamber development [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003231 ! cardiac ventricle development [Term] id: GO:0003282 name: ventricular septum intermedium development namespace: biological_process def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003281 ! ventricular septum development [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003230 ! cardiac atrium development [Term] id: GO:0003284 name: septum primum development namespace: biological_process def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003285 name: septum secundum development namespace: biological_process def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003286 name: atrial septum intermedium development namespace: biological_process def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development [Term] id: GO:0003288 name: ventricular septum intermedium morphogenesis namespace: biological_process def: "The developmental process in which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060412 ! ventricular septum morphogenesis [Term] id: GO:0003289 name: atrial septum primum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003284 ! septum primum development [Term] id: GO:0003290 name: atrial septum secundum morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003285 ! septum secundum development [Term] id: GO:0003291 name: atrial septum intermedium morphogenesis namespace: biological_process def: "The process in which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003286 ! atrial septum intermedium development [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003279 ! cardiac septum development [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process in which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiocyte differentiation relationship: part_of GO:0003170 ! heart valve development [Term] id: GO:0003294 name: atrial ventricular junction remodeling namespace: biological_process def: "The reorganization or renovation of heart tissue that contributes to the maturation of the connection between an atrium and a ventricle." [GOC:mtg_heart] synonym: "atrio-ventricular junction remodeling" RELATED [GOC:mtg_heart] synonym: "atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003295 name: cell proliferation involved in atrial ventricular junction remodeling namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "cell proliferation involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0061323 ! cell proliferation involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003296 name: apoptotic process involved in atrial ventricular junction remodeling namespace: biological_process def: "Any apoptotic process that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_apoptosis, GOC:mtg_heart] synonym: "apoptosis involved in atrial ventricular junction remodeling" NARROW [] synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "apoptosis involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0003278 ! apoptotic process involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling [Term] id: GO:0003297 name: heart wedging namespace: biological_process def: "The morphogenetic process in which the aorta inserts between the atrioventricular valves, contributing to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0003299 name: muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] is_a: GO:0006950 ! response to stress is_a: GO:0014896 ! muscle hypertrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_heart] is_a: GO:0003298 ! physiological muscle hypertrophy is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth [Term] id: GO:0003302 name: transforming growth factor beta receptor signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart, GOC:signaling] synonym: "transforming growth factor beta receptor signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry is_a: GO:1905313 ! transforming growth factor beta receptor signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003303 name: BMP signaling pathway involved in heart jogging namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "BMP signalling pathway involved in heart jogging" EXACT [GOC:mah] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry is_a: GO:0061312 ! BMP signaling pathway involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003304 name: myocardial epithelial involution involved in heart jogging namespace: biological_process def: "The morphogenetic process in which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003305 name: cell migration involved in heart jogging namespace: biological_process def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003146 ! heart jogging [Term] id: GO:0003306 name: Wnt signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0061311 ! cell surface receptor signaling pathway involved in heart development [Term] id: GO:0003307 name: regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0030111 ! regulation of Wnt signaling pathway is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0003306 ! Wnt signaling pathway involved in heart development [Term] id: GO:0003308 name: negative regulation of Wnt signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] synonym: "negative regulation of Wnt receptor signaling pathway involved in heart development" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway involved in heart development" EXACT [GOC:mah] synonym: "negative regulation of Wnt-activated signaling pathway involved in heart development" EXACT [GOC:signaling] is_a: GO:0003307 ! regulation of Wnt signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt signaling pathway is_a: GO:0051093 ! negative regulation of developmental process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0003306 ! Wnt signaling pathway involved in heart development [Term] id: GO:0003309 name: type B pancreatic cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph, PMID:11076772] synonym: "pancreatic B cell differentiation" EXACT [GOC:mah] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0035883 ! enteroendocrine cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0035050 ! embryonic heart tube development [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0003313 ! heart rudiment development [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003314 ! heart rudiment morphogenesis [Term] id: GO:0003316 name: establishment of myocardial progenitor cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003317 name: cardioblast cell midline fusion namespace: biological_process def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] is_a: GO:0034109 ! homotypic cell-cell adhesion relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003318 name: cell migration to the midline involved in heart development namespace: biological_process def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003319 name: cardioblast migration to the midline involved in heart rudiment formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0003315 ! heart rudiment formation [Term] id: GO:0003320 name: heart rudiment involution namespace: biological_process def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation [Term] id: GO:0003321 name: positive regulation of blood pressure by epinephrine-norepinephrine namespace: biological_process def: "Any process in which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine is_a: GO:0045777 ! positive regulation of blood pressure [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003323 name: type B pancreatic cell development namespace: biological_process def: "The process whose specific outcome is the progression of a type B pancreatic cell over time, from its formation to the mature structure. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell development" EXACT [GOC:mah] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0002068 ! glandular epithelial cell development relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003326 name: pancreatic A cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003310 ! pancreatic A cell differentiation [Term] id: GO:0003327 name: type B pancreatic cell fate commitment namespace: biological_process def: "The commitment of a cell to a type B pancreatic cell fate and its capacity to differentiate into a type B pancreatic cell. A type B pancreatic cell is a cell located towards center of the islets of Langerhans that secretes insulin." [CL:0000169, GOC:dph] synonym: "pancreatic B cell fate commitment" EXACT [GOC:mah] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003309 ! type B pancreatic cell differentiation [Term] id: GO:0003328 name: pancreatic D cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003311 ! pancreatic D cell differentiation [Term] id: GO:0003329 name: pancreatic PP cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0003312 ! pancreatic PP cell differentiation [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization is_a: GO:1903530 ! regulation of secretion by cell relationship: regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903055 ! positive regulation of extracellular matrix organization is_a: GO:1903532 ! positive regulation of secretion by cell relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:1903054 ! negative regulation of extracellular matrix organization is_a: GO:1903531 ! negative regulation of secretion by cell relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The process in which an amino acid is transported across a membrane." [GOC:dph, GOC:tb] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "amino acid membrane transport" EXACT [] is_a: GO:0006865 ! amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003334 ! keratinocyte development [Term] id: GO:0003336 name: corneocyte desquamation namespace: biological_process def: "The delamination process that results in the shedding of a corneocyte from the surface of the epidermis." [GOC:dph] synonym: "epidermal desquamation" EXACT [GOC:dph] is_a: GO:0060232 ! delamination relationship: part_of GO:0003335 ! corneocyte development [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0035850 ! epithelial cell differentiation involved in kidney development is_a: GO:0060231 ! mesenchymal to epithelial transition is_a: GO:0072202 ! cell differentiation involved in metanephros development relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the metanephros are generated and organized." [GOC:dph, GOC:yaf] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001656 ! metanephros development [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0072215 ! regulation of metanephros development is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis is_a: GO:2000696 ! regulation of epithelial cell differentiation involved in kidney development relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph, GOC:yaf] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0072217 ! negative regulation of metanephros development is_a: GO:0110111 ! negative regulation of animal organ morphogenesis is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium is_a: GO:2000697 ! negative regulation of epithelial cell differentiation involved in kidney development relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis [Term] id: GO:0003341 name: cilium movement namespace: biological_process alt_id: GO:0036142 def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "ciliary motility" RELATED [] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "flagellar motility" RELATED [] synonym: "flagellar movement" NARROW [GOC:bf] synonym: "flagellum movement" NARROW [] synonym: "microtubule-based flagellum movement" EXACT [] is_a: GO:0007018 ! microtubule-based movement [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0003343 ! septum transversum development [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060039 ! pericardium development [Term] id: GO:0003345 name: proepicardium cell migration involved in pericardium morphogenesis namespace: biological_process def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003344 ! pericardium morphogenesis [Term] id: GO:0003346 name: epicardium-derived cell migration to the myocardium namespace: biological_process def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development [Term] id: GO:0003347 name: epicardial cell to mesenchymal cell transition namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] is_a: GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0045446 ! endothelial cell differentiation [Term] id: GO:0003349 name: epicardium-derived cardiac endothelial cell differentiation namespace: biological_process def: "The process in which an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0003348 ! cardiac endothelial cell differentiation [Term] id: GO:0003350 name: pulmonary myocardium development namespace: biological_process def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060841 ! venous blood vessel development [Term] id: GO:0003351 name: epithelial cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph] synonym: "cilium movement involved in fluid flow" RELATED [GOC:cilia] synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process alt_id: GO:1900172 def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "regulation of flagellum movement" RELATED [] synonym: "regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0060632 ! regulation of microtubule-based movement relationship: regulates GO:0003341 ! cilium movement [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process alt_id: GO:1900174 def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "positive regulation of flagellar movement" RELATED [GOC:TermGenie] synonym: "positive regulation of flagellum movement" RELATED [] synonym: "positive regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement relationship: positively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process alt_id: GO:1900173 def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "negative regulation of flagellum movement" RELATED [] synonym: "negative regulation of microtubule-based flagellum movement" EXACT [] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement relationship: negatively_regulates GO:0003341 ! cilium movement [Term] id: GO:0003355 name: cilium movement involved in otolith formation namespace: biological_process def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph] is_a: GO:0003351 ! epithelial cilium movement relationship: part_of GO:0032475 ! otolith formation [Term] id: GO:0003356 name: regulation of cilium beat frequency namespace: biological_process alt_id: GO:0036144 def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. synonym: "regulation of flagellum beat frequency" RELATED [] synonym: "regulation of microtubule-based flagellum beat frequency" EXACT [] is_a: GO:0003352 ! regulation of cilium movement [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003359 name: noradrenergic neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0003357 ! noradrenergic neuron differentiation [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation relationship: part_of GO:0003360 ! brainstem development [Term] id: GO:0003362 name: noradrenergic neuron fate commitment involved in brainstem development namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003359 ! noradrenergic neuron fate commitment relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development [Term] id: GO:0003363 name: lamellipodium assembly involved in ameboidal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030032 ! lamellipodium assembly relationship: part_of GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0003364 name: lamellipodium assembly involved in mesendodermal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0003366 name: cell-matrix adhesion involved in ameboidal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003368 name: cell-matrix adhesion involved in mesendodermal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003369 name: establishment of cell polarity involved in mesendodermal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration [Term] id: GO:0003370 name: cell-cell adhesion involved in mesendodermal cell migration namespace: biological_process def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration is_a: GO:0070586 ! cell-cell adhesion involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration [Term] id: GO:0003372 name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration [Term] id: GO:0003373 name: dynamin family protein polymerization involved in membrane fission namespace: biological_process def: "The process of creating dynamin family protein polymers, compounds composed of a large number of dynamin family protein monomers. Dynamin family protein polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0090148 ! membrane fission [Term] id: GO:0003374 name: dynamin family protein polymerization involved in mitochondrial fission namespace: biological_process def: "The process of creating dynamin protein family polymers, compounds composed of a large number of dynamin family monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003373 ! dynamin family protein polymerization involved in membrane fission [Term] id: GO:0003375 name: regulation of dynamin family protein polymerization involved in membrane fission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of dynamin family protein polymerization involved in mitochondrial fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0003373 ! dynamin family protein polymerization involved in membrane fission [Term] id: GO:0003376 name: sphingosine-1-phosphate receptor signaling pathway namespace: biological_process alt_id: GO:0001789 def: "A series of molecular signals initiated by the sphingolipid sphingosine-1-phosphate (S1P) binding to a receptor on the surface of the cell, and which proceeds with the activated receptor transmitting the signal by promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ascb_2009, GOC:signaling, PMID:14592418, PMID:22001186, Reactome:R-HSA-419428] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/15822 synonym: "S1P receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P signaling pathway" RELATED [GOC:bf] synonym: "S1P-activated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] synonym: "S1P-activated GPCR signaling pathway" EXACT [GOC:bf] synonym: "S1P-stimulated signal transduction pathway" EXACT [PMID:22001186] synonym: "sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "sphingolipid signalling pathway" BROAD [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0090520 ! sphingolipid mediated signaling pathway [Term] id: GO:0003377 name: obsolete regulation of apoptosis by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:signaling, GOC:tb] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "regulation of apoptosis by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of apoptosis by sphingolipid signalling pathway" BROAD [GOC:mah] is_obsolete: true [Term] id: GO:0003378 name: obsolete regulation of inflammatory response by sphingosine-1-phosphate signaling pathway namespace: biological_process def: "OBSOLETE. A sphingosine-1-phosphate signaling pathway that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "regulation of inflammatory response by sphingolipid signaling pathway" BROAD [GOC:bf] synonym: "regulation of inflammatory response by sphingolipid signalling pathway" BROAD [GOC:mah] is_obsolete: true [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration relationship: part_of GO:0042074 ! cell migration involved in gastrulation [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process that results in the contraction of the apical end of a polarized columnar epithelial cell, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation [Term] id: GO:0003385 name: cell-cell signaling involved in amphid sensory organ development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in amphid sensory organ development" EXACT [GOC:mah] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003386 name: amphid sensory organ development namespace: biological_process def: "The progression of the amphid sensory organ over time, from its formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0003387 name: neuron differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003388 name: neuron development involved in amphid sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development [Term] id: GO:0003389 name: retrograde extension namespace: biological_process def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031175 ! neuron projection development [Term] id: GO:0003390 name: dendrite development by retrograde extension namespace: biological_process def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003389 ! retrograde extension is_a: GO:0016358 ! dendrite development [Term] id: GO:0003391 name: amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development [Term] id: GO:0003392 name: cell adhesion involved in retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003393 name: neuron migration involved in retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001764 ! neuron migration relationship: part_of GO:0003389 ! retrograde extension [Term] id: GO:0003394 name: cell adhesion involved in dendrite retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003392 ! cell adhesion involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003395 name: neuron migration involved in dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003393 ! neuron migration involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension [Term] id: GO:0003396 name: cell adhesion involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003397 name: neuron migration involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension [Term] id: GO:0003398 name: glial cell differentiation involved in amphid sensory organ development namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0003386 ! amphid sensory organ development [Term] id: GO:0003399 name: cytoneme morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0120039 ! plasma membrane bounded cell projection morphogenesis [Term] id: GO:0003400 name: regulation of COPII vesicle coating namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis relationship: regulates GO:0048208 ! COPII vesicle coating [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway relationship: part_of GO:0003401 ! axis elongation [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis [Term] id: GO:0003405 name: optic vesicle elongation namespace: biological_process def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060041 ! retina development in camera-type eye [Term] id: GO:0003408 name: optic cup formation involved in camera-type eye development namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003409 name: optic cup structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "optic cup structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development [Term] id: GO:0003410 name: anterior rotation of the optic cup namespace: biological_process def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0003412 name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0002063 ! chondrocyte development [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0098868 ! bone growth [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis is_a: GO:0061448 ! connective tissue development relationship: part_of GO:0003416 ! endochondral bone growth [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process in which a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003419 name: growth plate cartilage chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003420 name: regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0046620 ! regulation of organ growth is_a: GO:0061035 ! regulation of cartilage development is_a: GO:1903010 ! regulation of bone development is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003421 name: growth plate cartilage axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process in which the anatomical structures of growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development [Term] id: GO:0003423 name: growth plate cartilage chondrocyte division namespace: biological_process def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051301 ! cell division relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation [Term] id: GO:0003424 name: establishment of cell polarity involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division [Term] id: GO:0003425 name: establishment of mitotic spindle orientation involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000132 ! establishment of mitotic spindle orientation is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division is_a: GO:0090176 ! microtubule cytoskeleton organization involved in establishment of planar polarity [Term] id: GO:0003426 name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division [Term] id: GO:0003427 name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0051302 ! regulation of cell division is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:0060071 ! Wnt signaling pathway, planar cell polarity pathway is_a: GO:2000114 ! regulation of establishment of cell polarity relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division [Term] id: GO:0003428 name: chondrocyte intercalation involved in growth plate cartilage morphogenesis namespace: biological_process def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0060029 ! convergent extension involved in organogenesis [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process in which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis is_a: GO:0003422 ! growth plate cartilage morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis [Term] id: GO:0003434 name: BMP signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "BMP signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003435 name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:mah] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis [Term] id: GO:0003673 name: obsolete Gene_Ontology namespace: biological_process def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "Gene_Ontology" EXACT [] is_obsolete: true [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs. These actions are described from two distinct but related perspectives: (1) biochemical activity, and (2) role as a component in a larger system/process." [GOC:pdt] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. When this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. Despite its name, this is not a type of 'function' in the sense typically defined by upper ontologies such as Basic Formal Ontology (BFO). It is instead a BFO:process carried out by a single gene product or complex. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "molecular function" EXACT [] [Term] id: GO:0003675 name: obsolete protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "protein" EXACT [] is_obsolete: true [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function alt_id: GO:0000496 def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "base pairing" NARROW [] is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function alt_id: GO:0043566 def: "Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] synonym: "structure specific DNA binding" RELATED [] synonym: "structure-specific DNA binding" RELATED [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah] is_a: GO:0004386 ! helicase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003680 name: AT DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] synonym: "AT binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003681 name: bent DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732, PMID:20404130] subset: goslim_chembl subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0003683 name: obsolete lamin/chromatin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two functions. synonym: "lamin/chromatin binding" EXACT [] is_obsolete: true consider: GO:0003682 consider: GO:0005521 [Term] id: GO:0003684 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003685 name: obsolete DNA repair protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. synonym: "DNA repair protein" EXACT [] is_obsolete: true consider: GO:0003684 [Term] id: GO:0003686 name: obsolete DNA repair enzyme namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. synonym: "DNA repair enzyme" EXACT [] is_obsolete: true consider: GO:0003684 [Term] id: GO:0003687 name: obsolete DNA replication factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication factor" EXACT [] is_obsolete: true consider: GO:0006260 [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:curators] synonym: "ARS binding" NARROW [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003689 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: reactome:R-HSA-176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity [Term] id: GO:0003690 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh, GOC:vw] synonym: "dsDNA binding" EXACT [GOC:elh] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003691 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0003692 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0003693 name: P-element binding namespace: molecular_function def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, PMID:9440262] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003694 name: obsolete plasmid binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732] comment: This term was made obsolete because it refers to component information. synonym: "plasmid binding" EXACT [] synonym: "plasmid-associated protein" RELATED [] is_obsolete: true consider: GO:0003677 consider: GO:0005727 [Term] id: GO:0003695 name: random coil DNA binding namespace: molecular_function alt_id: GO:0016017 def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh, GOC:vw, PMID:22976174] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0003677 ! DNA binding [Term] id: GO:0003700 name: DNA-binding transcription factor activity namespace: molecular_function alt_id: GO:0000130 alt_id: GO:0001071 alt_id: GO:0001130 alt_id: GO:0001131 alt_id: GO:0001151 alt_id: GO:0001199 alt_id: GO:0001204 def: "A protein or a member of a complex that interacts selectively and non-covalently with a specific DNA sequence (sometimes referred to as a motif) within the regulatory region of a gene to modulate transcription. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons." [GOC:txnOH-2018] comment: Curator guidance: Note that most DNA-binding transcription factors do not have enzymatic activity. The presence of specific domains known to be present in DNA-binding transcription factors (HOX, GATA etc) should be used to help decide whether a protein is a DNA binding transcription factor or a coregulator. If a protein has an enzymatic activity (for example, ubiquitin ligase, histone acetyl transferase) and no known DNA binding domain, consider annotating to GO:0003712 transcription coregulator activity. Special care should be taken with proteins containing Myb/SANT and ARID domains, since only a subset of proteins containing these domains are DNA-binding transcription factors for specific genes. \nChanged definition see https://github.com/geneontology/go-ontology/issues/15704\nMerged term see https://github.com/geneontology/go-ontology/issues/16534 subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial-type DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase core promoter proximal region sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription enhancer sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] synonym: "bacterial-type RNA polymerase transcription factor activity, sequence-specific DNA binding" NARROW [] synonym: "DNA binding transcription factor activity" EXACT [] synonym: "gene-specific transcription factor activity" EXACT [] synonym: "metal ion regulated sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "metal ion regulated sequence-specific DNA binding transcription factor activity" NARROW [] synonym: "nucleic acid binding transcription factor activity" BROAD [] synonym: "sequence-specific DNA binding bacterial-type RNA polymerase transcription factor activity" NARROW [] synonym: "sequence-specific DNA binding transcription factor activity" EXACT [] synonym: "transcription factor activity" BROAD [] synonym: "transcription factor activity, bacterial-type RNA polymerase core promoter proximal region sequence-specific binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase proximal promoter sequence-specific DNA binding" NARROW [] synonym: "transcription factor activity, bacterial-type RNA polymerase transcription enhancer sequence-specific binding" NARROW [] synonym: "transcription factor activity, metal ion regulated sequence-specific DNA binding" NARROW [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0003701 name: obsolete RNA polymerase I transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase I transcription factor activity" EXACT [] is_obsolete: true consider: GO:0001181 consider: GO:0006360 [Term] id: GO:0003702 name: obsolete RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000981 consider: GO:0006366 [Term] id: GO:0003704 name: obsolete specific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "specific RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000981 consider: GO:0006366 [Term] id: GO:0003706 name: obsolete ligand-regulated transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II in response to a ligand." [GOC:curators] comment: This term was made obsolete because it does not convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. synonym: "ligand-regulated transcription factor activity" EXACT [] is_obsolete: true consider: GO:0004879 consider: GO:0038049 [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone and transmitting the signal within the cell to initiate a change in cell activity or function." [GOC:signaling, PMID:14708019] comment: Some steroid hormone receptors reside in the plasma membrane and signal through second messengers or other intracellular signal transduction pathways. For steroid hormone receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: nuclear receptor activity ; GO:0004879' or nuclear receptor transcription coactivator activity ; GO:0030374'. is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0003709 name: obsolete RNA polymerase III transcription factor activity namespace: molecular_function def: "OBSOLETE. Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "RNA polymerase III transcription factor activity" EXACT [] is_obsolete: true consider: GO:0000995 consider: GO:0006383 [Term] id: GO:0003711 name: transcription elongation regulator activity namespace: molecular_function def: "A molecular function that regulates transcriptional elongation by enabling the transition from transcription initiation to elongation or by altering the elongation properties of the enzyme during the elongation phase of transcription." [GOC:txnOH-2018, PMID:23878398, PMID:28892040] comment: Restored term, see https://github.com/geneontology/go-ontology/issues/14398 synonym: "transcription elongation factor activity" EXACT [] synonym: "transcription elongation regulator activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0003712 name: transcription coregulator activity namespace: molecular_function alt_id: GO:0001104 alt_id: GO:0016455 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to either activate or repress the transcription of specific genes. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class modulates interactions of DNA-binding transcription factor with other transcription coregulators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867, PMID:24203923, PMID:25957681, Wikipedia:Transcription_coregulator] comment: Curator guidance: Most transcription coregulators do not bind DNA. Those that do usually bind DNA either in a non-specific or non-direct manner. If a protein binds DNA specifically, consider annotating to GO:0003700 DNA binding transcription factor activity.\nFixed term label and definition, see https://github.com/geneontology/go-ontology/issues/15998; Changed parents, see https://github.com/geneontology/go-ontology/issues/15536; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 synonym: "RNA polymerase II transcriptional cofactor activity" RELATED [] synonym: "transcription cofactor activity" EXACT [] synonym: "transcriptional co-regulator" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0003713 name: transcription coactivator activity namespace: molecular_function alt_id: GO:0001105 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to activate the transcription of specific genes. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. Another type of coregulator activity is the bridging of a DNA-binding transcription factor to the basal transcription machinery. The Mediator complex, which bridges transcription factors and RNA polymerase, is also a transcription coactivator." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] comment: Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 synonym: "RNA polymerase II transcription co-activator activity" RELATED [] synonym: "RNA polymerase II transcription coactivator activity" RELATED [] synonym: "RNA polymerase II transcription mediator activity" RELATED [] synonym: "transcription co-activator activity" EXACT [] synonym: "transcription coactivator activity" EXACT [] is_a: GO:0003712 ! transcription coregulator activity [Term] id: GO:0003714 name: transcription corepressor activity namespace: molecular_function alt_id: GO:0001106 def: "A protein or a member of a complex that interacts specifically and non-covalently with a DNA-bound DNA-binding transcription factor to repress the transcription of specific genes. Corepressors often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second ATP-dependent class modifies the conformation of chromatin. A third class occludes DNA-binding transcription factor protein-protein interaction domains. A third class of corepressors prevents interactions of DNA bound DNA-binding transcription factor with coactivators." [GOC:txnOH-2018, PMID:10213677, PMID:16858867] comment: Updated definition, see https://github.com/geneontology/go-ontology/issues/15998; Merged children terms, see https://github.com/geneontology/go-ontology/issues/15665 synonym: "RNA polymerase II transcription co-repressor activity" RELATED [] synonym: "RNA polymerase II transcription corepressor activity" RELATED [] synonym: "transcription co-repressor activity" EXACT [] synonym: "transcription corepressor activity" EXACT [] is_a: GO:0003712 ! transcription coregulator activity [Term] id: GO:0003715 name: obsolete transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription termination factor activity" EXACT [] synonym: "transcriptional termination factor activity" EXACT [] is_obsolete: true consider: GO:0006353 [Term] id: GO:0003716 name: obsolete RNA polymerase I transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription termination factor activity" EXACT [] synonym: "RNA polymerase I transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006363 [Term] id: GO:0003717 name: obsolete RNA polymerase II transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription termination factor activity" EXACT [] synonym: "RNA polymerase II transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006369 [Term] id: GO:0003718 name: obsolete RNA polymerase III transcription termination factor activity namespace: molecular_function def: "OBSOLETE. Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription termination factor activity" EXACT [] synonym: "RNA polymerase III transcription termination factor activity" EXACT [] is_obsolete: true consider: GO:0006386 [Term] id: GO:0003719 name: obsolete transcription factor binding, cytoplasmic sequestering namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process rather than a function. synonym: "transcription factor binding, cytoplasmic sequestering" EXACT [] is_obsolete: true replaced_by: GO:0042994 [Term] id: GO:0003720 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] xref: EC:2.7.7 xref: reactome:R-HSA-163090 "Elongation Of The Telomeric Chromosome End" xref: reactome:R-HSA-164617 "Elongation of Extended Telomeric Chromosome End" is_a: GO:0003964 ! RNA-directed DNA polymerase activity [Term] id: GO:0003721 name: telomerase RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] is_a: GO:0003964 ! RNA-directed DNA polymerase activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0003723 name: RNA binding namespace: molecular_function alt_id: GO:0000498 alt_id: GO:0044822 def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "base pairing with RNA" NARROW [] synonym: "poly(A) RNA binding" RELATED [] synonym: "poly(A)-RNA binding" RELATED [] synonym: "poly-A RNA binding" RELATED [] xref: reactome:R-HSA-203922 "Exportin-5 recognizes 3' overhang of pre-miRNA" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003724 name: RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] xref: EC:2.7.7 xref: reactome:R-HSA-72647 "Cap-bound mRNA is activated by helicases" is_a: GO:0004386 ! helicase activity is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0003725 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] synonym: "dsRNA binding" EXACT [GOC:ecd] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003726 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function alt_id: GO:0003971 def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] synonym: "double-stranded RNA specific editase activity" RELATED [] xref: reactome:R-HSA-77614 "Deamination at C6 position of adenosine in Editosome (ADAR1)" xref: reactome:R-HSA-77615 "Deamination at C6 position of adenosine in Editosome (ADAR2)" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function alt_id: GO:0000499 def: "Interacting selectively and non-covalently with messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns." [GOC:kmv, GOC:pr, SO:0000234] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "base pairing with mRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003730 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0003731 name: obsolete mRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. synonym: "mRNA cap binding" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0003732 name: obsolete snRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. synonym: "snRNA cap binding" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0003733 name: obsolete ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "ribonucleoprotein" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0003734 name: obsolete small nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] is_obsolete: true replaced_by: GO:0030532 [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0003743 name: translation initiation factor activity namespace: molecular_function alt_id: GO:0003744 alt_id: GO:0003745 def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732] xref: reactome:R-HSA-72621 "Ribosomal scanning" xref: reactome:R-HSA-72697 "Start codon recognition" xref: reactome:R-HSA-72722 "eIF2 activation" is_a: GO:0008135 ! translation factor activity, RNA binding [Term] id: GO:0003746 name: translation elongation factor activity namespace: molecular_function alt_id: GO:0008182 alt_id: GO:0008183 def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732] xref: reactome:R-HSA-192704 "Synthesis of PB1-F2" xref: reactome:R-HSA-192841 "Viral Protein Synthesis" is_a: GO:0008135 ! translation factor activity, RNA binding [Term] id: GO:0003747 name: translation release factor activity namespace: molecular_function alt_id: GO:0003748 alt_id: GO:0003749 def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] is_a: GO:0008079 ! translation termination factor activity [Term] id: GO:0003750 name: obsolete cell cycle regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a single molecular function. synonym: "cell cycle regulator" EXACT [] is_obsolete: true replaced_by: GO:0051726 [Term] id: GO:0003754 name: obsolete chaperone activity namespace: molecular_function alt_id: GO:0003757 alt_id: GO:0003758 alt_id: GO:0003760 alt_id: GO:0003761 def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. synonym: "chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003755 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function alt_id: GO:0004752 alt_id: GO:0042028 def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN xref: reactome:R-HSA-2022073 "Procollagen triple helix formation" xref: reactome:R-HSA-9626816 "PIN1 binds p-S345-NCF1" is_a: GO:0016859 ! cis-trans isomerase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0003756 name: protein disulfide isomerase activity namespace: molecular_function alt_id: GO:0006467 def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1, GOC:vw, http://en.wikipedia.org/wiki/Protein_disulfide-isomerase#Function] synonym: "disulphide bond biosynthesis" EXACT [] synonym: "disulphide bond formation" EXACT [] synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "protein thiol-disulfide exchange" EXACT [] synonym: "protein thiol-disulphide exchange" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: MetaCyc:5.3.4.1-RXN xref: reactome:R-HSA-8950113 "IL12A binds IL12B" xref: reactome:R-HSA-8950183 "IL12B binds IL23A" xref: reactome:R-HSA-8950456 "IL12B dimerizes" is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0003759 name: obsolete glycoprotein-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "glycoprotein-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003762 name: obsolete histone-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "histone-specific chaperone activity" EXACT [] synonym: "nucleosome assembly chaperone" EXACT [] is_obsolete: true consider: GO:0006333 consider: GO:0006334 consider: GO:0034728 consider: GO:0042393 consider: GO:0043486 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003763 name: obsolete chaperonin ATPase activity namespace: molecular_function alt_id: GO:0003764 alt_id: GO:0003765 alt_id: GO:0003766 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "chaperonin" EXACT [] synonym: "chaperonin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0003767 name: obsolete co-chaperone activity namespace: molecular_function alt_id: GO:0003768 alt_id: GO:0003769 alt_id: GO:0003770 alt_id: GO:0003771 def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "co-chaperone activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003772 name: obsolete co-chaperonin activity namespace: molecular_function def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "co-chaperonin activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003773 name: obsolete heat shock protein activity namespace: molecular_function def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. synonym: "heat shock protein activity" EXACT [] is_obsolete: true consider: GO:0006986 consider: GO:0042026 [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of the generation of force resulting either in movement along a microfilament or microtubule, or in torque resulting in membrane scission, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, GOC:vw, ISBN:0815316194, PMID:11242086] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_plant xref: reactome:R-HSA-1861595 "Extension of pseudopodia by myosin-X in a PI3K dependent manner" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003775 name: obsolete axonemal motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. synonym: "axonemal motor activity" EXACT [] is_obsolete: true consider: GO:0003777 consider: GO:0005930 [Term] id: GO:0003776 name: obsolete muscle motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes anatomy information. synonym: "muscle motor activity" EXACT [] is_obsolete: true replaced_by: GO:0000146 consider: GO:0006936 consider: GO:0043292 [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: reactome:R-HSA-177479 "Axonal transport of NGF:Trk complexes" xref: reactome:R-HSA-265160 "Insulin secretory granule translocates to cell cortex" is_a: GO:0003774 ! motor activity [Term] id: GO:0003778 name: obsolete dynactin motor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. synonym: "dynactin motor" EXACT [] is_obsolete: true [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0003780 name: obsolete actin cross-linking activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] comment: This term was made obsolete because it represents a combination of molecular functions. synonym: "actin cross-linking activity" EXACT [] is_obsolete: true consider: GO:0030674 consider: GO:0051015 [Term] id: GO:0003781 name: obsolete actin bundling activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin bundling activity" EXACT [] is_obsolete: true replaced_by: GO:0051017 [Term] id: GO:0003782 name: obsolete F-actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "F-actin capping activity" EXACT [] is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003783 name: obsolete barbed-end actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "barbed-end actin capping activity" EXACT [] is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003784 name: obsolete barbed-end actin capping/severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes two biological processes. synonym: "barbed-end actin capping/severing activity" EXACT [] is_obsolete: true consider: GO:0051014 consider: GO:0051016 [Term] id: GO:0003785 name: actin monomer binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0003786 name: actin lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah] is_a: GO:0051015 ! actin filament binding [Term] id: GO:0003787 name: obsolete actin depolymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin depolymerizing activity" EXACT [] is_obsolete: true replaced_by: GO:0030042 [Term] id: GO:0003788 name: obsolete actin monomer sequestering activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process, not an activity. synonym: "actin monomer sequestering activity" EXACT [] is_obsolete: true replaced_by: GO:0042989 [Term] id: GO:0003789 name: obsolete actin filament severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "actin filament severing activity" EXACT [] is_obsolete: true replaced_by: GO:0051014 [Term] id: GO:0003790 name: obsolete actin modulating activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not make sense. synonym: "actin modulating activity" EXACT [] is_obsolete: true consider: GO:0030036 [Term] id: GO:0003791 name: obsolete membrane associated actin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "membrane associated actin binding" EXACT [] is_obsolete: true consider: GO:0003779 consider: GO:0016020 [Term] id: GO:0003792 name: obsolete regulation of actin thin filament length activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the term belongs in the process ontology. synonym: "regulation of actin thin filament length activity" EXACT [] is_obsolete: true replaced_by: GO:0030832 [Term] id: GO:0003793 name: obsolete defense/immunity protein activity namespace: molecular_function def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "defence/immunity protein activity" EXACT [] synonym: "defense/immunity protein activity" EXACT [] is_obsolete: true consider: GO:0006952 [Term] id: GO:0003794 name: obsolete acute-phase response protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "acute-phase response protein activity" EXACT [] is_obsolete: true consider: GO:0006953 [Term] id: GO:0003795 name: obsolete antimicrobial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antimicrobial peptide activity" EXACT [] is_obsolete: true consider: GO:0019730 [Term] id: GO:0003796 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the beta-(1->4) linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues in a peptidoglycan." [EC:3.2.1.17, PMID:22748813] synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: MetaCyc:3.2.1.17-RXN xref: reactome:R-HSA-8862320 "LYZ hydrolyzes peptidoglycans in the bacterial cell wall" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0003797 name: obsolete antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0042742 [Term] id: GO:0003798 name: obsolete male-specific antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "male-specific antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050831 [Term] id: GO:0003799 name: obsolete antifungal peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "antifungal peptide activity" EXACT [] is_obsolete: true consider: GO:0050832 [Term] id: GO:0003800 name: obsolete antiviral response protein activity namespace: molecular_function def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "antiviral response protein activity" EXACT [] is_obsolete: true consider: GO:0009615 [Term] id: GO:0003801 name: obsolete blood coagulation factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "blood coagulation factor activity" EXACT [] is_obsolete: true consider: GO:0004252 consider: GO:0007596 [Term] id: GO:0003802 name: obsolete coagulation factor VIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] synonym: "coagulation factor VIIa activity" EXACT [] xref: EC:3.4.21.21 xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003803 name: obsolete coagulation factor IXa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] synonym: "coagulation factor IXa activity" EXACT [] xref: EC:3.4.21.22 xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003804 name: obsolete coagulation factor Xa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "coagulation factor Xa activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003805 name: obsolete coagulation factor XIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "coagulation factor XIa activity" EXACT [] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003806 name: obsolete coagulation factor XIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] comment: This term was made obsolete because it represents a gene product. synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "coagulation factor XIIa activity" EXACT [] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003807 name: obsolete plasma kallikrein activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "plasma kallikrein activity" EXACT [] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003808 name: obsolete protein C (activated) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein C (activated) activity" EXACT [] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003809 name: obsolete thrombin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin activity" EXACT [] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003810 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: MetaCyc:2.3.2.13-RXN xref: reactome:R-HSA-140851 "fibrin multimer -> fibrin multimer, crosslinked + NH4+" xref: reactome:R-HSA-6810894 "Envoplakin, periplakin, involucrin, SPR binding mediated by TGM1 crosslinking" xref: RESID:AA0124 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003811 name: obsolete complement activity namespace: molecular_function def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "complement activity" EXACT [] is_obsolete: true consider: GO:0006956 [Term] id: GO:0003812 name: obsolete alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] comment: This term was made obsolete because it represents a gene product. synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "alternative-complement-pathway C3/C5 convertase activity" EXACT [] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003813 name: obsolete classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] comment: This term was made obsolete because it represents a gene product. synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "classical-complement-pathway C3/C5 convertase activity" EXACT [] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003815 name: obsolete complement component C1r activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement component C1r activity" EXACT [] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003816 name: obsolete complement component C1s activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement component C1s activity" EXACT [] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003817 name: obsolete complement factor D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] comment: This term was made obsolete because it represents a gene product. synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "complement factor D activity" EXACT [] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003818 name: obsolete complement factor I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] comment: This term was made obsolete because it represents a gene product. synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "complement factor I activity" EXACT [] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003819 name: obsolete major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "major histocompatibility complex antigen" EXACT [] synonym: "MHC protein" EXACT [] is_obsolete: true [Term] id: GO:0003820 name: obsolete class I major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "class I major histocompatibility complex antigen" EXACT [] is_obsolete: true consider: GO:0042612 [Term] id: GO:0003821 name: obsolete class II major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "class II major histocompatibility complex antigen" EXACT [] is_obsolete: true consider: GO:0042613 [Term] id: GO:0003822 name: obsolete MHC-interacting protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "MHC-interacting protein" EXACT [] is_obsolete: true [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732, ISBN:0721662544] subset: goslim_chembl subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [GOC:vw, ISBN:0198506732] subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function [Term] id: GO:0003825 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose-6-phosphate = UDP + alpha,alpha-trehalose-6-phosphate." [EC:2.4.1.15] synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: MetaCyc:TREHALOSE6PSYN-RXN xref: RHEA:18889 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003826 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0003827 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(alpha-D-mannosyl)-beta-D-mannosyl-R + UDP-N-acetyl-alpha-D-glucosamine = 3-(2-[N-acetyl-beta-D-glucosaminyl]-alpha-D-mannosyl)-beta-D-mannosyl-R + H(+) + UDP." [EC:2.4.1.101, RHEA:11456] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: KEGG:R05983 xref: MetaCyc:2.4.1.101-RXN xref: reactome:R-HSA-964768 "Addition of GlcNAc to the glycan on the A arm" xref: RHEA:11456 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003828 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-(2->8)-alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1 alpha-(2->8)-sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha-2,8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: MetaCyc:2.4.99.8-RXN xref: reactome:R-HSA-1022133 "ST8SIA2,3,6 transfer Neu5Ac to terminal Gal of N-glycans" xref: reactome:R-HSA-4084978 "ST8SIA1-6 transfer Neu5Ac to terminal Neu5Ac residues" xref: reactome:R-HSA-422454 "Polysialylation of NCAM1" xref: RHEA:19313 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003829 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-(1->3)-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->6)]-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: MetaCyc:2.4.1.102-RXN xref: reactome:R-HSA-914012 "GCNTs transfer GlcNAc from UDP-GlcNAc to Core 1 mucins" xref: reactome:R-HSA-914018 "Addition of GlcNAc to Core 3 forms a Core 4 glycoprotein" xref: RHEA:18705 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003830 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN xref: reactome:R-HSA-975926 "Addition of a bifurcating GlcNAc to the N-glycan by MGAT3" is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0003831 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "beta-N-acetyl-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: MetaCyc:2.4.1.38-RXN xref: reactome:R-HSA-1912352 "Galactosylation of Pre-NOTCH" xref: reactome:R-HSA-2025723 "B4GALTs transfer Gal to the N-glycan precursor" xref: reactome:R-HSA-2046265 "B4GALTs transfer Gal to the keratan chain" xref: reactome:R-HSA-2046298 "B4GALTs transfer Gal to a branch of keratan" xref: reactome:R-HSA-975919 "Addition of galactose by beta 4-galactosyltransferases" xref: RHEA:22932 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003832 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-beta-alanyl dopamine + H2O = dopamine + beta-alanine." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003833 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732, PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0003834 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O(2) = 2 retinal." [EC:1.14.99.36, RHEA:10407] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: KEGG:R00032 xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN xref: reactome:R-HSA-975635 "BCMO1:Fe2+ cleaves betaC to atRAL" xref: RHEA:10407 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003835 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->4)-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-(2->6)-beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: MetaCyc:2.4.99.1-RXN xref: reactome:R-HSA-4085033 "ST6GAL1,2 transfer Neu5Ac to terminal Gal (alpha-2,6 link)" xref: reactome:R-HSA-975902 "ST6GAL1 transfers Neu5Ac to terminal Gal of N-glycans" xref: reactome:R-HSA-977071 "Sialyltransferase I can add sialic acid to the Tn antigen at the alpha 6 position" xref: reactome:R-HSA-977228 "Sialyltransferase I can add sialic acid to the T antigen at the alpha 6 position" xref: RHEA:11836 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003836 name: beta-galactoside (CMP) alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-(2->3)-beta-D-galactosyl-(1->3)-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: MetaCyc:2.4.99.4-RXN xref: reactome:R-HSA-1022129 "ST3GAL4 transfers Neu5Ac to terminal Gal of N-glycans" xref: reactome:R-HSA-1912378 "Sialylation of Pre-NOTCH" xref: reactome:R-HSA-2046285 "The keratan chain can be capped by N-acetylneuraminic acid" xref: reactome:R-HSA-4084984 "ST3GAL1-6 transfer Neu5Ac to terminal Gal (alpha-2,3 link)" xref: reactome:R-HSA-981497 "ST3GAL1-4 can add a sialic acid to the T antigen at the alpha 3 position" xref: RHEA:21616 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003837 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: reactome:R-HSA-73591 "beta-ureidopropionate + H2O => beta-alanine + NH4+ + CO2" xref: reactome:R-HSA-73620 "beta-ureidoisobutyrate + H2O => 3-aminoisobutyrate + NH4+ + CO2" xref: RHEA:11184 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003838 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: MetaCyc:RXN3O-178 xref: RHEA:21128 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0003839 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [PMID:18515354] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [] synonym: "L-glutamic cyclase activity" EXACT [] xref: EC:4.3.2.9 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN xref: reactome:R-HSA-1247922 "GGCT transforms gGluCys to OPRO" xref: reactome:R-HSA-6785928 "CHAC1,2 cleaves GSH to OPRO and CysGly" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0003840 name: obsolete gamma-glutamyltransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] comment: This term was obsoleted because it does not correspond to a physiological reaction.\nUsage comment: The gene family commonly referred to as gamma-glutamyl transferases (GGT) catalyze hydrolysis of gamma-glutamyl bonds in gamma-glutamyl compounds such as glutathione. In a test tube one can set up conditions in which the enzyme will transfer the gamma-glutamyl portion of the substrate to an acceptor molecule, but this requires non-physiologic conditions, including millmolar concentrations of an acceptor such as glygly. This reaction is used in assays to detect the presence of the enzyme, but is not a physiological function of members of the GGT family (PMC4388159), which should be annotated to a suitable hydrolysis term instead (e.g. glutathione hydrolase activity). synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: KEGG:R04159 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN is_obsolete: true consider: GO:0036374 [Term] id: GO:0003841 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function alt_id: GO:0004469 def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate." [EC:2.3.1.51, GOC:ab] synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" RELATED [EC:2.3.1.51] xref: EC:2.3.1.51 xref: MetaCyc:RXN-1623 xref: reactome:R-HSA-1482539 "1-acyl LPG is acylated to PG by LPGAT" xref: reactome:R-HSA-1482547 "1-acyl LPC is acylated to PC by LPCAT" xref: reactome:R-HSA-1482548 "1-acyl LPA is acylated to PA by AGPAT5 (OM)" xref: reactome:R-HSA-1482598 "1-acyl LPI is acylated to PI by MBOAT7" xref: reactome:R-HSA-1482636 "1-acyl LPS is acylated to PS by LPSAT" xref: reactome:R-HSA-1482667 "1-acyl LPE is acylated to PE by LPEAT" xref: reactome:R-HSA-1482689 "1-acyl LPG is acylated to PG by CRLS1 (IM)" xref: reactome:R-HSA-1482894 "CL and 1-acyl LPE are converted to MLCL and PE by TAZ (IM) (Reversible)" xref: reactome:R-HSA-75885 "1-acyl LPA is acylated to PA by AGPAT (LPAAT)" xref: reactome:R-HSA-8849345 "LPAAT3 acylates lysophosphatidylcholine to yield phosphatidylcholine" xref: RHEA:19709 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity is_a: GO:0042171 ! lysophosphatidic acid acyltransferase activity [Term] id: GO:0003842 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H(+)." [EC:1.5.1.12] synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: reactome:R-HSA-6784399 "ALDH4A1 dimer dehydrogenates 4-OH-L-glutamate semialdehyde to 4-OH-L-glutamate" xref: reactome:R-HSA-70679 "ALDH4A1 oxidises L-GluSS to Glu" xref: RHEA:16417 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0003843 name: 1,3-beta-D-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + [(1->3)-beta-D-glucosyl](n) = UDP + [(1->3)-beta-D-glucosyl](n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003844 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: reactome:R-HSA-3322005 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-a" xref: reactome:R-HSA-3322016 "GBE1 catalyzes branch formation in polyGlc-GYG2 complexed with GYS2-a" xref: reactome:R-HSA-3322057 "GBE1 catalyzes branch formation in polyGlc-GYG1 complexed with GYS1-b" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0003845 name: 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H(+)." [EC:1.1.1.146, PMID:15761036] synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: reactome:R-HSA-194023 "HSD11B2,HSD11B1 dimer oxidise CORT to COR" xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003846 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: reactome:R-HSA-5696448 "AWAT2 transfers acyl group from acyl-CoA to MAG, forming DAG" xref: reactome:R-HSA-6800334 "MOGAT1,2,3 transfer acyl group from acyl-CoA to 2-acylglycerol to form DAG" xref: RHEA:16741 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: goslim_chembl synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN xref: reactome:R-HSA-8869206 "PAFAH2 hydrolyses PAF to lyso-PAF and acetate" xref: RHEA:17777 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H(+)." [EC:2.7.6.3, RHEA:11412] subset: goslim_chembl synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: KEGG:R03503 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN xref: RHEA:11412 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0003849 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythrose 4-phosphate + H(2)O + phosphoenolpyruvate = 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate." [EC:2.5.1.54, RHEA:14717] comment: Note that this function was formerly EC:4.1.2.15. synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: KEGG:R01826 xref: MetaCyc:DAHPSYN-RXN xref: RHEA:14717 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003850 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose-6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: KEGG:R02587 xref: MetaCyc:3.1.3.68-RXN xref: RHEA:22236 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0003851 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.45 xref: MetaCyc:2.4.1.45-RXN xref: RHEA:10856 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003852 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H(2)O = (2S)-2-isopropylmalate + CoA + H(+)." [EC:2.3.3.13, RHEA:21524] comment: Note that this function was formerly EC:4.1.3.12. synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: KEGG:R01213 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN xref: RHEA:21524 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003853 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN xref: RHEA:13261 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0003854 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+)." [EC:1.1.1.145] synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: MetaCyc:1.1.1.145-RXN xref: reactome:R-HSA-192097 "7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one" xref: reactome:R-HSA-193789 "Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one" xref: reactome:R-HSA-193816 "Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one" xref: reactome:R-HSA-196350 "Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione" xref: reactome:R-HSA-196372 "17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003855 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H(2)O." [EC:4.2.1.10, RHEA:21096] synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: KEGG:R03084 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN xref: RHEA:21096 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003856 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate = 3-dehydroquinate + phosphate." [EC:4.2.3.4, RHEA:21968] xref: EC:4.2.3.4 xref: KEGG:R03083 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN xref: RHEA:21968 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003857 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H(+)." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. synonym: "3-oxoacyl-thioester reductase activity" RELATED [PMID:19685079] synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" NARROW [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] xref: EC:1.1.1.35 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: reactome:R-HSA-193455 "(24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-one-CoA" xref: reactome:R-HSA-193508 "(24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA is oxidized to 3alpha,7alpha-dihydroxy-5beta-cholest-24-one-CoA" xref: reactome:R-HSA-389995 "3-hydroxypristanoyl-CoA + NAD+ => 3-ketoxypristanoyl-CoA + NADH + H+" xref: reactome:R-HSA-390251 "HSD17B4 dehydrogenates 3-hydroxyhexacosanoyl-CoA" xref: reactome:R-HSA-508369 "alpha-methylacetoacetyl-CoA + NADH + H+ <=> alpha-methyl-beta-hydroxybutyryl-CoA + NAD+" xref: reactome:R-HSA-6809264 "EHHADH dehydrogenates 3-hydroxyhexacosanoyl-CoA" xref: reactome:R-HSA-70837 "alpha-methyl-beta-hydroxybutyryl-CoA + NAD+ <=> alpha-methylacetoacetyl-CoA + NADH + H+" xref: reactome:R-HSA-77254 "(S)-3-Hydroxydodecanoyl-CoA+NAD<=>3-Oxododecanoyl-CoA+NADH+H" xref: reactome:R-HSA-77283 "(S)-3-Hydroxytetradecanoyl-CoA+NAD<=>3-Oxotetradecanoyl-CoA+NADH+H" xref: reactome:R-HSA-77303 "(S)-3-Hydroxyhexadecanoyl-CoA+NAD<=>3-Oxopalmitoyl-CoA+NADH+H" xref: reactome:R-HSA-77312 "(S)-Hydroxybutanoyl-CoA+NAD<=>Acetoacetyl-CoA+NADH+H" xref: reactome:R-HSA-77323 "(S)-Hydroxyhexanoyl-CoA+NAD<=>3-Oxohexanoyl-CoA+NADH+H" xref: reactome:R-HSA-77331 "(S)-Hydroxyoctanoyl-CoA+NAD<=>3-Oxooctanoyl-CoA+NADH+H" xref: reactome:R-HSA-77342 "(S)-Hydroxydecanoyl-CoA+NAD<=>3-Oxodecanoyl-CoA+NADH+H" xref: RHEA:22432 xref: UM-BBD_enzymeID:e0664 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003858 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD(+) = acetoacetate + H(+) + NADH." [EC:1.1.1.30, RHEA:20521] synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: KEGG:R01361 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: reactome:R-HSA-5696457 "BDH2 dehydrogenates 3HBA" xref: reactome:R-HSA-73912 "acetoacetic acid + NADH + H+ <=> beta-hydroxybutyrate + NAD+" xref: reactome:R-HSA-73920 "D-beta hydroxybutyrate+NAD+ <=> acetoacetate+NADH+H+" xref: RHEA:20521 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003859 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H(2)O." [EC:4.2.1.55, RHEA:17849] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: KEGG:R03027 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN xref: RHEA:17849 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003860 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: reactome:R-HSA-70881 "beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA" xref: RHEA:20888 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003861 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate." [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003862 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN xref: RHEA:25082 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003863 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0003864 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN xref: RHEA:11824 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0003865 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: MetaCyc:1.3.99.5-RXN xref: reactome:R-HSA-469659 "Testosterone is converted to 5-alpha-dihydroxytestosterone" is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0003866 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoshikimate + phosphoenolpyruvate = 5-O-(1-carboxyvinyl)-3-phosphoshikimate + phosphate." [EC:2.5.1.19, RHEA:21256] synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: KEGG:R03460 xref: MetaCyc:2.5.1.19-RXN xref: RHEA:21256 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003867 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [GOC:mah] synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [] synonym: "aminobutyrate aminotransferase activity" EXACT [] synonym: "aminobutyrate transaminase activity" EXACT [] synonym: "beta-alanine aminotransferase" RELATED [] synonym: "GABA aminotransferase activity" EXACT [] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [] synonym: "gamma-aminobutyrate transaminase activity" EXACT [] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [] xref: MetaCyc:GABATRANSAM-RXN xref: reactome:R-HSA-916855 "Conversion of GABA to Succinate Semialdehyde" xref: RHEA:23352 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003868 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: reactome:R-HSA-71163 "p-hydroxyphenylpyruvate + O2 => homogentisate + CO2" xref: RHEA:16189 xref: UM-BBD_reactionID:r0298 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003870 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycine + H(+) + succinyl-CoA = 5-aminolevulinate + CO(2) + CoA." [EC:2.3.1.37, RHEA:12921] synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: KEGG:R00830 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: reactome:R-HSA-189442 "ALAS condenses SUCC-CoA and Gly to form dALA" xref: RHEA:12921 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0003871 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = L-methionine + tetrahydropteroyltri-L-glutamate." [EC:2.1.1.14, RHEA:21196] synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: KEGG:R04405 xref: MetaCyc:HOMOCYSMET-RXN xref: RHEA:21196 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: GO:0003872 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose-6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: MetaCyc:6PFRUCTPHOS-RXN xref: reactome:R-HSA-70467 "D-fructose 6-phosphate + ATP => D-fructose 1,6-bisphosphate + ADP" xref: RHEA:16109 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003873 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + ATP = beta-D-fructose 2,6-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.105, RHEA:15653] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: KEGG:R02732 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: reactome:R-HSA-71802 "D-fructose 6-phosphate + ATP => D-fructose 2,6-bisphosphate + ADP" xref: RHEA:15653 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003874 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydroneopterin 3'-triphosphate = 6-pyruvoyl-5,6,7,8-tetrahydropterin + H(+) + triphosphate." [EC:4.2.3.12, RHEA:22048] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: KEGG:R04286 xref: MetaCyc:4.2.3.12-RXN xref: reactome:R-HSA-1474184 "DHNTP is dephosphorylated by PTPS to PTHP" xref: RHEA:22048 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003875 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN xref: RHEA:20784 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003876 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: MetaCyc:AMP-DEAMINASE-RXN xref: reactome:R-HSA-76590 "AMP + H2O => IMP + NH4+ (AMPD)" xref: RHEA:14777 is_a: GO:0047623 ! adenosine-phosphate deaminase activity [Term] id: GO:0003877 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN xref: RHEA:16577 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003878 name: ATP citrate synthase activity namespace: molecular_function alt_id: GO:0046913 def: "Catalysis of the reaction: acetyl-CoA + ADP + H(+) + oxaloacetate + phosphate = ATP + citrate + CoA." [EC:2.3.3.8, RHEA:21160] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: KEGG:R00352 xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN xref: MetaCyc:PWY-5172 xref: reactome:R-HSA-75848 "ACLY tetramer transforms CIT to Ac-CoA" xref: RHEA:21160 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003879 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN xref: RHEA:18473 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003880 name: protein C-terminal carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0003881 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol + CDP-diacylglycerol = 1-phosphatidyl-1D-myo-inositol + CMP + H(+)." [EC:2.7.8.11, RHEA:11580] synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: KEGG:R01802 xref: MetaCyc:2.7.8.11-RXN xref: reactome:R-HSA-1482976 "CDP-DAG is converted to PI by CDIPT" xref: RHEA:11580 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN xref: RHEA:16913 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003883 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: MetaCyc:CTPSYN-RXN xref: reactome:R-HSA-504054 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS2]" xref: reactome:R-HSA-73647 "UTP + glutamine + ATP + H2O => CTP + glutamate + ADP + orthophosphate [CTPS]" xref: RHEA:16597 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003884 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + hydrogen peroxide." [EC:1.4.3.3] synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN xref: reactome:R-HSA-389821 "glycine + O2 => glyoxylate + H2O2 + NH4+" xref: RHEA:21816 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0003885 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O(2) = dehydro-D-arabinono-1,4-lactone + H(2)O(2) + H(+)." [EC:1.1.3.37, RHEA:23756] synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: KEGG:R02715 xref: MetaCyc:1.1.3.37-RXN xref: RHEA:23756 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003886 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function alt_id: GO:0008326 def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group." [EC:2.7.7.7, GOC:vw, ISBN:0198547684] synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: reactome:R-HSA-110311 "POLZ extends translesion synthesis" xref: reactome:R-HSA-110317 "Insertion of correct bases opposite the lesion by POLH" xref: reactome:R-HSA-110319 "Elongation by POLH" xref: reactome:R-HSA-110368 "POLD,POLE-mediated DNA strand displacement synthesis" xref: reactome:R-HSA-111253 "POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site" xref: reactome:R-HSA-164505 "Synthesis of full-length duplex viral DNA with a discontinuous plus strand" xref: reactome:R-HSA-164513 "3' PPT-primed initiation of plus-strand DNA synthesis" xref: reactome:R-HSA-174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: reactome:R-HSA-174444 "Formation of C-strand Okazaki fragments" xref: reactome:R-HSA-5358579 "DNA polymerase delta polymerizes DNA across single stranded gap" xref: reactome:R-HSA-5649723 "POLB incorporates a single nucleotide in place of excised AP residue in NEIL1,NEIL2-mediated AP site resolution" xref: reactome:R-HSA-5649883 "POLB-mediated DNA strand displacement synthesis" xref: reactome:R-HSA-5653840 "POLD,POLE complete replication of damaged DNA after TLS" xref: reactome:R-HSA-5655892 "POLK incorporates dNMP opposite to damaged DNA base" xref: reactome:R-HSA-5655965 "POLK and POLZ cooperate in elongation of mispaired primer termini" xref: reactome:R-HSA-5656148 "POLI incorporates dNMP opposite to damaged DNA base" xref: reactome:R-HSA-5656158 "POLZ elongates POLI-incorporated dNMP" xref: reactome:R-HSA-5687360 "POLL or POLM extends aligned DNA DSB ends to fill gaps" xref: reactome:R-HSA-5687640 "POLQ extends annealed 3'-ssDNA overhangs in MMEJ" xref: reactome:R-HSA-5691001 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in GG-NER" xref: reactome:R-HSA-5693593 "D-loop extension by DNA polymerases" xref: reactome:R-HSA-6782208 "Repair DNA synthesis of ~27-30 bases long patch by POLD, POLE or POLK in TC-NER" xref: reactome:R-HSA-6786166 "Translesion synthesis across unhooked ICL by POLN" xref: reactome:R-HSA-68950 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin" xref: reactome:R-HSA-69116 "Formation of Okazaki fragments" xref: reactome:R-HSA-73932 "Resynthesis of excised residue by POLB" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003892 name: obsolete proliferating cell nuclear antigen namespace: molecular_function alt_id: GO:0005661 def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "PCNA" EXACT [] synonym: "proliferating cell nuclear antigen" EXACT [] is_obsolete: true [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases." [GOC:mah, GOC:mcc, ISBN:0716720094, PMID:26184436] xref: EC:2.7.7 is_a: GO:0003899 ! DNA-directed 5'-3' RNA polymerase activity [Term] id: GO:0003899 name: DNA-directed 5'-3' RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6, GOC:pf] synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase activity" BROAD [] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: reactome:R-HSA-111264 "Addition of nucleotides between position +11 and +30" xref: reactome:R-HSA-167113 "Addition of the fourth nucleotide on the nascent HIV-1 transcript: Second Transition" xref: reactome:R-HSA-167115 "Addition of nucleotides between position +11 and +30 on HIV-1 transcript" xref: reactome:R-HSA-167117 "Addition of nucleotides 10 and 11 on the growing HIV-1 transcript: Third Transition" xref: reactome:R-HSA-167121 "Addition of the third nucleotide on the nascent HIV-1 transcript" xref: reactome:R-HSA-167136 "Addition of nucleotides 5 through 9 on the growing HIV-1 transcript" xref: reactome:R-HSA-174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: reactome:R-HSA-203901 "Pol II mediated transcription of microRNA genes" xref: reactome:R-HSA-427366 "Transcription of intergenic spacer of the rRNA gene" xref: reactome:R-HSA-452392 "Transcription of POU5F1 (OCT4)" xref: reactome:R-HSA-452838 "Expression of NANOG" xref: reactome:R-HSA-452894 "Expression of SOX2" xref: reactome:R-HSA-480301 "Expression of EPAS1 (HIF2A)" xref: reactome:R-HSA-480520 "Expression of SALL4" xref: reactome:R-HSA-5601926 "RNA polymerase II polymerizes primary piRNA transcript" xref: reactome:R-HSA-6781824 "Active RNA Pol II complex transcribes lesion-containing DNA template" xref: reactome:R-HSA-68913 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin" xref: reactome:R-HSA-74986 "Elongation of pre-rRNA transcript" xref: reactome:R-HSA-75850 "Addition of the third nucleotide on the nascent transcript" xref: reactome:R-HSA-75869 "Addition of the fourth nucleotide on the Nascent Transcript: Second Transition" xref: reactome:R-HSA-75873 "Addition of Nucleotides 5 through 9 on the growing Transcript" xref: reactome:R-HSA-76576 "Addition of nucleotides 10 and 11 on the growing transcript: Third Transition" is_a: GO:0034062 ! 5'-3' RNA polymerase activity [Term] id: GO:0003900 name: obsolete DNA-directed RNA polymerase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. synonym: "DNA-directed RNA polymerase I activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003901 name: obsolete DNA-directed RNA polymerase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. synonym: "DNA-directed RNA polymerase II activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003902 name: obsolete DNA-directed RNA polymerase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. synonym: "DNA-directed RNA polymerase III activity" EXACT [] is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003904 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light." [EC:4.1.99.3] synonym: "CPD photolyase activity" EXACT [PMID:16302973] synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the reaction: DNA with alkylated base + H2O = DNA with abasic site + alkylated base. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar to remove an alkylated base, leaving an apyrimidinic or apurinic site." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0003906 name: DNA-(apurinic or apyrimidinic site) endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER)." [Wikipedia:AP_endonuclease] synonym: "abasic deoxyendoribonuclease activity" EXACT [] synonym: "AP deoxyendoribonuclease activity" EXACT [] synonym: "apurinic deoxyendoribonuclease activity" EXACT [] synonym: "apurinic/apyrimidinic endodeoxyribonuclease activity" EXACT [] synonym: "apyrimidinic deoxyendoribonuclease activity" EXACT [] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] synonym: "UV endonuclease" BROAD [] xref: reactome:R-HSA-110375 "Excision of the abasic sugar phosphate (5'dRP) residue at the single strand break" xref: reactome:R-HSA-5649711 "NEIL1,NEIL2 incises DNA strand 5' to the AP site" xref: reactome:R-HSA-5649725 "POLB excises the NEIL1,NEIL2-bound AP site (5'dRP)" is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003908 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: reactome:R-HSA-73892 "MGMT/hAGT mediated DNA Damage Reversal" is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0003909 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another. This reaction requires an energy source such as ATP or NAD+." [ISBN:0716720094] xref: reactome:R-HSA-174456 "Joining of adjacent Okazaki fragments of the C-strand" xref: reactome:R-HSA-175258 "2-LTR formation due to circularization of viral DNA" xref: reactome:R-HSA-5358592 "DNA ligase I ligates single stranded nick in double stranded DNA" xref: reactome:R-HSA-5649734 "LIG3 ligates NEIL1,NEIL2-generated single strand break" xref: reactome:R-HSA-5651789 "LIG1 bound to POLB ligates SSB" xref: reactome:R-HSA-5651805 "LIG1 bound to APEX1 and PCNA ligates SSB" xref: reactome:R-HSA-5687675 "LIG3 ligates remaining SSBs in MMEJ" xref: reactome:R-HSA-5690997 "Ligation of newly synthesized repair patch to incised DNA in GG-NER" xref: reactome:R-HSA-5693604 "XRCC4:LIG4 ligates DNA DSB ends during NHEJ" xref: reactome:R-HSA-6782227 "Ligation of newly synthesized repair patch to incised DNA in TC-NER" xref: reactome:R-HSA-69173 "Joining of adjacent Okazaki fragments" xref: reactome:R-HSA-73931 "LIG3-mediated DNA ligation via the single-nucleotide replacement pathway" is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003910 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: MetaCyc:DNA-LIGASE-ATP-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003911 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: MetaCyc:DNA-LIGASE-NAD+-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003912 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003913 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] xref: EC:4.1.99 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0016830 ! carbon-carbon lyase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003914 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] xref: EC:4.1.99.13 xref: MetaCyc:RXN-10771 is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] xref: MetaCyc:5.99.1.2-RXN is_a: GO:0016853 ! isomerase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0003917 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003918 name: DNA topoisomerase type II (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] synonym: "DNA topoisomerase IV activity" EXACT [] synonym: "DNA topoisomerase type II activity" RELATED [] synonym: "topoisomerase" BROAD [EC:5.99.1.3] synonym: "topoisomerase II" RELATED [] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] xref: EC:5.99.1.3 xref: MetaCyc:5.99.1.3-RXN xref: Wikipedia:Type_II_topoisomerase is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0061505 ! DNA topoisomerase II activity [Term] id: GO:0003919 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2, RHEA:17237] synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: KEGG:R00161 xref: MetaCyc:FADSYN-RXN xref: reactome:R-HSA-196929 "FLAD1 phosphorylates FMN" xref: RHEA:17237 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003920 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + NADP(+) + NH(4)(+) = GMP + 2 H(+) + NADPH." [EC:1.7.1.7, RHEA:17185] comment: Note that this function was formerly EC:1.6.6.8. synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: KEGG:R01134 xref: MetaCyc:GMP-REDUCT-RXN xref: reactome:R-HSA-514604 "GMP + NADPH + H+ => IMP + NADP+ + NH4+ (GMPR,GMPR2)" xref: RHEA:17185 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0003921 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + XMP + NH4(+) = AMP + diphosphate + GMP + 2H(+)." [RHEA:18301] xref: MetaCyc:GMP-SYN-NH3-RXN xref: RHEA:18301 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds relationship: part_of GO:0003922 ! GMP synthase (glutamine-hydrolyzing) activity [Term] id: GO:0003922 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate + 2H(+)." [RHEA:11680] synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: MetaCyc:GMP-SYN-GLUT-RXN xref: reactome:R-HSA-73792 "XMP + L-Glutamine + ATP + H2O => GMP + L-Glutamate + AMP + pyrophosphate" xref: RHEA:11680 xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003923 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309] xref: EC:3 xref: reactome:R-HSA-162836 "uPAR precursor + acyl-GPI -> uPAR-acyl-GPI + uPAR propeptide" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: reactome:R-HSA-1445143 "RAB8A,10,13,14 hydrolyze GTP" xref: reactome:R-HSA-1458485 "RALA hydrolyzes GTP" xref: reactome:R-HSA-156923 "Hydrolysis of eEF1A:GTP" xref: reactome:R-HSA-164381 "G alpha (s) auto-inactivates by hydrolysing GTP to GDP" xref: reactome:R-HSA-165055 "Hydrolysis of Ran:GTP to Ran:GDP" xref: reactome:R-HSA-167415 "G-protein alpha subunit is inactivated" xref: reactome:R-HSA-170666 "Adenylate cyclase increases the GTPase activity of G alpha-olf" xref: reactome:R-HSA-170685 "Adenylaye cyclase increases the GTPase activity of G alpha-olf" xref: reactome:R-HSA-170686 "Adenylate cyclase increases the GTPase activity of Gi alpha" xref: reactome:R-HSA-177501 "Endocytosis (internalization) of clathrin-coated vesicle" xref: reactome:R-HSA-203973 "Vesicle budding" xref: reactome:R-HSA-2130641 "Translocation of TGN-lysosome vesicle to lysosome" xref: reactome:R-HSA-2130725 "Internalization of MHC II:Ii clathrin coated vesicle" xref: reactome:R-HSA-2584246 "GNAT1-GTP hydrolyses its bound GTP to GDP" xref: reactome:R-HSA-380979 "RHEB in mTORC1:RHEB:GTP hydrolyses GTP" xref: reactome:R-HSA-392133 "G alpha (z) auto-inactivates by hydrolysing GTP to GDP" xref: reactome:R-HSA-392212 "G alpha (i) auto-inactivates by hydrolysing GTP to GDP" xref: reactome:R-HSA-418574 "G alpha (12/13) auto-inactivates by hydrolysing GTP to GDP" xref: reactome:R-HSA-418582 "G alpha (q) auto-inactivates by hydrolysing GTP to GDP" xref: reactome:R-HSA-421835 "trans-Golgi Network Vesicle Scission" xref: reactome:R-HSA-428941 "P2Y purinoceptor 1 activates MAP kinase p38 alpha" xref: reactome:R-HSA-432707 "trans-Golgi Network Lysosomal Vesicle Scission" xref: reactome:R-HSA-5333615 "80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTP is hydrolysed to 80S:Met-tRNAi:mRNA:SECISBP2:Sec and EEFSEC:GDP by EEFSEC" xref: reactome:R-HSA-5389839 "39S subunit binds 28S subunit:mRNA:fMet-tRNA" xref: reactome:R-HSA-5389842 "TUFM hydrolyzes GTP and TUFM:GDP dissociates from 55S ribosome" xref: reactome:R-HSA-5419273 "Hydrolysis of GTP and dissociation of 28S and 39S subunits" xref: reactome:R-HSA-5419279 "Translocation of peptidyl-tRNA from A-site to P-site (and translocation of 55S ribosome by 3 bases along mRNA)" xref: reactome:R-HSA-555065 "Formation of clathrin coated vesicle" xref: reactome:R-HSA-5623513 "ASAP1 stimulates GTPase activity of ARF4" xref: reactome:R-HSA-5638006 "ARL3 hydrolyzes GTP" xref: reactome:R-HSA-5658231 "RAS GAPs stimulate RAS GTPase activity" xref: reactome:R-HSA-5665809 "SRGAP2 stimulates RAC1 GTP-ase activity and ends FMNL1-mediated elongation of actin filaments" xref: reactome:R-HSA-5672017 "Rheb in the mTORC1 complex hydrolyses GTP" xref: reactome:R-HSA-5694527 "Loss of SAR1B GTPase" xref: reactome:R-HSA-6807877 "ARFGAPs stimulate ARF GTPase activity" xref: reactome:R-HSA-6814833 "TBC1D20 stimulates GTPase activity of RAB1, resulting in hydrolysis of GTP" xref: reactome:R-HSA-8847534 "RAB43 hydrolyses GTP" xref: reactome:R-HSA-8847883 "CYTH proteins stimulate ARF1 GTPase activity" xref: reactome:R-HSA-8849082 "ARHGAP35 stimulates RHOA GTPase activity" xref: reactome:R-HSA-8854173 "TBC RabGAPs accelerate GTP hydrolysis by RAB35" xref: reactome:R-HSA-8854255 "TBC1D2A accelerates GTP hydrolysis by RAB7" xref: reactome:R-HSA-8854329 "TBC1D15 accelerates GTP hydrolysis by RAB7" xref: reactome:R-HSA-8854604 "TBC1D16 accelerates GTP hydrolysis by RAB4A" xref: reactome:R-HSA-8854612 "TBC1D25 accelerates GTP hydrolysis by RAB33B" xref: reactome:R-HSA-8868661 "Dynamin-mediated GTP hydrolysis promotes vesicle scission" xref: reactome:R-HSA-8981353 "RASA1 stimulates RAS GTPase activity" xref: reactome:R-HSA-8982020 "G alpha (i)i1/i2/i3 in G (i):RGS complex is inactivated" xref: reactome:R-HSA-8982021 "G alpha (z) in G alpha (z):RGS complex is inactivated" xref: reactome:R-HSA-8982025 "G alpha (q) in G (q):RGS complex is inactivated" xref: reactome:R-HSA-983422 "Disassembly of COPII coated vesicle" xref: RHEA:19669 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003925 name: obsolete small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] comment: This term was made obsolete because it represents a gene product and contains cellular component information. synonym: "small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 [Term] id: GO:0003926 name: obsolete ARF small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "ARF small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003927 name: obsolete heterotrimeric G-protein GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] comment: This term was made obsolete because it represents a cellular component. synonym: "heterotrimeric G-protein GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0003928 name: obsolete RAB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAB small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003929 name: obsolete RAN small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAN small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006606 [Term] id: GO:0003930 name: obsolete RAS small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "RAS small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 [Term] id: GO:0003931 name: obsolete Rho small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "Rho small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0007010 [Term] id: GO:0003932 name: obsolete SAR small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. synonym: "SAR small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0046903 [Term] id: GO:0003933 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [EC:3.5.4.16, EC:3.5.4.25, EC:3.5.4.29, GOC:curators] is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003934 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = formate + 7,8-dihydroneopterin 3'-triphosphate." [EC:3.5.4.16] synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: KEGG:R00424 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN xref: reactome:R-HSA-1474146 "GCH1 reduces GTP to dihydroneopterin triphosphate" xref: RHEA:17473 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003935 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H(2)O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + diphosphate + formate + 3 H(+)." [EC:3.5.4.25, RHEA:23704] synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: KEGG:R00425 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN xref: RHEA:23704 is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003936 name: obsolete hydrogen-transporting two-sector ATPase activity namespace: molecular_function alt_id: GO:0004006 alt_id: GO:0008729 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "hydrogen-transporting two-sector ATPase activity" EXACT [] synonym: "proton-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: reactome:R-HSA-73797 "FAICAR => IMP + H2O" xref: RHEA:18445 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003938 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: MetaCyc:IMP-DEHYDROG-RXN xref: reactome:R-HSA-73794 "IMP + H2O + NAD+ => XMP + NADH + H+ [IMPDH1,2]" xref: RHEA:11708 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003939 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN xref: reactome:R-HSA-5652195 "SORD oxidizes D-sorbitol to Fru" xref: RHEA:10160 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003940 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in dermatan sulfate." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: MetaCyc:3.2.1.76-RXN xref: reactome:R-HSA-1678716 "IDUA hydrolyses Heparan sulfate chain(1)" xref: reactome:R-HSA-1793186 "IDUA) hydrolyses the unsulfated alpha-L-iduronosidic link in DS" xref: reactome:R-HSA-2090037 "IDUA hydrolyses Heparan sulfate chain(6)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003941 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: MetaCyc:4.3.1.17-RXN xref: RHEA:19169 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0003942 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN xref: RHEA:21588 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0003943 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: MetaCyc:3.1.6.12-RXN xref: reactome:R-HSA-1606789 "ARSB hydrolyses DS" xref: reactome:R-HSA-1793207 "ARSB hydrolyses C4S/C6S chains" xref: Wikipedia:Arylsulfatase_B is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0003944 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0003945 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-GalT" RELATED [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine beta-(1,4)-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN xref: RHEA:17745 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003947 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: MetaCyc:2.4.1.92-RXN xref: reactome:R-HSA-8856223 "B4GALNT1 dimer transfers GalNAc from UDP-GalNAc to GM3 and GD3 gangliosides" xref: RHEA:12588 is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0003948 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+)." [EC:3.5.1.26, RHEA:11544] synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: KEGG:R03421 xref: MetaCyc:3.5.1.26-RXN xref: RHEA:11544 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003949 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide = 5-[(5-phospho-1-deoxy-D-ribulos-1-ylimino)methylamino]-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide." [EC:5.3.1.16, RHEA:15469] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: KEGG:R04640 xref: MetaCyc:PRIBFAICARPISOM-RXN xref: RHEA:15469 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0003950 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN xref: reactome:R-HSA-2187325 "PARP1 ADP-ribosylates SMAD3 and SMAD4" xref: reactome:R-HSA-3640858 "Tankyrase ADP-ribosylates AXIN" xref: reactome:R-HSA-5651723 "PARP1,PARP2 dimers bound to FEN1 and POLB autoPARylate" xref: reactome:R-HSA-5687653 "PARP1,PARP2 dimers bound to MMEJ sites autoPARylate" xref: reactome:R-HSA-5688276 "SIRT4 transfers ADPRib to GLUD" xref: reactome:R-HSA-8938073 "PARPs transfer ADP-D-ribose to proteins (poly(ADP-ribosyl)ation)" xref: reactome:R-HSA-8948800 "TNKS and TNKS2 PARylate PTEN" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003951 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD(+) = ADP + 2 H(+) + NADP(+)." [EC:2.7.1.23, RHEA:18629] synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: KEGG:R00104 xref: MetaCyc:NAD-KIN-RXN xref: reactome:R-HSA-197198 "NADK:Zn2+ tetramer phosphorylates NAD+ to NADP+" xref: reactome:R-HSA-8955030 "NADK2 dimer phosphorylates NAD+ to NADP+" xref: RHEA:18629 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0003952 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: MetaCyc:NAD-SYNTH-GLN-RXN xref: reactome:R-HSA-197271 "NADSYN1 hexamer amidates NAAD to NAD+" xref: RHEA:24384 xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003953 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [GOC:dph, GOC:pad, GOC:PARL, GOC:pde, PMID:11866528, PMID:7805847] synonym: "NAD nucleosidase activity" EXACT [] xref: reactome:R-HSA-8870346 "BST1 hydrolyzes NAD+ to yield NAM and ADP-ribose" xref: reactome:R-HSA-8938076 "CD38 hydrolyses NAD+ to NAM and ADP-ribose" xref: RHEA:16301 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN xref: RHEA:11356 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003955 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a hydroquinone." [EC:1.6.5.2] synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN xref: UM-BBD_reactionID:r0227 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003956 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: MetaCyc:2.4.2.31-RXN xref: reactome:R-HSA-1972385 "ADP-Ribosylation of HNP-1" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003957 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+, driving the transfer of a solute or solutes from one side of a membrane to the other. In the course of the reaction (left to right) one H atom is transferred from inside the cell to outside. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf, MetaCyc:PYRNUTRANSHYDROGEN-RXN] synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity is_a: GO:0015078 ! proton transmembrane transporter activity [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN xref: reactome:R-HSA-76494 "POR reduces CYP450:Fe3+ to CYP450:Fe2+" is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0003959 name: NADPH dehydrogenase activity namespace: molecular_function alt_id: GO:0008468 alt_id: GO:0016660 def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.1] synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN xref: reactome:R-HSA-9018867 "5-HEDH dehydrogenates 5(S)-Hp-18(S)-HpEPE to 18(S)-RvE2" xref: reactome:R-HSA-9018901 "5-HEDH dehydrogenates 5(S)-Hp-18(R)-HpEPE to 18(R)-RvE2" xref: reactome:R-HSA-9027625 "5-HEDH dehydrogenates 7-HDPAn-3 to 7-oxo-DPAn-3" xref: reactome:R-HSA-9027631 "5-HEDH dehydrogenates 7-HDHA to 7-oxo-DHA" xref: reactome:R-HSA-9027632 "5-HEDH dehydrogenates 5-HEPE to 5-oxo-EPA" xref: UM-BBD_enzymeID:e0523 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0003960 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN xref: reactome:R-HSA-6799722 "TP53I3 oxidoreductase generates unstable semiquinones" is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0003961 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function alt_id: GO:0019282 def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate. Also reacts with other thiols and H2S, producing homocysteine or thioethers." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. synonym: "4.2.99.9" RELATED [] synonym: "L-methionine anabolism, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [] synonym: "L-methionine formation, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "L-methionine synthesis, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "methionine biosynthetic process, direct, from O-acetyl-L-homoserine" EXACT [GOC:mah] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN xref: RHEA:10048 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003962 name: cystathionine gamma-synthase activity namespace: molecular_function alt_id: GO:0000505 def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN xref: RHEA:20397 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003963 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0003964 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: reactome:R-HSA-164504 "Synthesis of minus strand strong stop DNA (-sssDNA)" xref: reactome:R-HSA-164520 "Minus strand DNA synthesis resumes" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003966 name: obsolete RNA-directed DNA polymerase, transposon encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. synonym: "RNA-directed DNA polymerase, transposon encoded" EXACT [] is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003967 name: obsolete RNA-directed DNA polymerase, group II intron encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. synonym: "RNA-directed DNA polymerase, group II intron encoded" EXACT [] is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003968 name: RNA-directed 5'-3' RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); uses an RNA template, i.e. the catalysis of RNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time." [EC:2.7.7.48, GOC:mah, GOC:pf] synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA-directed RNA polymerase activity" BROAD [] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: reactome:R-HSA-168280 "Priming and Initiation of Transcription" xref: reactome:R-HSA-168301 "Polyadenylation and Termination" xref: reactome:R-HSA-168334 "Elongation of viral mRNA" xref: reactome:R-HSA-192624 "cRNA Extension" xref: reactome:R-HSA-192832 "Initiation of cRNA Synthesis" xref: reactome:R-HSA-192851 "vRNA Extension" xref: reactome:R-HSA-192916 "Initiation of vRNA Synthesis" is_a: GO:0034062 ! 5'-3' RNA polymerase activity [Term] id: GO:0003969 name: obsolete RNA editase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a biological process. synonym: "RNA editase activity" EXACT [] is_obsolete: true [Term] id: GO:0003972 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide(n) + ribonucleotide(m) = AMP + diphosphate + ribonucleotide(n+m)." [EC:6.5.1.3] synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: MetaCyc:RNA-LIGASE-ATP-RXN xref: reactome:R-HSA-5696816 "tRNA ligase complex ligates tRNA exons" is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0003973 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + hydrogen peroxide." [EC:1.1.3.15] synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003974 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN xref: RHEA:20517 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN xref: reactome:R-HSA-446191 "Addition of N-acetyl-D-glucosamine to Dolichyl phosphate" xref: RHEA:13289 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003976 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003977 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate + UTP = diphosphate + UDP-N-acetyl-alpha-D-glucosamine." [EC:2.7.7.23, RHEA:13509] synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: KEGG:R00416 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN xref: reactome:R-HSA-446204 "GlcNAc1P is dephosphorylated to UDP-N-acetyl-glucosamine" xref: RHEA:13509 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0003978 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: MetaCyc:UDPGLUCEPIM-RXN xref: reactome:R-HSA-70369 "GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc" xref: RHEA:22168 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003979 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 NAD(+) + UDP-alpha-D-glucose = 3 H(+) + 2 NADH + UDP-alpha-D-glucuronate." [EC:1.1.1.22, RHEA:23596] xref: EC:1.1.1.22 xref: KEGG:R00286 xref: MetaCyc:UGD-RXN xref: reactome:R-HSA-173597 "UDP-glucose is oxidised to UDP-glucuronate" xref: RHEA:23596 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003980 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [GOC:al, PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1 xref: reactome:R-HSA-548884 "UGGT1,2 transfers glucose from DbGP to (un)folded protein:(GlcNAc)2 (Man)8b" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003983 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + UTP = diphosphate + UDP-D-glucose." [EC:2.7.7.9, RHEA:19889] synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: KEGG:R00289 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: reactome:R-HSA-70286 "UTP + D-glucose 1-phosphate <=> pyrophosphate + UDP-glucose" xref: RHEA:19889 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0003984 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: MetaCyc:ACETOLACTSYN-RXN xref: RHEA:20504 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0003985 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: reactome:R-HSA-70844 "alpha-methyl-acetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA" xref: reactome:R-HSA-73916 "2 acetyl-CoA <=> acetoacetyl-CoA + CoA" xref: reactome:R-HSA-74181 "acetoacetyl-CoA + CoA <=> 2 acetyl-CoA" xref: reactome:R-HSA-8848215 "ACAT2 condenses 2 Ac-CoA to form ACA-CoA" xref: RHEA:21036 xref: UM-BBD_enzymeID:e0144 is_a: GO:0003988 ! acetyl-CoA C-acyltransferase activity is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0003986 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+)." [EC:3.1.2.1, RHEA:20289] synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: KEGG:R00227 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN xref: reactome:R-HSA-2066779 "Conversion of DHA-CoA to docosahexaenoic acid (DHA)" xref: reactome:R-HSA-390304 "acetyl-CoA + H2O => acetate + CoASH" xref: RHEA:20289 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003987 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: reactome:R-HSA-449911 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [mitochondrial]" xref: reactome:R-HSA-71735 "acetate + CoA + ATP => acetyl-CoA + AMP + pyrophosphate [cytosolic]" xref: reactome:R-HSA-8875071 "ACSS3 ligates CoA to CH3COO-" xref: RHEA:23176 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003988 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: reactome:R-HSA-390250 "3-ketohexacosanoyl-CoA + CoASH => tetracosanoyl-CoA + acetyl-CoA" xref: reactome:R-HSA-77271 "3-Oxotetradecanoyl-CoA+CoA-SH<=>Lauroyl-CoA" xref: reactome:R-HSA-77304 "3-Oxopalmitoyl-CoA+CoA-SH<=>myristoyl-CoA" xref: reactome:R-HSA-77309 "3-Oxododecanoyl-CoA+CoA-SH<=>Decanoyl-CoA" xref: reactome:R-HSA-77321 "3-Oxohexanoyl-CoA+CoA-SH<=>Butanoyl-CoA" xref: reactome:R-HSA-77329 "3-Oxooctanoyl-CoA+CoA-SH<=>Hexanoyl-CoA" xref: reactome:R-HSA-77340 "3-Oxodecanoyl-CoA+CoA-SH<=>Octanoyl-CoA" xref: reactome:R-HSA-8874745 "ACAA2 tetramer transfers acyl group from Ac-CoA to acyl-CoA forming 3OA-CoA and CoA-SH" xref: RHEA:21564 xref: UM-BBD_reactionID:r1051 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0003989 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: reactome:R-HSA-200555 "acetyl-CoA + bicarbonate + ATP => malonyl-CoA + H2O + ADP + orthophosphate" xref: reactome:R-HSA-75851 "Btn-ACACA:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" xref: reactome:R-HSA-8876889 "Btn-ACACB:2Mn2+ polymer carboxylates Ac-CoA to form Mal-CoA" xref: RHEA:11308 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: goslim_chembl synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN xref: reactome:R-HSA-372519 "AcCho is hydrolyzed to Cho and acetate by ACHE" xref: RHEA:17561 is_a: GO:0004104 ! cholinesterase activity [Term] id: GO:0003991 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate-5-phosphate." [EC:2.7.2.8] synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: MetaCyc:ACETYLGLUTKIN-RXN xref: RHEA:14629 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0003992 name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity namespace: molecular_function alt_id: GO:0047318 def: "Catalysis of the reaction: 2-oxoglutarate + N(2)-acetyl-L-ornithine = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11, RHEA:18049] synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" BROAD [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: KEGG:R02283 xref: MetaCyc:ACETYLORNTRANSAM-RXN xref: RHEA:18049 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: reactome:R-HSA-196950 "2xTRAP hydrolyzes FMN to RIB" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = isocitrate. The reaction occurs in two steps: (1) citrate = cis-aconitate + H2O, (2) cis-aconitate + H2O = isocitrate. This reaction is the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3, GOC:pde, GOC:vw] comment: This is a process composed of two reactions represented by the terms 'GO:0052632 : citrate hydro-lyase (cis-aconitate-forming) activity' and 'GO:0052633 : isocitrate hydro-lyase (cis-aconitate-forming) activity'. synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: reactome:R-HSA-450975 "isocitrate <=> citrate" xref: reactome:R-HSA-5690911 "ACO1:4Fe-4S isomerises CIT to ISCIT" xref: reactome:R-HSA-70971 "citrate <=> isocitrate" xref: RHEA:10336 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003995 name: acyl-CoA dehydrogenase activity namespace: molecular_function alt_id: GO:0019109 def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.3 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN xref: reactome:R-HSA-109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: reactome:R-HSA-5695980 "ACAD10 dehydrogenates S-2MPDA-CoA" xref: reactome:R-HSA-5695989 "ACAD11 dehydrogenates BH-CoA" xref: reactome:R-HSA-70800 "alpha-methylbutyryl-CoA + FAD => tiglyl-CoA + FADH2" xref: reactome:R-HSA-70859 "isobutyryl-CoA + FAD => methacrylyl-CoA + FADH2" xref: reactome:R-HSA-77263 "lauroyl-CoA+FAD<=>2-trans-Dodecenoyl-CoA+FADH2" xref: reactome:R-HSA-77274 "myristoyl-CoA+FAD<=>trans-Tetradec-2-enoyl-CoA+FADH2" xref: reactome:R-HSA-77299 "palmitoyl-CoA+FAD<=>trans-Hexadec-2-enoyl-CoA+FADH2" xref: reactome:R-HSA-77319 "Butanoyl-CoA+FAD<=>Crotonoyl-CoA+FADH2" xref: reactome:R-HSA-77327 "Hexanoyl-CoA+FAD<=>trans-Hex-2-enoyl-CoA+FADH2" xref: reactome:R-HSA-77338 "Octanoyl-CoA+FAD<=>trans-Oct-2-enoyl-CoA+FADH2" xref: reactome:R-HSA-77345 "Decanoyl-CoA+FAD<=>trans-Dec-2-enoyl-CoA+FADH2" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0003996 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain carboxylic acids have chain lengths of C13 to C22." [CHEBI:15904, EC:6.2.1.3, GOC:mah] xref: EC:6.2.1.3 xref: reactome:R-HSA-5696004 "ACSF2 ligates CoA-SH to MCFA" is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003997 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + hydrogen peroxide." [EC:1.3.3.6] synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: MetaCyc:ACYL-COA-OXIDASE-RXN xref: reactome:R-HSA-192335 "25(S) THCA-CoA is dehydrogenated to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA (THCA-CoA)" xref: reactome:R-HSA-193369 "25(S) DHCA-CoA is dehydrogenated to 25(S) 3alpha,7alpha-dihydroxy-5beta-cholest-24-enoyl-CoA" xref: reactome:R-HSA-2066787 "Oxidation of tetracosapentaenoyl-CoA to delta2-tetracosaheptaenoyl-CoA" xref: reactome:R-HSA-390256 "hexacosanoyl-CoA + O2 => trans-2,3-dehydrohexacosanoyl-CoA + H2O2" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0003998 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: MetaCyc:ACYLPHOSPHATASE-RXN xref: RHEA:14965 is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0003999 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: reactome:R-HSA-74213 "Adenine + PRPP => AMP + PPi" xref: RHEA:16609 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0004000 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: MetaCyc:ADENODEAMIN-RXN xref: reactome:R-HSA-2161187 "N6-methyl-AMP + H2O => IMP + methylamine" xref: reactome:R-HSA-2161195 "abacavir monophosphate + H2O => carbovir monophosphate + cyclopropylamine" xref: reactome:R-HSA-5693346 "CECRI deaminates Ade-Rib to Ino" xref: reactome:R-HSA-74241 "(2'-deoxy)adenosine + H2O => (2'-deoxy)inosine + NH4+ (ADA)" xref: RHEA:24408 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004001 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: reactome:R-HSA-109624 "(2'-deoxy)adenosine + ATP => (d)AMP + ADP (ADK)" xref: RHEA:20824 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004003 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] xref: reactome:R-HSA-5693589 "D-loop dissociation and strand annealing" xref: reactome:R-HSA-6782131 "RNA Pol II backtracking in TC-NER" is_a: GO:0003678 ! DNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0004004 name: ATP-dependent RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] is_a: GO:0003724 ! RNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008186 ! RNA-dependent ATPase activity [Term] id: GO:0004005 name: obsolete plasma membrane cation-transporting ATPase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "plasma membrane cation-transporting ATPase" EXACT [] is_obsolete: true consider: GO:0005886 consider: GO:0019829 [Term] id: GO:0004007 name: obsolete heavy metal-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal-exporting ATPase activity" EXACT [] is_obsolete: true consider: GO:0046873 [Term] id: GO:0004008 name: copper-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) -> ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] xref: EC:3.6.3.4 xref: MetaCyc:3.6.3.4-RXN xref: reactome:R-HSA-6803545 "ATP7A transports cytosolic Cu2+ to phagosomal lumen" xref: reactome:R-HSA-936802 "ATP7A transports cytosolic Cu2+ to extracellular region" xref: RHEA:10377 is_a: GO:0043682 ! copper-transporting ATPase activity [Term] id: GO:0004009 name: obsolete ATP-binding cassette (ABC) transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ATP-binding cassette (ABC) transporter activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0004012 name: phospholipid-translocating ATPase activity namespace: molecular_function alt_id: GO:0008557 def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] synonym: "aminophospholipid-transporting ATPase" RELATED [] synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] synonym: "flippase activity" BROAD [EC:3.6.3.1] synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospholipid translocating ATPase activity" EXACT [] synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospolipid flippase activity" EXACT [] xref: EC:3.6.3.1 xref: MetaCyc:3.6.3.1-RXN xref: reactome:R-HSA-939763 "P-type ATPases type IV transport external-facing APLs to internal side of the plasma membrane" xref: reactome:R-HSA-947591 "P-type ATPases type IV transport internal-facing APLs to external side of the plasma membrane" xref: RHEA:14989 is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0043492 ! ATPase activity, coupled to movement of substances [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: goslim_chembl synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: reactome:R-HSA-174401 "AHCY:NAD+ tetramer hydrolyses AdoHcy" xref: RHEA:21708 is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0004014 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + H(+) = S-adenosylmethioninamine + CO(2)." [EC:4.1.1.50, RHEA:15981] synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: KEGG:R00178 xref: MetaCyc:SAMDECARB-RXN xref: reactome:R-HSA-351222 "S-Adenosyl methionine <=> Decarboxylated-Adenosyl methionine + CO2" xref: RHEA:15981 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004015 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 8-amino-7-oxononanoate + S-adenosyl-L-methionine(1+) = 7,8-diaminononanoate + S-adenosyl-4-methylthio-2-oxobutanoate." [EC:2.6.1.62, RHEA:16861] synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: KEGG:R03231 xref: MetaCyc:DAPASYN-RXN xref: RHEA:16861 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: reactome:R-HSA-164377 "Activated Adenylate cyclase catalyses cAMP synthesis" xref: reactome:R-HSA-170676 "Adenylate cyclase converts ATP into cyclic AMP" xref: reactome:R-HSA-381607 "Activated Adenylyl cyclase synthesizes cyclic AMP" xref: reactome:R-HSA-392129 "Adenylate cyclase converts ATP to 3',5'-cyclic AMP (cAMP) and pyrophosphate" xref: reactome:R-HSA-5211224 "Anthrax EF catalyzes the conversion of ATP to cAMP" xref: reactome:R-HSA-5610727 "GPR161 promotes cAMP production in a G alpha(s)-dependent manner" xref: RHEA:15389 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: reactome:R-HSA-110141 "(d)ADP + ADP <=> (d)AMP + ATP (AK1)" xref: reactome:R-HSA-110144 "ADP + ADP <=> AMP + ATP [AK2]" xref: reactome:R-HSA-110145 "AMP + ATP <=> ADP + ADP [AK2]" xref: reactome:R-HSA-74220 "(d)AMP + ATP <=> (d)ADP + ADP (AK1)" xref: RHEA:12973 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004018 name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG:R01083 xref: MetaCyc:AMPSYN-RXN xref: reactome:R-HSA-73800 "SAICAR => AICAR + Fumarate" xref: reactome:R-HSA-73828 "adenylosuccinate => adenosine 5'-monophosphate + fumarate" xref: RHEA:16853 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004019 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + GTP + IMP = N(6)-(1,2-dicarboxyethyl)-AMP + GDP + 3 H(+) + phosphate." [EC:6.3.4.4, RHEA:15753] synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: KEGG:R01135 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: reactome:R-HSA-111524 "IMP + L-Aspartate + GTP => Adenylosuccinate + GDP + Pi [ADSS]" xref: RHEA:15753 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004020 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: reactome:R-HSA-174389 "PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS" xref: RHEA:24152 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004021 name: L-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-alanine = L-glutamate + pyruvate." [EC:2.6.1.2, RHEA:19453] synonym: "alanine aminotransferase activity" BROAD [] synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: KEGG:R00258 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: reactome:R-HSA-507749 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT2]" xref: reactome:R-HSA-507775 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT2]" xref: reactome:R-HSA-70523 "alanine + alpha-ketoglutarate <=> pyruvate + glutamate [GPT]" xref: reactome:R-HSA-70524 "pyruvate + glutamate <=> alanine + alpha-ketoglutarate [GPT]" xref: RHEA:19453 is_a: GO:0047635 ! alanine-oxo-acid transaminase activity [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aldehyde dehydrogenase (NAD) activity" NARROW [] synonym: "aldo-keto reductase (NAD) activity" EXACT [] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: reactome:R-HSA-2162078 "abacavir + 2 NAD+ => abacavir 5'-carboxylate + 2 NADH + 2 H+" xref: UM-BBD_enzymeID:e0023 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004023 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004024 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] xref: reactome:R-HSA-71707 "ethanol + NAD+ => acetaldehyde + NADH + H+" is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004025 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004026 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-176494 "SULTs transfer (SO4)2- group to 27HCHOL" xref: reactome:R-HSA-176609 "cholesterol + PAPS => cholesterol sulfate + PAP" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004028 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] xref: reactome:R-HSA-71260 "ALDH9A1 tetramer dehydrogenates TEABL to form TEABT" xref: UM-BBD_enzymeID:e0432 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004029 name: aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: MetaCyc:ALDHDEHYDROG-RXN xref: reactome:R-HSA-380608 "5-hydroxyindole acetaldehyde to 5-hydroxyindole acetic acid" xref: reactome:R-HSA-389609 "ALDH3A2-2 oxidizes pristanal to pristanate" xref: reactome:R-HSA-5692261 "ALDH3A2-1 oxidises HD2NAL to PALM" xref: reactome:R-HSA-5696091 "ALDH1B1 tetramer oxidises CH3CHO to CH3COOH" xref: reactome:R-HSA-6808487 "ALDH1L2 dehydrogenates 10-formyl-THFPG to THFPG" xref: reactome:R-HSA-6808496 "ALDH1L1 dehydrogenates 10-formyl-THFPG to THFPG" xref: reactome:R-HSA-6813749 "ALDH1A1 oxidises GA to DGA" xref: reactome:R-HSA-71691 "acetaldehyde + NAD+ => acetate + NADH + H+ [cytosolic]" xref: reactome:R-HSA-71723 "acetaldehyde + NAD+ => acetate + NADH + H+ [mitochondrial]" xref: RHEA:16185 xref: UM-BBD_enzymeID:e0024 xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004030 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: reactome:R-HSA-5692283 "ALD3A1 oxidises 4HPCP to CXPA" xref: reactome:R-HSA-5696080 "ALDH3B1 oxidises HXAL to PALM" xref: reactome:R-HSA-6808464 "ALDH3B2 oxidises HXAL to PALM" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + hydrogen peroxide." [EC:1.2.3.1] synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN xref: reactome:R-HSA-3204311 "AOX1 oxidises PXL to PDXate" xref: RHEA:16829 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004032 name: alditol:NADP+ 1-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] synonym: "aldehyde reductase activity" EXACT [EC:1.1.1.21] synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: KEGG:R02820 "alditol:NADP+ 1-oxidoreductase" xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: reactome:R-HSA-196060 "Reduction of isocaproaldehyde to 4-methylpentan-1-ol" xref: reactome:R-HSA-5652172 "AKR1B1 reduces Glc to D-sorbitol" is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0004033 name: aldo-keto reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde or a ketone + NADPH + H+." [GOC:ai] synonym: "alcohol dehydrogenase (NADP+) activity" NARROW [] synonym: "aldo-keto reductase (NADP+) activity" EXACT [] synonym: "aldo-keto reductase activity" EXACT [] synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: EC:1.1.1 xref: reactome:R-HSA-192033 "4-cholesten-7alpha-ol-3-one is reduced to 5beta-cholestan-7alpha-ol-3-one" xref: reactome:R-HSA-192036 "5Beta-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha, 12alpha-triol" xref: reactome:R-HSA-192067 "4-cholesten-7alpha, 12alpha-diol-3-one is reduced to 5beta-cholesten-7alpha, 12alpha-diol-3-one" xref: reactome:R-HSA-192160 "5beta-cholestan-7alpha-ol-3-one is reduced to 5beta-cholestan-3alpha, 7alpha-diol" xref: reactome:R-HSA-193746 "4-cholesten-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-7alpha,24(S)-diol-3-one" xref: reactome:R-HSA-193755 "4-cholesten-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,24(S)-triol-3-one" xref: reactome:R-HSA-193758 "5beta-cholestan-7alpha,24(S)-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,24(S)-triol" xref: reactome:R-HSA-193781 "5Beta-cholestan-7alpha,12alpha,24(S)-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol" xref: reactome:R-HSA-193800 "5Beta-cholestan-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol" xref: reactome:R-HSA-193821 "4-cholesten-7alpha,12alpha,27-triol-3-one is reduced to 5beta-cholestan-7alpha,12alpha,27-triol-3-one" xref: reactome:R-HSA-193824 "4-cholesten-7alpha,27-diol-3-one is reduced to 5beta-cholestan-7alpha,27-diol-3-one" xref: reactome:R-HSA-193841 "5beta-cholestan-7alpha,27-diol-3-one is reduced to 5beta-cholestan-3alpha,7alpha,27-triol" xref: reactome:R-HSA-198845 "CYB5A:heme reduces SDA to VitC" xref: reactome:R-HSA-2855252 "AKRs reduce RBP2:atRAL to RBP2:atROL" xref: reactome:R-HSA-5423637 "AKR dimers reduce AFBDHO to AFBDOH" xref: reactome:R-HSA-5692232 "AKR1A1 oxidises BaPtDHD to BaP-7,8-dione" xref: reactome:R-HSA-9027531 "Dehydrogenase dehydrogenates 13-HDHA to 13-oxo-DHA" xref: reactome:R-HSA-9027562 "Dehydrogenase dehydrogenates 17-HDHA to 17-oxo-DHA" xref: reactome:R-HSA-9027598 "Dehydrogenase dehydrogenates 13(R)-HDPAn-3 to 13-oxo-DPAn-3" xref: reactome:R-HSA-9027600 "Dehydrogenase dehydrogenates 17-HDPAn-3 to 17-oxo-DPAn-3" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004034 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN xref: RHEA:10264 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004035 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: MetaCyc:ALKAPHOSPHA-RXN xref: reactome:R-HSA-8878787 "ALPI dimer hydrolyses phosphate monoesters" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004037 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H(2)O = (S)-ureidoglycolate + urea." [EC:3.5.3.4, RHEA:11016] synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: KEGG:R02422 xref: MetaCyc:ALLANTOICASE-RXN xref: RHEA:11016 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004038 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: MetaCyc:ALLANTOINASE-RXN xref: RHEA:17029 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004039 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 3 H(+) + urea-1-carboxylate = 2 CO(2) + 2 NH(4)(+)." [EC:3.5.1.54, RHEA:19029] synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: KEGG:R00005 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN xref: RHEA:19029 xref: UM-BBD_reactionID:r0848 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004040 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004042 name: acetyl-CoA:L-glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + acetyl-CoA = N-acetyl-L-glutamate + CoA + H(+)." [EC:2.3.1.1, RHEA:24292] synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: KEGG:R00259 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: reactome:R-HSA-70542 "glutamate + acetyl CoA => N-acetyl glutamate + CoA" xref: RHEA:24292 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: reactome:R-HSA-70941 "alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004044 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + L-glutamate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + L-glutamine + H(2)O." [EC:2.4.2.14, RHEA:14905] synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: KEGG:R01072 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: reactome:R-HSA-73815 "5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + H2O + L-glutamine <=> 5-phosphoribosylamine + L-glutamate +pyrophosphate" xref: RHEA:14905 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004045 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function alt_id: GO:0019850 alt_id: GO:0019851 def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004046 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: MetaCyc:AMINOACYLASE-RXN xref: reactome:R-HSA-5433074 "ACY:Zn2+ dimers hydrolyse mercapturic acids" xref: RHEA:15565 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004047 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: MetaCyc:GCVT-RXN xref: reactome:R-HSA-5693977 "AMT transfers NH2CH2 from GCSH:SAMDLL to THF" xref: RHEA:16945 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004048 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate + diphosphate = 5-phospho-alpha-D-ribose 1-diphosphate + anthranilate." [EC:2.4.2.18, RHEA:11768] synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: KEGG:R01073 xref: MetaCyc:PRTRANS-RXN xref: RHEA:11768 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004049 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: MetaCyc:ANTHRANSYN-RXN xref: RHEA:21732 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004050 name: obsolete apyrase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. synonym: "apyrase activity" EXACT [] is_obsolete: true consider: GO:0017110 consider: GO:0017111 [Term] id: GO:0004051 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN xref: reactome:R-HSA-265296 "Arachidonic acid is oxidised to 5S-HpETE by ALOX5" xref: reactome:R-HSA-266051 "5S-HpETE is dehydrated to LTA4 by ALOX5" xref: reactome:R-HSA-9018858 "ALOX5 oxidises 18(S)-HEPE to 5(S)-Hp-18(S)-HEPE" xref: reactome:R-HSA-9018859 "ALOX5 oxidises 5(S)-Hp-18(S)-HEPE to 5S,6S-epoxy-18(S)-HEPE" xref: reactome:R-HSA-9018863 "ALOX5 oxidises 18(R)-HEPE to 5(S)-Hp-18(R)-HEPE" xref: reactome:R-HSA-9018894 "ALOX5 oxidises 5(S)-Hp-18(R)-HEPE to 5S,6S-epoxy-18(R)-HEPE" xref: reactome:R-HSA-9020251 "ALOX5 oxidises 17(R)-HDHA to 7(S)-Hp-17(R)-HDHA" xref: reactome:R-HSA-9020255 "ALOX5 dehydrogenates 7(S)-Hp-17(S)-HDHA to 7S(8)-epoxy-17S-HDHA" xref: reactome:R-HSA-9020256 "ALOX5 dehydrogenates 7(S)-Hp-17R-HDHA to 7S(8)-epoxy-17R-HDHA" xref: reactome:R-HSA-9020259 "ALOX5 oxidises 17(R)-HDHA to 4(S)-Hp-17(R)-HDHA" xref: reactome:R-HSA-9020264 "ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA" xref: reactome:R-HSA-9020277 "ALOX5 dehydrogenates 4(S)-Hp-17(S)-HDHA to 4S(5)-epoxy-17(S)-HDHA" xref: reactome:R-HSA-9020278 "ALOX5 dehydrogenates 4(S)-Hp-17(R)-HDHA to 4S(5)-epoxy-17(R)-HDHA" xref: reactome:R-HSA-9020282 "ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA" xref: reactome:R-HSA-9024997 "ALOX5 oxidises 14(S)-Hp-DHA to 7(S),14(S)-diHp-DHA" xref: reactome:R-HSA-9025995 "ALOX5 dehydrogenates 7,17-diHp-DPAn-3 to 7,8-epoxy,17-HDPAn-3" xref: reactome:R-HSA-9025996 "ALOX5 oxidises 17(S)-Hp-DPAn-3 to 7,17-diHp-DPAn-3" xref: reactome:R-HSA-9025999 "ALOX5 dehydrogenates 17(S)-Hp-DPAn-3 to 16(S),17(S)-epoxy-DPAn-3" xref: reactome:R-HSA-9026005 "ALOX5 oxidises 14(S)-Hp-DPAn-3 to MaR3n-3 DPA" xref: reactome:R-HSA-9026405 "ALOX5 oxidises 13(R)-HDPAn-3 to RvT1-4" xref: reactome:R-HSA-9027624 "ALOX5 oxidises DHA to 7-HDHA" xref: reactome:R-HSA-9027628 "ALOX5 oxidises EPA to 5-HEPE" xref: reactome:R-HSA-9027633 "ALOX5 oxidises DPAn-3 to 7-HDPAn-3" xref: RHEA:24751 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004052 name: arachidonate 12-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O(2) = (5Z,8Z,10E,12S,14Z)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31, RHEA:10428] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: KEGG:R01596 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN xref: reactome:R-HSA-2161948 "Arachidonic acid is converted to 12-oxoETE by ALOX12" xref: reactome:R-HSA-2161950 "Arachidonic acid is oxidised to 12R-HpETE by ALOX12B" xref: reactome:R-HSA-2161964 "Arachidonic acid is oxidised to 12S-HpETE by ALOX12/15" xref: reactome:R-HSA-9024983 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DHA to 13(S),14(S)-epoxy-DHA" xref: reactome:R-HSA-9025957 "ALOX12:Fe2+ oxidises DPAn-6 to 14(S)-HDPAn-6" xref: reactome:R-HSA-9026006 "ALOX12:Fe2+ oxidises DPAn-3 to 14(S)-Hp-DPAn-3" xref: reactome:R-HSA-9026007 "ALOX12:Fe2+ dehydrogenates 14(S)-Hp-DPAn-3 to 13,14-epoxy-DPAn-3" xref: RHEA:10428 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004053 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: MetaCyc:ARGINASE-RXN xref: reactome:R-HSA-452036 "arginine + H2O => ornithine + urea [ARG2]" xref: reactome:R-HSA-70569 "arginine + H2O => ornithine + urea [ARG1]" xref: RHEA:20569 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004054 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + ATP = N(omega)-phospho-L-arginine + ADP + 2 H(+)." [EC:2.7.3.3, RHEA:22940] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: KEGG:R00554 xref: MetaCyc:ARGININE-KINASE-RXN xref: RHEA:22940 is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004055 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: MetaCyc:ARGSUCCINSYN-RXN xref: reactome:R-HSA-70577 "ASS1 tetramer:NMRAL1 dimer:NADPH transforms L-Asp and L-Cit to ARSUA" xref: RHEA:10932 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004056 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: MetaCyc:ARGSUCCINLYA-RXN xref: reactome:R-HSA-70573 "argininosuccinate <=> fumarate + arginine" xref: RHEA:24020 is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004057 name: arginyltransferase activity namespace: molecular_function alt_id: GO:0042172 def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0004058 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function alt_id: GO:0016400 def: "Catalysis of the reaction: L-amino acid + H+ = R-H + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" NARROW [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" NARROW [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" NARROW [EC:4.1.1.28] xref: EC:4.1.1.28 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN xref: reactome:R-HSA-209859 "Decarboxylation of 5-hydroxytryptophan forms serotonin" xref: reactome:R-HSA-209924 "Dopa is decarboxylated to dopamine" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004059 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-209792 "N-acetylation of serotonin" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004060 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-174963 "NAT1 acetylation" xref: reactome:R-HSA-174967 "NAT2 acetylation" xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004061 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: reactome:R-HSA-71189 "AFMID hydrolyses NFK to L-KYN" xref: RHEA:13009 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: goslim_chembl synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-158468 "SULT1A1 dimer sulfonates PARA to PARA-SO4" xref: reactome:R-HSA-158849 "Phenol can form a sulfate conjugate" xref: reactome:R-HSA-158860 "SULT1A1 dimer sulfonates NHABP" xref: reactome:R-HSA-159358 "SULT1A3,4 dimers sulfate DA to DAOS" xref: reactome:R-HSA-176474 "3,3'-diiodothyronine + PAPS => 3,3'-diiodothyronine 4-sulfate + PAP" xref: reactome:R-HSA-176585 "3,5,3'-triiodothyronine + PAPS => 3,5,3'-triiodothyronine 4-sulfate + PAP" xref: reactome:R-HSA-176646 "p-nitrophenol + PAPS => p-nitrophenol sulfate + PAP" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004063 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004064 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN xref: UM-BBD_reactionID:r0757 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004065 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate." [EC:3.1.6.1] synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004066 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: MetaCyc:ASNSYNB-RXN xref: reactome:R-HSA-70599 "aspartate + glutamine + ATP <=> asparagine + glutamate + AMP + pyrophosphate [ASNS]" xref: RHEA:24877 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004067 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: MetaCyc:ASPARAGHYD-RXN xref: reactome:R-HSA-6797627 "ASPG hydrolyses L-Asn to L-Asp" xref: RHEA:21016 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004068 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 xref: RHEA:19497 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004069 name: L-aspartate:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" BROAD [] synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" RELATED [EC:2.6.1.1] xref: EC:2.6.1.1 xref: KEGG:R00355 xref: MetaCyc:ASPAMINOTRANS-RXN xref: reactome:R-HSA-70581 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT1]" xref: reactome:R-HSA-70592 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT1]" xref: reactome:R-HSA-70596 "aspartate + alpha-ketoglutarate <=> oxaloacetate + glutamate [GOT2]" xref: reactome:R-HSA-70613 "oxaloacetate + glutamate <=> aspartate + alpha-ketoglutarate [GOT2]" xref: RHEA:21824 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004070 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + carbamoyl phosphate = N-carbamoyl-L-aspartate + H(+) + phosphate." [EC:2.1.3.2, RHEA:20013] synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: KEGG:R01397 xref: MetaCyc:ASPCARBTRANS-RXN xref: reactome:R-HSA-73573 "carbamoyl phosphate + L-aspartate <=> N-carbamoyl L-aspartate + orthophosphate" xref: RHEA:20013 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004071 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: MetaCyc:ASNSYNA-RXN xref: RHEA:11372 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004072 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H(+)." [EC:2.7.2.4, RHEA:23776] synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: KEGG:R00480 xref: MetaCyc:ASPARTATEKIN-RXN xref: RHEA:23776 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004073 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate 4-semialdehyde + NADP(+) + phosphate = 4-phospho-L-aspartate + H(+) + NADPH." [EC:1.2.1.11, RHEA:24284] synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: KEGG:R02291 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24284 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004074 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN xref: reactome:R-HSA-189384 "Biliverdin is reduced to bilirubin" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004075 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004076 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + dethiobiotin + S(2-) = 2 5'-deoxyadenosine + 2 L-methionine + biotin + H(+)." [EC:2.8.1.6, RHEA:22060] synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: KEGG:R01078 xref: MetaCyc:2.8.1.6-RXN xref: RHEA:22060 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004077 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004078 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004079 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004080 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN xref: reactome:R-HSA-5696197 "NUDT2 hydrolyses GP4G to GTP, GMP" xref: RHEA:22484 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0004082 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN xref: reactome:R-HSA-6798335 "BPGM dimer isomerises 1,3BPG to 2,3BPG" xref: RHEA:17765 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004083 name: bisphosphoglycerate 2-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bisphospho-D-glycerate + H(2)O = 3-phospho-D-glycerate + phosphate." [EC:3.1.3.13, RHEA:21904] synonym: "2,3-bisphospho-D-glycerate 2-phosphohydrolase activity" BROAD [EC:3.1.3.13] xref: EC:3.1.3.13 xref: KEGG:R01516 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN xref: RHEA:21904 is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0004084 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid." [EC:2.6.1.42, GOC:mah] synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: reactome:R-HSA-508179 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT2]" xref: reactome:R-HSA-508189 "a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate <=> leu, ile, or val + alpha-ketoglutarate [BCAT1]" xref: reactome:R-HSA-70723 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT1]" xref: reactome:R-HSA-70724 "leu, ile, or val + alpha-ketoglutarate <=> a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004085 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + electron-transfer flavoprotein = 2-butenoyl-CoA + reduced electron-transfer flavoprotein." [EC:1.3.8.1] synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.8.1] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "ethylene reductase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.8.1] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.8.1] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.8.1] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.8.1] xref: EC:1.3.8.1 xref: KEGG:R01178 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0013 is_a: GO:0052890 ! oxidoreductase activity, acting on the CH-CH group of donors, with a flavin as acceptor [Term] id: GO:0004086 name: obsolete carbamoyl-phosphate synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] comment: This term was made obsolete because it is a grouping term based on name, rather than on function. synonym: "carbamoyl phosphate synthase activity" EXACT [] synonym: "carbamoyl-phosphate synthase activity" EXACT [] is_obsolete: true consider: GO:0004087 consider: GO:0004088 [Term] id: GO:0004087 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + CO(2) + H(2)O + NH(4)(+) = 2 ADP + carbamoyl phosphate + 5 H(+) + phosphate." [EC:6.3.4.16, RHEA:10624] synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: KEGG:R00149 xref: MetaCyc:6.3.4.16-RXN xref: reactome:R-HSA-70555 "2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial]" xref: RHEA:10624 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004088 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: MetaCyc:CARBPSYN-RXN xref: reactome:R-HSA-73577 "L-glutamine + 2 ATP + HCO3- + H2O => carbamoyl phosphate + L-glutamate + 2 ADP + orthophosphate" xref: RHEA:24654 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004089 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: MetaCyc:CARBODEHYDRAT-RXN xref: reactome:R-HSA-1237045 "Carbonic Anhydrase VI hydrates carbon dioxide to bicarbonate and a proton" xref: reactome:R-HSA-1237047 "Carbonic anhydrase IV hydrates carbon dioxide to bicarbonate and a proton" xref: reactome:R-HSA-1237059 "Carbonic anhydrase IV dehydrates bicarbonate to water and carbon dioxide" xref: reactome:R-HSA-1237081 "Carbonic anhydrase VI dehydrates bicarbonate to water and carbon dioxide" xref: reactome:R-HSA-1475017 "Carbonic anhydrase dehydrates bicarbonate (plasma membrane)" xref: reactome:R-HSA-1475022 "Carbonic anhydrase dehydrates bicarbonate (cytosol)" xref: reactome:R-HSA-1475025 "Carbonic anhydrase hydrates carbon dioxide (plasma membrane)" xref: reactome:R-HSA-1475026 "Carbonic anhydrase hydrates carbon dioxide (cytosol)" xref: reactome:R-HSA-1475028 "Carbonic anhydrase dehydrates bicarbonate (mitochondria)" xref: reactome:R-HSA-1475032 "Carbonic anhydrase hydrates carbon dioxide (mitochondria)" xref: reactome:R-HSA-1475435 "Carbonic anhydrase I/II hydrates carbon dioxide" xref: reactome:R-HSA-1475436 "Carbonic anhydrase I/II dehydrates bicarbonate" xref: RHEA:10748 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004090 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN xref: reactome:R-HSA-8937419 "CBR3 reduces DOX to DOXOL" xref: RHEA:19257 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004092 name: carnitine O-acetyltransferase activity namespace: molecular_function alt_id: GO:0004093 alt_id: GO:0004094 def: "Catalysis of the reaction: acetyl-CoA + carnitine = (R)-O-acetylcarnitine + CoA." [EC:2.3.1.7, RHEA:21136] synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: KEGG:R02396 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-390284 "propionyl-CoA + carnitine => propionylcarnitine + CoASH" xref: reactome:R-HSA-390291 "acetyl-CoA + carnitine => acetylcarnitine + CoASH" xref: RHEA:21136 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004095 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN xref: reactome:R-HSA-200406 "CPT1A,B transfers PALM to CAR" xref: reactome:R-HSA-200410 "palmitoylcarnitine + CoASH => palmitoyl-CoA + carnitine" xref: RHEA:12661 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 hydrogen peroxide = O2 + 2 H2O." [EC:1.11.1.6] synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: reactome:R-HSA-1222704 "KatG reduces H2O2" xref: reactome:R-HSA-76031 "2 H2O2 => O2 + 2 H2O" xref: RHEA:20309 xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004097 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] comment: GO:0004097 describes oxidation of catechols (i.e., o-diphenols) to the corresponding o-quinones. For monooxygenation of monophenols, consider instead the term 'monophenol monooxygenase activity ; GO:0004503'. synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: MetaCyc:CATECHOL-OXIDASE-RXN xref: RHEA:21632 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0004098 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + sulfate." [EC:3.1.6.8] synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN xref: reactome:R-HSA-1606807 "Arylsulfatase A hydrolyses sulfate from sulfatide to form cerebroside" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004099 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: MetaCyc:CHITIN-DEACETYLASE-RXN xref: RHEA:10464 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0004100 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n) = UDP + [->4)-N-acetyl-beta-D-glucosaminyl-(1-](n+1)." [EC:2.4.1.16] synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004102 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = acetylcholine + CoA." [EC:2.3.1.6, RHEA:18821] synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: KEGG:R01023 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-264622 "Cho is acetylated to AcCho by CHAT" xref: RHEA:18821 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + choline phosphate + 2 H(+)." [EC:2.7.1.32, RHEA:12837] synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: KEGG:R01021 xref: MetaCyc:CHOLINE-KINASE-RXN xref: reactome:R-HSA-1483004 "Cho is phosphorylated to PCho by CHK dimer" xref: RHEA:12837 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: goslim_chembl synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: RHEA:21964 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004105 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: MetaCyc:2.7.7.15-RXN xref: reactome:R-HSA-1483081 "PCho and CTP are condensed to CDP-Cho by PCYT1 dimer" xref: RHEA:18997 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004106 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5, RHEA:13897] synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: KEGG:R01715 xref: MetaCyc:CHORISMATEMUT-RXN xref: RHEA:13897 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004107 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5, RHEA:21020] synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: KEGG:R01714 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN xref: RHEA:21020 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: reactome:R-HSA-70975 "Acetyl-CoA + H2O + Oxaloacetate => Citrate + CoA" is_a: GO:0036440 ! citrate synthase activity [Term] id: GO:0004109 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen III + 2 H(+) + O(2) = 2 CO(2) + 2 H(2)O + protoporphyrinogen IX." [EC:1.3.3.3, RHEA:18257] synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: KEGG:R03220 xref: MetaCyc:RXN0-1461 xref: reactome:R-HSA-189421 "CPO transforms COPRO3 to PPGEN9" xref: RHEA:18257 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004110 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21, RHEA:17861] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: KEGG:R04165 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN xref: RHEA:17861 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004111 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = N-phosphocreatine + ADP + 2 H(+)." [EC:2.7.3.2, RHEA:17157] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: KEGG:R01881 xref: MetaCyc:CREATINE-KINASE-RXN xref: reactome:R-HSA-200318 "creatine + ATP => phosphocreatine + ADP [CKB,CKM]" xref: reactome:R-HSA-200326 "creatine + ATP => phosphocreatine + ADP [CK octamer]" xref: RHEA:17157 is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004112 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004113 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004114 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: MetaCyc:3.1.4.17-RXN xref: reactome:R-HSA-162425 "p-S295-PDE3B hydrolyses cAMP to AMP" xref: RHEA:14653 is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004115 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4 xref: MetaCyc:RXN0-5038 xref: reactome:R-HSA-111962 "cAMP hydrolysis by PDE 4" xref: reactome:R-HSA-418553 "cAMP degradation by Phosphodiesterases" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004117 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4 xref: reactome:R-HSA-111955 "cAMP hydrolysis by Cam-PDE 1" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004118 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004119 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside cyclic phosphate + H2O = nucleoside phosphate. This reaction is the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] xref: EC:3.1.4 is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004121 name: cystathionine beta-lyase activity namespace: molecular_function alt_id: GO:0008799 def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN xref: RHEA:13965 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004122 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN xref: reactome:R-HSA-1614524 "Cystathionine is formed from homocysteine and serine" xref: RHEA:10112 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004123 name: cystathionine gamma-lyase activity namespace: molecular_function alt_id: GO:0016225 def: "Catalysis of the reaction: L-cystathionine + H2O = 2-oxobutanoate + L-cysteine + NH4+." [RHEA:24918] synonym: "gamma-cystathionase activity" BROAD [EC:4.4.1.1] synonym: "homoserine deaminase activity" RELATED [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" RELATED [EC:4.4.1.1] synonym: "homoserine dehydratase activity" RELATED [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" BROAD [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: KEGG:R01001 xref: MetaCyc:CYSTAGLY-RXN xref: reactome:R-HSA-1614583 "Cleavage of cystathionine into cysteine" xref: RHEA:24918 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + hydrogen sulfide = L-cysteine + acetate." [EC:2.5.1.47] comment: Note that this function was formerly 4.2.99.8. synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN xref: RHEA:14829 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004125 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN is_a: GO:0016785 ! transferase activity, transferring selenium-containing groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004126 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: MetaCyc:CYTIDEAM2-RXN xref: reactome:R-HSA-73608 "(deoxy)cytidine + H2O => (deoxy)uridine + NH4+ (CDA)" xref: reactome:R-HSA-83677 "C4 deamination of cytidine" xref: RHEA:16069 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004127 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: MetaCyc:CMPKI-RXN is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004128 name: cytochrome-b5 reductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + 2 ferricytochrome b(5) = NAD(P)+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: reactome:R-HSA-198824 "CYB5R3:FAD reduces CYB5A:ferriheme to CYB5A:heme" xref: reactome:R-HSA-6806831 "CYB5Rs reduce MetHb to HbA" is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: The reduction of O2 to water is accompanied by the extrusion of four protons from the intramitochondrial compartment. synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome c oxidase activity" EXACT [GOC:tb] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: reactome:R-HSA-163214 "Electron transfer from reduced cytochrome c to molecular oxygen" is_a: GO:0009055 ! electron transfer activity is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor [Term] id: GO:0004130 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + hydrogen peroxide = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004131 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: MetaCyc:CYTDEAM-RXN xref: RHEA:20605 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004132 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: reactome:R-HSA-73596 "dCMP + H2O => dUMP + NH4+" xref: RHEA:22924 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004133 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732] subset: goslim_pir is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004134 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan." [EC:2.4.1.25] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: MetaCyc:AMYLOMALT-RXN xref: MetaCyc:RXN-1828 xref: MetaCyc:RXN-9023 xref: reactome:R-HSA-71552 "limit dextrin-glycogenin => ((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl) glycogenin" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004135 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the (1->6) glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732] synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: MetaCyc:3.2.1.33-RXN xref: reactome:R-HSA-71593 "((1,6)-alpha-glucosyl)poly((1,4)-alpha-glucosyl)glycogenin => poly{(1,4)-alpha-glucosyl} glycogenin + alpha-D-glucose" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004136 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyadenosine + ATP = ADP + dAMP + 2 H(+)." [EC:2.7.1.76, RHEA:23452] synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: KEGG:R02089 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN xref: RHEA:23452 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004137 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN xref: RHEA:20061 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004138 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyguanosine + ATP = ADP + dGMP + 2 H(+)." [EC:2.7.1.113, RHEA:19201] synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: KEGG:R01967 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN xref: RHEA:19201 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004139 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4, RHEA:12821] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: KEGG:R01066 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN xref: reactome:R-HSA-6787321 "DERA cleaves dR5P to GA3P and CH3CHO" xref: RHEA:12821 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004140 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-dephospho-CoA + ATP = ADP + CoA + 2 H(+)." [EC:2.7.1.24, RHEA:18245] synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: KEGG:R00130 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN xref: reactome:R-HSA-196773 "COASY phosphorylates DP-CoA" xref: RHEA:18245 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004141 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-diaminononanoate + ATP + CO(2) = ADP + dethiobiotin + 4 H(+) + phosphate." [EC:6.3.3.3, RHEA:15805] synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: KEGG:R03182 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN xref: RHEA:15805 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004142 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: MetaCyc:RXN-5781 xref: reactome:R-HSA-1482961 "CDP-Cho and DAG are converted to PC by CEPT1 at the ER membrane" xref: reactome:R-HSA-1482973 "CDP-Cho and DAG are converted to PC by CHPT1 at the Golgi membrane" xref: RHEA:10308 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004143 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate." [EC:2.7.1.107, GOC:elh] synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "CTP:diacylglycerol kinase activity" NARROW [] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: MetaCyc:DIACYLGLYKIN-RXN xref: reactome:R-HSA-426240 "DAG kinase produces phosphatidic acid from DAG" xref: RHEA:10272 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: reactome:R-HSA-1482889 "DAG is acylated to TAG by DGAT1/2" xref: reactome:R-HSA-549192 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT2]" xref: reactome:R-HSA-75900 "1,2-diacyl-glycerol + acyl-CoA => triacylglycerol + CoASH [DGAT1]" xref: reactome:R-HSA-8848580 "DGAT2L6,L7P transfer acyl group from acyl-CoA to DAG, forming TAG" xref: RHEA:10868 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0004145 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: MetaCyc:DIAMACTRANS-RXN xref: reactome:R-HSA-351207 "Spermine => N-acetylated spermine" xref: reactome:R-HSA-351208 "Spermidine => N-acetylated spermidine" xref: RHEA:25181 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004146 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN xref: reactome:R-HSA-1497794 "Salvage - BH2 is reduced to BH4 by DHFR" xref: RHEA:15009 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004147 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] xref: EC:2.3.1 is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004148 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: MetaCyc:DIHYDLIPOXN-RXN xref: reactome:R-HSA-1222412 "Lpd reactivates dlaT" xref: reactome:R-HSA-5694018 "DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate" xref: RHEA:15045 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004149 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 is_a: GO:0016751 ! S-succinyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004150 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: MetaCyc:H2NEOPTERINALDOL-RXN xref: RHEA:10540 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004151 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H(2)O = N-carbamoyl-L-aspartate + H(+)." [EC:3.5.2.3, RHEA:24296] synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: KEGG:R01993 xref: MetaCyc:DIHYDROOROT-RXN xref: reactome:R-HSA-73571 "N-carbamoyl L-aspartate + H+ <=> (S)-dihydroorotate + H2O" xref: RHEA:24296 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004152 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + A = AH(2) + orotate." [EC:1.3.5.2, RHEA:18073] synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.5.2] synonym: "(S)-dihydroorotate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.3.5.2] synonym: "DHOdehase activity" EXACT [EC:1.3.5.2] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.5.2] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.5.2] xref: EC:1.3.5.2 xref: KEGG:R01868 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: reactome:R-HSA-73569 "(S)-dihydroorotate + ubiquinone => orotate + ubiquinol" xref: RHEA:18073 is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0004153 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H2O = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004154 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + hydrogen peroxide." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004155 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: MetaCyc:1.5.1.34-RXN xref: reactome:R-HSA-71130 "q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004156 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: MetaCyc:H2PTEROATESYNTH-RXN xref: RHEA:19949 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004157 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: reactome:R-HSA-73589 "5,6-dihydrouracil + H2O => beta-ureidopropionate" xref: reactome:R-HSA-73618 "5,6-dihydrothymine + H2O => beta-ureidoisobutyrate" xref: RHEA:16121 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004158 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O(2) = H(2)O(2) + orotate." [EC:1.3.3.1, RHEA:15441] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: RHEA:15441 is_a: GO:0004152 ! dihydroorotate dehydrogenase activity is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004159 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN xref: RHEA:20189 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004160 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN xref: RHEA:20936 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004161 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl diphosphate synthase" EXACT [] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: MetaCyc:GPPSYN-RXN xref: reactome:R-HSA-191322 "Addition of isopentenyl pyrophosphate to DMAPP" xref: RHEA:22408 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004162 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0004163 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-diphosphomevalonate + ATP = ADP + CO(2) + H(+) + isopentenyl diphosphate + phosphate." [EC:4.1.1.33, RHEA:23732] synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: KEGG:R01121 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: reactome:R-HSA-191414 "MVD decarboxylates MVA5PP to IPPP" xref: RHEA:23732 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004164 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: MetaCyc:RXN-11370 xref: reactome:R-HSA-5358484 "DPH5 transfers four methyl groups from AdoMet to aminocarboxypropyl EEF2" xref: RHEA:20145 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004165 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function alt_id: GO:0008461 def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: reactome:R-HSA-109338 "Isomerization of cis,cis-3,6-Dodecadienoyl-CoA to form trans,cis-Lauro-2,6-dienoyl-CoA" xref: reactome:R-HSA-6809808 "ECI2 isomerizes 3Z-enoyl-CoA to 2E-enoyl-CoA" xref: RHEA:23716 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004166 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0004101 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: MetaCyc:2.4.1.153-RXN xref: RHEA:14693 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004167 name: dopachrome isomerase activity namespace: molecular_function alt_id: GO:0048059 def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12, RHEA:13041] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: KEGG:R03673 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN xref: RHEA:13041 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004168 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: MetaCyc:DOLICHOL-KINASE-RXN xref: reactome:R-HSA-446195 "DOLK phosphorylates DCHOL to DOLP" xref: RHEA:13133 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004169 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109, GOC:pr] comment: Note that this activity has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: MetaCyc:2.4.1.109-RXN xref: reactome:R-HSA-5615637 "POMT1:POMT2 transfers Man from Dol-P-Man to DAG1(30-653)" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: goslim_chembl synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: KEGG:R02100 xref: MetaCyc:DUTP-PYROP-RXN xref: reactome:R-HSA-73666 "dUTP + H2O => dUMP + pyrophosphate" xref: RHEA:10248 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0004171 name: obsolete deoxyhypusine synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] comment: This term was made obsolete because it represents a multistep reaction. synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] synonym: "deoxyhypusine synthase activity" EXACT [] is_obsolete: true consider: GO:0008612 consider: GO:0034038 [Term] id: GO:0004172 name: obsolete ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. synonym: "ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity" EXACT [] is_obsolete: true consider: GO:0050488 [Term] id: GO:0004173 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: Ecdysone + palmitoyl-CoA = CoA + ecdysone palmitate." [EC:2.3.1.139, RHEA:15217] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: KEGG:R02375 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN xref: RHEA:15217 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004174 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: reactome:R-HSA-169270 "ETFDH oxidises ETF (reduced) to ETF, reduces CoQ to QH2" is_a: GO:0009055 ! electron transfer activity is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "elastase activity" RELATED [GOC:krc] synonym: "endoprotease activity" NARROW [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" NARROW [] xref: MetaCyc:RXN0-5195 xref: reactome:R-HSA-1168640 "Ubiquitinated IkB is degraded" xref: reactome:R-HSA-1234159 "Proteasome proteolyzes ub-HIF-alpha" xref: reactome:R-HSA-1236935 "Proteasomal cleavage of substrate" xref: reactome:R-HSA-1236970 "Proteasomal clevage of exogenous antigen" xref: reactome:R-HSA-1251997 "Cleavage of ERBB4m80 by gamma-scretase complex" xref: reactome:R-HSA-1433374 "Processing of SCF isoform 1" xref: reactome:R-HSA-1504193 "Ubiquitinated DVL is degraded by the proteasome" xref: reactome:R-HSA-174058 "Degradation of multiubiquitinated Cdh1" xref: reactome:R-HSA-174105 "Degradation of multiubiquitinated cell cycle proteins" xref: reactome:R-HSA-174202 "Degradation of multiubiquitinated Securin" xref: reactome:R-HSA-174203 "SCF-mediated degradation of Emi1" xref: reactome:R-HSA-174255 "Degradation multiubiquitinated Cyclin A" xref: reactome:R-HSA-180573 "Degradation of ubiquitinated CD4" xref: reactome:R-HSA-180603 "Proteosome-mediated degradation of APOBEC3G" xref: reactome:R-HSA-187574 "Degradation of ubiquitinated p27/p21 by the 26S proteasome" xref: reactome:R-HSA-188191 "APC/C:Cdh1-mediated degradation of Skp2" xref: reactome:R-HSA-193682 "gamma-secretase cleaves the p75NTR transmembrane domain" xref: reactome:R-HSA-209061 "Ubiquitinated and phosphorylated IKBA binds to and is degraded by the proteasome complex" xref: reactome:R-HSA-211715 "Proteasome mediated degradation of PAK-2p34" xref: reactome:R-HSA-2130282 "Degradation of ubiquitinated beta catenin by the proteasome" xref: reactome:R-HSA-2213200 "Release of endostatin-like peptides" xref: reactome:R-HSA-264458 "Proteasome mediated degradation of COP1" xref: reactome:R-HSA-353125 "26S proteosome degrades ODC holoenzyme complex" xref: reactome:R-HSA-3640874 "Ub-RibC-AXIN is degraded by the proteasome" xref: reactome:R-HSA-3928656 "gamma-secretase cleaves EPHB2" xref: reactome:R-HSA-450466 "AUF1:mRNA complex is destroyed" xref: reactome:R-HSA-4608855 "PRICKLE1 is degraded by the proteasome" xref: reactome:R-HSA-4641256 "Ubiquitinated AXIN is degraded by the proteasome" xref: reactome:R-HSA-4641260 "Ubiquitinated DVL1 is degraded by the proteasome" xref: reactome:R-HSA-5358340 "Autoproteolytic cleavage of Hh precursors" xref: reactome:R-HSA-5358460 "HPE SHH variants don't undergo autoproteolytic cleavage" xref: reactome:R-HSA-5362448 "Hh C-terminal fragments are degraded by the proteasome" xref: reactome:R-HSA-5387392 "processing defective Hh variants are degraded by the proteasome" xref: reactome:R-HSA-5607724 "26S proteasome processes K48PolyUb-K21,22-p-S32,36-IkBA:NF-kB complex to form NF-kB complex" xref: reactome:R-HSA-5607731 "26S proteasome processes p-7S-p100:RELB to form p52:RELB" xref: reactome:R-HSA-5610754 "GLI3 is partially degraded by the proteasome to yield the GLI3 repressor" xref: reactome:R-HSA-5610757 "GLI2 is degraded by the proteasome" xref: reactome:R-HSA-5610758 "GLI1 is degraded by the proteasome after ubiquitination by beta-TrCP" xref: reactome:R-HSA-5610760 "GLI1 is degraded by the proteasome after ubiquitination by ITCH" xref: reactome:R-HSA-5635854 "GLI2,3 are degraded by the proteasome" xref: reactome:R-HSA-5635868 "ub-GLI is degraded by the proteasome" xref: reactome:R-HSA-5658430 "NF1 is degraded by the proteasome" xref: reactome:R-HSA-5668481 "Protesomal degradation of K48polyUb-TRAF3" xref: reactome:R-HSA-5668520 "26Sproteasome degrades K48polyUb-NIK" xref: reactome:R-HSA-5687112 "MAPK6 is degraded by the 26S proteasome" xref: reactome:R-HSA-5693081 "FURIN cleaves 7K-BACE1 to 7K-BACE1(46-501)" xref: reactome:R-HSA-6784628 "PCSK6,FURIN mediate dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: reactome:R-HSA-6784676 "PCSK5 mediates dissociation of 2 x LPL from GPIHBP1:HSPG:LPL dimer" xref: reactome:R-HSA-68825 "Ubiquitinated geminin is degraded by the proteasome" xref: reactome:R-HSA-68948 "Ubiquitinated Orc1 is degraded by the proteasome" xref: reactome:R-HSA-69016 "Ubiquitinated Cdc6 is degraded by the proteasome" xref: reactome:R-HSA-69600 "Proteolytic degradation of ubiquitinated-Cdc25A" xref: reactome:R-HSA-74730 "Insulin degradation" xref: reactome:R-HSA-75825 "Proteasome mediated degradation of Cyclin D1" xref: reactome:R-HSA-8849797 "Membrane proteases cleave Profilaggrin producing Filaggrin" xref: reactome:R-HSA-8850992 "Proteasome degrades polyubiquitinated PTEN" xref: reactome:R-HSA-8852354 "GTSE1 facilitates proteasome-mediated degradation of TP53" xref: reactome:R-HSA-8854044 "Proteasome degrades AURKA ubiquitinated by SCF-FBXL7" xref: reactome:R-HSA-8854071 "Proteasome-mediated degradation of PolyUb-FBXL7" xref: reactome:R-HSA-8866553 "misfolded CFTR is degraded by the 26S proteasome" xref: reactome:R-HSA-8866858 "CFTR F508del is degraded by the 26S proteasome" xref: reactome:R-HSA-8934819 "Cytoplasmic proteases cleave Profilaggrin producing Filaggrin" xref: reactome:R-HSA-8939801 "26S proteasome degrades PolyUb-RUNX2" xref: reactome:R-HSA-8952408 "Polyubiquitinated RUNX3 is degraded by the proteasome" xref: reactome:R-HSA-8957265 "26S proteasome degrades TP73 polyubiquitinated by ITCH" xref: reactome:R-HSA-9008110 "Proteasome degrades polyubiquitinated RUNX2" xref: reactome:R-HSA-9008475 "Proteasome degrades polyubiquitinated RUNX2" xref: reactome:R-HSA-9009362 "Proteasome degrades PolyUb-RUNX2" xref: reactome:R-HSA-9010096 "Gamma-secretase cleaves APP(672-770) to APP(672-711) and APP(672-713)" xref: reactome:R-HSA-9011313 "Proteasome degrades ubiquitinated ROBO3.1" xref: reactome:R-HSA-9604642 "Proteasome degrades ubiquitinated NICD4" xref: reactome:R-HSA-983150 "Proteasomal cleavage of substrate" xref: reactome:R-HSA-983158 "Trimming of peptides in ER" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the hydrolysis of peptide bonds." [GOC:mah] synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732] xref: EC:3.4.11 xref: MetaCyc:RXN0-5052 xref: reactome:R-HSA-1236954 "Trimming of peptides by IRAP in endocytic vesicles" xref: reactome:R-HSA-2534096 "METAP1/2 demethylates GNAT1" xref: reactome:R-HSA-8851929 "AOPEP:Zn2+ hydrolyses AGT(35-41) to AGT(36-41)" xref: reactome:R-HSA-983162 "Trimming of N-ter extended precursor fragments by cytosolic aminopeptidases" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004178 name: obsolete leucyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl aminopeptidase activity" EXACT [] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: MetaCyc:3.4.11.1-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004179 name: obsolete membrane alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] comment: This term was made obsolete because it represents a gene product. synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane alanyl aminopeptidase activity" EXACT [] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: MetaCyc:3.4.11.2-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732] xref: reactome:R-HSA-1247910 "CNDP2:2Mn2+ dimer hydrolyses CysGly" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004181 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0198506732] xref: EC:3.4.17 xref: reactome:R-HSA-2022378 "ACE2 hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-9)" xref: reactome:R-HSA-2022379 "ACE2 hydrolyzes Angiotensin-(1-8) to Angiotensin-(1-7)" xref: reactome:R-HSA-2028294 "Mast Cell Carboxypeptidase hydrolyzes Angiotensin-(1-10) to Yield Angiotensin-(1-9)" xref: reactome:R-HSA-8852809 "CPN, CPB2 cleave C3a, C5a" xref: reactome:R-HSA-8866105 "CCPs deglutamylate tubulin" xref: reactome:R-HSA-8955712 "TTCP hydrolyzes the terminal L-Tyr residue from alpha-tubulin" xref: reactome:R-HSA-9023159 "Carboxypeptidase E cleaves C-peptide (Insulin(57-89)) to yield C-peptide (Insulin(57-87))" xref: reactome:R-HSA-9023163 "Carboxypeptidase E cleaves Insulin(25-56) to yield Insulin(25-54)" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0004182 name: obsolete carboxypeptidase A activity namespace: molecular_function alt_id: GO:0008731 def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase A activity" EXACT [] synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004183 name: obsolete carboxypeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase E activity" EXACT [] synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004184 name: obsolete lysine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] comment: This term was made obsolete because it represents a gene product. synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004185 name: serine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 xref: reactome:R-HSA-158251 "prekallikrein:kininogen:C1q binding protein tetramer -> kallikrein:kininogen:C1q binding protein tetramer" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0004186 name: obsolete carboxypeptidase C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase C activity" EXACT [] synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] synonym: "deamidase" RELATED [EC:3.4.16.5] synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] xref: EC:3.4.16.5 xref: MetaCyc:3.4.16.5-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004187 name: obsolete carboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D activity" EXACT [] synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] synonym: "CPDW-II" RELATED [EC:3.4.16.6] synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] xref: EC:3.4.16.6 xref: MetaCyc:3.4.16.6-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004188 name: obsolete serine-type Pro-X carboxypeptidase activity namespace: molecular_function alt_id: GO:0008323 def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "PCP" RELATED [EC:3.4.16.2] synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "serine-type Pro-X carboxypeptidase activity" EXACT [] xref: EC:3.4.16.2 xref: MetaCyc:3.4.16.2-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004189 name: obsolete tubulinyl-Tyr carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] comment: This term was made obsolete because it represents a gene product. synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] synonym: "TTCPase activity" EXACT [EC:3.4.17.17] synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulinyl-Tyr carboxypeptidase activity" EXACT [] synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] xref: EC:3.4.17.17 xref: MetaCyc:3.4.17.17-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004190 name: aspartic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732] synonym: "aspartate protease activity" NARROW [GOC:mah, GOC:vw] synonym: "aspartic endopeptidase activity" EXACT [] synonym: "aspartic protease activity" NARROW [] synonym: "aspartyl protease activity" NARROW [] synonym: "carboxyl protease activity" NARROW [] xref: EC:3.4.23 xref: reactome:R-HSA-157353 "NEXT1 is cleaved to produce NICD1" xref: reactome:R-HSA-157640 "NEXT2 is cleaved to produce NICD2" xref: reactome:R-HSA-2022403 "Renin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: reactome:R-HSA-2022412 "Renin hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: reactome:R-HSA-2065357 "Prorenin:Prorenin Receptor hydrolyzes Angiotensinogen to Angiotensin-(1-10)" xref: reactome:R-HSA-2220988 "NEXT1 PEST domain mutants are cleaved to produce NICD1 PEST domain mutants" xref: reactome:R-HSA-373705 "Caspase cleavage of DCC" xref: reactome:R-HSA-9013361 "NEXT3 is cleaved to produce NICD3" xref: reactome:R-HSA-9017817 "Gamma-secretase cleaves YBX1:NOTCH3" xref: reactome:R-HSA-9604294 "Gamma-secretase cleaves NOTCH4" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070001 ! aspartic-type peptidase activity [Term] id: GO:0004191 name: obsolete barrierpepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] comment: This term was made obsolete because it represents a gene product. synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "barrierpepsin activity" EXACT [] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] xref: EC:3.4.23.35 xref: MetaCyc:3.4.23.35-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004192 name: obsolete cathepsin D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D activity" EXACT [] xref: EC:3.4.23.5 xref: MetaCyc:3.4.23.5-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004193 name: obsolete cathepsin E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin E activity" EXACT [] synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "EMAP" RELATED [EC:3.4.23.34] synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] xref: EC:3.4.23.34 xref: MetaCyc:3.4.23.34-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004194 name: obsolete pepsin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] comment: This term was made obsolete because it represents a gene product. synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] synonym: "P I" RELATED [EC:3.4.23.1] synonym: "P II" RELATED [EC:3.4.23.1] synonym: "pepsin A activity" EXACT [] synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] xref: EC:3.4.23.1 xref: MetaCyc:3.4.23.1-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004195 name: obsolete renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] comment: This term was made obsolete because it represents a gene product. synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] synonym: "renin activity" EXACT [] xref: EC:3.4.23.15 xref: MetaCyc:3.4.23.15-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004196 name: obsolete saccharopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] comment: This term was made obsolete because it represents a gene product. synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] synonym: "PRA" RELATED [EC:3.4.23.25] synonym: "proteinase A" RELATED [EC:3.4.23.25] synonym: "proteinase yscA" RELATED [EC:3.4.23.25] synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "saccharopepsin activity" EXACT [] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] xref: EC:3.4.23.25 xref: MetaCyc:3.4.23.25-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "caspase activity" NARROW [GOC:mtg_apoptosis] synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "metacaspase activity" NARROW [GOC:mtg_apoptosis] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: reactome:R-HSA-114252 "Cleavage of Procaspase-3 by the apoptosome" xref: reactome:R-HSA-114259 "Cleavage of Procaspase9 to caspase9" xref: reactome:R-HSA-114261 "Cleavage of Procaspase-7 by the apoptosome" xref: reactome:R-HSA-1236948 "Antigen processing by cathepsin S in endosoytic vesicle" xref: reactome:R-HSA-139898 "Caspase-8 activates BID by cleavage" xref: reactome:R-HSA-139952 "Caspase-8 processing in the DISC" xref: reactome:R-HSA-1678920 "TLR processing at low pH" xref: reactome:R-HSA-1678981 "TLR9 processing at neutral pH" xref: reactome:R-HSA-201595 "Caspase-mediated cleavage of plakophilin-1" xref: reactome:R-HSA-201603 "Caspase-mediated cleavage of PKC theta" xref: reactome:R-HSA-201608 "Caspase-mediated cleavage of alpha adducin" xref: reactome:R-HSA-201611 "Caspase-mediated cleavage of Rock-1" xref: reactome:R-HSA-201622 "Caspase-mediated cleavage of gelsolin" xref: reactome:R-HSA-201628 "Caspase-mediated cleavage of vimentin at DSVD (85)" xref: reactome:R-HSA-201629 "Caspase-mediated cleavage of Tau" xref: reactome:R-HSA-201630 "Caspase-mediated cleavage of Acinus" xref: reactome:R-HSA-201631 "Caspase-mediated cleavage of Desmoglein 3" xref: reactome:R-HSA-201634 "Caspase-mediated cleavage of FADK 1" xref: reactome:R-HSA-201636 "Caspase-mediated cleavage of Desmoplakin" xref: reactome:R-HSA-201637 "Caspase-mediated cleavage of plectin-1" xref: reactome:R-HSA-201639 "Caspase-mediated cleavage of GAS2" xref: reactome:R-HSA-201640 "Caspase-mediated cleavage of farnesyltransferase/geranyl- geranyltransferase subunit alpha" xref: reactome:R-HSA-2028692 "Cleavage of p-STK4 (p-MST1) by caspase 3" xref: reactome:R-HSA-2028697 "Cleavage of p-STK3 (p-MST2) by caspase 3" xref: reactome:R-HSA-202917 "Caspase-mediated cleavage of Desmoglein 1" xref: reactome:R-HSA-202939 "Caspase-mediated cleavage of E-Cadherin" xref: reactome:R-HSA-202947 "Caspase mediated cleavage of APC" xref: reactome:R-HSA-202960 "Caspase mediated cleavage of C-IAP1" xref: reactome:R-HSA-202966 "Caspase mediated cleavage of HIP-55" xref: reactome:R-HSA-202967 "Caspase mediated cleavage of alpha-II-Fodrin" xref: reactome:R-HSA-202969 "Caspase mediated cleavage of beta-catenin" xref: reactome:R-HSA-211186 "Cleavage of DFF45 (224) by caspase-3" xref: reactome:R-HSA-211190 "Caspase 3-mediated cleavage of DFF45 (117)" xref: reactome:R-HSA-211651 "Cleavage of PAK-2 at 212" xref: reactome:R-HSA-212552 "Caspase 3-mediated cleavage of PKC delta" xref: reactome:R-HSA-2130336 "Initial proteolyis of Ii by aspartic proteases to lip22" xref: reactome:R-HSA-2130349 "Generation of CLIP from lip10" xref: reactome:R-HSA-2130504 "Cleavage of lip22 to lip10" xref: reactome:R-HSA-2130706 "MHC class II antigen processing" xref: reactome:R-HSA-2562564 "Caspase-8 processing within TLR4 complex" xref: reactome:R-HSA-264865 "Caspase-mediated cleavage of Lamin A" xref: reactome:R-HSA-264871 "Caspase-mediated cleavage of Lamin B1" xref: reactome:R-HSA-3465448 "Caspase-8 and FLIP(L) processing at DISC" xref: reactome:R-HSA-350158 "LGMN degrades GC" xref: reactome:R-HSA-350318 "Caspase-mediated cleavage of vimentin at TNLD (429)" xref: reactome:R-HSA-350319 "Caspase mediated cleavage of vimentin at IDVD (259)" xref: reactome:R-HSA-350651 "Caspase-mediated cleavage of MASK" xref: reactome:R-HSA-351849 "Caspase-mediated cleavage of Etk" xref: reactome:R-HSA-351871 "Caspase-mediated cleavage of Z0-2" xref: reactome:R-HSA-351876 "Caspase-mediated cleavage of occludin" xref: reactome:R-HSA-351877 "Caspase-mediated cleavage of Desmoglein 2" xref: reactome:R-HSA-351894 "Caspase mediated cleavage of BAP31" xref: reactome:R-HSA-351901 "Caspase-mediated cleavage of MST3" xref: reactome:R-HSA-351913 "Caspase-mediated cleavage of TJP1" xref: reactome:R-HSA-351936 "Caspase-mediated cleavage of claspin" xref: reactome:R-HSA-352268 "Cleavage of Satb1" xref: reactome:R-HSA-418845 "Activation of caspase-3" xref: reactome:R-HSA-418846 "Caspase cleavage of UNC5A" xref: reactome:R-HSA-418852 "Caspase cleavage of UNC5B" xref: reactome:R-HSA-448703 "Interleukin-1 family precursors are cleaved by caspase-1" xref: reactome:R-HSA-5357828 "RIP1 is cleaved by CASP8" xref: reactome:R-HSA-5634228 "TRAF1 is cleaved by caspases" xref: reactome:R-HSA-5660663 "Caspase-8 cleaves IL1B precursor" xref: reactome:R-HSA-5681987 "LC3 is cleaved by ATG4" xref: reactome:R-HSA-5682377 "LC3 de-lipidation by ATG4" xref: reactome:R-HSA-6814387 "CASP14 cleaves filaggrin" xref: reactome:R-HSA-9012556 "IL37:2x(CASP1(120-197):CASP1(317-404)) cleaves IL37" xref: reactome:R-HSA-9013895 "Caspase-8 processing within TLR3 complex" xref: reactome:R-HSA-933532 "Processing of caspases" xref: reactome:R-HSA-9603534 "Unknown caspase cleaves NTRK3" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004198 name: calcium-dependent cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] synonym: "calpain activity" NARROW [] xref: reactome:R-HSA-8848658 "CAPN:4xCa2+:CAPNS cleave cytoskeletal proteins" xref: reactome:R-HSA-8863012 "Calpain cleaves p35 to p25" is_a: GO:0004197 ! cysteine-type endopeptidase activity [Term] id: GO:0004200 name: obsolete signaling (initiator) caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "signaling (initiator) caspase activity" EXACT [] synonym: "signalling (initiator) caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004201 name: obsolete caspase-1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-1 activity" EXACT [] synonym: "ICE" BROAD [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004202 name: obsolete caspase-2 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-2 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004203 name: obsolete caspase-4 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-4 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004204 name: obsolete caspase-5 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-5 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004205 name: obsolete caspase-8 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-8 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004206 name: obsolete caspase-10 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-10 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004207 name: obsolete effector caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "effector caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004208 name: obsolete caspase-3 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-3 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004209 name: obsolete caspase-6 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-6 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004210 name: obsolete caspase-7 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-7 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004211 name: obsolete caspase-9 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "caspase-9 activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004212 name: obsolete lysosomal cysteine-type endopeptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "lysosomal cysteine-type endopeptidase" EXACT [] is_obsolete: true consider: GO:0004197 consider: GO:0005764 [Term] id: GO:0004213 name: obsolete cathepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin B activity" EXACT [] synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] xref: EC:3.4.22.1 xref: MetaCyc:3.4.22.1-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004214 name: obsolete dipeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] synonym: "DAP I" RELATED [EC:3.4.14.1] synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl-peptidase I activity" EXACT [] xref: EC:3.4.14.1 xref: MetaCyc:3.4.14.1-RXN is_obsolete: true consider: GO:0008234 consider: GO:0008239 [Term] id: GO:0004215 name: obsolete cathepsin H activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] comment: This term was made obsolete because it represents a gene product. synonym: "aleurain activity" EXACT [EC:3.4.22.16] synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "cathepsin H activity" EXACT [] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] xref: EC:3.4.22.16 xref: MetaCyc:3.4.22.16-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004216 name: obsolete cathepsin K activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin K activity" EXACT [] synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] xref: EC:3.4.22.38 xref: MetaCyc:3.4.22.38-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004217 name: obsolete cathepsin L activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] comment: This term was made obsolete because it represents a gene product. synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] synonym: "cathepsin L activity" EXACT [] xref: EC:3.4.22.15 xref: MetaCyc:3.4.22.15-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004218 name: obsolete cathepsin S activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin S activity" EXACT [] xref: EC:3.4.22.27 xref: MetaCyc:3.4.22.27-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004219 name: obsolete pyroglutamyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] comment: This term was made obsolete because it represents a gene product. synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "PYRase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl-peptidase I activity" EXACT [] synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] xref: EC:3.4.19.3 xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN is_obsolete: true consider: GO:0008234 consider: GO:0016920 [Term] id: GO:0004221 name: obsolete ubiquitin thiolesterase activity namespace: molecular_function alt_id: GO:0008577 def: "OBSOLETE. Catalysis of the reaction: ubiquitin C-terminal thioester + H2O = ubiquitin + a thiol." [EC:3.1.2.15, GOC:jh2] comment: This term was made obsolete because this molecular function does not exist. synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin thiolesterase activity" EXACT [] synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] xref: EC:3.1.2.15 xref: KEGG:R02418 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_obsolete: true consider: GO:0004843 consider: GO:0036459 [Term] id: GO:0004222 name: metalloendopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "metalloendoprotease activity" NARROW [GOC:mah] synonym: "metalloendoproteinase activity" NARROW [GOC:mah] xref: EC:3.4.24 xref: reactome:R-HSA-1168777 "Metalloprotease cleavage of GHR" xref: reactome:R-HSA-1251992 "Cleavage of P-ERBB4jmA isoforms by ADAM17" xref: reactome:R-HSA-1299476 "MPP cleaves targeting peptide (presequence) of inner membrane precursors" xref: reactome:R-HSA-1299478 "MPP cleaves targeting peptide (presequence) of matrix precursors" xref: reactome:R-HSA-1454757 "Gelatin degradation by MMP1, 2, 3, 7, 8, 9, 12, 13" xref: reactome:R-HSA-1454822 "Collagen type I degradation by MMP1,2,8,13, PRSS2" xref: reactome:R-HSA-1458433 "Collagen type I degradation by MMP14" xref: reactome:R-HSA-1474196 "Collagen type II degradation by MMP14" xref: reactome:R-HSA-1474210 "Collagen type III degradation by MMP14" xref: reactome:R-HSA-1474213 "Collagen type III degradation by MMP1,8,9,13" xref: reactome:R-HSA-1564112 "Collagen type VI degradation by MMP2,9,11" xref: reactome:R-HSA-1564117 "Collagen type XIV degradation by MMP9,13" xref: reactome:R-HSA-1564120 "Collagen type VII degradation by MMP1,2,3" xref: reactome:R-HSA-1564142 "Collagen type IV degradation by MMP2,3,4,9,10,12" xref: reactome:R-HSA-1564143 "Collagen type X degradation by MMP1,2" xref: reactome:R-HSA-1564164 "Collagen type V degradation by MMP2,9,10" xref: reactome:R-HSA-1564169 "Collagen type VIII degradation by MMP1" xref: reactome:R-HSA-1564179 "Collagen type XI degradation by MMP1,2,3,9" xref: reactome:R-HSA-1564184 "Collagen type IX degradation by MMP3,13" xref: reactome:R-HSA-1592310 "Aggrecan degradation by ADAMTSs" xref: reactome:R-HSA-1655851 "S2P hydrolyzes SREBP1A,1C,2" xref: reactome:R-HSA-177946 "Pro-EGF is cleaved to form mature EGF" xref: reactome:R-HSA-181567 "BoNT/C LC cleaves target cell STX1" xref: reactome:R-HSA-194793 "BoNT/C LC cleaves target cell SNAP25" xref: reactome:R-HSA-194796 "BoNT/B LC cleaves target cell VAMP2" xref: reactome:R-HSA-194800 "BoNT/E LC cleaves target cell SNAP25" xref: reactome:R-HSA-194808 "BoNT/F LC cleaves target cell VAMP1" xref: reactome:R-HSA-194809 "BoNT/D LC cleaves target cell VAMP1" xref: reactome:R-HSA-194818 "BoNT/A LC cleaves target cell SNAP25" xref: reactome:R-HSA-2002428 "Removal of fibrillar collagen N-propeptides" xref: reactome:R-HSA-2002440 "Removal of fibrillar collagen C-propeptides" xref: reactome:R-HSA-2022141 "Prolysyl oxidase activation" xref: reactome:R-HSA-2168046 "Collagen type XII degradation by MMP12" xref: reactome:R-HSA-2168982 "Collagen type XVI degradation by MMP9" xref: reactome:R-HSA-2179402 "Active MMP3 can cleave pro-HBEGF to form active HBEGF" xref: reactome:R-HSA-2473584 "Collagen type III degradation by MMP15" xref: reactome:R-HSA-2473594 "Collagen type II degradation by MMP15" xref: reactome:R-HSA-2473596 "Collagen type I degradation by MMP15" xref: reactome:R-HSA-2484882 "Collagen type X degradation by MMP3, 13" xref: reactome:R-HSA-2485111 "Collagen type III degradation by MMP10" xref: reactome:R-HSA-2485148 "Fibrillin 1, 2,(3) degradation by MMP2, 9, 12 and 13" xref: reactome:R-HSA-2514790 "Elastin degradation by MMP14" xref: reactome:R-HSA-2514831 "Fibrillin-1 degradation by MMP14" xref: reactome:R-HSA-2533874 "Laminin-511 degradation by MMP14" xref: reactome:R-HSA-2533944 "Fibronectin degradation by MMP10" xref: reactome:R-HSA-2533950 "Fibronectin degradation by MMP14, TMPRSS6" xref: reactome:R-HSA-2533965 "NID1 degradation by MMP14, MMP15" xref: reactome:R-HSA-2533970 "NID1 degradation by MMP3, 7" xref: reactome:R-HSA-2534240 "HSPG2 (perlecan) degradation by MMP14, MMP15" xref: reactome:R-HSA-2534248 "DCN (decorin) degradation by MMP2, MMP3, MMP7" xref: reactome:R-HSA-2537499 "Gelatin degradation by MMP19" xref: reactome:R-HSA-264758 "BMP1-3:Zn2+ cleaves pro-APOA1 to APOA1" xref: reactome:R-HSA-3371385 "TNF-alpha is cleaved by ADAM17 (TACE)" xref: reactome:R-HSA-3788075 "Brevican degradation by ADAMTS4, ADAMTS5" xref: reactome:R-HSA-3791149 "Brevican degradation by MMP1, 2, 3, 7,8,10,13,19" xref: reactome:R-HSA-3791155 "Laminin-322 degradation by MMP14" xref: reactome:R-HSA-3791295 "Aggrecan degradation by MMP1,2,3,7,9,12,13" xref: reactome:R-HSA-3791319 "NID1 degradation by MMP19" xref: reactome:R-HSA-381435 "Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS" xref: reactome:R-HSA-381518 "PAAP-A proteolyzes IGF:IGFBP4" xref: reactome:R-HSA-381537 "PAPP-A2 proteolyzes IGF:IGFBP5:ALS" xref: reactome:R-HSA-3827958 "E-cadherin degradation by MMP9, KLK7" xref: reactome:R-HSA-3828025 "DCN (decorin) degradation by MMP14" xref: reactome:R-HSA-4086205 "OPN (osteopontin) degradation by MMP3, MMP7" xref: reactome:R-HSA-420818 "MBTPS2 (S2P) cleaves ATF6 (ATF6-alpha)" xref: reactome:R-HSA-4224014 "E-cadherin degradation by ADAM10, ADAM15" xref: reactome:R-HSA-5228578 "TeNT LC cleaves target cell VAMP2" xref: reactome:R-HSA-5250606 "BoNT/D LC cleaves target cell VAMP2" xref: reactome:R-HSA-5250892 "BoNT/F LC cleaves target cell VAMP2" xref: reactome:R-HSA-5250962 "BoNT/G LC cleaves target cell VAMP2" xref: reactome:R-HSA-5250978 "BoNT/G LC cleaves target cell VAMP1" xref: reactome:R-HSA-5333671 "CLCAs self cleave" xref: reactome:R-HSA-5362793 "Hh-Np is cleaved by ADAM17 to promote ligand shedding" xref: reactome:R-HSA-5694082 "XK:KEL:Zn2+ cleaves EDN3" xref: reactome:R-HSA-6784620 "MBTPS1,2 cleaves CREB3L3 to CREB3L3(1-?) and CREB3L3(?-461)" xref: reactome:R-HSA-8867344 "OMA1 hydrolyses OPA1" xref: reactome:R-HSA-8874187 "MBTPS2 (S2P) cleaves CREB3L2" xref: reactome:R-HSA-8874192 "MBTPS2 (S2P) cleaves CREB3" xref: reactome:R-HSA-8874194 "MBTPS2 (S2P) cleaves CREB3L1" xref: reactome:R-HSA-8874195 "MBTPS2 (S2P) cleaves CREB3L4" xref: reactome:R-HSA-8874201 "MBTPS2 (S2P) cleaves CREB3L3" xref: reactome:R-HSA-8876868 "ECE1 cleaves EDN1(53-90)" xref: reactome:R-HSA-8877620 "ECE2 cleaves EDN1(53-90)" xref: reactome:R-HSA-8940554 "MMP2 cleaves OPTC" xref: reactome:R-HSA-8940561 "MMP7 cleaves OPTC" xref: reactome:R-HSA-8940641 "THOP1 cleaves oligopeptide fragment (8-16aa)" xref: reactome:R-HSA-8940959 "Neurolysin degrades neurotensin" xref: reactome:R-HSA-8942302 "MMP13 cleaves OPTC" xref: reactome:R-HSA-8943959 "MMP2, MMP9 cleave SCUBE3" xref: reactome:R-HSA-8949649 "PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)" xref: reactome:R-HSA-8949659 "AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU" xref: reactome:R-HSA-8949668 "YME1L1 proteolyzes unassembled proSMDT1" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008237 ! metallopeptidase activity [Term] id: GO:0004226 name: obsolete Gly-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] synonym: "Gly-X carboxypeptidase activity" EXACT [] synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] xref: EC:3.4.17.4 xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004228 name: obsolete gelatinase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] comment: This term was made obsolete because it represents a gene product. synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] synonym: "collagenase IV" RELATED [EC:3.4.24.24] synonym: "collagenase type IV" RELATED [EC:3.4.24.24] synonym: "gelatinase A activity" EXACT [] synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] synonym: "MMP 2" RELATED [EC:3.4.24.24] synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] xref: EC:3.4.24.24 xref: MetaCyc:3.4.24.24-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004229 name: obsolete gelatinase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] comment: This term was made obsolete because it represents a gene product. synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] synonym: "collagenase IV" RELATED [EC:3.4.24.35] synonym: "collagenase type IV" RELATED [EC:3.4.24.35] synonym: "gelatinase B activity" EXACT [] synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] xref: EC:3.4.24.35 xref: MetaCyc:3.4.24.35-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004230 name: obsolete glutamyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "glutamyl aminopeptidase activity" EXACT [] synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] xref: EC:3.4.11.7 xref: MetaCyc:3.4.11.7-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004231 name: obsolete insulysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] comment: This term was made obsolete because it represents a gene product. synonym: "IDE" RELATED [EC:3.4.24.56] synonym: "insulin protease activity" EXACT [EC:3.4.24.56] synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "insulysin activity" EXACT [] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] xref: EC:3.4.24.56 xref: MetaCyc:3.4.24.56-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004232 name: obsolete interstitial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] comment: This term was made obsolete because it represents a gene product. synonym: "interstitial collagenase activity" EXACT [] synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] xref: EC:3.4.24.7 xref: MetaCyc:3.4.24.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004234 name: obsolete macrophage elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] comment: This term was made obsolete because it represents a gene product. synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] synonym: "macrophage elastase activity" EXACT [] synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] synonym: "metalloesterase activity" EXACT [] synonym: "MMP-12" EXACT [] xref: EC:3.4.24.65 xref: MetaCyc:3.4.24.65-RXN is_obsolete: true consider: GO:0004175 consider: GO:0004222 [Term] id: GO:0004235 name: obsolete matrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] comment: This term was made obsolete because it represents a gene product. synonym: "matrilysin activity" EXACT [] synonym: "matrin activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] synonym: "MMP" RELATED [EC:3.4.24.23] synonym: "MMP 7" RELATED [EC:3.4.24.23] synonym: "MMP-7" EXACT [] synonym: "PUMP" RELATED [EC:3.4.24.23] synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] xref: EC:3.4.24.23 xref: MetaCyc:3.4.24.23-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004237 name: obsolete membrane dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] comment: This term was made obsolete because it represents a gene product. synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] synonym: "DPH I activity" NARROW [EC:3.4.13.19] synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "MDP" RELATED [EC:3.4.13.19] synonym: "membrane dipeptidase activity" EXACT [] synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] xref: EC:3.4.13.19 xref: MetaCyc:3.4.13.19-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0004238 name: obsolete meprin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] comment: This term was made obsolete because it represents a gene product. synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] synonym: "meprin" RELATED [EC:3.4.24.18] synonym: "meprin A activity" EXACT [] synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] xref: EC:3.4.24.18 xref: MetaCyc:3.4.24.18-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004239 name: obsolete methionyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] comment: This term was made obsolete because it represents a gene product. synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "MAP" RELATED [EC:3.4.11.18] synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "methionyl aminopeptidase activity" EXACT [] synonym: "peptidase M activity" EXACT [EC:3.4.11.18] xref: EC:3.4.11.18 xref: MetaCyc:3.4.11.18-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 consider: GO:0070084 [Term] id: GO:0004240 name: obsolete mitochondrial processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" NARROW [] synonym: "beta-mitochondrial processing peptidase" NARROW [] synonym: "matrix peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] synonym: "mitochondrial processing peptidase activity" EXACT [] synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] xref: EC:3.4.24.64 xref: MetaCyc:3.4.24.64-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004241 name: obsolete alpha-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" EXACT [] synonym: "alpha-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004242 name: obsolete beta-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "beta-mitochondrial processing peptidase" EXACT [] synonym: "beta-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004243 name: obsolete mitochondrial intermediate peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] comment: This term was made obsolete because it represents a gene product. synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate peptidase activity" EXACT [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] xref: EC:3.4.24.59 xref: MetaCyc:3.4.24.59-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004244 name: obsolete mitochondrial inner membrane peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] comment: This term was made obsolete because it represents a gene product. synonym: "IMP" BROAD [] synonym: "mitochondrial inner membrane peptidase activity" EXACT [] xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0004245 name: obsolete neprilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] comment: This term was made obsolete because it represents a gene product. synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "CALLA" RELATED [EC:3.4.24.11] synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] synonym: "CALLA antigen" RELATED [EC:3.4.24.11] synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] synonym: "CD10" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] synonym: "neprilysin activity" EXACT [] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] xref: EC:3.4.24.11 xref: MetaCyc:3.4.24.11-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004246 name: obsolete peptidyl-dipeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] comment: This term was made obsolete because it represents a gene product. synonym: "ACE activity" BROAD [] synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] synonym: "DCP" RELATED [EC:3.4.15.1] synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] synonym: "kininase II activity" EXACT [EC:3.4.15.1] synonym: "PDH" RELATED [EC:3.4.15.1] synonym: "peptidase P activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyl-dipeptidase A activity" EXACT [] synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] xref: EC:3.4.15.1 xref: MetaCyc:3.4.15.1-RXN is_obsolete: true consider: GO:0008237 consider: GO:0008241 [Term] id: GO:0004247 name: obsolete saccharolysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] comment: This term was made obsolete because it represents a gene product. synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharolysin activity" EXACT [] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] xref: EC:3.4.24.37 xref: MetaCyc:3.4.24.37-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004248 name: obsolete stromelysin 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] comment: This term was made obsolete because it represents a gene product. synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] synonym: "MMP-3" EXACT [] synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "procollagenase activator" RELATED [EC:3.4.24.17] synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "stromelysin 1 activity" EXACT [] synonym: "transin activity" EXACT [EC:3.4.24.17] xref: EC:3.4.24.17 xref: MetaCyc:3.4.24.17-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004249 name: obsolete stromelysin 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] synonym: "stromelysin 3 activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004250 name: obsolete aminopeptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase I activity" EXACT [] synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] xref: EC:3.4.11.22 xref: MetaCyc:3.4.11.22-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0004251 name: obsolete X-Pro dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] comment: This term was made obsolete because it represents a gene product. synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] synonym: "peptidase D" RELATED [EC:3.4.13.9] synonym: "prolidase activity" EXACT [EC:3.4.13.9] synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] synonym: "X-Pro dipeptidase activity" EXACT [] synonym: "Xaa-Pro dipeptidase activity" EXACT [] xref: EC:3.4.13.9 xref: MetaCyc:3.4.13.9-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] subset: goslim_chembl synonym: "blood coagulation factor activity" RELATED [] synonym: "serine elastase activity" RELATED [GOC:krc] xref: EC:3.4.21 xref: reactome:R-HSA-114697 "Thrombin-mediated activation of Proteinase-activated receptors" xref: reactome:R-HSA-1181152 "Cleavage of NODAL proprotein" xref: reactome:R-HSA-139893 "Granzyme-B activates BID by cleavage" xref: reactome:R-HSA-140599 "factor XIII -> factor XIII cleaved tetramer + 2 factor XIII A activation peptides" xref: reactome:R-HSA-140664 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (prothrombinase catalyst)" xref: reactome:R-HSA-140696 "factor V -> factor Va + factor V activation peptide" xref: reactome:R-HSA-140700 "prothrombin -> activated thrombin (factor IIa) + thrombin activation peptide (Xa catalyst)" xref: reactome:R-HSA-140736 "factor X -> factor Xa + factor X activation peptide (TF:F7a catalyst)" xref: reactome:R-HSA-140769 "factor VII -> factor VIIa" xref: reactome:R-HSA-140777 "factor X -> factor Xa + factor X activation peptide (TF:F7 catalyst)" xref: reactome:R-HSA-140823 "factor IX -> factor IXa + factor IX activation peptide (TF:F7a catalyst)" xref: reactome:R-HSA-140840 "fibrinogen -> fibrin monomer + 2 fibrinopeptide A + 2 fibrinopeptide B" xref: reactome:R-HSA-140870 "thrombin:antithrombin III:heparin -> thrombin:cleaved antithrombin III:heparin" xref: reactome:R-HSA-141026 "Activated protein C cleaves factor Va to factor Vi intermediate form" xref: reactome:R-HSA-141040 "Activated thrombin:thrombomodulin cleaves PROCR:Protein C to PROCR:Activated protein C" xref: reactome:R-HSA-1454843 "E-cadherin degradation by MMP3, MMP7 and plasmin." xref: reactome:R-HSA-1474197 "Collagen type II degradation by MMP1,3,8,13,PRSS2" xref: reactome:R-HSA-1566962 "Elastin degradation by elastin-degrading extracellular proteinases" xref: reactome:R-HSA-1566979 "Laminin-332 degradation by laminin-322 degrading extracellular proteinases" xref: reactome:R-HSA-1566981 "Fibronectin degradation by MMP1, 3, 7, 12, 13, 19, CTSS" xref: reactome:R-HSA-158137 "factor VIII:von Willibrand factor multimer -> factor VIIIa + factor VIIIa B A3 acidic polypeptide + von Willibrand factor multimer" xref: reactome:R-HSA-158164 "factor X -> factor Xa + factor X activation peptide (VIIIa:IXa catalyst)" xref: reactome:R-HSA-158300 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst)" xref: reactome:R-HSA-158311 "kallikrein:kininogen:C1q binding protein tetramer -> kallikrein + activated kininogen:C1q binding protein tetramer + bradykinin" xref: reactome:R-HSA-158313 "factor XII -> factor XIIa" xref: reactome:R-HSA-158333 "factor IX -> factor IXa + factor IX activation peptide (factor XIa catalyst)" xref: reactome:R-HSA-158419 "factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst)" xref: reactome:R-HSA-158744 "crosslinked fibrin multimer:tissue plasminogen activator (two-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain) + plasmin" xref: reactome:R-HSA-158747 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain) -> crosslinked fibrin multimer:tissue plasminogen activator (two-chain)" xref: reactome:R-HSA-158750 "crosslinked fibrin multimer:tissue plasminogen activator (one-chain):plasminogen -> crosslinked fibrin multimer:tissue plasminogen activator (one-chain) + plasmin" xref: reactome:R-HSA-158766 "fibrin multimer, crosslinked -> fibrin digestion products (plasmin)" xref: reactome:R-HSA-158925 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [two-chain] catalyst)" xref: reactome:R-HSA-158942 "urokinase plasminogen activator (one-chain):uPAR -> urokinase plasminogen activator (two-chain):uPAR" xref: reactome:R-HSA-158982 "plasminogen:histidine-rich glycoprotein -> plasmin + histidine-rich glycoprotein (uPA [one-chain] catalyst)" xref: reactome:R-HSA-1592270 "NID1 degradation by MMP1, 9, 12, ELANE" xref: reactome:R-HSA-1592278 "Autocatalytic activation of proMMP2" xref: reactome:R-HSA-1592297 "Full activation of MMP1" xref: reactome:R-HSA-1592314 "HSPG2 (perlecan) degradation by MMP3, plasmin, (MMP12)" xref: reactome:R-HSA-1592316 "Initial activation of proMMP1" xref: reactome:R-HSA-1592362 "Activation of proMMP7 by MMP3" xref: reactome:R-HSA-1592371 "Initial activation of proMMP3" xref: reactome:R-HSA-1592398 "Activation of proMMP8" xref: reactome:R-HSA-1592436 "Initial activation of proMMP9 by MMPs" xref: reactome:R-HSA-159728 "Furin cleaves pro-prothrombin to prothrombin" xref: reactome:R-HSA-159733 "Furin cleaves pro-factor X to factor X" xref: reactome:R-HSA-159771 "Furin cleaves pro-protein C to protein C" xref: reactome:R-HSA-159773 "Furin cleaves pro-protein S to protein S" xref: reactome:R-HSA-159796 "Furin cleaves pro-factor IX to factor IX" xref: reactome:R-HSA-159868 "Furin cleaves pro-factor VII to factor VII" xref: reactome:R-HSA-1602458 "Activation of proMMP10" xref: reactome:R-HSA-1602466 "Activation of MT-MMPs by FURIN" xref: reactome:R-HSA-1602473 "Autocatalytic activation of MMP1" xref: reactome:R-HSA-1602484 "Activation of proMMP11 by FURIN" xref: reactome:R-HSA-1602488 "Initial activation of proMMP13 by plasmin and trypsin" xref: reactome:R-HSA-1604359 "Initial activation of proMMP2 by MMP1, 7" xref: reactome:R-HSA-1604360 "Initial activation of proMMP2 by MMP14" xref: reactome:R-HSA-1604368 "Autocatalytic activation of bound proMMP2" xref: reactome:R-HSA-1604690 "Activation of MMP9 intermediate form by MMPs" xref: reactome:R-HSA-1604712 "Initial activation of proMMP7 by trypsin" xref: reactome:R-HSA-1604722 "Activation of proMMP9 by proteases" xref: reactome:R-HSA-1604731 "Autocatalytic activation of MMP3" xref: reactome:R-HSA-1604732 "Autocatalytic activation of proMMP13" xref: reactome:R-HSA-1604741 "Initial activation of proMMP13 by MMP14 (MT1-MMP)" xref: reactome:R-HSA-1604752 "Initial activation of proMMP13 by MMP3" xref: reactome:R-HSA-1604763 "Autocatalytic activation of MMP7" xref: reactome:R-HSA-163798 "Furin cleaves pro-protein Z to protein Z" xref: reactome:R-HSA-163843 "Furin cleaves pro-GAS6 to GAS6" xref: reactome:R-HSA-1655842 "S1P hydrolyzes SREBP1A,1C,2" xref: reactome:R-HSA-166753 "Conversion of C4 into C4a and C4b" xref: reactome:R-HSA-166792 "Conversion of C2 into C2a and C2b" xref: reactome:R-HSA-166817 "Cleavage of C3 by C3 convertases" xref: reactome:R-HSA-170844 "Latent TGF-beta-1 is cleaved by furin" xref: reactome:R-HSA-171288 "Cleavage of the viral Env gp160 precursor polyprotein" xref: reactome:R-HSA-173626 "Activation of C1r" xref: reactome:R-HSA-173631 "Activation of C1s" xref: reactome:R-HSA-173680 "Activation of C5" xref: reactome:R-HSA-173745 "Factor D cleaves C3(H2O)-bound Factor B" xref: reactome:R-HSA-174551 "Formation of alternative pathway C5 convertase" xref: reactome:R-HSA-1799329 "Signal peptidase hydrolyzes signal peptide from ribosome-associated nascent protein" xref: reactome:R-HSA-183122 "Factor D cleaves C3b-bound Factor B" xref: reactome:R-HSA-183130 "C3(H2O):Factor Bb cleaves C3 to C3b and C3a" xref: reactome:R-HSA-186785 "PDGF-AA clevage by Furin" xref: reactome:R-HSA-187020 "Part of pro-beta-NGF is processed to mature beta-NGF" xref: reactome:R-HSA-1912369 "NOTCH precursor cleaved to form mature NOTCH" xref: reactome:R-HSA-1912372 "Fringe-modified Pre-NOTCH is cleaved by FURIN" xref: reactome:R-HSA-2022411 "Cathepsin G hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: reactome:R-HSA-2129357 "Fibrillin C-terminal processing" xref: reactome:R-HSA-2168923 "Collagen type XVIII endostatin release" xref: reactome:R-HSA-2168960 "Collagen type XVII ectodomain shedding" xref: reactome:R-HSA-2172405 "Collagen type XXIII ectodomain shedding" xref: reactome:R-HSA-2214330 "Cleavage of collagen VII NC2 region by BMP1" xref: reactome:R-HSA-2471621 "Endostatin degradation by cathepsins" xref: reactome:R-HSA-2471842 "Collagen type XXV ectomain shedding" xref: reactome:R-HSA-2482180 "Collagen type VIII degradation by ELANE" xref: reactome:R-HSA-2514772 "Fibrillin-1 degradation by MMP3, CTSK, CTSL2" xref: reactome:R-HSA-2514823 "Fibrillin-1 degradation by ELANE" xref: reactome:R-HSA-2534160 "HSPG2 (perlecan) degradation by MMP13, CTSS" xref: reactome:R-HSA-2534206 "E-cadherin degradation by PS1:NCSTN (Gamma-secretase)" xref: reactome:R-HSA-2534260 "E-cadherin degradation by caspase-3 and calpain-1" xref: reactome:R-HSA-265301 "Corticotropin cleavage from POMC" xref: reactome:R-HSA-3266557 "Factor I cleaves iC3b" xref: reactome:R-HSA-3785684 "Fibronectin degradation by CTSG" xref: reactome:R-HSA-3788061 "Fibronectin degradation by ADAM8" xref: reactome:R-HSA-381135 "MBTPS1 (S1P) cleaves ATF6 (ATF6-alpha)" xref: reactome:R-HSA-381446 "Thrombin proteolyzes IGF:IGFBP3:ALS" xref: reactome:R-HSA-381461 "Plasmin proteolyzes IGF:IGFBP-3:ALS" xref: reactome:R-HSA-381466 "Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS" xref: reactome:R-HSA-3814820 "HSPG2 (perlecan) is cleaved by BMP1, TLL1, TLL2, Cathepsin L1" xref: reactome:R-HSA-381500 "Cathepsin G proteolyzes IGF:IGFBP3:ALS" xref: reactome:R-HSA-381798 "PCSK1 hydrolyzes Proglucagon to Glucagon-like Peptide-1" xref: reactome:R-HSA-382061 "Extracellular processing of novel PDGFs" xref: reactome:R-HSA-3928657 "MMP2,9 cleave EPHB" xref: reactome:R-HSA-400459 "Signal peptidase hydrolyzes preproGLP-1 to proGLP-1" xref: reactome:R-HSA-400492 "PCSK1 hydrolyzes proGIP to GIP" xref: reactome:R-HSA-400496 "Signal peptidase hydrolyzes preproGIP to proGIP" xref: reactome:R-HSA-422021 "PCSK1 hydrolyzes acyl Proghrelin to acyl Ghrelin" xref: reactome:R-HSA-422051 "Cleavage of the signal peptide of Preproghrelin" xref: reactome:R-HSA-5210912 "Furin cleaves ANTXR2-bound PA83 to yield PA63" xref: reactome:R-HSA-5210935 "Furin cleaves ANTXR1-bound PA83 to yield PA63" xref: reactome:R-HSA-5578783 "CORIN(802-1042) hydrolyses NPPA to form NPPA(124-151)" xref: reactome:R-HSA-5591040 "Activated protein C cleaves Factor Va intermediate form for Factor Va" xref: reactome:R-HSA-5607002 "Activated protein C cleaves factor VIIIa" xref: reactome:R-HSA-5691512 "APEH hydrolyses NAc-Ser-protein" xref: reactome:R-HSA-6800198 "HPN heterodimer cleaves pro-MST1 to form MST1 dimer" xref: reactome:R-HSA-6800200 "HPN heterodimer cleaves pro-HGF to form HGF dimer" xref: reactome:R-HSA-6800299 "HGFAC cleaves pro-HGF to form HGF dimer" xref: reactome:R-HSA-6801687 "PRTN3 cleaves CAMP(31-170) to generate CAMP(134-170)" xref: reactome:R-HSA-6807224 "Furin cleaves pro-BGLAP to BGLAP" xref: reactome:R-HSA-8849826 "ST14 hydrolyzes and activates KLK5" xref: reactome:R-HSA-8849857 "KLK5 cleaves and activates CELA2" xref: reactome:R-HSA-8850831 "KLK5 cleaves and activates KLK8" xref: reactome:R-HSA-8852716 "Thrombin, ELANE cleave C5" xref: reactome:R-HSA-8855825 "HTRA1 hydrolyzes ACAN (Aggrecan)" xref: reactome:R-HSA-8865275 "PDGF-BB clevage by Furin" xref: reactome:R-HSA-8865276 "PDGF-AB clevage by Furin" xref: reactome:R-HSA-8874186 "MBTPS1 (S1P) cleaves CREB3L4" xref: reactome:R-HSA-8874204 "MBTPS1 (S1P) cleaves CREB3" xref: reactome:R-HSA-8874205 "MBTPS1 (S1P) cleaves CREB3L2" xref: reactome:R-HSA-8874206 "MBTPS1 (S1P) cleaves CREB3L3" xref: reactome:R-HSA-8874212 "MBTPS1 (S1P) cleaves CREB3L1" xref: reactome:R-HSA-9023178 "PCSK2 cleaves Insulin(57-110) to yield Insulin(90-110) and C-peptide (Insulin(57-89))" xref: reactome:R-HSA-9023196 "PCSK1 cleaves proinsulin to yield Insulin(25-56) and Insulin(57-110)" xref: reactome:R-HSA-9023626 "DPP4(39-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: reactome:R-HSA-9023627 "DPP4(1-766) hydrolyzes Glucose-dependent Insulinotropic Polypeptide (GIP)" xref: reactome:R-HSA-9023632 "DPP4(39-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: reactome:R-HSA-9023633 "DPP4(1-766) hydrolyzes Glucagon-like Peptide-1 (GLP-1)" xref: reactome:R-HSA-9033490 "TYSND1 cleaves PHYH" xref: reactome:R-HSA-9033506 "TYSND1 cleaves AGPS" xref: reactome:R-HSA-9033515 "TYSND1 cleaves ACOX1" xref: reactome:R-HSA-9033520 "TYSND1 cleaves TYSND1" xref: reactome:R-HSA-9033524 "TYSND1 cleaves SCP2" xref: reactome:R-HSA-9033529 "TYSND1 cleaves ACAA1" xref: reactome:R-HSA-9033530 "TYSND1 cleaves HSD17B4" xref: reactome:R-HSA-976743 "Factor I inactivates plasma Factor H-bound C3b" xref: reactome:R-HSA-977371 "Factor I inactivates Factor H-boundC3b" xref: reactome:R-HSA-977615 "Factor I inactivates MCP/CR1-bound C4b/C3b" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008236 ! serine-type peptidase activity [Term] id: GO:0004253 name: obsolete gamma-renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] comment: This term was made obsolete because it represents a gene product. synonym: "gamma-renin activity" EXACT [] xref: EC:3.4.21.54 xref: MetaCyc:3.4.21.54-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004254 name: obsolete acylaminoacyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] synonym: "acylaminoacyl-peptidase activity" EXACT [] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] xref: EC:3.4.19.1 xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004258 name: obsolete vacuolar carboxypeptidase Y namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it contains both component and function information. synonym: "vacuolar carboxypeptidase Y" EXACT [] is_obsolete: true consider: GO:0004185 consider: GO:0005773 [Term] id: GO:0004261 name: obsolete cathepsin G activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin G activity" EXACT [] synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] xref: EC:3.4.21.20 xref: MetaCyc:3.4.21.20-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004262 name: obsolete cerevisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] comment: This term was made obsolete because it represents a gene product. synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] synonym: "cerevisin activity" EXACT [] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] xref: EC:3.4.21.48 xref: MetaCyc:3.4.21.48-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004263 name: obsolete chymotrypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-chymar" RELATED [EC:3.4.21.1] synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] synonym: "avazyme" RELATED [EC:3.4.21.1] synonym: "chymar" RELATED [EC:3.4.21.1] synonym: "chymotest" RELATED [EC:3.4.21.1] synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsin activity" EXACT [] synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] xref: EC:3.4.21.1 xref: MetaCyc:3.4.21.1-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004274 name: obsolete dipeptidyl-peptidase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] comment: This term was made obsolete because it represents a gene product. synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-peptidase IV activity" EXACT [] synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] synonym: "DPP IV activity" EXACT [EC:3.4.14.5] synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "pep X" RELATED [EC:3.4.14.5] synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] synonym: "X-PDAP" RELATED [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] xref: EC:3.4.14.5 xref: MetaCyc:3.4.14.5-RXN is_obsolete: true consider: GO:0008236 consider: GO:0008239 [Term] id: GO:0004275 name: obsolete enteropeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] comment: This term was made obsolete because it represents a gene product. synonym: "enterokinase activity" RELATED [EC:3.4.21.9] synonym: "enteropeptidase activity" EXACT [] xref: EC:3.4.21.9 xref: MetaCyc:3.4.21.9-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004276 name: obsolete furin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] comment: This term was made obsolete because it represents a gene product. synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] synonym: "furin activity" EXACT [] synonym: "PACE" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] xref: EC:3.4.21.75 xref: MetaCyc:3.4.21.75-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004277 name: obsolete granzyme A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] comment: This term was made obsolete because it represents a gene product. synonym: "CTLA3" RELATED [EC:3.4.21.78] synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] synonym: "granzyme A activity" EXACT [] synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] xref: EC:3.4.21.78 xref: MetaCyc:3.4.21.78-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004278 name: obsolete granzyme B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] comment: This term was made obsolete because it represents a gene product. synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] synonym: "CCPII" RELATED [EC:3.4.21.79] synonym: "CTLA1" RELATED [EC:3.4.21.79] synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme B activity" EXACT [] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] xref: EC:3.4.21.79 xref: MetaCyc:3.4.21.79-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004281 name: obsolete pancreatic elastase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] synonym: "pancreatic elastase II activity" EXACT [] xref: EC:3.4.21.71 xref: MetaCyc:3.4.21.71-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004283 name: obsolete plasmin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] comment: This term was made obsolete because it represents a gene product. synonym: "actase activity" EXACT [EC:3.4.21.7] synonym: "fibrinase activity" EXACT [EC:3.4.21.7] synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "plasmin activity" EXACT [] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] xref: EC:3.4.21.7 xref: MetaCyc:3.4.21.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004284 name: obsolete acrosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] comment: This term was made obsolete because it represents a gene product. synonym: "acrosin activity" EXACT [] synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] xref: EC:3.4.21.10 xref: MetaCyc:3.4.21.10-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004285 name: obsolete proprotein convertase 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] synonym: "proprotein convertase 1 activity" EXACT [] xref: EC:3.4.21.93 xref: MetaCyc:3.4.21.93-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004286 name: obsolete proprotein convertase 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] synonym: "proprotein convertase 2 activity" EXACT [] xref: EC:3.4.21.94 xref: MetaCyc:3.4.21.94-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004287 name: obsolete prolyl oligopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] comment: This term was made obsolete because it represents a gene product. synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl oligopeptidase activity" EXACT [] xref: EC:3.4.21.26 xref: MetaCyc:3.4.21.26-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004289 name: obsolete subtilase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "subtilase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004290 name: obsolete kexin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] comment: This term was made obsolete because it represents a gene product. synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 protease" NARROW [EC:3.4.21.61] synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] synonym: "kexin activity" EXACT [] synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] synonym: "protease KEX2" RELATED [EC:3.4.21.61] synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] xref: EC:3.4.21.61 xref: MetaCyc:3.4.21.61-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004291 name: obsolete subtilisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] comment: This term was made obsolete because it represents a gene product. synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] synonym: "alcalase activity" EXACT [EC:3.4.21.62] synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] synonym: "colistinase activity" EXACT [EC:3.4.21.62] synonym: "esperase activity" EXACT [EC:3.4.21.62] synonym: "genenase I" RELATED [EC:3.4.21.62] synonym: "kazusase activity" EXACT [EC:3.4.21.62] synonym: "maxatase activity" EXACT [EC:3.4.21.62] synonym: "opticlean" RELATED [EC:3.4.21.62] synonym: "orientase 10B" RELATED [EC:3.4.21.62] synonym: "protease S" RELATED [EC:3.4.21.62] synonym: "protease VIII" RELATED [EC:3.4.21.62] synonym: "protease XXVII" RELATED [EC:3.4.21.62] synonym: "protin A 3L" RELATED [EC:3.4.21.62] synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] synonym: "savinase activity" EXACT [EC:3.4.21.62] synonym: "SP 266" RELATED [EC:3.4.21.62] synonym: "subtilisin activity" EXACT [] synonym: "subtilisin BL" RELATED [EC:3.4.21.62] synonym: "subtilisin DY" RELATED [EC:3.4.21.62] synonym: "subtilisin E" RELATED [EC:3.4.21.62] synonym: "subtilisin GX" RELATED [EC:3.4.21.62] synonym: "subtilisin J" RELATED [EC:3.4.21.62] synonym: "subtilisin S41" RELATED [EC:3.4.21.62] synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] xref: EC:3.4.21.62 xref: MetaCyc:3.4.21.62-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004293 name: obsolete tissue kallikrein activity namespace: molecular_function alt_id: GO:0004279 def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.35] synonym: "callicrein" RELATED [EC:3.4.21.35] synonym: "depot-padutin" RELATED [EC:3.4.21.35] synonym: "dilminal D" RELATED [EC:3.4.21.35] synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] synonym: "glumorin" RELATED [EC:3.4.21.35] synonym: "kallidinogenase" BROAD [EC:3.4.21.35] synonym: "kallikrein" RELATED [EC:3.4.21.35] synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] synonym: "kininogenase" BROAD [EC:3.4.21.35] synonym: "kininogenin activity" RELATED [EC:3.4.21.35] synonym: "onokrein P" RELATED [EC:3.4.21.35] synonym: "padreatin" RELATED [EC:3.4.21.35] synonym: "padutin" RELATED [EC:3.4.21.35] synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "tissue kallikrein activity" EXACT [] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] xref: EC:3.4.21.35 xref: MetaCyc:3.4.21.35-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004294 name: obsolete tripeptidyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] comment: This term was made obsolete because it represents a gene product. synonym: "TPP" RELATED [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl-peptidase II activity" EXACT [] xref: EC:3.4.14.10 xref: MetaCyc:3.4.14.10-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0004295 name: obsolete trypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] synonym: "cocoonase activity" EXACT [EC:3.4.21.4] synonym: "parenzyme" RELATED [EC:3.4.21.4] synonym: "parenzymol" RELATED [EC:3.4.21.4] synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "trypsin activity" EXACT [] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] xref: EC:3.4.21.4 xref: MetaCyc:3.4.21.4-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004298 name: threonine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#ENDOPEPTIDASE] synonym: "26S protease" RELATED [EC:3.4.25] synonym: "alkaline protease" RELATED [EC:3.4.25] synonym: "ingensin" RELATED [EC:3.4.25] synonym: "large multicatalytic protease" NARROW [EC:3.4.25] synonym: "lens neutral proteinase" NARROW [EC:3.4.25] synonym: "MCP" RELATED [EC:3.4.25] synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] synonym: "prosome" RELATED [EC:3.4.25] synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] synonym: "threonine endopeptidase activity" EXACT [] synonym: "tricorn protease" NARROW [EC:3.4.25] synonym: "tricorn proteinase" NARROW [EC:3.4.25] xref: EC:3.4.25 is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070003 ! threonine-type peptidase activity [Term] id: GO:0004299 name: obsolete proteasome endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] comment: This term was made obsolete because it mentions a component term in the text string. synonym: "multicatalytic endopeptidase" RELATED [] synonym: "proteasome" RELATED [] synonym: "proteasome endopeptidase activity" EXACT [] synonym: "proteasome endopeptidase complex" RELATED [] is_obsolete: true consider: GO:0004175 consider: GO:0008233 [Term] id: GO:0004300 name: enoyl-CoA hydratase activity namespace: molecular_function alt_id: GO:0016510 def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2-enoyl-CoA + H2O." [EC:4.2.1.17] synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] synonym: "ECH" RELATED [EC:4.2.1.17] synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: reactome:R-HSA-70830 "tiglyl-CoA + H2O <=> alpha-methyl-beta-hydroxybutyryl-CoA" xref: reactome:R-HSA-70870 "methacrylyl-CoA + H2O <=> beta-hydroxyisobutyryl-CoA" xref: reactome:R-HSA-77256 "2-trans-Dodecenoyl-CoA+H2O<=>(S)-3-Hydroxydodecanoyl-CoA" xref: reactome:R-HSA-77277 "trans-Tetradec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxytetradecanoyl-CoA" xref: reactome:R-HSA-77301 "trans-Hexadec-2-enoyl-CoA+H2O<=>(S)-3-Hydroxyhexadecanoyl-CoA" xref: reactome:R-HSA-77314 "Crotonoyl-CoA+H2O<=>(S)-3-Hydroxybutanoyl-CoA" xref: reactome:R-HSA-77325 "trans-Hex-2-enoyl-CoA+H2O<=>(S)-Hydroxyhexanoyl-CoA" xref: reactome:R-HSA-77333 "trans-Oct-2-enoyl-CoA+H2O<=>(S)-Hydroxyoctanoyl-CoA" xref: reactome:R-HSA-77344 "trans-Dec-2-enoyl-CoA+H2O<=>(S)-Hydroxydecanoyl-CoA" xref: RHEA:16105 xref: UM-BBD_enzymeID:e0014 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: goslim_chembl synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: reactome:R-HSA-2161961 "EET(1) is hydrolysed to DHET(1) by EPHX2" xref: reactome:R-HSA-9018862 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(S)-HEPE to 18(S)-RvE1" xref: reactome:R-HSA-9018877 "LTA4H:Zn2+ hydrolyses 5S,6S-epoxy-18(R)-HEPE to 18(R)-RvE1" xref: reactome:R-HSA-9020252 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(R)-HDHA to AT-RvD1 or AT-RvD2" xref: reactome:R-HSA-9020253 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(S)-HDHA to RvD3 or RvD4" xref: reactome:R-HSA-9020257 "LTA4H:Zn2+ hydrolyses 17R(16)-epoxy-DHA to AT-(N)PD1" xref: reactome:R-HSA-9020258 "LTA4H:Zn2+ hydrolyses 7S(8)-epoxy-17(S)-HDHA to RvD1 or RvD2" xref: reactome:R-HSA-9020270 "LTA4H:Zn2+ hydrolyses 4S(5)-epoxy-17(R)-HDHA to AT-RvD3 or AT-RvD4" xref: reactome:R-HSA-9024890 "LTA4H:Zn2+ hydrolyses 16S,17S-epoxy-DHA to (N)PD1" xref: reactome:R-HSA-9024973 "Epoxide hydrolase hydrolyses 13(S),14(S)-epoxy-DHA to MaR1" xref: reactome:R-HSA-9024993 "EPHX2 dimer hydrolyses 13(S),14(S)-epoxy-DHA to MaR2" xref: reactome:R-HSA-9025998 "Epoxide hydrolase hydrolyses 13,14-epoxy-DPAn-3 to MaR1n-3 DPA or MaR2n-3 DPA" xref: reactome:R-HSA-9026000 "Epoxide hydrolase hydrolyses 16(S),17(S)-epoxy-DPAn-3 to PD1n-3DPA or PD2n-3DPA" xref: reactome:R-HSA-9026008 "Epoxide hydrolase hydrolyses 7,8-epoxy-HDPAn-3 to RvD1n-3DPA or RvD2n-3DPA" xref: UM-BBD_enzymeID:e0397 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004303 name: estradiol 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-HSD" RELATED [EC:1.1.1.62] synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] xref: EC:1.1.1.62 xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN xref: reactome:R-HSA-5693390 "HSD17B11 dehydrogenates EST17b to E1" xref: reactome:R-HSA-5696822 "AKR1B15 reduces EST17b to E1" xref: reactome:R-HSA-6810594 "HSD17B14 tetramer oxidises estradiol (E2) to estrone (E1)" xref: reactome:R-HSA-804969 "HSD17B1 hydrogenates E1 to EST17b" xref: reactome:R-HSA-8862137 "HSD17B2 oxidises estradiol (E2) to estrone (E1)" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004304 name: estrone sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrone sulphotransferase activity" EXACT [] synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] xref: EC:2.8.2.4 xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-176664 "estrone + PAPS => estrone 3-sulfate + PAP" xref: RHEA:15973 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004305 name: ethanolamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ethanolamine = ADP + 2 H(+) + phosphoethanolamine." [EC:2.7.1.82, RHEA:13069] synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] xref: EC:2.7.1.82 xref: KEGG:R01468 xref: MetaCyc:ETHANOLAMINE-KINASE-RXN xref: reactome:R-HSA-1483222 "ETA is phosphorylated to PETA by CHK/ETNK" xref: RHEA:13069 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004306 name: ethanolamine-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "ET" RELATED [EC:2.7.7.14] synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] xref: EC:2.7.7.14 xref: MetaCyc:2.7.7.14-RXN xref: reactome:R-HSA-1483190 "PETA and CTP are condensed to CDP-ETA by PCY2" xref: RHEA:24592 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004307 name: ethanolaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "EPT" RELATED [EC:2.7.8.1] synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] xref: EC:2.7.8.1 xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN xref: reactome:R-HSA-1482962 "CDP-ETA and DAG are converted to PE by CEPT1/EPT1" xref: RHEA:14596 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004308 name: exo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "sialidase activity" EXACT [EC:3.2.1.18] xref: EC:3.2.1.18 xref: MetaCyc:3.2.1.18-RXN xref: reactome:R-HSA-1605723 "Neu5Ac is cleaved from GM3 by NEU2 to form a globoside (cytosol)" xref: reactome:R-HSA-1605724 "Neu5Ac is cleaved from GM3 by NEU1 and 4 to form a globoside (lysosomal lumen)" xref: reactome:R-HSA-1605768 "Neu5Ac is cleaved from GM3 by NEU3 to form globoside (plasma membrane)" xref: reactome:R-HSA-168870 "Neuraminidase enzymatic release from sialic acid" xref: reactome:R-HSA-4084994 "NEU3 hydrolyzes Neu5Ac from glycoconjugates" xref: reactome:R-HSA-4084999 "NEU1,4 hydrolyses Neu5Ac from glycoconjugates" xref: reactome:R-HSA-4085029 "NEU2 hydrolyzes Neu5Ac from glycoconjugates" is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0004309 name: exopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] synonym: "exopolypase activity" EXACT [EC:3.6.1.11] synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004310 name: farnesyl-diphosphate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:2.5.1.21-RXN xref: reactome:R-HSA-191402 "Reduction of presqualene diphosphate to form squalene" xref: reactome:R-HSA-191405 "Two FPP molecules dimerize to form presqualene diphosphate" is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0004311 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29, RHEA:17653] comment: The catalyzed reaction forms (free) geranylgeranyl diphosphate. There is no relationship between this activity and protein farnesyltransferase activity, GO:0004660, where the catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: KEGG:R02061 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: RHEA:17653 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004312 name: fatty acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN xref: reactome:R-HSA-75872 "acetyl-CoA + 7 malonyl-CoA + 14 NADHP + 14 H+ => palmitate + 7 CO2 + 14 NADP+ + 8 CoASH + 6 H2O" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0004313 name: [acyl-carrier-protein] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] synonym: "ACAT activity" BROAD [EC:2.3.1.38] synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP S-acetyltransferase activity" EXACT [] synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0004314 name: [acyl-carrier-protein] S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] synonym: "ACP S-malonyltransferase activity" EXACT [] synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "FabD" RELATED [EC:2.3.1.39] synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "MAT" RELATED [EC:2.3.1.39] synonym: "MCAT activity" EXACT [EC:2.3.1.39] xref: EC:2.3.1.39 xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN xref: reactome:R-HSA-8933547 "MCAT transfers Mal from Mal-CoA to NDUFAB1" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016419 ! S-malonyltransferase activity [Term] id: GO:0004315 name: 3-oxoacyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] synonym: "3-oxoacyl-ACP synthase activity" EXACT [] synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "FabB" RELATED [EC:2.3.1.41] synonym: "FabF1" RELATED [EC:2.3.1.41] synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "KAS I activity" NARROW [EC:2.3.1.41] synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0004316 name: 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "3-oxoacyl-ACP reductase activity" EXACT [] synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] xref: EC:1.1.1.100 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN xref: reactome:R-HSA-8862152 "2xHSD17B8:2xCBR4 reduces 3OA-ACP to 3HA-ACP" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004317 name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] xref: EC:4.2.1.61 xref: KEGG:R04462 xref: MetaCyc:4.2.1.61-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0004318 name: enoyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] xref: EC:1.3.1.9 xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004319 name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] xref: EC:1.3.1.10 xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004320 name: oleoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "oleoyl-ACP hydrolase activity" EXACT [] synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0004321 name: fatty-acyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] synonym: "fatty acyl CoA synthase activity" EXACT [GOC:curators] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0004322 name: ferroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferroxidase I" RELATED [EC:1.16.3.1] synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] xref: EC:1.16.3.1 xref: MetaCyc:RXN0-1483 xref: reactome:R-HSA-1562603 "BfrB stores iron" xref: reactome:R-HSA-1562604 "BfrA stores iron" xref: reactome:R-HSA-1562626 "Ferritin Complex oxidises 4Fe2+ to Fe(3+)O(OH)" xref: reactome:R-HSA-5691107 "FTMT 24mer oxidises 4Fe2+ to 4Fe(3+)O(OH)" xref: reactome:R-HSA-917891 "SLC40A1:CP:6Cu2+ oxidises Fe2+ to Fe3+" xref: reactome:R-HSA-917933 "SLC40A1:HEPH:6Cu2+ oxidises 4Fe2+ to 4Fe3+" xref: RHEA:11148 is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor [Term] id: GO:0004323 name: obsolete multicopper ferroxidase iron transport mediator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "multicopper ferroxidase iron transport mediator activity" EXACT [] is_obsolete: true consider: GO:0004322 consider: GO:0005381 [Term] id: GO:0004324 name: ferredoxin-NADP+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-NADP reductase activity" EXACT [] synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: MetaCyc:1.18.1.2-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0004325 name: ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme = Fe(2+) + protoporphyrin IX." [EC:4.99.1.1, RHEA:22584] synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] synonym: "heme synthase activity" EXACT [EC:4.99.1.1] synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] xref: EC:4.99.1.1 xref: KEGG:R00310 xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN xref: reactome:R-HSA-189465 "FECH binds Fe2+ to PRIN9 to form heme" xref: RHEA:22584 is_a: GO:0016829 ! lyase activity [Term] id: GO:0004326 name: tetrahydrofolylpolyglutamate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamate synthase activity" EXACT [] synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "FPGS activity" EXACT [EC:6.3.2.17] synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] xref: EC:6.3.2.17 xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN xref: reactome:R-HSA-197958 "Conversion of cytosolic THF to THF-polyglutamate" xref: reactome:R-HSA-200681 "Conversion of cytosolic 5-methyltetrahydrofolate (5-methylTHF) to 5-methylTHF-polyglutamate" xref: reactome:R-HSA-200682 "Conversion of mitochondrial THF to THF-polyglutamate" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004327 name: obsolete formaldehyde dehydrogenase (glutathione) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. synonym: "formaldehyde dehydrogenase (glutathione) activity" EXACT [] is_obsolete: true consider: GO:0051903 consider: GO:0051907 [Term] id: GO:0004328 name: formamidase activity namespace: molecular_function alt_id: GO:0034566 def: "Catalysis of the reaction: formamide + H(2)O = formate + NH(4)(+)." [EC:3.5.1.49, RHEA:21948] synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] synonym: "formamide hydrolase activity" EXACT [] xref: EC:3.5.1.49 xref: KEGG:R00524 xref: MetaCyc:FORMAMIDASE-RXN xref: RHEA:21948 xref: UM-BBD_reactionID:r0873 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004329 name: formate-tetrahydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw] synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] xref: EC:6.3.4.3 xref: MetaCyc:FORMATETHFLIG-RXN xref: reactome:R-HSA-200711 "THF polyglutamate + formate + ATP => 10-formylTHF polyglutamate + ADP + orthophosphate" xref: reactome:R-HSA-5696839 "MTHFD1L ligates HCOOH to THF to form 10-formyl-THF" xref: reactome:R-HSA-6801456 "MTHFD1L transforms 10-formyl-THF to HCOOH and THF" xref: RHEA:20221 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004331 name: fructose-2,6-bisphosphate 2-phosphatase activity namespace: molecular_function alt_id: GO:0004330 def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose-6-phosphate + phosphate." [EC:3.1.3.46] synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] xref: EC:3.1.3.46 xref: MetaCyc:3.1.3.46-RXN xref: reactome:R-HSA-5628905 "TIGAR converts D-fructose-2,6-bisphosphate to D-fructose 6-phosphate" xref: reactome:R-HSA-70262 "Fructose 2,6-bisphosphate is hydrolyzed to form fructose-6-phosphate and orthophosphate" xref: RHEA:17289 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0004332 name: fructose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde-3-phosphate." [EC:4.1.2.13] synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "aldolase activity" BROAD [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "SMALDO" RELATED [EC:4.1.2.13] synonym: "zymohexase activity" EXACT [EC:4.1.2.13] xref: EC:4.1.2.13 xref: MetaCyc:F16ALDOLASE-RXN xref: reactome:R-HSA-71495 "dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate <=> D-fructose 1,6-bisphosphate" xref: reactome:R-HSA-71496 "D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate" xref: RHEA:14729 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004333 name: fumarate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate = fumarate + H(2)O." [EC:4.2.1.2, RHEA:12460] synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] synonym: "fumarase activity" EXACT [EC:4.2.1.2] synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] xref: EC:4.2.1.2 xref: KEGG:R01082 xref: MetaCyc:FUMHYDR-RXN xref: reactome:R-HSA-451033 "(S)-Malate <=> Fumarate + H2O" xref: reactome:R-HSA-70982 "Fumarate + H2O <=> (S)-Malate" xref: RHEA:12460 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004334 name: fumarylacetoacetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-fumarylacetoacetate + H(2)O = acetoacetate + fumarate + H(+)." [EC:3.7.1.2, RHEA:10244] synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] xref: EC:3.7.1.2 xref: KEGG:R01364 xref: MetaCyc:FUMARYLACETOACETASE-RXN xref: reactome:R-HSA-71181 "fumarylacetoacetate => fumarate + acetoacetate" xref: RHEA:10244 xref: UM-BBD_reactionID:r0107 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0004335 name: galactokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + ATP = alpha-D-galactose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.6, RHEA:13553] synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] xref: EC:2.7.1.6 xref: KEGG:R01092 xref: MetaCyc:GALACTOKIN-RXN xref: reactome:R-HSA-70355 "GALK1 phosphorylates Gal to Gal1P" xref: RHEA:13553 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004336 name: galactosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galcerase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] xref: EC:3.2.1.46 xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN xref: reactome:R-HSA-1606564 "Galactocerebrosidase cleaves the galactosyl bond of galactocerebroside to form ceramide" xref: RHEA:14297 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004337 name: geranyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = 2-trans,6-trans-farnesyl diphosphate + diphosphate." [EC:2.5.1.10, RHEA:19361] comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] synonym: "farnesyl-diphosphate synthase activity" EXACT [] synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] xref: EC:2.5.1.10 xref: KEGG:R02003 xref: MetaCyc:FPPSYN-RXN xref: reactome:R-HSA-191303 "Another isopentenyl pyrophosphate is added to geranyl pyrophosphate" xref: reactome:R-HSA-8870469 "RGGT geranylgeranylates RAB proteins" xref: RHEA:19361 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004338 name: glucan exo-1,3-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of (1->3)-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] synonym: "1,3-beta-glucan glucohydrolase activity" BROAD [EC:3.2.1.58] synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] synonym: "glucan 1,3-beta-glucosidase activity" BROAD [GOC:mah] xref: EC:3.2.1.58 xref: MetaCyc:3.2.1.58-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0004339 name: glucan 1,4-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal (1->4)-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0090599', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0090599 alpha-D-glucose is released. synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] synonym: "glucoamylase activity" EXACT [] synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] xref: EC:3.2.1.3 xref: MetaCyc:3.2.1.3-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004340 name: glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose-6-phosphate." [EC:2.7.1.2] synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] xref: EC:2.7.1.2 xref: MetaCyc:GLUCOKIN-RXN xref: reactome:R-HSA-70420 "HK1,2,3,GCK phosphorylate Glc to form G6P" xref: RHEA:17825 is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0004341 name: gluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] synonym: "lactonase activity" BROAD [EC:3.1.1.17] xref: EC:3.1.1.17 xref: MetaCyc:GLUCONOLACT-RXN xref: RHEA:10440 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004342 name: glucosamine-6-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H(2)O = beta-D-fructose 6-phosphate + NH(4)(+)." [EC:3.5.99.6, RHEA:12172] comment: Note that this function was formerly EC:5.3.1.10. synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] xref: EC:3.5.99.6 xref: KEGG:R00765 xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN xref: reactome:R-HSA-6799604 "GNPDA1,2 hexamers deaminate GlcN6P to Fru(6)P" xref: RHEA:12172 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004343 name: glucosamine 6-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + acetyl-CoA = N-acetyl-D-glucosamine 6-phosphate + CoA + H(+)." [EC:2.3.1.4, RHEA:10292] synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] xref: EC:2.3.1.4 xref: KEGG:R02058 xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN xref: reactome:R-HSA-449734 "Acetylation of glucosamine 6-phosphate to GlcNAc6P" xref: RHEA:10292 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004344 name: glucose dehydrogenase activity namespace: molecular_function alt_id: GO:0008708 def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [PMID:22027299] synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] xref: EC:1.1.99.10 xref: KEGG:R00305 xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:24540 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004345 name: glucose-6-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] synonym: "6-phosphoglucose dehydrogenas" RELATED [] synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] synonym: "G6PD activity" EXACT [EC:1.1.1.49] synonym: "G6PDH" EXACT [] synonym: "GDH" RELATED [] synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] synonym: "Zwischenferment" RELATED [] synonym: "zwischenferment" RELATED [EC:1.1.1.49] xref: EC:1.1.1.49 xref: MetaCyc:GLU6PDEHYDROG-RXN xref: reactome:R-HSA-70377 "alpha-D-glucose 6-phosphate + NADP+ => D-glucono-1,5-lactone 6-phosphate + NADPH + H+" xref: RHEA:15841 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004346 name: glucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucopyranose 6-phosphate + H2O = D-glucose + phosphate. D-glucopyranose is also known as D-glucose 6-phosphate." [EC:3.1.3.9, RHEA:16689] synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] xref: EC:3.1.3.9 xref: KEGG:R00303 xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN xref: reactome:R-HSA-3262512 "G6PC3 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (ubiquitous)" xref: reactome:R-HSA-3266566 "G6PC2 hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (islet)" xref: reactome:R-HSA-71825 "G6PC hydrolyzes glucose 6-phosphate to form glucose and orthophosphate (liver)" xref: RHEA:16689 is_a: GO:0050309 ! sugar-terminal-phosphatase activity [Term] id: GO:0004347 name: glucose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] xref: EC:5.3.1.9 xref: MetaCyc:PGLUCISOM-RXN xref: reactome:R-HSA-70471 "alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate" xref: reactome:R-HSA-70475 "D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate" xref: RHEA:11816 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004348 name: glucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] xref: EC:3.2.1.45 xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN xref: reactome:R-HSA-1605591 "Glucosylceramidase cleaves the glucosidic bond of glucocerebroside to form ceramide" xref: reactome:R-HSA-1861788 "Glucosylceramidase 2 cleaves the glucosidic bond of glucocerebroside to form ceramide (plasma membrane)" xref: reactome:R-HSA-1861789 "Glucosylceramidase 3 cleaves the glucosidic bond of glucocerebroside to form ceramide (cytosol)" xref: RHEA:13269 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004349 name: glutamate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP = L-glutamyl 5-phosphate + ADP + H(+)." [EC:2.7.2.11, RHEA:14877] synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] xref: EC:2.7.2.11 xref: KEGG:R00239 xref: MetaCyc:GLUTKIN-RXN xref: RHEA:14877 is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004350 name: glutamate-5-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0001513 def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + NADP(+) + phosphate = L-glutamyl 5-phosphate + H(+) + NADPH." [EC:1.2.1.41, RHEA:19541] synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-phosphate reductase activity" EXACT [] synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamylphosphate reductase activity" EXACT [] synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] xref: EC:1.2.1.41 xref: KEGG:R03313 xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN xref: RHEA:19541 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004351 name: glutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: MetaCyc:GLUTDECARBOX-RXN xref: reactome:R-HSA-888572 "Synthesis of GABA by GAD1" xref: reactome:R-HSA-888577 "Synthesis of GABA by GAD2" xref: RHEA:17785 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004352 name: glutamate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN xref: RHEA:15133 is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004353 name: glutamate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] xref: EC:1.4.1.3 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN xref: MetaCyc:GLUTAMATE-SYN2-PWY xref: reactome:R-HSA-70589 "alpha-ketoglutarate + NH4+ + NAD(P)H + H+ <=> glutamate + NAD(P)+ [GLUD1]" xref: reactome:R-HSA-70600 "glutamate + NAD(P)+ => alpha-ketoglutarate + NH4+ + NAD(P)H + H+ [GLUD1]" is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004354 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY xref: RHEA:11612 is_a: GO:0004353 ! glutamate dehydrogenase [NAD(P)+] activity [Term] id: GO:0004355 name: glutamate synthase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NADP(+) = 2-oxoglutarate + L-glutamine + H(+) + NADPH. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + NADP+ + H2O = NH3 + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13, RHEA:15501] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] synonym: "GOGAT activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] synonym: "NADPH GOGAT" EXACT [] synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] xref: EC:1.4.1.13 xref: KEGG:R00114 xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTAMATESYN-RXN xref: MetaCyc:GLUTSYN-PWY xref: RHEA:15501 is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor [Term] id: GO:0004356 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NH(3) = L-glutamine + ADP + 2 H(+) + phosphate." [EC:6.3.1.2, RHEA:16169] synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: KEGG:R00253 xref: MetaCyc:GLUTAMINESYN-RXN xref: reactome:R-HSA-70606 "glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]" xref: RHEA:16169 is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004357 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H(+) + phosphate." [EC:6.3.2.2, RHEA:13285] synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: KEGG:R00894 xref: MetaCyc:GLUTCYSLIG-RXN xref: reactome:R-HSA-174367 "GCL ligates L-Glu to L-Cys" xref: RHEA:13285 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004358 name: glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-acetyl-L-ornithine + L-glutamate = N-acetyl-L-glutamate + L-ornithine." [EC:2.3.1.35, RHEA:15349] synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] xref: EC:2.3.1.35 xref: KEGG:R02282 xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN xref: RHEA:15349 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004359 name: glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] synonym: "glutaminase I" RELATED [EC:3.5.1.2] synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] xref: EC:3.5.1.2 xref: MetaCyc:GLUTAMIN-RXN xref: reactome:R-HSA-70609 "glutamine + H2O => glutamate + NH4+ [GLS]" xref: RHEA:15889 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004360 name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate." [EC:2.6.1.16, RHEA:13237] synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] xref: EC:2.6.1.16 xref: KEGG:R00768 xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN xref: reactome:R-HSA-449715 "GFPT1,2 transfer an amino group from L-Gln to F6P to form GlcN6P" xref: RHEA:13237 is_a: GO:0070548 ! L-glutamine aminotransferase activity [Term] id: GO:0004361 name: glutaryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7] synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] xref: EC:1.3.99.7 xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN xref: reactome:R-HSA-71046 "glutaryl-CoA + FAD => crotonyl-CoA + FADH2 + CO2" xref: RHEA:13389 xref: UM-BBD_reactionID:r0198 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004362 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732] comment: Note that this function was formerly EC:1.6.4.2. synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: reactome:R-HSA-3323079 "GSR catalyzes glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" xref: reactome:R-HSA-71682 "glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+" xref: RHEA:11740 is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004363 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate." [EC:6.3.2.3, RHEA:13557] synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: KEGG:R00497 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: reactome:R-HSA-174394 "GSS:Mg2+ dimer synthesizes GSH" xref: RHEA:13557 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004364 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: MetaCyc:GSHTRAN-RXN xref: reactome:R-HSA-176054 "GST dimers conjugate GSH with cytosolic substrates" xref: reactome:R-HSA-176059 "GST trimers transfer GS from GSH to luminal substrates" xref: reactome:R-HSA-3301943 "GSTK1 dimer transfers GS from GSH to CDNB" xref: reactome:R-HSA-5423653 "MGST trimers transfer GS from GSH to AFXBO and AFNBO" xref: reactome:R-HSA-9026777 "GSTM4 dimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" xref: reactome:R-HSA-9026780 "LTC4S trimer transfers GSH to 13(S),14(S)-epoxy-DHA to form MCTR1" xref: reactome:R-HSA-9026901 "GGT transfers GSH to 16S,17S-epoxy-DHA to form PCTR1" xref: reactome:R-HSA-9026911 "LTC4S trimer transfers GSH to 7S(8)-epoxy-17(S)-HDHA to form RCTR1" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004365 name: glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] synonym: "GAPDH activity" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] xref: EC:1.2.1.12 xref: MetaCyc:GAPOXNPHOSPHN-RXN xref: reactome:R-HSA-70449 "D-glyceraldehyde 3-phosphate + orthophosphate + NAD+ <=> 1,3-bisphospho-D-glycerate + NADH + H+" xref: reactome:R-HSA-70482 "1,3-bisphospho-D-glycerate + NADH + H+ <=> D-glyceraldehyde 3-phosphate + Orthophosphate + NAD+" xref: RHEA:10300 is_a: GO:0043891 ! glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity [Term] id: GO:0004366 name: glycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] xref: EC:2.3.1.15 xref: MetaCyc:RXN-1381 xref: reactome:R-HSA-1482695 "G3P is acylated to 1-acyl LPA by GPAM/GPAT2 (OM)" xref: reactome:R-HSA-549112 "G3P is acylated to 1-acyl LPA by AGPAT6" xref: reactome:R-HSA-75886 "glycerol 3-phosphate + acyl-CoA => 1-acylglycerol 3-phosphate + CoASH [mitochondrial membrane-associated]" xref: RHEA:15325 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004367 name: glycerol-3-phosphate dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8, EC:1.1.1.94] synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "hydroglycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-alpha-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerol phosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "L-glycerophosphate dehydrogenase activity" BROAD [EC:1.1.1.8] synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] xref: EC:1.1.1.8 xref: EC:1.1.1.94 xref: KEGG:R00842 xref: MetaCyc:1.1.1.8-RXN xref: reactome:R-HSA-75889 "DHAP is converted to G3P by GPD1/GPD1L" xref: RHEA:11092 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004368 name: glycerol-3-phosphate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + a quinone = glycerone phosphate + a quinol." [EC:1.1.5.3] comment: Note that enzymes classified as EC:1.1.5.3 have several activities. They should be annotated with the terms GO:0004368, GO:0052590 and GO:0052591. synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.5.3] synonym: "glycerol-3-phosphate CoQ reductase" EXACT [EC:1.1.5.3] synonym: "glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.5.3] synonym: "sn-glycerol-3-phosphate:quinone oxidoreductase activity" EXACT systematic_synonym [EC:1.1.5.3] xref: EC:1.1.5.3 xref: MetaCyc:RXN-9927 xref: MetaCyc:RXN0-5260 xref: reactome:R-HSA-188467 "Gly-3-P+FAD->DHAP+FADH2 (catalyzed by mitochondrial Gly-Phos dehydrogenase)" xref: RHEA:18977 is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004369 name: glycerol-3-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O(2) = glycerone phosphate + H(2)O(2)." [EC:1.1.3.21, RHEA:18369] synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] xref: EC:1.1.3.21 xref: KEGG:R00846 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN xref: RHEA:18369 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0004370 name: glycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerol = sn-glycerol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.30, RHEA:21644] synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "GK" RELATED [EC:2.7.1.30] synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] xref: EC:2.7.1.30 xref: KEGG:R00847 xref: MetaCyc:GLYCEROL-KIN-RXN xref: reactome:R-HSA-75887 "Conversion of Glycerol to Glycerol-3-phosphate" xref: RHEA:21644 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004371 name: glycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H(+)." [EC:2.7.1.29, RHEA:15773] synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] xref: EC:2.7.1.29 xref: KEGG:R01011 xref: MetaCyc:GLYCERONE-KINASE-RXN xref: RHEA:15773 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004372 name: glycine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] xref: EC:2.1.2.1 xref: MetaCyc:GLYOHMETRANS-RXN xref: reactome:R-HSA-200651 "5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine" xref: reactome:R-HSA-200735 "Tetrahydrofolate polyglutamate (THF polyglutamate) + serine <=> 5,10-methyleneTHF polyglutamate + glycine" xref: reactome:R-HSA-5694137 "SHMT2 tetramer transfers CH2OH group from 5,10MTHF to glycine" xref: reactome:R-HSA-71249 "SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly" xref: RHEA:15481 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004373 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] xref: EC:2.4.1.11 xref: MetaCyc:2.4.1.11-RXN xref: reactome:R-HSA-3322001 "GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" xref: reactome:R-HSA-3322009 "GYS2 catalyzes the polyglucosylation of oligoGlc-GYG2" xref: reactome:R-HSA-3322041 "Phosphorylated GYS1 catalyzes the polyglucosylation of oligoGlc-GYG1" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004374 name: obsolete glycine cleavage system namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] comment: This term was made obsolete because it represents a process rather than a function. synonym: "glycine cleavage system" EXACT [] synonym: "glycine synthase" BROAD [] is_obsolete: true replaced_by: GO:0019464 [Term] id: GO:0004375 name: glycine dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: MetaCyc:GCVP-RXN xref: reactome:R-HSA-5693967 "GLDC dimer:2xPXLP decarboxylates Gly" is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] id: GO:0004376 name: glycolipid mannosyltransferase activity namespace: molecular_function alt_id: GO:0004580 def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] synonym: "glycolipid mannosyl transferase activity" EXACT [] xref: reactome:R-HSA-162821 "mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" xref: reactome:R-HSA-162873 "(ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate D-mannose -> mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + dolichol phosphate" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004377 name: GDP-Man:Man3GlcNAc2-PP-Dol alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP-alpha-D-mannose = an alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + 2 GDP + 2 H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->2)-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] synonym: "GDP-D-mannose:D-Man-alpha-(1->3)-[D-Man-alpha-(1->6)]-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol alpha-1,2-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "glycolipid 2-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] xref: EC:2.4.1.131 xref: MetaCyc:2.4.1.131-RXN xref: RHEA:29523 is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004378 name: GDP-Man:Man1GlcNAc2-PP-Dol alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP-alpha-D-mannose = alpha-D-Man-(1->3)-beta-D-Man-(1->4)-beta-D-GlcNAc-(1->4)-D-GlcNAc-diphosphodolichol + GDP + H+. This reaction is the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->3)-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] synonym: "GDP-D-mannose:D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol 3-alpha-mannosyltransferase activity" EXACT systematic_synonym [EC:2.4.1.132] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "glycolipid 3-alpha-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] xref: EC:2.4.1.132 xref: MetaCyc:2.4.1.132-RXN xref: RHEA:29515 is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004379 name: glycylpeptide N-tetradecanoyltransferase activity namespace: molecular_function alt_id: GO:0019106 def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] synonym: "N-myristoyltransferase activity" EXACT [] synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] xref: EC:2.3.1.97 xref: MetaCyc:2.3.1.97-RXN xref: reactome:R-HSA-184392 "N-myristoylation of GAG polyprotein by NMT2" xref: reactome:R-HSA-2534087 "NMT1/2 transfer MYS to GNAT1" is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0004380 name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] synonym: "A transferase activity" RELATED [EC:2.4.1.40] synonym: "A-transferase activity" EXACT [EC:2.4.1.40] synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] xref: EC:2.4.1.40 xref: MetaCyc:2.4.1.40-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0004381 name: fucosylgalactoside 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "B transferase activity" RELATED [EC:2.4.1.37] synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1,2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1,2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] xref: EC:2.4.1.37 xref: MetaCyc:2.4.1.37-RXN xref: RHEA:14349 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004382 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN xref: RHEA:22156 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004383 name: guanylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] synonym: "guanylyl cyclase activity" EXACT [] synonym: "receptor guanylate cyclase activity" NARROW [] xref: EC:4.6.1.2 xref: MetaCyc:GUANYLCYC-RXN xref: reactome:R-HSA-392152 "Soluble guanylate cyclase converts GTP to cGMP" xref: reactome:R-HSA-74885 "GUCYs converts GTP to cGMP" xref: RHEA:13665 is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004384 name: obsolete membrane-associated guanylate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "MAGUK" EXACT [] synonym: "membrane-associated guanylate kinase" EXACT [] is_obsolete: true consider: GO:0004385 consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0050839 [Term] id: GO:0004385 name: guanylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] synonym: "membrane-associated guanylate kinase" NARROW [] xref: EC:2.7.4.8 xref: MetaCyc:GUANYL-KIN-RXN xref: reactome:R-HSA-110133 "(d)GDP + ADP <=> (d)GMP + ATP (GUK1)" xref: reactome:R-HSA-73788 "(d)GMP + ATP <=> (d)GDP + ADP (GUK1)" xref: RHEA:20780 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate, to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast xref: reactome:R-HSA-167097 "HIV Promoter Opening: First Transition" xref: reactome:R-HSA-169461 "MCM8 mediated fork unwinding" xref: reactome:R-HSA-169468 "MCM2-7 mediated fork unwinding" xref: reactome:R-HSA-5690996 "ERCC2 and ERCC3 DNA helicases form an open bubble structure in damaged DNA" xref: reactome:R-HSA-75949 "RNA Polymerase II Promoter Opening: First Transition" xref: reactome:R-HSA-9613490 "Unwinding of DNA for the nascent HIV-1 transcript: Second Transition" xref: reactome:R-HSA-9613494 "Unwinding of DNA for the Nascent Transcript: Second Transition" xref: reactome:R-HSA-9613497 "Unwinding DNA for the nascent transcript" xref: reactome:R-HSA-9613498 "Unwinding of DNA for the nascent HIV-1 transcript" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0004392 name: heme oxygenase (decyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] synonym: "haem oxidase activity" EXACT [EC:1.14.99.3] synonym: "haem oxygenase (decyclizing) activity" EXACT [] synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme oxidase activity" EXACT [EC:1.14.99.3] synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3] synonym: "ORP33 proteins" RELATED [EC:1.14.99.3] xref: EC:1.14.99.3 xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN xref: reactome:R-HSA-189398 "HMOX1,2 cleave heme" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004394 name: heparan sulfate 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] synonym: "heparin 2-sulfotransferase activity" RELATED [] synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] xref: EC:2.8.2 xref: reactome:R-HSA-2076508 "HS2ST1 sulfates IdoA at C2 in heparan sulfate" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0004395 name: hexaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] xref: EC:2.1.1.114 xref: MetaCyc:2.1.1.114-RXN xref: RHEA:14121 is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity [Term] id: GO:0004396 name: hexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] synonym: "hexokinase D" RELATED [EC:2.7.1.1] synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] xref: EC:2.7.1.1 xref: MetaCyc:HEXOKINASE-RXN xref: RHEA:22740 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004397 name: histidine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] synonym: "histidase activity" RELATED [GOC:hjd] synonym: "histidinase activity" RELATED [GOC:hjd] synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] xref: EC:4.3.1.3 xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN xref: reactome:R-HSA-70899 "histidine => urocanate + NH4+" xref: RHEA:21232 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004398 name: histidine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] xref: EC:4.1.1.22 xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN xref: reactome:R-HSA-977301 "Histidine is decarboxylated to histamine" xref: RHEA:20840 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004399 name: histidinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] xref: EC:1.1.1.23 xref: MetaCyc:HISTALDEHYD-RXN xref: MetaCyc:HISTOLDEHYD-RXN xref: RHEA:20641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004400 name: histidinol-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "histidinol-phosphate aminotransferase activity" EXACT [] synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] xref: EC:2.6.1.9 xref: MetaCyc:HISTAMINOTRANS-RXN xref: RHEA:23744 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004401 name: histidinol-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol phosphate + H(2)O = L-histidinol + phosphate." [EC:3.1.3.15, RHEA:14465] synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "HPpase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] xref: EC:3.1.3.15 xref: KEGG:R03013 xref: MetaCyc:HISTIDPHOS-RXN xref: RHEA:14465 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004402 name: histone acetyltransferase activity namespace: molecular_function alt_id: GO:0004403 alt_id: GO:0004404 alt_id: GO:0004405 alt_id: GO:0004406 alt_id: GO:0043166 alt_id: GO:0046971 def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] synonym: "H2A/H2B histone acetyltransferase activity" NARROW [] synonym: "H3/H4 histone acetyltransferase activity" NARROW [] synonym: "H4/H2 histone acetyltransferase activity" NARROW [] synonym: "H4/H2A acetyltransferase activity" NARROW [] synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] synonym: "histone acetylase activity" EXACT [] synonym: "histone lysine acetyltransferase activity" EXACT [] synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48] xref: EC:2.3.1.48 xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-3301237 "KAT2 complexes acetylate histone H3" xref: reactome:R-HSA-3301345 "Elongator complex acetylates replicative histone H3, H4" xref: reactome:R-HSA-3318413 "KAT7-containing ING4/5 complexes acetylate Me3K-histone H3" xref: reactome:R-HSA-3318415 "ATF2 acetylates histone H2B, H4" xref: reactome:R-HSA-3318486 "KAT6A, KAT6B-containing ING5 complexes acetylate replicative histone H3" xref: reactome:R-HSA-3321805 "NSL acetylates histone H4" xref: reactome:R-HSA-3321883 "MSL acetylates histone H4" xref: reactome:R-HSA-3321975 "NuA4 complex acetylates histone H2A, HIST1H4" xref: reactome:R-HSA-3451147 "KAT5 HAT complex acetylates TCF4 gene at histone H4" xref: reactome:R-HSA-3662318 "Type B histone acetlytransferase complex acetylates histone H4" xref: reactome:R-HSA-3662335 "EP300 acetylates histone H2A, H2B, H3, H4" xref: reactome:R-HSA-3697008 "CREBBP acetylates histone H2B, H3, H4" xref: reactome:R-HSA-3697920 "CLOCK acetylates lysine-10 of histone H3, H4" xref: reactome:R-HSA-5144542 "CLOCK acetylates lysine-15 of histone H3, H4" xref: reactome:R-HSA-5250938 "B-WICH:histone acetyltransferase acetylates histone H3 at lysine-9" is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity [Term] id: GO:0004407 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.98, PMID:9893272] xref: EC:3.5.1.98 xref: MetaCyc:3.5.1.98-RXN xref: reactome:R-HSA-2545203 "Deacetylation of cleaved cohesin" xref: reactome:R-HSA-2545253 "Deacetylation of cohesin" xref: reactome:R-HSA-3769447 "HDAC1/2 containing-complexes deacetylate histones" xref: reactome:R-HSA-3777129 "HDAC3 containing complexes deacetylate histone" xref: reactome:R-HSA-3782637 "HDAC8 deacetylates histones" xref: reactome:R-HSA-3782655 "HDAC10 deacetylates histone" xref: reactome:R-HSA-427514 "eNoSC deacetylates histone H3" xref: reactome:R-HSA-433672 "NoRC:HDAC:DNMT deacetylates histone H4 and methylates histone H3" xref: reactome:R-HSA-6805650 "MTA2-NuRD complex deacetylates TP53" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0004408 name: holocytochrome-c synthase activity namespace: molecular_function def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004409 name: homoaconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-homoisocitrate = cis-homoaconitate + H(2)O." [EC:4.2.1.36, RHEA:15485] synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "HACN activity" EXACT [EC:4.2.1.36] synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "Lys4" RELATED [EC:4.2.1.36] synonym: "LysF" RELATED [EC:4.2.1.36] xref: EC:4.2.1.36 xref: KEGG:R04371 xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN xref: RHEA:15485 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004410 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + acetyl-CoA + H(2)O = CoA + H(+) + homocitrate." [EC:2.3.3.14, RHEA:12929] comment: Note that this function was formerly EC:4.1.3.21. synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: KEGG:R00271 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN xref: RHEA:12929 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004411 name: homogentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + O(2) = 4-maleylacetoacetate + H(+)." [EC:1.13.11.5, RHEA:15449] synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] xref: EC:1.13.11.5 xref: KEGG:R02519 xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN xref: reactome:R-HSA-71164 "homogentisate + O2 => maleylacetoacetate" xref: RHEA:15449 xref: UM-BBD_reactionID:r0105 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004412 name: homoserine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] xref: EC:1.1.1.3 xref: MetaCyc:HOMOSERDEHYDROG-RXN xref: RHEA:15761 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004413 name: homoserine kinase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H(+)." [EC:2.7.1.39, RHEA:13985] synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] synonym: "HSK" RELATED [EC:2.7.1.39] xref: EC:2.7.1.39 xref: KEGG:R01771 xref: MetaCyc:HOMOSERKIN-RXN xref: RHEA:13985 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004414 name: homoserine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + acetyl-CoA = O-acetyl-L-homoserine + CoA." [EC:2.3.1.31, RHEA:13701] synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] xref: EC:2.3.1.31 xref: KEGG:R01776 xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN xref: RHEA:13701 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004415 name: hyalurononglucosaminidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4) linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] synonym: "hyaluronoglucosaminidase activity" EXACT [] synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] xref: EC:3.2.1.35 xref: MetaCyc:3.2.1.35-RXN xref: reactome:R-HSA-1793209 "HYAL1 hydrolyses Chondroitin chains" xref: reactome:R-HSA-2160874 "HYAL1 hydrolyses (HA)50" xref: reactome:R-HSA-2160892 "Hyaluronidase 2 (HYAL2) hydrolyses HA into 20kDa fragments" xref: reactome:R-HSA-5693356 "CEMIP hydrolyses HA" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004416 name: hydroxyacylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] xref: EC:3.1.2.6 xref: MetaCyc:GLYOXII-RXN xref: reactome:R-HSA-6783221 "HAGH hydrolyses (R)-S-LGSH to GSH and LACT" xref: RHEA:25245 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004417 name: hydroxyethylthiazole kinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-(2-hydroxyethyl)-4-methylthiazole + ATP = 4-methyl-5-(2-phosphoethyl)-thiazole + ADP + 2 H(+)." [EC:2.7.1.50, RHEA:24212] synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] xref: EC:2.7.1.50 xref: KEGG:R04448 xref: MetaCyc:THIAZOLSYN3-RXN xref: RHEA:24212 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004418 name: hydroxymethylbilane synthase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 4 porphobilinogen = hydroxymethylbilane + 4 NH(4)(+)." [EC:2.5.1.61, RHEA:13185] comment: Note that this function was formerly EC:4.3.1.8. synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] xref: EC:2.5.1.61 xref: KEGG:R00084 xref: MetaCyc:OHMETHYLBILANESYN-RXN xref: reactome:R-HSA-189406 "4 PBGs bind to form HMB" xref: RHEA:13185 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004419 name: hydroxymethylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetoacetate + acetyl-CoA." [EC:4.1.3.4, RHEA:24404] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] xref: EC:4.1.3.4 xref: KEGG:R01360 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN xref: reactome:R-HSA-6788597 "HMGCLL1:Mg2+ cleaves bHMG-CoA to Ac-CoA and ACA" xref: reactome:R-HSA-74180 "HMG CoA => acetoacetic acid + acetyl CoA" xref: RHEA:24404 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004420 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP(+) = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 H(+) + 2 NADPH." [EC:1.1.1.34, RHEA:15989] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: KEGG:R02082 xref: MetaCyc:1.1.1.34-RXN xref: reactome:R-HSA-191352 "Reduction of HMG-CoA produces mevalonate" xref: RHEA:15989 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004421 name: hydroxymethylglutaryl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetyl-CoA + acetyl-CoA + H(2)O = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA + H(+)." [EC:2.3.3.10, RHEA:10188] comment: Note that this function was formerly EC:4.1.3.5. synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] xref: EC:2.3.3.10 xref: KEGG:R01978 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN xref: reactome:R-HSA-191323 "HMGCS1 condenses Ac-CoA and ACA-CoA to form bHMG-CoA" xref: reactome:R-HSA-73918 "acetoacetyl-CoA+acetyl-CoA => HMG-CoA + CoASH" xref: RHEA:10188 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004422 name: hypoxanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] synonym: "6-hydroxypurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] synonym: "HPRT" RELATED [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" BROAD [EC:2.4.2.8] synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" RELATED [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" BROAD [EC:2.4.2.8] xref: EC:2.4.2.8 xref: KEGG:R01132 xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN xref: reactome:R-HSA-74215 "guanine or hypoxanthine + PRPP => GMP or IMP + PPi (HPRT1)" xref: RHEA:17973 is_a: GO:0106130 ! purine phosphoribosyltransferase activity [Term] id: GO:0004423 name: iduronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulphatase activity" EXACT [] synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] xref: EC:3.1.6.13 xref: MetaCyc:3.1.6.13-RXN xref: reactome:R-HSA-1678650 "IDS hydrolyses Heparan sulfate chain(5)" xref: reactome:R-HSA-1793182 "IDS hydrolyses dermatan sulfate (Chebi:63517 chain)" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004424 name: imidazoleglycerol-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H(2)O." [EC:4.2.1.19, RHEA:11040] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] xref: EC:4.2.1.19 xref: KEGG:R03457 xref: MetaCyc:IMIDPHOSDEHYD-RXN xref: RHEA:11040 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004425 name: indole-3-glycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] xref: EC:4.1.1.48 xref: MetaCyc:IGPSYN-RXN xref: RHEA:23476 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004427 name: inorganic diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + H(2)O = H(+) + 2 phosphate." [EC:3.6.1.1, RHEA:24576] synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] xref: EC:3.6.1.1 xref: KEGG:R00004 xref: MetaCyc:INORGPYROPHOSPHAT-RXN xref: reactome:R-HSA-449937 "pyrophosphate + H2O => 2 orthophosphate [mitochondrial]" xref: reactome:R-HSA-6788912 "LHPP:Mg2+ dimer hydrolyses PPi" xref: reactome:R-HSA-71732 "pyrophosphate + H2O => 2 orthophosphate [cytosolic]" xref: RHEA:24576 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004428 name: obsolete inositol or phosphatidylinositol kinase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. synonym: "inositol or phosphatidylinositol kinase activity" EXACT [] synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] is_obsolete: true consider: GO:0016307 consider: GO:0019140 consider: GO:0052742 consider: GO:0052813 [Term] id: GO:0004430 name: 1-phosphatidylinositol 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = 1-phosphatidyl-1D-myo-inositol 4-phosphate + ADP + 2 H(+)." [EC:2.7.1.67, RHEA:19877] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] synonym: "PI kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4K" BROAD [EC:2.7.1.67] synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] xref: EC:2.7.1.67 xref: KEGG:R03361 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN xref: reactome:R-HSA-1675780 "PI is phosphorylated to PI4P by PI4K2A/B at the plasma membrane" xref: reactome:R-HSA-1675813 "PI is phosphorylated to PI4P by PI4KA/2B at the ER membrane" xref: reactome:R-HSA-1675883 "PI is phosphorylated to PI4P by PI4KB at the Golgi membrane" xref: reactome:R-HSA-1675974 "PI is phosphorylated to PI4P by PI4K2A/B at the early endosome membrane" xref: reactome:R-HSA-1676185 "PI is phosphorylated to PI4P by PI4KA/2A/2B at the Golgi membrane" xref: RHEA:19877 is_a: GO:0052742 ! phosphatidylinositol kinase activity [Term] id: GO:0004432 name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IA namespace: molecular_function def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" EXACT [] is_obsolete: true consider: GO:0016308 [Term] id: GO:0004433 name: obsolete 1-phosphatidylinositol-4-phosphate kinase, class IB namespace: molecular_function def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" EXACT [] is_obsolete: true consider: GO:0016308 [Term] id: GO:0004435 name: phosphatidylinositol phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1,2-diacylglycerol + 1D-myo-inositol 1,4,5-trisphosphate + H(+)." [EC:3.1.4.11, RHEA:23915] synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] synonym: "phosphoinositide phospholipase C activity" EXACT [EC:3.1.4.11] synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] xref: EC:3.1.4.11 xref: KEGG:R03435 xref: MetaCyc:3.1.4.11-RXN xref: reactome:R-HSA-111879 "PIP2 hydrolysis" xref: reactome:R-HSA-167686 "Active PLCG1 hydrolyses PIP2" xref: reactome:R-HSA-1855177 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by cytosolic PLC[2] at the plasma membrane" xref: reactome:R-HSA-1855214 "PL(C)D4:3xCa2+ hydrolse PI(4,5)P2 to I(1,4,5)P3 and DAG at the ER membrane" xref: reactome:R-HSA-1855221 "PI(4,5)P2 is hydrolysed to I(1,4,5)P3 and DAG by tethered PLC[1] at the plasma membrane" xref: reactome:R-HSA-202407 "PLC-gamma1 hydrolyses PIP2" xref: reactome:R-HSA-2730847 "Hydrolysis of PIP2 by PLCG" xref: reactome:R-HSA-5607735 "p-Y753,Y759-PLCG2 hydrolyses PIP2" xref: reactome:R-HSA-622382 "PIP2 hydrolysis" xref: reactome:R-HSA-9032478 "EPOR-associated PLCG hydrolyzes 1-Phosphatidyl-1D-myo-inositol 4,5-bisphosphate" xref: RHEA:23915 is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0004436 name: phosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] comment: Note that this function was formerly EC:3.1.4.10. synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] xref: EC:4.6.1.13 xref: MetaCyc:3.1.4.10-RXN xref: RHEA:17093 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004437 name: obsolete inositol or phosphatidylinositol phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] comment: This term was made obsolete because it is a grouping term representing two quite different sets of entities, hexose sugars and glycerophospholipids. synonym: "inositol or phosphatidylinositol phosphatase activity" EXACT [] synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] is_obsolete: true consider: GO:0034593 consider: GO:0034594 consider: GO:0052744 consider: GO:0052745 [Term] id: GO:0004438 name: phosphatidylinositol-3-phosphatase activity namespace: molecular_function alt_id: GO:0016315 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] comment: Note that this function includes EC:3.1.3.65. synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] xref: EC:3.1.3.64 xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN xref: reactome:R-HSA-1675795 "PI3P is dephosphorylated to PI by MTM proteins at the late endosome membrane" xref: reactome:R-HSA-1675994 "PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane" xref: reactome:R-HSA-1676114 "PI3P is dephosphorylated to PI by SACM1L at the Golgi membrane" xref: reactome:R-HSA-1676141 "PI3P is dephosphorylated to PI by MTM proteins at the early endosome membrane" xref: reactome:R-HSA-6809325 "PI3P is dephosphorylated to PI by MTMR9-bound MTMR8 or MTMR6 at the plasma membrane" xref: reactome:R-HSA-6809720 "PI3P is dephosphorylated to PI by MTM1:MTMR12" xref: reactome:R-HSA-6809777 "PI3P is dephosphorylated to PI by MTMR2:SBF1" xref: reactome:R-HSA-6809975 "PI3P is dephosphorylated to PI by the MTMR2:SBF2 tetramer at the plasma membrane" xref: RHEA:12316 is_a: GO:0052744 ! phosphatidylinositol monophosphate phosphatase activity [Term] id: GO:0004439 name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function alt_id: GO:0001668 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36, RHEA:22764] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] synonym: "PI(4,5)P2 5-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PtdIns(4,5)P(2) 5-phosphatase activity" EXACT [EC:3.1.3.36, GOC:mah] synonym: "PtdIns(4,5)P2 5-phosphatase activity" EXACT [EC:3.1.3.36, GOC:mah] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] xref: EC:3.1.3.36 xref: KEGG:R04404 xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN xref: reactome:R-HSA-1675824 "PI(4,5)P2 is dephosphorylated to PI4P by OCRL/INPP5E at the Golgi membrane" xref: reactome:R-HSA-1676177 "PI(4,5)P2 is dephosphorylated to PI4P by SYNJ/INPP5[1] at the plasma membrane" xref: reactome:R-HSA-8868648 "SYNJ hydrolyze PI(4,5)P2 to PI(4)P" xref: RHEA:22764 is_a: GO:0034595 ! phosphatidylinositol phosphate 5-phosphatase activity is_a: GO:0106019 ! phosphatidylinositol-4,5-bisphosphate phosphatase activity [Term] id: GO:0004441 name: inositol-1,4-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] xref: EC:3.1.3.57 xref: MetaCyc:3.1.3.57-RXN xref: reactome:R-HSA-1855208 "I(1,4)P2 is dephosphorylated to I4P by INPP1 in the cytosol" xref: RHEA:15553 is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0004442 name: obsolete inositol-1,4,-bisphosphate 3-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] synonym: "inositol-1,4,-bisphosphate 3-phosphatase" EXACT [] is_obsolete: true consider: GO:0004438 [Term] id: GO:0004443 name: obsolete inositol-1,4,-bisphosphate 4-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] synonym: "inositol-1,4,-bisphosphate 4-phosphatase" EXACT [] is_obsolete: true consider: GO:0016316 [Term] id: GO:0004444 name: obsolete inositol-1,4,5-trisphosphate 1-phosphatase namespace: molecular_function def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] comment: This term was made obsolete because the existence of this function has not been established. synonym: "inositol-1,4,5-trisphosphate 1-phosphatase" EXACT [] is_obsolete: true consider: GO:0046030 [Term] id: GO:0004445 name: inositol-polyphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] comment: Note that this is a compound function and should be replaced by 'GO:0052659 : inositol 1,3,4,5-tetrakisphosphate 5-phosphatase activity' and 'GO:0052658 : inositol-1,4,5-trisphosphate 5-phosphatase activity'. synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" RELATED [] synonym: "inositol trisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.56] synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] xref: EC:3.1.3.56 is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0004446 name: inositol-hexakisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" NARROW [EC:3.1.3.62] synonym: "inositol tetrakisphosphate phosphomonoesterase activity" RELATED [EC:3.1.3.62] synonym: "MIPP activity" BROAD [EC:3.1.3.62] synonym: "multiple inositol-polyphosphate phosphatase activity" BROAD [EC:3.1.3.62] xref: EC:3.1.3.62 xref: MetaCyc:RXN-7920 is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0004447 name: iodide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: iodide + hydrogen peroxide = iodine + 2 H2O." [EC:1.11.1.8] synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] synonym: "iodinase activity" RELATED [EC:1.11.1.8] synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] synonym: "TPO activity" RELATED [EC:1.11.1.8] synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] xref: EC:1.11.1.8 xref: MetaCyc:IODIDE-PEROXIDASE-RXN xref: RHEA:23336 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004448 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: MetaCyc:ISOCITDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004449 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN xref: reactome:R-HSA-70967 "isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]" xref: RHEA:23632 is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004450 name: isocitrate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] xref: EC:1.1.1.42 xref: MetaCyc:ISOCITDEH-RXN xref: reactome:R-HSA-389540 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" xref: reactome:R-HSA-389550 "isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+" xref: reactome:R-HSA-450984 "isocitrate + NADP+ => alpha-ketoglutarate + CO2 + NADPH + H+ [IDH2]" xref: RHEA:19629 is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004451 name: isocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate = glyoxylate + succinate." [EC:4.1.3.1, RHEA:13245] synonym: "ICL activity" EXACT [EC:4.1.3.1] synonym: "isocitrase activity" EXACT [EC:4.1.3.1] synonym: "isocitratase activity" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] synonym: "isocitritase activity" EXACT [EC:4.1.3.1] synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] xref: EC:4.1.3.1 xref: KEGG:R00479 xref: MetaCyc:ISOCIT-CLEAV-RXN xref: RHEA:13245 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004452 name: isopentenyl-diphosphate delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate." [EC:5.3.3.2, RHEA:23284] synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] xref: EC:5.3.3.2 xref: KEGG:R01123 xref: MetaCyc:IPPISOM-RXN xref: reactome:R-HSA-191382 "Isopentenyl pyrophosphate rearranges to dimethylallyl pyrophosphate" xref: RHEA:23284 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] subset: goslim_chembl synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN xref: RHEA:16393 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004454 name: ketohexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] xref: EC:2.7.1.3 xref: MetaCyc:KETOHEXOKINASE-RXN xref: reactome:R-HSA-70333 "KHK dimer phosphorylates Fru to Fru 1-P" xref: RHEA:18145 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004455 name: ketol-acid reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004456 name: phosphogluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H(2)O." [EC:4.2.1.12, RHEA:17277] synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] xref: EC:4.2.1.12 xref: KEGG:R02036 xref: MetaCyc:PGLUCONDEHYDRAT-RXN xref: RHEA:17277 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004457 name: lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: lactate + NAD+ = H+ + NADH + pyruvate." [GOC:ai, GOC:bf] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004458 name: D-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004459 name: L-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27, RHEA:23444] synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] xref: EC:1.1.1.27 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN xref: reactome:R-HSA-6807826 "LDHAL6B reduces PYR to LACT" xref: reactome:R-HSA-70510 "LDH tetramer oxidises LACT to PYR" xref: reactome:R-HSA-71849 "LDH tetramer reduces PYR to LACT" xref: RHEA:23444 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004460 name: L-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "cytochrome b2" RELATED [] synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004461 name: lactose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] xref: EC:2.4.1.22 xref: MetaCyc:LACTOSE-SYNTHASE-RXN xref: reactome:R-HSA-5653878 "B4GALT1:LALBA transfers Gal from UDP-Gal to Glc to form Lac" xref: RHEA:12404 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004462 name: lactoylglutathione lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5, RHEA:19069] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] synonym: "glyoxylase I" RELATED [EC:4.4.1.5] synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] xref: EC:4.4.1.5 xref: KEGG:R02530 xref: MetaCyc:GLYOXI-RXN xref: reactome:R-HSA-5694071 "GLO1 dimer:2xZn2+ transforms MGXL and GSH to (R)-S-LGSH" xref: RHEA:19069 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004463 name: leukotriene-A4 hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + leukotriene A(4) = leukotriene B(4)." [EC:3.3.2.6, RHEA:22324] synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4H" RELATED [EC:3.3.2.6] xref: EC:3.3.2.6 xref: KEGG:R03057 xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN xref: reactome:R-HSA-266072 "LTA4 is hydolysed to LTB4 by LTA4H" xref: RHEA:22324 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004464 name: leukotriene-C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C(4) = glutathione + leukotriene A(4)." [EC:4.4.1.20, RHEA:17617] comment: Note that this function was EC:2.5.1.37. synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] xref: EC:4.4.1.20 xref: KEGG:R03059 xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN xref: reactome:R-HSA-266050 "LTA4 is converted to LTC4 by LTC4S" xref: RHEA:17617 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004465 name: lipoprotein lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate, where the triacylglycerol is part of a lipoprotein." [EC:3.1.1.34, GOC:bf] synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] xref: EC:3.1.1.34 xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN xref: reactome:R-HSA-1482811 "DAG is hydrolyzed to 2-MAG by PNPLA2/3" xref: reactome:R-HSA-174757 "chylomicron => TG-depleted chylomicron + 50 long-chain fatty acids + 50 diacylglycerols" xref: reactome:R-HSA-2395768 "LPL hydrolyses TGs from mature CMs" xref: reactome:R-HSA-6789310 "LIPs hydrolyse TG to DAG and RCOOH" xref: reactome:R-HSA-8979996 "LIPs hydrolyze TG to DAG and LCFA" xref: reactome:R-HSA-8980228 "LIPG dimer hydrolyzes HDL-associated TAG to DAG and LCFA" is_a: GO:0004806 ! triglyceride lipase activity [Term] id: GO:0004466 name: long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13] synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] xref: EC:1.3.99.13 xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004467 name: long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.3] synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: reactome:R-HSA-159425 "Cytosolic cholate and chenodeoxycholate are conjugated with Coenzyme A (SLC27A5 BACS)" xref: reactome:R-HSA-192137 "THCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: reactome:R-HSA-193401 "THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: reactome:R-HSA-193407 "DHCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: reactome:R-HSA-193424 "DHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: reactome:R-HSA-193711 "3,7,24THCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: reactome:R-HSA-193727 "TetraHCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: reactome:R-HSA-193743 "3,7,24THCA is conjugated with Coenzyme A (SLC27A2 VLCS)" xref: reactome:R-HSA-193766 "TetraHCA is conjugated with Coenzyme A (SLC27A5 BACS)" xref: reactome:R-HSA-201035 "ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA" xref: reactome:R-HSA-2046085 "Activation of alpha-linolenic acid to alpha-linolenoyl-CoA" xref: reactome:R-HSA-2046098 "Activation of linoleic acid to linoleoyl-CoA" xref: reactome:R-HSA-548843 "ACSL3,4 ligate CoA to AA to form AA-CoA" xref: UM-BBD_enzymeID:e0025 is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0004468 name: lysine N-acetyltransferase activity, acting on acetyl phosphate as donor namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "LAT activity" EXACT [EC:2.3.1.32] synonym: "lysine acetyltransferase activity" EXACT [] synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] xref: EC:2.3.1.32 xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-5618328 "ATAT acetylates microtubules" xref: reactome:R-HSA-5693001 "NAT8,8B acetylate BACE1" xref: RHEA:14417 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004470 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732] synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] is_a: GO:0016615 ! malate dehydrogenase activity [Term] id: GO:0004471 name: malate dehydrogenase (decarboxylating) (NAD+) activity namespace: molecular_function alt_id: GO:0004472 alt_id: GO:0016619 def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+." [EC:1.1.1.38, EC:1.1.1.39] comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.38), see 'oxaloacetate decarboxylase activity ; GO:0008948'. synonym: "'malic' enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.38] synonym: "malate dehydrogenase (decarboxylating) activity" EXACT [EC:1.1.1.39] synonym: "malate dehydrogenase (oxaloacetate-decarboxylating) activity" EXACT [] synonym: "NAD-linked malic enzyme" RELATED [EC:1.1.1.38] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.38, EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.38, EC:1.1.1.39] xref: EC:1.1.1.38 xref: EC:1.1.1.39 xref: KEGG:R00214 xref: MetaCyc:1.1.1.39-RXN xref: MetaCyc:MALIC-NAD-RXN xref: reactome:R-HSA-9012268 "ME2:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: RHEA:12653 is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004473 name: malate dehydrogenase (decarboxylating) (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+." [EC:1.1.1.40] comment: For decarboxylation of oxaloacetate (the second substrate listed in EC:1.1.1.40), see 'oxaloacetate decarboxylase activity ; GO:0008948'. synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] xref: EC:1.1.1.40 xref: KEGG:R00216 xref: MetaCyc:MALIC-NADP-RXN xref: reactome:R-HSA-9012036 "ME1:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: reactome:R-HSA-9012349 "ME3:Mg2+ tetramer oxidatively decarboxylates MAL to PYR" xref: RHEA:18253 is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004474 name: malate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glyoxylate + H(2)O = (S)-malate + CoA + H(+)." [EC:2.3.3.9, RHEA:18181] comment: Note that this function was formerly EC:4.1.3.2. synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] xref: EC:2.3.3.9 xref: KEGG:R00472 xref: MetaCyc:MALSYN-RXN xref: RHEA:18181 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004475 name: mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GTP = diphosphate + GDP-alpha-D-mannose." [EC:2.7.7.13, RHEA:15229] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] xref: EC:2.7.7.13 xref: KEGG:R00885 xref: MetaCyc:2.7.7.13-RXN xref: reactome:R-HSA-446221 "Mannose-1-phosphate converted to GDP-Mannose" xref: RHEA:15229 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0004476 name: mannose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] xref: EC:5.3.1.8 xref: MetaCyc:MANNPISOM-RXN xref: reactome:R-HSA-532549 "MPI isomerises Fru6P to Man6P" xref: RHEA:12356 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004477 name: methenyltetrahydrofolate cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw] synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] xref: EC:3.5.4.9 xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN xref: reactome:R-HSA-200661 "10-formylTHF polyglutamate <=> 5,10-methenylTHF polyglutamate + H2O" xref: reactome:R-HSA-200740 "5,10-methenylTHF polyglutamate + H2O <=> 10-formylTHF polyglutamate" xref: reactome:R-HSA-6801328 "MTHFD2, D2L oxidise 5,10-methylene-THF to 5,10-methenyl-THF" xref: RHEA:23700 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004478 name: methionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] xref: EC:2.5.1.6 xref: MetaCyc:S-ADENMETSYN-RXN xref: reactome:R-HSA-174391 "MAT1A multimers transfer Ado from ATP to L-Met" xref: reactome:R-HSA-5603114 "MAT2B:MAT2A:K+:2Mg2+ transfers Ado from ATP to L-Met" xref: RHEA:21080 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004479 name: methionyl-tRNA formyltransferase activity namespace: molecular_function alt_id: GO:0001718 alt_id: GO:0070128 def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] xref: EC:2.1.2.9 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN xref: reactome:R-HSA-5389841 "MTFMT formylates methionyl-tRNA" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004481 name: methylene-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: MetaCyc:2.1.1.16-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004482 name: mRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA. m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] xref: EC:2.1.1.56 xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: reactome:R-HSA-77090 "Methylation of GMP-cap by RNA Methyltransferase" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004483 name: mRNA (nucleoside-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: MetaCyc:2.1.1.57-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004484 name: mRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] synonym: "protein lambda2" RELATED [EC:2.7.7.50] xref: EC:2.7.7.50 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: reactome:R-HSA-77081 "Formation of the CE:GMP intermediate complex" xref: reactome:R-HSA-77083 "Transfer of GMP from the capping enzyme GT site to 5'-end of mRNA" is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0004485 name: methylcrotonoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbut-2-enoyl-CoA + ATP + bicarbonate = trans-3-methylglutaconyl-CoA + ADP + 2 H(+) + phosphate." [EC:6.4.1.4, RHEA:13589] synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "MCCC activity" EXACT [GOC:bf] synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] xref: EC:6.4.1.4 xref: KEGG:R04138 xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN xref: reactome:R-HSA-508308 "beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O <=> beta-methylcrotonyl-CoA + ATP + CO2 [MCCA]" xref: reactome:R-HSA-70773 "beta-methylcrotonyl-CoA + ATP + CO2 <=> beta-methylglutaconyl-CoA + ADP + orthophosphate + H2O [MCCA]" xref: RHEA:13589 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004486 name: methylenetetrahydrofolate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15] synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw] synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1 xref: reactome:R-HSA-200644 "5,10-methyleneTHF polyglutamate + NADP+ <=> 5,10-methenylTHF polyglutamate + NADPH + H+" xref: reactome:R-HSA-200718 "5,10-methenylTHF polyglutamate + NADPH + H+ <=> 5,10-methyleneTHF polyglutamate + NADP+" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004487 name: methylenetetrahydrofolate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(+) = 5,10-methenyltetrahydrofolate + NADH." [EC:1.5.1.15, RHEA:22892] synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] xref: EC:1.5.1.15 xref: KEGG:R01218 xref: MetaCyc:1.5.1.15-RXN xref: reactome:R-HSA-6801462 "MTHFD2, D2L oxidise 5,10-methenyl-THF to 10-formyl-THF" xref: RHEA:22892 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004488 name: methylenetetrahydrofolate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP(+) = 5,10-methenyltetrahydrofolate + NADPH." [EC:1.5.1.5, RHEA:22812] synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: KEGG:R01220 xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN xref: RHEA:22812 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004489 name: methylenetetrahydrofolate reductase (NAD(P)H) activity namespace: molecular_function alt_id: GO:0008702 def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: KEGG:R01224 xref: KEGG:R07168 xref: MetaCyc:1.5.1.20-RXN xref: reactome:R-HSA-200676 "5,10-methyleneTHF polyglutamate + NADPH + H+ => 5-methylTHF polyglutamate + NADP+" xref: RHEA:19817 xref: RHEA:19821 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004490 name: methylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H(2)O." [EC:4.2.1.18, RHEA:21536] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] xref: EC:4.2.1.18 xref: KEGG:R02085 xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN xref: reactome:R-HSA-70785 "beta-methylglutaconyl-CoA + H2O <=> beta-hydroxy-beta-methylglutaryl-CoA" xref: RHEA:21536 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004491 name: methylmalonate-semialdehyde dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] synonym: "MSDH activity" EXACT [EC:1.2.1.27] xref: EC:1.2.1.27 xref: MetaCyc:1.2.1.27-RXN xref: reactome:R-HSA-70893 "methylmalonate semialdehyde + NAD+ + CoA => propionyl-CoA + CO2 + NADH + H+" xref: RHEA:20804 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004492 name: methylmalonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41] synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41] xref: EC:4.1.1.41 xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN xref: RHEA:21396 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004493 name: methylmalonyl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = (S)-methylmalonyl-CoA." [EC:5.1.99.1, RHEA:20553] synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] xref: EC:5.1.99.1 xref: KEGG:R02765 xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN xref: reactome:R-HSA-71020 "D-methylmalonyl-CoA <=> L-methylmalonyl-CoA" xref: RHEA:20553 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0004494 name: methylmalonyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-methylmalonyl-CoA = succinyl-CoA." [EC:5.4.99.2, RHEA:22888] synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] xref: EC:5.4.99.2 xref: KEGG:R00833 xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN xref: reactome:R-HSA-71010 "MUT isomerises L-MM-CoA to SUCC-CoA" xref: RHEA:22888 xref: UM-BBD_reactionID:r0922 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004495 name: mevaldate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004496 name: mevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + ATP = (R)-5-phosphomevalonate + ADP + 2 H(+)." [EC:2.7.1.36, RHEA:17065] synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] xref: EC:2.7.1.36 xref: KEGG:R02245 xref: MetaCyc:MEVALONATE-KINASE-RXN xref: reactome:R-HSA-191380 "Mevalonate is phosphorylated to mevalonate-5-phosphate" xref: RHEA:17065 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004497 name: monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732] subset: goslim_pir synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk] xref: reactome:R-HSA-143468 "MEOS oxidizes ethanol to acetaldehyde" xref: reactome:R-HSA-156526 "CYP1A2,3A4,3A5,2A13 oxidise AFB1 to AFXBO" xref: reactome:R-HSA-211882 "CYP3A7 can 6beta-hydroxylate testosterone" xref: reactome:R-HSA-211904 "CYP4F12 18-hydroxylates ARA" xref: reactome:R-HSA-211910 "CYP2C8 inactivates paclitaxel by 6alpha-hydroxylation" xref: reactome:R-HSA-211919 "CYP4F8 19-hydroxylates PGH2" xref: reactome:R-HSA-211924 "CYP4B1 12-hydroxylates ARA" xref: reactome:R-HSA-211929 "CYP2C19 5-hydroxylates omeprazole" xref: reactome:R-HSA-211948 "CYP3A4 can N-demethylate loperamide" xref: reactome:R-HSA-211951 "CYP1B1 4-hydroxylates EST17b" xref: reactome:R-HSA-211959 "CYP3A43 6b-hydroxylates TEST" xref: reactome:R-HSA-211960 "CYP2U1 19-hydroxylates ARA" xref: reactome:R-HSA-211962 "CYP4F11 16-hydroxylates 3OH-PALM" xref: reactome:R-HSA-211968 "CYP2W1 oxidises INDOL" xref: reactome:R-HSA-211988 "CYP2C9 inactivates tolbutamide by 4methyl-hydroxylation" xref: reactome:R-HSA-211991 "Cyclophosphamide is 4-hydroxylated by CYP2B6" xref: reactome:R-HSA-212004 "CYP2C18 initiates bioactivation of phenytoin by 4-hydroxylation" xref: reactome:R-HSA-212005 "CYP2F1 dehydrogenates 3-methylindole" xref: reactome:R-HSA-213175 "CYP3A4,5 oxidise AFB1 to AFXBO" xref: reactome:R-HSA-215526 "CYP4F3 20-hydroxylates LTB4" xref: reactome:R-HSA-2161795 "Arachidonic acid is hydroxylated to 16/17/18-HETE by CYP(1)" xref: reactome:R-HSA-2161814 "Arachidonic acid is hydroxylated to 19-HETE by CYP(2)" xref: reactome:R-HSA-2161890 "Arachidonic acid is epoxidated to 5,6-EET by CYP(4)" xref: reactome:R-HSA-2161899 "Arachidonic acid is epoxidated to 8,9/11,12/14,15-EET by CYP(5)" xref: reactome:R-HSA-2161940 "Arachidonic acid is hydroxylated to 20-HETE by CYP(3)" xref: reactome:R-HSA-2162191 "DMPhOH is hydroxylated to MDMQ10H2 by DMPhOH monooxygenase" xref: reactome:R-HSA-217258 "FMO2:FAD:Mg2+ S-oxidises MTZ" xref: reactome:R-HSA-5423647 "CYP2A13 oxidises AFM1 to AFM1E" xref: reactome:R-HSA-5423664 "CYP3A4,5 hydroxylates AFB1 to AFQ1" xref: reactome:R-HSA-5423672 "CYP1A2, 3A4 oxidise AFB1 to AFNBO" xref: reactome:R-HSA-5423678 "CYP1A2 hydroxylates AFB1 to AFM1" xref: reactome:R-HSA-5602295 "CYP4F22 20-hydroxylates TrXA3" xref: reactome:R-HSA-5662662 "Tyrosinase oxidises tyrosine to dopaquinone" xref: reactome:R-HSA-5662692 "Dopa is oxidized to dopaquinone by TYR" xref: reactome:R-HSA-5663050 "DHI and DHICA polymerise forming eumelanin" xref: reactome:R-HSA-6786239 "CYP4V2 omega-hydroxylates DHA to HDoHE" xref: reactome:R-HSA-76354 "Vinyl chloride is oxidized to 2-Chloroethylene oxide" xref: reactome:R-HSA-76373 "N-hydroxylation of 4-aminobiphenyl" xref: reactome:R-HSA-76386 "CYP1A2 S-demethylates 6MMP" xref: reactome:R-HSA-76397 "Acetaminophen oxidised to N-acetylbenzoquinoneimine (NAPQI)" xref: reactome:R-HSA-76416 "Benzene is hydroxylated to phenol" xref: reactome:R-HSA-76426 "N-atom dealkylation of caffeine" xref: reactome:R-HSA-76434 "Dehalogenation of carbon tetrachloride to form a free radical" xref: reactome:R-HSA-76456 "O-atom dealkylation of dextromethorphan" xref: reactome:R-HSA-76466 "CYP4A11 12-hydroxylates DDCX" xref: reactome:R-HSA-76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: reactome:R-HSA-76475 "Dehalogenation of the poly-halogenated hydrocarbon Halothane to form the acylhalide Trifluoroacetlychloride and hydrogen bromide" xref: reactome:R-HSA-8865107 "MICAL1 produces NADP+, H2O2" xref: reactome:R-HSA-9018874 "CYP monooxygenates EPA to 18(S)-HpEPE" xref: reactome:R-HSA-9027042 "CPY4 -oxidises 14(S)-HDHA to MaR-L1" xref: reactome:R-HSA-9027043 "CYPs hydroxylate DHA to 14(R)-HDHA" xref: reactome:R-HSA-9027044 "CYP4 -oxidises 14(R)-HDHA to MaR-L2" xref: reactome:R-HSA-9027302 "CYP2E1 oxidises 14(S)-HDHA to 14(S),21(R)-diHDHA and 14(S),21(S)-diHDHA" xref: reactome:R-HSA-9027321 "CYP2E1 oxidises 14(R)-HDHA to 14(R),21(R)-diHDHA and 14(R),21(S)-diHDHA" xref: reactome:R-HSA-9037761 "CYP1, CYP2 hydroxylate (N)PD1 to 22-OH-(N)PD1" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004498 name: calcidiol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + H(+) + NADPH + O(2) = calcitriol + H(2)O + NADP(+)." [EC:1.14.13.13, RHEA:20573] synonym: "1-hydroxylase-25-hydroxyvitamin D3 activity" RELATED [EC:1.14.13.13] synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13] synonym: "cytochrome P450 CYP27B" NARROW [] xref: EC:1.14.13.13 xref: KEGG:R03610 xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN xref: reactome:R-HSA-209868 "CYP27B1 hydroxylates 25(OH)D to 1,25(OH)2D" xref: RHEA:20573 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004499 name: N,N-dimethylaniline monooxygenase activity namespace: molecular_function alt_id: GO:0047076 def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin-containing monooxygenase activity" BROAD [EC:1.13.12.11] synonym: "FMO activity" RELATED [EC:1.13.12.11] synonym: "FMO-I" RELATED [EC:1.13.12.11] synonym: "FMO-II" RELATED [EC:1.13.12.11] synonym: "FMO1" RELATED [EC:1.13.12.11] synonym: "FMO2" RELATED [EC:1.13.12.11] synonym: "FMO3" RELATED [EC:1.13.12.11] synonym: "FMO4" RELATED [EC:1.13.12.11] synonym: "FMO5" RELATED [EC:1.13.12.11] synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] xref: EC:1.14.13.8 xref: MetaCyc:1.14.13.8-RXN xref: reactome:R-HSA-139970 "FMO3:FAD N-oxidises TMA to TMAO" xref: reactome:R-HSA-217255 "FMO1:FAD N-oxidises TAM" xref: RHEA:24468 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004500 name: dopamine beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + dopamine + O(2) = (R)-noradrenaline + dehydroascorbate + H(2)O." [EC:1.14.17.1, RHEA:19117] synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine b-hydroxylase activity" EXACT [] synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] xref: EC:1.14.17.1 xref: KEGG:R02535 xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN xref: reactome:R-HSA-209891 "Dopamine is oxidised to noradrenaline" xref: RHEA:19117 is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004501 name: ecdysone 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + Ecdysone + O(2) = 20-hydroxyecdysone + A + H(2)O." [EC:1.14.99.22, RHEA:14021] synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] synonym: "ecdysone 20-hydroxylase activity" EXACT [] synonym: "ecdysone modification" BROAD [] synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] xref: EC:1.14.99.22 xref: KEGG:R02374 xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN xref: RHEA:14021 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004502 name: kynurenine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+)." [EC:1.14.13.9, RHEA:20545] synonym: "kynurenine 3-hydroxylase activity" EXACT [] synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] xref: EC:1.14.13.9 xref: KEGG:R01960 xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN xref: reactome:R-HSA-71200 "kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O" xref: RHEA:20545 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004503 name: monophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1, GOC:bf, GOC:sart, PMID:4965136] comment: In mammals, L-DOPA can act as a cofactor for the catalyzed reaction; therefore in some resources L-DOPA is shown on both sides of the reaction. GO:0004503 describes the monooxygenation of the monophenol, L-tyrosine. For oxidation of diphenols (including L-DOPA and dopamine), consider instead the term 'catechol oxidase activity ; GO:0004097' and its children. synonym: "catecholase" RELATED [EC:1.14.18.1] synonym: "chlorogenic acid oxidase activity" RELATED [EC:1.14.18.1] synonym: "chlorogenic oxidase activity" RELATED [EC:1.14.18.1] synonym: "cresolase activity" RELATED [EC:1.14.18.1] synonym: "dopa oxidase" RELATED [EC:1.14.18.1] synonym: "L-tyrosine monooxygenase activity" EXACT [GOC:bf] synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxygenase" EXACT [PMID:2494997] synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenolase activity" EXACT [EC:1.14.18.1] synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidase activity" RELATED [EC:1.14.18.1] synonym: "o-diphenol oxidoreductase" RELATED [EC:1.14.18.1] synonym: "o-diphenol:O2 oxidoreductase activity" RELATED [EC:1.14.18.1] synonym: "o-diphenol:oxygen oxidoreductase" RELATED [EC:1.14.18.1] synonym: "phenol oxidase activity" BROAD [] synonym: "phenolase activity" BROAD [EC:1.14.18.1] synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] synonym: "prophenol oxidase activity" RELATED [GOC:sart] synonym: "prophenoloxidase activity" RELATED [] synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] synonym: "tyrosinase activity" EXACT [EC:1.14.18.1] synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] xref: EC:1.14.18.1 xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN xref: RHEA:18117 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004504 name: peptidylglycine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] synonym: "PAM activity" EXACT [EC:1.14.17.3] synonym: "PAM-A" RELATED [EC:1.14.17.3] synonym: "PAM-B" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004505 name: phenylalanine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] synonym: "PAH activity" EXACT [EC:1.14.16.1] synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: reactome:R-HSA-71118 "PAH tetramer hydroxylates L-Phe to L-Tyr" xref: RHEA:20273 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004506 name: squalene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADPH + O(2) + squalene = (S)-2,3-epoxysqualene + H(2)O + NADP(+)." [RHEA:25282] synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.13.132] synonym: "squalene epoxidase activity" EXACT [EC:1.14.13.132] synonym: "squalene hydroxylase activity" EXACT [EC:1.14.13.132] synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.13.132] synonym: "squalene,NADPH:oxygen oxidoreductase (2,3-epoxidizing) activity" EXACT [KEGG:R02874] synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.13.132] synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.13.132] xref: EC:1.14.13.132 xref: KEGG:R02874 xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN xref: reactome:R-HSA-191299 "Squalene is oxidized to its epoxide" xref: RHEA:25282 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004507 name: steroid 11-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] synonym: "cytochrome P450 CYP11B1" NARROW [] synonym: "cytochrome P450 CYP11B2" NARROW [] synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] synonym: "steroid 11-beta-hydroxylase activity" EXACT [] synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] xref: EC:1.14.15.4 xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN xref: reactome:R-HSA-193997 "CYP11B1 oxidises 11DCORT" xref: reactome:R-HSA-194017 "CYP11B2 oxidises 11DCORST to CORST" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004508 name: steroid 17-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9] synonym: "cytochrome P450 CYP17" NARROW [] synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9] synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9] synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9] xref: EC:1.14.99.9 xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN xref: reactome:R-HSA-193068 "CYP17A1 17-hydroxylates PREG" xref: reactome:R-HSA-193070 "Side chain cleavage of 17alpha-hydroxypregnenolone to yield DHA" xref: reactome:R-HSA-193072 "CYP17A1 17-hydroxylates P4" xref: reactome:R-HSA-193099 "CYP17A1 cleaves 17aHPROG to ANDST" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004509 name: steroid 21-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10] synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10] synonym: "cytochrome P450 CYP21A1" NARROW [] synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10] synonym: "steroid 21-hydroxylase activity" EXACT [] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10] xref: EC:1.14.99.10 xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN xref: reactome:R-HSA-193964 "CYP21A2 21-hydroxylates PROG" xref: reactome:R-HSA-193981 "CYP21A2 oxidises 17HPROG" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004510 name: tryptophan 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "L-tryptophan hydroxylase activity" EXACT [] synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] xref: EC:1.14.16.4 xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN xref: reactome:R-HSA-209828 "Tryptophan is hydroxylated" xref: RHEA:16709 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004511 name: tyrosine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] synonym: "tyrosine 3-hydroxylase activity" EXACT [] synonym: "tyrosine hydroxylase activity" EXACT [] xref: EC:1.14.16.2 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN xref: reactome:R-HSA-209823 "Tyrosine is hydroxylated to dopa" xref: RHEA:18201 is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004512 name: inositol-3-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate. This reaction requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4, RHEA:10716] synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] xref: EC:5.5.1.4 xref: KEGG:R07324 xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN xref: reactome:R-HSA-1855178 "Glc6P is isomerised to I3P by ISYNA1 in the cytosol" xref: RHEA:10716 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0004513 name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: MetaCyc:2.4.99.10-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0004514 name: nicotinate-nucleotide diphosphorylase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: CO(2) + diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + 2 H(+) + quinolinate." [EC:2.4.2.19, RHEA:12733] synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] xref: EC:2.4.2.19 xref: KEGG:R03348 xref: MetaCyc:QUINOPRIBOTRANS-RXN xref: reactome:R-HSA-197268 "QPRT transfers PRIB to QUIN to form NAMN" xref: RHEA:12733 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004515 name: nicotinate-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] xref: EC:2.7.7.18 xref: MetaCyc:NICONUCADENYLYLTRAN-RXN xref: reactome:R-HSA-197235 "NMNAT2 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: reactome:R-HSA-200474 "NMNAT3 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: reactome:R-HSA-200512 "NMNAT1 transfers an adenylyl group from ATP to NAMN to yield NAAD" xref: RHEA:22860 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004516 name: nicotinate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + nicotinate D-ribonucleotide = 5-phospho-alpha-D-ribose 1-diphosphate + H(+) + nicotinate." [EC:6.3.4.21, RHEA:13393] synonym: "niacin ribonucleotidase activity" EXACT [EC:6.3.4.21] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:6.3.4.21] synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:6.3.4.21] xref: EC:6.3.4.21 xref: KEGG:R01724 xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN xref: reactome:R-HSA-197186 "NAPRT1 dimer transfers PRIB to NCA to form NAMN" xref: RHEA:13393 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004517 name: nitric-oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] synonym: "nitric oxide synthase activity" EXACT [] synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "NO synthase activity" EXACT [EC:1.14.13.39] xref: EC:1.14.13.39 xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN xref: reactome:R-HSA-202127 "eNOS synthesizes NO" xref: reactome:R-HSA-418436 "Nitric Oxide Synthase (NOS) produces Nitric Oxide (NO)" xref: RHEA:24668 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', and 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906' do not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast xref: EC:3.1 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004519 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] xref: reactome:R-HSA-5358512 "MLH1:PMS2 makes single strand incision near insertion/deletion loop of 2 bases or more" xref: reactome:R-HSA-5358518 "MLH1:PMS2 makes single strand incision near 1-2 base mismatch" xref: reactome:R-HSA-5690990 "5'- incision of DNA by ERCC1:ERCC4 in GG-NER" xref: reactome:R-HSA-5693533 "DCLRE1C (ARTEMIS) processes DNA DSB ends" xref: reactome:R-HSA-72180 "Cleavage of mRNA at the 3'-end" is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004520 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] synonym: "DNA nicking activity" RELATED [GOC:mah] synonym: "endonuclease G activity" RELATED [] xref: reactome:R-HSA-110359 "APEX1 mediates endonucleolytic cleavage at the 5' side of the AP site" xref: reactome:R-HSA-5686440 "MUS81:EME1,EME2 cleaves D-loop" xref: reactome:R-HSA-5686657 "ERCC1:XPF cleaves flaps generated by SSA" xref: reactome:R-HSA-5687464 "MRN and RBBP8 resect DNA DSBs in MMEJ" xref: reactome:R-HSA-5690988 "3'-incision of DNA by ERCC5 (XPG) in GG-NER" xref: reactome:R-HSA-5693584 "Cleavage of Holliday junctions by GEN1 or SLX1A:SLX4:MUS81:EME1,(MUS81:EME2)" xref: reactome:R-HSA-5693608 "Initial resection of double-strand break ends" xref: reactome:R-HSA-6782204 "5' incision of damaged DNA strand by ERCC1:ERCC4 in TC-NER" xref: reactome:R-HSA-6782224 "3' incision by ERCC5 (XPG) in TC-NER" xref: reactome:R-HSA-9023941 "MRN:CtIP endonucleolytically cleaves single-strand DNA 3' to SPO11" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004521 name: endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] synonym: "endonuclease G activity" RELATED [] xref: reactome:R-HSA-425923 "IRE1alpha hydrolyzes Xbp1 mRNA and Xbp1 mRNA is spliced" xref: reactome:R-HSA-426520 "Endonucleolytic RISC hydrolyzes target RNAs" xref: reactome:R-HSA-5601887 "PLD6 dimer cleaves primary piRNA transcript to pre-piRNA" xref: reactome:R-HSA-5601910 "Complexed PIWIL2:2'-O-methyl-piRNA cleaves transposon RNA" xref: reactome:R-HSA-6791223 "18SE pre-rRNA in pre-40S particles is nucleolytically processed during translocation from the nucleus to the cytosol" xref: reactome:R-HSA-6814555 "Integrator complex processes the 3' end of snRNA" xref: reactome:R-HSA-9009936 "RNASEL cleaves cellular ssRNA" xref: reactome:R-HSA-9009941 "RNASEL cleaves viral ssRNA" xref: reactome:R-HSA-9023909 "C3PO hydrolyzes cleaved passenger strand" xref: reactome:R-HSA-9023912 "AGO2 cleaves passenger strand of duplex siRNA" xref: reactome:R-HSA-927836 "SMG6 hydrolyzes mRNA with premature termination codon" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004522 name: ribonuclease A activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5] synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "endoribonuclease I" RELATED [EC:3.1.27.5] synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5] synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5] synonym: "pancreatic ribonuclease activity" NARROW [] synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5] synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5] synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5] synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5] synonym: "RNase A activity" EXACT [EC:3.1.27.5] synonym: "RNase activity" BROAD [EC:3.1.27.5] synonym: "RNase I activity" EXACT [EC:3.1.27.5] synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5] synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5] xref: EC:3.1.27.5 xref: MetaCyc:3.1.27.5-RXN xref: Wikipedia:Ribonuclease_A is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004523 name: RNA-DNA hybrid ribonuclease activity namespace: molecular_function alt_id: GO:0004524 def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. synonym: "calf thymus ribonuclease H activity" EXACT [] synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] synonym: "hybridase activity" EXACT [EC:3.1.26.4] synonym: "ribonuclease H activity" EXACT [GOC:vw] synonym: "ribonuclease H1 activity" NARROW [] synonym: "ribonuclease H2 activity" NARROW [] synonym: "ribonuclease H3 activity" NARROW [] synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] synonym: "RNase H activity" EXACT [] synonym: "RNase H1 activity" NARROW [] synonym: "RNase H2 activity" NARROW [] synonym: "RNase H3 activity" NARROW [] xref: EC:3.1.26.4 xref: MetaCyc:3.1.26.4-RXN xref: reactome:R-HSA-164519 "RNase H-mediated cleavage of the RNA strand of the -sssDNA:RNA duplex" xref: reactome:R-HSA-164528 "RNase H-mediated cleavage of the template strand" xref: reactome:R-HSA-173769 "RNase H-mediated digestion of tRNA, 3'PPT and cPPT RNA primers" xref: reactome:R-HSA-182795 "RNase H-mediated degradation of the template strand" xref: reactome:R-HSA-182859 "RNase H-mediated degradation of the RNA strand of the -sssDNA:RNA duplex" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004525 name: ribonuclease III activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] synonym: "RNase III activity" EXACT [EC:3.1.26.3] xref: EC:3.1.26.3 xref: MetaCyc:3.1.26.3-RXN xref: reactome:R-HSA-203862 "Dicer cleaves pre-miRNA to yield duplex miRNA" xref: reactome:R-HSA-203893 "Microprocessor complex cleaves pri-miRNA to pre-miRNA" xref: reactome:R-HSA-426464 "Dicer cleaves double-stranded RNA to yield double-stranded siRNA" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters is_a: GO:0032296 ! double-stranded RNA-specific ribonuclease activity [Term] id: GO:0004526 name: ribonuclease P activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] synonym: "RNase P" EXACT [] synonym: "tRNA 5' leader endonuclease activity" EXACT [] xref: EC:3.1.26.5 xref: MetaCyc:3.1.26.5-RXN xref: reactome:R-HSA-5696810 "RNase P cleaves the 5' end of pre-tRNA" xref: reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" xref: reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" xref: Wikipedia:RNase_P is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004527 name: exonuclease activity namespace: molecular_function alt_id: GO:0008857 def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] synonym: "exonuclease IX activity" NARROW [] is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004528 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: MetaCyc:3.1.4.1-RXN is_a: GO:0004527 ! exonuclease activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004529 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] is_a: GO:0004527 ! exonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004530 name: deoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] synonym: "DNAase activity" EXACT [EC:3.1.21.1] synonym: "DNase activity" NARROW [EC:3.1.21.1] synonym: "DNase I" RELATED [EC:3.1.21.1] synonym: "dornava" RELATED [EC:3.1.21.1] synonym: "dornavac" RELATED [EC:3.1.21.1] synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] xref: EC:3.1.21.1 xref: MetaCyc:3.1.21.1-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004531 name: deoxyribonuclease II activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] synonym: "acid DNase activity" EXACT [EC:3.1.22.1] synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] synonym: "DNase II activity" EXACT [EC:3.1.22.1] synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] xref: EC:3.1.22.1 xref: MetaCyc:3.1.22.1-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004532 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: reactome:R-HSA-429961 "DCPS scavenges the 7-methylguanosine cap of mRNA" is_a: GO:0004527 ! exonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004533 name: exoribonuclease H activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] xref: EC:3.1.13.2 xref: MetaCyc:3.1.13.2-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004534 name: 5'-3' exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: EC:3.1.13 xref: reactome:R-HSA-429845 "5' to 3' exoribonuclease hydrolyzes decapped mRNA" is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004535 name: poly(A)-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4] synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "poly(A)-specific RNase activity" EXACT [] xref: EC:3.1.13.4 xref: MetaCyc:3.1.13.4-RXN xref: reactome:R-HSA-429955 "CCR4-NOT complex deadenylates mRNA" xref: reactome:R-HSA-429992 "PARN deadenylates mRNA" xref: reactome:R-HSA-430021 "PAN2-PAN3 complex partially deadenylates mRNA" is_a: GO:0000175 ! 3'-5'-exoribonuclease activity [Term] id: GO:0004536 name: deoxyribonuclease activity namespace: molecular_function alt_id: GO:0004537 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] synonym: "caspase-activated deoxyribonuclease activity" NARROW [] xref: reactome:R-HSA-211247 "Cleavage of DNA by DFF40" xref: reactome:R-HSA-5685994 "Long-range resection of DNA DSBs by EXO1 or DNA2" xref: reactome:R-HSA-6785986 "DNA nucleases unhook the interstrand crosslink (ICL)" is_a: GO:0004518 ! nuclease activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0004540 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] is_a: GO:0004518 ! nuclease activity is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0004549 name: tRNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] synonym: "tRNA-specific RNase activity" EXACT [] xref: reactome:R-HSA-5696813 "TSEN complex cleaves the intron from pre-tRNA" xref: reactome:R-HSA-5696815 "ELAC2 cleaves the 3' end of pre-tRNA" xref: reactome:R-HSA-6785722 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the H strand transcript" xref: reactome:R-HSA-6786854 "Mitochondrial RNase P (mtRNase P) cleaves the 5' ends of pre-tRNAs and ELAC2 (RNase Z) cleaves the 3' ends of pre-tRNAs in the L strand transcript" is_a: GO:0004540 ! ribonuclease activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004550 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: reactome:R-HSA-2162096 "carbovir diphosphate + ATP => carbovir triphosphate + ADP" xref: reactome:R-HSA-482619 "(d)NDP + ATP <=> (d)NTP + ADP (NME1,2,3)" xref: reactome:R-HSA-482621 "(d)NTP + ADP <=> (d)NDP + ATP (NME1,2,3)" xref: reactome:R-HSA-482804 "(d)NDP + ATP <=> (d)NTP + ADP (NME4)" xref: reactome:R-HSA-482812 "(d)NTP + ADP <=> (d)NDP + ATP (NME4)" xref: reactome:R-HSA-6806877 "NME1:NME3 heterohexamer, NME2P1 phosphorylate NDPs to NTPs" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0004551 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN xref: reactome:R-HSA-196955 "2xENPP1 hydrolyzes FAD to FMN" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004552 name: octanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-octanol + NAD(+) = 1-octanal + H(+) + NADH." [EC:1.1.1.73, RHEA:24620] synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] xref: EC:1.1.1.73 xref: KEGG:R02878 xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN xref: RHEA:24620 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 xref: reactome:R-HSA-5694563 "ABHD10 hydrolyses MPAG" xref: reactome:R-HSA-6786652 "CHIT1 hydrolyses CHIT to 3xADGP" is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004555 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: MetaCyc:TREHALA-RXN xref: reactome:R-HSA-188985 "trehalose + H2O => 2 D-glucose" xref: RHEA:20868 is_a: GO:0015927 ! trehalase activity [Term] id: GO:0004556 name: alpha-amylase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units." [EC:3.2.1.1] synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] synonym: "endoamylase activity" EXACT [EC:3.2.1.1] synonym: "glycogenase activity" BROAD [EC:3.2.1.1] synonym: "taka-amylase A" RELATED [EC:3.2.1.1] xref: EC:3.2.1.1 xref: MetaCyc:ALPHA-AMYL-RXN xref: MetaCyc:RXN-1823 xref: MetaCyc:RXN-1825 xref: reactome:R-HSA-188979 "Digestion of linear starch (amylose) by extracellular amylase" xref: reactome:R-HSA-191114 "Digestion of branched starch (amylopectin) by extracellular amylase" is_a: GO:0016160 ! amylase activity [Term] id: GO:0004557 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN xref: reactome:R-HSA-1605736 "Alpha-galactosidase A removes a terminal galactose from alpha-D-galactoside oligomers" is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004558 name: alpha-1,4-glucosidase activity namespace: molecular_function alt_id: GO:0004562 alt_id: GO:0016982 def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->4)-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: MetaCyc:MALTODEXGLUCOSID-RXN xref: reactome:R-HSA-189053 "Digestion of 1-6 linkages of limit dextrins to yield maltose, maltotriose, longer maltosides, and glucose" xref: reactome:R-HSA-189102 "maltose + H2O => 2 D-glucose (maltase-glucoamylase)" xref: reactome:R-HSA-191101 "maltotriose + H2O => maltose + D-glucose (sucrase-isomaltase)" xref: reactome:R-HSA-191108 "maltose + H2O => 2 D-glucose (sucrase-isomaltase)" xref: reactome:R-HSA-191116 "maltotriose + H2O => maltose + D-glucose (maltase-glucoamylase)" xref: reactome:R-HSA-5659861 "isomaltose + H2O => 2 D-glucose (sucrase-isomaltase)" is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004559 name: alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] synonym: "1,2-alpha-D-mannosidase activity" NARROW [EC:3.2.1.24] synonym: "1,2-alpha-mannosidase" NARROW [EC:3.2.1.24] synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "p-nitrophenyl-alpha-mannosidase activity" NARROW [EC:3.2.1.24] xref: EC:3.2.1.24 xref: MetaCyc:3.2.1.24-RXN xref: reactome:R-HSA-6799545 "MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5" xref: reactome:R-HSA-8853686 "MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3" is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004560 name: alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN xref: reactome:R-HSA-5693807 "FUCA1 hydrolyses NGP:1,6-GlcNAc" is_a: GO:0015928 ! fucosidase activity [Term] id: GO:0004561 name: alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "NAG activity" EXACT [EC:3.2.1.50] xref: EC:3.2.1.50 xref: MetaCyc:3.2.1.50-RXN xref: reactome:R-HSA-1678742 "NAGLU hydrolyses Heparan sulfate chain(4)" xref: reactome:R-HSA-2090038 "NAGLU hydrolyses heparan chain(2)" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004563 name: beta-N-acetylhexosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] xref: EC:3.2.1.52 xref: MetaCyc:3.2.1.52-RXN xref: reactome:R-HSA-1605595 "Hexosaminidase A cleaves GalNAc from GM2 to form GM3" xref: reactome:R-HSA-1605632 "Both hexosaminidase A and B can cleave GalNAc from globoside" xref: reactome:R-HSA-1638053 "HEXA,B cleave the terminal GalNAc from keratan sulfate" xref: reactome:R-HSA-2105001 "HEXA,B cleaves the terminal GalNAc from DS" xref: reactome:R-HSA-2162225 "HEXA,B cleave the terminal GalNAc from small HA fragments" is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004564 name: beta-fructofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985] synonym: "acid invertase activity" BROAD [] synonym: "alkaline invertase activity" BROAD [] synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] synonym: "beta-fructosidase activity" RELATED [] synonym: "beta-h-fructosidase activity" RELATED [] synonym: "fructosylinvertase activity" RELATED [] synonym: "glucosucrase activity" RELATED [] synonym: "invertase activity" BROAD [] synonym: "invertin activity" BROAD [] synonym: "maxinvert L 1000 activity" RELATED [] synonym: "saccharase activity" RELATED [] xref: EC:3.2.1.26 xref: MetaCyc:RXN-9985 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004565 name: beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "hydrolact" RELATED [EC:3.2.1.23] synonym: "lactose hydrolysis" RELATED [] synonym: "lactozym" RELATED [EC:3.2.1.23] synonym: "maxilact" RELATED [EC:3.2.1.23] synonym: "oryzatym" RELATED [EC:3.2.1.23] synonym: "S 2107" RELATED [EC:3.2.1.23] synonym: "sumiklat" RELATED [EC:3.2.1.23] synonym: "trilactase activity" EXACT [EC:3.2.1.23] xref: EC:3.2.1.23 xref: MetaCyc:3.2.1.23-RXN xref: MetaCyc:BGALACT-PWY xref: reactome:R-HSA-1605624 "Beta-galactosidase hydrolyses GM1 to GM2" xref: reactome:R-HSA-1606312 "Beta-galactosidase can also hydrolyse globosides to form cerebrosides" xref: reactome:R-HSA-1630306 "GLB1 hydrolyses a glycosaminoglycan" xref: reactome:R-HSA-1793217 "Keratan sulfate is cleaved from its proteoglycan by an unknown galactosidase" xref: reactome:R-HSA-2090079 "GLB1 hydrolyses linker chain(2)" is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004566 name: beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "ketodase activity" EXACT [EC:3.2.1.31] xref: EC:3.2.1.31 xref: MetaCyc:BETA-GLUCURONID-RXN xref: reactome:R-HSA-1678854 "GUSB tetramer hydrolyses CS/HS precursor" xref: reactome:R-HSA-2162226 "GUSB tetramer hydrolyses GlcA-1,3-GlcNAc" xref: reactome:R-HSA-2162227 "GUSB tetramer hydrolyses (HA)2" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004567 name: beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannase activity" EXACT [EC:3.2.1.25] xref: EC:3.2.1.25 xref: MetaCyc:3.2.1.25-RXN xref: reactome:R-HSA-8853710 "MANBA hydrolyses GlcNAc:Man" is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins." [EC:3.2.1.14, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] xref: EC:3.2.1.14 xref: MetaCyc:3.2.1.14-RXN xref: reactome:R-HSA-6786421 "CHIA hydrolyses chitin" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004569 name: glycoprotein endo-alpha-1,2-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: MetaCyc:3.2.1.130-RXN xref: reactome:R-HSA-964759 "Alternative endo-mannosidase I route" is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0004571 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal (1->2)-linked alpha-D-mannose residues in an oligo-mannose oligosaccharide." [GOC:bf, PMID:25092655] synonym: "1,2-alpha-mannosidase" EXACT [EC:3.2.1.113] synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] synonym: "Man9-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "man9-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "ManI activity" NARROW [EC:3.2.1.113] synonym: "mannose-9 processing alpha-mannosidase activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] synonym: "mannosidase I" RELATED [EC:3.2.1.113] xref: EC:3.2.1.113 xref: KEGG:R05982 xref: KEGG:R06722 xref: MetaCyc:3.2.1.113-RXN xref: reactome:R-HSA-6782685 "EDEM1,3 hydrolyse (GlcNAc)2 (Man)8b to (GlcNAc)2 (Man)5" xref: reactome:R-HSA-901024 "MAN1B1 hydrolyses 1,2-linked mannose (a branch)" xref: reactome:R-HSA-901036 "MAN1B1 hydrolyses a second 1,2-linked mannose (a branch)" xref: reactome:R-HSA-901039 "MAN1B1 hydrolyses 1,2-linked mannose (c branch)" xref: reactome:R-HSA-901074 "MAN1B1,EDEM2 hydrolyse 1,2-linked mannose (b branch)" xref: reactome:R-HSA-964737 "Progressive trimming of alpha-1,2-linked mannose residues from Man9GlcNAc2 to produce Man5GlcNAc2" xref: reactome:R-HSA-964825 "Progressive trimming of alpha-1,2-linked mannose residues from Man8GlcNAc2 to produce Man5GlcNAc2" xref: reactome:R-HSA-964830 "Progressive trimming of alpha-1,2-linked mannose residues from Man7GlcNAc2 to produce Man5GlcNAc2" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004572 name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal (1->3)- and (1->6)-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] synonym: "alpha-(1,3/6)-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "ManII activity" NARROW [EC:3.2.1.114] synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] synonym: "mannosyl-oligosaccharide (1->3)-(1->6)-alpha-mannosidase activity" EXACT [] synonym: "mannosyl-oligosaccharide (1->3,6)-alpha-mannosidase activity" EXACT [] synonym: "mannosyl-oligosaccharide (1->3/6)-alpha-mannosidase activity" EXACT [] xref: EC:3.2.1.114 xref: MetaCyc:3.2.1.114-RXN xref: reactome:R-HSA-975814 "Trimming of mannoses on the alpha1,6 arm by MAN2A1" is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004573 name: mannosyl-oligosaccharide glucosidase activity namespace: molecular_function def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] xref: EC:3.2.1.106 xref: MetaCyc:3.2.1.106-RXN xref: reactome:R-HSA-532678 "Trimming of the first glucose by by mannosyl-oligosaccharide glucosidase" is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004574 name: oligo-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->6)-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose. Releases a free alpha-D-glucose." [EC:3.2.1.10] synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] synonym: "alpha-methylglucosidase activity" RELATED [GOC:rb] synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "isomaltase activity" RELATED [EC:3.2.1.10] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] xref: EC:3.2.1.10 xref: MetaCyc:3.2.1.10-RXN is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004575 name: sucrose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461] synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" BROAD [] synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" BROAD [] synonym: "intestinal sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase activity" RELATED [EC:3.2.1.48] synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose hydrolysis" BROAD [] synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] xref: EC:3.2.1.48 xref: KEGG:R00802 xref: MetaCyc:RXN-1461 xref: reactome:R-HSA-189069 "sucrose + H2O => glucose + fructose" is_a: GO:0004564 ! beta-fructofuranosidase activity is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0004576 name: oligosaccharyl transferase activity namespace: molecular_function def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119, GOC:mah] xref: EC:2.4.1 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004577 name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] xref: EC:2.4.1.141 xref: MetaCyc:2.4.1.141-RXN xref: reactome:R-HSA-446207 "ALG13:ALG14 transfers GlcNAc from UDP-GlcNAc to GlcNAcDOLP" is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004578 name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] xref: EC:2.4.1.142 xref: MetaCyc:2.4.1.142-RXN xref: reactome:R-HSA-446218 "Addition of the first mannose to the N-glycan precursor by ALG1" is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0004579 name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119] xref: EC:2.4.1.119 xref: MetaCyc:2.4.1.119-RXN xref: reactome:R-HSA-446209 "Transfer of N-glycan to the protein" is_a: GO:0004576 ! oligosaccharyl transferase activity [Term] id: GO:0004581 name: dolichyl-phosphate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] xref: EC:2.4.1.117 xref: MetaCyc:2.4.1.117-RXN xref: reactome:R-HSA-446214 "Synthesis of dolichyl-phosphate-glucose" xref: RHEA:15401 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004582 name: dolichyl-phosphate beta-D-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "DPM synthase activity" EXACT [] synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] xref: EC:2.4.1.83 xref: MetaCyc:2.4.1.83-RXN xref: reactome:R-HSA-162721 "dolichyl phosphate + GDP-alpha-D-mannose -> dolichyl phosphate D-mannose" xref: RHEA:21184 is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004583 name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah] xref: MetaCyc:RXN-5472 xref: reactome:R-HSA-446189 "Addition of a second glucose to the N-glycan precursor by ALG8" xref: reactome:R-HSA-446194 "Addition of a third glucose to the N-glycan precursor by an ALG10 homologue" xref: reactome:R-HSA-446202 "Addition of the first glucose to the N-glycan precursor by ALG6" is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0004584 name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] comment: This term represents EC 2.4.1.130 and was too unspecific and covered several different enzymes with non-overlapping catalytic activities. Consider one of the following: GO:0052925, GO:0052926, GO:0052917 or GO:0052918. GO:0004584 is scheduled for obsoletion. synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "oligomannosylsynthase activity" BROAD [EC:2.4.1.130] xref: EC:2.4.1.130 xref: MetaCyc:2.4.1.130-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004585 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: MetaCyc:RXN-13482 xref: reactome:R-HSA-70560 "carbamoyl phosphate + ornithine => citrulline + orthophosphate" xref: RHEA:19513 is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004586 name: ornithine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + H(+) = CO(2) + putrescine." [EC:4.1.1.17, RHEA:22964] synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] synonym: "SpeC" RELATED [EC:4.1.1.17] xref: EC:4.1.1.17 xref: KEGG:R00670 xref: MetaCyc:ORNDECARBOX-RXN xref: reactome:R-HSA-70692 "ornithine => putrescine + CO2" xref: RHEA:22964 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004587 name: ornithine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] synonym: "GabT" RELATED [EC:2.6.1.13] synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "OAT" RELATED [EC:2.6.1.13] synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: reactome:R-HSA-70654 "ornithine + alpha-ketoglutarate <=> glutamate + L-glutamate gamma-semialdehyde [OAT]" xref: reactome:R-HSA-70666 "glutamate + L-glutamate gamma-semialdehyde <=> ornithine + alpha-ketoglutarate [OAT]" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004588 name: orotate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] synonym: "OPRT activity" EXACT [EC:2.4.2.10] synonym: "OPRTase activity" EXACT [EC:2.4.2.10] synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] xref: EC:2.4.2.10 xref: MetaCyc:OROPRIBTRANS-RXN xref: reactome:R-HSA-73567 "orotate + 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) <=> orotidine 5'-monophosphate (OMP) + pyrophosphate" xref: RHEA:10380 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004589 name: orotate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NAD(+) = H(+) + NADH + orotate." [EC:1.3.1.14, RHEA:13513] synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] xref: EC:1.3.1.14 xref: KEGG:R01869 xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN xref: RHEA:13513 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004590 name: orotidine-5'-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + orotidine 5'-phosphate = CO(2) + UMP." [EC:4.1.1.23, RHEA:11596] synonym: "ODCase activity" EXACT [EC:4.1.1.23] synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "OMP-DC" RELATED [EC:4.1.1.23] synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] xref: EC:4.1.1.23 xref: KEGG:R00965 xref: MetaCyc:OROTPDECARB-RXN xref: reactome:R-HSA-73564 "orotidine 5'-monophosphate => uridine 5'-monophosphate + CO2" xref: RHEA:11596 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004591 name: oxoglutarate dehydrogenase (succinyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] synonym: "AKGDH activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "OGDC activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: MetaCyc:2OXOGLUTDECARB-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004592 name: pantoate-beta-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] xref: EC:6.3.2.1 xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN xref: RHEA:10912 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004593 name: pantothenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantothenate + H(2)O = (R)-pantoate + beta-alanine." [EC:3.5.1.22, RHEA:12448] synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] xref: EC:3.5.1.22 xref: KEGG:R02474 xref: MetaCyc:PANTOTHENASE-RXN xref: RHEA:12448 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004594 name: pantothenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] xref: EC:2.7.1.33 xref: MetaCyc:PANTOTHENATE-KIN-RXN xref: reactome:R-HSA-196857 "PANK2 phosphorylates PanK" xref: reactome:R-HSA-199203 "PANK1/3/4 phosphorylate PanK" xref: RHEA:16373 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004595 name: pantetheine-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate." [EC:2.7.7.3, RHEA:19801] synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] synonym: "PPAT activity" EXACT [EC:2.7.7.3] xref: EC:2.7.7.3 xref: KEGG:R03035 xref: MetaCyc:PANTEPADENYLYLTRAN-RXN xref: reactome:R-HSA-196754 "COASY transfers an adenylyl group from ATP to PPANT" xref: RHEA:19801 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004596 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide. This reaction is the acetylation of the N-terminal amino acid residue of a peptide or protein." [EC:2.3.1.88, GOC:mah] synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "NAT activity" RELATED [EC:2.3.1.88] synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] xref: EC:2.3.1.88 xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-6814090 "NatC acetylates ARFFRP1" is_a: GO:0034212 ! peptide N-acetyltransferase activity [Term] id: GO:0004597 name: peptide-aspartate beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] xref: EC:1.14.11.16 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004598 name: peptidylamidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] synonym: "HGAD" RELATED [EC:4.3.2.5] synonym: "PAL" RELATED [EC:4.3.2.5] synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN is_a: GO:0016842 ! amidine-lyase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004600 name: obsolete cyclophilin namespace: molecular_function def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732] comment: This term was made obsolete because it does not represent a molecular function. synonym: "cyclophilin" EXACT [] is_obsolete: true consider: GO:0003755 consider: GO:0016018 [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + hydrogen peroxide = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: goslim_metagenomics synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.7 xref: KEGG:R03532 xref: MetaCyc:PEROXID-RXN xref: reactome:R-HSA-1222346 "AhpC reduces H2O2" xref: reactome:R-HSA-140359 "PGG2 is reduced to PGH2 by PTGS1" xref: reactome:R-HSA-209815 "Tyrosine is monoiodinated" xref: reactome:R-HSA-209840 "Two DITs combine to form thyroxine" xref: reactome:R-HSA-209925 "DIT and MIT combine to form triiodothyronine" xref: reactome:R-HSA-209973 "Tyrosine is diiodinated" xref: reactome:R-HSA-2309773 "PGG2 is reduced to PGH2 by PTGS2" xref: reactome:R-HSA-2559639 "Collagen type IV sulfilimine cross-linking by peroxidasin" xref: reactome:R-HSA-3341296 "GPX7,8 catalyze peroxidation of P4HB (PDI)" xref: reactome:R-HSA-350901 "Iodide is organified" xref: reactome:R-HSA-5631885 "PRDX1 overoxidizes" xref: reactome:R-HSA-6789031 "Membrane-bound myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" xref: reactome:R-HSA-6789126 "Myeloperoxidase (MPO) produces hypochlorous acid (HOCl)" xref: reactome:R-HSA-8855490 "Lactoperoxidase (LPO) produces OSCN-" xref: reactome:R-HSA-8933635 "Myeloperoxidase (MPO) catalyzes oxidation of nitrite to nitrogen dioxide" xref: RHEA:23637 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0004602 name: glutathione peroxidase activity namespace: molecular_function alt_id: GO:0016224 def: "Catalysis of the reaction: 2 glutathione + hydrogen peroxide = oxidized glutathione + 2 H2O." [EC:1.11.1.9] synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: reactome:R-HSA-2161791 "15S-HpETE is reduced to 15S-HETE by GPX1/2/4" xref: reactome:R-HSA-2161946 "5S-HpETE is reduced to 5S-HETE by GPX1/2/4" xref: reactome:R-HSA-2161959 "12R-HpETE is reduced to 12R-HETE by GPX1/2/4" xref: reactome:R-HSA-2161999 "12S-HpETE is reduced to 12S-HETE by GPX1/2/4" xref: reactome:R-HSA-3323013 "GPX1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: reactome:R-HSA-3341277 "GPX2 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: reactome:R-HSA-3341397 "GPX3 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: reactome:R-HSA-3343700 "PRDX6:GSTP1 catalyzes 2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: reactome:R-HSA-6799695 "GPX5,6 reduce H2O2 to H2O" xref: reactome:R-HSA-71676 "2 glutathione, reduced + H2O2 => glutathione, oxidized + 2 H2O" xref: RHEA:16833 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004603 name: phenylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] xref: EC:2.1.1.28 xref: MetaCyc:2.1.1.28-RXN xref: reactome:R-HSA-209903 "Noradrenaline is converted to adrenaline" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004604 name: phosphoadenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-diphosphate + H(+) + sulfite + thioredoxin disulfide = 3'-phospho-5'-adenylyl sulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8, RHEA:11724] synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] xref: EC:1.8.4.8 xref: KEGG:R02021 xref: MetaCyc:1.8.4.8-RXN xref: RHEA:11724 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0004605 name: phosphatidate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "CDP-DG" RELATED [EC:2.7.7.41] synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CDP-diacylglycerol synthase activity" EXACT [] synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] synonym: "CDP-diglyceride synthase activity" EXACT [] synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] xref: EC:2.7.7.41 xref: MetaCyc:CDPDIGLYSYN-RXN xref: reactome:R-HSA-1483121 "PA is converted to CDP-DAG by CDS1" xref: reactome:R-HSA-1483165 "PA is converted to CDP-DAG by CDS2" xref: RHEA:16229 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004607 name: phosphatidylcholine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] synonym: "LCAT activity" EXACT [EC:2.3.1.43] synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] xref: EC:2.3.1.43 xref: MetaCyc:2.3.1.43-RXN xref: reactome:R-HSA-264695 "cholesterol + phosphatidylcholine (lecithin) => cholesterol ester + 2-lysophosphatidylcholine (lysolecithin)" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004608 name: phosphatidylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + H(+) + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17, RHEA:11164] synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] synonym: "LMTase activity" EXACT [EC:2.1.1.17] synonym: "PEMT" RELATED [EC:2.1.1.17] synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] xref: EC:2.1.1.17 xref: KEGG:R02056 xref: MetaCyc:2.1.1.17-RXN xref: reactome:R-HSA-1483174 "PE is methylated to PC by PEMT" xref: RHEA:11164 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004609 name: phosphatidylserine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + phosphatidyl-L-serine = CO(2) + phosphatidylethanolamine." [EC:4.1.1.65, RHEA:20828] synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] xref: EC:4.1.1.65 xref: KEGG:R02055 xref: MetaCyc:PHOSPHASERDECARB-RXN xref: reactome:R-HSA-1483212 "PS is decarboxylated to PE by PISD" xref: RHEA:20828 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004610 name: phosphoacetylglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-alpha-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3, RHEA:23804] synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] xref: EC:5.4.2.3 xref: KEGG:R08193 xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN xref: reactome:R-HSA-446185 "Isomerization of GlcNAc6P to GlcNAc1P" xref: RHEA:23804 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004611 name: phosphoenolpyruvate carboxykinase activity namespace: molecular_function def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2 + other reaction products." [EC:4.1.1.32] synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "PEPCK activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004612 name: phosphoenolpyruvate carboxykinase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + CO(2) + H(+) + phosphoenolpyruvate." [EC:4.1.1.49, RHEA:18617] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] synonym: "PEPK" RELATED [EC:4.1.1.49] synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] xref: EC:4.1.1.49 xref: KEGG:R00341 xref: MetaCyc:PEPCARBOXYKIN-RXN xref: RHEA:18617 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004613 name: phosphoenolpyruvate carboxykinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 xref: MetaCyc:4.1.1.32-RXN xref: reactome:R-HSA-372819 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [mitochondrial matrix]" xref: reactome:R-HSA-70241 "oxaloacetate + GTP => phosphoenolpyruvate + GDP + CO2 [cytosol]" xref: RHEA:10388 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004614 name: phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] xref: EC:5.4.2.2 xref: MetaCyc:PHOSPHOGLUCMUT-RXN xref: reactome:R-HSA-70272 "PGM:Mg2+ isomerise G6P to G1P" xref: reactome:R-HSA-70427 "PGM:Mg2+ isomerise G1P to G6P" xref: RHEA:23536 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004615 name: phosphomannomutase activity namespace: molecular_function alt_id: GO:0008971 def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8, RHEA:11140] synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] xref: EC:5.4.2.8 xref: KEGG:R01818 xref: MetaCyc:PHOSMANMUT-RXN xref: reactome:R-HSA-446201 "PMM1,2 isomerise Man6P to Man1P" xref: RHEA:11140 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004616 name: phosphogluconate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] synonym: "6PGD activity" EXACT [EC:1.1.1.44] synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] xref: EC:1.1.1.44 xref: MetaCyc:6PGLUCONDEHYDROG-RXN xref: reactome:R-HSA-71299 "6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+" xref: RHEA:10116 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004617 name: phosphoglycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "PGDH activity" EXACT [EC:1.1.1.95] synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: MetaCyc:PGLYCDEHYDROG-RXN xref: reactome:R-HSA-977348 "3-phosphoglycerate is dehydrogenated" xref: RHEA:12641 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004618 name: phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glycerate + ATP = 3-phospho-D-glyceroyl phosphate + ADP + H(+)." [EC:2.7.2.3, RHEA:14801] synonym: "3-PGK" RELATED [EC:2.7.2.3] synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "PGK" RELATED [EC:2.7.2.3] synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] xref: EC:2.7.2.3 xref: KEGG:R01512 xref: MetaCyc:PHOSGLYPHOS-RXN xref: reactome:R-HSA-70486 "ATP + 3-Phospho-D-glycerate <=> ADP + 1,3-bisphospho-D-glycerate" xref: reactome:R-HSA-71850 "1,3-bisphospho-D-glycerate + ADP <=> 3-phospho-D-glycerate + ADP" xref: RHEA:14801 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0004619 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: MetaCyc:3PGAREARR-RXN xref: reactome:R-HSA-71445 "2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate" xref: reactome:R-HSA-71654 "3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate" xref: RHEA:15901 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004620 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732] subset: goslim_chembl xref: EC:3.1.1 xref: reactome:R-HSA-6786650 "DDHD1,2 hydrolyse PA" xref: reactome:R-HSA-6792445 "LIPH, I hydrolyse PA to 2-acyl LPA" is_a: GO:0016298 ! lipase activity [Term] id: GO:0004621 name: glycosylphosphatidylinositol phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] synonym: "glycoprotein phospholipase D activity" EXACT [] synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] xref: EC:3.1.4.50 xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN xref: reactome:R-HSA-8940388 "GPLD1 hydrolyses GPI-anchors from proteins" xref: RHEA:10832 is_a: GO:0004630 ! phospholipase D activity [Term] id: GO:0004622 name: lysophospholipase activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: goslim_chembl synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN xref: reactome:R-HSA-1482545 "2-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: reactome:R-HSA-1482571 "1-acyl LPE is hydrolyzed to GPETA by PLA2G4C" xref: reactome:R-HSA-1482612 "2-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: reactome:R-HSA-1482629 "2-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: reactome:R-HSA-1482685 "1-acyl LPC is hydrolyzed to GPCho by PLA2[8]" xref: reactome:R-HSA-1482696 "1-acyl LPC is hydrolyzed to GPCho by PLA2G4C" xref: reactome:R-HSA-6814254 "PNPLA6 hydrolyzes LysoPtdCho" xref: reactome:R-HSA-6814766 "GDPD1 hydrolyzes LysoPtdCho" xref: reactome:R-HSA-6814778 "GDPD3 hydrolyzes LysoPtdCho" xref: reactome:R-HSA-8847912 "PNPLA7 hydrolyzes LysoPtdCho" xref: RHEA:15177 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004623 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: goslim_chembl synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN xref: reactome:R-HSA-1482604 "PA is hydrolyzed to 1-acyl LPA by PLA2[1] (OM)" xref: reactome:R-HSA-1482656 "PA is hydrolysed to 1-acyl LPA by PLA2[1]" xref: reactome:R-HSA-1482679 "PA is hydrolysed to 1-acyl LPA by PLA2G2A" xref: reactome:R-HSA-1482745 "PG is hydrolyzed to 1-acyl LPG by PLA2G4B (IM)" xref: reactome:R-HSA-1482759 "MLCL is hydrolyzed to DLCL by PLA2G4A (IM)" xref: reactome:R-HSA-1482771 "PS is hydrolyzed to 1-acyl LPS by PLA2[9]" xref: reactome:R-HSA-1482776 "PS is hydrolyzed to 1-acyl LPS by PLA2G2A" xref: reactome:R-HSA-1482778 "CL is hydrolyzed to MLCL by PLA2G6 (IM)" xref: reactome:R-HSA-1482816 "PC is hydrolyzed to 1-acyl LPC by PLA2[6]" xref: reactome:R-HSA-1482825 "PI is hydrolyzed to 1-acyl LPI by PLA2[11]" xref: reactome:R-HSA-1482856 "PC is hydrolyzed to 1-acyl LPC by PLA2[5]" xref: reactome:R-HSA-1482868 "PI is hydrolyzed to 1-acyl LPI by PLA2[12]" xref: reactome:R-HSA-1482884 "PE is hydrolyzed to 1-acyl LPE by PLA2[2]" xref: reactome:R-HSA-1482887 "PE is hydrolyzed to 1-acyl LPE by PLA2[3]" xref: reactome:R-HSA-1482897 "PS is hydrolyzed to 2-acyl LPS by PLA2[10]" xref: reactome:R-HSA-1482900 "PG is hydrolyzed to 1-acyl LPG by PLA2[1]" xref: reactome:R-HSA-1482907 "PG is hydrolyzed to 1-acyl LPG by PLA2G2A" xref: reactome:R-HSA-1602368 "PG is hydrolyzed to 1-acyl LPG by PLA2[16]" xref: reactome:R-HSA-1602374 "PS is hydrolyzed to 1-acyl LPS by PLA2[15]" xref: reactome:R-HSA-1602377 "PI is hydrolyzed to 1-acyl LPI by PLA2[15]" xref: reactome:R-HSA-1602398 "PE is hydrolyzed to 1-acyl LPE by PLA2[16]" xref: reactome:R-HSA-1602399 "PC is hydrolyzed to 1-acyl LPC by PLB1" xref: reactome:R-HSA-1602417 "PC is hydrolyzed to 1-acyl LPC by PLA2[16]" xref: reactome:R-HSA-1602446 "PA is hydrolyzed to 1-acyl LPA by PLA2[15]" xref: reactome:R-HSA-8848484 "PLA2s hydrolyze phospholipids at the Golgi membrane" xref: RHEA:15801 is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004624 name: obsolete secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "secreted phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0004623 consider: GO:0005576 [Term] id: GO:0004625 name: obsolete calcium-dependent secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-dependent secreted phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005576 consider: GO:0047498 [Term] id: GO:0004626 name: obsolete cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0004623 consider: GO:0005829 [Term] id: GO:0004627 name: obsolete calcium-dependent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-dependent cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005829 consider: GO:0047498 [Term] id: GO:0004628 name: obsolete calcium-independent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. synonym: "calcium-independent cytosolic phospholipase A2 activity" EXACT [] is_obsolete: true consider: GO:0005829 consider: GO:0047499 [Term] id: GO:0004629 name: phospholipase C activity namespace: molecular_function alt_id: GO:0042298 def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, GOC:mah] synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] synonym: "phosphatidase C" RELATED [EC:3.1.4.3] xref: EC:3.1.4.3 xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: reactome:R-HSA-1112666 "BLNK (SLP-65) Signalosome hydrolyzes phosphatidyinositol bisphosphate forming diacylglycerol and inositol-1,4,5-trisphosphate" xref: reactome:R-HSA-114688 "PLC-beta hydrolyses PIP2 to DAG and IP3" xref: reactome:R-HSA-114689 "PLC gamma 2-mediated PIP2 hydrolysis" xref: reactome:R-HSA-398193 "PLC beta-mediated PIP2 hydrolysis" xref: reactome:R-HSA-399998 "Activated Phospholipase C beta-1 hydrolyzes 1-Phosphatidyl-D-myo-inositol 4,5-bisphosphate" xref: reactome:R-HSA-5362553 "NOTUM releases Hh-Np:GPC5 from the plasma membrane" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004630 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: goslim_chembl synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN xref: reactome:R-HSA-1483142 "PC is transphosphatidylated to PG by PLD1-4/6" xref: reactome:R-HSA-1483182 "PC is hydrolyzed to PA and choline by PLD1/2" xref: reactome:R-HSA-2029471 "Hydrolysis of PC to PA by PLD" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004631 name: phosphomevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-5-phosphomevalonate + ATP = (R)-5-diphosphomevalonate + ADP + H(+)." [EC:2.7.4.2, RHEA:16341] synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] xref: EC:2.7.4.2 xref: KEGG:R03245 xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN xref: reactome:R-HSA-191422 "Mevalonate-5-phosphate is further phosphorylated." xref: RHEA:16341 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0004632 name: phosphopantothenate--cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: MetaCyc:P-PANTOCYSLIG-RXN xref: reactome:R-HSA-196753 "2xPPCS ligates PPanK with Cys" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004633 name: phosphopantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(R)-4-phosphonatopantothenoyl]-L-cysteinate + H(+) = CO(2) + pantetheine 4'-phosphate." [EC:4.1.1.36, RHEA:16793] synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] xref: EC:4.1.1.36 xref: KEGG:R03269 xref: MetaCyc:P-PANTOCYSDECARB-RXN xref: reactome:R-HSA-196840 "3xPPCDC:3FMN decarboxylates PPC" xref: RHEA:16793 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004634 name: phosphopyruvate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732] synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] synonym: "enolase activity" EXACT [EC:4.2.1.11] synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] xref: EC:4.2.1.11 xref: MetaCyc:2PGADEHYDRAT-RXN xref: reactome:R-HSA-70494 "Phosphoenolpyruvate + H2O <=> 2-Phospho-D-glycerate" xref: reactome:R-HSA-71660 "2-Phospho-D-glycerate <=> Phosphoenolpyruvate + H2O" xref: RHEA:10164 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004635 name: phosphoribosyl-AMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphonatoribosyl)-5'-AMP + H(2)O = 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide." [EC:3.5.4.19, RHEA:20049] synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] xref: EC:3.5.4.19 xref: KEGG:R04037 xref: MetaCyc:HISTCYCLOHYD-RXN xref: RHEA:20049 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004636 name: phosphoribosyl-ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + H(2)O = 1-(5-phosphonatoribosyl)-5'-AMP + diphosphate + H(+)." [EC:3.6.1.31, RHEA:22828] synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] xref: EC:3.6.1.31 xref: KEGG:R04035 xref: MetaCyc:HISTPRATPHYD-RXN xref: RHEA:22828 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004637 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-D-ribosylamine + ATP + glycine = N(1)-(5-phospho-D-ribosyl)glycinamide + ADP + 2 H(+) + phosphate." [EC:6.3.4.13, RHEA:17453] synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: KEGG:R04144 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: reactome:R-HSA-73814 "5-Phosphoribosylamine + Glycine + ATP => GAR + ADP + Pi" xref: RHEA:17453 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004638 name: phosphoribosylaminoimidazole carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + 2 H(+) = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)." [EC:4.1.1.21, RHEA:10792] synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] synonym: "ADE2" RELATED [EC:4.1.1.21] synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] synonym: "class II PurE" RELATED [EC:4.1.1.21] xref: EC:4.1.1.21 xref: KEGG:R04209 xref: MetaCyc:AIRCARBOXY-RXN xref: reactome:R-HSA-73806 "AIR + CO2 => CAIR" xref: RHEA:10792 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004639 name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate + ATP = (2S)-2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate + ADP + 2 H(+) + phosphate." [EC:6.3.2.6, RHEA:22628] synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "PurC" RELATED [EC:6.3.2.6] synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] synonym: "SAICARs activity" EXACT [EC:6.3.2.6] xref: EC:6.3.2.6 xref: KEGG:R04591 xref: MetaCyc:SAICARSYN-RXN xref: reactome:R-HSA-73805 "CAIR + Aspartate + ATP => SAICAR + ADP + Pi" xref: RHEA:22628 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004640 name: phosphoribosylanthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24, RHEA:21540] synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRAI activity" EXACT [EC:5.3.1.24] xref: EC:5.3.1.24 xref: KEGG:R03509 xref: MetaCyc:PRAISOM-RXN xref: RHEA:21540 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004641 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + ATP = 5-amino-1-(5-phospho-D-ribosyl)imidazole + ADP + 2 H(+) + phosphate." [EC:6.3.3.1, RHEA:23032] synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: KEGG:R04208 xref: MetaCyc:AIRS-RXN xref: reactome:R-HSA-73810 "FGAM + ATP => AIR + ADP + Pi" xref: RHEA:23032 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004642 name: phosphoribosylformylglycinamidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H(2)O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H(+) + phosphate." [EC:6.3.5.3, RHEA:17129] synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "FGARAT activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] xref: EC:6.3.5.3 xref: KEGG:R04463 xref: MetaCyc:FGAMSYN-RXN xref: reactome:R-HSA-73812 "FGAR + L-Glutamine + ATP + H2O => FGAM + L-Glutamate + ADP + Pi" xref: RHEA:17129 is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004643 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: MetaCyc:AICARTRANSFORM-RXN xref: reactome:R-HSA-73798 "AICAR + 10-Formyl-THF => FAICAR + THF" xref: RHEA:22192 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004644 name: phosphoribosylglycinamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] synonym: "GART activity" EXACT [EC:2.1.2.2] synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] xref: EC:2.1.2.2 xref: MetaCyc:GART-RXN xref: reactome:R-HSA-73813 "GAR + 10-Formyl-THF => FGAR + THF" xref: RHEA:15053 is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004645 name: phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] synonym: "myophosphorylase" NARROW [EC:2.4.1.1] synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] xref: EC:2.4.1.1 xref: MetaCyc:RXN-1826 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004647 name: phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: MetaCyc:PSERPHOSPHA-RXN xref: reactome:R-HSA-977324 "phosphoserine is dephosphorylated" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004648 name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity namespace: molecular_function alt_id: GO:0004646 def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "PdxC" RELATED [EC:2.6.1.52] synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphoserine aminotransferase activity" BROAD [] synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52] synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: MetaCyc:PSERTRANSAM-RXN xref: reactome:R-HSA-977333 "3-phosphonooxypyruvic acid + L-glutamate = O-phospho-L-serine + 2-oxoglutarate" xref: RHEA:14329 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004649 name: poly(ADP-ribose) glycohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] xref: EC:3.2.1.143 xref: MetaCyc:3.2.1.143-RXN xref: reactome:R-HSA-5651828 "PARG dePARylates PARP1,PARP2" xref: reactome:R-HSA-8952903 "ADPRHL2 hydrolyses poly(ADP-ribose)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004650 name: polygalacturonase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4)-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] synonym: "endo-D-galacturonase activity" EXACT [] synonym: "endo-polygalacturonase activity" EXACT [] synonym: "endogalacturonase activity" EXACT [] synonym: "endopolygalacturonase activity" EXACT [] synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] synonym: "pectinase activity" NARROW [EC:3.2.1.15] synonym: "pectolase activity" EXACT [EC:3.2.1.15] synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] xref: EC:3.2.1.15 xref: MetaCyc:RXN-2103 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004651 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: reactome:R-HSA-77078 "Hydrolysis of the 5'-end of the nascent transcript by the capping enzyme" is_a: GO:0098518 ! polynucleotide phosphatase activity [Term] id: GO:0004652 name: polynucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: reactome:R-HSA-72185 "mRNA polyadenylation" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004653 name: polypeptide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. This reaction is the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] xref: EC:2.4.1.41 xref: MetaCyc:2.4.1.41-RXN xref: reactome:R-HSA-8851619 "GALNT3 transfers GalNAc to FGF23" xref: reactome:R-HSA-913675 "GALNTs transfer GalNAc from UDP-GalNAc to mucins to form Tn antigens" is_a: GO:0008376 ! acetylgalactosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004654 name: polyribonucleotide nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: RNA(n+1) + phosphate <=> RNA(n) + a nucleoside diphosphate." [EC:2.7.7.8] synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: MetaCyc:2.7.7.8-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0004655 name: porphobilinogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 5-aminolevulinate = 2 H(2)O + H(+) + porphobilinogen." [EC:4.2.1.24, RHEA:24064] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] synonym: "aminolevulinate dehydratase activity" EXACT [] synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] xref: EC:4.2.1.24 xref: KEGG:R00036 xref: MetaCyc:PORPHOBILSYNTH-RXN xref: reactome:R-HSA-189439 "ALAD condenses 2 dALAs to form PBG" xref: RHEA:24064 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004656 name: procollagen-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] synonym: "peptidyl proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "proline, 2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" BROAD [EC:1.14.11.2] synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] xref: EC:1.14.11.2 xref: KEGG:R03219 xref: MetaCyc:1.14.11.2-RXN xref: reactome:R-HSA-1650808 "Prolyl 4-hydroxylase converts collagen prolines to 4-hydroxyprolines" is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity [Term] id: GO:0004657 name: proline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] xref: EC:1.5.99.8 xref: MetaCyc:RXN-7181 xref: reactome:R-HSA-6784224 "PRODH2:FAD dimer dehydrogenates HPRO to 1-pyrroline-3-hydroxy-5-carboxylate" xref: reactome:R-HSA-70670 "PRODH oxidises L-Pro to 1PYR-5COOH" xref: reactome:R-HSA-8955817 "PRODH2 oxidises HPRO to 1PYR-5COOH" xref: RHEA:23784 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0004658 name: propionyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] synonym: "PCCase activity" EXACT [EC:6.4.1.3] synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] xref: EC:6.4.1.3 xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN xref: reactome:R-HSA-71031 "propionyl-CoA + CO2 + ATP <=> D-methylmalonyl-CoA + ADP + orthophosphate" xref: RHEA:23720 is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004659 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] xref: MetaCyc:GPPSYN-RXN xref: reactome:R-HSA-6806674 "UBIA1D prenylates menadione to form MK4 (vitamin K hydroquinone)" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004660 name: protein farnesyltransferase activity namespace: molecular_function alt_id: GO:0018223 def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] comment: The catalyzed reaction transfers a farnesyl group from farnesyl diphosphate to a target protein. There is no relationship between this activity and farnesyltransferase activity, GO:0004311, where the catalyzed reaction forms (free) geranylgeranyl diphosphate. synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN xref: reactome:R-HSA-2530501 "FNTA:FNTB transfers FARN to GNGT1" is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004661 name: protein geranylgeranyltransferase activity namespace: molecular_function alt_id: GO:0018224 def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] xref: EC:2.5.1 is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004662 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004663 name: Rab geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004664 name: prephenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] xref: EC:4.2.1.51 xref: MetaCyc:PREPHENATEDEHYDRAT-RXN xref: RHEA:21648 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004665 name: prephenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADPH." [EC:1.3.1.13, RHEA:21640] synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] xref: EC:1.3.1.13 xref: KEGG:R01730 xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21640 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004666 name: prostaglandin-endoperoxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] xref: EC:1.14.99.1 xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN xref: reactome:R-HSA-140355 "Arachidonic acid is oxidised to PGG2 by PTGS1" xref: reactome:R-HSA-2309787 "Arachidonic acid is oxidised to PGG2 by PTGS2" xref: RHEA:23728 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004667 name: prostaglandin-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin D(2)." [EC:5.3.99.2, RHEA:10600] synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] xref: EC:5.3.99.2 xref: KEGG:R02266 xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN xref: reactome:R-HSA-2161620 "PGH2 is isomerised to PGD2 by PTGDS" xref: reactome:R-HSA-2161701 "PGH2 is isomerised to PGD2 by HPGDS" xref: RHEA:10600 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004668 name: protein-arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] xref: EC:3.5.3.15 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN xref: reactome:R-HSA-1183128 "PADIs:Ca2+ deiminate L-Arg to L-Cit in proteins" xref: reactome:R-HSA-3247569 "PADI4 deiminates Histones" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004671 name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity namespace: molecular_function alt_id: GO:0018225 def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein-S-isoprenylcysteine O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] xref: EC:2.1.1.100 xref: KEGG:R04496 xref: MetaCyc:2.1.1.100-RXN xref: reactome:R-HSA-6788650 "ICMT:Zn2+ transfers CH3 from AdoMet to isoprenylated proteins" is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_aspergillus subset: goslim_candida synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: reactome:R-HSA-111970 "PKC phosphorylates GRK2" xref: reactome:R-HSA-1362270 "Phosphorylation of LIN52 component of MuvB by DYRK1A" xref: reactome:R-HSA-156832 "INF-gamma induced phosphorylation of L13a" xref: reactome:R-HSA-164151 "LKB1 phosphorylates the alpha subunit of AMPK heterotrimer" xref: reactome:R-HSA-166286 "Multiple IRAK1 autophosphorylation steps" xref: reactome:R-HSA-2730887 "Autophosphorylation and activation of MEKK1" xref: reactome:R-HSA-354073 "Autophosphorylation of FADK1 at Y397" xref: reactome:R-HSA-354124 "Phosphorylation of pFADK1 by SRC" xref: reactome:R-HSA-372693 "Phosphorylation of p130Cas by SRC-FADK1 complex" xref: reactome:R-HSA-374664 "Phosphorylation and activation of Ezrin" xref: reactome:R-HSA-418163 "Activated Src activates ERK" xref: reactome:R-HSA-5218804 "p38 MAPK activation by VEGFR" xref: reactome:R-HSA-5607726 "Active NIK:p-S176,180-IKKA dimer phosphorylates p100:RELB" xref: reactome:R-HSA-74615 "PRKCA/Q phosphorylate RGS9-1:GN5B:RGS9BP" xref: reactome:R-HSA-8857583 "LINC01139 promotes phosphorylation of HIF1A by PTK6 and LRRK2" xref: reactome:R-HSA-8964242 "G protein alpha (i)-SRC complex catalyzes SRC to p-Y416-SRC" xref: reactome:R-HSA-8964252 "G alpha (s):GTP:SRC catalyzes SRC to p-Y416-SRC" xref: reactome:R-HSA-8983872 "JAK2 bound to IL12RB2:IL12RB2 phosphorylate STAT4" xref: reactome:R-HSA-918229 "Phosphorylation and release of IRF3/IRF7" xref: reactome:R-HSA-933525 "Phosphorylation and release of IRF7" xref: reactome:R-HSA-933530 "Activation of IKK by MEKK1" xref: reactome:R-HSA-937034 "IRAK1 phosphorylates Pellino" xref: reactome:R-HSA-937059 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:TIRAP:activated TLR complex" xref: reactome:R-HSA-9604606 "Unknown kinase phosphorylates NICD4" xref: reactome:R-HSA-975139 "IRAK1 phosphorylates Pellino upon TLR7/8 or 9 activation" xref: reactome:R-HSA-975853 "Multiple IRAK1 autophosphorylation within the complex p-IRAK4:oligo MyD88:activated TLR" xref: reactome:R-HSA-975861 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex" xref: reactome:R-HSA-975874 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR complex" xref: reactome:R-HSA-975878 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004673 name: protein histidine kinase activity namespace: molecular_function alt_id: GO:0008896 def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] synonym: "EnvZ" NARROW [EC:2.7.13.3] synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine kinase activity" EXACT [] synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] synonym: "HK1" RELATED [EC:2.7.13.3] synonym: "HP165" RELATED [EC:2.7.13.3] synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein-histidine kinase activity" EXACT [] synonym: "Sln1p" NARROW [EC:2.7.13.3] xref: EC:2.7.13.3 xref: MetaCyc:2.7.13.3-RXN is_a: GO:0004672 ! protein kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004695 alt_id: GO:0004696 alt_id: GO:0004700 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:bf] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] xref: EC:2.7.11 xref: reactome:R-HSA-109702 "PDPK1 phosphorylates AKT2" xref: reactome:R-HSA-109860 "MAP2K1 phosphorylates MAPK3" xref: reactome:R-HSA-109862 "MAP2K2 phosphorylates MAPK1" xref: reactome:R-HSA-111919 "PKA phosphorylates CREB1" xref: reactome:R-HSA-112342 "Inactivation of MAP2K1 by CDK1" xref: reactome:R-HSA-1168635 "PRKCB (PKC-beta) phosphorylates CARMA1" xref: reactome:R-HSA-1168638 "Activated IKK phosphorylates I-kappaB" xref: reactome:R-HSA-1168641 "TAK1 associated with the CBM complex phosphorylates IKKbeta" xref: reactome:R-HSA-1181149 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin" xref: reactome:R-HSA-1181156 "Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL" xref: reactome:R-HSA-1181355 "Phosphorylation of R-SMAD2/3 by NODAL receptor" xref: reactome:R-HSA-1225894 "Type II Activin Receptor (ActRIIB/ACVR2B) phosphorylates Type I Activin Receptor (ActRIC/ACVR1C) in response to NODAL" xref: reactome:R-HSA-1358791 "Phosphorylation of USP8 by P-AKT" xref: reactome:R-HSA-1433508 "PKC alpha interacts with and phosphorylates KIT" xref: reactome:R-HSA-1445144 "p-AKT1,p-AKT2 phosphorylates AS160 (TBC1D4)" xref: reactome:R-HSA-1449597 "p-AKT2 phosphorylates Myosin 5A" xref: reactome:R-HSA-1454699 "AMPK-alpha2 phosphorylates TBC1D1" xref: reactome:R-HSA-1458463 "p-AKT2 phosphorylates RGC2" xref: reactome:R-HSA-1549526 "Phosphorylation of SMAD2/3 by Activin:Activin Receptor" xref: reactome:R-HSA-156673 "Regulation of KIF23 (MKLP1) by phosphorylation" xref: reactome:R-HSA-156678 "Activation of Cdc25C" xref: reactome:R-HSA-156682 "Regulation of NUDC by phosphorylation" xref: reactome:R-HSA-156699 "Inactivation of Wee1 kinase" xref: reactome:R-HSA-156723 "Regulation of KIF20A (MKL2) by phosphorylation" xref: reactome:R-HSA-1592233 "p38 MAPK phosphorylates PPARGC1A" xref: reactome:R-HSA-162363 "p-T309,S474-AKT2:PIP3 phosphorylates PDE3B" xref: reactome:R-HSA-162657 "Inactivation of Myt1 kinase" xref: reactome:R-HSA-163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: reactome:R-HSA-1632857 "ULK1 phosphorylates AMBRA1:Beclin-1 complex" xref: reactome:R-HSA-163416 "hormone-sensitive lipase (HSL) + 2 ATP -> phosphorylated HSL + 2 ADP" xref: reactome:R-HSA-163418 "perilipin + 2 ATP -> phosphorylated perilipin + 2 ADP" xref: reactome:R-HSA-1638803 "Phosphorylation of cohesin by PLK1 at centromeres" xref: reactome:R-HSA-165162 "Phosphorylation of TSC2 by PKB" xref: reactome:R-HSA-165182 "Phosphorylation of complexed TSC2 by PKB" xref: reactome:R-HSA-166119 "First phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:Mal" xref: reactome:R-HSA-166245 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR complex" xref: reactome:R-HSA-166284 "Second phosphorylation of IRAK1 by IRAK4 bound to activated TLR:MyD88:TIRAP" xref: reactome:R-HSA-168053 "Phosphorylated MAPKs phosphorylate ATF-2" xref: reactome:R-HSA-168140 "Phospho-IKK Complex phosphorylates IkB within the IkB:NFkB Complex" xref: reactome:R-HSA-168184 "Activated TAK1 mediates phosphorylation of the IKK Complex" xref: reactome:R-HSA-170977 "FRS2 is phosphorylated by active TrkA receptor" xref: reactome:R-HSA-174119 "Free APC/C phosphorylated by Plk1" xref: reactome:R-HSA-174174 "Phosphorylation of the Emi1 DSGxxS degron by Plk1" xref: reactome:R-HSA-176116 "Recruitment and activation of Chk1" xref: reactome:R-HSA-176298 "Activation of claspin" xref: reactome:R-HSA-177692 "Activation of recruited TAK1 within the activated TLR3 complex" xref: reactome:R-HSA-187688 "p38 MAPK phosphorylates MAPKAPK2, MAPKAPK3" xref: reactome:R-HSA-193647 "IRAK is activated" xref: reactome:R-HSA-193703 "IKKbeta is activated" xref: reactome:R-HSA-193705 "IKKbeta phosphorylates IkB causing NF-kB to dissociate" xref: reactome:R-HSA-198270 "PDPK1 phosphorylates AKT at T308" xref: reactome:R-HSA-198347 "AKT phosphorylates BAD" xref: reactome:R-HSA-198371 "AKT phosphorylates GSK3" xref: reactome:R-HSA-198599 "AKT phosphorylates MDM2" xref: reactome:R-HSA-198609 "AKT phosphorylates TSC2, inhibiting it" xref: reactome:R-HSA-198611 "AKT phosphorylates IKKalpha" xref: reactome:R-HSA-198613 "AKT phosphorylates p21Cip1 and p27Kip1" xref: reactome:R-HSA-198621 "AKT phosphorylates caspase-9" xref: reactome:R-HSA-198640 "TORC2 (mTOR) phosphorylates AKT at S473" xref: reactome:R-HSA-198669 "p38MAPK phosphorylates MSK1" xref: reactome:R-HSA-198731 "ERK1/2 activates ELK1" xref: reactome:R-HSA-198746 "ERK1/2/5 activate RSK1/2/3" xref: reactome:R-HSA-198756 "ERK1/2 phosphorylates MSK1" xref: reactome:R-HSA-199298 "AKT phosphorylates CREB1" xref: reactome:R-HSA-199299 "AKT phosphorylates FOXO transcription factors" xref: reactome:R-HSA-199839 "AKT can phosphorylate RSK" xref: reactome:R-HSA-199863 "AKT can phosphorylate NR4A1 (NUR77)" xref: reactome:R-HSA-199895 "RSK1/2/3 phosphorylates CREB at Serine 133" xref: reactome:R-HSA-199910 "MSK1 activates ATF1" xref: reactome:R-HSA-199917 "MAPKAPK2 phosphorylates CREB at Serine 133" xref: reactome:R-HSA-199929 "ERK5 activates the transcription factor MEF2" xref: reactome:R-HSA-199935 "MSK1 activates CREB" xref: reactome:R-HSA-200143 "AKT phosphorylates AKT1S1 (PRAS40)" xref: reactome:R-HSA-200421 "Activation of cytosolic AMPK by phosphorylation" xref: reactome:R-HSA-201677 "Phosphorylation of LRP5/6 cytoplasmic domain by membrane-associated GSK3beta" xref: reactome:R-HSA-201691 "Phosphorylation of LRP5/6 cytoplasmic domain by CSNKI" xref: reactome:R-HSA-202222 "Phosphorylation of PKC theta" xref: reactome:R-HSA-202437 "Phosphorylation of CARMA1" xref: reactome:R-HSA-202459 "Phosphorylation of Bcl10" xref: reactome:R-HSA-202500 "Activation of IKK complex" xref: reactome:R-HSA-202510 "Activation of TAK1-TAB2 complex" xref: reactome:R-HSA-202541 "p-S177,S181-IKKB:IKKA:pUb-NEMO phosphorylates IkB-alpha:NF-kB" xref: reactome:R-HSA-2028284 "Phosphorylation of STK4 (MST1) and SAV1 by STK4" xref: reactome:R-HSA-2028555 "Phosphorylation of LATS1 and 2 by p-STK4 (p-MST1)" xref: reactome:R-HSA-2028583 "Phosphorylation of YAP by LATS2" xref: reactome:R-HSA-2028589 "Phosphorylation of LATS1 and 2 by p-STK3 (p-MST2)" xref: reactome:R-HSA-2028591 "Phosphorylation of STK3 (MST2) and SAV1 by STK3" xref: reactome:R-HSA-2028598 "Phosphorylation of YAP by LATS1" xref: reactome:R-HSA-2028629 "Phosphorylation of MOB1A and B by p-STK4 (p-MST1)" xref: reactome:R-HSA-2028635 "Phosphorylation of MOB1A and B by p-STK3 (p-MST2)" xref: reactome:R-HSA-2028661 "Phosphorylation of WWTR1 (TAZ) by LATS2" xref: reactome:R-HSA-2028670 "Phosphorylation of MOB1A and B by p-STK4(MST1)/N" xref: reactome:R-HSA-2028673 "Phosphorylation of LATS1 and 2 by p-STK3 (MST2)/N" xref: reactome:R-HSA-2028675 "Phosphorylation of MOB1A and B by p-STK3(MST2)/N" xref: reactome:R-HSA-2028679 "Phosphorylation of LATS1 and 2 by p-STK4(MST1)/N" xref: reactome:R-HSA-2029454 "Autophosphorylation of PAK1" xref: reactome:R-HSA-2029460 "PAK1 phosphorylates LIMK1" xref: reactome:R-HSA-2029469 "p-ERK phosphorylates WAVEs and ABI" xref: reactome:R-HSA-2060328 "Phosphorylation of WWTR1 (TAZ) by LATS1" xref: reactome:R-HSA-209087 "IKBA is phosphorylated by Phospho IKKB kinase" xref: reactome:R-HSA-211164 "AKT phosphorylates FOXO1A" xref: reactome:R-HSA-2168079 "MASTL (GWL) phosphorylates ARPP19" xref: reactome:R-HSA-2176475 "Phosphorylation of SMAD2 and SMAD3 linker regions by CDK8 or CDK9" xref: reactome:R-HSA-2243938 "AKT1 E17K mutant is phosphorylated by TORC2 complex" xref: reactome:R-HSA-2243942 "PDPK1 phosphorylates AKT1 E17K mutant" xref: reactome:R-HSA-2396007 "IRF3 is phosphorylated by TBK1" xref: reactome:R-HSA-2399941 "AKT1 E17K mutant phosphorylates BAD" xref: reactome:R-HSA-2399966 "AKT1 E17K mutant phosphorylates GSK3" xref: reactome:R-HSA-2399969 "AKT1 E17K mutant phosphorylates p21Cip1 and p27Kip1" xref: reactome:R-HSA-2399977 "AKT1 E17K mutant phosphorylates AKT1S1 (PRAS40)" xref: reactome:R-HSA-2399981 "AKT1 E17K mutant phosphorylates MDM2" xref: reactome:R-HSA-2399982 "AKT1 E17K mutant phosphorylates TSC2, inhibiting it" xref: reactome:R-HSA-2399985 "AKT1 E17K mutant phosphorylates caspase-9" xref: reactome:R-HSA-2399988 "AKT1 E17K mutant phosphorylates NR4A1 (NUR77)" xref: reactome:R-HSA-2399992 "AKT1 E17K mutant phosphorylates forkhead box transcription factors" xref: reactome:R-HSA-2399996 "AKT1 E17K mutant phosphorylates CREB1" xref: reactome:R-HSA-2399999 "AKT1 E17K mutant phosphorylates RSK" xref: reactome:R-HSA-2400001 "AKT1 E17K mutant phosphorylates CHUK (IKKalpha)" xref: reactome:R-HSA-2422927 "MAPK3-3 or MAPK1 phosphorylate GORASP2" xref: reactome:R-HSA-2430535 "MASTL phosphorylates ENSA" xref: reactome:R-HSA-2466068 "Phosphorylation of cohesin by PLK1 at chromosomal arms" xref: reactome:R-HSA-2470508 "ACVR2A/B (ActRIIA/B) phosphorylates ACVR1C (ActRIC, ALK7) in response to Activin" xref: reactome:R-HSA-2562526 "PLK1 phosphorylates OPTN" xref: reactome:R-HSA-2574840 "AJUBA facilitates AURKA autophosphorylation" xref: reactome:R-HSA-2730856 "Autophosphorylation of PAK" xref: reactome:R-HSA-2730863 "Phosphorylation of CARMA1 by PKC-theta" xref: reactome:R-HSA-2730868 "Phosphorylation of MEK7 by MEKK1" xref: reactome:R-HSA-2730876 "Phosphorylation of IKK-beta by TAK1" xref: reactome:R-HSA-2730896 "Phosphorylation of MEK4 by MEKK1" xref: reactome:R-HSA-2730900 "Activation of TAK1 complex bound to pUb-TRAF6" xref: reactome:R-HSA-2984226 "PLK1 phosphorylates NEK9" xref: reactome:R-HSA-2984258 "NEK9 phosphorylates NEK6/NEK7" xref: reactome:R-HSA-2990880 "NEK6/NEK7 phosphorylates NUP98" xref: reactome:R-HSA-2993898 "VRK1/VRK2 phosphorylate BANF1" xref: reactome:R-HSA-3000310 "AURKA phosphorylates PLK1" xref: reactome:R-HSA-3000327 "PLK1 phosphorylates BORA" xref: reactome:R-HSA-3132737 "MAPKs phosphorylate ETS1 and ETS2" xref: reactome:R-HSA-3209160 "Activated ERKs phosphorylate ERF" xref: reactome:R-HSA-3222006 "STK11 (LKB1) phosphorylates NUAK1" xref: reactome:R-HSA-3222020 "NUAK1 phosphorylates TP53" xref: reactome:R-HSA-3228469 "MAP3K5 phosphorylates MKK3 and MKK6" xref: reactome:R-HSA-3229102 "p-MAPKAPK3 phosphorylates BMI1" xref: reactome:R-HSA-3229152 "MAP3K5 (ASK1) phosphorylates MAP2K4 (SEK1)" xref: reactome:R-HSA-3239014 "MAPKAPK5 phosphorylates TP53" xref: reactome:R-HSA-3239019 "Active p38 MAPK phosphorylates MAPKAPK5" xref: reactome:R-HSA-3249371 "TBK1 phosphorylates STAT6 at Ser407" xref: reactome:R-HSA-3371435 "Constitutive phosphorylation by GSK3" xref: reactome:R-HSA-3371531 "Constitutive phosphorylation by pERK1/2" xref: reactome:R-HSA-3371567 "DBC1 is phosphorylated by ATM/ART" xref: reactome:R-HSA-349426 "Phosphorylation of MDM4 by CHEK2" xref: reactome:R-HSA-349444 "Phosphorylation of COP1 at Ser-387 by ATM" xref: reactome:R-HSA-349455 "Phosphorylation of MDM4 by ATM" xref: reactome:R-HSA-3656517 "TGFBR2 phosphorylates TGFBR1 KD Mutants" xref: reactome:R-HSA-374696 "Phosphorylation of L1 by p90rsk" xref: reactome:R-HSA-3769394 "AKT phosphorylates CBY1" xref: reactome:R-HSA-377186 "Activated Akt1 phosphorylates AKT1S1 (PRAS40)" xref: reactome:R-HSA-3772435 "WNT signaling stimulates CSNK1-dependent phosphorylation of DVL" xref: reactome:R-HSA-380272 "Plk1-mediated phosphorylation of Nlp" xref: reactome:R-HSA-381091 "IRE1 dimer autophosphorylates" xref: reactome:R-HSA-381111 "Phosphorylation of eIF2-alpha by PERK" xref: reactome:R-HSA-3857328 "RPS6KA1/2/3 phosphorylates CEBPB on S321" xref: reactome:R-HSA-3857329 "MAPK3 (ERK1) and MAPK1 (ERK2) phosphorylate CEBPB" xref: reactome:R-HSA-3858480 "WNT-dependent phosphorylation of DVL" xref: reactome:R-HSA-389756 "AKT interacts and phosphorylates Cot" xref: reactome:R-HSA-3928577 "ROCK phosphorylates LIMK1,2" xref: reactome:R-HSA-3928608 "LIMK phosphorylates CFL1, inactivating it" xref: reactome:R-HSA-3928616 "Activated ROCK phosphorylates MRLCs" xref: reactome:R-HSA-3928620 "PAK1 autophosphorylates" xref: reactome:R-HSA-3928625 "PAKs autophosphorylate" xref: reactome:R-HSA-3928640 "PAKs phosphorylate MLC" xref: reactome:R-HSA-399939 "Autophosphorylation of PAK" xref: reactome:R-HSA-399944 "Phosphorylation of CRMPs by Cdk5" xref: reactome:R-HSA-399950 "Phosphorylation of cofilin by LIMK-1" xref: reactome:R-HSA-399951 "Phosphorylation of CRMPs by GSK3beta" xref: reactome:R-HSA-399952 "Phosphorylation of LIMK-1 by PAK" xref: reactome:R-HSA-399978 "Protein kinase C, alpha type phosphorylates MARCKS" xref: reactome:R-HSA-400382 "CSNK1E,CSNK1D phosphorylate CRY and PER proteins" xref: reactome:R-HSA-4088134 "PLK1 phosphorylates FOXM1" xref: reactome:R-HSA-419083 "Myosin phosphatase inactivation by ROCK" xref: reactome:R-HSA-419087 "LIM kinase phosphorylation by ROCK" xref: reactome:R-HSA-419197 "Myosin regulatory light chain phosphorylation by ROCK" xref: reactome:R-HSA-419644 "Transphosphorylation of pLIMK1" xref: reactome:R-HSA-428961 "Phosphorylation of cPLA2 by MAPK p38 alpha" xref: reactome:R-HSA-429016 "ALOX5 is phosphorylated by MAPKAP2" xref: reactome:R-HSA-429698 "PRKD1,2,3 phosphorylates COL4A3BP-2" xref: reactome:R-HSA-429714 "monophospho-CERT + 2 ATP => multiphospho-CERT + 2 ADP" xref: reactome:R-HSA-432110 "Integrin alpha IIb beta3 T779 phosphorylation blocks SHC binding" xref: reactome:R-HSA-4332358 "Dissociation of CaM and CAMK2 autophosphorylation" xref: reactome:R-HSA-4332363 "Autophosphorylation and activation of CAMK2" xref: reactome:R-HSA-4332388 "Activation of MAP3K7 in response to WNT" xref: reactome:R-HSA-4411383 "NLK phosphorylates TCF/LEF" xref: reactome:R-HSA-4411402 "Activation of NLK" xref: reactome:R-HSA-442739 "PDPK1 phosphorylates RSKs" xref: reactome:R-HSA-442832 "PAK phosphorylates cortactin" xref: reactome:R-HSA-445072 "Interaction of PAK1 with Rac1-GTP" xref: reactome:R-HSA-446694 "IRAK4 phosphorylates IRAK1" xref: reactome:R-HSA-446701 "IRAK4-activated IRAK1 autophosphorylates" xref: reactome:R-HSA-448948 "Phosphorylation of E proteins by p38 MAPK" xref: reactome:R-HSA-448955 "Phosphorylation of MEF2 proteins by p38" xref: reactome:R-HSA-450222 "Active p38 MAPK phosphorylates MAPKAPK2 or 3" xref: reactome:R-HSA-450325 "c-FOS activation by phospho ERK1/2" xref: reactome:R-HSA-450337 "Activated TAK1 phosphorylates MKK4/MKK7" xref: reactome:R-HSA-450346 "activated human TAK1 phosphorylates MKK3/MKK6" xref: reactome:R-HSA-450463 "MK2 phosphorylates ZFP36 (Tristetraproline, TTP)" xref: reactome:R-HSA-450474 "MK2 phosphorylates BRF1" xref: reactome:R-HSA-450490 "Protein Kinase B/Akt phosphorylates BRF1" xref: reactome:R-HSA-450499 "Protein Kinase B (AKT) phosphorylates KSRP" xref: reactome:R-HSA-450533 "PKCdelta phosphorylates HuR" xref: reactome:R-HSA-450550 "PKCalpha phosphorylates HuR" xref: reactome:R-HSA-450827 "hp-IRAK1, hp-IRAK4 4 phosphorylate Pellino-1 and 2." xref: reactome:R-HSA-451152 "MAP kinase p38 phosphorylates KSRP" xref: reactome:R-HSA-451347 "Activation of JNK by DSCAM" xref: reactome:R-HSA-4551570 "VANGL2 is phosphorylated in response to WNT5A" xref: reactome:R-HSA-4608825 "DVL2 is phosphorylated after WNT5A binding to FZD" xref: reactome:R-HSA-4793911 "MAPKAPK2 phosphorylates HSF1" xref: reactome:R-HSA-5082387 "Phosphorylation of HSF1 at Ser230 induces transactivation" xref: reactome:R-HSA-5082405 "Phosphorylation of HSF1 at Ser326 induces transactivation" xref: reactome:R-HSA-5213464 "RIPK1 is phosphorylated" xref: reactome:R-HSA-5213466 "RIPK3 is phosphorylated" xref: reactome:R-HSA-5218814 "PAK2 autophorylates" xref: reactome:R-HSA-5218821 "PDK1 phosphorylates PKC" xref: reactome:R-HSA-5218823 "PKC phosphorylates sphingosine kinase 1" xref: reactome:R-HSA-5218826 "Active ROCK1,ROCK2 phosphorylates p-5Y-PTK2 on S732" xref: reactome:R-HSA-5218854 "p-Y420-FYN is phosphorylated on S21" xref: reactome:R-HSA-5218906 "RIPK3 phosphorylates MLKL" xref: reactome:R-HSA-5218916 "p-MAPK2/3 phosphorylates HSP27" xref: reactome:R-HSA-5228811 "IkBA variant is not phosphorylated within IkBA:NF-kappaB" xref: reactome:R-HSA-5229194 "Depolymerization of lamin filaments after PKC-mediated phosphorylation" xref: reactome:R-HSA-5229343 "AXIN is phosphorylated in the destruction complex" xref: reactome:R-HSA-5260201 "p-AKT2 phosphorylates C2CD5" xref: reactome:R-HSA-5357472 "PAK1-3 autophosphorylates" xref: reactome:R-HSA-5357477 "PAK1-3 phosphorylates VE-cadherin" xref: reactome:R-HSA-5357831 "CYLD is phosphorylated by IKK" xref: reactome:R-HSA-5578777 "DMPK phosphorylates PLN" xref: reactome:R-HSA-5607722 "Active NIK phosphorylates IKKA dimer" xref: reactome:R-HSA-5607732 "K63polyUb-TAK1 autophosphorylates" xref: reactome:R-HSA-5607742 "K63polyUb-p-3T,1S-TAK1 phosphorylates IKK-beta" xref: reactome:R-HSA-5610718 "CK1 phosphorylates p-GLI2" xref: reactome:R-HSA-5610722 "CK1 phosphorylates p-GLI3" xref: reactome:R-HSA-5610730 "GSK3 phosphorylates p-GLI2" xref: reactome:R-HSA-5610732 "GSK3 phosphorylates p-GLI3" xref: reactome:R-HSA-5623667 "PDPK1 phosphorylates PKN1,2,3" xref: reactome:R-HSA-5624473 "Protein kinase A (PKA) and RPS6KA5 (MSK1) phosphorylates p65 (RELA) subunit" xref: reactome:R-HSA-5624492 "PAK phosphorylates p21 RAF1 on S338" xref: reactome:R-HSA-5625784 "PKN1 phosphorylates histone 3 of nucleosomes associate with KLK2 and KLK3 promoters" xref: reactome:R-HSA-5627775 "Autophosphorylation of PAK1,2,3" xref: reactome:R-HSA-5632670 "CSNK1A1 phosphorylates SMO dimer" xref: reactome:R-HSA-5632672 "ADRBK1 phosphorylates SMO dimer" xref: reactome:R-HSA-5635841 "GLI proteins are phosphorylated" xref: reactome:R-HSA-5635842 "ULK3 phosphorylates GLI" xref: reactome:R-HSA-5665868 "AMPK (complex) phosphorylates ULK1 (complex)" xref: reactome:R-HSA-5666160 "AURKB phosphorylates DIAPH2-2 at kinetochores" xref: reactome:R-HSA-5668932 "PAK2 phosphorylates myosin regulatory light chain (MRLC)" xref: reactome:R-HSA-5668947 "PAK1 phosphorylates myosin phosphatase" xref: reactome:R-HSA-5668984 "PAK1 or PAK2 phosphorylates MYLK" xref: reactome:R-HSA-5669250 "PAK1 phosphorylates FLNA" xref: reactome:R-HSA-5671749 "p-T774-PKN1 phosphorylates CDC25C" xref: reactome:R-HSA-5671763 "p-T774-PKN1 phosphorylates PPP1R14A" xref: reactome:R-HSA-5671919 "Activated CIT phosphorylates MRLCs" xref: reactome:R-HSA-5672008 "Thr-180 of ULK1 is phosphorylated" xref: reactome:R-HSA-5672010 "Active mTORC1 phosphorylates ULK1" xref: reactome:R-HSA-5672828 "mTORC1 phosphorylates AKT1S1" xref: reactome:R-HSA-5672948 "MARK3 phosphorylates KSR1" xref: reactome:R-HSA-5672973 "MAP2Ks phosphorylate MAPKs" xref: reactome:R-HSA-5672978 "RAF phosphorylates MAP2K dimer" xref: reactome:R-HSA-5674496 "Activated MAPKs phosphorylate MAP2K1" xref: reactome:R-HSA-5675194 "Activated MAPK phosphorylates RAF1" xref: reactome:R-HSA-5675198 "Activated MAPKs phosphorylate BRAF" xref: reactome:R-HSA-5675868 "ULK1 phosphorylates ATG13 and RB1CC1" xref: reactome:R-HSA-5679205 "ULK1 phosphorylates Beclin-1" xref: reactome:R-HSA-5682026 "MRN bound to shortened telomeres activates ATM" xref: reactome:R-HSA-5682101 "PKA phosphorylates 4xPALM-C-p-2S-ABCA1 tetramer" xref: reactome:R-HSA-5682598 "ATM phosphorylates HERC2" xref: reactome:R-HSA-5682983 "ATM phosphorylates WHSC1" xref: reactome:R-HSA-5683425 "ATM phosphorylates TP53BP1 at DNA DSBs" xref: reactome:R-HSA-5683792 "p-T68-CHEK2 autophosphorylates" xref: reactome:R-HSA-5683801 "CHEK2 phosphorylates BRCA1" xref: reactome:R-HSA-5683964 "ATM phosphorylates EYA1-4" xref: reactome:R-HSA-5684096 "CDK2 phosphorylates RBBP8" xref: reactome:R-HSA-5684140 "ATM phosphorylates RBBP8" xref: reactome:R-HSA-5684887 "Activation of CHEK1 at resected DNA DSBs" xref: reactome:R-HSA-5685156 "ATR phosphorylates RPA2" xref: reactome:R-HSA-5685230 "CHEK1 phosphorylates RAD51" xref: reactome:R-HSA-5685242 "CHEK1 phosphorylates BRCA2" xref: reactome:R-HSA-5686578 "Activated ATM phosphorylates ABL1" xref: reactome:R-HSA-5686704 "Activated ATM phosphorylates DCLRE1C" xref: reactome:R-HSA-5687086 "PAK1,2,3 phosphorylates MAPK6,4" xref: reactome:R-HSA-5687090 "p-S MAPK6 phosphorylates NCOA3" xref: reactome:R-HSA-5687094 "p-S MAPK6,4 phosphorylate MAPKAPK5" xref: reactome:R-HSA-5687101 "p-T182 MAPKAPK5 phosphorylates FOXO3" xref: reactome:R-HSA-5687121 "p-S MAPKAPK5 phosphorylates HSPB1" xref: reactome:R-HSA-5687183 "PRKDC phosphorylates DCLRE1C at DNA DSBs" xref: reactome:R-HSA-5690250 "p-T182-MAPKAPK5 phoshphorylates DNAJB1" xref: reactome:R-HSA-5692768 "MAPKAPK5 phosphorylates KALRN" xref: reactome:R-HSA-5692775 "SEPT7:p-S189 MAPK6:p-T182 MAPKAPK5 phosphorylates CDC42EPs" xref: reactome:R-HSA-5692779 "p-S182 MAPKAPK5 phosphorylates FOXO1" xref: reactome:R-HSA-5693536 "ATM phosphorylates MDC1" xref: reactome:R-HSA-5693540 "MRN activates ATM" xref: reactome:R-HSA-5693549 "ATM phosphorylates histone H2AFX on S139 at DNA DSBs" xref: reactome:R-HSA-5693551 "Phosphorylation of BRCA1-A complex at multiple sites by ATM" xref: reactome:R-HSA-5693575 "DNA-PKcs autophosphorylates" xref: reactome:R-HSA-5693598 "ATM phosphorylates NBN" xref: reactome:R-HSA-5693609 "ATM phosphorylates TP53 at S15" xref: reactome:R-HSA-5694441 "CSNK1D phosphorylates SEC23" xref: reactome:R-HSA-6788392 "ATR phosphorylates RPA2, FANCI, FANCD2 and FANCM at ICL-DNA" xref: reactome:R-HSA-6795290 "TORC2 complex phosphorylates SGK1" xref: reactome:R-HSA-6795460 "SGK1 phosphorylates MDM2" xref: reactome:R-HSA-6795473 "PDPK1 phosphorylates SGK1" xref: reactome:R-HSA-6798372 "ATM phosphorylates DYRK2" xref: reactome:R-HSA-6798374 "DYRK2 phosphorylates TP53" xref: reactome:R-HSA-6799097 "ATM phosphorylates ZNF420" xref: reactome:R-HSA-6799246 "CHEK1 phosphorylates TP53" xref: reactome:R-HSA-6799332 "ATR phosphorylates TP53" xref: reactome:R-HSA-6799409 "HIPK2 phosphorylates TP53" xref: reactome:R-HSA-6800490 "ATM phosphorylates PIDD1" xref: reactome:R-HSA-6801666 "PLK2 phosphorylates CENPJ" xref: reactome:R-HSA-6801675 "PLK2 phosphorylates NPM1" xref: reactome:R-HSA-6802911 "High kinase activity BRAF complexes phosphorylate MAP2Ks" xref: reactome:R-HSA-6802919 "RAS:GTP:moderate kinase activity p-RAF complexes phosphorylate MAP2Ks" xref: reactome:R-HSA-6802926 "Mutant RAS:p-RAF complexes phosphorylate MAP2Ks" xref: reactome:R-HSA-6802933 "p-BRAF and RAF fusion dimers phosphorylate MAP2Ks" xref: reactome:R-HSA-6802935 "MAPKs are phosphorylated downstream of BRAF and RAF fusion dimers" xref: reactome:R-HSA-6802943 "RAS:GTP:inactive p-RAF complexes phosphorylate MAP2Ks" xref: reactome:R-HSA-6802973 "PLK3 phosphorylates CDC25C" xref: reactome:R-HSA-6804266 "CHEK2 phosphorylates TTC5" xref: reactome:R-HSA-6804276 "ATM phosphorylates TTC5" xref: reactome:R-HSA-6804955 "ATM phosphorylates MDM2" xref: reactome:R-HSA-6805059 "CK2:FACT phosphorylates TP53" xref: reactome:R-HSA-6805103 "AURKA phosphorylates TP53" xref: reactome:R-HSA-6805126 "AURKB phosphorylates TP53" xref: reactome:R-HSA-6805276 "CDK5 phosphorylates TP53" xref: reactome:R-HSA-6805285 "PLK3 phosphorylates TP53" xref: reactome:R-HSA-6805399 "TAF1 phosphorylates TP53" xref: reactome:R-HSA-6805479 "TP53RK phosphorylates TP53" xref: reactome:R-HSA-6805640 "AKT phosphorylates KAT6A" xref: reactome:R-HSA-6805785 "AKT phosphorylates PHF20" xref: reactome:R-HSA-6810233 "CDK7 phosphorylates serine-5 and serine-7 of heptad repeats in C-terminal domain of RNA polymerase II at snRNA promoter" xref: reactome:R-HSA-6811454 "MAPKs phosphorylate PP2A" xref: reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: reactome:R-HSA-69608 "Phosphorylation of Cdc25A at Ser-123 by Chk2" xref: reactome:R-HSA-69685 "CHEK2 phosphorylates TP53" xref: reactome:R-HSA-69889 "Phosphorylation and activation of Chk1 by ATM" xref: reactome:R-HSA-69891 "Phosphorylation and activation of CHEK2 by ATM" xref: reactome:R-HSA-75010 "Phosphorylation of Cdc25C at Ser 216 by Chk1" xref: reactome:R-HSA-75820 "Phosphorylation of Cyclin D1 at T286 by glycogen synthase kinase-3 beta" xref: reactome:R-HSA-8850945 "Casein kinase II phosphorylates PTEN" xref: reactome:R-HSA-8852306 "Mitotic phosphorylation-induced dissociation of GTSE1 from microtubule plus ends" xref: reactome:R-HSA-8852317 "PLK1 phosphorylates GTSE1" xref: reactome:R-HSA-8853419 "TPX2 promotes AURKA autophosphorylation" xref: reactome:R-HSA-8853444 "AURKA phosphorylates PHLDA1" xref: reactome:R-HSA-8854908 "PKA phosphorylates RET:GDNF:GFRA dimer" xref: reactome:R-HSA-8856813 "AAK1 phosphorylates AP-2 mu subunit at T156" xref: reactome:R-HSA-8863007 "p25-bound CDK5 phosphorylates CDC25B" xref: reactome:R-HSA-8863011 "p25-bound CDK5 phosphorylates CDC25C" xref: reactome:R-HSA-8863014 "p25-bound CDK5 phosphorylates CDC25A" xref: reactome:R-HSA-8863895 "IKKB phosphorylates SNAP23" xref: reactome:R-HSA-8868260 "CDK5:p25 phosphorylates GOLGA2" xref: reactome:R-HSA-8868340 "CDK5:p25 phosphorylates lamin B1" xref: reactome:R-HSA-8868344 "CDK5:p25 phosphorylates lamin A" xref: reactome:R-HSA-8868567 "CDK5:p25 phosphorylates PRDX1" xref: reactome:R-HSA-8868573 "CDK5:p25 phosphorylates PRDX2" xref: reactome:R-HSA-8868666 "CDK5:p25 phosphorylates JUN" xref: reactome:R-HSA-8870558 "CDK5:p25 phosphorylates FOXO3" xref: reactome:R-HSA-8873929 "Casein kinase II phosphorylates STARD10" xref: reactome:R-HSA-8876446 "p-ULK1 phosphorylates DENND3" xref: reactome:R-HSA-8877691 "MAP2K6 phosphorylates PIP4K2B" xref: reactome:R-HSA-8878050 "HIPK2 phosphorylates RUNX1 and EP300" xref: reactome:R-HSA-8878054 "HIPK2 phosphorylates RUNX1" xref: reactome:R-HSA-8933446 "Active AKT phosphorylates DENND1A and DENND1B in response to insulin signaling" xref: reactome:R-HSA-8934446 "Activated PKC phosphorylates SHC1" xref: reactome:R-HSA-8939963 "Activated AKT phosphorylates RUNX2" xref: reactome:R-HSA-8940100 "CDK1 phosphorylates VCPIP1" xref: reactome:R-HSA-8944454 "mTORC1 phosphorylates MAF1" xref: reactome:R-HSA-8948757 "AKT phosphorylates MKRN1" xref: reactome:R-HSA-8952289 "FAM20C phosphorylates FAM20C substrates" xref: reactome:R-HSA-9007539 "CHEK1 phosphorylates E2F6" xref: reactome:R-HSA-9008480 "GSK3B phosphorylates RUNX2" xref: reactome:R-HSA-9008822 "PPM1D dephosphorylates RUNX2" xref: reactome:R-HSA-9009208 "Activated ERKs phosphorylate RUNX2" xref: reactome:R-HSA-9010681 "PKC phosphorylates ROBO3.1" xref: reactome:R-HSA-9012319 "p-TEFb phosphorylates serine 2 in RNA polymerase II CTD" xref: reactome:R-HSA-9013978 "Phosphorylation of IRF-3/IRF7 and their release from the activated TLR3 complex" xref: reactome:R-HSA-9021357 "PRKCI phosphorylates ELF3" xref: reactome:R-HSA-9022314 "HIPK2 phosphorylates MECP2" xref: reactome:R-HSA-9023132 "AURKB phosphorylates MECP2 at S423" xref: reactome:R-HSA-9032751 "Estrogen-independent phosphorylation of ESR1 S118 by MAPK1 and MAPK3" xref: reactome:R-HSA-9032863 "CDK5 phosphorylates NTRK2" xref: reactome:R-HSA-909552 "Phosphorylation of STAT1 at Ser727" xref: reactome:R-HSA-912470 "ATR phosphorylates Histone H2A.X at unsynapsed regions" xref: reactome:R-HSA-913996 "PKA/PKG phosphorylate Rap1GAP2" xref: reactome:R-HSA-927889 "SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex)" xref: reactome:R-HSA-934559 "SPRY2 is phosphorylated by phosphorylated MNK1" xref: reactome:R-HSA-936951 "Activation of TAK1 complex bound to activated TLR4 complex" xref: reactome:R-HSA-936991 "Auto phosphorylation of TAK1 bound to p-IRAK2:pUb oligo-TRAF6: free K63 pUb:TAB1:TAB2/TAB3" xref: reactome:R-HSA-937022 "IRAK4 autophosphorylation in the complex with activated TLR:MyD88:TIRAP" xref: reactome:R-HSA-9604328 "AKT1 phosphorylates NOTCH4" xref: reactome:R-HSA-9612980 "BRAF in Rap1-GTP complex:BRAF complex autophosphorylates" xref: reactome:R-HSA-9619515 "AMPK phosphorylates MAPT" xref: reactome:R-HSA-9619843 "ERKs phosphorylate RSKs" xref: reactome:R-HSA-9620004 "RSKs autophosphorylate" xref: reactome:R-HSA-9626880 "MAPK11 or MAPK14 phosphorylates NCF1 at Ser345" xref: reactome:R-HSA-9627089 "CASP9 is phosphorylated at T125" xref: reactome:R-HSA-975125 "Multiple IRAK1 autophosphorylation steps within the complex pIRAK4:MyD88:activated TLR7/8 or 9" xref: reactome:R-HSA-975134 "Second phosphorylation of IRAK1 by IRAK4 bound to MyD88: activated TLR 7/8 or 9" xref: reactome:R-HSA-975160 "Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomer:activated TLR 7/8 or 9" xref: reactome:R-HSA-975170 "IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9" xref: reactome:R-HSA-975180 "First phosphorylation of IRAK1 by IRAK4 bound to MyD88:activated TLR 7/8 or 9" xref: reactome:R-HSA-975865 "IRAK4 autophosphorylation within the complex activated TLR:MyD88" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004675 name: transmembrane receptor protein serine/threonine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.30] synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "STK13" RELATED [EC:2.7.11.30] synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] xref: EC:2.7.11 xref: MetaCyc:2.7.11.30-RXN xref: reactome:R-HSA-170868 "Activated type I receptor phosphorylates SMAD2/3 directly" xref: reactome:R-HSA-198732 "STAT3 activation" xref: reactome:R-HSA-201476 "Activated type I receptor phosphorylates R-Smad1/5/8 directly" xref: reactome:R-HSA-3702184 "Activated type I receptor phosphorylates SMAD2/3 MH2 domain mutants directly" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004676 name: 3-phosphoinositide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a phosphatidylinositol-3-phosphate." [GOC:mah] synonym: "PDK activity" RELATED [PMID:10075713] synonym: "phosphatidylinositol-3-phosphate protein kinase activity" EXACT [GOC:curators] xref: EC:2.7.11 xref: reactome:R-HSA-437195 "PDK1 activates PKC zeta" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004677 name: DNA-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of DNA." [GOC:mah] xref: EC:2.7.11 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004679 name: AMP-activated protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of AMP." [GOC:mah] synonym: "5'-AMP-activated protein kinase activity" EXACT [] synonym: "AMPK activity" RELATED [GOC:mah] synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] xref: EC:2.7.11 xref: reactome:R-HSA-1592244 "AMPK phosphorylates PPARGC1A" xref: reactome:R-HSA-163691 "Phosphorylation of ChREBP at Serine 568 by AMPK" xref: reactome:R-HSA-200423 "pAMPK inactivates ACACB, inhibiting malonyl-CoA synthesis" xref: reactome:R-HSA-380927 "p-AMPK phosphorylates TSC1:TSC2" xref: reactome:R-HSA-447074 "AMPK phosphorylates Raptor in the mTORC1 complex" xref: reactome:R-HSA-5673768 "p-AMPK:AMP phosphorylates Raptor in the mTORC1 complex" xref: reactome:R-HSA-6805470 "AMPK phosphorylates TP53" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0004680 name: obsolete casein kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase activity" EXACT [] xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004681 name: obsolete casein kinase I activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase I activity" EXACT [] xref: EC:2.7.11 is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004682 name: obsolete protein kinase CK2 activity namespace: molecular_function alt_id: GO:0008604 def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase II activity" RELATED [] synonym: "casein kinase II, catalytic activity" EXACT [] synonym: "protein kinase CK2 activity" EXACT [] synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004683 name: calmodulin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0004684 alt_id: GO:0004685 alt_id: GO:0004688 def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions require the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] synonym: "calmodulin regulated protein kinase activity" EXACT [] synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] synonym: "calmodulin-dependent protein kinase I activity" NARROW [] synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] synonym: "CAM PKII" RELATED [EC:2.7.11.17] synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] synonym: "CaMKI" RELATED [EC:2.7.11.17] synonym: "CaMKII" RELATED [EC:2.7.11.17] synonym: "CaMKIV" RELATED [EC:2.7.11.17] synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] synonym: "STK20" RELATED [EC:2.7.11.17] xref: EC:2.7.11.17 xref: MetaCyc:2.7.11.17-RXN xref: reactome:R-HSA-111912 "CaMK4 phosphorylates CREB1" xref: reactome:R-HSA-111915 "CAMK4 autophosphorylates" xref: reactome:R-HSA-416320 "Trafficking of GluR1-containing AMPA receptors" xref: reactome:R-HSA-442749 "CaMKK autophosphorylates in the nucleus" xref: reactome:R-HSA-9006992 "MECP2 is phosphorylated at S423" xref: reactome:R-HSA-9617583 "CaMKII autophosphorylates" xref: reactome:R-HSA-9618750 "CaMKII phosphorylates AMPA receptor" xref: reactome:R-HSA-9619125 "CaMKK phosphorylates CAMK4" xref: reactome:R-HSA-9619355 "CaMKK autophosphorylates in the cytosol" xref: reactome:R-HSA-9619367 "CaMKKs phosphorylate CAMK1" xref: reactome:R-HSA-9619478 "CAMKK2 phosphorylates AMPK" xref: reactome:R-HSA-9619783 "CAMK1 phosphorylates ARHGEF7-1" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004686 name: elongation factor-2 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [elongation factor 2] = ADP + [elongation factor 2] phosphate." [EC:2.7.11.20, MetaCyc:2.7.11.20-RXN] synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] synonym: "eEF-2 kinase activity" EXACT [] synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eEF2K" RELATED [EC:2.7.11.20] synonym: "EF2K" RELATED [EC:2.7.11.20] synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 xref: MetaCyc:2.7.11.20-RXN is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004687 name: myosin light chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-light-chain = ADP + myosin-light-chain phosphate." [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] synonym: "MLCK" RELATED [EC:2.7.11.18] synonym: "MLCkase activity" EXACT [EC:2.7.11.18] synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin-light-chain kinase activity" EXACT [] synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] synonym: "STK18" RELATED [EC:2.7.11.18] xref: EC:2.7.11.18 xref: MetaCyc:2.7.11.18-RXN xref: reactome:R-HSA-445813 "Phosphorylation of Smooth Muscle Myosin Light Chains" xref: reactome:R-HSA-5668978 "MYLK (MLCK) phosphorylates MRLCs of the non-muscle myosin II complex" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004689 name: phosphorylase kinase activity namespace: molecular_function alt_id: GO:0008606 def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "PHK" RELATED [EC:2.7.11.19] synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] synonym: "STK17" RELATED [EC:2.7.11.19] xref: EC:2.7.11.19 xref: MetaCyc:2.7.11.19-RXN xref: reactome:R-HSA-453337 "glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP" xref: reactome:R-HSA-71541 "glycogen phosphorylase (PYGM) dimer b + 2 ATP => glycogen phosphorylase (PYGM) dimer a + 2 ADP" xref: reactome:R-HSA-71588 "glycogen phosphorylase (PYGL) dimer b + 2 ATP => glycogen phosphorylase (PYGL) dimer a + 2 ADP" is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004690 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of a cyclic nucleotide." [GOC:mah] xref: EC:2.7.11 is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0004691 name: cAMP-dependent protein kinase activity namespace: molecular_function alt_id: GO:0008602 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: MetaCyc:2.7.11.11-RXN xref: reactome:R-HSA-163672 "Phosphorylation of ChREBP at Thr(666) by PKA" xref: reactome:R-HSA-163676 "Phosphorylation of pChREBP (Thr 666) at Ser(196) by PKA" xref: reactome:R-HSA-163773 "Phosphorylation of PF2K-Pase by PKA catalytic subunit" xref: reactome:R-HSA-177275 "PKA phosphorylates DARPP-32 on Thr34" xref: reactome:R-HSA-177284 "PKA phosphorylates PDE4B" xref: reactome:R-HSA-432232 "Phosphorylation of Aquaporin-2 by Protein Kinase A (PKA)" xref: reactome:R-HSA-5610717 "PKA phosphorylates GLI2" xref: reactome:R-HSA-5610720 "PKA phosphorylates GLI3" xref: reactome:R-HSA-5610741 "PKA phosphorylates GLI1" xref: reactome:R-HSA-5617179 "PRKACA phosphorylates TNNI3" xref: reactome:R-HSA-5617182 "PRKACA phosphorylates PLN" xref: reactome:R-HSA-5687088 "PKA phosphorylates MAPKAPK5" xref: reactome:R-HSA-913451 "IL3RB is phosphorylated on Ser-585" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004692 name: cGMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires the presence of cGMP." [GOC:mah] synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "PKG" RELATED [EC:2.7.11.12] synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] synonym: "PKG 1beta" RELATED [EC:2.7.11.12] synonym: "PKG II" RELATED [EC:2.7.11.12] synonym: "STK23" RELATED [EC:2.7.11.12] xref: EC:2.7.11.12 xref: MetaCyc:2.7.11.12-RXN xref: reactome:R-HSA-1475422 "PTPS is phosphorylated by cGMP-dependant protein kinase II" xref: reactome:R-HSA-1497853 "Sepiapterin reductase (SPR) is phosphorylated by Ca2+/calmodulin-dependent protein kinase II" xref: reactome:R-HSA-418442 "PKG1 phosphorylates IRAG:IP3R1 inhibiting IP3-stimulated Ca2+ release" xref: reactome:R-HSA-418549 "PKG1 phosphorylates BK channels" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004693 name: cyclin-dependent protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0016537 def: "Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. This reaction requires the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:pr, GOC:rn, PMID:7877684, PMID:9841670] synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] synonym: "CDK" RELATED [EC:2.7.11.22] synonym: "CDK activity" EXACT [] synonym: "CDK, catalytic subunit activity" EXACT [] synonym: "cdk-activating kinase activity" RELATED [EC:2.7.11.22] synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent protein kinase activity" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] xref: EC:2.7.11.22 xref: MetaCyc:2.7.11.22-RXN xref: reactome:R-HSA-1226094 "Cyclin D:Cdk4/6 mediated phosphorylation of p130 (RBL2) and dissociation of phosphorylated p130 (RBL2) from DP1:E2F4/5 complex" xref: reactome:R-HSA-1226095 "Cyclin D:CDK4/6 mediated phosphorylation of p107 (RBL1) and dissociation of phosphorylated p107 (p-RBL1) from DP1:E2F4 complex" xref: reactome:R-HSA-174079 "Phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: reactome:R-HSA-174122 "Phosphorylation of the Emi1 DSGxxS degron by Cyclin B:Cdc2" xref: reactome:R-HSA-174132 "Free APC/C phosphorylated by Cyclin B:Cdc2" xref: reactome:R-HSA-174251 "Phosphorylation of Cdh1 by Cyclin B1:Cdc2" xref: reactome:R-HSA-180047 "CDK5 phosphorylates DARPP-32 on Thr75" xref: reactome:R-HSA-187520 "Cyclin E/A:Cdk2-mediated phosphorylation of p27/p21" xref: reactome:R-HSA-187916 "Cyclin A:Cdk2 mediated phosphorylation of p27/p21" xref: reactome:R-HSA-187948 "Phosphorylation of proteins involved in the G1/S transition by Cyclin A:Cdk2" xref: reactome:R-HSA-187959 "Phosphorylation of E2F1/E2F3 by Cyclin A:phosph-Cdk2(Thr 160)" xref: reactome:R-HSA-188390 "Cyclin E:Cdk2-mediated phosphorylation of Rb" xref: reactome:R-HSA-1912391 "NICD1 is phosphorylated by CDK8" xref: reactome:R-HSA-2172183 "Phosphorylation of GORASP1, GOLGA2 and RAB1A by CDK1:CCNB" xref: reactome:R-HSA-2220971 "CDK8 phosphorylates NICD1 PEST domain mutants" xref: reactome:R-HSA-2245218 "CDK1 phosphorylates PHF8" xref: reactome:R-HSA-2294600 "CDK1 phosphorylates condensin II subunit NCAPD3" xref: reactome:R-HSA-2430533 "CDK1 phosphorylates MASTL" xref: reactome:R-HSA-2468287 "CDK1 phosphorylates CDCA5 (Sororin) at centromeres" xref: reactome:R-HSA-2468293 "CDK1 phosphorylates CDCA5 (Sororin) at chromosomal arms" xref: reactome:R-HSA-2514854 "CDK1 phosphorylates condensin I" xref: reactome:R-HSA-2984220 "CDK1:CCNB phosphorylates NEK9" xref: reactome:R-HSA-2990882 "CDK1 phosphorylates NUP98" xref: reactome:R-HSA-3788705 "CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2" xref: reactome:R-HSA-380278 "CCNB1:p-T160-CDK1 phosphorylates NUMA1" xref: reactome:R-HSA-4086410 "CDK1 phosphorylates BORA" xref: reactome:R-HSA-4088024 "CCNA:CDK1/2 complexes and CCNB1:CDK1 complexes phosphorylate FOXM1" xref: reactome:R-HSA-5195402 "CDK1 phosphorylates LPIN" xref: reactome:R-HSA-5244669 "CDK1 phosphorylates lamins and facilitates depolymerization of lamin filaments" xref: reactome:R-HSA-5692755 "CDK1 phosphorylates MAPK6" xref: reactome:R-HSA-6793661 "(CDK1,CDK2):CCNA phosphorylates MDM2 at T218" xref: reactome:R-HSA-6797606 "CDK12 phosphorylates RNA Pol II CTD at DNA repair genes" xref: reactome:R-HSA-6805109 "CDK2 phosphorylates TP53" xref: reactome:R-HSA-68944 "Orc1 is phosphorylated by cyclin A/CDK2" xref: reactome:R-HSA-69005 "Cdc6 protein is phosphorylated by CDK" xref: reactome:R-HSA-69227 "Cyclin D:CDK4/6 phosphorylates RB1 and prevents RB1 binding to E2F1/2/3:DP1/2 complexes" xref: reactome:R-HSA-69754 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A1:Cdc2 complexes" xref: reactome:R-HSA-69756 "Phosphorylation of proteins involved in G2/M transition by active Cyclin A2:Cdc2 complexes" xref: reactome:R-HSA-9008412 "CDK4 phosphorylates RUNX2" xref: reactome:R-HSA-9009282 "CDK1 phosphorylates RUNX2" is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0097472 ! cyclin-dependent protein kinase activity [Term] id: GO:0004694 name: eukaryotic translation initiation factor 2alpha kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [eukaryotic translation initiation factor 2 alpha subunit] = ADP + [eukaryotic translation initiation factor 2 alpha subunit] phosphate." [GOC:mah, InterPro:IPR015516] xref: EC:2.7.11 is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0004697 name: protein kinase C activity namespace: molecular_function alt_id: GO:0004701 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol." [EC:2.7.11.13] synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] synonym: "cPKC" RELATED [EC:2.7.11.13] synonym: "cPKCalpha" RELATED [EC:2.7.11.13] synonym: "cPKCbeta" RELATED [EC:2.7.11.13] synonym: "cPKCgamma" RELATED [EC:2.7.11.13] synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] synonym: "nPKC" RELATED [EC:2.7.11.13] synonym: "nPKCdelta" RELATED [EC:2.7.11.13] synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] synonym: "nPKCeta" RELATED [EC:2.7.11.13] synonym: "nPKCtheta" RELATED [EC:2.7.11.13] synonym: "PKC" RELATED [EC:2.7.11.13] synonym: "PKC activity" EXACT [] synonym: "Pkc1p" RELATED [EC:2.7.11.13] synonym: "PKCalpha" RELATED [EC:2.7.11.13] synonym: "PKCbeta" RELATED [EC:2.7.11.13] synonym: "PKCdelta" RELATED [EC:2.7.11.13] synonym: "PKCepsilon" RELATED [EC:2.7.11.13] synonym: "PKCgamma" RELATED [EC:2.7.11.13] synonym: "PKCzeta" RELATED [EC:2.7.11.13] synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] synonym: "STK24" RELATED [EC:2.7.11.13] xref: EC:2.7.11.13 xref: MetaCyc:2.7.11.13-RXN xref: reactome:R-HSA-198314 "DAG stimulates protein kinase C-delta" xref: reactome:R-HSA-2179413 "Activated PKC-alpha activate MMP3" xref: reactome:R-HSA-5138432 "DVL2 is phosphorylated by PKC" xref: reactome:R-HSA-5218805 "PKC autophosphorylates" xref: reactome:R-HSA-751040 "PKC phosphorylates G alpha (z)" xref: reactome:R-HSA-9626817 "PKC phosphorylates NCF1" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004698 name: calcium-dependent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-dependent PKC activity" EXACT [] synonym: "conventional protein kinase C activity" EXACT [PMID:9601053] xref: EC:2.7.11 xref: reactome:R-HSA-114683 "Phosphorylation of Platelet Sec-1" xref: reactome:R-HSA-114684 "Phosphorylation of Syntaxin-4" xref: reactome:R-HSA-416639 "Trafficking of GluR2-containing AMPA receptors to extrasynaptic sites" xref: reactome:R-HSA-421007 "Endocytosis of Ca impermeable AMPA receptors" is_a: GO:0004697 ! protein kinase C activity is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity [Term] id: GO:0004699 name: calcium-independent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-independent PKC activity" EXACT [] synonym: "novel protein kinase C activity" EXACT [PMID:9601053] xref: reactome:R-HSA-5607740 "PKC-delta phosphorylates CARD9" is_a: GO:0004697 ! protein kinase C activity [Term] id: GO:0004702 name: obsolete signal transducer, downstream of receptor, with serine/threonine kinase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [EC:2.7.11.13, GOC:bf, GOC:mah] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein serine/threonine kinase activity" EXACT [] synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] xref: EC:2.7.11 is_obsolete: true [Term] id: GO:0004703 name: G protein-coupled receptor kinase activity namespace: molecular_function alt_id: GO:0004678 def: "Catalysis of the reaction: ATP + G protein-coupled receptor = ADP + G protein-coupled receptor phosphate." [GOC:dph] synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] synonym: "GPCR phosphorylating protein kinase activity" EXACT [] synonym: "GPCRK" RELATED [EC:2.7.11.16] synonym: "GRK4" RELATED [EC:2.7.11.16] synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004704 name: NF-kappaB-inducing kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of the alpha or beta subunit of the inhibitor of kappaB kinase complex (IKK)." [PMID:20685151] synonym: "NIK" EXACT [] xref: EC:2.7.11 is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0004705 name: JUN kinase activity namespace: molecular_function def: "Catalysis of the reaction: JUN + ATP = JUN phosphate + ADP. This reaction is the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732] synonym: "c-Jun N-terminal kinase activity" NARROW [] synonym: "JNK" EXACT [] synonym: "JNK3alpha1" RELATED [] synonym: "SAPK1" NARROW [] xref: EC:2.7.11 xref: reactome:R-HSA-168136 "Activated JNKs phosphorylate c-JUN" xref: reactome:R-HSA-204949 "NRIF and TRAF6 may activate JNK" xref: reactome:R-HSA-205075 "JNK phosphorylates BIM, BAD and other targets" xref: reactome:R-HSA-205132 "NRAGE activates JNK" is_a: GO:0016909 ! SAP kinase activity [Term] id: GO:0004706 name: JUN kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the reaction: JNKK + ATP = JNKK phosphate + ADP. This reaction is the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] synonym: "JNK kinase kinase activity" RELATED [] synonym: "JNKKK" EXACT [] xref: EC:2.7.11 is_a: GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0004707 name: MAP kinase activity namespace: molecular_function alt_id: GO:0008338 alt_id: GO:0008339 alt_id: GO:0016908 def: "Catalysis of the reaction: protein + ATP = protein phosphate + ADP. This reaction is the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] synonym: "Dp38" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "ERK1" EXACT [] synonym: "ERK2" RELATED [] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "LeMPK3" RELATED [EC:2.7.11.24] synonym: "MAP kinase 1 activity" NARROW [] synonym: "MAP kinase 2 activity" NARROW [] synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] synonym: "MAPK" RELATED [EC:2.7.11.24, PMID:20811974] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "MP kinase activity" NARROW [] synonym: "Mpk2" NARROW [] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p38" NARROW [] synonym: "p38-2" RELATED [EC:2.7.11.24] synonym: "p38delta" RELATED [EC:2.7.11.24] synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p42mapk" RELATED [EC:2.7.11.24] synonym: "p44mpk" RELATED [EC:2.7.11.24] synonym: "PMK-1" RELATED [EC:2.7.11.24] synonym: "PMK-2" RELATED [EC:2.7.11.24] synonym: "PMK-3" RELATED [EC:2.7.11.24] synonym: "pp42" RELATED [EC:2.7.11.24] synonym: "pp44mapk" RELATED [EC:2.7.11.24] synonym: "SAPK2" NARROW [] synonym: "STK26" RELATED [EC:2.7.11.24] xref: EC:2.7.11.24 xref: KEGG:R00162 xref: MetaCyc:2.7.11.24-RXN xref: reactome:R-HSA-198733 "ERK5 is activated" xref: reactome:R-HSA-451366 "Activation of p38MAPK by DSCAM" xref: reactome:R-HSA-5654560 "Activated ERK1/2 threonine-phosphorylates FGFR1-associated FRS2." xref: reactome:R-HSA-5654562 "Activated ERK1/2 threonine-phosphorylates FGFR2-associated FRS2" xref: reactome:R-HSA-5654565 "Activated ERK1/2 threonine-phosphorylates FGFR3-associated FRS2." xref: reactome:R-HSA-5654566 "Activated ERK1/2 threonine-phosphorylates FGFR4-associated FRS2." xref: reactome:R-HSA-73722 "Phosphorylation of UBF-1:rDNA Promoter" xref: reactome:R-HSA-9626832 "MAPK1 or MAPK3 phosphorylates NCF1 at Ser345" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004708 name: MAP kinase kinase activity namespace: molecular_function def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in a MAP kinase (MAPK) substrate." [ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] synonym: "ERK activator kinase activity" EXACT [] synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] synonym: "MAP2K" RELATED [EC:2.7.12.2] synonym: "MAPK activator activity" EXACT [GOC:vw] synonym: "MAPKK" RELATED [EC:2.7.12.2, PMID:20811974] synonym: "MAPKK activity" EXACT [] synonym: "MAPKK1" RELATED [EC:2.7.12.2] synonym: "MEK activity" BROAD [] synonym: "MEK1" RELATED [EC:2.7.12.2] synonym: "MEK2" RELATED [EC:2.7.12.2] synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] synonym: "MKK" RELATED [EC:2.7.12.2] synonym: "MKK2" RELATED [EC:2.7.12.2] synonym: "MKK4" RELATED [EC:2.7.12.2] synonym: "MKK6" RELATED [EC:2.7.12.2] synonym: "MKK7" RELATED [EC:2.7.12.2] synonym: "STK27" RELATED [EC:2.7.12.2] xref: EC:2.7.11 xref: MetaCyc:2.7.12.2-RXN xref: reactome:R-HSA-1247960 "Activation of p38 MAPK" xref: reactome:R-HSA-448951 "Activation of p38 alpha/beta MAPK" is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity [Term] id: GO:0004709 name: MAP kinase kinase kinase activity namespace: molecular_function alt_id: GO:0004710 def: "Catalysis of the phosphorylation and activation of a MAP kinase kinase; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] synonym: "cMos" RELATED [EC:2.7.11.25] synonym: "cRaf" RELATED [EC:2.7.11.25] synonym: "MAP3K" RELATED [EC:2.7.11.25, PMID:20811974] synonym: "MAPK/ERK kinase kinase activity" EXACT [] synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] synonym: "MEKK" RELATED [EC:2.7.11.25] synonym: "MEKK activity" EXACT [] synonym: "MEKK1" RELATED [EC:2.7.11.25] synonym: "MEKK2" RELATED [EC:2.7.11.25] synonym: "MEKK3" RELATED [EC:2.7.11.25] synonym: "Mil/Raf" RELATED [EC:2.7.11.25] synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] synonym: "MLTK" RELATED [EC:2.7.11.25] synonym: "MLTKa" RELATED [EC:2.7.11.25] synonym: "MLTKb" RELATED [EC:2.7.11.25] synonym: "REKS" RELATED [EC:2.7.11.25] synonym: "STK28" RELATED [EC:2.7.11.25] xref: EC:2.7.11.25 xref: MetaCyc:2.7.11.25-RXN xref: reactome:R-HSA-392530 "p-S400-Cot phosphorylates NIK" xref: reactome:R-HSA-451649 "TPL2 phosphorylates MEK1, SEK1" xref: reactome:R-HSA-727819 "TAK1 phosphorylates MKK6" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004711 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the reaction: ribosomal protein S6 + ATP = ribosomal protein S6 phosphate + ATP." [GOC:mah, PMID:9822608] xref: EC:2.7.11 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004712 name: protein serine/threonine/tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; ATP + a protein threonine = ADP + protein threonine phosphate; and ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [GOC:mah] synonym: "ADK1" RELATED [EC:2.7.12.1] synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] synonym: "CLK1" RELATED [EC:2.7.12.1] synonym: "dDYRK2" RELATED [EC:2.7.12.1] synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] synonym: "dual-specificity protein kinase" BROAD [] synonym: "Mps1p" RELATED [EC:2.7.12.1] synonym: "protein threonine/tyrosine kinase activity" NARROW [] xref: EC:2.7.12.1 xref: reactome:R-HSA-3238999 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5" xref: reactome:R-HSA-450333 "Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3" xref: reactome:R-HSA-5672969 "Phosphorylation of RAF" xref: reactome:R-HSA-5674373 "MAP2Ks phosphorylate MAPK at the Golgi membrane" xref: reactome:R-HSA-6802910 "Activated MAP2Ks phosphorylate MAPKs downstream of high kinase activity BRAF mutants" xref: reactome:R-HSA-6802916 "RAF is phosphorylated downstream of moderate kinase activity BRAF mutants" xref: reactome:R-HSA-6802918 "Activated MAP2Ks phosphorylate MAPKs downstream of inactive BRAF mutants" xref: reactome:R-HSA-6802921 "Activated MAP2Ks phosphorylate MAPKs downstream of moderate kinase activity BRAF mutants" xref: reactome:R-HSA-6802922 "Activated MAP2Ks phosphorylate MAPKs downstream of oncogenic RAS" xref: reactome:R-HSA-6802924 "RAF is phosphorylated downstream of oncogenic RAS" xref: reactome:R-HSA-6802927 "BRAF and RAF fusion mutant dimers are phosphorylated" xref: reactome:R-HSA-6802941 "RAF is paradoxically phosphorylated downstream of kinase-inactive RAF" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004713 name: protein tyrosine kinase activity namespace: molecular_function alt_id: GO:0004718 def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] synonym: "JAK" NARROW [] synonym: "Janus kinase activity" NARROW [] synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10 xref: reactome:R-HSA-112333 "SRC autophosphorylation is positively regulated by InlA-bound CDH1" xref: reactome:R-HSA-114600 "Fyn/Lyn-mediated phosphorylation of FcR1 gamma" xref: reactome:R-HSA-1168394 "STAT5 tyrosine phosphorylation" xref: reactome:R-HSA-1169421 "Trans-autophosphorylation of activated ligand-responsive EGFR mutant dimers" xref: reactome:R-HSA-1225952 "Phosphorylation of SHC1 by ligand-responsive p-6Y-EGFR mutants" xref: reactome:R-HSA-1225960 "Phosphorylation of CBL by ligand-responsive p-6Y-EGFR mutants" xref: reactome:R-HSA-1247844 "Phosphorylation of PLCG1 by ligand-responsive p-6Y-EGFR mutants" xref: reactome:R-HSA-1248655 "Trans-autophosphorylation of EGFRvIII mutant dimers" xref: reactome:R-HSA-1250195 "SHC1 phosphorylation by ERBB2 heterodimers" xref: reactome:R-HSA-1250315 "Trans-autophosphorylation of ERBB4 homodimers" xref: reactome:R-HSA-1250348 "Phosphorylation of SHC1 by ERBB4 homodimers" xref: reactome:R-HSA-1251922 "PLCG1 phosphorylation by p-EGFR:p-ERBB2" xref: reactome:R-HSA-1295540 "IL7:p-Y449-IL7R:JAK1:IL2RG:p-JAK3:STAT5A,STAT5B phosphorylates STAT5" xref: reactome:R-HSA-1295609 "SRC phosphorylates SPRY2 on Y55 and Y227" xref: reactome:R-HSA-1307963 "Autocatalytic phosphorylation of BetaKlotho-bound FGFR4" xref: reactome:R-HSA-1433418 "Phosphorylation of JAK2" xref: reactome:R-HSA-1433454 "Phosphorylation of GAB2 by SFKs" xref: reactome:R-HSA-1433488 "Phosphorylation of SHP2 by SFKs" xref: reactome:R-HSA-1433506 "Phosphorylation of APS" xref: reactome:R-HSA-1433542 "Phosphorylation and activation of VAV1" xref: reactome:R-HSA-1470009 "Phosphorylation of STATs" xref: reactome:R-HSA-1524186 "Phosphorylation of PLCgamma by PDGFR" xref: reactome:R-HSA-1671691 "PRLR-bound STAT5 is phosphorylated" xref: reactome:R-HSA-170991 "SRC-1 autophosphorylates" xref: reactome:R-HSA-171011 "Binding and activation of MAP Kinase" xref: reactome:R-HSA-177930 "GAB1 phosphorylation by EGFR kinase" xref: reactome:R-HSA-177934 "EGFR autophosphorylation" xref: reactome:R-HSA-177937 "Phosphorylation of EGFR by SRC kinase" xref: reactome:R-HSA-182969 "Phosphorylation of CBL (EGFR:CBL)" xref: reactome:R-HSA-183058 "Phosphorylation of CBL (EGFR:GRB2:CBL)" xref: reactome:R-HSA-1839065 "Phosphorylation of cytosolic FGFR1 fusion dimers" xref: reactome:R-HSA-1839067 "Phosphorylation of BCR moiety of BCR-FGFR1" xref: reactome:R-HSA-1839098 "Activated FGFR1 mutants and fusions phosphorylate PLCG1" xref: reactome:R-HSA-1839112 "Phosphorylation of STAT5 by cytosolic FGFR1 fusions" xref: reactome:R-HSA-186786 "Autophosphorylation of PDGF beta receptors" xref: reactome:R-HSA-1888198 "FGFR1OP-FGFR1 phosphorylates STAT1 and STAT3" xref: reactome:R-HSA-190326 "Autocatalytic phosphorylation of FGFR4" xref: reactome:R-HSA-190385 "Autocatalytic phosphorylation of FGFR3b" xref: reactome:R-HSA-190388 "Autocatalytic phosphorylation of FGFR3c" xref: reactome:R-HSA-190408 "Autocatalytic phosphorylation of FGFR2b" xref: reactome:R-HSA-190413 "Autocatalytic phosphorylation of FGFR2c" xref: reactome:R-HSA-190427 "Autocatalytic phosphorylation of FGFR1b" xref: reactome:R-HSA-190429 "Autocatalytic phosphorylation of FGFR1c" xref: reactome:R-HSA-191062 "Autocatalytic phosphorylation of Klotho-bound FGFR1c" xref: reactome:R-HSA-1963581 "Trans-autophosphorylation of p-Y877-ERBB2 heterodimers" xref: reactome:R-HSA-1963582 "Trans-autophosphorylation of ERBB2 heterodimers" xref: reactome:R-HSA-1963586 "SRC family kinases phosphorylate ERBB2" xref: reactome:R-HSA-1982066 "Ligand-independent phosphorylation of overexpressed FGFR1" xref: reactome:R-HSA-2012073 "Autocatalytic phosphorylation of FGFR3c P250R mutant" xref: reactome:R-HSA-2012082 "Autocatalytic phosphorylation of FGFR3 cysteine mutants" xref: reactome:R-HSA-2012087 "Autocatalytic phosphorylation of FGFR4 Y367C mutant" xref: reactome:R-HSA-202165 "Phosphorylation of ITAM motifs in CD3 complexes" xref: reactome:R-HSA-202168 "Phosphorylation of ZAP-70 by Lck" xref: reactome:R-HSA-202174 "Activation of ZAP-70" xref: reactome:R-HSA-202216 "Phosphorylation of SLP-76" xref: reactome:R-HSA-202233 "Inactivation of Lck by Csk" xref: reactome:R-HSA-202245 "Phosphorylation of TBSMs in LAT" xref: reactome:R-HSA-202248 "Phosphorylation of PLC-gamma1" xref: reactome:R-HSA-202291 "Activation of Lck" xref: reactome:R-HSA-202307 "Change of PKC theta conformation" xref: reactome:R-HSA-2023455 "Autocatalytic phosphorylation of FGFR1c P252X mutant dimers" xref: reactome:R-HSA-2023460 "Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity" xref: reactome:R-HSA-2029268 "Phosphorylation and activation of PLCG" xref: reactome:R-HSA-2029449 "Phosphorylation of SYK by Src kinases" xref: reactome:R-HSA-2029453 "Phosphorylation of VAV" xref: reactome:R-HSA-2029459 "Sequestering and phosphorylation Fc gamma receptors in the lipid rafts" xref: reactome:R-HSA-2029984 "Autocatalytic phosphorylation of FGFR2 ligand-independent mutants" xref: reactome:R-HSA-2029989 "Autocatalytic phosphorylation of overexpressed FGFR2 variants" xref: reactome:R-HSA-2033485 "Autocatalytic phosphorylation of FGFR3 point mutants with enhanced kinase activity" xref: reactome:R-HSA-2033486 "Autocatalytic phosphorylation of FGFR2c mutants with enhanced ligand binding" xref: reactome:R-HSA-2033488 "Autocatalytic phosphorylation of FGFR2b mutants with enhanced ligand binding" xref: reactome:R-HSA-2033490 "Autocatalytic phosphorylation of FGFR2 point mutants with enhanced kinase activity" xref: reactome:R-HSA-2038387 "Autocatalytic phosphorylation of FGFR3 t(4;14) translocation mutants" xref: reactome:R-HSA-2038944 "Autocatalytic phosphorylation of FGFR4 mutants with enhanced kinase activity" xref: reactome:R-HSA-205289 "Autophosphorylation of KIT" xref: reactome:R-HSA-210291 "Phosphorylation of PECAM-1 by Fyn or Lyn or c-Src" xref: reactome:R-HSA-210872 "Trans-phosphorylation of Tie2" xref: reactome:R-HSA-212710 "EGFR activates PLC-gamma1 by phosphorylation" xref: reactome:R-HSA-2130194 "ABL phosphorylates WAVEs" xref: reactome:R-HSA-2197698 "Phosphorylation of WASP/N-WASP" xref: reactome:R-HSA-2201322 "TIRAP is phosphorylated by BTK" xref: reactome:R-HSA-2395412 "Phosphorylation of SYK" xref: reactome:R-HSA-2395439 "Phosphorylation of DAP12" xref: reactome:R-HSA-2395801 "Phosphorylation of LAT by p-SYK" xref: reactome:R-HSA-2396594 "Phosphorylation of SLP-76 by p-SYK" xref: reactome:R-HSA-2404193 "IGF1R phosphorylates SHC1" xref: reactome:R-HSA-2404199 "IGF1,2:IGF1R autophosphorylates" xref: reactome:R-HSA-2424484 "Phosphorylation of BTK by p-SYK" xref: reactome:R-HSA-2424486 "Phosphorylation and activation of VAV2/VAV3 by SYK" xref: reactome:R-HSA-2424487 "Phosphorylation of PLC-gamma by p-BTK/p-SYK" xref: reactome:R-HSA-2428926 "IGF1,2:p-Y1161,1165,1166-IGF1R phosphorylates IRS1,2,4" xref: reactome:R-HSA-2454208 "Phosphorylation of beta and gamma subunits by LYN" xref: reactome:R-HSA-2454239 "Phosphorylation of SYK" xref: reactome:R-HSA-2586553 "JAK2 Phosphorylates LEPR" xref: reactome:R-HSA-2586555 "JAK2 Autophosphorylates in Response to Leptin" xref: reactome:R-HSA-2671742 "JAK2 Phosphorylates SHP2 (PTPN11) in Response to Leptin" xref: reactome:R-HSA-2671829 "JAK2 Phosphorylates STAT5 in Response to Leptin" xref: reactome:R-HSA-2671850 "JAK2 Phosphoryates STAT3 in Response to Leptin" xref: reactome:R-HSA-2730833 "Phosphorylation of TEC kinases by p-SYK" xref: reactome:R-HSA-2730843 "Phosphorylation of LAT by p-SYK" xref: reactome:R-HSA-2730851 "Phosphorylation of SLP-76 by p-SYK" xref: reactome:R-HSA-2730858 "Autophosphorylation of BTK/ITK" xref: reactome:R-HSA-2730860 "Phosphorylation of GAB2 by SYK/FYN" xref: reactome:R-HSA-2730862 "Autophosphorylation of LYN kinase" xref: reactome:R-HSA-2730882 "Phosphorylation of PKC-theta" xref: reactome:R-HSA-2730884 "Phosphorylation of NTAL by p-SYK/Lyn" xref: reactome:R-HSA-2730886 "Phosphorylation of SHC by SYK kinase" xref: reactome:R-HSA-2730888 "Phosphorylation of PLC-gamma" xref: reactome:R-HSA-3215391 "PRMT5 is tyrosine phosphorylated by JAK2 V617F" xref: reactome:R-HSA-373747 "Phosphorylation of nephrin by FYN" xref: reactome:R-HSA-373750 "SEMA4D interacts with Plexin-B1:ErbB2" xref: reactome:R-HSA-374701 "Phosphorylation of DCC by Fyn" xref: reactome:R-HSA-377640 "Autophosphorylation of SRC" xref: reactome:R-HSA-380780 "Activation of Src" xref: reactome:R-HSA-388831 "Phosphorylation of CD28" xref: reactome:R-HSA-388833 "Phosphorylation of CTLA-4" xref: reactome:R-HSA-389083 "Autophosphorylation of PDGF alpha receptors" xref: reactome:R-HSA-389086 "Autophosphorylation of PDGF alpha/beta receptors" xref: reactome:R-HSA-389354 "Activation of Vav1" xref: reactome:R-HSA-391156 "Phosphorylation of ITIM motif in SIRP alpha" xref: reactome:R-HSA-391865 "Recruitment of FAK to NCAM1:Fyn in lipid rafts" xref: reactome:R-HSA-391866 "Phosphorylation of FAK by Src kinase" xref: reactome:R-HSA-391871 "Autophosphorylation of NCAM1 bound Fyn" xref: reactome:R-HSA-3928578 "EPH receptors autophosphorylate" xref: reactome:R-HSA-3928580 "SFKs phosphorylate EFNBs" xref: reactome:R-HSA-3928583 "FYN phosphorylates NMDAR2B" xref: reactome:R-HSA-3928594 "SFKs phosphorylate GIT1" xref: reactome:R-HSA-3928604 "SFKs phosphorylate VAV2,3" xref: reactome:R-HSA-3928610 "PTK2 autophosphorylates at Y397" xref: reactome:R-HSA-3928627 "EPHB phosphorylates TIAM1" xref: reactome:R-HSA-3928648 "SFKs phosphorylate NGEF" xref: reactome:R-HSA-399934 "Phosphorylation of Plexin-A" xref: reactome:R-HSA-399946 "Recruitment and activation of Cdk5" xref: reactome:R-HSA-399947 "Tyrosine phosphorylation of CRMPs by Fes" xref: reactome:R-HSA-4093332 "p-EPHB phosphorylates SDC2" xref: reactome:R-HSA-418859 "Phosphorylation of Unc5C" xref: reactome:R-HSA-418872 "Phosphorylation of FADK1" xref: reactome:R-HSA-419646 "SEMA4D interacts with Plexin-B1:Met" xref: reactome:R-HSA-428888 "Phosphorylation of ROBO1 by ABL kinase" xref: reactome:R-HSA-429441 "SYK activation by SRC" xref: reactome:R-HSA-429449 "Syk activation leads to SLP-76 activation" xref: reactome:R-HSA-432129 "FGR binds and phosphorylates LRP8" xref: reactome:R-HSA-434836 "Syk/Lck phosphorylate LAT" xref: reactome:R-HSA-4420117 "VEGFR2 autophosphorylates" xref: reactome:R-HSA-4420121 "SFKs phosphorylate PLCG1" xref: reactome:R-HSA-4420128 "SRC-1 phosphorylates SHB" xref: reactome:R-HSA-4420206 "Phosphorylation of SRC-1" xref: reactome:R-HSA-443817 "Phosphorylation of L1 by EPHB2" xref: reactome:R-HSA-445076 "Phosphorylation of Y1229 in L1" xref: reactome:R-HSA-445084 "Phosphorylation of L1 by SRC" xref: reactome:R-HSA-445085 "Phosphorylation of VAV2" xref: reactome:R-HSA-445091 "Phosphorylation of Neurofascin" xref: reactome:R-HSA-451942 "Within the IL-2R complex JAK3 phosphorylates JAK1" xref: reactome:R-HSA-452097 "Recruited STAT5 is phosphorylated" xref: reactome:R-HSA-452100 "SHC1 bound to IL2 receptor is phosphorylated" xref: reactome:R-HSA-452122 "JAK1 phosphorylates Y338, Y392 and Y510 of IL2RB" xref: reactome:R-HSA-508282 "SYK is a substrate for JAK1" xref: reactome:R-HSA-5218640 "SRC-1 phosphorylates p-Y397-PTK2" xref: reactome:R-HSA-5218642 "PTK2 autophosphorylates" xref: reactome:R-HSA-5218806 "FYN autophosphorylates" xref: reactome:R-HSA-5218809 "PTK2 and SRC-1 phosphorylate PXN on Y31 and Y118" xref: reactome:R-HSA-5218812 "FYN phosphorylates PAK2" xref: reactome:R-HSA-5218820 "Src kinases phosphorylate VAV" xref: reactome:R-HSA-5218828 "PTK2/SRC-1 phosphorylates BCAR1" xref: reactome:R-HSA-5218830 "SRC-1 phosphorylates PTK2-beta" xref: reactome:R-HSA-5218851 "p-Y402-PTK2B phosphorylates p-5Y,S732-PTK2 on Y407" xref: reactome:R-HSA-5357429 "AXL autophosphorylates on Y772 and Y814" xref: reactome:R-HSA-5607745 "1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG" xref: reactome:R-HSA-5607750 "SRC kinase phosphorylates CLEC7A:1,3-beta-D-glucan" xref: reactome:R-HSA-5621355 "LYN and FYN phosphorylate FCER1G in CLEC6A:FCERG and CLEC4E:FCERG" xref: reactome:R-HSA-5621363 "SYK phosphorylates PLCG2 in p-6Y-SYK:p-Y65,Y76-FCER1G:PLCG2" xref: reactome:R-HSA-5621370 "SYK autophosphorylates" xref: reactome:R-HSA-5624486 "SFKs phosphorylates RAF1 on Y340,Y341" xref: reactome:R-HSA-5637795 "Phosphorylation of PLC-gamma 1 by p-EGFRvIII mutant" xref: reactome:R-HSA-5637796 "Phosphorylation of SHC1 by p-5Y-EGFRvIII" xref: reactome:R-HSA-5654147 "Activated FGFR2 phosphorylates PLCG1" xref: reactome:R-HSA-5654149 "Activated FGFR1 phosphorylates PLCG1" xref: reactome:R-HSA-5654151 "Activated FGFR4 phosphorylates PLCG1" xref: reactome:R-HSA-5654222 "Activated FGFR3 phosphorylates PLCG1" xref: reactome:R-HSA-5654397 "Activated FGFR2 phosphorylates FRS2" xref: reactome:R-HSA-5654407 "Activated FGFR2 phosphorylates SHC1" xref: reactome:R-HSA-5654408 "Activated FGFR3 phosphorylates FRS2" xref: reactome:R-HSA-5654418 "Activated FGFR4 phosphorylates FRS2" xref: reactome:R-HSA-5654428 "Activated FGFR4 phosphorylates SHC1" xref: reactome:R-HSA-5654545 "Ligand-independent phosphorylation of overexpressed FGFR1c" xref: reactome:R-HSA-5654575 "Activated FGFR1 phosphorylates FRS2" xref: reactome:R-HSA-5654578 "Activated FGFR1 phosphorylates FRS3" xref: reactome:R-HSA-5654582 "Activated FGFR1 phosphorylates SHC1" xref: reactome:R-HSA-5654587 "Activated FGFR1:p-FRS phosphorylates PPTN11" xref: reactome:R-HSA-5654605 "Activated FGFR2 phosphorylates FRS3" xref: reactome:R-HSA-5654607 "Activated FGFR2 phosphorylates PPTN11" xref: reactome:R-HSA-5654628 "Activated FGFR3 phosphorylates FRS3" xref: reactome:R-HSA-5654631 "Activated FGFR3 phosphorylates PPTN11" xref: reactome:R-HSA-5654634 "Activated FGFR3 phosphorylates SHC1" xref: reactome:R-HSA-5654653 "Activated FGFR4 phosphorylates FRS3" xref: reactome:R-HSA-5654655 "Activated FGFR4 phosphorylates PPTN11" xref: reactome:R-HSA-5655243 "Activated FGFR3 mutants phosphorylate PLCG1" xref: reactome:R-HSA-5655268 "Activated FGFR2 mutants phosphorylate FRS2" xref: reactome:R-HSA-5655270 "Activated FGFR3 mutants phosphorylate FRS2" xref: reactome:R-HSA-5655278 "Activated FGFR1 mutants phosphorylate FRS2" xref: reactome:R-HSA-5655284 "Activated FGFR4 mutants phosphorylate FRS2" xref: reactome:R-HSA-5655301 "Activated FGFR2 mutants phosphorylate PLCG1" xref: reactome:R-HSA-5655341 "Activated FGFR4 mutants phosphorylate PLCG1" xref: reactome:R-HSA-5683930 "WICH phosphorylates H2AFX on Y142" xref: reactome:R-HSA-5686587 "ABL1 phosphorylates RAD52" xref: reactome:R-HSA-5690702 "LYN phosphorylates CD22" xref: reactome:R-HSA-6784006 "STAT3 is phosphorylated by p-Y-JAK1,P-Y-TYK2" xref: reactome:R-HSA-6784319 "JAK1,TYK2 phosphorylate JAK1,TYK2" xref: reactome:R-HSA-6790087 "HVEM induses BTLA phosphorylation" xref: reactome:R-HSA-6806974 "MET dimers autophosphorylate" xref: reactome:R-HSA-873918 "Transphosphorylation of JAK1" xref: reactome:R-HSA-873919 "Phosphorylation of JAK2" xref: reactome:R-HSA-873922 "Phosphorylation of STAT1 by JAK kinases" xref: reactome:R-HSA-873924 "Phosphorylation of IFNGR1 by JAK kinases" xref: reactome:R-HSA-879907 "Tyrosine kinases phosphorylate the receptor" xref: reactome:R-HSA-879909 "Activation of STAT5a/b by JAK2" xref: reactome:R-HSA-879925 "SHC1 bound to the common beta chain becomes tyrosine phosphorylated" xref: reactome:R-HSA-8847977 "FRK phosphorylates PTEN" xref: reactome:R-HSA-8848005 "ERBB2 promotes PTK6 autophosphorylation" xref: reactome:R-HSA-8848077 "PTK6 phosphorylates STAP2" xref: reactome:R-HSA-8848124 "PTK6 phosphorylates STAT3" xref: reactome:R-HSA-8848436 "PTK6 phosphorylates CDKN1B" xref: reactome:R-HSA-8848606 "PTK6 phosphorylates PXN" xref: reactome:R-HSA-8848726 "PTK6 phosphorylates BCAR1" xref: reactome:R-HSA-8848758 "PTK6 phosphorylates AKT1" xref: reactome:R-HSA-8848776 "PTK6 phosphorylates DOK1" xref: reactome:R-HSA-8848818 "PTK6 phosphorylates CBL" xref: reactome:R-HSA-8848873 "PTK6 phosphorylates ARAP1" xref: reactome:R-HSA-8848975 "PTK6 phosphorylates KHDRBS1" xref: reactome:R-HSA-8849032 "PTK6 phosphorylates KHDRBS2" xref: reactome:R-HSA-8849042 "PTK6 phosphorylates KHDRBS3" xref: reactome:R-HSA-8849068 "PTK6 phosphorylates ARHGAP35" xref: reactome:R-HSA-8849102 "SRMS phosphorylates PTK6" xref: reactome:R-HSA-8849463 "PTK6 phosphorylates SFPQ" xref: reactome:R-HSA-8851890 "MET phosphorylates SHC1-2" xref: reactome:R-HSA-8851933 "MET phosphorylates GAB1" xref: reactome:R-HSA-8853309 "Autocatalytic phosphorylation of FGFR3 fusions" xref: reactome:R-HSA-8853313 "FGFR2 fusions autophosphorylate" xref: reactome:R-HSA-8853315 "Activated FGFR3 fusions phosphorylate FRS2" xref: reactome:R-HSA-8853325 "Plasma membrane FGFR1 fusions autophosphorylate" xref: reactome:R-HSA-8855237 "FYN phosphorylates DAB1 in RELN:VLDLR:DAB1:SH3KBP1" xref: reactome:R-HSA-8857555 "EGFR phosphorylates GPNMB" xref: reactome:R-HSA-8857577 "LINC01139 facilitates PTK6 autophosphorylation" xref: reactome:R-HSA-8857925 "Inhibition of PP2A activity by phosphorylation of the catalytic subunit at tyrosine Y307" xref: reactome:R-HSA-8867041 "EGFR phosphorylates EPS15" xref: reactome:R-HSA-8874078 "PTK2 autophosphorylates" xref: reactome:R-HSA-8874080 "SRC phosphorylates PTK2" xref: reactome:R-HSA-8874082 "MET phosphorylates PTK2" xref: reactome:R-HSA-8875451 "MET phosphorylates CBL" xref: reactome:R-HSA-8875817 "MET phosphorylates STAT3" xref: reactome:R-HSA-8876230 "InlB:MET dimer trans-autophophorylates" xref: reactome:R-HSA-8876246 "InlB-activated MET phosphorylates CBL" xref: reactome:R-HSA-8876948 "SRC phosphorylates InlA-bound CDH1 and CTNNB1" xref: reactome:R-HSA-8937728 "SRC phosphorylates RUNX1" xref: reactome:R-HSA-8937807 "SRC phosphorylates RUNX3" xref: reactome:R-HSA-8937844 "SRC,YES1 phosphorylate YAP1" xref: reactome:R-HSA-8942607 "Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes" xref: reactome:R-HSA-8956659 "ABL1 phosphorylates YAP1" xref: reactome:R-HSA-9006323 "Phospho-JAK2 phosphorylates EPOR" xref: reactome:R-HSA-9006332 "JAK2 transphosphorylates and is activated in response to Erythropoietin" xref: reactome:R-HSA-9011241 "SRC phosphorylates ROBO3.1 in response to NTN1" xref: reactome:R-HSA-9012650 "JAK2 and LYN phosphorylate STAT5 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2" xref: reactome:R-HSA-9018572 "EGFR phosphorylates NOTCH3" xref: reactome:R-HSA-9024726 "LYN phosphorylates CRKL in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:CRKL:RAPGEF1" xref: reactome:R-HSA-9026464 "BDNF-bound NTRK2 dimers trans-autophosphorylate" xref: reactome:R-HSA-9026502 "NTF3-bound NTRK2 dimers trans-autophosphorylate" xref: reactome:R-HSA-9026510 "NTF4-bound NTRK2 dimers trans-autophosphorylate" xref: reactome:R-HSA-9026579 "NTRK2 phosphorylates PLCG1" xref: reactome:R-HSA-9026890 "NTRK2 phosphorylates SHC1" xref: reactome:R-HSA-9027272 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2 phosphorylates IRS2" xref: reactome:R-HSA-9027273 "JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1" xref: reactome:R-HSA-9027425 "LYN phosphorylates PLCG1,2 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:PLCG1,2" xref: reactome:R-HSA-9028728 "NTRK2 phosphorylates FRS2" xref: reactome:R-HSA-9029151 "JAK2 phosphorylates VAV1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-CRKL:RASGEF1:p-Y-SHC1:GRB2:VAV1" xref: reactome:R-HSA-9029155 "JAK2 phosphorylates SHC1 in EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:p-CRKL:RABGEF1:SHC1" xref: reactome:R-HSA-9032426 "NTRK2 phosphorylates FRS3" xref: reactome:R-HSA-9032532 "NTRK2-bound FYN autophosphorylates" xref: reactome:R-HSA-9032601 "FYN-mediated phosphorylation of GRIN2B" xref: reactome:R-HSA-9032854 "NTRK2 phosphorylates CDK5" xref: reactome:R-HSA-9033284 "NTRK2 promotes TIAM1 phosphorylation" xref: reactome:R-HSA-9034714 "NTRK3 dimers trans-autophosphorylate" xref: reactome:R-HSA-9034814 "NTRK3 phosphorylates PLCG1" xref: reactome:R-HSA-9034875 "NTRK3 phosphorylates SHC1" xref: reactome:R-HSA-9037040 "SRC,FYN phosphorylate NTRK2" xref: reactome:R-HSA-909718 "Formation of p-STAT1 homodimer" xref: reactome:R-HSA-909726 "Phosphorylation of STAT1" xref: reactome:R-HSA-909729 "Activation of JAK kinases" xref: reactome:R-HSA-909730 "Phosphorylation of INFAR1 by TYK2" xref: reactome:R-HSA-909732 "Phosphorylation of STAT2" xref: reactome:R-HSA-912629 "CBL is tyrosine phosphorylated" xref: reactome:R-HSA-9603420 "Activated NTRK3 promotes SRC autophosphorylation" xref: reactome:R-HSA-9606159 "BTK autophosphorylates" xref: reactome:R-HSA-9606162 "Phosphorylated BTK phosphorylates PLCG2" xref: reactome:R-HSA-9606163 "p-SYK and LYN phosphorylate BTK" xref: reactome:R-HSA-9612085 "SRC phosphorylates GluN2 (GRIN2) subunits of NMDARs" xref: reactome:R-HSA-9612996 "NTRK1,2 in ADCYAP1(2-742):ADCYAP1R1:NTRK1,2 autophosphorylates" xref: reactome:R-HSA-9613023 "NTRK1,2 in Ade-Rib:ADORA2A:NTRK1,2 autophosphorylates" xref: reactome:R-HSA-982807 "JAK2 phosphorylation of GHR" xref: reactome:R-HSA-983703 "p-6Y-SYK phosphorylates BLNK (SLP65)" xref: reactome:R-HSA-983707 "SYK autophosphorylates at the activated BCR" xref: reactome:R-HSA-983709 "LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B)" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004714 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.1, GOC:mah] synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "sevenless receptor activity" RELATED [] xref: EC:2.7.10.1 xref: MetaCyc:2.7.10.1-RXN xref: reactome:R-HSA-166544 "TrkA receptor autophosphorylates" xref: reactome:R-HSA-167019 "SHC, complexed with TrkA, is tyrosine-phosphorylated" xref: reactome:R-HSA-167683 "TrkA phosphorylates PLCG1" xref: reactome:R-HSA-169905 "ARMS is phosphorylated by active TrkA receptor" xref: reactome:R-HSA-177933 "SHC1 phosphorylation by phosphorylated EGFR" xref: reactome:R-HSA-198295 "TRKA phosphorylates IRS" xref: reactome:R-HSA-6784324 "p-Y-JAK1,p-Y-TYK2 phosphorylate IL10RA" xref: reactome:R-HSA-74711 "Phosphorylation of IRS" xref: reactome:R-HSA-74715 "Autophosphorylation of insulin receptor" xref: reactome:R-HSA-74742 "Phosphorylation of SHC1" xref: reactome:R-HSA-8852552 "MST1R autophosphorylates" xref: reactome:R-HSA-8853792 "RET tyrosine phosphorylation" xref: reactome:R-HSA-8950269 "STAT3, STAT4 are phosphorylated by p-JAK2, p-TYK2 in IL23:IL23 receptor" xref: reactome:R-HSA-8950340 "IL27RA and IL6ST are phosphorylated after IL27:IL27 receptor interaction and JAK's phosphorylation" xref: reactome:R-HSA-8950354 "STAT4 is phosphorylated by p-JAK2 and/or p-Y-TYK2 after IL12:IL12R interaction" xref: reactome:R-HSA-8950364 "IL23R in IL23:IL23 receptor complex is phosphorylated" xref: reactome:R-HSA-8950405 "JAK1/JAK2 bound to IL35:IL6ST:IL12RB2 receptor are phosphorylated" xref: reactome:R-HSA-8950423 "JAK2, TYK2 in IL12A:IL12RB1:TYK2:IL12B:IL12RB2:JAK2 are phosphorylated" xref: reactome:R-HSA-8950453 "JAK1/JAK2 bound to IL12RB2:IL6ST receptor phosphorylates STAT1 and STAT4" xref: reactome:R-HSA-8950485 "STAT3 and STAT1 are phosphorylated by JAKs after IL27:IL27R interaction" xref: reactome:R-HSA-8950537 "JAK1, JAK2, TYK2 in IL27:EBI3:IL27RA:JAK1:IL6ST:(JAK1,JAK2,TYK2) are phosphorylated" xref: reactome:R-HSA-8950591 "JAK2, TYK2 in IL23A:IL12B:IL23R:JAK2:IL12RB1:TYK2 are phosphorylated" xref: reactome:R-HSA-8950757 "IL12RB2 in IL12A:IL12RB1:p-Y-TYK2:IL12B:IL12RB2:p-JAK2 is phosphorylated" xref: reactome:R-HSA-8982163 "IL19:IL20RA:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: reactome:R-HSA-8983300 "IL15RA:IL15:IL2RB:JAK1:IL2RG:JAK3 phosphorylates JAK3 and JAK1" xref: reactome:R-HSA-8983309 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates SHC1" xref: reactome:R-HSA-8983371 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3 phosphorylates STAT3 and STAT5" xref: reactome:R-HSA-8983424 "IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:GAB2 phosphorylates GAB2" xref: reactome:R-HSA-8986985 "IFNL1:p-Y343,Y517-IFNLR1:p-JAK1:IL10RB:p-TYK2:STAT1 phosphorylates STAT1, STAT2, STAT3, STAT4 and STAT5" xref: reactome:R-HSA-8986994 "IL26:IL20RA:JAK1:IL10RB:TYK2 phosphorylates JAK1, TYK2" xref: reactome:R-HSA-8986995 "IL22:IL22RA1:p-JAK1:IL10RB:p-TYK2 phosphorylates IL22RA" xref: reactome:R-HSA-8987012 "IL24:IL22RA1:JAK1:IL20RB phosphorylates JAK1" xref: reactome:R-HSA-8987040 "IFNL1:IFNLR1:p-JAK1:IL10RB:p-TYK2 phosphorylates IFNLR1" xref: reactome:R-HSA-8987042 "IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: reactome:R-HSA-8987070 "IL22:p-Y251,p-Y301-IL22RA1:p-JAK1:IL10RB:p-TYK2:STAT3 phosphorylates STAT3" xref: reactome:R-HSA-8987084 "IL19:IL20RA:JAK1:IL20RB phosphorylates JAK1" xref: reactome:R-HSA-8987096 "IL24:IL22RA1:p-JAK1:IL20RB:STAT3 phosphorylates STAT3" xref: reactome:R-HSA-8987129 "JAK1 in IL24:IL20RA:JAK1:IL20RB is phosphorylated" xref: reactome:R-HSA-8987141 "IL20:IL20RA:JAK1:IL20RB:p-JAK3,p-JAK2:STAT3 phosphorylates STAT3" xref: reactome:R-HSA-8987150 "IL24:IL20RA:p-JAK1:IL20RB:STAT1,STAT3 phosphorylates STAT1 or STAT3" xref: reactome:R-HSA-8987179 "IL20:IL20RA:JAK1:IL20RB:JAK2,JAK3 phosphorylates JAK2,JAK3" xref: reactome:R-HSA-8987202 "IFNL1:IFNLR1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2" xref: reactome:R-HSA-8987255 "IL26:IL10RB:p-TYK2:IL20RA:p-JAK1:STAT1,STAT3 phosphorylates STAT1,STAT3" is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004715 name: non-membrane spanning protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-tyrosine = ADP + protein L-tyrosine phosphate by a non-membrane spanning protein." [EC:2.7.10.2] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] xref: EC:2.7.10.2 xref: MetaCyc:2.7.10.2-RXN xref: reactome:R-HSA-1112602 "Tyrosine phosphorylation of STAT1, STAT3 by IL6 receptor" xref: reactome:R-HSA-1112703 "PTPN11 is phosphorylated" xref: reactome:R-HSA-1168423 "JAK2 phosphorylation of IRS-1/2" xref: reactome:R-HSA-1168459 "Lyn activates ERK" xref: reactome:R-HSA-1168767 "JAK2 phosphorylates STAT1/STAT3" xref: reactome:R-HSA-1295519 "IL7R is phosphorylated on Y499" xref: reactome:R-HSA-1369115 "SHP2 is phosphorylated" xref: reactome:R-HSA-432148 "Fgr may phosphorylate p38 MAPK" xref: reactome:R-HSA-437936 "p-Y348-SYK phosphorylates VAV family" xref: reactome:R-HSA-453200 "SYK autophosphorylates" xref: reactome:R-HSA-6786095 "JAK1 phosphorylates STAT3,STAT6" xref: reactome:R-HSA-6786096 "IL4R, IL2RG, JAK1 in IL4-bound IL4R1:JAK1 are phosphorylated" xref: reactome:R-HSA-6788582 "STAT1,STAT3,STAT6 phosphorylation" xref: reactome:R-HSA-879910 "JAK2 is phosphorylated, activated" xref: reactome:R-HSA-8871373 "BMX phosphorylates RUFY1" is_a: GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0004716 name: obsolete signal transducer, downstream of receptor, with protein tyrosine kinase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein tyrosine kinase activity" EXACT [] synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] xref: EC:2.7.10 is_obsolete: true [Term] id: GO:0004717 name: obsolete focal adhesion kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. synonym: "FAK" EXACT [] synonym: "focal adhesion kinase activity" EXACT [] is_obsolete: true replaced_by: GO:0004713 [Term] id: GO:0004719 name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] xref: EC:2.1.1.77 xref: MetaCyc:2.1.1.77-RXN xref: reactome:R-HSA-5676966 "PCMT1 transfers CH3 from AdoMet to isoAsp to form MetAsp" is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0004720 name: protein-lysine 6-oxidase activity namespace: molecular_function alt_id: GO:0018056 def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + hydrogen peroxide." [EC:1.4.3.13] synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] xref: EC:1.4.3.13 xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN xref: reactome:R-HSA-2002466 "Formation of allysine by LOX" xref: reactome:R-HSA-2129375 "Elastin cross-linking by lysyl oxidase" xref: reactome:R-HSA-2395340 "Formation of hydroxyallysine by LOX" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004721 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: MetaCyc:3.1.3.16-RXN xref: reactome:R-HSA-112383 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" xref: reactome:R-HSA-113503 "PP2A mediated localization of RB1 protein in chromatin" xref: reactome:R-HSA-1363274 "Dephosphorylation of p107 (RBL1) by PP2A" xref: reactome:R-HSA-1363276 "Dephosphorylation of p130 (RBL2) by PP2A" xref: reactome:R-HSA-167072 "Hypophosphorylation of RNA Pol II CTD by FCP1P protein" xref: reactome:R-HSA-170153 "Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases" xref: reactome:R-HSA-170158 "Dephosphorylation of nuclear Cyclin A:phospho-Cdc2 complexes" xref: reactome:R-HSA-170161 "Dephosphorylation of cytoplasmic Cyclin B1/B2:phospho-Cdc2 (Thr 14, Tyr 15) complexes by CDC25B" xref: reactome:R-HSA-174110 "Cdc25A mediated dephosphorylation of Cyclin A:phospho-Cdk2" xref: reactome:R-HSA-174124 "Dephosphorylation of phospho-Cdh1" xref: reactome:R-HSA-178178 "PP1 dephosphorylates TGFBR1" xref: reactome:R-HSA-2529015 "Dephosphorylation of CK2-modified condensin I" xref: reactome:R-HSA-69199 "Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A" is_a: GO:0016791 ! phosphatase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004722 name: protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0000158 alt_id: GO:0000163 alt_id: GO:0008598 alt_id: GO:0008600 alt_id: GO:0015071 alt_id: GO:0030357 alt_id: GO:0030358 alt_id: GO:0030360 alt_id: GO:0030361 def: "Catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf] synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: reactome:R-HSA-1295632 "PPA2A dephosphorylates SPRY2" xref: reactome:R-HSA-163568 "phosphorylated perilipin + H2O -> perilipin + orthophosphate" xref: reactome:R-HSA-1638821 "PP2A-B56 dephosphorylates centromeric cohesin" xref: reactome:R-HSA-199425 "PHLPP dephosphorylates S473 in AKT" xref: reactome:R-HSA-199959 "ERKs are inactivated by protein phosphatase 2A" xref: reactome:R-HSA-201787 "PPP3 complex dephosphorylates DARPP-32 on Thr34" xref: reactome:R-HSA-201790 "DARPP-32 is dephosphorylated on Thr75 by PP2A" xref: reactome:R-HSA-209055 "PPM1A dephosphorylates nuclear SMAD2/3" xref: reactome:R-HSA-2187401 "MTMR4 dephosphorylates SMAD2/3" xref: reactome:R-HSA-2995388 "PP2A dephosphorylates BANF1" xref: reactome:R-HSA-3002811 "Myosin phosphatase dephosphorylates PLK1" xref: reactome:R-HSA-3601585 "PP2A dephosphorylates AXIN, APC and CTNNB1 in the destruction complex" xref: reactome:R-HSA-380949 "AMPK is dephosphorylated" xref: reactome:R-HSA-4088141 "PP2A-PPP2R2A dephosphorylates FOXM1" xref: reactome:R-HSA-429730 "multiphospho-CERT:PPM1L:VAPA/B + 3 H2O => CERT:PPM1L:VAPA/B + 3 orthophosphate" xref: reactome:R-HSA-4419948 "CTDNEP1:CNEP1R1 dephosphorylates LPIN" xref: reactome:R-HSA-5672957 "PP2A dephosphorylates KSR1" xref: reactome:R-HSA-5672961 "PP2A dephosphorylates inactive RAFs" xref: reactome:R-HSA-5675431 "PP2A dephosphorylates RAF1" xref: reactome:R-HSA-5675433 "PP5 dephosphorylates RAF1 S338" xref: reactome:R-HSA-5679206 "MTMR14, MTMR3 dephosphorylate PI3P" xref: reactome:R-HSA-5683405 "PPP5C dephosphorylates TP53BP1" xref: reactome:R-HSA-5687758 "PPP4C:PPP4R2 dephosphorylates RPA2" xref: reactome:R-HSA-5692754 "CDC14A,B dephosphorylate p-3S,T MAPK6" xref: reactome:R-HSA-5693153 "PPM1K dephosphorylates p-BCKDH" xref: reactome:R-HSA-5694421 "PP6 dephosphorylates SEC24" xref: reactome:R-HSA-6792863 "PP2A-PP2R5C dephosphorylates MDM2" xref: reactome:R-HSA-6811504 "AKT1 dephosphorylation by PP2A-B56-beta,gamma" xref: reactome:R-HSA-6814559 "Pre-snRNA is elongated and capped with 7-methylguanosine" xref: reactome:R-HSA-74948 "PP2A dephosphorylates p-RHO to RHO" xref: reactome:R-HSA-8948139 "p-S13-FUNDC1 is dephosphorylated by PGAM5" xref: reactome:R-HSA-9619430 "PPM1E dephosphorylates CAMK4" xref: reactome:R-HSA-9619449 "PPM1F dephosphorylates p-T286-CaMKII" xref: reactome:R-HSA-9619467 "PPM1F dephosphorylates CAMK1" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004723 name: calcium-dependent protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0008596 def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of calcium ions." [EC:3.1.3.16, GOC:mah] synonym: "calcineurin" NARROW [] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] xref: reactome:R-HSA-2025882 "Calcineurin dephosphorylates NFATC1,2,3" is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004724 name: magnesium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine phosphate + H2O = protein serine + phosphate; and protein threonine phosphate + H2O = protein threonine + phosphate. These reactions require the presence of magnesium." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004725 name: protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PTPase activity" EXACT [EC:3.1.3.48] synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] xref: EC:3.1.3.48 xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN xref: reactome:R-HSA-1169188 "SHP1 (PTPN6) dephosphorylates JAK2" xref: reactome:R-HSA-1169192 "PTP1B dephosphorylates GHR" xref: reactome:R-HSA-1169210 "PTP1B dephosphorylates JAK2" xref: reactome:R-HSA-1549564 "PPTN11 dephosphorylates SPRY2" xref: reactome:R-HSA-202214 "Dephosphorylation of Lck-pY505 by CD45" xref: reactome:R-HSA-203797 "ERKs are inactivated by dual-specific phosphatases (DUSPs)" xref: reactome:R-HSA-377643 "Dephosphorylation of inactive SRC by PTPB1" xref: reactome:R-HSA-389758 "Dephosphorylation of CD3-zeta by PD-1 bound phosphatases" xref: reactome:R-HSA-391868 "Dephosphorylation of NCAM1 bound pFyn" xref: reactome:R-HSA-445089 "Dephosphorylation of pL1 (Y1176)" xref: reactome:R-HSA-5683967 "EYA1-4 dephosphorylates tyrosine Y142 of H2AFX" xref: reactome:R-HSA-6807008 "PTPRJ dephosphorylates MET" xref: reactome:R-HSA-6807027 "PTPN1 and PTPN2 dephosphorylate MET" xref: reactome:R-HSA-74733 "Insulin receptor de-phosphorylation" xref: reactome:R-HSA-74747 "Dephosphorylation of p-Y-IRS1,p-Y-IRS2" xref: reactome:R-HSA-74748 "De-phosphorylation of p-Y427-SHC1" xref: reactome:R-HSA-877308 "Dephosphorylation of JAKs by PTPs" xref: reactome:R-HSA-8849435 "PTPN1 dephosphorylates PTK6" xref: reactome:R-HSA-8852200 "Inactivation of LCK by PTPN22" xref: reactome:R-HSA-8855381 "PTPN22 dephosphorylates ZAP70" xref: reactome:R-HSA-8863804 "PTPN12 dephosphorylates ERBB2 on tyrosine Y1248" xref: reactome:R-HSA-8864029 "PTPN12 dephosphorylates EGFR at Y1148 (Y1172)" xref: reactome:R-HSA-8864036 "PTPN12 dephosphorylates PDGFRB at Y1021" xref: reactome:R-HSA-8864125 "PTPN18 dephosphorylates ERBB2 at Y1196, Y1112 and Y1248" xref: reactome:R-HSA-8867047 "PTPN3 dephosphorylates EPS15" xref: reactome:R-HSA-8937767 "PTPN11 dephosphorylates RUNX1" xref: reactome:R-HSA-914036 "SHP1 and SHP2 dephosphorylate Y628 of IL3RB" xref: reactome:R-HSA-9603719 "Protein tyrosine phosphatases dephosphorylate NTRK3" xref: reactome:R-HSA-997309 "Dephosphorylation of STAT1 by SHP2" xref: reactome:R-HSA-997311 "Dephosphorylation of TYK2 by PTP1B" xref: reactome:R-HSA-997314 "Dephosphorylation of JAK1 by SHP1" xref: reactome:R-HSA-997326 "Dephosphorylation of p-STAT1 dimer by nuclear isoform of TCPTP" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004726 name: non-membrane spanning protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: non-membrane spanning protein tyrosine phosphate + H2O = non-membrane spanning protein tyrosine + phosphate." [EC:3.1.3.48] xref: reactome:R-HSA-177923 "Sustained activation of SRC kinase by SHP2" xref: reactome:R-HSA-177924 "Dephosphorylation of Gab1 by SHP2" xref: reactome:R-HSA-177926 "Dephosphorylation of PAG by SHP2" xref: reactome:R-HSA-177935 "SHP2 dephosphorylates Tyr 992 on EGFR" is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004727 name: prenylated protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004728 name: obsolete signal transducer, downstream of receptor, with protein tyrosine phosphatase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein tyrosine phosphatase activity" EXACT [] synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] is_obsolete: true [Term] id: GO:0004729 name: oxygen-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 3 O(2) + protoporphyrinogen IX = 3 H(2)O(2) + protoporphyrin IX." [EC:1.3.3.4, RHEA:25576] synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] xref: EC:1.3.3.4 xref: KEGG:R03222 xref: MetaCyc:PROTOPORGENOXI-RXN xref: reactome:R-HSA-189423 "PPO oxidises PPGEN9 to PRIN9" xref: RHEA:25576 is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity [Term] id: GO:0004730 name: pseudouridylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + uracil = H(2)O + pseudouridine 5'-phosphate." [EC:4.2.1.70, RHEA:18337] comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine monophosphate synthase activity" EXACT [] synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine-5'-phosphate glycosidase activity" EXACT [] synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] xref: EC:4.2.1.70 xref: KEGG:R01055 xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN xref: RHEA:18337 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004731 name: purine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "PNPase activity" EXACT [EC:2.4.2.1] synonym: "PUNPI" RELATED [EC:2.4.2.1] synonym: "PUNPII" RELATED [EC:2.4.2.1] synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] xref: EC:2.4.2.1 xref: MetaCyc:PNP-RXN xref: reactome:R-HSA-112033 "hypoxanthine + (deoxy)ribose 1-phosphate <=> (deoxy)inosine + orthophosphate (NP)" xref: reactome:R-HSA-112034 "guanine + (deoxy)ribose 1-phosphate <=> (deoxy)guanosine + orthophosphate (NP)" xref: reactome:R-HSA-74242 "(deoxy)inosine + orthophosphate <=> hypoxanthine + (deoxy)ribose 1-phosphate (NP)" xref: reactome:R-HSA-74249 "(deoxy)guanosine + orthophosphate <=> guanine + (deoxy)ribose 1-phosphate (NP)" xref: RHEA:19805 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004732 name: pyridoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + hydrogen peroxide." [EC:1.2.3.8] synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] xref: EC:1.2.3.8 xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN xref: RHEA:23724 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004733 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + hydrogen peroxide." [EC:1.4.3.5] synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: MetaCyc:PMPOXI-RXN xref: reactome:R-HSA-965019 "2xPNPO:2xFMN oxidizes PDXP to PXLP" xref: reactome:R-HSA-965079 "2xPNPO:2xFMN oxidizes PXAP to PXLP" xref: RHEA:15817 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0004734 name: pyrimidodiazepine synthase activity namespace: molecular_function def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: MetaCyc:1.5.4.1-RXN is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] id: GO:0004735 name: pyrroline-5-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] synonym: "P5CR activity" EXACT [EC:1.5.1.2] xref: EC:1.5.1.2 xref: MetaCyc:PYRROLINECARBREDUCT-RXN xref: reactome:R-HSA-6783939 "PYCR2 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: reactome:R-HSA-6783955 "PYCRL decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: reactome:R-HSA-70664 "PYCR1 decamer reduces (S)-1-pyrroline-5-carboxylate to L-Pro" xref: RHEA:14109 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004736 name: pyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + pyruvate = ADP + 2 H(+) + oxaloacetate + phosphate." [EC:6.4.1.1, RHEA:20844] synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] xref: EC:6.4.1.1 xref: KEGG:R00344 xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN xref: reactome:R-HSA-70501 "Pyruvate + CO2 + ATP => ADP + Orthophosphate + Oxaloacetate" xref: RHEA:20844 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0004737 name: pyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] xref: EC:4.1.1.1 xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN xref: RHEA:11628 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004738 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: MetaCyc:PYRUVOXID-RXN xref: MetaCyc:RXN0-1134 xref: reactome:R-HSA-71397 "lipo-PDH decarboxylates PYR to Ac-CoA" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0004739 name: pyruvate dehydrogenase (acetyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] synonym: "PDH" RELATED [EC:1.2.4.1] synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004740 name: pyruvate dehydrogenase (acetyl-transferring) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] synonym: "PDHK" RELATED [EC:2.7.11.2] synonym: "PDK" RELATED [EC:2.7.11.2] synonym: "PDK1" RELATED [EC:2.7.11.2] synonym: "PDK2" RELATED [EC:2.7.11.2] synonym: "PDK3" RELATED [EC:2.7.11.2] synonym: "PDK4" RELATED [EC:2.7.11.2] synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: MetaCyc:2.7.11.2-RXN xref: reactome:R-HSA-203946 "PDK isoforms phosphorylate lipo-PDH" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004741 name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity namespace: molecular_function alt_id: GO:0019906 def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: MetaCyc:3.1.3.43-RXN xref: reactome:R-HSA-204169 "PDP dephosphorylates p-lipo-PDH" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004742 name: dihydrolipoyllysine-residue acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] xref: EC:2.3.1.12 is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004743 name: pyruvate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: MetaCyc:PEPDEPHOS-RXN xref: reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP" xref: Reactome:R-HSA-71670 "phosphoenolpyruvate + ADP => pyruvate + ATP, Homo sapiens" xref: RHEA:18157 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004744 name: retinal isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [RHEA:24124] synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] xref: KEGG:R02126 xref: MetaCyc:RETINAL-ISOMERASE-RXN xref: RHEA:24124 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0004745 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] synonym: "all-trans retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinal reductase activity" BROAD [GOC:ecd, PMID:12036956] synonym: "retinene reductase activity" BROAD [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" BROAD [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] xref: EC:1.1.1.105 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN xref: reactome:R-HSA-2454081 "RDH5 oxidises 11cROL to 11cRAL" xref: reactome:R-HSA-5362518 "RDH10,16,DHRS9,RDHE2 oxidise atROL to atRAL" xref: reactome:R-HSA-5362564 "ADH1A,1C,4 oxidise atROL to atRAL in vitro" xref: reactome:R-HSA-5362721 "RDH5,RDH11 oxidise 11cROL to 11cRAL" xref: RHEA:21284 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004746 name: riboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine + H(+) = 5-amino-6-(D-ribitylamino)uracil + riboflavin." [EC:2.5.1.9, RHEA:20772] synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] synonym: "vitamin B2 synthase activity" EXACT [] xref: EC:2.5.1.9 xref: KEGG:R00066 xref: MetaCyc:RIBOFLAVIN-SYN-RXN xref: RHEA:20772 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004747 name: ribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] xref: EC:2.7.1.15 xref: MetaCyc:RIBOKIN-RXN xref: reactome:R-HSA-8955844 "RBKS phosphorylates ribose to R5P" xref: RHEA:13697 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004748 name: ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor namespace: molecular_function alt_id: GO:0016959 alt_id: GO:0016960 alt_id: GO:0016961 def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] comment: When thioredoxin is substituted for glutaredoxin in the reaction, annotate instead to 'ribonucleoside-diphosphate reductase, glutaredoxin disulfide as acceptor ; GO:0036175'. synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] xref: EC:1.17.4.1 xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN xref: reactome:R-HSA-111751 "RNR (M1M2) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" xref: reactome:R-HSA-111804 "RNR (M1M2B) reduces nucleotide diphosphates to deoxynucleotide diphosphates (thioredoxin)" xref: RHEA:23252 is_a: GO:0061731 ! ribonucleoside-diphosphate reductase activity [Term] id: GO:0004749 name: ribose phosphate diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate + ATP = 5-phospho-alpha-D-ribose 1-diphosphate + AMP + 2 H(+)." [EC:2.7.6.1, RHEA:15609] synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.1 xref: KEGG:R01049 xref: MetaCyc:PRPPSYN-RXN xref: MetaCyc:PWY0-662 xref: reactome:R-HSA-111215 "D-ribose 5-phosphate + 2'-deoxyadenosine 5'-triphosphate (dATP) => 5-Phospho-alpha-D-ribose 1-diphosphate (PRPP) + 2'-deoxyadenosine 5'-monophosphate" xref: reactome:R-HSA-73580 "D-ribose 5-phosphate + ATP => 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) + adenosine 5'-monophosphate" xref: RHEA:15609 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004750 name: ribulose-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1, RHEA:13677] synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] xref: EC:5.1.3.1 xref: KEGG:R01529 xref: MetaCyc:RIBULP3EPIM-RXN xref: reactome:R-HSA-199803 "xylulose 5-phosphate <=> D-ribulose 5-phosphate" xref: reactome:R-HSA-71303 "RPE dimers isomerise RU5P to XY5P" xref: RHEA:13677 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004751 name: ribose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6, RHEA:14657] synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] xref: EC:5.3.1.6 xref: KEGG:R01056 xref: MetaCyc:RIB5PISOM-RXN xref: reactome:R-HSA-177784 "ribose 5-phosphate <=> D-ribulose 5-phosphate" xref: reactome:R-HSA-71306 "D-ribulose 5-phosphate <=> ribose 5-phosphate" xref: RHEA:14657 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004753 name: saccharopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004754 name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH." [EC:1.5.1.7, RHEA:12440] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] xref: EC:1.5.1.7 xref: KEGG:R00715 xref: MetaCyc:1.5.1.7-RXN xref: RHEA:12440 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004755 name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: L-saccharopine + H(2)O + NADP(+) = L-allysine + L-glutamate + H(+) + NADPH." [EC:1.5.1.10, RHEA:10020] synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] xref: EC:1.5.1.10 xref: KEGG:R02315 xref: MetaCyc:RXN3O-127 xref: RHEA:10020 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004756 name: selenide, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + hydrogen selenide = AMP + 3 H(+) + phosphate + selenophosphorate." [EC:2.7.9.3, RHEA:18737] synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] synonym: "selenophosphate synthase activity" EXACT [] synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] xref: EC:2.7.9.3 xref: KEGG:R03595 xref: MetaCyc:2.7.9.3-RXN xref: reactome:R-HSA-8959510 "SEPHS2 phosphorylates H2Se to form SELP" xref: RHEA:18737 xref: UM-BBD_reactionID:r0833 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0004757 name: sepiapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] xref: EC:1.1.1.153 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN xref: reactome:R-HSA-1475414 "PTHP is reduced to BH4 by sepiapterin reductase (SPR)" xref: reactome:R-HSA-1497869 "Salvage - Sepiapterin is reduced to BH2" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004758 name: serine C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + H(+) + palmitoyl-CoA = 3-dehydrosphinganine + CO(2) + CoA." [EC:2.3.1.50, RHEA:14761] synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] synonym: "serine palmitoyltransferase" BROAD [] synonym: "SPT" RELATED [EC:2.3.1.50] xref: EC:2.3.1.50 xref: KEGG:R01281 xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN xref: reactome:R-HSA-428127 "palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2" xref: RHEA:14761 is_a: GO:0016454 ! C-palmitoyltransferase activity [Term] id: GO:0004760 name: serine-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0004761 alt_id: GO:0004762 alt_id: GO:0004763 def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51, RHEA:22852] synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase activity" EXACT [] synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] synonym: "SPT" RELATED [EC:2.6.1.51] xref: EC:2.6.1.51 xref: KEGG:R00585 xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN xref: RHEA:22852 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004764 name: shikimate 3-dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" BROAD [EC:1.1.1.25] synonym: "DHS reductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" BROAD [EC:1.1.1.25] synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) oxidoreductase activity" BROAD [EC:1.1.1.25] xref: EC:1.1.1.25 xref: EC:1.1.1.282 xref: KEGG:R06847 xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN xref: RHEA:17737 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004765 name: shikimate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + shikimate = 3-phosphoshikimate + ADP + 2 H(+)." [EC:2.7.1.71, RHEA:13121] synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] xref: EC:2.7.1.71 xref: KEGG:R02412 xref: MetaCyc:SHIKIMATE-KINASE-RXN xref: RHEA:13121 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004766 name: spermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "SpeE" RELATED [EC:2.5.1.16] synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] xref: EC:2.5.1.16 xref: MetaCyc:SPERMIDINESYN-RXN xref: reactome:R-HSA-351215 "Putrescine + dc-Adenosyl methionine => Spermidine + 5'-methylthioadenosine" xref: RHEA:12721 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: H(2)O + sphingomyelin = ceramide + choline phosphate + H(+)." [EC:3.1.4.12, RHEA:19253] subset: goslim_chembl synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: KEGG:R02541 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: reactome:R-HSA-1605797 "Sphingomyelin phosphodiesterase (SMPD1) hydrolyses sphingomyelin to ceramide (lysosome)" xref: reactome:R-HSA-1606273 "Sphingomyelin phosphodiesterase 2 and 3 (SMPD2 and 3) hydrolyse sphingomyelin to ceramide (plasma membrane)" xref: reactome:R-HSA-1606288 "Sphingomyelin phosphodiesterase 4 (SMPD4) hydrolyses sphingomyelin to ceramide (ER membrane)" xref: reactome:R-HSA-1640164 "Ectonucleotide pyrophosphatase/phosphodiesterase 7 (ENPP7) hydrolyses sphingomyelin" xref: reactome:R-HSA-193706 "Production of ceramide which can activate JNK and other targets" xref: RHEA:19253 is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004768 name: stearoyl-CoA 9-desaturase activity namespace: molecular_function alt_id: GO:0016214 alt_id: GO:0043735 def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] comment: Note that this function was formerly EC:1.14.99.5. synonym: "acyl-CoA desaturase activity" BROAD [EC:1.14.19.1] synonym: "delta(9)-desaturase activity" BROAD [EC:1.14.19.1] synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED [] synonym: "delta9-desaturase activity" BROAD [EC:1.14.19.1] synonym: "fatty acid desaturase activity" BROAD [EC:1.14.19.1] synonym: "stearoyl-CoA desaturase activity" BROAD [] synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] xref: EC:1.14.19.1 xref: MetaCyc:1.14.19.1-RXN xref: reactome:R-HSA-5690565 "SCD desaturates ST-CoA to OLE-CoA" xref: reactome:R-HSA-8847579 "SCD5 desaturates ST-CoA to OLE-CoA" is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0004769 name: steroid delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "steroid D-isomerase activity" EXACT [] synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] xref: EC:5.3.3.1 xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN xref: reactome:R-HSA-193052 "Pregn-5-ene-3,20-dione isomerizes to progesterone" xref: reactome:R-HSA-193073 "DHA isomerizes to 4-Androstene3,17-dione" xref: reactome:R-HSA-193961 "Pregn-5-ene-3,20-dione-17-ol isomerizes to 17-hydroxyprogesterone" xref: reactome:R-HSA-195690 "Zymosterol is isomerized to cholesta-7,24-dien-3beta-ol" xref: reactome:R-HSA-6807052 "EBP isomerizes ZYMSTNL to LTHSOL" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004771 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] subset: goslim_chembl synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: reactome:R-HSA-192417 "Digestion of cholesterol esters by extracellular CEL (bile salt-dependent lipase)" xref: reactome:R-HSA-6813720 "NCEH1 hydrolyzes cholesterol esters" xref: reactome:R-HSA-8865667 "LIPA hydrolyses sterol esters to sterols and fatty acids" is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004772 name: sterol O-acyltransferase activity namespace: molecular_function alt_id: GO:0017066 def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004773 name: steryl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + sulfate." [EC:3.1.6.2] synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulphatase activity" EXACT [] xref: EC:3.1.6.2 xref: MetaCyc:STERYL-SULFATASE-RXN xref: reactome:R-HSA-1606839 "Steryl sulfatase hydrolyses sulfate from steroid sulfates" xref: RHEA:19873 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004774 name: succinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: succinate + CoA + nucleotide triphosphate = nucleotide diphosphate + phosphate + succinyl-CoA." [EC:6.2.1.4, EC:6.2.1.5, GOC:ai] xref: EC:6.2.1.4 xref: RHEA:22120 is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0004775 name: succinate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] synonym: "A-SCS" RELATED [EC:6.2.1.5] synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] xref: EC:6.2.1.5 xref: KEGG:R00405 xref: MetaCyc:SUCCCOASYN-RXN xref: reactome:R-HSA-70997 "ADP + Orthophosphate + Succinyl-CoA <=> ATP + Succinate + CoA" xref: RHEA:17661 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004776 name: succinate-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] synonym: "G-STK" RELATED [EC:6.2.1.4] synonym: "P-enzyme" RELATED [EC:6.2.1.4] synonym: "SCS" RELATED [EC:6.2.1.4] synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] xref: EC:6.2.1.4 xref: KEGG:R00432 xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN xref: reactome:R-HSA-71775 "GDP + Orthophosphate + Succinyl-CoA <=> GTP + Succinate + CoA" xref: RHEA:22120 is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004777 name: succinate-semialdehyde dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0008952 def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] synonym: "succinate semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde dehydrogenase activity" BROAD [GOC:bf] synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinic semialdehyde dehydrogenase activity" BROAD [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN xref: reactome:R-HSA-888548 "Conversion of succinate semialdehyde to succinate" xref: RHEA:13217 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004778 name: succinyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + succinyl-CoA = CoA + H(+) + succinate." [EC:3.1.2.3, RHEA:11516] synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] xref: EC:3.1.2.3 xref: KEGG:R00407 xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN xref: RHEA:11516 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0004779 name: sulfate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] synonym: "sulphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004780 name: sulfate adenylyltransferase (ADP) activity namespace: molecular_function def: "Catalysis of the reaction: ADP + H(+) + sulfate = 5'-adenylyl sulfate + phosphate." [EC:2.7.7.5, RHEA:16529] synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] xref: EC:2.7.7.5 xref: KEGG:R00530 xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN xref: RHEA:16529 is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004781 name: sulfate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + sulfate = diphosphate + adenylylsulfate." [EC:2.7.7.4] synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] xref: EC:2.7.7.4 xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN xref: reactome:R-HSA-174392 "PAPSS1,2 transfer SO4(2-) group to ATP to form APS" xref: RHEA:18133 is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004782 name: sulfinoalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] synonym: "CSAD" RELATED [EC:4.1.1.29] synonym: "CSADCase activity" EXACT [EC:4.1.1.29] synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN xref: reactome:R-HSA-1655443 "CSAD decarboxylates 3-sulfinoalanine to hypotaurine" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004783 name: sulfite reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + 3 NADP+ + 3 H2O = sulfite + 3 NADPH + 3 H+." [EC:1.8.1.2] synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] synonym: "sulphite reductase (NADPH) activity" EXACT [] xref: EC:1.8.1.2 xref: MetaCyc:SULFITE-REDUCT-RXN xref: RHEA:13801 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004784 name: superoxide dismutase activity namespace: molecular_function alt_id: GO:0004785 alt_id: GO:0008382 alt_id: GO:0008383 alt_id: GO:0016954 def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + hydrogen peroxide." [EC:1.15.1.1, GOC:vw, PMID:15064408] synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: MetaCyc:SUPEROX-DISMUT-RXN xref: reactome:R-HSA-1222462 "SodB reduces superoxide to H2O2" xref: reactome:R-HSA-1222469 "SodC reduces superoxide to H2O2" xref: reactome:R-HSA-3299680 "SOD2 catalyzes 2H+ + 2O2.- => O2 + H2O2 (mitochondrial matrix)" xref: reactome:R-HSA-3299682 "SOD3 catalyzes 2H+ + 2O2.- => O2 + H2O2 (extracellular)" xref: reactome:R-HSA-3299691 "SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol)" xref: reactome:R-HSA-3777112 "SOD1 catalyzes 2H+ + O2.- => O2 + H2O2 (mitochondrial intermembrane space)" xref: RHEA:20696 is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0004786 name: obsolete Mn, Fe superoxide dismutase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the function is covered by an existing term. synonym: "Mn, Fe superoxide dismutase" EXACT [] is_obsolete: true consider: GO:0004784 [Term] id: GO:0004787 name: thiamine-pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] synonym: "thiamin pyrophosphatase activity" EXACT [] synonym: "thiamin-pyrophosphatase activity" EXACT [GOC:curators] synonym: "thiamine pyrophosphatase activity" EXACT [] synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "TPPase activity" EXACT [] xref: EC:3.6.1 is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004788 name: thiamine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = AMP + thiamine diphosphate." [EC:2.7.6.2] synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin diphosphokinase activity" EXACT [GOC:curators] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN xref: reactome:R-HSA-196761 "2xTPK1:Mg2+ phosphorylates THMN" xref: RHEA:11576 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004789 name: thiamine-phosphate diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-methyl-5-diphosphomethylpyrimidine + 4-methyl-5-(2-phosphoethyl)-thiazole + H(+) = diphosphate + thiamine phosphate." [EC:2.5.1.3, RHEA:22328] synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] synonym: "thiamin-phosphate diphosphorylase activity" EXACT [GOC:curators] synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] xref: EC:2.5.1.3 xref: KEGG:R03223 xref: MetaCyc:THI-P-SYN-RXN xref: RHEA:22328 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004790 name: thioether S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96, RHEA:19613] synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] xref: EC:2.1.1.96 xref: KEGG:R02572 xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN xref: RHEA:19613 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004791 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP(+) + thioredoxin = H(+) + NADPH + thioredoxin disulfide." [EC:1.8.1.9, RHEA:20345] synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: KEGG:R02016 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: reactome:R-HSA-1222485 "TrxB reactivates TrxA" xref: reactome:R-HSA-3323050 "TXNRD2 catalyzes the reduction of TXN2 by NADPH" xref: reactome:R-HSA-73646 "thioredoxin, oxidized + NADPH + H+ => thioredoxin, reduced + NADP+" xref: reactome:R-HSA-9617735 "TXN disrupts FOXO4 complex with EP300" xref: RHEA:20345 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0004792 name: thiosulfate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen cyanide + thiosulfate = H(+) + sulfite + thiocyanate." [EC:2.8.1.1, RHEA:16881] synonym: "rhodanase activity" EXACT [EC:2.8.1.1] synonym: "rhodanese activity" RELATED [EC:2.8.1.1] synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulphate sulphurtransferase activity" EXACT [] xref: EC:2.8.1.1 xref: KEGG:R01931 xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN xref: reactome:R-HSA-9013198 "TST transfers sulfur from S2O3(2-) to HCN to form HSCN" xref: RHEA:16881 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004793 name: threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] synonym: "L-threonine aldolase activity" EXACT [] xref: EC:4.1.2.5 xref: MetaCyc:THREONINE-ALDOLASE-RXN xref: RHEA:19625 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004794 name: L-threonine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] comment: Note that this function was formerly EC:4.2.1.16. synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] synonym: "threonine ammonia-lyase activity" EXACT [] synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydratase activity" EXACT [] xref: EC:4.3.1.19 xref: MetaCyc:THREDEHYD-RXN xref: RHEA:22108 xref: UM-BBD_reactionID:r0433 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004795 name: threonine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] xref: EC:4.2.3.1 xref: MetaCyc:THRESYN-RXN xref: RHEA:10840 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004796 name: thromboxane-A synthase activity namespace: molecular_function alt_id: GO:0008400 def: "Catalysis of the reaction: prostaglandin H(2) = thromboxane A(2)." [EC:5.3.99.5, RHEA:17137] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] synonym: "cytochrome P450 CYP5" NARROW [] synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] xref: EC:5.3.99.5 xref: KEGG:R02268 xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN xref: reactome:R-HSA-76500 "TBXAS1 isomerises PGH2 to TXA2" xref: RHEA:17137 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004797 name: thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] xref: EC:2.7.1.21 xref: MetaCyc:THYKI-RXN xref: RHEA:19129 is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004798 name: thymidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "dTMP kinase activity" EXACT [] synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] synonym: "TMPK activity" EXACT [EC:2.7.4.9] xref: EC:2.7.4.9 xref: MetaCyc:DTMPKI-RXN xref: RHEA:13517 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0004799 name: thymidylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate." [EC:2.1.1.45, RHEA:12104] synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] xref: EC:2.1.1.45 xref: KEGG:R02101 xref: MetaCyc:THYMIDYLATESYN-RXN xref: reactome:R-HSA-73605 "dUMP + N5,N10-methylene tetrahydrofolate => TMP + dihydrofolate" xref: RHEA:12104 is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0004800 name: thyroxine 5'-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10] comment: Note that this was EC:3.8.1.4. synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10] synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10] synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10] synonym: "outer ring-deiodinating pathway" EXACT [PMID:20403357] synonym: "thyroxine 5' deiodinase activity" EXACT [] synonym: "thyroxine deiodinase activity" BROAD [] synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] xref: EC:1.97.1.10 xref: MetaCyc:THYROXINE-DEIODINASE-RXN xref: reactome:R-HSA-209772 "Thyroxine is deiodinated to triiodothyronine" xref: reactome:R-HSA-350869 "Thyroxine is deiodinated to reverse triiodothyronine (RT3)" xref: RHEA:19745 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004801 name: sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] synonym: "dihydroxyacetone transferase activity" BROAD [EC:2.2.1.2] synonym: "dihydroxyacetonetransferase activity" BROAD [EC:2.2.1.2] synonym: "glycerone transferase activity" BROAD [EC:2.2.1.2] synonym: "transaldolase activity" BROAD [EC:2.2.1.2] xref: EC:2.2.1.2 xref: MetaCyc:TRANSALDOL-RXN xref: reactome:R-HSA-163764 "D-fructose 6-phosphate + D-erythrose 4-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" xref: reactome:R-HSA-71334 "sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate <=> D-erythrose 4-phosphate + D-fructose 6-phosphate" xref: RHEA:17053 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004802 name: transketolase activity namespace: molecular_function def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah] synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1] xref: EC:2.2.1.1 xref: MetaCyc:1TRANSKETO-RXN xref: reactome:R-HSA-163741 "D-glyceraldehyde 3-phosphate + sedoheptulose 7-phosphate<=> xylulose 5-phosphate+ribose 5-phosphate" xref: reactome:R-HSA-163751 "D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate <=> xylulose 5-phosphate + D-erythrose 4-phosphate" xref: reactome:R-HSA-71324 "ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate" xref: reactome:R-HSA-71335 "xylulose 5-phosphate + D-erythrose 4-phosphate <=> D-glyceraldehyde 3-phosphate + D-fructose 6-phosphate" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004803 name: transposase activity namespace: molecular_function alt_id: GO:0004804 def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element." [GOC:bm, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "P-element encoded transposase activity" NARROW [] is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0004805 name: trehalose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose phosphatase activity" EXACT [] synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] xref: EC:3.1.3.12 xref: MetaCyc:TREHALOSEPHOSPHA-RXN xref: RHEA:23420 is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004806 name: triglyceride lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.3] subset: goslim_chembl synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "TAG activity" EXACT [PMID:16054079] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: reactome:R-HSA-1482777 "TAG is hydrolyzed to DAG by PNPLA2/3" xref: reactome:R-HSA-163551 "triacylglycerol + H2O -> diacylglycerol + fatty acid" xref: reactome:R-HSA-5694109 "LIPC dimer hydrolyses TAG to DAG and FA" xref: reactome:R-HSA-8848338 "PNPLA4 hydrolyzes TAG" xref: reactome:R-HSA-8848339 "PNPLA5 hydrolyzes TAG" xref: RHEA:12044 is_a: GO:0016298 ! lipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0004807 name: triose-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1, RHEA:18585] synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] xref: EC:5.3.1.1 xref: KEGG:R01015 xref: MetaCyc:TRIOSEPISOMERIZATION-RXN xref: reactome:R-HSA-70454 "dihydroxyacetone phosphate <=> D-glyceraldehyde 3-phosphate" xref: reactome:R-HSA-70481 "D-glyceraldehyde 3-phosphate <=> dihydroxyacetone phosphate" xref: RHEA:18585 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004808 name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity namespace: molecular_function alt_id: GO:0016425 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing 5-aminomethyl-2-thiouridine = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61, GOC:imk] synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] xref: EC:2.1.1.61 xref: KEGG:R00601 xref: MetaCyc:2.1.1.61-RXN is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004809 name: tRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing guanine = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] xref: reactome:R-HSA-6782416 "TRMT1 (hTRM1) dimethylates guanosine-26 of tRNA(Tyr)" xref: reactome:R-HSA-6786501 "TRMT11:TRMT112 methylates guanosine-10 in tRNA" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0004810 name: tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] xref: EC:2.7.7.25 xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN is_a: GO:1990817 ! RNA adenylyltransferase activity [Term] id: GO:0004812 name: aminoacyl-tRNA ligase activity namespace: molecular_function alt_id: GO:0016876 alt_id: GO:0017100 def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP." [ISBN:0198506732] comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] synonym: "aminoacyl-tRNA synthetase auxiliary protein activity" RELATED [] synonym: "ligase activity, forming aminoacyl-tRNA and related compounds" BROAD [] is_a: GO:0016875 ! ligase activity, forming carbon-oxygen bonds is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0004813 name: alanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine translase activity" EXACT [EC:6.1.1.7] synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-tRNA synthetase activity" EXACT [] synonym: "AlaRS" RELATED [EC:6.1.1.7] synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] xref: EC:6.1.1.7 xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379864 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" xref: reactome:R-HSA-380177 "alanine + tRNA(Ala) + ATP => Ala-tRNA(Ala) + AMP + pyrophosphate" xref: RHEA:12540 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004814 name: arginine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] synonym: "arginine translase activity" EXACT [EC:6.1.1.19] synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-tRNA synthetase activity" EXACT [] synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] xref: EC:6.1.1.19 xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379993 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" xref: reactome:R-HSA-380224 "arginine + tRNA(Arg) + ATP => Arg-tRNA(Arg) + AMP + pyrophosphate" xref: RHEA:20301 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004815 name: aspartate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-tRNA synthetase activity" EXACT [] synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] xref: EC:6.1.1.12 xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379867 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" xref: reactome:R-HSA-380229 "aspartate + tRNA(Asp) + ATP => Asp-tRNA(Asp) + AMP + pyrophosphate" xref: RHEA:19649 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004816 name: asparagine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + ATP + tRNA(Asn) = AMP + Asn-tRNA(Asn) + diphosphate + 2 H(+)." [EC:6.1.1.22, RHEA:11180] synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-tRNA synthetase activity" EXACT [] synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] xref: EC:6.1.1.22 xref: KEGG:R03648 xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379996 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" xref: reactome:R-HSA-380227 "asparagine + tRNA(Asn) + ATP => Asn-tRNA(Asn) + AMP + pyrophosphate" xref: RHEA:11180 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004817 name: cysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-tRNA synthetase activity" EXACT [] synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] xref: EC:6.1.1.16 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379887 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" xref: reactome:R-HSA-380158 "cysteine + tRNA(Cys) + ATP => Cys-tRNA(Cys) + AMP + pyrophosphate" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004818 name: glutamate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] xref: EC:6.1.1.17 xref: MetaCyc:GLURS-RXN xref: reactome:R-HSA-379861 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: reactome:R-HSA-380216 "glutamate + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: RHEA:23540 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004819 name: glutamine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] synonym: "GlnRS" RELATED [EC:6.1.1.18] synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] xref: EC:6.1.1.18 xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379982 "glutamine + tRNA(Gln) + ATP => Gln-tRNA(Gln) + AMP + pyrophosphate" xref: reactome:R-HSA-380241 "glutamine + tRNA(Glu) + ATP => Glu-tRNA(Glu) + AMP + pyrophosphate" xref: RHEA:20121 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004820 name: glycine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.14 xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-380048 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" xref: reactome:R-HSA-380240 "glycine + tRNA(Gly) + ATP => Gly-tRNA(Gly) + AMP + pyrophosphate" xref: RHEA:16013 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004821 name: histidine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] synonym: "histidine translase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-tRNA synthetase activity" EXACT [] synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] xref: EC:6.1.1.21 xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379844 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" xref: reactome:R-HSA-380234 "histidine + tRNA(His) + ATP => His-tRNA(His) + AMP + pyrophosphate" xref: RHEA:17313 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004822 name: isoleucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-isoleucine + ATP + tRNA(Ile) = L-isoleucyl-tRNA(Ile) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.5, RHEA:11060] synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-tRNA synthetase activity" EXACT [] synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] xref: EC:6.1.1.5 xref: KEGG:R03656 xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379893 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" xref: reactome:R-HSA-380176 "isoleucine + tRNA(Ile) + ATP => Ile-tRNA(Ile) + AMP + pyrophosphate" xref: RHEA:11060 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004823 name: leucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H(+) + Leu-tRNA(Leu)." [EC:6.1.1.4, RHEA:11688] synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] synonym: "leucine translase activity" EXACT [EC:6.1.1.4] synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.4 xref: KEGG:R03657 xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379974 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" xref: reactome:R-HSA-380200 "leucine + tRNA(Leu) + ATP => Leu-tRNA(Leu) + AMP + pyrophosphate" xref: RHEA:11688 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004824 name: lysine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] synonym: "lysine translase activity" EXACT [EC:6.1.1.6] synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.6 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-380008 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" xref: reactome:R-HSA-380233 "lysine + tRNA(Lys) + ATP => Lys-tRNA(Lys) + AMP + pyrophosphate" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004825 name: methionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] synonym: "methionine translase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-tRNA synthetase activity" EXACT [] synonym: "MetRS activity" EXACT [EC:6.1.1.10] xref: EC:6.1.1.10 xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379994 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" xref: reactome:R-HSA-380157 "methionine + tRNA(Met) + ATP => Met-tRNA(Met) + AMP + pyrophosphate" xref: RHEA:13481 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004826 name: phenylalanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.20 xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379848 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" xref: reactome:R-HSA-380203 "phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate" xref: RHEA:19413 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004827 name: proline-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] synonym: "proline translase activity" EXACT [EC:6.1.1.15] synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.15 xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379865 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" xref: reactome:R-HSA-380198 "proline + tRNA(Pro) + ATP => Pro-tRNA(Pro) + AMP + pyrophosphate" xref: RHEA:14305 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004828 name: serine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] synonym: "serine translase activity" EXACT [EC:6.1.1.11] synonym: "SerRS activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.11 xref: MetaCyc:SERINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379992 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" xref: reactome:R-HSA-380239 "serine + tRNA(Ser) + ATP => Ser-tRNA(Ser) + AMP + pyrophosphate" xref: RHEA:12292 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004829 name: threonine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] synonym: "threonine translase activity" EXACT [EC:6.1.1.3] synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-tRNA synthetase activity" EXACT [] synonym: "TRS" RELATED [EC:6.1.1.3] xref: EC:6.1.1.3 xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-380002 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" xref: reactome:R-HSA-380201 "threonine + tRNA(Thr) + ATP => Thr-tRNA(Thr) + AMP + pyrophosphate" xref: RHEA:24624 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004830 name: tryptophan-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "TrpRS activity" EXACT [EC:6.1.1.2] synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.2 xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN xref: reactome:R-HSA-379977 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" xref: reactome:R-HSA-380222 "tryptophan + tRNA(Trp) + ATP => Trp-tRNA(Trp) + AMP + pyrophosphate" xref: RHEA:24080 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004831 name: tyrosine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + ATP + tRNA(Tyr) = L-tyrosyl-tRNA(Tyr) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.1, RHEA:10220] synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.1 xref: KEGG:R02918 xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-379980 "tyrosine + tRNA(Tyr) + ATP =>Tyr-tRNA(Tyr) + AMP + pyrophosphate" xref: reactome:R-HSA-380170 "tyrosine + tRNA(Tyr) + ATP => Tyr-tRNA(Tyr) + AMP + pyrophosphate" xref: RHEA:10220 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004832 name: valine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + ATP + tRNA(Val) = L-valyl-tRNA(Val) + AMP + diphosphate + 2 H(+)." [EC:6.1.1.9, RHEA:10704] synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] synonym: "valine translase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.9 xref: KEGG:R03665 xref: MetaCyc:VALINE--TRNA-LIGASE-RXN xref: reactome:R-HSA-380042 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" xref: reactome:R-HSA-380199 "valine + tRNA(Val) + ATP => Val-tRNA(Val) + AMP + pyrophosphate" xref: RHEA:10704 is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004833 name: tryptophan 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0004426 def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] synonym: "TDO" RELATED [EC:1.13.11.11] synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] xref: EC:1.13.11.11 xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN xref: reactome:R-HSA-198563 "IDO1 dioxygenates L-Trp to NFK" xref: reactome:R-HSA-71188 "TDO tetramer dioxygenates L-Trp to NFK" xref: reactome:R-HSA-888614 "IDO2 dioxygenates L-Trp to NFK" xref: RHEA:24536 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004834 name: tryptophan synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [RHEA:10532] synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] xref: EC:4.2.1.20 xref: KEGG:R02722 xref: MetaCyc:TRYPSYN-RXN xref: RHEA:10532 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004835 name: tubulin-tyrosine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] synonym: "TTL activity" EXACT [EC:6.3.2.25] synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: MetaCyc:6.3.2.25-RXN xref: reactome:R-HSA-8955706 "TTL ligates L-Tyr to the carboxy terminus of alpha-tubulin" is_a: GO:0016881 ! acid-amino acid ligase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0004836 name: tyramine-beta hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004837 name: tyrosine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] xref: EC:4.1.1.25 xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN xref: RHEA:14345 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004838 name: L-tyrosine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5] synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5] synonym: "TyrAT activity" RELATED [EC:2.6.1.5] synonym: "tyrosine aminotransferase activity" BROAD [] synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5] xref: EC:2.6.1.5 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: reactome:R-HSA-517444 "p-hydroxyphenylpyruvate + glutamate <=> tyrosine + alpha-ketoglutarate" xref: reactome:R-HSA-71155 "tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate" is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] id: GO:0004839 name: ubiquitin activating enzyme activity namespace: molecular_function def: "Catalysis of the reaction: E1 + ubiquitin + ATP--> E1-ubiquitin + AMP + PPi, where the E1-ubiquitin linkage is a thioester bond between the C-terminal glycine of Ub and a sulfhydryl side group of an E1 cysteine residue. This is the first step in a cascade of reactions in which ubiquitin is ultimately added to a protein substrate." [GOC:BioGRID, http://www.bostonbiochem.com/E-301.html, Wikipedia:Ubiquitin-activating_enzyme] comment: The ubiquitin activating enzyme catalyzes a ligation reaction. synonym: "E1 ubiquitin-activating enzyme" EXACT [http://enzyme.expasy.org/EC/6.2.1.45] xref: EC:6.2.1.45 xref: reactome:R-HSA-8852132 "Ub-Cys632-UBA1 adenylates ubiquitin in the cytosol" xref: reactome:R-HSA-8852133 "UBA1 conjugates ubiquitin to UBA1 in the cytosol" xref: reactome:R-HSA-8852134 "UBA1 adenylates ubiquitin in the cytosol" xref: reactome:R-HSA-8865050 "Ub-Cys625-UBA6 adenylates ubiquitin in the cytosol" xref: reactome:R-HSA-8865090 "UBA6 adenylates ubiquitin in the cytosol" xref: reactome:R-HSA-8865098 "UBA6 conjugates ubiquitin to UBA6 in the cytosol" is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0004842 name: ubiquitin-protein transferase activity namespace: molecular_function alt_id: GO:0004840 alt_id: GO:0004841 def: "Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages." [GOC:BioGRID, GOC:jh2, PMID:9635407] synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tb] synonym: "E2" RELATED [] synonym: "E3" RELATED [] synonym: "ubiquitin conjugating enzyme activity" NARROW [] synonym: "ubiquitin ligase activity" NARROW [] synonym: "ubiquitin protein ligase activity" NARROW [] synonym: "ubiquitin protein-ligase activity" NARROW [] synonym: "ubiquitin-conjugating enzyme activity" NARROW [] xref: KEGG:R03876 xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: reactome:R-HSA-1169394 "ISGylation of IRF3" xref: reactome:R-HSA-1169395 "ISGylation of viral protein NS1" xref: reactome:R-HSA-1169397 "Activation of ISG15 by UBA7 E1 ligase" xref: reactome:R-HSA-1169398 "ISGylation of host protein filamin B" xref: reactome:R-HSA-1169402 "ISGylation of E2 conjugating enzymes" xref: reactome:R-HSA-1169405 "ISGylation of protein phosphatase 1 beta (PP2CB)" xref: reactome:R-HSA-1169406 "ISGylation of host proteins" xref: reactome:R-HSA-1234163 "Cytosolic VBC complex ubiquitinylates hydroxyprolyl-HIF-alpha" xref: reactome:R-HSA-1234172 "Nuclear VBC complex ubiquitinylates HIF-alpha" xref: reactome:R-HSA-1253282 "ERBB4 ubiquitination by WWP1/ITCH" xref: reactome:R-HSA-1358789 "Self-ubiquitination of RNF41" xref: reactome:R-HSA-1358790 "RNF41 ubiquitinates ERBB3" xref: reactome:R-HSA-1358792 "RNF41 ubiquitinates activated ERBB3" xref: reactome:R-HSA-1363331 "Ubiquitination of p130 (RBL2) by SCF (Skp2)" xref: reactome:R-HSA-168915 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" xref: reactome:R-HSA-173542 "SMURF2 ubiquitinates SMAD2" xref: reactome:R-HSA-173545 "Ubiquitin-dependent degradation of the SMAD complex terminates TGF-beta signaling" xref: reactome:R-HSA-174057 "Multiubiquitination of APC/C-associated Cdh1" xref: reactome:R-HSA-174104 "Ubiquitination of Cyclin A by APC/C:Cdc20 complex" xref: reactome:R-HSA-174144 "Ubiquitination of Securin by phospho-APC/C:Cdc20 complex" xref: reactome:R-HSA-174159 "Ubiquitination of Emi1 by SCF-beta-TrCP" xref: reactome:R-HSA-174195 "Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex" xref: reactome:R-HSA-174227 "Ubiquitination of Cyclin B by phospho-APC/C:Cdc20 complex" xref: reactome:R-HSA-179417 "Multiubiquitination of Nek2A" xref: reactome:R-HSA-180540 "Multi-ubiquitination of APOBEC3G" xref: reactome:R-HSA-180597 "Ubiquitination of CD4 by Vpu:CD4:beta-TrCP:SKP1 complex" xref: reactome:R-HSA-182986 "CBL-mediated ubiquitination of CIN85" xref: reactome:R-HSA-182993 "Ubiquitination of stimulated EGFR (CBL)" xref: reactome:R-HSA-183036 "Ubiquitination of stimulated EGFR (CBL:GRB2)" xref: reactome:R-HSA-183051 "CBL ubiquitinates Sprouty" xref: reactome:R-HSA-183084 "CBL escapes CDC42-mediated inhibition by down-regulating the adaptor molecule Beta-Pix" xref: reactome:R-HSA-183089 "CBL binds and ubiquitinates phosphorylated Sprouty" xref: reactome:R-HSA-1852623 "Ubiquitination of NICD1 by FBWX7" xref: reactome:R-HSA-187575 "Ubiquitination of phospho-p27/p21" xref: reactome:R-HSA-1912357 "ITCH ubiquitinates DTX" xref: reactome:R-HSA-1912386 "Ubiquitination of NOTCH1 by ITCH in the absence of ligand" xref: reactome:R-HSA-1918092 "CHIP (STUB1) mediates ubiquitination of ERBB2" xref: reactome:R-HSA-1918095 "CUL5 mediates ubiquitination of ERBB2" xref: reactome:R-HSA-1977296 "NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer" xref: reactome:R-HSA-1980074 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1" xref: reactome:R-HSA-1980118 "ARRB mediates NOTCH1 ubiquitination" xref: reactome:R-HSA-201425 "Ubiquitin-dependent degradation of the Smad complex terminates BMP2 signalling" xref: reactome:R-HSA-202453 "Auto-ubiquitination of TRAF6" xref: reactome:R-HSA-202534 "Ubiquitination of NEMO by TRAF6" xref: reactome:R-HSA-205118 "TRAF6 polyubiquitinates NRIF" xref: reactome:R-HSA-209063 "Beta-TrCP ubiquitinates NFKB p50:p65:phospho IKBA complex" xref: reactome:R-HSA-211734 "Ubiquitination of PAK-2p34" xref: reactome:R-HSA-2169050 "SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7" xref: reactome:R-HSA-2172172 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH2" xref: reactome:R-HSA-2179276 "SMURF2 monoubiquitinates SMAD3" xref: reactome:R-HSA-2186747 "Ubiquitination of SKI/SKIL by RNF111/SMURF2" xref: reactome:R-HSA-2186785 "RNF111 ubiquitinates SMAD7" xref: reactome:R-HSA-2187368 "STUB1 (CHIP) ubiquitinates SMAD3" xref: reactome:R-HSA-2213017 "Auto-ubiquitination of TRAF3" xref: reactome:R-HSA-264444 "Autoubiquitination of phospho-COP1(Ser-387 )" xref: reactome:R-HSA-2682349 "RAF1:SGK:TSC22D3:WPP ubiquitinates SCNN channels" xref: reactome:R-HSA-2730904 "Auto-ubiquitination of TRAF6" xref: reactome:R-HSA-2737728 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD domain mutants" xref: reactome:R-HSA-2769007 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 PEST domain mutants" xref: reactome:R-HSA-2900765 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH1 HD+PEST domain mutants" xref: reactome:R-HSA-3000335 "SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA" xref: reactome:R-HSA-3134804 "STING ubiquitination by TRIM32 or TRIM56" xref: reactome:R-HSA-3134946 "DDX41 ubiquitination by TRIM21" xref: reactome:R-HSA-3249386 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:dsDNA:ZBP1:TBK1" xref: reactome:R-HSA-3780995 "NHLRC1 mediated ubiquitination of EPM2A (laforin) and PPP1RC3 (PTG) associated with glycogen-GYG2" xref: reactome:R-HSA-3781009 "NHLRC1 mediated ubiquitination of EPM2A and PPP1RC3 associated with glycogen-GYG1" xref: reactome:R-HSA-3788724 "Cdh1:APC/C ubiquitinates EHMT1 and EHMT2" xref: reactome:R-HSA-400267 "BTRC:CUL1:SKP1 (SCF-beta-TrCP1) ubiquitinylates PER proteins" xref: reactome:R-HSA-4332236 "CBL neddylates TGFBR2" xref: reactome:R-HSA-446877 "TRAF6 is K63 poly-ubiquitinated" xref: reactome:R-HSA-450358 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR stimulation" xref: reactome:R-HSA-451418 "Pellino ubiquitinates IRAK1" xref: reactome:R-HSA-5205682 "Parkin promotes the ubiquitination of mitochondrial substrates" xref: reactome:R-HSA-5357757 "BIRC(cIAP1/2) ubiquitinates RIPK1" xref: reactome:R-HSA-5362412 "SYVN1 ubiquitinates Hh C-terminal fragments" xref: reactome:R-HSA-5483238 "Hh processing variants are ubiquitinated" xref: reactome:R-HSA-5607725 "SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP" xref: reactome:R-HSA-5607728 "beta-TRCP ubiquitinates IkB-alpha in p-S32,33-IkB-alpha:NF-kB complex" xref: reactome:R-HSA-5607756 "TRAF6 oligomer autoubiquitinates" xref: reactome:R-HSA-5607757 "K63polyUb-TRAF6 ubiquitinates TAK1" xref: reactome:R-HSA-5610742 "SCF(beta-TrCP) ubiquitinates p-GLI1" xref: reactome:R-HSA-5610745 "SCF(beta-TrCP) ubiquitinates p-GLI2" xref: reactome:R-HSA-5610746 "SCF(beta-TrCP) ubiquitinates p-GLI3" xref: reactome:R-HSA-5652009 "RAD18:UBE2B or RBX1:CUL4:DDB1:DTL monoubiquitinates PCNA" xref: reactome:R-HSA-5655170 "RCHY1 monoubiquitinates POLH" xref: reactome:R-HSA-5660753 "SIAH1:UBE2L6:Ubiquitin ubiquitinates SNCA" xref: reactome:R-HSA-5667107 "SIAH1, SIAH2 ubiquitinate SNCAIP" xref: reactome:R-HSA-5667111 "PARK2 K63-Ubiquitinates SNCAIP" xref: reactome:R-HSA-5668454 "K63polyUb-cIAP1,2 ubiquitinates TRAF3" xref: reactome:R-HSA-5668534 "cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK" xref: reactome:R-HSA-5675470 "BIRC2/3 (cIAP1/2) is autoubiquitinated" xref: reactome:R-HSA-5684250 "SCF betaTrCP ubiquitinates NFKB p105 within p-S927, S932-NFkB p105:TPL2:ABIN2" xref: reactome:R-HSA-5691108 "SKP1:FBXL5:CUL1:NEDD8 ubiquitinylates IREB2" xref: reactome:R-HSA-5693108 "TNFAIP3 (A20) ubiquitinates RIPK1 with K48-linked Ub chains" xref: reactome:R-HSA-69598 "Ubiquitination of phosphorylated Cdc25A" xref: reactome:R-HSA-741386 "RIP2 induces K63-linked ubiquitination of NEMO" xref: reactome:R-HSA-75824 "Ubiquitination of Cyclin D1" xref: reactome:R-HSA-870449 "TRIM33 monoubiquitinates SMAD4" xref: reactome:R-HSA-8948709 "DTX4 ubiquitinates p-S172-TBK1 within NLRP4:DTX4:STING:TBK1:IRF3" xref: reactome:R-HSA-8956106 "VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha" xref: reactome:R-HSA-9013069 "Ubiquitination of DLL/JAG ligands upon binding to NOTCH3" xref: reactome:R-HSA-9013974 "Auto-ubiquitination of TRAF3 within activated TLR3 complex" xref: reactome:R-HSA-9014342 "K63-linked ubiquitination of RIP1 bound to the activated TLR complex" xref: reactome:R-HSA-918224 "DDX58 is K63 polyubiquitinated" xref: reactome:R-HSA-936412 "RNF125 mediated ubiquitination of DDX58, IFIH1 and MADS" xref: reactome:R-HSA-936942 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2" xref: reactome:R-HSA-936986 "Activated TRAF6 synthesizes unanchored polyubiquitin chains" xref: reactome:R-HSA-9628444 "Activated TRAF6 synthesizes unanchored polyubiquitin chains upon TLR3 stimulation" xref: reactome:R-HSA-975118 "TRAF6 ubiquitinqtes IRF7 in a K63-dependent manner following TLR7/8 or 9 stimulation" xref: reactome:R-HSA-975147 "Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane" xref: reactome:R-HSA-983140 "Transfer of Ub from E2 to substrate and release of E2" xref: reactome:R-HSA-983153 "E1 mediated ubiquitin activation" xref: reactome:R-HSA-983156 "Polyubiquitination of substrate" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0004843 name: thiol-dependent ubiquitin-specific protease activity namespace: molecular_function def: "Catalysis of the thiol-dependent hydrolysis of a peptide bond formed by the C-terminal glycine of ubiquitin and another protein." [GOC:jh2, ISBN:0120793709] synonym: "deubiquitinase" EXACT [GOC:vw, PMID:19261746] synonym: "deubiquitinase activity" NARROW [GOC:bf] synonym: "deubiquitinating enzyme" NARROW [PMID:19188440] synonym: "deubiquitylase" EXACT [GOC:vw, PMID:15657442] synonym: "ubiquitin C-terminal hydrolase activity" EXACT [EC:3.4.19.12] synonym: "ubiquitin hydrolase activity" BROAD [GOC:rl] synonym: "ubiquitin-specific protease activity" BROAD [] synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] xref: reactome:R-HSA-1358795 "Deubiquitination of RNF41 by P-USP8" xref: reactome:R-HSA-2179291 "UCHL5, USP15 deubiquitinate TGFBR1" xref: reactome:R-HSA-3215295 "USP7 deubiquitinates MDM2" xref: reactome:R-HSA-3215310 "USP7 deubiquitinates TP53 and counteracts MDM2" xref: reactome:R-HSA-4641236 "USP8 deubiquitinates FZD to potentiate WNT signaling" xref: reactome:R-HSA-5653770 "USP10 deubiquitinates monoUb:K164,ISG:K164,ISG:K168-PCNA" xref: reactome:R-HSA-5655466 "USP1:WDR48 deubiquitinates monoUb:K164-PCNA" xref: reactome:R-HSA-5696465 "USP45 deubiquitinates ERCC1" xref: reactome:R-HSA-6782069 "UVSSA:USP7 deubiquitinates ERCC6" xref: reactome:R-HSA-6786171 "FANCD2 deubiquitination by USP1:WDR48" xref: reactome:R-HSA-6807118 "USP7 deubiquitinates monoubiquitinated PTEN" xref: reactome:R-HSA-6807206 "USP13 and OTUD3 deubiquitinate PTEN" xref: reactome:R-HSA-8853503 "UCHL3,USP7,USP9X cleaves RPS27A yielding ubiquitin" xref: reactome:R-HSA-8853514 "UCHL3,USP7,USP9X cleaves UBA52 yielding ubiquitin" xref: reactome:R-HSA-8853515 "OTULIN,USP5 cleaves UBC yielding ubiquitin" xref: reactome:R-HSA-8853529 "OTULIN,USP5 cleaves UBB yielding ubiquitin" xref: reactome:R-HSA-8875443 "USP8 deubiquitinates LRIG1" xref: reactome:R-HSA-8986083 "USP33 deubiquitinates ROBO1" is_a: GO:0036459 ! thiol-dependent ubiquitinyl hydrolase activity [Term] id: GO:0004844 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, GOC:pr, PMID:9224623] synonym: "uracil-DNA glycosylase activity" EXACT [] xref: reactome:R-HSA-110215 "Cleavage of uracil by UNG glycosylase" xref: reactome:R-HSA-110217 "Cleavage of 5-hydroxyluracil by UNG glycosylase" is_a: GO:0097506 ! deaminated base DNA N-glycosylase activity [Term] id: GO:0004845 name: uracil phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + UMP = 5-phospho-alpha-D-ribose 1-diphosphate + uracil." [EC:2.4.2.9, RHEA:13017] synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UPRTase activity" EXACT [EC:2.4.2.9] synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] xref: EC:2.4.2.9 xref: KEGG:R00966 xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN xref: RHEA:13017 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004846 name: urate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + hydrogen peroxide." [EC:1.7.3.3] synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] synonym: "uricase activity" EXACT [EC:1.7.3.3] synonym: "uricase II activity" NARROW [EC:1.7.3.3] xref: EC:1.7.3.3 xref: MetaCyc:URATE-OXIDASE-RXN xref: RHEA:21368 xref: UM-BBD_reactionID:r1322 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0004847 name: urea carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + bicarbonate + urea = ADP + 2 H(+) + phosphate + urea-1-carboxylate." [EC:6.3.4.6, RHEA:20896] synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "UALase activity" EXACT [EC:6.3.4.6] synonym: "UCA activity" EXACT [EC:6.3.4.6] synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] xref: EC:6.3.4.6 xref: KEGG:R00774 xref: MetaCyc:UREA-CARBOXYLASE-RXN xref: RHEA:20896 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004848 name: ureidoglycolate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + H(2)O + 2 H(+) = CO(2) + glyoxylate + 2 NH(4)(+)." [EC:3.5.3.19, RHEA:19809] comment: Take care to annotate to the reaction, not simply the enzyme name. The name "ureidoglycolate hydrolase" has variously been used to refer to two distinctly different enzymes. Both enzymes act on ureidoglycolate and produce glyoxylate, but the mechanism and reaction products are different. The "ureidoglycolate hydrolase" listed in the Enzyme commission (EC) is a ureidoglycolate amidohydrolase, releasing ammonia, (EC 3.5.3.19, GO:0004848). The "ureidoglycolate hydrolase" characterized in PMID:3915539 (published prior to the EC designation of EC 3.5.3.19) is a ureidoglycolate lyase, releasing urea (EC 4.3.2.3, GO:0050385). The inappropriate labelling of ureidoglycolate lyase as EC 3.5.3.19 has caused much confusion in the literature (see PMID:24107613). Take care to correctly annotate based on the reaction products, rather than name. synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19] xref: EC:3.5.3.19 xref: KEGG:R00469 xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN xref: RHEA:19809 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004849 name: uridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] synonym: "uridine kinase reaction" EXACT [] synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] xref: EC:2.7.1.48 xref: MetaCyc:URIDINEKIN-RXN xref: reactome:R-HSA-8954327 "UCKL1 phosphorylates urindine, cytidine" xref: RHEA:16825 is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004850 name: uridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] synonym: "UPase activity" EXACT [EC:2.4.2.3] synonym: "UPH" RELATED [EC:2.4.2.3] synonym: "UrdPase activity" EXACT [EC:2.4.2.3] synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] xref: EC:2.4.2.3 xref: MetaCyc:URPHOS-RXN xref: reactome:R-HSA-74372 "uracil + (deoxy)ribose 1-phosphate <=> (deoxy)uridine + orthophosphate [UPP]" xref: reactome:R-HSA-74376 "(deoxy)uridine + orthophosphate <=> uracil + (deoxy)ribose 1-phosphate (UPP)" xref: RHEA:24388 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004851 name: uroporphyrin-III C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "CobA" RELATED [EC:2.1.1.107] synonym: "CysG" RELATED [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "SirA" RELATED [EC:2.1.1.107] synonym: "SUMT activity" EXACT [EC:2.1.1.107] synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004852 name: uroporphyrinogen-III synthase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylbilane = H(2)O + uroporphyrinogen III." [EC:4.2.1.75, RHEA:18965] synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] xref: EC:4.2.1.75 xref: KEGG:R03165 xref: MetaCyc:UROGENIIISYN-RXN xref: reactome:R-HSA-189488 "UROS transforms HMB to URO3" xref: RHEA:18965 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004853 name: uroporphyrinogen decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] xref: EC:4.1.1.37 xref: MetaCyc:UROGENDECARBOX-RXN xref: reactome:R-HSA-189425 "UROD decarboxylates URO3 to COPRO3" xref: reactome:R-HSA-190182 "UROD decarboxylates URO1 to COPRO1" xref: RHEA:19865 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004854 name: xanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: MetaCyc:RXN0-901 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0004855 name: xanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + hydrogen peroxide." [EC:1.17.3.2] synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] xref: EC:1.17.3.2 xref: MetaCyc:XANTHINE-OXIDASE-RXN xref: reactome:R-HSA-74247 "Hypoxanthine + H2O + O2 => Xanthine + H2O2" xref: reactome:R-HSA-74258 "Xanthine + H2O + O2 => Urate + H2O2" xref: RHEA:21132 xref: UM-BBD_enzymeID:e0781 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0004856 name: xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylulose + ATP = D-xylulose 5-phosphate + ADP + 2 H(+)." [EC:2.7.1.17, RHEA:10964] synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] xref: EC:2.7.1.17 xref: KEGG:R01639 xref: MetaCyc:XYLULOKIN-RXN xref: reactome:R-HSA-5662466 "XYLB phosphorylates D-xylulose" xref: RHEA:10964 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004857 name: enzyme inhibitor activity namespace: molecular_function alt_id: GO:0048551 def: "Binds to and stops, prevents or reduces the activity of an enzyme." [GOC:ai, GOC:ebc] synonym: "metalloenzyme inhibitor activity" NARROW [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0004858 name: dUTP pyrophosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0004859 name: phospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] is_a: GO:0055102 ! lipase inhibitor activity [Term] id: GO:0004860 name: protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019210 ! kinase inhibitor activity is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0004861 name: cyclin-dependent protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cyclin-dependent protein serine/threonine kinase." [GOC:mah, GOC:pr] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] synonym: "cyclin-dependent protein kinase inhibitor activity" BROAD [] xref: reactome:R-HSA-69562 "Inactivation of Cyclin E:Cdk2 complexes by p27/p21" is_a: GO:0016538 ! cyclin-dependent protein serine/threonine kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0004862 name: cAMP-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] xref: reactome:R-HSA-180073 "DARPP-32 phosphorylated on Thr75 binds to PKA, inhibiting its function" is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0004864 name: protein phosphatase inhibitor activity namespace: molecular_function alt_id: GO:1990681 def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai] synonym: "phosphoprotein phosphatase inhibitor activity" EXACT [GOC:curators] synonym: "protein phosphatase 2 inhibitor activity" NARROW [GOC:dph] synonym: "protein phosphatase type 2A inhibitor activity" NARROW [] is_a: GO:0019212 ! phosphatase inhibitor activity is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0004865 name: protein serine/threonine phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:dph, GOC:tb] is_a: GO:0004864 ! protein phosphatase inhibitor activity [Term] id: GO:0004866 name: endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] synonym: "alpha-2 macroglobulin" RELATED [] synonym: "endoproteinase inhibitor" NARROW [] synonym: "proteinase inhibitor" NARROW [] is_a: GO:0030414 ! peptidase inhibitor activity is_a: GO:0061135 ! endopeptidase regulator activity [Term] id: GO:0004867 name: serine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] synonym: "serine protease inhibitor activity" NARROW [] synonym: "serine proteinase inhibitor activity" NARROW [] synonym: "serpin activity" NARROW [] xref: reactome:R-HSA-158795 "fibrin multimer, crosslinked:tissue plasminogen activator (one-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (one-chain):plasminogen activator inhibitor 1" xref: reactome:R-HSA-158800 "fibrin multimer, crosslinked:tissue plasminogen activator (two-chain) + plasminogen activator inhibitor 1 -> fibrin multimer, crosslinked:tissue plasminogen activator (two-chain):plasminogen activator inhibitor 1" xref: reactome:R-HSA-158893 "alpha-2-antiplasmin + plasmin -> alpha-2-antiplasmin:plasmin" xref: reactome:R-HSA-159001 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 2 (PAI-2) -> PAI-2:urokinase plasminogen activator (two-chain):uPAR" xref: reactome:R-HSA-159005 "urokinase plasminogen activator (two-chain):uPAR + plasminogen activator inhibitor 1 (PAI-1) -> PAI-1:urokinase plasminogen activator (two-chain):uPAR" is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0004868 name: obsolete serpin namespace: molecular_function def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "serpin" EXACT [] is_obsolete: true consider: GO:0004867 [Term] id: GO:0004869 name: cysteine-type endopeptidase inhibitor activity namespace: molecular_function alt_id: GO:0004870 def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] synonym: "cystatin" NARROW [GOC:jl] synonym: "cysteine protease inhibitor activity" NARROW [GOC:dph, GOC:tb] synonym: "thiol protease inhibitor" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0004871 name: obsolete signal transducer activity namespace: molecular_function alt_id: GO:0005062 alt_id: GO:0009369 alt_id: GO:0009370 def: "OBSOLETE. Conveys a signal across a cell to trigger a change in cell function or state. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response." [GOC:go_curators] comment: This term was obsoleted because it was not clearly defined and is not a useful grouping term, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity" NARROW [] synonym: "quorum sensing response regulator activity" NARROW [] synonym: "quorum sensing signal generator activity" NARROW [] is_obsolete: true [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "Receiving an asialoglycoprotein, and delivering the asialoglycoprotein into the cell via endocytosis. An asialoglycoprotein is a plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate groups has been removed. The asialoglycoprotein receptor recognizes the terminal galactose and N-acetylgalactosamine units of the asialoglycoprotein, the receptor-ligand complex is internalized and transported to a sorting organelle where disassociation occurs before the receptor is recycled to the cell membrane." [GOC:bf, PMID:11278827, PMID:7624395, Wikipedia:Asialoglycoprotein] subset: goslim_chembl is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0004874 name: obsolete aryl hydrocarbon receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an aryl hydrocarbon and transmitting the signal to initiate a change in cell activity. The aryl hydrocarbon receptor is a ligand-activated transcription factor which translocates to the nucleus to activate transcription upon ligand-binding." [GOC:ai, PMID:1325649, PMID:7493958, Wikipedia:Aryl_hydrocarbon_receptor] comment: This term was obsoleted because it represents a gene product, see https://github.com/geneontology/go-ontology/issues/16733 is_obsolete: true [Term] id: GO:0004875 name: complement receptor activity namespace: molecular_function alt_id: GO:0004942 def: "Combining with any component or product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:pg, GOC:signaling, ISBN:0781735149, PMID:11884446] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. synonym: "anaphylatoxin receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0004876 name: complement component C3a receptor activity namespace: molecular_function alt_id: GO:0004943 def: "Combining with the C3a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] synonym: "C3a anaphylatoxin receptor activity" RELATED [] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004877 name: complement component C3b receptor activity namespace: molecular_function def: "Combining with the C3b product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004878 name: complement component C5a receptor activity namespace: molecular_function alt_id: GO:0004944 def: "Combining with the C5a product of the complement cascade and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah, GOC:pg, GOC:signaling, ISBN:0781735149] synonym: "C5a anaphylatoxin receptor activity" RELATED [] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004879 name: nuclear receptor activity namespace: molecular_function alt_id: GO:0003708 alt_id: GO:0004880 alt_id: GO:0004882 alt_id: GO:0004884 alt_id: GO:0004886 alt_id: GO:0004887 alt_id: GO:0008434 alt_id: GO:0038050 alt_id: GO:0038051 alt_id: GO:0038052 def: "Combining with a signal and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, GOC:txnOH] comment: GO:0004879 is intended for annotation of nuclear receptors that regulate transcription by binding directly to DNA. When the nuclear receptor functions by binding to other transcription factors or transcription factor complexes, consider instead annotating to 'nuclear receptor transcription coactivator activity ; GO:0030374'. synonym: "1,25-(OH)2D3 receptor activity" NARROW [Wikipedia:Calcitriol] synonym: "9-cis retinoic acid receptor activity" NARROW [] synonym: "androgen receptor activity" NARROW [] synonym: "calcitriol receptor activity" NARROW [] synonym: "ecdysteroid hormone receptor activity" NARROW [] synonym: "estrogen nuclear receptor activity" NARROW [GOC:bf] synonym: "glucocorticoid receptor activity" NARROW [GOC:bf] synonym: "juvenile hormone receptor activity" NARROW [] synonym: "ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity" EXACT [] synonym: "ligand-dependent nuclear receptor activity" RELATED [GOC:bf] synonym: "ligand-dependent transcription factor activity" RELATED [GOC:bf] synonym: "nuclear hormone receptor" NARROW [] synonym: "nuclear receptor activity" RELATED [GOC:bf] synonym: "retinoic acid receptor activity" NARROW [] synonym: "retinoid-X receptor activity" NARROW [GOC:bf] synonym: "RNA polymerase II transcription factor activity, estrogen-activated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, glucocorticoid-activated sequence-specific DNA binding" NARROW [] synonym: "RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding" EXACT [] synonym: "RXR" NARROW [] synonym: "thyroid hormone receptor activity" NARROW [] synonym: "vitamin A receptor activity" NARROW [] synonym: "vitamin D receptor activity" NARROW [] synonym: "vitamin D3 receptor activity" NARROW [GOC:bf, Wikipedia:Calcitriol_receptor] is_a: GO:0000981 ! DNA-binding transcription factor activity, RNA polymerase II-specific is_a: GO:0038023 ! signaling receptor activity is_a: GO:0098531 ! ligand-activated transcription factor activity [Term] id: GO:0004883 name: glucocorticoid receptor activity namespace: molecular_function def: "Combining with a glucocorticoid and transmitting the signal within the cell trigger a change in cell activity or function." [GOC:signaling, PMID:17689856, PMID:20920967] comment: If the mechanism by which a glucocorticoid receptor functions is known, consider instead annotating to the child terms 'glucocorticoid-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038050' or 'glucocorticoid-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038051'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0004888 name: transmembrane signaling receptor activity namespace: molecular_function alt_id: GO:0004926 alt_id: GO:0099600 def: "Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction." [GOC:go_curators, Wikipedia:Transmembrane_receptor] comment: This term includes intracellular membrane receptors, e.g. IP3 triggered release of Ca2+ from intracellular stores. synonym: "transmembrane receptor activity" BROAD [GOC:bf, GOC:signaling] synonym: "transmembrane signalling receptor activity" EXACT [GOC:mah] xref: reactome:R-HSA-193672 "Sphingomyelinase is activated by the NGF:p75NTR complex" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0004890 name: GABA-A receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. synonym: "ionotropic GABA receptor activity" EXACT [GOC:bf] is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004892 name: obsolete B cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "B cell receptor activity" EXACT [] is_obsolete: true consider: GO:0003823 [Term] id: GO:0004894 name: obsolete T cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. synonym: "T cell receptor activity" EXACT [] is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0004895 name: cell adhesion receptor activity namespace: molecular_function def: "The binding by a cell-adhesion protein on the cell surface to an extracellular matrix component, to mediate adhesion of the cell to the external substrate or to another cell and to initiate intracellular signaling. Cell adhesion receptors include integrins and cadherins." [GOC:BHF-UCL, Wikipedia:Cell_adhesion] comment: Reinstated term, see https://github.com/geneontology/go-ontology/issues/15237 is_a: GO:0038023 ! signaling receptor activity is_a: GO:0098631 ! cell adhesion mediator activity [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function alt_id: GO:0004907 def: "Combining with a cytokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [http://wiki.geneontology.org/index.php/Why_isn%27t_interleukin_in_GO%3F] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0004897 name: ciliary neurotrophic factor receptor activity namespace: molecular_function def: "Combining with ciliary neurotrophic factor (CNTF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CNTF receptor activity" EXACT [GOC:mah] synonym: "gp130" RELATED [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004898 name: obsolete gp130 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product. synonym: "gp130" EXACT [] is_obsolete: true consider: GO:0004897 consider: GO:0004915 consider: GO:0004921 [Term] id: GO:0004900 name: erythropoietin receptor activity namespace: molecular_function def: "Combining with erythropoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004901 name: granulocyte macrophage colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030525 def: "Combining with granulocyte macrophage colony-stimulating factor (GM-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CSF-2 receptor activity" EXACT [GOC:bf] synonym: "CSF2R" RELATED [GOC:bf] synonym: "GM-CSF receptor activity" EXACT [] synonym: "GMC-SF receptor activity" EXACT [] synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004902 name: granulocyte colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030524 def: "Combining with granulocyte colony-stimulating factor (G-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "CSF3R" RELATED [GOC:bf] synonym: "G-CSF receptor activity" EXACT [GOC:bf] synonym: "granulocyte colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004903 name: growth hormone receptor activity namespace: molecular_function def: "Combining with a growth hormone and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004904 name: interferon receptor activity namespace: molecular_function def: "Combining with an interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:9607096] synonym: "IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004905 name: type I interferon receptor activity namespace: molecular_function def: "Combining with a type I interferon and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:signaling, ISBN:0126896631, PMID:15546383, PMID:16681834, PR:000025848] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] synonym: "interferon-delta receptor activity" NARROW [] synonym: "interferon-epsilon receptor activity" NARROW [] synonym: "interferon-kappa receptor activity" NARROW [] synonym: "interferon-omega receptor activity" NARROW [] synonym: "interferon-tau receptor activity" NARROW [] synonym: "interferon-zeta receptor activity" NARROW [] synonym: "type I IFN receptor activity" EXACT [GOC:mah] is_a: GO:0004904 ! interferon receptor activity [Term] id: GO:0004906 name: interferon-gamma receptor activity namespace: molecular_function def: "Combining with interferon-gamma (a type II interferon) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:ai, GOC:signaling, ISBN:0126896631, PMID:15546383] synonym: "IFN-gamma receptor activity" EXACT [GOC:mah] synonym: "IFNG receptor activity" EXACT [GOC:mah] synonym: "type II interferon receptor activity" BROAD [] is_a: GO:0004904 ! interferon receptor activity [Term] id: GO:0004908 name: interleukin-1 receptor activity namespace: molecular_function def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] synonym: "IL-1 receptor activity" EXACT [] synonym: "IL-1R" EXACT [] xref: Wikipedia:Interleukin-1_receptor is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004909 name: interleukin-1, type I, activating receptor activity namespace: molecular_function alt_id: GO:0019967 def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828] synonym: "IL-1 type I, activating binding" EXACT [] synonym: "IL-1 type I, activating receptor" EXACT [] synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 type I receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, type I, activating binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004910 name: interleukin-1, type II, blocking receptor activity namespace: molecular_function alt_id: GO:0019968 def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828] synonym: "IL-1 type II, blocking binding" EXACT [] synonym: "IL-1 type II, blocking receptor" EXACT [] synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 type II receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, type II, blocking binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004911 name: interleukin-2 receptor activity namespace: molecular_function def: "Combining with interleukin-2 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-2 receptor activity" EXACT [GOC:mah] synonym: "IL-2R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004912 name: interleukin-3 receptor activity namespace: molecular_function def: "Combining with interleukin-3 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-3 receptor activity" EXACT [GOC:mah] synonym: "IL-3R" EXACT [] xref: Wikipedia:Interleukin-3_receptor is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004913 name: interleukin-4 receptor activity namespace: molecular_function def: "Combining with interleukin-4 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-4 receptor activity" EXACT [GOC:mah] synonym: "IL-4R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004914 name: interleukin-5 receptor activity namespace: molecular_function def: "Combining with interleukin-5 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-5 receptor activity" EXACT [GOC:mah] synonym: "IL-5R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004915 name: interleukin-6 receptor activity namespace: molecular_function def: "Combining with interleukin-6 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "gp130" RELATED [] synonym: "IL-6 receptor activity" EXACT [GOC:mah] synonym: "IL-6R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004917 name: interleukin-7 receptor activity namespace: molecular_function def: "Combining with interleukin-7 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-7 receptor activity" EXACT [GOC:mah] synonym: "IL-7R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004918 name: interleukin-8 receptor activity namespace: molecular_function def: "Combining with interleukin-8 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-8 receptor activity" EXACT [GOC:mah] synonym: "IL-8R" EXACT [] is_a: GO:0016494 ! C-X-C chemokine receptor activity [Term] id: GO:0004919 name: interleukin-9 receptor activity namespace: molecular_function def: "Combining with interleukin-9 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-9 receptor activity" EXACT [GOC:mah] synonym: "IL-9R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004920 name: interleukin-10 receptor activity namespace: molecular_function def: "Combining with interleukin-10 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-10 receptor activity" EXACT [GOC:mah] synonym: "IL-10R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004921 name: interleukin-11 receptor activity namespace: molecular_function def: "Combining with interleukin-11 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "gp130" RELATED [] synonym: "IL-11 receptor activity" EXACT [GOC:mah] synonym: "IL-11R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004923 name: leukemia inhibitory factor receptor activity namespace: molecular_function alt_id: GO:0004899 def: "Combining with leukemia inhibitory factor (LIF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:bf, GOC:mah, GOC:signaling] synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah] synonym: "LIF receptor activity" EXACT [GOC:mah] is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity [Term] id: GO:0004924 name: oncostatin-M receptor activity namespace: molecular_function def: "Combining with oncostatin-M and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004927 name: obsolete sevenless receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "sevenless receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0004888 consider: GO:0008288 [Term] id: GO:0004928 name: obsolete frizzled receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "frizzled receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0042813 consider: GO:0016055 [Term] id: GO:0004929 name: obsolete frizzled-2 receptor activity namespace: molecular_function def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. synonym: "frizzled-2 receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0042813 consider: GO:0007223 [Term] id: GO:0004930 name: G protein-coupled receptor activity namespace: molecular_function alt_id: GO:0001622 alt_id: GO:0001623 alt_id: GO:0001624 alt_id: GO:0001625 alt_id: GO:0016526 def: "Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] subset: goslim_chembl synonym: "EBV-induced receptor" NARROW [] synonym: "Epstein-Barr Virus-induced receptor activity" NARROW [] synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" NARROW [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "Mas proto-oncogene receptor activity" NARROW [] synonym: "orphan G protein coupled receptor activity" NARROW [] synonym: "orphan G-protein coupled receptor activity" NARROW [] synonym: "orphan GPCR activity" NARROW [] synonym: "RDC1 receptor activity" NARROW [] synonym: "receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "SREB receptor" NARROW [] synonym: "super conserved receptor expressed in brain receptor activity" NARROW [] xref: reactome:R-HSA-114552 "G12/13 activation by PAR" xref: reactome:R-HSA-114558 "Gq activation by PAR" xref: reactome:R-HSA-167408 "The high affinity receptor complex binds to G-protein" xref: Wikipedia:GPCR is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0004931 name: extracellularly ATP-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when ATP is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:bf, GOC:mah, PMID:9755289] comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. synonym: "P2X receptor" RELATED [PMID:9755289] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] xref: reactome:R-HSA-877187 "P2X7 mediates loss of intracellular K+" is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0035381 ! ATP-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004932 name: mating-type factor pheromone receptor activity namespace: molecular_function def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph, GOC:vw] is_a: GO:0008528 ! G protein-coupled peptide receptor activity is_a: GO:0016503 ! pheromone receptor activity [Term] id: GO:0004933 name: mating-type a-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity [Term] id: GO:0004934 name: mating-type alpha-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity is_a: GO:0036318 ! peptide pheromone receptor activity [Term] id: GO:0004935 name: adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine and transmitting the signal across the membrane by activating the alpha-subunit of an associated heterotrimeric G-protein complex." [GOC:bf, GOC:mah, IUPHAR_GPCR:1274] synonym: "adrenoceptor activity" EXACT [] xref: Wikipedia:Adrenergic_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity [Term] id: GO:0004936 name: alpha-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004937 name: alpha1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha1 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004938 name: alpha2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha2 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004939 name: beta-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "beta adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenergic receptor activity [Term] id: GO:0004940 name: beta1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta1 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004941 name: beta2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta2 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004945 name: angiotensin type II receptor activity namespace: molecular_function def: "An angiotensin receptor activity that acts via Gi protein coupling and cGMP (NO) generation, and may also act via additional signaling mechanisms." [GOC:mah, PMID:10977869] is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0004946 name: bombesin receptor activity namespace: molecular_function def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004947 name: bradykinin receptor activity namespace: molecular_function def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004948 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:21649645] is_a: GO:0097642 ! calcitonin family receptor activity [Term] id: GO:0004949 name: cannabinoid receptor activity namespace: molecular_function def: "Combining with a cannabinoid to initiate a change in cell activity. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids." [GOC:dph, IUPHAR_GPCR:1279, Wikipedia:Cannabinoid] synonym: "cannaboid receptor" EXACT [] synonym: "endocannabinoid receptor activity" NARROW [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004950 name: chemokine receptor activity namespace: molecular_function def: "Combining with a chemokine, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, GOC:signaling, http://en.wikipedia.org/wiki/Chemokine, IUPHAR_GPCR:1280, PMID:12183377, PMID:8662823] is_a: GO:0001637 ! G protein-coupled chemoattractant receptor activity is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004951 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone." [GOC:signaling, PMID:9835394] synonym: "CCK receptor activity" EXACT [PR:000005110, Wikipedia:Cholecystokinin] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004952 name: dopamine neurotransmitter receptor activity namespace: molecular_function def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0004953 name: icosanoid receptor activity namespace: molecular_function def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] synonym: "eicosanoid receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004954 name: prostanoid receptor activity namespace: molecular_function def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732] is_a: GO:0004953 ! icosanoid receptor activity [Term] id: GO:0004955 name: prostaglandin receptor activity namespace: molecular_function def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004956 name: prostaglandin D receptor activity namespace: molecular_function def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGD receptor activity" RELATED [] synonym: "PGD(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004957 name: prostaglandin E receptor activity namespace: molecular_function def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGE receptor activity" RELATED [] synonym: "PGE(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004958 name: prostaglandin F receptor activity namespace: molecular_function def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGF receptor activity" RELATED [] synonym: "PGF(2-alpha) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004960 name: thromboxane receptor activity namespace: molecular_function def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732] synonym: "TXA receptor activity" EXACT [] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004961 name: thromboxane A2 receptor activity namespace: molecular_function def: "Combining with thromboxane A2 (TXA(2)) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:signaling, ISBN:0198506732] synonym: "TXA(2) receptor activity" EXACT [] synonym: "TXA2 receptor activity" EXACT [PMID:15242977] is_a: GO:0004960 ! thromboxane receptor activity [Term] id: GO:0004962 name: endothelin receptor activity namespace: molecular_function alt_id: GO:0001599 alt_id: GO:0001600 def: "Combining with endothelin and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, GOC:signaling, IUPHAR_GPCR:1283, IUPHAR_RECEPTOR:2263, IUPHAR_RECEPTOR:2265] synonym: "endothelin-A receptor activity" NARROW [GOC:bf, PMID:8582288] synonym: "endothelin-B receptor activity" NARROW [GOC:bf, PMID:8582288] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004963 name: follicle-stimulating hormone receptor activity namespace: molecular_function def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "follicle stimulating hormone receptor activity" EXACT [] synonym: "FSH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004964 name: luteinizing hormone receptor activity namespace: molecular_function alt_id: GO:0004976 def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732, PMID:18848524, PMID:1922095] synonym: "LH receptor" EXACT [PMID:18848524] synonym: "LHR" EXACT [PMID:18848524] synonym: "lutropin receptor" EXACT [ISBN:0198506732] synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004965 name: G protein-coupled GABA receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:ai, GOC:bf, IUPHAR_RECEPTOR:1276, Wikipedia:GABAB_receptor] synonym: "G-protein coupled GABA receptor activity" EXACT [] synonym: "GABA-B receptor activity" RELATED [GOC:bf] synonym: "metabotropic GABA receptor" RELATED [Wikipedia:GABAB_receptor] is_a: GO:0016917 ! GABA receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004966 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004967 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:mah, GOC:signaling, PMID:22438981] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004968 name: gonadotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus." [GOC:mah] synonym: "GnRH receptor activity" EXACT [] synonym: "gonadotrophin-releasing hormone receptor activity" EXACT [GOC:dph] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004969 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004970 name: ionotropic glutamate receptor activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [ISBN:0198506732] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. is_a: GO:0008066 ! glutamate receptor activity is_a: GO:0022824 ! transmitter-gated ion channel activity [Term] id: GO:0004971 name: AMPA glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity" EXACT [] synonym: "AMPA receptor activity" EXACT [] is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004972 name: NMDA glutamate receptor activity namespace: molecular_function def: "An cation channel that opens in response to binding by extracellular glutmate, but only if glycine is also bound and the membrane is depolarized. Voltage gating is indirect, due to ejection of bound magnesium from the pore at permissive voltages." [GOC:mah, PMID:10049997] comment: The name of this receptor comes from its selective activation by N-methyl-D-aspartate (NMDA). Note that this term represents an activity and not a gene product. synonym: "N-methyl-D-aspartate selective glutamate receptor activity" EXACT [] synonym: "NMDA receptor" EXACT [] xref: Wikipedia:NMDA_receptor is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0022843 ! voltage-gated cation channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0004973 name: obsolete N-methyl-D-aspartate receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "N-methyl-D-aspartate receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0004974 name: leukotriene receptor activity namespace: molecular_function def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine." [GOC:ai, ISBN:0198506732] is_a: GO:0004953 ! icosanoid receptor activity [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004978 name: corticotropin receptor activity namespace: molecular_function def: "Combining with corticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] synonym: "adrenocorticotropin receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004979 name: beta-endorphin receptor activity namespace: molecular_function def: "Combining with beta-endorphin, and transmitting the signal across the membrane by activating an associated G-protein. Beta-endorphin is a peptide, 31 amino acids long, resulting from processing of the precursor proopiomelanocortin (POMC)." [GOC:ai, GOC:bf, Wikipedia:Beta-endorphin] synonym: "mu-opioid receptor activity" RELATED [GOC:bf] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0004985 ! opioid receptor activity is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004980 name: melanocyte-stimulating hormone receptor activity namespace: molecular_function def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459] synonym: "melanocyte stimulating hormone receptor activity" EXACT [] synonym: "melanophore-stimulating hormone receptor activity" EXACT [] synonym: "MSH receptor activity" BROAD [] synonym: "MSHR activity" BROAD [] is_a: GO:0004977 ! melanocortin receptor activity [Term] id: GO:0004982 name: N-formyl peptide receptor activity namespace: molecular_function def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] synonym: "Fmet-leu-phe receptor" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004983 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004984 name: olfactory receptor activity namespace: molecular_function def: "Combining with an odorant and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity in response to detection of smell." [GOC:bf, GOC:dph, GOC:sart, PMID:19135896, PMID:21041441] synonym: "odorant receptor activity" EXACT [PMID:19135896, PMID:21041441] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0004985 name: opioid receptor activity namespace: molecular_function def: "Combining with an opioid (any narcotic derived from or resembling opium), and transmitting the signal across the membrane by activating an associated G-protein." [CHEBI:60598, GOC:ai, GOC:bf, PMID:20494127] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004986 name: obsolete delta-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of delta-opioid receptors, including the activity of enkephalins as ligands." [IUPHAR_RECEPTOR:317, PMID:10471416] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "delta-opioid receptor activity" EXACT [] xref: Wikipedia:Delta_Opioid_receptor is_obsolete: true consider: GO:0038046 [Term] id: GO:0004987 name: obsolete kappa-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of kappa-opioid receptors, including high affinity for dynorphins." [IUPHAR_RECEPTOR:318] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "kappa-opioid receptor activity" EXACT [] xref: Wikipedia:Kappa_Opioid_receptor is_obsolete: true consider: GO:0038048 [Term] id: GO:0004988 name: obsolete mu-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of mu-opioid receptors, including high affinity for enkephalins and beta-endorphin but low affinity for dynorphins." [IUPHAR_RECEPTOR:319] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "mu-opioid receptor activity" EXACT [] xref: Wikipedia:Mu_Opioid_receptor is_obsolete: true consider: GO:0004979 consider: GO:0038046 consider: GO:0038047 [Term] id: GO:0004989 name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [CHEBI:17134, GOC:ai] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0004990 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0004991 name: parathyroid hormone receptor activity namespace: molecular_function def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004992 name: platelet activating factor receptor activity namespace: molecular_function def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] synonym: "PAF receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004993 name: G protein-coupled serotonin receptor activity namespace: molecular_function alt_id: GO:0001585 alt_id: GO:0016609 def: "Combining with the biogenic amine serotonin and transmitting the signal across the membrane by activating an associated G-protein. Serotonin (5-hydroxytryptamine) is a neurotransmitter and hormone found in vertebrates and invertebrates." [CHEBI:28790, GOC:ai] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] synonym: "G protein coupled serotonin receptor activity" EXACT [] synonym: "G-protein coupled serotonin receptor activity" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity is_a: GO:0099589 ! serotonin receptor activity [Term] id: GO:0004994 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity. Somatostatin is a peptide hormone that regulates the endocrine system by signaling via G protein-coupled somatostatin receptors. Somatostatin has two active forms produced by proteolytic cleavage: a 14 amino acid peptide (SST-14) and a 28 amino acid peptide (SST-28)." [GOC:ai, GOC:bf, Wikipedia:Somatostatin] synonym: "GHIH receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "growth hormone-inhibiting hormone receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "somatotrophin release inhibiting factor receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SRIF receptor activity" EXACT [Wikipedia:Somatostatin] synonym: "SST receptor activity" EXACT [Wikipedia:Somatostatin] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004995 name: tachykinin receptor activity namespace: molecular_function def: "Combining with a tachykinin neuropeptide and transmitting the signal across the membrane by activating an associated G-protein." [GOC:ai, GOC:bf, PMID:7639617, Wikipedia:Tachykinin] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004996 name: thyroid-stimulating hormone receptor activity namespace: molecular_function def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "thyroid stimulating hormone receptor activity" EXACT [] synonym: "thyrotropin receptor" EXACT [] synonym: "TSH receptor activity" EXACT [] xref: Wikipedia:Thyrotropin_receptor is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004997 name: thyrotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0004998 name: transferrin receptor activity namespace: molecular_function def: "Combining selectively with transferrin, and delivering transferrin into the cell via endocytosis. Transferrin is a major iron carrier protein in vertebrates." [GOC:bf, PMID:2678449, PMID:3011819] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0004999 name: vasoactive intestinal polypeptide receptor activity namespace: molecular_function def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function alt_id: GO:0016931 def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] synonym: "vasopressin activated calcium mobilizing receptor activity" NARROW [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0005001 name: transmembrane receptor protein tyrosine phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity [Term] id: GO:0005003 name: ephrin receptor activity namespace: molecular_function def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "Eph receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005004 name: GPI-linked ephrin receptor activity namespace: molecular_function def: "Combining with a GPI-anchored ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "GPI-linked Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005005 name: transmembrane-ephrin receptor activity namespace: molecular_function def: "Combining with a transmembrane ephrin to initiate a change in cell activity." [GOC:mah, PMID:9530499] synonym: "transmembrane-Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005006 name: epidermal growth factor-activated receptor activity namespace: molecular_function alt_id: GO:0005023 def: "Combining with an epidermal growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:bf] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand EGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "EGF receptor activity" EXACT [] synonym: "EGFR" EXACT [] synonym: "epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "TGF-alpha receptor activity" EXACT [] synonym: "transforming growth factor-alpha receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005007 name: fibroblast growth factor-activated receptor activity namespace: molecular_function def: "Combining with a fibroblast growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand FGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "FGF receptor activity" EXACT [] synonym: "FGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "FGFR" EXACT [] synonym: "fibroblast growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005008 name: hepatocyte growth factor-activated receptor activity namespace: molecular_function def: "Combining with hepatocyte growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand HGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "hepatocyte growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "HGF receptor activity" EXACT [] synonym: "HGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005009 name: insulin-activated receptor activity namespace: molecular_function def: "Combining with insulin and transmitting the signal across the plasma membrane to initiate a change in cell activity." [ISBN:0198506732] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand insulin. For receptors that bind other extracellular ligands, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "insulin receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0005010 name: insulin-like growth factor-activated receptor activity namespace: molecular_function def: "Combining with insulin-like growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand IGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "IGF receptor activity" EXACT [] synonym: "IGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "insulin-like growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005011 name: macrophage colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with macrophage colony-stimulating factor (M-CSF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:mah, GOC:signaling] synonym: "CSF-1" NARROW [] synonym: "Fms" NARROW [] synonym: "M-CSF receptor activity" EXACT [GOC:bf] synonym: "macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005012 name: obsolete Neu/ErbB-2 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of receptor rather than an activity. synonym: "Neu/ErbB-2 receptor activity" EXACT [] is_obsolete: true consider: GO:0043125 [Term] id: GO:0005013 name: obsolete neurotrophin TRK receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRK receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0019838 consider: GO:0043121 [Term] id: GO:0005014 name: obsolete neurotrophin TRKA receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKA receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 consider: GO:0048406 [Term] id: GO:0005015 name: obsolete neurotrophin TRKB receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKB receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 consider: GO:0048403 [Term] id: GO:0005016 name: obsolete neurotrophin TRKC receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. synonym: "neurotrophin TRKC receptor activity" EXACT [] is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0043121 [Term] id: GO:0005017 name: platelet-derived growth factor-activated receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand PDGF. For receptors that bind other growth factors, consider annotating to other terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "PDGF receptor activity" EXACT [] synonym: "PDGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "PDGFR activity" EXACT [] synonym: "platelet-derived growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005018 name: platelet-derived growth factor alpha-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "alphaPDGF receptor activity" EXACT [PMID:10372961] synonym: "PDGF alpha-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity [Term] id: GO:0005019 name: platelet-derived growth factor beta-receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity." [PMID:1657917] synonym: "betaPDGF receptor activity" RELATED [PMID:10372961] synonym: "PDGF beta-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor-activated receptor activity [Term] id: GO:0005020 name: stem cell factor receptor activity namespace: molecular_function def: "Combining with stem cell factor (SCF) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate. Stem cell factor is a cytokine that stimulates mast cell growth and differentiation." [GOC:jl, GOC:signaling, PMID:10698217] synonym: "KIT" RELATED [PR:000009345] synonym: "KIT ligand receptor activity" EXACT [PR:000009345] synonym: "KL receptor activity" EXACT [PR:000009345] synonym: "SCF receptor activity" EXACT [PR:000009345] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005021 name: vascular endothelial growth factor-activated receptor activity namespace: molecular_function def: "Combining with a vascular endothelial growth factor (VEGF) and transmitting the signal across the plasma membrane to initiate a change in cell activity." [GOC:mah, GOC:signaling] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand VEGF. For receptors that bind other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "vascular endothelial growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "VEGF receptor activity" EXACT [] synonym: "VEGF-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "VEGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005024 name: transforming growth factor beta-activated receptor activity namespace: molecular_function def: "Combining with a transforming growth factor beta (TGFbeta) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate." [GOC:mah, GOC:signaling] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand TGFbeta. For binding to other growth factors, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "TGF-beta receptor activity" EXACT [] synonym: "TGFbeta receptor activity" EXACT [] synonym: "TGFbeta-activated receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "TGFbetaR" EXACT [] synonym: "transforming growth factor beta receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0005025 name: transforming growth factor beta receptor activity, type I namespace: molecular_function def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of TGF-beta signals." [GOC:mah, Reactome:R-HSA-170846] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "type I TGF-beta receptor activity" EXACT [] synonym: "type I TGFbeta receptor activity" EXACT [] synonym: "type I transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity [Term] id: GO:0005026 name: transforming growth factor beta receptor activity, type II namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:R-HSA-170861] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "type II TGF-beta receptor activity" EXACT [] synonym: "type II TGFbeta receptor activity" EXACT [] synonym: "type II transforming growth factor beta receptor activity" EXACT [] xref: reactome:R-HSA-170843 "TGFBR2 phosphorylates TGFBR1" is_a: GO:0005024 ! transforming growth factor beta-activated receptor activity [Term] id: GO:0005027 name: obsolete NGF/TNF (6 C-domain) receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a protein family rather than a molecular function. synonym: "NGF/TNF (6 C-domain) receptor activity" EXACT [] is_obsolete: true consider: GO:0005031 [Term] id: GO:0005028 name: obsolete CD40 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "CD40 receptor activity" EXACT [] is_obsolete: true consider: GO:0042615 [Term] id: GO:0005029 name: obsolete CD27 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. synonym: "CD27 receptor activity" EXACT [] is_obsolete: true consider: GO:0042614 [Term] id: GO:0005030 name: neurotrophin receptor activity namespace: molecular_function def: "Combining with a neurotrophin, any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth, and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling, http://www.mercksource.com/] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0005031 name: tumor necrosis factor-activated receptor activity namespace: molecular_function alt_id: GO:0005032 alt_id: GO:0005033 def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] synonym: "TNF receptor activity" EXACT [] synonym: "TNF receptor activity, type I" NARROW [] synonym: "TNF receptor activity, type II" NARROW [] synonym: "tumor necrosis factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "tumor necrosis factor receptor activity, type I" NARROW [] synonym: "tumor necrosis factor receptor activity, type II" NARROW [] is_a: GO:0005035 ! death receptor activity [Term] id: GO:0005034 name: osmosensor activity namespace: molecular_function def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb] is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0005035 name: death receptor activity namespace: molecular_function def: "Combining with an extracellular messenger (called a death ligand), and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic or necrotic cell death." [GOC:bf, GOC:BHF, GOC:ecd, GOC:mtg_apoptosis, GOC:rl, PMID:10209153] synonym: "apoptosis-activating receptor activity" RELATED [GOC:bf] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0005037 name: obsolete death receptor adaptor protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor adaptor protein activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005038 name: obsolete death receptor interacting protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor interacting protein activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005039 name: obsolete death receptor-associated factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "death receptor-associated factor activity" EXACT [] is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005041 name: low-density lipoprotein particle receptor activity namespace: molecular_function alt_id: GO:0008032 def: "Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis." [GOC:bf, ISBN:0198506732] synonym: "LDL receptor" EXACT [] synonym: "LDLR activity" EXACT [GOC:bf] synonym: "low-density lipoprotein receptor activity" RELATED [] xref: reactome:R-HSA-2404131 "LRPs transport extracellular CR:atREs:HSPG:apoE to cytosol" xref: reactome:R-HSA-2424254 "LDLR transports extracellular CR:atREs to cytosol" xref: Wikipedia:LDL_receptor is_a: GO:0030228 ! lipoprotein particle receptor activity [Term] id: GO:0005042 name: netrin receptor activity namespace: molecular_function def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:dph, GOC:signaling, PMID:15960985] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0005043 name: netrin receptor activity involved in chemorepulsion namespace: molecular_function def: "Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell away from a higher concentration of netrin." [GOC:dph, GOC:signaling] synonym: "netrin receptor activity involved in negative chemotaxis" EXACT [GOC:bf] synonym: "repulsive netrin receptor activity" EXACT [GOC:bf] is_a: GO:0005042 ! netrin receptor activity [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with any modified low-density lipoprotein (LDL) or other polyanionic ligand and delivering the ligand into the cell via endocytosis. Ligands include acetylated and oxidized LDL, Gram-positive and Gram-negative bacteria, apoptotic cells, amyloid-beta fibrils, and advanced glycation end products (AGEs)." [GOC:bf, PMID:11790542, PMID:12379907, PMID:12621157, PMID:20981357] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. For receptors that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children. subset: goslim_chembl synonym: "macrophage receptor activity" NARROW [] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0005045 name: obsolete endoplasmic reticulum receptor activity namespace: molecular_function def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] comment: This term was made obsolete because it represents cellular component and molecular function information. synonym: "endoplasmic reticulum receptor activity" EXACT [] is_obsolete: true consider: GO:0038024 [Term] id: GO:0005046 name: KDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] synonym: "KDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0005047 name: signal recognition particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732] comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. synonym: "docking protein" BROAD [] synonym: "signal recognition particle receptor" NARROW [] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0005048 name: signal sequence binding namespace: molecular_function alt_id: GO:0008249 def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] synonym: "leader sequence binding" NARROW [] synonym: "protein signal sequence binding" NARROW [] synonym: "signal sequence receptor" NARROW [] is_a: GO:0042277 ! peptide binding [Term] id: GO:0005049 name: nuclear export signal receptor activity namespace: molecular_function alt_id: GO:0008262 def: "Combining with a nuclear export signal (NES) on a cargo to be transported, to mediate transport of a the cargo through the nuclear pore, from the nuclear lumen to the cytoplasm. The cargo can be either a RNA or a protein." [GOC:bf, GOC:mah, GOC:pg, GOC:vw, PMID:11743003, PMID:25802992, PMID:28713609, Wikipedia:Nuclear_transport] comment: Changed parents, updated definition see https://github.com/geneontology/go-ontology/issues/14336 synonym: "exportin activity" RELATED [] synonym: "importin-alpha binding" RELATED [] synonym: "importin-alpha export receptor activity" NARROW [GO:0008262] synonym: "NES receptor" EXACT [] is_a: GO:0140142 ! nucleocytoplasmic carrier activity [Term] id: GO:0005050 name: obsolete peroxisome receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "peroxisome receptor" EXACT [] is_obsolete: true consider: GO:0005777 consider: GO:0038023 [Term] id: GO:0005052 name: peroxisome matrix targeting signal-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] synonym: "peroxisomal targeting signal 1 (PTS1) binding" EXACT [PMID:14709540] synonym: "peroxisome targeting signal-1 binding" EXACT [] synonym: "peroxisome targeting signal-1 receptor" NARROW [] synonym: "PEX5" NARROW [] synonym: "PTS1 binding" EXACT [PMID:14709540] synonym: "PTS1 receptor" NARROW [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005053 name: peroxisome matrix targeting signal-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] synonym: "peroxisomal targeting signal 2 (PTS2) binding" EXACT [PMID:14709540] synonym: "peroxisome targeting signal-2 binding" EXACT [] synonym: "peroxisome targeting signal-2 receptor" NARROW [] synonym: "PEX7" NARROW [] synonym: "PTS2 binding" EXACT [PMID:14709540] synonym: "PTS2 receptor" EXACT [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005054 name: obsolete peroxisome integral membrane receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "Pas20p" RELATED [] synonym: "peroxisome integral membrane receptor" EXACT [] is_obsolete: true consider: GO:0038023 [Term] id: GO:0005055 name: laminin receptor activity namespace: molecular_function def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai, PMID:2970671] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. is_a: GO:0098631 ! cell adhesion mediator activity [Term] id: GO:0005056 name: tiggrin receptor activity namespace: molecular_function def: "Combining with the extracellular matrix ligand tiggrin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:9521906] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0005057 name: obsolete signal transducer activity, downstream of receptor namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer, converting the signal into a form where it can ultimately trigger a change in the state or activity of a cell." [GOC:bf] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "intracellular signal transducer activity" EXACT [GOC:bf] synonym: "receptor signaling protein activity" EXACT [] synonym: "receptor signalling protein activity" EXACT [] is_obsolete: true [Term] id: GO:0005061 name: obsolete aryl hydrocarbon receptor nuclear translocator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "aryl hydrocarbon receptor nuclear translocator activity" EXACT [] is_obsolete: true [Term] id: GO:0005065 name: obsolete heterotrimeric G-protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a cellular component and not a molecular function. synonym: "heterotrimeric G-protein" EXACT [] is_obsolete: true replaced_by: GO:0005834 [Term] id: GO:0005066 name: obsolete transmembrane receptor protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein tyrosine kinase signaling protein activity" EXACT [] synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0007169 consider: GO:0035556 [Term] id: GO:0005068 name: transmembrane receptor protein tyrosine kinase adaptor activity namespace: molecular_function alt_id: GO:0005069 def: "The binding activity of a molecule that brings together a transmembrane receptor protein tyrosine kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, PMID:10502414, PMID:20565848] synonym: "transmembrane receptor protein tyrosine kinase adaptor protein activity" EXACT [] synonym: "transmembrane receptor protein tyrosine kinase docking protein activity" RELATED [] is_a: GO:0030159 ! receptor signaling complex adaptor activity is_a: GO:0030971 ! receptor tyrosine kinase binding [Term] id: GO:0005070 name: SH3/SH2 adaptor activity namespace: molecular_function def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] synonym: "SH3/SH2 adaptor protein activity" NARROW [] is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005071 name: obsolete transmembrane receptor protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "transmembrane receptor protein serine/threonine kinase signaling protein activity" EXACT [] synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0007178 consider: GO:0035556 [Term] id: GO:0005072 name: transforming growth factor beta receptor, cytoplasmic mediator activity namespace: molecular_function def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] comment: Note that this term and its children are useful for annotating proteins of the SMAD family. synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0005073 name: obsolete common-partner SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. synonym: "common-partner SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030616 [Term] id: GO:0005074 name: obsolete inhibitory SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. synonym: "inhibitory SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030617 [Term] id: GO:0005075 name: obsolete pathway-specific SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a family of gene products. synonym: "pathway-specific SMAD protein" EXACT [] is_obsolete: true replaced_by: GO:0030618 [Term] id: GO:0005076 name: obsolete receptor signaling protein serine/threonine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein serine/threonine kinase signaling protein activity" EXACT [] synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005077 name: obsolete MAP-kinase anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "MAP-kinase anchor protein activity" EXACT [] synonym: "MAP-kinase anchoring activity" EXACT [] is_obsolete: true consider: GO:0008104 consider: GO:0051019 [Term] id: GO:0005078 name: MAP-kinase scaffold activity namespace: molecular_function def: "The binding activity of a molecule that functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. Binds multiple kinases of the MAPKKK cascade, and also upstream signaling proteins, permitting those molecules to function in a coordinated way. Bringing together multiple enzymes and their substrates enables the signal to be transduced quickly and efficiently." [PMID:12511654, PMID:15213240, PMID:9405336] synonym: "MAP-kinase scaffold protein activity" EXACT [] is_a: GO:0019900 ! kinase binding is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0005079 name: obsolete protein kinase A anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "A-kinase anchor protein activity" EXACT [] synonym: "AKAP activity" EXACT [] synonym: "protein kinase A anchoring activity" EXACT [] is_obsolete: true consider: GO:0008104 consider: GO:0051018 [Term] id: GO:0005080 name: protein kinase C binding namespace: molecular_function alt_id: GO:0072568 alt_id: GO:0072569 alt_id: GO:0097024 def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl] synonym: "PKC alpha binding" EXACT [] synonym: "PKC binding" EXACT [] synonym: "PKC delta binding" EXACT [GOC:BHF, GOC:pr] synonym: "PKC eta binding" EXACT [GOC:BHF, GOC:pr] synonym: "protein kinase C alpha binding" NARROW [] synonym: "protein kinase C delta binding" NARROW [] synonym: "protein kinase C eta binding" NARROW [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0005081 name: obsolete receptor signaling protein serine/threonine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein serine/threonine phosphatase signaling protein activity" EXACT [] synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005082 name: obsolete receptor signaling protein tyrosine phosphatase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein tyrosine phosphatase signaling protein activity" EXACT [] synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0008433 alt_id: GO:0016219 alt_id: GO:0019839 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] comment: Note that guanyl-nucleotide exchange factor (GEF) activity alters binding affinity, but not GTPase catalytic activity directly. Therefore GO:0005085 is under 'regulation of GTPase activity' but is not a 'GTPase regulator', which is reserved for cases where the action of one gene product directly alters the rate of catalysis by another gene product. subset: goslim_chembl subset: goslim_yeast synonym: "GDP-dissociation stimulator activity" EXACT [] synonym: "GDS" EXACT [] synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: reactome:R-HSA-114544 "p115-RhoGEF activation of RHOA" xref: reactome:R-HSA-1168636 "p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP" xref: reactome:R-HSA-1433415 "Activation of RAC1" xref: reactome:R-HSA-156913 "Regeneration of eEF1A:GTP by eEF1B activity" xref: reactome:R-HSA-169904 "C3G stimulates nucleotide exchange on Rap1" xref: reactome:R-HSA-170979 "(Frs2)C3G stimulates nucleotide exchange on Rap1" xref: reactome:R-HSA-187746 "RIT/RIN are activated" xref: reactome:R-HSA-2029445 "Activation of CDC42 by unknown mechanism" xref: reactome:R-HSA-2029451 "Activation of RAC1 by VAV" xref: reactome:R-HSA-2029467 "Activation of RAC1 by CRKII:DOCK180:ELMO" xref: reactome:R-HSA-203977 "SAR1 Activation And Membrane Binding" xref: reactome:R-HSA-205039 "p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor" xref: reactome:R-HSA-2424476 "Activation of RAC1 by VAV2/3" xref: reactome:R-HSA-2485180 "MII catalyses GDP/GTP exchange on Gt" xref: reactome:R-HSA-2730840 "Activation of RAC1 by VAV" xref: reactome:R-HSA-354173 "Activation of Rap1 by cytosolic GEFs" xref: reactome:R-HSA-379044 "Liganded Gs-activating GPCR acts as a GEF for Gs" xref: reactome:R-HSA-379048 "Liganded Gq/11-activating GPCRs act as GEFs for Gq/11" xref: reactome:R-HSA-380073 "Liganded Gi-activating GPCR acts as a GEF for Gi" xref: reactome:R-HSA-389348 "Activation of Rac1 by pVav1" xref: reactome:R-HSA-389350 "Activation of Cdc42 by pVav1" xref: reactome:R-HSA-392195 "Gi activation by P2Y purinoceptor 12" xref: reactome:R-HSA-3928592 "p190RhoGEF exchanges GTP for GDP on RHOA, activating it" xref: reactome:R-HSA-3928612 "KALRN exchanges GTP for GDP on RAC1, activating it" xref: reactome:R-HSA-3928628 "VAV exchanges GTP for GDP on RAC1, activating it" xref: reactome:R-HSA-3928632 "ITSN1 exchanges GTP for GDP on CDC42, activating it" xref: reactome:R-HSA-3928633 "bPIX exchanges GTP for GDP on RAC, activating it" xref: reactome:R-HSA-3928642 "TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: reactome:R-HSA-3928651 "NGEF exchanges GTP for GDP on RHOA" xref: reactome:R-HSA-392870 "Gs activation by prostacyclin receptor" xref: reactome:R-HSA-3965444 "WNT:FZD complex promotes G-protein nucleotide exchange" xref: reactome:R-HSA-399995 "Muscarinic Acetylcholine Receptor M3 activates Gq" xref: reactome:R-HSA-4093336 "p-TIAM1 exchanges GTP for GDP on RAC1, activating it" xref: reactome:R-HSA-416530 "GPR40:fatty acid activates Gq" xref: reactome:R-HSA-418579 "Gq activation by P2Y purinoceptor 1" xref: reactome:R-HSA-420883 "Opsins act as GEFs for G alpha-t" xref: reactome:R-HSA-428750 "Gq activation by TP receptor" xref: reactome:R-HSA-428917 "G13 activation by TP receptor" xref: reactome:R-HSA-442273 "VAV1 is a GEF for Rho/Rac family kinases" xref: reactome:R-HSA-442291 "VAV2 is a GEF for Rho/Rac family kinases" xref: reactome:R-HSA-442314 "VAV3 is a GEF for Rho/Rac family kinases" xref: reactome:R-HSA-445064 "Activation of Rac1 by VAV2" xref: reactome:R-HSA-5218829 "VEGF induces CDC42 activation by unknown mechanism" xref: reactome:R-HSA-5218839 "DOCK180:ELMO exchanges GTP for GDP, activating RAC1" xref: reactome:R-HSA-5218850 "VAV exchanges GTP for GDP on RAC1, activating it" xref: reactome:R-HSA-5694409 "Nucleotide exchange on RAB1" xref: reactome:R-HSA-6807868 "GBF1 stimulates ARF nucleotide exchange" xref: reactome:R-HSA-6811429 "RIC1:RGP1 stimulates nucleotide RAB6 nucleotide exchange" xref: reactome:R-HSA-749453 "Liganded Gz-activating GPCR acts as a GEF for Gz" xref: reactome:R-HSA-751029 "Liganded G12/13-activating GPCR acts as a GEF for G12/13" xref: reactome:R-HSA-825631 "Glucagon:GCGR mediates GTP-GDP exchange" xref: reactome:R-HSA-8848618 "Activation of RAC1 by the PXN:CRK complex" xref: reactome:R-HSA-8850041 "RAB3GAP1:RAB3GAP2 promotes nucleotide exchange on RAB18" xref: reactome:R-HSA-8851827 "RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1" xref: reactome:R-HSA-8851877 "RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET" xref: reactome:R-HSA-8851899 "RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET" xref: reactome:R-HSA-8875568 "RAPGEF1 activates RAP1" xref: reactome:R-HSA-8875591 "DOCK7 activates RAC1" xref: reactome:R-HSA-8964604 "CDC42 in GNB/GNG:PAK1:ARHGEF6:CDC42 is activated" xref: reactome:R-HSA-8982637 "Opsins binds G alpha-t" xref: reactome:R-HSA-8982640 "G-alpha(t):G-beta-gamma:Opsins complex dissociates to active G-alpha(t)" xref: reactome:R-HSA-939265 "Activation of Rap1 by membrane-associated GEFs" is_a: GO:0051020 ! GTPase binding is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0005086 name: ARF guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: reactome:R-HSA-350769 "trans-Golgi Network Coat Activation" xref: reactome:R-HSA-5623508 "GBF1 stimulates nucleotide exchange on ARF4" xref: reactome:R-HSA-6811414 "GBF1 stimulates nucleotide exchange on ARF" xref: reactome:R-HSA-6811418 "ARFGAPs stimulate ARF GTPase activity at the Golgi membrane" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005087 name: Ran guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: reactome:R-HSA-180687 "Conversion of Ran-GDP to Ran-GTP" xref: Wikipedia:RCC1 is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0008536 ! Ran GTPase binding [Term] id: GO:0005088 name: Ras guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: reactome:R-HSA-109807 "GRB2:SOS:p-Y427-SHC1 mediated nucleotide exchange of RAS" xref: reactome:R-HSA-109817 "GRB2:SOS1:p-Y-IRS1,p-Y-IRS2 mediated nucleotide exchange of RAS" xref: reactome:R-HSA-1225951 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with ligand-responsive p-6Y-EGFR mutants)" xref: reactome:R-HSA-1225957 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and ligand-responsive p-6Y-EGFR mutants)" xref: reactome:R-HSA-1250383 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4" xref: reactome:R-HSA-1250463 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-SHC1:Phosphorylated ERBB2 heterodimers" xref: reactome:R-HSA-1250498 "RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and phosphorylated EGFR:ERBB2 heterodimers." xref: reactome:R-HSA-1306972 "RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers" xref: reactome:R-HSA-1433471 "Activation of RAS by p-KIT bound SOS1" xref: reactome:R-HSA-177938 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1)" xref: reactome:R-HSA-177945 "SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1)" xref: reactome:R-HSA-186834 "Sos-mediated nucleotide exchange of Ras (PDGF receptor:Grb2:Sos)" xref: reactome:R-HSA-210977 "Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos)" xref: reactome:R-HSA-2179407 "SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated)" xref: reactome:R-HSA-2424477 "SOS mediated nucleotide exchange of RAS (SHC)" xref: reactome:R-HSA-392054 "NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras" xref: reactome:R-HSA-442732 "NMDA-activated RASGRF1 activates RAS" xref: reactome:R-HSA-5637806 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with p-EGFRvIII)" xref: reactome:R-HSA-5637808 "SOS-mediated nucleotide exchange of RAS (mediated by GRB2:SOS1 in complex with phosphorylated SHC1 and p-EGFRvIII)" xref: reactome:R-HSA-5654392 "Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654402 "Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654413 "Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654426 "Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654600 "Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654618 "Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654647 "Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5654663 "Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5655241 "Activated FGFR2 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5655277 "Activated FGFR3 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5655326 "Activated FGFR1 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5655347 "Activated FGFR4 mutants:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-5672965 "RAS GEFs promote RAS nucleotide exchange" xref: reactome:R-HSA-5686071 "GRB2-1:SOS1:p-Y-SHC mediated nucleotide exchange of RAS" xref: reactome:R-HSA-5686318 "GRB2-1:SOS1:p-3Y-SHC1 mediated nucleotide exchange of RAS" xref: reactome:R-HSA-8853307 "FGFR3 fusions:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange" xref: reactome:R-HSA-9026891 "NTRK2 activates RAS signaling through SHC1" xref: reactome:R-HSA-9029158 "EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-CRKL:RAPGEF1:GRB2-1:SOS1,phospho-VAV1 mediates exchange of GTP for GDP bound to RAS" xref: reactome:R-HSA-9032067 "NTRK2 activates RAS signaling through FRS2" is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0005089 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] subset: goslim_chembl synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: reactome:R-HSA-194518 "RhoA is activated by nucleotide exchange and inhibits axonal growth" xref: reactome:R-HSA-194913 "GEFs activate Rho GTPase:GDP" xref: reactome:R-HSA-416588 "Activation of Rho by LARG and PDZ-RhoGEF" xref: reactome:R-HSA-418850 "Activation of Cdc42" xref: reactome:R-HSA-418856 "Activation of Rac1" xref: reactome:R-HSA-419166 "GEFs activate RhoA,B,C" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0005090 name: Sar guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005091 name: guanyl-nucleotide exchange factor adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other proteins, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07, GOC:vw] is_a: GO:0030674 ! protein binding, bridging is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005092 name: GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] synonym: "GDI" EXACT [] is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005093 name: Rab GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005094 name: Rho GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005095 name: GTPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] synonym: "GIP" BROAD [] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005096 name: GTPase activator activity namespace: molecular_function alt_id: GO:0005097 alt_id: GO:0005098 alt_id: GO:0005099 alt_id: GO:0005100 alt_id: GO:0005101 alt_id: GO:0008060 alt_id: GO:0017123 alt_id: GO:0030675 alt_id: GO:0046582 def: "Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. synonym: "ARF GAP activity" NARROW [GOC:pg] synonym: "ARF GTPase activator activity" NARROW [] synonym: "GAP activity" EXACT [] synonym: "Rab GAP activity" NARROW [GOC:pg] synonym: "Rab GTPase activator activity" NARROW [] synonym: "Rac GAP activity" NARROW [GOC:pg] synonym: "Rac GTPase activator activity" NARROW [] synonym: "Ral GAP activity" NARROW [GOC:pg] synonym: "Ral GTPase activator activity" NARROW [] synonym: "Ran GAP activity" NARROW [GOC:pg] synonym: "Ran GTPase activator activity" NARROW [] synonym: "RanGAP" NARROW [] synonym: "Rap GAP activity" NARROW [GOC:pg] synonym: "Rap GTPase activator activity" NARROW [] synonym: "Ras GAP activity" NARROW [GOC:pg] synonym: "Ras GTPase activator activity" NARROW [] synonym: "Rho GAP activity" NARROW [GOC:pg] synonym: "Rho GTPase activator activity" NARROW [] synonym: "Sar GAP activity" NARROW [GOC:pg] synonym: "Sar GTPase activator activity" NARROW [] xref: reactome:R-HSA-194922 "GAPs inactivate Rho GTPase:GTP by hydrolysis" xref: reactome:R-HSA-392513 "Rap1 signal termination by Rap1GAPs" xref: reactome:R-HSA-399935 "Inactivation of R-Ras by Sema3A-Plexin-A GAP activity" xref: reactome:R-HSA-4093339 "p120-RasGAP activates GTP hydrolysis on RAS, inactivating it" xref: reactome:R-HSA-416546 "Inactivation of R-Ras by Sema4D-Plexin-B1 GAP activity" xref: reactome:R-HSA-416559 "Inactivation of Rho-GTP by p190RhoGAP" xref: reactome:R-HSA-428522 "Inactivation of RAC1" xref: reactome:R-HSA-428533 "Inactivation of CDC42" xref: reactome:R-HSA-5638007 "RP2 activates the GTPase activity of ARL3" xref: reactome:R-HSA-8985594 "MYO9B inactivates RHOA" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005102 name: signaling receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732] comment: Where appropriate, also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_plant synonym: "receptor binding" BROAD [] synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005104 name: fibroblast growth factor receptor binding namespace: molecular_function alt_id: GO:0001521 alt_id: GO:0005162 def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. synonym: "FGF receptor binding" EXACT [] synonym: "FGFR binding" EXACT [] synonym: "FGFR ligand" NARROW [] synonym: "fibroblast growth factor" BROAD [] synonym: "fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005105 name: type 1 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). synonym: "breathless binding" NARROW [] synonym: "breathless ligand" NARROW [] synonym: "FGFR1 binding" BROAD [] synonym: "FGFR1 ligand" NARROW [] synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005106 name: obsolete ephrin namespace: molecular_function def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ephrin" EXACT [] is_obsolete: true consider: GO:0046875 [Term] id: GO:0005107 name: obsolete GPI-linked ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "GPI-linked ephrin" EXACT [] is_obsolete: true consider: GO:0046658 consider: GO:0046875 [Term] id: GO:0005108 name: obsolete transmembrane ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "transmembrane ephrin" EXACT [] is_obsolete: true consider: GO:0005887 consider: GO:0046875 [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function alt_id: GO:0005110 def: "Interacting selectively and non-covalently with a frizzled (fz) receptor." [GOC:ceb, PR:000001315] subset: goslim_chembl synonym: "frizzled ligand" NARROW [] synonym: "frizzled-2 binding" NARROW [] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] synonym: "fz2 binding" NARROW [] synonym: "fz2 ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0005111 name: type 2 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). synonym: "FGFR2 binding" EXACT [] synonym: "FGFR2 ligand" NARROW [] synonym: "heartless binding" EXACT [] synonym: "heartless ligand" NARROW [] synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005112 name: Notch binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] synonym: "N binding" EXACT [] synonym: "N ligand" NARROW [] synonym: "Notch ligand" NARROW [] synonym: "Notch receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005113 name: patched binding namespace: molecular_function def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] synonym: "patched ligand" NARROW [] synonym: "ptc binding" EXACT [] synonym: "ptc ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005114 name: type II transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] synonym: "punt binding" NARROW [] synonym: "punt ligand" NARROW [] synonym: "TGF-beta type II binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor type II binding" EXACT [] synonym: "type II TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0005115 name: receptor tyrosine kinase-like orphan receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb, GOC:vw] synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] synonym: "Ror binding" BROAD [] synonym: "Ror ligand" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005117 name: wishful thinking binding namespace: molecular_function def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] synonym: "SE20 receptor binding" NARROW [] synonym: "wishful thinking ligand" NARROW [] synonym: "Wit binding" EXACT [] synonym: "Wit ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005118 name: sevenless binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:3151175] synonym: "sev binding" EXACT [] synonym: "sev ligand" NARROW [] synonym: "sevenless ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005119 name: smoothened binding namespace: molecular_function def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] synonym: "smo binding" EXACT [] synonym: "smo ligand" NARROW [] synonym: "smoothened ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0005121 name: Toll binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] synonym: "Tl binding" EXACT [] synonym: "Toll ligand" NARROW [] synonym: "Toll receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005122 name: torso binding namespace: molecular_function def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [GOC:ceb, PMID:2927509] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] subset: goslim_chembl synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005124 name: scavenger receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] synonym: "scavenger receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cytokine receptor." [GOC:mah, GOC:vw] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005127 name: ciliary neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai] synonym: "ciliary neurotrophic factor" NARROW [] synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005128 name: erythropoietin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai] synonym: "erythropoietin" NARROW [] synonym: "erythropoietin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005129 name: granulocyte macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "GM-CSF receptor binding" EXACT [GOC:vk] synonym: "GM-CSF receptor ligand" NARROW [] synonym: "GMC-SF receptor ligand" NARROW [] synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor" NARROW [] synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005130 name: granulocyte colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai] synonym: "G-CSF receptor ligand" EXACT [] synonym: "GC-SF receptor ligand" EXACT [] synonym: "granulocyte colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte colony-stimulating factor" NARROW [] synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005131 name: growth hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai] synonym: "growth hormone" NARROW [] synonym: "growth hormone receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0005132 name: type I interferon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an interferon-type I receptor, a heterodimeric complex composed of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2)." [GOC:ai, GOC:signaling, PMID:17502368] synonym: "IFNAR binding" RELATED [PMID:17502368] synonym: "IFNAR1 binding" NARROW [PR:000008922] synonym: "IFNAR2 binding" NARROW [PR:000008923] synonym: "interferon-alpha/beta" NARROW [] synonym: "interferon-alpha/beta receptor binding" EXACT [PR:000008922, PR:000008923] synonym: "interferon-alpha/beta receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005133 name: interferon-gamma receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai] synonym: "interferon-gamma" NARROW [] synonym: "interferon-gamma receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005134 name: interleukin-2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai] synonym: "IL-2" NARROW [] synonym: "interleukin-2 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005135 name: interleukin-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai] synonym: "IL-3" NARROW [] synonym: "interleukin-3 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005136 name: interleukin-4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai] synonym: "IL-4" NARROW [] synonym: "interleukin-4 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai] subset: goslim_chembl synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005139 name: interleukin-7 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai] synonym: "IL-7" NARROW [] synonym: "interleukin-7 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005140 name: interleukin-9 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai] synonym: "IL-9" NARROW [] synonym: "interleukin-9 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005141 name: interleukin-10 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai] synonym: "IL-10" NARROW [] synonym: "interleukin-10 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005142 name: interleukin-11 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai] synonym: "IL-11" NARROW [] synonym: "interleukin-11 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005143 name: interleukin-12 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai] synonym: "IL-12" NARROW [] synonym: "interleukin-12 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005144 name: interleukin-13 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai] synonym: "IL-13" NARROW [] synonym: "interleukin-13 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005145 name: interleukin-14 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai] synonym: "IL-14" NARROW [] synonym: "interleukin-14 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005146 name: leukemia inhibitory factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai] synonym: "leukemia inhibitory factor" NARROW [] synonym: "leukemia inhibitory factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005147 name: oncostatin-M receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai] synonym: "oncostatin-M" NARROW [] synonym: "oncostatin-M receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005148 name: prolactin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai] synonym: "prolactin" NARROW [] synonym: "prolactin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005149 name: interleukin-1 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators] synonym: "IL-1" NARROW [] synonym: "interleukin-1 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005150 name: interleukin-1, type I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type I" NARROW [] synonym: "interleukin-1, type I receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005151 name: interleukin-1, type II receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type II" NARROW [] synonym: "interleukin-1, type II receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005152 name: interleukin-1 receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] synonym: "IL-1ra" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0019966 ! interleukin-1 binding is_a: GO:0048019 ! receptor antagonist activity [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators] subset: goslim_chembl synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] subset: goslim_chembl synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005155 name: obsolete epidermal growth factor receptor activating ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor activating ligand activity" EXACT [] synonym: "EGFR activating ligand activity" EXACT [] synonym: "epidermal growth factor receptor activating ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0030297 consider: GO:0045741 [Term] id: GO:0005156 name: obsolete epidermal growth factor receptor inhibiting ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor inhibiting ligand activity" EXACT [] synonym: "EGFR inhibiting ligand activity" EXACT [] synonym: "epidermal growth factor receptor inhibiting ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0007175 consider: GO:0030293 [Term] id: GO:0005157 name: macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "M-CSF receptor binding" EXACT [GOC:vk] synonym: "macrophage colony stimulating factor receptor binding" EXACT [] synonym: "macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005158 name: insulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] synonym: "insulin receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005159 name: insulin-like growth factor receptor binding namespace: molecular_function alt_id: GO:0005067 def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl] synonym: "IGF receptor binding" EXACT [] synonym: "insulin-like growth factor" NARROW [] synonym: "insulin-like growth factor receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005160 name: transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai] synonym: "activin" RELATED [] synonym: "inhibin" RELATED [] synonym: "TGF-beta receptor binding" EXACT [] synonym: "TGFbeta receptor binding" EXACT [] synonym: "transforming growth factor beta" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] xref: reactome:R-HSA-170861 "Dimeric TGF-beta-1 binds to the receptor" xref: reactome:R-HSA-201457 "BMP2 binds to the receptor complex" is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005161 name: platelet-derived growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai] synonym: "PDGF" NARROW [] synonym: "PDGF receptor binding" EXACT [] synonym: "PDGFR binding" EXACT [] synonym: "platelet-derived growth factor" NARROW [] synonym: "platelet-derived growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005163 name: nerve growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015] synonym: "nerve growth factor receptor ligand" NARROW [] synonym: "neurotrophin" NARROW [] synonym: "NGF receptor binding" EXACT [] is_a: GO:0005123 ! death receptor binding is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai] subset: goslim_chembl synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005165 name: neurotrophin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai] synonym: "neurotrophin" NARROW [] synonym: "neurotrophin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005166 name: neurotrophin p75 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai] synonym: "neurotrophin p75 receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005167 name: neurotrophin TRK receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai] synonym: "neurotrophin TRK receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005168 name: neurotrophin TRKA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai] synonym: "neurotrophin TRKA receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005169 name: neurotrophin TRKB receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai] synonym: "neurotrophin TRKB receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005170 name: neurotrophin TRKC receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai] synonym: "neurotrophin TRKC receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005171 name: hepatocyte growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai] synonym: "hepatocyte growth factor" NARROW [] synonym: "hepatocyte growth factor receptor ligand" NARROW [] synonym: "HGF receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005174 name: CD40 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005175 name: CD27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005176 name: ErbB-2 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] synonym: "ErbB-2 class receptor ligand" NARROW [] synonym: "HER2 receptor binding" EXACT [] synonym: "HER2 receptor ligand" NARROW [] synonym: "Neu receptor binding" EXACT [] synonym: "Neu receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005177 name: obsolete neuroligin namespace: molecular_function def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] synonym: "neuroligin" EXACT [] is_obsolete: true consider: GO:0042043 [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb] subset: goslim_chembl synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0044877 ! protein-containing complex binding is_a: GO:0050839 ! cell adhesion molecule binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0005180 name: obsolete peptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "peptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005181 name: obsolete glycopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "glycopeptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005182 name: obsolete lipopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. synonym: "lipopeptide hormone" EXACT [] is_obsolete: true consider: GO:0005179 [Term] id: GO:0005183 name: gonadotropin hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the hypothalamus in response to neural and/or chemical stimuli. In at least mammals, upon receptor binding, GnRH causes the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) by the anterior pituitary." [ISBN:0198506732, PMID:11026571, Wikipedia:Gonadotropin-releasing_hormone] synonym: "GnRH activity" EXACT [ISBN:0198506732] synonym: "gonadotrophin hormone-releasing hormone activity" EXACT [GOC:dph] synonym: "LH/FSH-RF" EXACT [ISBN:0198506732] synonym: "LHRH activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] subset: goslim_chembl synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005185 name: neurohypophyseal hormone activity namespace: molecular_function def: "The action characteristic of a neurohypophyseal hormone, any of a family of structurally and functionally related nonapeptides that are synthesized as part of a larger precursor molecule comprising a signal peptide, the nonapeptide hormone, and a neurophysin." [GOC:mah, PMID:19243634] synonym: "neurohypophysial hormone activity" EXACT [GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0005186 name: pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0005187 name: obsolete storage protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. synonym: "storage protein" EXACT [] is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0005188 name: obsolete larval serum protein (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "arylphorin" NARROW [] synonym: "larval serum protein (sensu Insecta)" EXACT [] is_obsolete: true [Term] id: GO:0005189 name: obsolete milk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "milk protein" EXACT [] is_obsolete: true [Term] id: GO:0005190 name: obsolete seminal fluid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "seminal fluid protein" EXACT [] is_obsolete: true [Term] id: GO:0005191 name: obsolete acidic epididymal glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. synonym: "acidic epididymal glycoprotein" EXACT [] is_obsolete: true [Term] id: GO:0005192 name: obsolete urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "urinary protein" EXACT [] is_obsolete: true [Term] id: GO:0005193 name: obsolete major urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "major urinary protein" EXACT [] is_obsolete: true [Term] id: GO:0005194 name: obsolete cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. synonym: "cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 consider: GO:0098631 [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or its assembly within or outside a cell." [GOC:mah, GOC:vw] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast is_a: GO:0003674 ! molecular_function [Term] id: GO:0005199 name: structural constituent of cell wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005200 name: structural constituent of cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005201 name: extracellular matrix structural constituent namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] comment: Extracellular matrix glycoproteins may be annotated to this term. PMID:24443019 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] synonym: "extracellular matrix glycoprotein" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005202 name: obsolete collagen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "collagen" EXACT [] is_obsolete: true consider: GO:0005581 [Term] id: GO:0005203 name: obsolete proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005204 name: obsolete chondroitin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulfate proteoglycan" EXACT [] synonym: "chondroitin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005205 name: obsolete chondroitin sulfate/dermatan sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulfate/dermatan sulfate proteoglycan" EXACT [] synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005206 name: obsolete heparin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "heparin sulfate proteoglycan" EXACT [] synonym: "heparin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005207 name: obsolete extracellular matrix glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes localization and modification rather than activity. synonym: "extracellular matrix glycoprotein" EXACT [] is_obsolete: true consider: GO:0005201 [Term] id: GO:0005208 name: obsolete amyloid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "amyloid protein" EXACT [] is_obsolete: true [Term] id: GO:0005209 name: obsolete plasma protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "plasma protein" EXACT [] is_obsolete: true [Term] id: GO:0005211 name: obsolete plasma glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. synonym: "plasma glycoprotein" EXACT [] is_obsolete: true [Term] id: GO:0005212 name: structural constituent of eye lens namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005213 name: structural constituent of chorion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] synonym: "structural protein of chorion" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005214 name: structural constituent of chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, or between cells." [GOC:ai, GOC:dgf] comment: Some transporters, such as certain members of the SLC family, are referred to as 'carriers'; however GO uses carrier with a different meaning: a carrier binds to and transports the substance (see GO:0140104 molecular carrier activity), whereas a transporter forms some pore that allows the passing of molecules. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "carrier" RELATED [] xref: reactome:R-HSA-168313 "Virion-associated M2 protein mediated ion infusion" xref: reactome:R-HSA-178215 "SMAD7:SMURF1 complex is exported to the cytosol" is_a: GO:0003674 ! molecular_function [Term] id: GO:0005216 name: ion channel activity namespace: molecular_function def: "Enables the facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. May be either selective (it enables passage of a specific ion only) or non-selective (it enables passage of two or more ions of same charge but different size)." [GOC:cy, GOC:mtg_transport, GOC:pr, ISBN:0815340729] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015267 ! channel activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0005217 name: intracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005219 name: ryanodine-sensitive calcium-release channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] synonym: "caffeine-sensitive calcium-release channel" RELATED [] synonym: "ryanodine receptor" NARROW [] xref: reactome:R-HSA-2855020 "RYR tetramers transport Ca2+ from sarcoplasmic reticulum lumen to cytosol" is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005220 name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: molecular_function alt_id: GO:0008095 def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate (IP3) has been bound by the channel complex or one of its constituent parts." [GOC:mah, GOC:signaling, PMID:8660280, Wikipedia:Inositol_trisphosphate_receptor] synonym: "inositol-1,4,5-trisphosphate receptor activity" EXACT [] synonym: "InsP3 receptor" EXACT [GOC:bf] synonym: "IP3 receptor activity" EXACT [] is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005221 name: intracellular cyclic nucleotide activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] xref: reactome:R-HSA-2514867 "cGMP:CNG transports Na+ and Ca2+ into the rod outer segment" is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0005222 name: intracellular cAMP-activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "HCN channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "hyperpolarization-activated cyclic nucleotide-gated channel activity" BROAD [GOC:BHF, GOC:mtg_cardiac_conduct_nov11] synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] synonym: "intracellular cAMP activated cation channel activity" EXACT [] synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005223 name: intracellular cGMP-activated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "intracellular cGMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005225 name: volume-sensitive anion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb] synonym: "volume-regulated channel" BROAD [] xref: reactome:R-HSA-8941543 "VRAC heteromer transports I-, Cl- from cytosol to extracellular region" is_a: GO:0005253 ! anion channel activity [Term] id: GO:0005227 name: calcium activated cation channel activity namespace: molecular_function def: "Enables the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] is_a: GO:0005261 ! cation channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005228 name: intracellular sodium activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005229 name: intracellular calcium activated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: reactome:R-HSA-2684901 "ANOs transport cytosolic Cl- to extracellular region" xref: reactome:R-HSA-2744242 "TTYH2/3 transport cytosolic Cl- to extracellular region" xref: reactome:R-HSA-2744361 "BESTs transport cytosolic Cl- to extracellular region" is_a: GO:0022839 ! ion gated channel activity is_a: GO:0061778 ! intracellular chloride channel activity [Term] id: GO:0005230 name: extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005231 name: excitatory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts, where channel opening contributes to an increase in membrane potential." [GOC:mah, ISBN:0323037070] xref: reactome:R-HSA-399711 "Activation of Ca impermeable AMPA receptors" xref: reactome:R-HSA-399712 "Activation of Ca permeable AMPA receptors" xref: reactome:R-HSA-420980 "Activation of Ca permeable AMPA receptors" xref: reactome:R-HSA-432164 "Ca2+ influx into the post-synaptic cell" xref: reactome:R-HSA-438037 "Membrane depolarization upon activation of Ca impermeable AMPA receptors" is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005234 name: extracellularly glutamate-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. synonym: "extracellular-glutamate-gated ion channel activity" EXACT [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0005237 name: inhibitory extracellular ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific extracellular inhibitory ligand has been bound by the channel complex or one of its constituent parts. Inhibitory ligands, such as GABA or glycine, open chloride-selective channels." [GOC:mah, ISBN:0323037070] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005240 name: obsolete glycine receptor-associated protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a molecular function. synonym: "glycine receptor-associated protein" EXACT [] is_obsolete: true consider: GO:0005515 [Term] id: GO:0005241 name: obsolete inward rectifier channel namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "inward rectifier channel" EXACT [] is_obsolete: true consider: GO:0005242 [Term] id: GO:0005242 name: inward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] synonym: "Kir channel activity" EXACT [GOC:cb] xref: reactome:R-HSA-1296045 "Activation of Potassium transport channels" xref: reactome:R-HSA-1296046 "KCNJs transport K+ from the extracellular region to cytosol" xref: reactome:R-HSA-1369017 "Activation of ATP sensitive Potassium channels in muscle cells" xref: reactome:R-HSA-5678261 "KCNJ11:ABCC9 transports K+ from extracellular region to cytosol" is_a: GO:0005249 ! voltage-gated potassium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0005243 name: gap junction channel activity namespace: molecular_function alt_id: GO:0015285 alt_id: GO:0015286 def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] synonym: "connexin" RELATED [] synonym: "innexin" NARROW [] synonym: "innexin channel activity" EXACT [] synonym: "intercellular channel" BROAD [] xref: reactome:R-HSA-190681 "Connexin oligomerization in endoplasmic reticulum membrane" xref: reactome:R-HSA-375330 "Connexin 45/Connexin 36 mediated neuronal gap junction communication" xref: reactome:R-HSA-375339 "Pannexin 1/Pannexin2 mediated neuronal gap junction communication" xref: reactome:R-HSA-375340 "Connexin 62 mediated neuronal gap junction communication" xref: reactome:R-HSA-375342 "Connexin 36 mediated neuronal gap junction communication" is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0005244 name: voltage-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] is_a: GO:0022832 ! voltage-gated channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005245 name: voltage-gated calcium channel activity namespace: molecular_function alt_id: GO:0010173 alt_id: GO:0015270 def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "dihydropyridine-sensitive calcium channel activity" NARROW [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: reactome:R-HSA-265645 "Calcium Influx through Voltage-gated Calcium Channels" xref: reactome:R-HSA-5577213 "LTCC heteropentamer (open) transports Ca2+ from extracellular region to cytosol" is_a: GO:0005262 ! calcium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005246 name: calcium channel regulator activity namespace: molecular_function def: "Modulates the activity of a calcium channel." [GOC:mah] is_a: GO:0099106 ! ion channel regulator activity [Term] id: GO:0005247 name: voltage-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated chloride channel activity" EXACT [] synonym: "voltage-dependent chloride channel activity" EXACT [] xref: reactome:R-HSA-2744228 "CLCN1/2/KA/KB transport cytosolic Cl- to extracellular region" is_a: GO:0005254 ! chloride channel activity is_a: GO:0008308 ! voltage-gated anion channel activity [Term] id: GO:0005248 name: voltage-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] xref: reactome:R-HSA-5576895 "SCNAs:SNCBs transport Na+ from extracellular region to cytosol" is_a: GO:0005272 ! sodium channel activity [Term] id: GO:0005249 name: voltage-gated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] xref: reactome:R-HSA-1296127 "Activation of voltage gated Potassium channels" is_a: GO:0005267 ! potassium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005250 name: A-type (transient outward) potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] xref: reactome:R-HSA-5577234 "KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region" is_a: GO:0015271 ! outward rectifier potassium channel activity [Term] id: GO:0005251 name: delayed rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and inactivation is slow." [GOC:mah, PMID:11343411, PMID:2462513] xref: reactome:R-HSA-5577050 "AKAP9:KCNQ1 tetramer:KCNE dimer transports K+ from cytosol to extracellular region" xref: reactome:R-HSA-5577237 "KCNH2:KCNE transport K+ from cytosol to extracellular region" is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005252 name: open rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005253 name: anion channel activity namespace: molecular_function def: "Enables the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "non-selective anion channel activity" NARROW [] xref: reactome:R-HSA-432034 "Aquaporin-6 passively transports anions into vesicles" xref: reactome:R-HSA-432036 "Aquaporin-6 passively transports anions out of vesicles" is_a: GO:0005216 ! ion channel activity is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0005254 name: chloride channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: reactome:R-HSA-2744349 "TTYH1 transports cytosolic Cl- to extracellular region" xref: reactome:R-HSA-427570 "Group 3 - Selective Cl- transport" xref: reactome:R-HSA-975340 "GABR heteropentamers:GABA transport Cl- from extracellular region to cytosol" xref: reactome:R-HSA-975449 "GABRR pentamer:GABA transports extracellular Cl- to cytosol" is_a: GO:0005253 ! anion channel activity is_a: GO:0015108 ! chloride transmembrane transporter activity [Term] id: GO:0005260 name: intracellularly ATP-gated chloride channel activity namespace: molecular_function alt_id: GO:0005224 def: "Enables passage of a chloride ion through a transmembrane channel that opens when ATP is bound by the channel complex or one of its constituent parts on the intracellular side of the plasma membrane." [EC:3.6.3.49, PMID:24727426, PMID:9922375, Wiki:Cystic_fibrosis_transmembrane_conductance_regulator] comment: https://github.com/geneontology/go-ontology/issues/14402 synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49] synonym: "ATP-binding and phosphorylation-dependent chloride channel activity" EXACT [] synonym: "channel-conductance-controlling ATPase activity" EXACT [] synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49] xref: EC:3.6.3.49 xref: MetaCyc:3.6.3.49-RXN is_a: GO:0005254 ! chloride channel activity is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0099095 ! ligand-gated anion channel activity is_a: GO:0099142 ! intracellularly ATP-gated ion channel activity [Term] id: GO:0005261 name: cation channel activity namespace: molecular_function alt_id: GO:0015281 alt_id: GO:0015338 def: "Enables the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "cation diffusion facilitator activity" EXACT [] synonym: "non-selective cation channel activity" NARROW [] xref: reactome:R-HSA-1168376 "STIM1 oligomerizes" xref: reactome:R-HSA-1296043 "Activation of HCN channels" xref: reactome:R-HSA-169683 "IP3R:I(1,4,5)P3 tetramer transports Ca2+ from ER lumen to cytosol" xref: reactome:R-HSA-2089943 "TRPC1 translocates calcium from the extracellular region to the cytosol" xref: reactome:R-HSA-426223 "Cation influx mediated by TRPC3/6/7" xref: reactome:R-HSA-4420052 "Decreasing cGMP concentration promotes intracellular Ca2+ release in response to WNT" is_a: GO:0005216 ! ion channel activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0005262 name: calcium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: reactome:R-HSA-139854 "IP3R tetramer:I(1,4,5)P3:4xCa2+ transports Ca2+ from platelet dense tubular system to cytosol" xref: reactome:R-HSA-139855 "P2X1-mediated entry of Ca++ from plasma" xref: reactome:R-HSA-210420 "Ca2+ influx through voltage gated Ca2+ channels" xref: reactome:R-HSA-3295579 "TRPs transport extracellular Ca2+ to cytosol" xref: reactome:R-HSA-5263618 "CACFD1 dimer transports Ca2+ from extracellular region to cytosol" xref: reactome:R-HSA-8949145 "VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space" xref: reactome:R-HSA-8949178 "MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix" is_a: GO:0005261 ! cation channel activity is_a: GO:0015085 ! calcium ion transmembrane transporter activity [Term] id: GO:0005267 name: potassium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: reactome:R-HSA-1296024 "Activation of ATP sensitive Potassium channels in neuroendocrine cells" xref: reactome:R-HSA-1296035 "Activation of Ca2+ activated Potassium channels with Intermeidtance conductance" xref: reactome:R-HSA-1296037 "Activation of Ca2+ activated Potassium channels with large conductance" xref: reactome:R-HSA-1296039 "Activation of Ca2+ activated Potassium channels with small conductance" xref: reactome:R-HSA-1296348 "Activation of TWIK-related K+ channel (TREK)" xref: reactome:R-HSA-1299297 "Activation of THIK" xref: reactome:R-HSA-1299304 "Activation of tandem pore domain in a weak inwardly rectifying K+ channels" xref: reactome:R-HSA-1299318 "Activation of TASK" xref: reactome:R-HSA-1299338 "Activation of TRESK" xref: reactome:R-HSA-1299359 "Activation of TALK" xref: reactome:R-HSA-2534365 "Slo3 Potassium Transport" xref: reactome:R-HSA-5578910 "KCNK dimers transport K+ from cytosol to extracellular region" is_a: GO:0005261 ! cation channel activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity [Term] id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:BHF, GOC:mtg_transport, GOC:pr, ISBN:0815340729] xref: reactome:R-HSA-2730664 "UNC79:UNC80:NALCN transports cytosolic Na+ to extracellular region" xref: reactome:R-HSA-3295580 "TRPM4,5 transport extracellular Na+ to cytosol" is_a: GO:0005261 ! cation channel activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0005274 name: allantoin:proton symporter activity namespace: molecular_function alt_id: GO:0015206 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] synonym: "allantoin permease activity" RELATED [] synonym: "allantoin uptake transmembrane transporter activity" NARROW [] synonym: "allantoin/allantoate transporter" BROAD [] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005279 def: "Enables the transfer of amines, including polyamines, from one side of a membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0005276 name: obsolete vesicular amino acid:proton antiporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a vesicle membrane to the other according to the reaction: H+(in) + amino acid(out) = H+(out) + amino acid(in)." [GOC:mah, Reactome:428625] comment: The reason for obsoletion is that the cellular component does not belong is the MF according to the documentation: http://wiki.geneontology.org/index.php/Transporter_terms_standard_definitions synonym: "hydrogen:vesicular amine antiporter activity" EXACT [GOC:curators] synonym: "vesicular hydrogen:amino acid antiporter activity" EXACT [] is_obsolete: true [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetylcholine from one side of a membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: reactome:R-HSA-264615 "Loading of acetylcholine in synaptic vesicle" is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:1901375 ! acetate ester transmembrane transporter activity [Term] id: GO:0005278 name: acetylcholine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:hydrogen antiporter activity" EXACT [] is_a: GO:0005277 ! acetylcholine transmembrane transporter activity is_a: GO:0015307 ! drug:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005280 name: amino acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] synonym: "cation/amino acid symporter" BROAD [] synonym: "hydrogen:amino acid symporter activity" EXACT [] xref: reactome:R-HSA-8875623 "SLC25A18,A22 cotransport Glu, H+ from cytosol to mitochondrial matrix" is_a: GO:0005416 ! amino acid:cation symporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005281 name: obsolete general amino acid permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "general amino acid permease activity" EXACT [] synonym: "general amino acid transporter" BROAD [] is_obsolete: true replaced_by: GO:0015171 [Term] id: GO:0005283 name: amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005284 alt_id: GO:0005285 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "insulin-activated sodium/amino acid transporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid symporter activity" NARROW [] synonym: "insulin-activated sodium:amino acid transporter activity" NARROW [] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "sodium/amino acid transporter activity" BROAD [] synonym: "sodium/excitatory amino acid cotransporter activity" BROAD [] synonym: "sodium/excitatory amino acid symporter activity" EXACT [] synonym: "sodium:amino acid symporter activity" EXACT [] synonym: "sodium:amino acid transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" NARROW [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005416 ! amino acid:cation symporter activity [Term] id: GO:0005287 name: high-affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity basic amino acid transmembrane transporter activity" EXACT [] synonym: "high-affinity basic amino acid transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity [Term] id: GO:0005289 name: high-affinity arginine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arginine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity arginine transmembrane transporter activity" EXACT [] synonym: "high-affinity arginine transporter activity" BROAD [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity [Term] id: GO:0005290 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity [Term] id: GO:0005291 name: high-affinity L-histidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity histidine permease activity" RELATED [] synonym: "high affinity L-histidine transmembrane transporter activity" EXACT [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0005290 ! L-histidine transmembrane transporter activity [Term] id: GO:0005292 name: high-affinity lysine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lysine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity lysine transmembrane transporter activity" EXACT [] synonym: "high affinity lysine transporter activity" BROAD [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015189 ! L-lysine transmembrane transporter activity [Term] id: GO:0005294 name: neutral L-amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "neutral L-amino acid porter activity" RELATED [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005295 name: neutral amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005282 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "sodium/neutral amino acid transporter" BROAD [] is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0005297 name: proline:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] synonym: "hydrogen/proline transporter" BROAD [] is_a: GO:0005280 ! amino acid:proton symporter activity [Term] id: GO:0005298 name: proline:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] synonym: "sodium/proline symporter activity" EXACT [] xref: reactome:R-HSA-444100 "PROT mediates L-proline uptake" xref: RHEA:28967 is_a: GO:0005283 ! amino acid:sodium symporter activity [Term] id: GO:0005300 name: high-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "high-affinity tryptophan transporter activity" BROAD [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0005301 name: obsolete valine/tyrosine/tryptophan permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] synonym: "valine/tyrosine/tryptophan permease activity" EXACT [] is_obsolete: true consider: GO:0005302 consider: GO:0005304 consider: GO:0015196 consider: GO:0022857 [Term] id: GO:0005302 name: L-tyrosine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015508 def: "Enables the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-tyrosine permease activity" EXACT [] synonym: "L-tyrosine transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0005304 name: L-valine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-valine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0005307 name: choline:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015220 ! choline transmembrane transporter activity [Term] id: GO:0005308 name: creatine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of creatine from one side of a membrane to the other. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0005309 name: creatine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] xref: reactome:R-HSA-200396 "Creatine transport across the plasma membrane" is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0005308 ! creatine transmembrane transporter activity [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Enables the transfer of dicarboxylic acids from one side of a membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: reactome:R-HSA-1614546 "Sulfate is exported to the cytosol in exchange for dicarboxylate" xref: reactome:R-HSA-372843 "malate [mitochondrial matrix] + orthophosphate [cytosol] <=> malate [cytosol] + orthophosphate [mitochondrial matrix]" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0005311 name: obsolete sodium:dicarboxylate/tricarboxylate symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" EXACT [] is_obsolete: true consider: GO:0005310 consider: GO:0005343 consider: GO:0015142 [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: reactome:R-HSA-210444 "L-Glutamate loading of synaptic vesicle" xref: reactome:R-HSA-428052 "SLC17A6,7,8 exchange cytosolic L-Glu for synaptic vesicle H+" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0005314 name: high-affinity glutamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glutamate from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transporter activity" BROAD [] xref: reactome:R-HSA-428015 "SLC1A1,2,3,6,7 cotransport L-Glu,L-Asp,D-Asp,H+,3Na+ from extracellular region to cytosol" is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015501 ! glutamate:sodium symporter activity [Term] id: GO:0005315 name: inorganic phosphate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005317 def: "Enables the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0005316 name: high-affinity inorganic phosphate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.20.2.2] synonym: "high affinity inorganic phosphate:sodium symporter activity" EXACT [] synonym: "sodium/phosphate cotransporter activity" BROAD [] is_a: GO:0005436 ! sodium:phosphate symporter activity [Term] id: GO:0005318 name: obsolete phosphate:hydrogen symporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] synonym: "phosphate:hydrogen symporter" EXACT [] synonym: "phosphate:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015317 [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of or within a cell, or between cells." [GOC:ai] synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: reactome:R-HSA-1369028 "ABCAs mediate lipid efflux" xref: reactome:R-HSA-1369052 "ABCAs mediate lipid influx" xref: reactome:R-HSA-174786 "ApoB-48 + 40 triacylglycerol + 60 phospholipid => ApoB-48:TG:PL complex" xref: reactome:R-HSA-5682285 "ABCA12 transports lipids from cytosol to extracellular region" xref: reactome:R-HSA-5683714 "ABCA3 transports PC, PG from ER membrane to lamellar body" xref: reactome:R-HSA-6801250 "TRIAP1:PRELID1, PRELID3A transports PA from the outer to the inner mitochondrial membrane" xref: reactome:R-HSA-8848053 "ABCA5 transports CHOL from lysosomal lumen to cytosol" xref: reactome:R-HSA-8866329 "MTTP lipidates APOB-100, forming a pre-VLDL" is_a: GO:0005215 ! transporter activity [Term] id: GO:0005320 name: obsolete apolipoprotein namespace: molecular_function alt_id: GO:0015907 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "apolipoprotein" EXACT [] is_obsolete: true consider: GO:0005319 [Term] id: GO:0005321 name: obsolete high-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "HDL" EXACT [] synonym: "high-density lipoprotein" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005322 name: obsolete low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "LDL" EXACT [] synonym: "low-density lipoprotein" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005323 name: obsolete very-low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "very-low-density lipoprotein" EXACT [] synonym: "VLDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005324 name: long-chain fatty acid transporter activity namespace: molecular_function alt_id: GO:0005325 alt_id: GO:0008562 def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, ISBN:0198506732] synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47] synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] synonym: "peroxisomal fatty acyl CoA transporter activity" NARROW [GOC:curators] synonym: "peroxisomal fatty-acyl-CoA transmembrane transporter activity" NARROW [] synonym: "peroxisomal fatty-acyl-CoA transporter activity" NARROW [] synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] xref: EC:3.6.3.47 xref: reactome:R-HSA-2046087 "Translocation of tetracosahexaenoyl-CoA to peroxisomes" xref: reactome:R-HSA-2046093 "Translocation of tetracosapentaenoyl-CoA to peroxisomes" xref: reactome:R-HSA-382575 "ABCD1-3 dimers transfer LCFAs from cytosol to peroxisomal matrix" xref: reactome:R-HSA-390393 "Peroxisomal uptake of very long-chain fatty acyl CoA" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0005326 name: neurotransmitter transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of or within a cell, or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732] synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah] xref: reactome:R-HSA-374896 "Uptake of Noradrenaline" xref: reactome:R-HSA-374919 "Noradrenaline clearance from the synaptic cleft" is_a: GO:0005215 ! transporter activity [Term] id: GO:0005328 name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] synonym: "sodium/neurotransmitter symporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005330 name: dopamine:sodium symporter activity namespace: molecular_function alt_id: GO:0005329 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) + Cl-(out)= dopamine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.3] comment: Merge terms, see https://github.com/geneontology/go-ontology/issues/16054 synonym: "dopamine transmembrane transporter activity" EXACT [] synonym: "dopamine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/dopamine symporter activity" EXACT [] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0005332 name: gamma-aminobutyric acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" EXACT [] synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] xref: reactome:R-HSA-444007 "GAT1-3 mediate Na+/Cl- dependent GABA transport" is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0005334 name: norepinephrine:sodium symporter activity namespace: molecular_function alt_id: GO:0005333 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) + Cl-(out) = norepinephrine(in) + Na+(in) + Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.2] synonym: "levarterenol transporter activity" EXACT [] synonym: "noradrenaline transporter activity" EXACT [] synonym: "norepinephrine transmembrane transporter activity" EXACT [] synonym: "norepinephrine:sodium symporter activity" EXACT [] synonym: "norepinephrine:sodium:chloride symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter activity" EXACT [] xref: reactome:R-HSA-443997 "SLC6A2 cotransports NAd, Na+ from extracellular region to cytosol" xref: Wikipedia:Norepinephrine_transporter is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0005335 name: serotonin:sodium symporter activity namespace: molecular_function alt_id: GO:0005336 alt_id: GO:0015222 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) + Cl-(out) = serotonin(in) + Na+(in)+ Cl-(in)." [PMID:21752877, PMID:22519513, TC:2.A.22.1.1] synonym: "serotonin transmembrane transporter activity" EXACT [] synonym: "serotonin:sodium:chloride symporter activity" EXACT [] synonym: "sodium/serotonin symporter activity" EXACT [] xref: reactome:R-HSA-444008 "SLC6A4 co-transports 5HT, Cl-, Na+ from extracellular region to cytosol" is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0005337 name: nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] xref: reactome:R-HSA-109527 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" xref: reactome:R-HSA-109529 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 2" xref: reactome:R-HSA-109534 "Equilibrative transport (export) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" xref: reactome:R-HSA-109536 "Equilibrative transport (import) of nucleosides and free bases by solute carrier family 29 (nucleoside transporters), member 1" xref: reactome:R-HSA-727740 "Equilibrative transport (import) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" xref: reactome:R-HSA-727749 "SLC29A3 transports nucleosides from lysosomal lumen to cytosol" xref: reactome:R-HSA-727767 "SLC29A3 transports nucleosides from cytosol to lysosomal lumen" xref: reactome:R-HSA-727768 "Equilibrative transport (export) of adenosine and biogenic amines by solute carrier family 29 (nucleoside transporters), member 4" is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0005338 name: nucleotide-sugar transmembrane transporter activity namespace: molecular_function alt_id: GO:0005339 def: "Enables the transfer of a nucleotide-sugar from one side of a membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] xref: reactome:R-HSA-744230 "SLC35D2 mediates the antiport of GDP-mannose in exchange for GMP" xref: reactome:R-HSA-744231 "SLC35D2 exchanges UDP-sugars for UMP" is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0005340 name: nucleotide-sulfate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005341 def: "Enables the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] synonym: "nucleotide-sulphate transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic acids from one side of a membrane to the other. Organic acids are acidic compound containing carbon in covalent linkage," [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0005343 name: organic acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: reactome:R-HSA-8876312 "SLC5A12 cotransports Na+ with LACT, PYR, NCA from extracellular region to cytosol" is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005344 name: oxygen carrier activity namespace: molecular_function alt_id: GO:0015033 def: "Enables the directed movement of oxygen into, out of or within a cell, or between cells." [GOC:ai] synonym: "globin" NARROW [] synonym: "hemerythrin" NARROW [] synonym: "hemocyanin" NARROW [] synonym: "oxygen-carrying" NARROW [] is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0005345 name: purine nucleobase transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26386, ISBN:0198506732] synonym: "purine base transmembrane transporter activity" EXACT [GOC:go_curators] synonym: "purine transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015205 ! nucleobase transmembrane transporter activity [Term] id: GO:0005346 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0005347 name: ATP transmembrane transporter activity namespace: molecular_function alt_id: GO:0005348 def: "Enables the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0005350 name: pyrimidine nucleobase transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [CHEBI:26432, GOC:ai] synonym: "pyrimidine base transmembrane transporter activity" EXACT [GOC:go_curators] synonym: "pyrimidine transmembrane transporter activity" RELATED [GOC:curators] is_a: GO:0015205 ! nucleobase transmembrane transporter activity [Term] id: GO:0005351 name: carbohydrate:proton symporter activity namespace: molecular_function alt_id: GO:0005403 alt_id: GO:0015542 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] synonym: "cation/sugar symporter activity" BROAD [] synonym: "hydrogen:sugar symporter activity" EXACT [] synonym: "hydrogen:sugar transporter activity" BROAD [] synonym: "lactose/glucose efflux transporter activity" NARROW [] synonym: "proton:sugar symporter activity" EXACT [] synonym: "sugar efflux transmembrane transporter activity" BROAD [PMID:20971900] synonym: "sugar porter activity" RELATED [] synonym: "sugar transporter" BROAD [] synonym: "sugar:hydrogen ion symporter activity" EXACT [] synonym: "sugar:hydrogen symporter activity" EXACT [] synonym: "sugar:proton symporter activity" NARROW [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005352 name: alpha-glucoside:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] synonym: "alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005353 name: fructose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015585 alt_id: GO:0019192 def: "Enables the transfer of fructose from one side of a membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "fructose permease activity" EXACT [] synonym: "fructose porter activity" EXACT [] xref: reactome:R-HSA-189222 "SLC2A5 transports fructose from extracellular region to cytosol" is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005354 name: galactose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of galactose from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005355 name: glucose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015579 def: "Enables the transfer of the hexose monosaccharide glucose from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "glucose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: reactome:R-HSA-499981 "Transport of Extracellular Glucose to the Cytosol by GLUT1 and GLUT2" xref: reactome:R-HSA-5653873 "SLC2A1 tetramer transports Glc from cytosol to Golgi lumen" is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0005356 name: glucose:proton symporter activity namespace: molecular_function alt_id: GO:0005361 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "hydrogen:glucose symporter activity" EXACT [] synonym: "hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen:glucose symporter activity" NARROW [] synonym: "transepithelial hydrogen:glucose transporter activity" RELATED [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0009679 ! hexose:proton symporter activity [Term] id: GO:0005357 name: obsolete constitutive glucose:proton symporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] comment: The reason for obsoletion is that the constitutive aspect of the transporter is unlikely to be an aspect of the activity, but instead it probably relates to the expression level of the transporter. synonym: "constitutive hydrogen/glucose transporter activity" BROAD [] synonym: "constitutive hydrogen:glucose symporter activity" EXACT [] synonym: "constitutive hydrogen:glucose transporter activity" BROAD [] is_obsolete: true [Term] id: GO:0005358 name: high-affinity glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "high-affinity hydrogen:glucose symporter activity" EXACT [] synonym: "high-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005359 name: low-affinity glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "low-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "low-affinity hydrogen:glucose symporter activity" EXACT [] synonym: "low-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005360 name: insulin-responsive glucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + H(out)+ = glucose(in) + H(in)+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "insulin-responsive hydrogen:glucose symporter activity" EXACT [] synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] is_a: GO:0005356 ! glucose:proton symporter activity [Term] id: GO:0005362 name: low-affinity glucose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] xref: reactome:R-HSA-429567 "Co-transport (influx) of glucose/mannose and Na+ ions by SGLT4" is_a: GO:0005412 ! glucose:sodium symporter activity [Term] id: GO:0005363 name: maltose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015581 def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "maltose porter activity" EXACT [] xref: RHEA:33171 is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0005364 name: maltose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] synonym: "hydrogen/maltose transporter activity" BROAD [] synonym: "maltose permease" BROAD [] synonym: "maltose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0005363 ! maltose transmembrane transporter activity [Term] id: GO:0005365 name: myo-inositol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of myo-inositol from one side of a membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] synonym: "vitamin Bh transporter activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0005366 name: myo-inositol:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:hydrogen symporter activity" EXACT [] xref: reactome:R-HSA-429101 "HMIT co-transports myo-inositol with a proton" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0005367 name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter activity" BROAD [] xref: reactome:R-HSA-429663 "SLC5A3 (SMIT1) transports myo-inositol (Ins) with Na+ from extracellular region to cytosol" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005368 name: taurine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of taurine from one side of a membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] xref: RHEA:14613 is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0005369 name: taurine:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005368 ! taurine transmembrane transporter activity [Term] id: GO:0005371 name: tricarboxylate secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0005370 def: "Enables the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0815340729] synonym: "tricarboxylate carrier activity" EXACT [] is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005372 name: water transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of water (H2O) from one side of a membrane to the other." [GOC:ai] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0005373 name: obsolete heavy metal ion porter activity namespace: molecular_function def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "heavy metal ion porter activity" EXACT [] synonym: "metal ion transporter" BROAD [] is_obsolete: true consider: GO:0015291 consider: GO:0046873 [Term] id: GO:0005375 name: copper ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005378 alt_id: GO:0005379 alt_id: GO:0005380 alt_id: GO:0015088 def: "Enables the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] synonym: "copper uptake transmembrane transporter activity" RELATED [] synonym: "intracellular copper ion transporter" NARROW [] synonym: "plasma membrane copper transporter" NARROW [] xref: reactome:R-HSA-437300 "SLC31A1 transports Cu2+ from extracellular region to cytosol" xref: RHEA:28703 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005376 name: obsolete plasma membrane copper transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "plasma membrane copper transporter" EXACT [] is_obsolete: true consider: GO:0005375 consider: GO:0005886 [Term] id: GO:0005377 name: obsolete intracellular copper ion transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "intracellular copper ion transporter" EXACT [] synonym: "intracellular copper transporter" EXACT [] is_obsolete: true consider: GO:0005375 consider: GO:0005622 [Term] id: GO:0005381 name: iron ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005382 alt_id: GO:0016033 def: "Enables the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] synonym: "iron transporter activity" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: reactome:R-HSA-435349 "SLC11A2 cotransports Fe2+, H+ from extracellular region to cytosol" xref: reactome:R-HSA-904830 "SLC40A1:CP:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: reactome:R-HSA-917936 "MCOLN1 transports Fe2+ from endosome lumen to cytosol" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005384 name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:dgf] xref: reactome:R-HSA-8959798 "SLC30A10 transports Mn2+ from cytosol to extracellular region" is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0005385 name: zinc ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:dgf] synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] synonym: "zinc, iron permease activity" NARROW [] xref: reactome:R-HSA-435366 "ZnT1 mediates the efflux of zinc from the cell" xref: reactome:R-HSA-435375 "ZnT2 facilitates zinc vesicular sequestration" xref: reactome:R-HSA-437084 "ZnT3 transports zinc into synaptic vesicles" xref: reactome:R-HSA-437085 "ZnT5 transports zinc into secretory granules in pancreatic beta cells" xref: reactome:R-HSA-437129 "ZnT7 transports zinc into the golgi apparatus" xref: reactome:R-HSA-437136 "SLC30A8 transports Zn2+ from cytosol to secretory granule" xref: reactome:R-HSA-437139 "ZnT6 transports zinc into the golgi apparatus" xref: reactome:R-HSA-442317 "ZIP6 and ZIP14 mediate zinc influx into cells" xref: reactome:R-HSA-442345 "hZIP10 mediates zinc influx into cells" xref: reactome:R-HSA-442387 "ZIP8 mediates zinc influx into cells" xref: reactome:R-HSA-442393 "ZIP7 mediates zinc efflux from the endoplasmic reticulum" xref: reactome:R-HSA-442405 "hZIP5 mediates zinc uptake by cells" xref: reactome:R-HSA-442422 "SLC39A1-4 transports Zn2+ from extracellular region to cytosol" xref: RHEA:29351 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0005388 name: calcium-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8] synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "calcium ABC transporter" NARROW [] synonym: "calcium efflux ATPase" NARROW [] synonym: "calcium pump" BROAD [] synonym: "calcium transporting ATPase activity" EXACT [] synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8] synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8] synonym: "sarcoplasmic reticulum ATPase" NARROW [] xref: EC:3.6.3.8 xref: MetaCyc:3.6.3.8-RXN xref: reactome:R-HSA-418309 "ATP2B1-4 transport cytosolic Ca2+ to extracellular region" xref: reactome:R-HSA-418365 "ATP2A1-3 transport cytosolic Ca2+ to dense tubular network lumen" xref: reactome:R-HSA-427910 "ATP2A1-3 transport Ca2+ from cytosol to ER lumen" xref: reactome:R-HSA-936883 "ATP2C1/2:Mg2+ transport cytosolic Ca2+ to Golgi lumen" xref: RHEA:18105 is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0005391 name: sodium:potassium-exchanging ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9] synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-pump" RELATED [EC:3.6.3.9] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:3.6.3.9 xref: MetaCyc:3.6.3.9-RXN xref: reactome:R-HSA-936897 "ATP1A:ATP1B:FXYD exchanges Na+ for K+" xref: RHEA:18353 is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0005395 name: eye pigment precursor transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] xref: reactome:R-HSA-1467466 "ABCA4 mediates atRAL transport" xref: reactome:R-HSA-2466749 "ABCA4 transports NRPE from photoreceptor outer segment membrane to cytosol" is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0005396 name: obsolete transmembrane conductance regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. synonym: "transmembrane conductance regulator activity" EXACT [] is_obsolete: true consider: GO:0043267 [Term] id: GO:0005400 name: obsolete peroxisomal membrane transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "peroxisomal membrane transporter" EXACT [] is_obsolete: true consider: GO:0005215 consider: GO:0005777 [Term] id: GO:0005402 name: carbohydrate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] synonym: "cation/sugar symporter activity" EXACT [] synonym: "cation:sugar symporter activity" EXACT [] synonym: "sugar:cation symporter activity" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005412 name: glucose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] synonym: "sodium/glucose symporter activity" EXACT [] xref: reactome:R-HSA-189208 "SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol" xref: reactome:R-HSA-429613 "SLC5As, NAGLT1 cotransport Glc and Na+ from extracellular region to cytosol" xref: reactome:R-HSA-8932955 "SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol" is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005415 name: nucleoside:sodium symporter activity namespace: molecular_function alt_id: GO:0008522 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] synonym: "nucleoside-sodium cotransporter activity" BROAD [] synonym: "sodium-dependent nucleoside transporter activity" BROAD [] xref: reactome:R-HSA-109530 "Concentrative transport (import) of a nucleoside and a sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 1" xref: reactome:R-HSA-109538 "Concentrative transport (import) of a nucleoside and two sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 3" xref: reactome:R-HSA-109539 "Concentrative transport (import) of nucleosides plus sodium ions by solute carrier family 28 (sodium-coupled nucleoside transporter), member 2" is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005416 name: amino acid:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] synonym: "cation/amino acid symporter activity" EXACT [] synonym: "cation:amino acid symporter activity" EXACT [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005427 name: proton-dependent oligopeptide secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] synonym: "hydrogen/oligopeptide symporter" RELATED [] synonym: "proton-dependent oligopeptide transporter activity" EXACT [] is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity [Term] id: GO:0005429 name: obsolete chromaffin granule amine transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of amines across chromaffin granule membranes." [GOC:mah] comment: The term was obsoleted because its intended usage was unclear: chromaffin granules are dense core secretory vesicles (PMID:20853344) so whatever they transport must be by secretion. is_obsolete: true [Term] id: GO:0005430 name: obsolete synaptic vesicle amine transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of amines across synaptic vesicle membranes." [GOC:ai] comment: The class was obsoleted because the cellular location of a function should not be part of the class label. is_obsolete: true consider: GO:0005275 [Term] id: GO:0005432 name: calcium:sodium antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] synonym: "sodium/calcium exchanger" EXACT [] synonym: "sodium:calcium exchange" RELATED [] xref: reactome:R-HSA-425661 "SLC8A1,2,3 exchange 3Na+ for Ca2+" xref: reactome:R-HSA-8949688 "SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" xref: reactome:R-HSA-8949703 "SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity [Term] id: GO:0005436 name: sodium:phosphate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] synonym: "sodium/phosphate symporter activity" EXACT [] xref: reactome:R-HSA-2872498 "SLC17A3-1 cotransports extracellular Na+ and Pi to cytosol" is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005451 name: monovalent cation:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] synonym: "monovalent cation:hydrogen antiporter activity" EXACT [] xref: reactome:R-HSA-2889070 "SLC9B2 exchanges Na+, Li+ for H+" is_a: GO:0015299 ! solute:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005452 name: inorganic anion exchanger activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: inorganic anion A(out) + inorganic anion B(in) = inorganic anion A(in) + inorganic anion B(out)." [GOC:mah] xref: reactome:R-HSA-1237038 "SLC4A1 exchanges cytosolic HCO3- for extracellular Cl-" xref: reactome:R-HSA-1247665 "Band 3 Anion Exchanger (AE1, SLC4A1) exchanges cytosolic chloride for extracellular bicarbonate" xref: reactome:R-HSA-425482 "SLC4A1,2,3 exchanges HCO3- for Cl-" xref: reactome:R-HSA-425577 "Na+-driven Cl-/HCO3- exchanger transport" xref: reactome:R-HSA-427666 "SLC26A3,6 exchange Cl- for HCO3-" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005456 name: CMP-N-acetylneuraminate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a CMP-N-acetylneuraminate from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "CMP-sialic acid transmembrane transporter activity" BROAD [] xref: reactome:R-HSA-727807 "SLC35A1 exchanges CMP-Neu5Ac for CMP" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005457 name: GDP-fucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a GDP-fucose from one side of a membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-742345 "SLC35C1 transport UDP-Fuc from cytosol to Golgi lumen" is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005458 name: GDP-mannose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a GDP-mannose from one side of a membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0036080 ! purine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005459 name: UDP-galactose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-galactose from one side of a membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-735702 "SLC35A2 exchanges UDP-Gal, UDP-GalNAc for UMP" is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005460 name: UDP-glucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-glucose from one side of a membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005461 name: UDP-glucuronic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-glucuronic acid from one side of a membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-174368 "SLC35D1 hexamer transports UDP-GlcA, UDP-GlcNAc from cytosol to endoplasmic reticulum lumen" is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005462 name: UDP-N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a UDP-N-acetylglucosamine from one side of a membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-741450 "SLC35A3 exchanges UDP-GlcNAc for UMP" xref: reactome:R-HSA-742354 "SLC35B4 mediates the transport of UDP-N-acetylglucosamine into the Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005463 name: UDP-N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005464 name: UDP-xylose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of UDP-xylose from one side of a membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] xref: reactome:R-HSA-742373 "SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015165 ! pyrimidine nucleotide-sugar transmembrane transporter activity [Term] id: GO:0005468 name: obsolete small-molecule carrier or transporter namespace: molecular_function alt_id: GO:0005453 alt_id: GO:0005454 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not provide a useful functional classification. synonym: "small-molecule carrier or transporter" EXACT [] is_obsolete: true consider: GO:0005215 [Term] id: GO:0005469 name: succinate:fumarate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] is_a: GO:0015138 ! fumarate transmembrane transporter activity is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0005471 name: ATP:ADP antiporter activity namespace: molecular_function alt_id: GO:0005349 def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] synonym: "adenine nucleotide translocase" EXACT [] synonym: "ADP/ATP carrier protein" EXACT [] synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] is_a: GO:0005347 ! ATP transmembrane transporter activity is_a: GO:0015217 ! ADP transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0005476 name: carnitine:acyl carnitine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] synonym: "carnitine/acyl carnitine carrier activity" EXACT [] synonym: "carnitine:acyl carnitine carrier activity" EXACT [] synonym: "fatty acyl carnitine carrier" EXACT [] is_a: GO:0015297 ! antiporter activity [Term] id: GO:0005477 name: pyruvate secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "pyruvate carrier activity" RELATED [] is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0050833 ! pyruvate transmembrane transporter activity [Term] id: GO:0005479 name: obsolete vacuolar assembly namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vacuolar assembly" EXACT [] is_obsolete: true replaced_by: GO:0007033 [Term] id: GO:0005480 name: obsolete vesicle transport namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle transport" EXACT [] is_obsolete: true replaced_by: GO:0016192 [Term] id: GO:0005481 name: obsolete vesicle fusion namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle fusion" EXACT [] is_obsolete: true consider: GO:0006906 consider: GO:0007086 consider: GO:0016189 consider: GO:0016192 consider: GO:0019817 [Term] id: GO:0005482 name: obsolete vesicle targeting namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "vesicle targeting" EXACT [] is_obsolete: true consider: GO:0006903 consider: GO:0016080 [Term] id: GO:0005483 name: soluble NSF attachment protein activity namespace: molecular_function def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] comment: Added parent see https://github.com/geneontology/go-ontology/issues/16807 synonym: "SNAP" EXACT [] is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] subset: goslim_chembl synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732] comment: Note that this term is in the subset of terms that should not be used for direct, manual gene product annotation. Please choose a more specific child term, or request a new one if no suitable term is available. For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: gocheck_do_not_manually_annotate subset: goslim_pir subset: goslim_plant synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005489 name: obsolete electron transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] comment: This term was made obsolete because the activity described by the definition does not exist. synonym: "class I cytochrome c" RELATED [] synonym: "class II cytochrome c" RELATED [] synonym: "class IIa cytochrome c" RELATED [] synonym: "class IIb cytochrome c" RELATED [] synonym: "class III cytochrome c" RELATED [] synonym: "class IV cytochrome c" RELATED [] synonym: "cytochrome b" RELATED [] synonym: "cytochrome b5" RELATED [] synonym: "cytochrome c3 (tetraheme)" RELATED [] synonym: "cytochrome c554" RELATED [] synonym: "cytochrome c7 (triheme)" RELATED [] synonym: "cytochrome d" RELATED [] synonym: "diheme class I cytochrome c" RELATED [] synonym: "electron transfer carrier" RELATED [] synonym: "electron transporter activity" EXACT [] synonym: "flavin-containing electron transporter" RELATED [] synonym: "flavodoxin" RELATED [] synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] synonym: "monoheme class I cytochrome c" RELATED [] synonym: "nonaheme cytochrome c" RELATED [] synonym: "respiratory chain cytochrome b6" RELATED [] synonym: "Rieske iron-sulfur protein" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0005490 name: obsolete cytochrome P450 namespace: molecular_function def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] comment: This term was made obsolete because its definition was changed and because it represents a gene product. synonym: "cytochrome P450" EXACT [] is_obsolete: true [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0008289 ! lipid binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0005497 name: androgen binding namespace: molecular_function def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [CHEBI:50113, GOC:jl] is_a: GO:0042562 ! hormone binding [Term] id: GO:0005499 name: vitamin D binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [CHEBI:27300, GOC:mah, ISBN:0471331309] synonym: "calciferol binding" NARROW [] synonym: "cholecalciferol binding" NARROW [] synonym: "ergocalciferol binding" NARROW [] is_a: GO:0005496 ! steroid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005500 name: juvenile hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005501 name: retinoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732] xref: reactome:R-HSA-2454113 "RBP3 transports 11cRAL to rod photoreceptor outer segment" xref: reactome:R-HSA-2464809 "RBP3 regulates the transport of atROL from ROS to RPE" xref: reactome:R-HSA-2465934 "11cROL translocates from Muller cells to cone photoreceptor cells" xref: reactome:R-HSA-2465938 "RBP3 regulates atROL taken up by Muller cells" is_a: GO:0019840 ! isoprenoid binding [Term] id: GO:0005502 name: 11-cis retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [CHEBI:16066] synonym: "11-cis retinaldehyde binding" EXACT [] synonym: "11-cis-retinal binding" NARROW [CHEBI:16066] synonym: "vitamin A binding" BROAD [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005503 name: all-trans retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [CHEBI:17898, GOC:curators] synonym: "all-trans retinaldehyde binding" EXACT [] synonym: "trans retinal binding" EXACT [] synonym: "visual yellow binding" EXACT [] synonym: "vitamin A binding" BROAD [] synonym: "xanthopsin" RELATED [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0005505 name: obsolete heavy metal binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal binding" EXACT [] is_obsolete: true consider: GO:0046872 [Term] id: GO:0005506 name: iron ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] synonym: "iron binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005507 name: copper ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] synonym: "copper binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005508 name: obsolete copper/cadmium binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a composite function. synonym: "copper/cadmium binding" EXACT [] is_obsolete: true consider: GO:0005507 consider: GO:0046870 [Term] id: GO:0005509 name: calcium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] synonym: "calcium ion storage activity" RELATED [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0005513 name: detection of calcium ion namespace: biological_process def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "Ca2+ ion detection" EXACT [] synonym: "calcium ion detection" EXACT [] synonym: "calcium ion sensing" EXACT [] synonym: "detection of Ca2+ ion" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051592 ! response to calcium ion [Term] id: GO:0005514 name: obsolete calcium ion storage activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "calcium ion storage activity" EXACT [] is_obsolete: true consider: GO:0005509 consider: GO:0051208 [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0001948 alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "glycoprotein binding" NARROW [] synonym: "protein amino acid binding" EXACT [] xref: reactome:R-HSA-170835 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3" xref: reactome:R-HSA-170846 "TGFBR2 recruits TGFBR1" xref: reactome:R-HSA-3645786 "TGFBR2 mutant dimers recruit TGFBR1" xref: reactome:R-HSA-3656484 "TGFBR2 recruits TGFBR1 KD Mutants" xref: reactome:R-HSA-3702153 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 MH2 domain mutants" xref: reactome:R-HSA-3713560 "An anchoring protein, ZFYVE9 (SARA), recruits SMAD2/3 phosphorylation motif mutants" is_a: GO:0005488 ! binding [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0005517 name: obsolete calmodulin inhibitor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'. synonym: "calmodulin inhibitor activity" EXACT [] is_obsolete: true consider: GO:0005516 [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0005519 name: cytoskeletal regulatory protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732] subset: goslim_chembl synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005521 name: lamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732] synonym: "lamin/chromatin binding" BROAD [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005522 name: profilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544] is_a: GO:0005515 ! protein binding [Term] id: GO:0005523 name: tropomyosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [GOC:curators, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732] xref: reactome:R-HSA-265682 "KCNJ11 tetramer:ABCC8 tetramer binds 4xATP, closing the channel" is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005525 name: GTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] xref: reactome:R-HSA-167429 "The receptor:G-protein complex binds GTP" is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0035639 ! purine ribonucleoside triphosphate binding [Term] id: GO:0005527 name: macrolide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0005528 name: FK506 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 23-membered macrolide lactone FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] is_a: GO:0005527 ! macrolide binding [Term] id: GO:0005530 name: obsolete lectin namespace: molecular_function def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [GOC:curators] comment: This term was made obsolete because it refers to a class of gene products. synonym: "lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0030246 [Term] id: GO:0005531 name: obsolete galactose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "galactose binding lectin" EXACT [] is_obsolete: true consider: GO:0005534 consider: GO:0007157 [Term] id: GO:0005532 name: obsolete mannose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mannose binding lectin" EXACT [] synonym: "mannose receptor" RELATED [] is_obsolete: true consider: GO:0005537 consider: GO:0007157 [Term] id: GO:0005533 name: obsolete N-acetylgalactosamine lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "N-acetylgalactosamine lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0046871 [Term] id: GO:0005534 name: galactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [CHEBI:28260, GOC:jl, ISBN:0198506732] synonym: "galactose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005536 name: glucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [CHEBI:17234, GOC:jl] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [CHEBI:37684, GOC:jl, ISBN:0192800981] subset: goslim_chembl synonym: "mannose binding lectin" RELATED [] xref: reactome:R-HSA-947991 "Transport of glycoproteins with Man8 (or Man9) N-glycans to the Golgi" is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [CHEBI:16336, GOC:jl] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0005541 name: obsolete acyl-CoA or acyl binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was replaced by more appropriate terms. synonym: "acyl-CoA or acyl binding" EXACT [] is_obsolete: true consider: GO:0000035 consider: GO:0000062 [Term] id: GO:0005542 name: folic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732] synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0033218 ! amide binding is_a: GO:0072341 ! modified amino acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0005543 name: phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732] is_a: GO:0008289 ! lipid binding is_a: GO:0043168 ! anion binding [Term] id: GO:0005544 name: calcium-dependent phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0005545 name: 1-phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732] is_a: GO:0035091 ! phosphatidylinositol binding [Term] id: GO:0005546 name: phosphatidylinositol-4,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate binding" EXACT [CHEBI:18348] synonym: "phosphatidylinositol 4,5-bisphosphate binding" EXACT [GOC:ebc] synonym: "PIP2 binding" BROAD [CHEBI:18348] synonym: "PtdIns(4,5)P2 binding" EXACT [GOC:bf] is_a: GO:1902936 ! phosphatidylinositol bisphosphate binding [Term] id: GO:0005547 name: phosphatidylinositol-3,4,5-trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] synonym: "PIP3 binding" EXACT [GOC:bf] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0005548 name: phospholipid transporter activity namespace: molecular_function alt_id: GO:0008497 def: "Enables the directed movement of phospholipids into, out of or within a cell, or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732] xref: reactome:R-HSA-216757 "4xPALM-C-p-2S-ABCA1 tetramer transports PL from transport vesicle membrane to plasma membrane" xref: reactome:R-HSA-382553 "ABCA7:Apo1A-mediated phospholipid efflux" xref: reactome:R-HSA-5678706 "ABCB4 transports PC from plasma membrane to extracellular region" xref: reactome:R-HSA-8857662 "ESYT1:ESYT2:ESYT3 transport GPL from plasma membrane to ER membrane" xref: reactome:R-HSA-8865637 "MFSD2A transports LPC from extracellular region to plasma membrane" xref: reactome:R-HSA-8867876 "OSBPL5,8,10 exchange PS with PI4P from ER membrane to plasma membrane" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0005549 name: odorant binding namespace: molecular_function def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0005550 name: pheromone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] is_a: GO:0005549 ! odorant binding [Term] id: GO:0005551 name: obsolete ubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0016567 consider: GO:0031386 [Term] id: GO:0005552 name: obsolete polyubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "polyubiquitin" EXACT [] is_obsolete: true consider: GO:0000209 [Term] id: GO:0005553 name: obsolete ubiquitin-ribosomal protein fusion protein namespace: molecular_function def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732] comment: This term was made obsolete because it describes a gene product. synonym: "ubiquitin-ribosomal protein fusion protein" EXACT [] is_obsolete: true [Term] id: GO:0005555 name: obsolete blood group antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "blood group antigen" EXACT [] is_obsolete: true [Term] id: GO:0005557 name: obsolete lymphocyte antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "lymphocyte antigen" EXACT [] is_obsolete: true [Term] id: GO:0005558 name: obsolete minor histocompatibility antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "minor histocompatibility antigen" EXACT [] is_obsolete: true [Term] id: GO:0005559 name: obsolete ribozyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "ribozyme" EXACT [] is_obsolete: true [Term] id: GO:0005561 name: obsolete nucleic acid namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "nucleic acid" EXACT [] is_obsolete: true [Term] id: GO:0005562 name: obsolete RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "RNA" EXACT [] is_obsolete: true [Term] id: GO:0005563 name: obsolete transfer RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "transfer RNA" EXACT [] is_obsolete: true replaced_by: GO:0030533 [Term] id: GO:0005564 name: obsolete cytosolic tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "cytosolic tRNA" EXACT [] is_obsolete: true [Term] id: GO:0005565 name: obsolete mitochondrial tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "mitochondrial tRNA" EXACT [] is_obsolete: true [Term] id: GO:0005566 name: obsolete ribosomal RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "ribosomal RNA" EXACT [] is_obsolete: true consider: GO:0003735 consider: GO:0005840 [Term] id: GO:0005567 name: obsolete cytosolic ribosomal RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "cytosolic ribosomal RNA" EXACT [] is_obsolete: true [Term] id: GO:0005568 name: obsolete mitochondrial rRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "mitochondrial rRNA" EXACT [] is_obsolete: true [Term] id: GO:0005569 name: obsolete small nucleolar RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. synonym: "small nucleolar RNA" EXACT [] is_obsolete: true consider: GO:0030555 [Term] id: GO:0005570 name: obsolete small nuclear RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. synonym: "small nuclear RNA" EXACT [] is_obsolete: true consider: GO:0000375 consider: GO:0017069 [Term] id: GO:0005571 name: obsolete untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "untranslated RNA" EXACT [] is_obsolete: true [Term] id: GO:0005572 name: obsolete RNA polymerase II transcribed untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "RNA polymerase II transcribed untranslated RNA" EXACT [] is_obsolete: true [Term] id: GO:0005573 name: obsolete telomerase RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a gene product. synonym: "telomerase RNA" EXACT [] is_obsolete: true replaced_by: GO:0000332 [Term] id: GO:0005574 name: obsolete DNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. synonym: "DNA" EXACT [] is_obsolete: true [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "A location, relative to cellular compartments and structures, occupied by a macromolecular machine when it carries out a molecular function. There are two ways in which the gene ontology describes locations of gene products: (1) relative to cellular structures (e.g., cytoplasmic side of plasma membrane) or compartments (e.g., mitochondrion), and (2) the stable macromolecular complexes of which they are parts (e.g., the ribosome)." [GOC:pdt, NIF_Subcellular:sao-1337158144] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. When this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell or subcellular entity" EXACT [] synonym: "cellular component" EXACT [] synonym: "subcellular entity" RELATED [NIF_Subcellular:nlx_subcell_100315] xref: NIF_Subcellular:sao-1337158144 xref: NIF_Subcellular:sao1337158144 [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005579 name: membrane attack complex namespace: cellular_component def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X, ISBN:0781735149] synonym: "MAC" EXACT [] synonym: "membrane attack complex protein alphaM chain" NARROW [] synonym: "membrane attack complex protein beta2 chain" NARROW [] synonym: "TCC" EXACT [] synonym: "terminal complement complex" EXACT [] xref: Wikipedia:Complement_membrane_attack_complex is_a: GO:0046930 ! pore complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005580 name: obsolete membrane attack complex protein alphaM chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "membrane attack complex protein alphaM chain" EXACT [] is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0005581 name: collagen trimer namespace: cellular_component def: "A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers typically assemble into higher order structures." [GOC:dos, GOC:mah, ISBN:0721639976, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0005582 name: collagen type XV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes where it bridges between fibrils." [PMID:11158616, PMID:11937714, PMID:21421911] is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005583 name: fibrillar collagen trimer namespace: cellular_component def: "Any triple helical collagen trimer that forms fibrils." [GOC:mah, ISBN:0721639976, PMID:21421911] is_a: GO:0005581 ! collagen trimer is_a: GO:0044420 ! extracellular matrix component relationship: part_of GO:0098643 ! banded collagen fibril [Term] id: GO:0005584 name: collagen type I trimer namespace: cellular_component def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976] xref: Wikipedia:Collagen_type_I is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005585 name: collagen type II trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005586 name: collagen type III trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005587 name: collagen type IV trimer namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form 3 dimensional nets within basement membranes." [ISBN:0721639976, PMID:19693541, PMID:21421911] xref: Wikipedia:Collagen_type_IV is_a: GO:0098642 ! network-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005588 name: collagen type V trimer namespace: cellular_component def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005589 name: collagen type VI trimer namespace: cellular_component def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976, PMID:19693541, PMID:21421911] is_a: GO:0005581 ! collagen trimer relationship: part_of GO:0098647 ! collagen beaded filament [Term] id: GO:0005590 name: collagen type VII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue. It binds laminin." [ISBN:0721639976, PMID:19693541] is_a: GO:0030934 ! anchoring collagen complex relationship: part_of GO:0098652 ! collagen type VII anchoring fibril [Term] id: GO:0005591 name: collagen type VIII trimer namespace: cellular_component def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976, PMID:21421911] is_a: GO:0005598 ! short-chain collagen trimer is_a: GO:0030935 ! sheet-forming collagen trimer is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0005592 name: collagen type XI trimer namespace: cellular_component def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen trimer [Term] id: GO:0005593 name: FACIT collagen trimer namespace: cellular_component def: "A collagen trimer that associates with collagen fibrils and consists of collagen monomers that contain two or more relatively short triple-helical domains connected by non-triple-helical sequences." [ISBN:0198599587, PMID:21421911] comment: The acronym FACIT stands for fibril-associated collagen with interrupted triple helix. xref: Wikipedia:FACIT_collagen is_a: GO:0005581 ! collagen trimer [Term] id: GO:0005594 name: collagen type IX trimer namespace: cellular_component def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer [Term] id: GO:0005595 name: collagen type XII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer is_a: GO:0030934 ! anchoring collagen complex [Term] id: GO:0005596 name: collagen type XIV trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen trimer is_a: GO:0030934 ! anchoring collagen complex [Term] id: GO:0005597 name: collagen type XVI trimer namespace: cellular_component def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] is_a: GO:0005593 ! FACIT collagen trimer [Term] id: GO:0005598 name: short-chain collagen trimer namespace: cellular_component def: "Any collagen trimer that does not form fibrils and that is relatively short compared to the collagen trimers that do form fibrils." [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer [Term] id: GO:0005599 name: collagen type X trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices form hexagonal networks (sheets)." [ISBN:0721639976, PMID:21421911] comment: Collagen X trimers have been observed to form hexagonal lattices in vitro, but in vivo they have been found in a fibril associated form (PMID:19693541). is_a: GO:0005598 ! short-chain collagen trimer is_a: GO:0030935 ! sheet-forming collagen trimer [Term] id: GO:0005600 name: collagen type XIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XIII) chains; type XIII collagen triple helices span the plasma membrane." [GOC:bhm, GOC:dos, ISBN:0721639976] is_a: GO:0030936 ! transmembrane collagen trimer [Term] id: GO:0005601 name: classical-complement-pathway C3/C5 convertase complex namespace: cellular_component def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005602 name: complement component C1 complex namespace: cellular_component def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149] synonym: "complement component C1q complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005603 name: obsolete complement component C2 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entity corresponding to "complement C2 complex". synonym: "complement component C2 complex" EXACT [] is_obsolete: true [Term] id: GO:0005604 name: basement membrane namespace: cellular_component alt_id: GO:0005605 alt_id: GO:0008003 def: "A collagen-containing extracellular matrix consisting of a thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684, PMID:22505934] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. synonym: "basal lamina" RELATED [] synonym: "basement lamina" RELATED [] synonym: "lamina densa" RELATED [] xref: Wikipedia:Basement_membrane is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005606 name: laminin-1 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-111 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005607 name: laminin-2 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-211 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005608 name: laminin-3 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] synonym: "laminin-121 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005609 name: laminin-4 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-221 complex" EXACT [GOC:dph, PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005610 name: laminin-5 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-332 complex" NARROW [GOC:dph, PMID:15979864] synonym: "laminin-3A32 complex" EXACT [PMID:15979864] synonym: "laminin-5A complex" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005611 name: laminin-6 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-311 complex" EXACT [GOC:dph, PMID:15979864] synonym: "laminin-6A complex" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005612 name: laminin-7 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] synonym: "laminin-321 complex" NARROW [GOC:dph, PMID:15979864] synonym: "laminin-7A" EXACT [PMID:15979864] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005613 name: obsolete laminin receptor protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. synonym: "laminin receptor protein" EXACT [] is_obsolete: true consider: GO:0008305 [Term] id: GO:0005614 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] is_a: GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism that are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0044421 ! extracellular region part [Term] id: GO:0005616 name: larval serum protein complex namespace: cellular_component def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005617 name: obsolete larval serum protein-1 namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "larval serum protein-1" EXACT [] synonym: "LSP1" EXACT [] is_obsolete: true [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, most prokaryotic cells and some protozoan parasites, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan; in protozoan parasites such as Giardia species, it's made of carbohydrates and proteins." [GOC:giardia, http://en.wikipedia.org/wiki/Microbial_cyst, ISBN:0198547684, PMID:15134259] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0005619 name: ascospore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] synonym: "fungal-type spore wall" BROAD [GOC:mah] is_a: GO:0009277 ! fungal-type cell wall is_a: GO:0031160 ! spore wall [Term] id: GO:0005621 name: cellular bud scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732] subset: gocheck_do_not_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0044464 ! cell part [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component [Term] id: GO:0005624 name: obsolete membrane fraction namespace: cellular_component def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "membrane fraction" EXACT [] is_obsolete: true consider: GO:0016020 [Term] id: GO:0005625 name: obsolete soluble fraction namespace: cellular_component def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "soluble" BROAD [] synonym: "soluble fraction" EXACT [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0005626 name: obsolete insoluble fraction namespace: cellular_component def: "OBSOLETE: That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "insoluble fraction" EXACT [] synonym: "particle-bound" RELATED [] is_obsolete: true consider: GO:0005575 [Term] id: GO:0005627 name: obsolete ascus namespace: cellular_component def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] comment: This term was made obsolete because it is a structure that contains cell (ascospores) rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. synonym: "ascus" EXACT [] is_obsolete: true [Term] id: GO:0005628 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] synonym: "forespore membrane" RELATED [] synonym: "FSM" EXACT [] is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0005630 name: dityrosine layer of spore wall namespace: cellular_component def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005631 name: chitosan layer of spore wall namespace: cellular_component def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005632 name: inner layer of spore wall namespace: cellular_component def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005633 name: ascus lipid droplet namespace: cellular_component def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] synonym: "ascus lipid particle" EXACT [GOC:curators] is_a: GO:0005811 ! lipid droplet [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] synonym: "horsetail nucleus" NARROW [GOC:al, GOC:mah, GOC:vw, PMID:15030757] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope is_a: GO:0044428 ! nuclear part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005637 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] synonym: "inner nuclear membrane" EXACT [GOC:kmv, GOC:vw, PMID:21411627] xref: NIF_Subcellular:sao1612527463 is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031965 ! nuclear membrane [Term] id: GO:0005638 name: lamin filament namespace: cellular_component def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] synonym: "type V intermediate filament" EXACT [] is_a: GO:0005882 ! intermediate filament is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005652 ! nuclear lamina [Term] id: GO:0005639 name: integral component of nuclear inner membrane namespace: cellular_component def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] synonym: "integral to nuclear inner membrane" NARROW [] is_a: GO:0031229 ! intrinsic component of nuclear inner membrane is_a: GO:0031301 ! integral component of organelle membrane [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "outer envelope" BROAD [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005641 name: nuclear envelope lumen namespace: cellular_component alt_id: GO:0005653 def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "nuclear intermembrane space" EXACT [] synonym: "nuclear membrane lumen" RELATED [] synonym: "perinuclear space" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005642 name: annulate lamellae namespace: cellular_component def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] is_a: GO:0044464 ! cell part is_a: GO:0098589 ! membrane region relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005643 name: nuclear pore namespace: cellular_component alt_id: GO:0005644 def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] synonym: "nucleopore" EXACT [GOC:al, PMID:7603572] xref: NIF_Subcellular:sao220861693 xref: Wikipedia:Nuclear_pore is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005645 name: obsolete RAN-binding protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "RAN-binding protein" EXACT [] is_obsolete: true replaced_by: GO:0008536 consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005646 name: obsolete importin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin" EXACT [] synonym: "karyopherin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005647 name: obsolete importin, alpha-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin, alpha-subunit" EXACT [] synonym: "karyopherin-alpha" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005648 name: obsolete importin, beta-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "importin, beta-subunit" EXACT [] synonym: "karyopherin-beta1" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005649 name: obsolete transportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta2" EXACT [] synonym: "transportin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005650 name: obsolete importin, alpha-subunit transport factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "CAS" RELATED [] synonym: "importin, alpha-subunit transport factor" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005651 name: obsolete exportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "exportin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 consider: GO:0017056 [Term] id: GO:0005652 name: nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732, ISBN:0716731363] xref: NIF_Subcellular:sao1455996588 xref: Wikipedia:Nuclear_lamina is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005655 name: nucleolar ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "nucleolar RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0005656 name: nuclear pre-replicative complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "eukaryotic pre-replicative complex" EXACT [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-RC" RELATED [] synonym: "pre-replicative complex" BROAD [GOC:bf, GOC:bhm, GOC:jh2] is_a: GO:0036387 ! pre-replicative complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005657 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] synonym: "replication focus" RELATED [] xref: Wikipedia:Replication_fork is_a: GO:0044427 ! chromosomal part [Term] id: GO:0005658 name: alpha DNA polymerase:primase complex namespace: cellular_component def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] synonym: "DNA polymerase alpha:primase complex" EXACT [] synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] synonym: "pol-prim" RELATED [] synonym: "primosome" BROAD [] is_a: GO:0044454 ! nuclear chromosome part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005660 name: obsolete delta-DNA polymerase cofactor complex namespace: cellular_component def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl] comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. synonym: "delta DNA polymerase cofactor complex" EXACT [] synonym: "delta-DNA polymerase cofactor complex" EXACT [] is_obsolete: true consider: GO:0005663 consider: GO:0043626 [Term] id: GO:0005662 name: DNA replication factor A complex namespace: cellular_component def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] xref: Wikipedia:Replication_protein_A is_a: GO:0032991 ! protein-containing complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005663 name: DNA replication factor C complex namespace: cellular_component def: "A complex that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase. In eukaryotes the complex consists of five polypeptides." [PMID:14614842, PMID:14646196, PMID:16172520] subset: goslim_pir synonym: "activator 1 complex" EXACT [] synonym: "RFC complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0005664 name: nuclear origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] synonym: "eukaryotic ORC" EXACT [] synonym: "nuclear ORC" EXACT [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0005665 name: RNA polymerase II, core complex namespace: cellular_component def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase II, core complex" EXACT [] synonym: "RNA polymerase II complex" BROAD [] synonym: "RNAP II complex" BROAD [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005666 name: RNA polymerase III complex namespace: cellular_component def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase III activity" RELATED [] synonym: "DNA-directed RNA polymerase III complex" EXACT [] is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005667 name: transcription factor complex namespace: cellular_component def: "A protein complex that is capable of associating with DNA by direct binding, or via other DNA-binding proteins or complexes, and regulating transcription." [GOC:jl] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005668 name: RNA polymerase transcription factor SL1 complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654] synonym: "selectivity factor SL1 complex" EXACT [GOC:mah] synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0005669 name: transcription factor TFIID complex namespace: cellular_component def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005670 name: obsolete transcription-activating factor, 30kD namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "transcription-activating factor, 30kD" EXACT [] is_obsolete: true replaced_by: GO:0005669 [Term] id: GO:0005671 name: Ada2/Gcn5/Ada3 transcription activator complex namespace: cellular_component alt_id: GO:0002928 def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. Contains either GCN5 or PCAF in a mutually exclusive manner. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins. Both ATAC- or SAGA (see GO:0000124, SAGA complex) are involved in the acetylation of histone H3K9 and K14 residues." [PMID:10637607] comment: In human, this complex is composed of GCN5 or PCAF, ADA2a, ADA3, ZZZ3, ATAC2, SGF29, HCF1, WDR5,YEATS2, NC2-beta, and MBIP. synonym: "Ada Two-A containing complex" EXACT [GOC:rl, PMID:18838386] synonym: "Ada-Two-A-containing complex" EXACT [] synonym: "ATAC complex" EXACT [GOC:rl, PMID:18838386] is_a: GO:1902562 ! H4 histone acetyltransferase complex [Term] id: GO:0005672 name: transcription factor TFIIA complex namespace: cellular_component def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005673 name: transcription factor TFIIE complex namespace: cellular_component def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005674 name: transcription factor TFIIF complex namespace: cellular_component def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005675 name: transcription factor TFIIH holo complex namespace: cellular_component def: "A complex that is capable of kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. It is composed of the core TFIIH complex and the TFIIK complex." [GOC:ew, GOC:krc, PMID:14500720, PMID:22308316, PMID:22572993, PMID:7813015] synonym: "holo TFIIH complex" EXACT [] is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex is_a: GO:0044451 ! nucleoplasm part is_a: GO:0090575 ! RNA polymerase II transcription factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0005677 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] is_a: GO:0090568 ! nuclear transcriptional repressor complex [Term] id: GO:0005678 name: obsolete chromatin assembly complex namespace: cellular_component def: "OBSOLETE: Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. synonym: "chromatin assembly complex" EXACT [] synonym: "nucleosome assembly complex" NARROW [] is_obsolete: true consider: GO:0031497 [Term] id: GO:0005680 name: anaphase-promoting complex namespace: cellular_component def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, GOC:vw, PMID:10465783, PMID:10611969] comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. synonym: "anaphase promoting complex" EXACT [] synonym: "APC" BROAD [] synonym: "cyclosome" EXACT [] xref: Wikipedia:Anaphase-promoting_complex is_a: GO:0000152 ! nuclear ubiquitin ligase complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0005681 name: spliceosomal complex namespace: cellular_component def: "Any of a series of ribonucleoprotein complexes that contain snRNA(s) and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the spliceosomal splicing of one or more substrate RNAs, and which also contain the RNA substrate(s) from the initial target RNAs of splicing, the splicing intermediate RNA(s), to the final RNA products. During cis-splicing, the initial target RNA is a single, contiguous RNA transcript, whether mRNA, snoRNA, etc., and the released products are a spliced RNA and an excised intron, generally as a lariat structure. During trans-splicing, there are two initial substrate RNAs, the spliced leader RNA and a pre-mRNA." [GOC:editors, GOC:mah, ISBN:0198547684, PMID:19239890] subset: goslim_pir synonym: "spliceosome" BROAD [] synonym: "spliceosome complex" EXACT [] xref: Wikipedia:Spliceosome is_a: GO:0044428 ! nuclear part is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005682 name: U5 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] synonym: "snRNP U5" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005683 name: U7 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] synonym: "snRNP U7" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005684 name: U2-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] comment: A U2-type complex refers to any of the snRNP-based complexes that form during splicing that uses U2 (as opposed to U12). There are complexes that form during U2-splicing that don't necessarily contain the U2 snRNP. synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005685 name: U1 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah] synonym: "snRNP U1" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005686 name: U2 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] comment: U2 snRNP refers to the U2 small nuclear RNA and the proteins that associate with it. U2 snRNP is not considered to be a type of spliceosomal complex by itself. synonym: "17S U2 snRNP" NARROW [] synonym: "snRNP U2" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005687 name: U4 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah] synonym: "snRNP U4" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005688 name: U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah] synonym: "snRNP U6" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005689 name: U12-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah] synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah] xref: Wikipedia:Minor_spliceosome is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005690 name: U4atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah] synonym: "snRNP U4atac" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005691 name: U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah] synonym: "snRNP U6atac" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005692 name: U11 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah] synonym: "12S U11 snRNP" NARROW [] synonym: "snRNP U11" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005693 name: U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah] synonym: "snRNP U12" EXACT [GOC:mah] is_a: GO:0097525 ! spliceosomal snRNP complex [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] comment: Chromosomes include parts that are not part of the chromatin. Examples include the kinetochore. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005695 name: obsolete chromatid namespace: cellular_component def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732] comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. synonym: "chromatid" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 consider: GO:0005694 [Term] id: GO:0005696 name: obsolete telomere namespace: cellular_component def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732, PMID:11352055] comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. synonym: "telomere" EXACT [] is_obsolete: true consider: GO:0000781 consider: GO:0000782 [Term] id: GO:0005697 name: telomerase holoenzyme complex namespace: cellular_component def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] subset: goslim_pir is_a: GO:0044428 ! nuclear part is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005698 name: obsolete centromere namespace: cellular_component def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732] comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization. synonym: "centromere" EXACT [] is_obsolete: true consider: GO:0000775 [Term] id: GO:0005700 name: polytene chromosome namespace: cellular_component def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732] xref: Wikipedia:Polytene_chromosome is_a: GO:0005694 ! chromosome [Term] id: GO:0005701 name: polytene chromosome chromocenter namespace: cellular_component def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome chromocentre" EXACT [] is_a: GO:0010369 ! chromocenter relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005702 name: polytene chromosome weak point namespace: cellular_component def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] synonym: "constriction" BROAD [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005703 name: polytene chromosome puff namespace: cellular_component def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005704 name: polytene chromosome band namespace: cellular_component def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005705 name: polytene chromosome interband namespace: cellular_component def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] is_a: GO:0098687 ! chromosomal region relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005706 name: polytene chromosome ectopic fiber namespace: cellular_component def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome ectopic fibre" EXACT [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005707 name: obsolete interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "interphase chromosome" EXACT [] is_obsolete: true consider: GO:0005694 [Term] id: GO:0005708 name: obsolete mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. synonym: "mitotic chromosome" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005709 name: obsolete prophase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "prophase chromosome" EXACT [] is_obsolete: true consider: GO:0005694 [Term] id: GO:0005710 name: obsolete metaphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. synonym: "metaphase chromosome" EXACT [] is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005711 name: obsolete meiotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. synonym: "meiotic chromosome" EXACT [] is_obsolete: true consider: GO:0000794 [Term] id: GO:0005712 name: chiasma namespace: cellular_component def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732] xref: Wikipedia:Chiasma_(genetics) is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005713 name: recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005714 name: early recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005715 name: late recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005719 name: nuclear euchromatin namespace: cellular_component def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000791 ! euchromatin [Term] id: GO:0005720 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin [Term] id: GO:0005721 name: pericentric heterochromatin namespace: cellular_component def: "Heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [PMID:12019236, PMID:20206496, PMID:22729156] synonym: "centric heterochromatin" EXACT [] synonym: "centromeric heterochromatin" EXACT [GOC:dph] is_a: GO:0000792 ! heterochromatin relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0005722 name: beta-heterochromatin namespace: cellular_component def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] is_a: GO:0005721 ! pericentric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005723 name: alpha-heterochromatin namespace: cellular_component def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] is_a: GO:0005721 ! pericentric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005724 name: nuclear telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0031933 ! telomeric heterochromatin relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0005725 name: intercalary heterochromatin namespace: cellular_component def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] is_a: GO:0005720 ! nuclear heterochromatin [Term] id: GO:0005726 name: perichromatin fibrils namespace: cellular_component def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0005727 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: goslim_metagenomics is_a: GO:0044424 ! intracellular part relationship: part_of GO:0046821 ! extrachromosomal DNA [Term] id: GO:0005728 name: extrachromosomal rDNA circle namespace: cellular_component def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] synonym: "extrachromosomal ribosomal DNA circle" EXACT [] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005729 name: 2-micrometer circle DNA namespace: cellular_component def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005731 name: nucleolus organizer region namespace: cellular_component def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] synonym: "NOR" EXACT [] synonym: "nucleolus organiser region" EXACT [] synonym: "nucleolus organizer complex" RELATED [] xref: Wikipedia:Nucleolus_organizer_region is_a: GO:0030874 ! nucleolar chromatin is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0005732 name: small nucleolar ribonucleoprotein complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the small nucleolar RNA (snoRNA) family and associated proteins. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] comment: Note that 'nucleolar' in the term name is part of the RNA family designation 'small nucleolar', and does not necessarily reflect the location of the complex. subset: goslim_pir synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005733 name: obsolete small nucleolar RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "small nucleolar RNA" EXACT [] synonym: "snoRNA" EXACT [] is_obsolete: true [Term] id: GO:0005734 name: obsolete box C + D snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "box C + D snoRNP protein" EXACT [] is_obsolete: true [Term] id: GO:0005735 name: obsolete box H + ACA snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "box H + ACA snoRNP protein" EXACT [] is_obsolete: true [Term] id: GO:0005736 name: RNA polymerase I complex namespace: cellular_component def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase I activity" RELATED [] synonym: "DNA-directed RNA polymerase I complex" EXACT [] is_a: GO:0044452 ! nucleolar part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoplasm is_a: GO:0044424 ! intracellular part [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [GOC:giardia, ISBN:0198506732] comment: Some anaerobic or microaerophilic organisms (e.g. Entamoeba histolytica, Giardia intestinalis and several Microsporidia species) do not have mitochondria, and contain mitochondrion-related organelles (MROs) instead, called mitosomes or hydrogenosomes, very likely derived from mitochondria. To annotate gene products located in these mitochondrial relics in species such as Entamoeba histolytica, Giardia intestinalis or others, please use GO:0032047 'mitosome' or GO:0042566 'hydrogenosome'. (See PMID:24316280 for a list of species currently known to contain mitochondrion-related organelles.) subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "outer mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane [Term] id: GO:0005742 name: mitochondrial outer membrane translocase complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] synonym: "GIP complex" NARROW [PMID:23201437] synonym: "TOM complex" EXACT [PMID:23201437] is_a: GO:0098799 ! outer mitochondrial membrane protein complex [Term] id: GO:0005743 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] synonym: "inner mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1371347282 xref: Wikipedia:Inner_mitochondrial_membrane is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031966 ! mitochondrial membrane [Term] id: GO:0005744 name: TIM23 mitochondrial import inner membrane translocase complex namespace: cellular_component def: "The protein transport machinery of the mitochondrial inner membrane that typically transports proteins that possess a matrix-targeting N-terminal presequence. The TIM23 complex contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:27554484, PMID:8851659] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. subset: goslim_pir synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane presequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane translocase complex" BROAD [] synonym: "Tim23 complex" EXACT [] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0005745 name: m-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [GOC:mcc, PMID:12417197, PMID:21147776] is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:1905368 ! peptidase complex relationship: part_of GO:0031305 ! integral component of mitochondrial inner membrane [Term] id: GO:0005746 name: mitochondrial respirasome namespace: cellular_component alt_id: GO:0097249 def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] comment: Merged and changed label as requested\nhttps://github.com/geneontology/go-ontology/issues/12846 synonym: "mitochondrial electron transport chain" EXACT [] synonym: "mitochondrial respirasome" RELATED [] synonym: "mitochondrial respiratory chain" EXACT [] synonym: "mitochondrial respiratory chain supercomplex" EXACT [] synonym: "mitochondrial respiratory supercomplex" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0070469 ! respirasome relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005747 name: mitochondrial respiratory chain complex I namespace: cellular_component alt_id: GO:0005748 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045271 ! respiratory chain complex I is_a: GO:0098800 ! inner mitochondrial membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005749 name: mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone) namespace: cellular_component alt_id: GO:0008136 alt_id: GO:0009362 alt_id: GO:0019738 alt_id: GO:0030390 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, GOC:vw, ISBN:0198547684] synonym: "mitochondrial fumarate reductase complex" EXACT [] is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045283 ! fumarate reductase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005750 name: mitochondrial respiratory chain complex III namespace: cellular_component alt_id: GO:0015008 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial coenzyme Q-cytochrome c oxidoreductase complex" EXACT [] synonym: "mitochondrial coenzyme Q-cytochrome c reductase complex" EXACT [] synonym: "mitochondrial complex III" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc] synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc] is_a: GO:0045275 ! respiratory chain complex III is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005751 name: mitochondrial respiratory chain complex IV namespace: cellular_component alt_id: GO:0005752 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0045277 ! respiratory chain complex IV is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0005746 ! mitochondrial respirasome [Term] id: GO:0005753 name: mitochondrial proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0016470 def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] synonym: "mitochondrial respiratory chain complex V" EXACT [] is_a: GO:0045259 ! proton-transporting ATP synthase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0005754 name: mitochondrial proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005755 name: obsolete hydrogen-transporting ATP synthase, coupling factor CF(0) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "hydrogen-transporting ATP synthase, coupling factor CF(0)" EXACT [] is_obsolete: true consider: GO:0045263 [Term] id: GO:0005756 name: mitochondrial proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk is_a: GO:0098800 ! inner mitochondrial membrane protein complex relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005757 name: mitochondrial permeability transition pore complex namespace: cellular_component def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol. The pore complex is formed of the voltage-dependent anion channel (VDAC), the adenine nucleotide translocase (ANT) and cyclophilin-D (CyP-D)." [PMID:10393078] synonym: "mitochondrial PT pore complex" EXACT [] synonym: "MPTP complex" EXACT [] synonym: "PTPC" BROAD [PMID:21760595] is_a: GO:0046930 ! pore complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005758 name: mitochondrial intermembrane space namespace: cellular_component alt_id: GO:0031971 def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: NIF_Subcellular:sao118944228 is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component alt_id: GO:0031980 def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732] synonym: "mitochondrial lumen" EXACT [] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao-1899375636 xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0044429 ! mitochondrial part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005760 name: gamma DNA polymerase complex namespace: cellular_component def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005762 name: mitochondrial large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] synonym: "39S ribosomal subunit, mitochondrial" NARROW [] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005763 name: mitochondrial small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] synonym: "28S ribosomal subunit, mitochondrial" NARROW [] synonym: "mitochondrial ribosomal small subunit complex" EXACT [] synonym: "mitochondrial ribosomal SSU complex" EXACT [] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] synonym: "lysosome membrane" EXACT [] is_a: GO:0098852 ! lytic vacuole membrane relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005767 name: secondary lysosome namespace: cellular_component def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, ISBN:0815316194] xref: NIF_Subcellular:sao1549842807 is_a: GO:0005764 ! lysosome [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A vacuole to which materials ingested by endocytosis are delivered." [ISBN:0198506732, PMID:19696797] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005769 name: early endosome namespace: cellular_component def: "A membrane-bounded organelle that receives incoming material from primary endocytic vesicles that have been generated by clathrin-dependent and clathrin-independent endocytosis; vesicles fuse with the early endosome to deliver cargo for sorting into recycling or degradation pathways." [GOC:mah, NIF_Subcellular:nlx_subcell_20090701, PMID:19696797] xref: NIF_Subcellular:nlx_subcell_20090701 is_a: GO:0005768 ! endosome [Term] id: GO:0005770 name: late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [NIF_Subcellular:nlx_subcell_20090702, PMID:11964142, PMID:2557062] synonym: "prevacuolar compartment" EXACT [] synonym: "PVC" BROAD [] xref: NIF_Subcellular:nlx_subcell_20090702 is_a: GO:0005768 ! endosome [Term] id: GO:0005771 name: multivesicular body namespace: cellular_component def: "A type of endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881, PMID:16533950] synonym: "multivesicular endosome" EXACT [PMID:12122203] synonym: "MVB" EXACT [] synonym: "MVE" EXACT [PMID:12122203] xref: NIF_Subcellular:sao2045955158 is_a: GO:0005770 ! late endosome [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] is_a: GO:0044437 ! vacuolar part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732] is_a: GO:0044437 ! vacuolar part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005776 name: autophagosome namespace: cellular_component def: "A double-membrane-bounded compartment that engulfs endogenous cellular material as well as invading microorganisms to target them to the lytic vacuole/lysosome for degradation as part of macroautophagy." [GOC:autophagy, ISBN:0198547684, PMID:11099404] synonym: "autophagic vacuole" EXACT [NIF_Subcellular:sao8663416959] synonym: "initial autophagic vacuole" RELATED [NIF_Subcellular:sao8663416959] xref: NIF_Subcellular:sao8663416959 is_a: GO:0005773 ! vacuole [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism." [GOC:pm, PMID:9302272, UniProtKB-KW:KW-0576] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisomal" RELATED [GOC:curators] synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0042579 ! microbody [Term] id: GO:0005778 name: peroxisomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] synonym: "peroxisome membrane" EXACT [] is_a: GO:0031903 ! microbody membrane is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005779 name: integral component of peroxisomal membrane namespace: cellular_component def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:mah] synonym: "integral to peroxisomal membrane" NARROW [] is_a: GO:0031231 ! intrinsic component of peroxisomal membrane is_a: GO:0031301 ! integral component of organelle membrane [Term] id: GO:0005780 name: extrinsic component of intraperoxisomal membrane namespace: cellular_component def: "The component of the intraperoxisomal membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] synonym: "extrinsic to intraperoxisomal membrane" EXACT [] synonym: "intra-peroxisomal peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044439 ! peroxisomal part relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0005781 name: obsolete peroxisome targeting signal receptor complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. synonym: "peroxisome targeting signal receptor complex" EXACT [] is_obsolete: true consider: GO:0000268 consider: GO:0006625 consider: GO:0044439 [Term] id: GO:0005782 name: peroxisomal matrix namespace: cellular_component alt_id: GO:0031909 def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] synonym: "peroxisomal lumen" EXACT [] is_a: GO:0031907 ! microbody lumen is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005784 name: Sec61 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647] synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex [Term] id: GO:0005785 name: signal recognition particle receptor complex namespace: cellular_component def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732] synonym: "docking protein complex" RELATED [] synonym: "SR complex" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0005786 name: signal recognition particle, endoplasmic reticulum targeting namespace: cellular_component alt_id: GO:0005855 def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732] synonym: "signal sequence receptor complex" EXACT [] synonym: "SRP" EXACT [] xref: Wikipedia:Signal_recognition_particle is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0005787 name: signal peptidase complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex is_a: GO:1905368 ! peptidase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0005788 name: endoplasmic reticulum lumen namespace: cellular_component alt_id: GO:0016022 def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "endoplasmic reticulum cisterna" EXACT [] synonym: "ER cisterna" EXACT [] synonym: "ER lumen" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005789 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] is_a: GO:0031090 ! organelle membrane is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0042175 ! nuclear outer membrane-endoplasmic reticulum membrane network [Term] id: GO:0005790 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (smooth ER or SER) has no ribosomes attached to it. The smooth ER is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732] synonym: "SER" EXACT [] synonym: "smooth ER" EXACT [] xref: NIF_Subcellular:sao710427438 xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005791 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732] synonym: "RER" EXACT [] synonym: "rough ER" EXACT [] xref: NIF_Subcellular:sao1881364067 xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum [Term] id: GO:0005792 name: obsolete microsome namespace: cellular_component def: "OBSOLETE: Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "microsomal membrane" RELATED [] synonym: "microsome" EXACT [] xref: Wikipedia:Microsome is_obsolete: true consider: GO:0043231 [Term] id: GO:0005793 name: endoplasmic reticulum-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi and Golgi-to-ER transport." [GOC:pr, PMID:16723730] synonym: "EGTC" EXACT [] synonym: "endoplasmic reticulum-Golgi transport container" EXACT [] synonym: "ER-Golgi intermediate compartment" EXACT [] synonym: "ER-Golgi transport container" EXACT [] synonym: "ERGIC" EXACT [] synonym: "pre-Golgi intermediate compartment" EXACT [] synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster] synonym: "VTC" EXACT [] xref: Wikipedia:Vesicular-tubular_cluster is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005795 name: Golgi stack namespace: cellular_component alt_id: GO:0016940 def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] is_a: GO:0098791 ! Golgi subcompartment [Term] id: GO:0005796 name: Golgi lumen namespace: cellular_component def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005797 name: Golgi medial cisterna namespace: cellular_component def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] synonym: "vesicular component" RELATED [NIF_Subcellular:sao138219748] xref: NIF_Subcellular:sao819927218 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0005799 name: obsolete coatomer namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. synonym: "coatomer" EXACT [] synonym: "COPI vesicle" RELATED [] is_obsolete: true consider: GO:0030126 consider: GO:0030137 [Term] id: GO:0005800 name: obsolete COPII vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "COPII vesicle" EXACT [] is_obsolete: true consider: GO:0030134 [Term] id: GO:0005801 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732, ISBN:0815316194] comment: The CGN is not considered part of the Golgi apparatus but is a separate organelle. synonym: "cis face" BROAD [NIF_Subcellular:sao632188024] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] xref: NIF_Subcellular:sao632188024 is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005802 name: trans-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] comment: There are different opinions about whether the TGN should be considered part of the Golgi apparatus or not. We follow Alberts et al, 1994 (ISBN:0815316194), who consider it to be a part. synonym: "Golgi trans face" RELATED [] synonym: "Golgi trans-face" RELATED [] synonym: "late Golgi" RELATED [GOC:mah] synonym: "maturing face" RELATED [] synonym: "TGN" EXACT [] synonym: "trans face" BROAD [NIF_Subcellular:sao1039242387] synonym: "trans Golgi network" EXACT [] xref: NIF_Subcellular:sao9456487 is_a: GO:0098791 ! Golgi subcompartment [Term] id: GO:0005803 name: obsolete secretory vesicle namespace: cellular_component def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] comment: This term was made obsolete because it was being used to describe two different components. synonym: "secretory vesicle" EXACT [] synonym: "transition vesicle" NARROW [] is_obsolete: true consider: GO:0030133 consider: GO:0030141 [Term] id: GO:0005804 name: obsolete secretory vesicle membrane namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its parent was made obsolete. synonym: "secretory vesicle membrane" EXACT [] is_obsolete: true consider: GO:0030658 consider: GO:0030667 [Term] id: GO:0005805 name: obsolete ER-Golgi transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "ER-Golgi transport vesicle" EXACT [] is_obsolete: true consider: GO:0030134 [Term] id: GO:0005806 name: obsolete Golgi-ER transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "Golgi-ER transport vesicle" EXACT [] is_obsolete: true consider: GO:0030142 [Term] id: GO:0005808 name: obsolete Golgi-plasma membrane transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. synonym: "Golgi-plasma membrane transport vesicle" EXACT [] is_obsolete: true consider: GO:0030133 [Term] id: GO:0005809 name: obsolete Golgi-vacuole transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "Golgi-vacuole transport vesicle" EXACT [] is_obsolete: true consider: GO:0030133 [Term] id: GO:0005810 name: obsolete endocytotic transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. synonym: "endocytotic transport vesicle" EXACT [] is_obsolete: true replaced_by: GO:0030139 [Term] id: GO:0005811 name: lipid droplet namespace: cellular_component def: "An intracellular non-membrane-bounded organelle comprising a matrix of coalesced lipids surrounded by a phospholipid monolayer. May include associated proteins." [GOC:mah, GOC:tb] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_chembl subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid particle" EXACT [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005813 name: centrosome namespace: cellular_component def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] subset: goslim_pir xref: Wikipedia:Centrosome is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0005814 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] comment: In most eukaryotic cells, 'ciliary basal body' (GO:0036064) and 'centriole' (GO:0005814) represent a common entity that cycles through its function in cell division, then ciliogenesis, then cell division again. However, these structures are modified extensively as they transition into each other, and may contain different proteins, specific to each component. synonym: "daughter centriole" NARROW [GOC:cilia] synonym: "mother centriole" NARROW [GOC:cilia] xref: NIF_Subcellular:sao95019936 xref: Wikipedia:Centriole is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "An intracellular structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [GOC:vw, http://en.wikipedia.org/wiki/Microtubule_organizing_center, ISBN:0815316194, PMID:17072892, PMID:17245416] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005816 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] synonym: "SPB" EXACT [GOC:mah] xref: Wikipedia:Spindle_pole_body is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0005817 name: obsolete centrosomal mitotic factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt] comment: This term was made obsolete because it was not defined. synonym: "centrosomal mitotic factor" EXACT [] is_obsolete: true [Term] id: GO:0005818 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part is_a: GO:0099080 ! supramolecular complex relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005821 name: intermediate layer of spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005822 name: inner plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005823 name: central plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005824 name: outer plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005825 name: half bridge of spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005826 name: actomyosin contractile ring namespace: cellular_component alt_id: GO:0030480 def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. In animal cells, the contractile ring is located at the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, GOC:vw, ISBN:0805319409, ISBN:0815316194, PMID:28914606] synonym: "actomyosin ring" RELATED [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "cytokinetic ring" RELATED [] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0070938 ! contractile ring relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0005827 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005828 name: kinetochore microtubule namespace: cellular_component def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] synonym: "pole-to-kinetochore microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hjd, GOC:jl] subset: goslim_agr subset: goslim_aspergillus subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005831 name: steroid hormone aporeceptor complex namespace: cellular_component def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005832 name: chaperonin-containing T-complex namespace: cellular_component def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] synonym: "CCT particle" EXACT [] synonym: "TriC" EXACT [] is_a: GO:0044445 ! cytosolic part is_a: GO:0101031 ! chaperone complex [Term] id: GO:0005833 name: hemoglobin complex namespace: cellular_component def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732] synonym: "haemoglobin complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005834 name: heterotrimeric G-protein complex namespace: cellular_component def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein." [ISBN:0198547684] comment: See also the molecular function term 'G protein-coupled receptor activity ; GO:0004930'. synonym: "heterotrimeric G-protein GTPase activity" RELATED [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] is_a: GO:0044424 ! intracellular part is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1905360 ! GTPase complex relationship: part_of GO:0031234 ! extrinsic component of cytoplasmic side of plasma membrane [Term] id: GO:0005835 name: fatty acid synthase complex namespace: cellular_component alt_id: GO:0031373 alt_id: GO:0031374 def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pde, GOC:sgd_curators, ISBN:0716746840] subset: goslim_pir synonym: "cytosolic FAS complex" EXACT [] synonym: "cytosolic fatty acid synthase complex" EXACT [] synonym: "cytosolic type I FAS complex" EXACT [] synonym: "cytosolic type I fatty acid synthase complex" EXACT [] synonym: "FAS complex" EXACT [] synonym: "fatty acid synthetase complex" EXACT [] synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] xref: Wikipedia:Fatty_acid_synthetase_complex is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005836 name: fatty-acyl-CoA synthase complex namespace: cellular_component def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. synonym: "fatty acyl CoA synthase complex" EXACT [GOC:curators] is_a: GO:0044445 ! cytosolic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005837 name: obsolete 26S proteasome namespace: cellular_component def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin group. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] comment: This term was made obsolete because its definition was inaccurate. synonym: "26S proteasome" EXACT [] is_obsolete: true consider: GO:0000502 [Term] id: GO:0005838 name: proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] synonym: "19S regulatory particle" NARROW [] synonym: "modulator complex" RELATED [CORUM:28] synonym: "PA700 proteasome activator" NARROW [] synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0005839 name: proteasome core complex namespace: cellular_component alt_id: GO:0000503 def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] subset: goslim_metagenomics synonym: "20S core complex" NARROW [] synonym: "20S proteasome" NARROW [GOC:cjk] synonym: "macropain" EXACT [] synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0005840 name: ribosome namespace: cellular_component alt_id: GO:0033279 def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "free ribosome" NARROW [NIF_Subcellular:sao1139385046] synonym: "membrane bound ribosome" NARROW [NIF_Subcellular:sao1291545653] synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005844 name: polysome namespace: cellular_component def: "A multiribosomal structure representing a linear array of ribosomes held together by messenger RNA. They represent the active complexes in cellular protein synthesis and are able to incorporate amino acids into polypeptides both in vivo and in vitro." [ISBN:0198506732, NIF_Subcellular:sao1038025871] subset: goslim_pir synonym: "polyribosome" EXACT [NIF_Subcellular:sao1038025871] xref: NIF_Subcellular:sao1038025871 xref: Wikipedia:Polysome is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0005845 name: mRNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] synonym: "mRNA cap complex" RELATED [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005846 name: nuclear cap binding complex namespace: cellular_component def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] comment: Note that this complex can be found in the cytoplasm as well as the nucleus. synonym: "CBC" RELATED [] synonym: "mRNA cap binding complex" NARROW [] synonym: "NCBP-NIP1 complex" NARROW [] synonym: "snRNA cap binding complex" NARROW [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005847 name: mRNA cleavage and polyadenylation specificity factor complex namespace: cellular_component def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] synonym: "CFII complex" RELATED [] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "CPF complex" NARROW [] synonym: "CPSF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005848 name: mRNA cleavage stimulating factor complex namespace: cellular_component def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "CstF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005849 name: mRNA cleavage factor complex namespace: cellular_component def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005850 name: eukaryotic translation initiation factor 2 complex namespace: cellular_component def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] synonym: "eIF-2" EXACT [] synonym: "eIF2" EXACT [GOC:mah] xref: Wikipedia:EIF-2 is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005851 name: eukaryotic translation initiation factor 2B complex namespace: cellular_component def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] synonym: "eIF-2B" EXACT [] synonym: "eif2B" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005852 name: eukaryotic translation initiation factor 3 complex namespace: cellular_component def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] synonym: "eIF-3" EXACT [] synonym: "eIF3" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005853 name: eukaryotic translation elongation factor 1 complex namespace: cellular_component def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005854 name: nascent polypeptide-associated complex namespace: cellular_component def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] synonym: "NAC" EXACT [] synonym: "NACA" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005858 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion." [GOC:cilia, GOC:hla, GOC:krc, ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0005859 name: muscle myosin complex namespace: cellular_component def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] is_a: GO:0016460 ! myosin II complex is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0005861 name: troponin complex namespace: cellular_component def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005862 name: muscle thin filament tropomyosin namespace: cellular_component def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005863 name: striated muscle myosin thick filament namespace: cellular_component def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0005859 ! muscle myosin complex is_a: GO:0032982 ! myosin filament is_a: GO:0036379 ! myofilament relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005865 name: striated muscle thin filament namespace: cellular_component def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] is_a: GO:0036379 ! myofilament is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005868 name: cytoplasmic dynein complex namespace: cellular_component def: "Any dynein complex with a homodimeric dynein heavy chain core that catalyzes movement along a microtubule. Cytoplasmic dynein complexes participate in many cytoplasmic transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Some complexes participate in intraflagellar transport. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes, and may include light chains and light intermediate chains." [GOC:cilia, GOC:hla, GOC:krc, GOC:mah, PMID:12600311] comment: Note that this term is labelled based on phylogenetic classification and community usage, rather than strict cellular localization. Cytoplasmic dynein complexes may contain ciliary dyneins; therefore the term is not linked to 'cytoplasm'. Cytoplasmic dynein complexes do not contain axonemal dyneins; see GO:0005858 axonemal dynein complex. synonym: "cytoplasmic dynein heavy chain" NARROW [] synonym: "cytoplasmic dynein intermediate chain" NARROW [] synonym: "cytoplasmic dynein intermediate light chain" NARROW [] synonym: "cytoplasmic dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex [Term] id: GO:0005869 name: dynactin complex namespace: cellular_component def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732] is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005870 name: actin capping protein of dynactin complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499] is_a: GO:0008290 ! F-actin capping protein complex relationship: part_of GO:0005869 ! dynactin complex [Term] id: GO:0005871 name: kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0005872 name: minus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005873 name: plus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] subset: goslim_metagenomics synonym: "microtubuli" EXACT [] synonym: "microtubulus" EXACT [] synonym: "neurotubule" NARROW [NIF_Subcellular:sao248349196] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005875 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005876 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] is_a: GO:0005874 ! microtubule relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules." [GOC:cilia, ISBN:0815316194] is_a: GO:0005881 ! cytoplasmic microtubule is_a: GO:0044447 ! axoneme part [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule is_a: GO:0044428 ! nuclear part [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005882 name: intermediate filament namespace: cellular_component def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: FMA:63851 xref: NIF_Subcellular:sao952483289 xref: Wikipedia:Intermediate_filament is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0045111 ! intermediate filament cytoskeleton [Term] id: GO:0005883 name: neurofilament namespace: cellular_component def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732, ISBN:0716731363, ISBN:0815316194] synonym: "type IV intermediate filament" EXACT [] xref: NIF_Subcellular:sao1316272517 xref: Wikipedia:Neurofilament is_a: GO:0005882 ! intermediate filament is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732, PMID:10666339] synonym: "microfilament" EXACT [] xref: FMA:63850 xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0099513 ! polymeric cytoskeletal fiber relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005885 name: Arp2/3 protein complex namespace: cellular_component def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_plant subset: goslim_yeast synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cellular membrane" EXACT [NIF_Subcellular:sao6433132645] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005887 name: integral component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] synonym: "integral to plasma membrane" NARROW [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031226 ! intrinsic component of plasma membrane [Term] id: GO:0005888 name: obsolete proteoglycan integral to plasma membrane namespace: cellular_component def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. synonym: "proteoglycan integral to plasma membrane" EXACT [] is_obsolete: true replaced_by: GO:0005887 [Term] id: GO:0005889 name: potassium:proton exchanging ATPase complex namespace: cellular_component def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] synonym: "hydrogen:potassium-exchanging ATPase complex" EXACT [] synonym: "proton pump" BROAD [] is_a: GO:0090533 ! cation-transporting ATPase complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005890 name: sodium:potassium-exchanging ATPase complex namespace: cellular_component def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] is_a: GO:0090533 ! cation-transporting ATPase complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005891 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0005892 name: acetylcholine-gated channel complex namespace: cellular_component def: "A homo- or hetero-pentameric protein complex that forms a transmembrane channel through which ions may pass in response to acetylcholine binding." [GOC:bf, GOC:mah, PMID:12381728, PMID:15579462] synonym: "nicotinic acetylcholine receptor" BROAD [] synonym: "nicotinic acetylcholine-gated receptor-channel complex" EXACT [GOC:bf] is_a: GO:0034702 ! ion channel complex is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005893 name: interleukin-2 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] synonym: "IL-2 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005894 name: interleukin-3 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] synonym: "IL-3 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005895 name: interleukin-5 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] synonym: "IL-5 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005896 name: interleukin-6 receptor complex namespace: cellular_component def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] synonym: "IL-6 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005897 name: interleukin-9 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] synonym: "IL-9 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005898 name: interleukin-13 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879] synonym: "IL-13 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005899 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732] is_a: GO:0098802 ! plasma membrane receptor complex is_a: GO:1902911 ! protein kinase complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005900 name: oncostatin-M receptor complex namespace: cellular_component def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0005901 name: caveola namespace: cellular_component alt_id: GO:0016599 def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include flask-shaped invaginations of the plasma membrane in adipocytes associated with caveolin proteins, and minute pits or incuppings of the cell membrane formed during pinocytosis. Caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, ISBN:0721662544, PMID:16645198] synonym: "caveolae" EXACT [] synonym: "caveolar membrane" RELATED [] xref: Wikipedia:Caveolae is_a: GO:0044853 ! plasma membrane raft [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir synonym: "microvilli" RELATED [NIF_Subcellular:sao671419673] xref: NIF_Subcellular:sao671419673 xref: Wikipedia:Microvillus is_a: GO:0098858 ! actin-based cell projection [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "The dense covering of microvilli on the apical surface of a epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0098862 ! cluster of actin-based cell projections [Term] id: GO:0005905 name: clathrin-coated pit namespace: cellular_component def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732, NIF_Subcellular:sao1969557946, PMID:10559856, PMID:17284835] synonym: "coated pit" EXACT [GOC:bf] xref: NIF_Subcellular:sao1969557946 is_a: GO:0044425 ! membrane part is_a: GO:0044464 ! cell part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005906 name: obsolete clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. synonym: "adaptin" RELATED [] synonym: "clathrin adaptor" EXACT [] is_obsolete: true replaced_by: GO:0030119 [Term] id: GO:0005907 name: obsolete HA1 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP1" RELATED [] synonym: "HA1 clathrin adaptor" EXACT [] is_obsolete: true consider: GO:0030121 [Term] id: GO:0005908 name: obsolete HA2 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP2" RELATED [] synonym: "HA2 clathrin adaptor" EXACT [] is_obsolete: true consider: GO:0030122 [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two or more cells in a multicellular organism; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] synonym: "intercellular junction" EXACT [NIF_Subcellular:sao1395777368] xref: NIF_Subcellular:sao1922892319 is_a: GO:0030054 ! cell junction [Term] id: GO:0005912 name: adherens junction namespace: cellular_component def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, ISBN:0198506732] xref: Wikipedia:Adherens_junction is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005913 name: cell-cell adherens junction namespace: cellular_component def: "An adherens junction which connects a cell to another cell." [GOC:hb] is_a: GO:0005911 ! cell-cell junction is_a: GO:0005912 ! adherens junction [Term] id: GO:0005914 name: spot adherens junction namespace: cellular_component def: "A small cell-cell adherens junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] synonym: "dense plaque" BROAD [] synonym: "punctum adherens" EXACT [] is_a: GO:0005913 ! cell-cell adherens junction [Term] id: GO:0005915 name: zonula adherens namespace: cellular_component def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] synonym: "adhesion belt" EXACT [] synonym: "belt desmosome" EXACT [] synonym: "fascia adhaerens" EXACT [] synonym: "intermediate junction" EXACT [] synonym: "zonula adhaerens" EXACT [] xref: NIF_Subcellular:sao1400623473 is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005916 name: fascia adherens namespace: cellular_component def: "A cell-cell adherens junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, PMID:11732910] xref: Wikipedia:Fascia_adherens is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0014704 ! intercalated disc [Term] id: GO:0005917 name: nephrocyte diaphragm namespace: cellular_component def: "A specialized cell-cell junction found between nephrocytes of the insect kidney, which is adapted for filtration of hemolymph. The insect nephrocyte is anatomically and functionally similar to the glomerular podocyte of vertebrates." [GOC:mtg_kidney_jan10, GOC:sart, PMID:18971929] synonym: "nephrocyte junction" RELATED [PMID:8314002] is_a: GO:0036056 ! filtration diaphragm [Term] id: GO:0005918 name: septate junction namespace: cellular_component def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in arthropods." [ISBN:0815332181, PMID:11700298, PMID:12612641, PMID:20795303, PMID:28636800] synonym: "septate desmosome" RELATED [] xref: NIF_Subcellular:sao427941916 is_a: GO:0070160 ! tight junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005919 name: pleated septate junction namespace: cellular_component def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] synonym: "pleated desmosome" RELATED [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005920 name: smooth septate junction namespace: cellular_component def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] synonym: "zonula continua" EXACT [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005921 name: gap junction namespace: cellular_component def: "A cell-cell junction composed of pannexins or innexins and connexins, two different families of channel-forming proteins." [GOC:mah, GOC:mtg_muscle, http://en.wikipedia.org/wiki/Gap_junction, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181, PMID:22366062] synonym: "communicating junction" EXACT [] synonym: "electrical synapse" RELATED [http:http\://en.wikipedia.org/wiki/Gap_junction] synonym: "electrotonic synapse" RELATED [NIF_Subcellular:sao1311109124] synonym: "gap junction macula" EXACT [NIF_Subcellular:sao700839054] synonym: "gap junction plaque" EXACT [NIF_Subcellular:sao700839054] synonym: "intercellular gap junction channel" RELATED [NIF_Subcellular:sao-17780464455] synonym: "macula communicans" EXACT [] synonym: "zonula communicans" EXACT [] xref: NIF_Subcellular:sao118541872 xref: Wikipedia:Gap_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0005922 name: connexin complex namespace: cellular_component def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] synonym: "connexon" EXACT [GOC:cjm] synonym: "connexon complex" RELATED [] xref: NIF_Subcellular:sao445019788 is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005921 ! gap junction [Term] id: GO:0005923 name: bicellular tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! tight junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005924 name: cell-substrate adherens junction namespace: cellular_component def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] synonym: "hemi-adherens junction" RELATED [] is_a: GO:0005912 ! adherens junction is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0005925 name: focal adhesion namespace: cellular_component alt_id: GO:0008357 def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] synonym: "adhesion plaque" RELATED [PMID:3332661] synonym: "focal contact" EXACT [] synonym: "hemi-adherens junction" RELATED [] xref: Wikipedia:Focal_adhesion is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005926 name: connecting hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005927 name: muscle tendon junction namespace: cellular_component def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005928 name: apical hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah] synonym: "apical dense plaque" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005929 name: cilium namespace: cellular_component alt_id: GO:0072372 def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface and of some cytoplasmic parts. Each cilium is largely bounded by an extrusion of the cytoplasmic (plasma) membrane, and contains a regular longitudinal array of microtubules, anchored to a basal body." [GOC:cilia, GOC:curators, GOC:kmv, GOC:vw, ISBN:0198547684, PMID:16824949, PMID:17009929, PMID:20144998] comment: Note that we deem cilium and microtubule-based flagellum to be equivalent. In most eukaryotic species, intracellular sub-components of the cilium, such as the ciliary base and rootlet, are located near the plasma membrane. In Diplomonads such as Giardia, instead, the same ciliary parts are located further intracellularly. Also, 'cilium' may be used when axonemal structure and/or motility are unknown, or when axonemal structure is unusual. For all other cases, please refer to children of 'cilium'. Finally, note that any role of ciliary proteins in sensory events should be captured by annotating to relevant biological process terms. subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "eukaryotic flagellum" EXACT [] synonym: "flagellum" RELATED [] synonym: "microtubule-based flagellum" EXACT [] synonym: "primary cilium" NARROW [] xref: FMA:67181 xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0043226 ! organelle is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0005930 name: axoneme namespace: cellular_component alt_id: GO:0035085 alt_id: GO:0035086 def: "The bundle of microtubules and associated proteins that forms the core of cilia (also called flagella) in eukaryotic cells and is responsible for their movements." [GOC:bf, GOC:cilia, ISBN:0198547684] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In diplomonad species, such as Giardia, the axoneme may extend intracellularly up to 5um away from the plane of the plasma membrane. subset: goslim_pir synonym: "ciliary axoneme" EXACT [] synonym: "cilium axoneme" EXACT [] synonym: "flagellar axoneme" EXACT [] synonym: "flagellum axoneme" EXACT [] xref: Wikipedia:Axoneme is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044441 ! ciliary part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0097014 ! ciliary plasm [Term] id: GO:0005931 name: axonemal nexin link namespace: cellular_component def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [GOC:cilia, GOC:krc, ISBN:0198506732, PMID:21586547, PMID:21728999, PMID:22683354, PMID:9295136] synonym: "axonemal interdoublet link" EXACT [] synonym: "nexin complex" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0005933 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part [Term] id: GO:0005934 name: cellular bud tip namespace: cellular_component def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005935 name: cellular bud neck namespace: cellular_component def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005936 name: obsolete shmoo namespace: cellular_component def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. synonym: "shmoo" EXACT [] is_obsolete: true consider: GO:0001400 consider: GO:0005937 [Term] id: GO:0005937 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0099568 ! cytoplasmic region relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0005940 name: septin ring namespace: cellular_component alt_id: GO:0030481 def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] xref: Wikipedia:Septin_ring is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part [Term] id: GO:0005941 name: obsolete unlocalized protein complex namespace: cellular_component def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. synonym: "unlocalized protein complex" EXACT [] is_obsolete: true [Term] id: GO:0005942 name: phosphatidylinositol 3-kinase complex namespace: cellular_component def: "A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too." [GOC:bf, PMID:24587488] comment: For discussion of membrane association, please see https://sourceforge.net/p/geneontology/ontology-requests/11559/ subset: goslim_pir synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] synonym: "phosphoinositide 3-kinase complex" EXACT [GOC:curators] synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575] synonym: "PI3K complex" EXACT [] synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429] synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439] is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0019898 ! extrinsic component of membrane [Term] id: GO:0005943 name: phosphatidylinositol 3-kinase complex, class IA namespace: cellular_component alt_id: GO:0035030 def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex" EXACT [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] synonym: "class IA PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I [Term] id: GO:0005944 name: phosphatidylinositol 3-kinase complex, class IB namespace: cellular_component alt_id: GO:0035031 def: "A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IB phosphoinositide 3-kinase (PI3K) subunit and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex" EXACT [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] synonym: "class IB PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] is_a: GO:0097651 ! phosphatidylinositol 3-kinase complex, class I [Term] id: GO:0005945 name: 6-phosphofructokinase complex namespace: cellular_component def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732] is_a: GO:0044445 ! cytosolic part is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0005946 name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) namespace: cellular_component def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. synonym: "trehalose-6-phosphate synthase complex" EXACT [] synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005947 name: mitochondrial alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex [Term] id: GO:0005948 name: acetolactate synthase complex namespace: cellular_component def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. synonym: "acetohydroxyacid synthase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005949 name: obsolete aminoadipate-semialdehyde dehydrogenase complex namespace: cellular_component def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. synonym: "aminoadipate-semialdehyde dehydrogenase complex" EXACT [] is_obsolete: true [Term] id: GO:0005950 name: anthranilate synthase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0005951 name: carbamoyl-phosphate synthase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia group cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] synonym: "carbamoyl phosphate synthase complex" EXACT [] synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0005952 name: cAMP-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732] synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] synonym: "PKA" RELATED [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005953 name: CAAX-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874] is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005954 name: calcium- and calmodulin-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] synonym: "CAMK2" EXACT [] synonym: "CaMKII" RELATED [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005955 name: calcineurin complex namespace: cellular_component def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] synonym: "protein phosphatase type 2B complex" EXACT [] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005956 name: protein kinase CK2 complex namespace: cellular_component def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. synonym: "casein kinase II complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005957 name: obsolete debranching enzyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. synonym: "debranching enzyme" EXACT [] is_obsolete: true consider: GO:0043033 [Term] id: GO:0005958 name: DNA-dependent protein kinase-DNA ligase 4 complex namespace: cellular_component alt_id: GO:0005959 def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] is_a: GO:0044428 ! nuclear part is_a: GO:0070419 ! nonhomologous end joining complex [Term] id: GO:0005960 name: glycine cleavage complex namespace: cellular_component alt_id: GO:0005961 alt_id: GO:0070015 def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] subset: goslim_pir synonym: "glycine cleavage system" EXACT [] synonym: "glycine decarboxylase complex" EXACT [] synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] xref: Wikipedia:Glycine_decarboxylase_complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0005962 name: mitochondrial isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) [Term] id: GO:0005963 name: magnesium-dependent protein serine/threonine phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005964 name: phosphorylase kinase complex namespace: cellular_component def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0005965 name: protein farnesyltransferase complex namespace: cellular_component def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005966 name: cyclic-nucleotide phosphodiesterase complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] is_a: GO:0044464 ! cell part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0005967 name: mitochondrial pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309, ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD [] is_a: GO:0045254 ! pyruvate dehydrogenase complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005968 name: Rab-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl group from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217] synonym: "GGTase-II complex" EXACT [] synonym: "Rab geranylgeranyltransferase complex" EXACT [] synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] synonym: "RabGGTase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005969 name: serine-pyruvate aminotransferase complex namespace: cellular_component alt_id: GO:0005970 def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0005971 name: ribonucleoside-diphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate from ribonucleoside diphosphate, using either thioredoxin disulfide or glutaredoxin disulfide as an acceptor." [BRENDA:1.17.4.1] synonym: "ribonucleotide reductase complex" EXACT [GOC:mah] synonym: "RNR complex" EXACT [GOC:mah] is_a: GO:0044445 ! cytosolic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0005972 name: obsolete fibrinogen alpha chain namespace: cellular_component alt_id: GO:0008005 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen alpha chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005973 name: obsolete fibrinogen beta chain namespace: cellular_component alt_id: GO:0008006 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen beta chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005974 name: obsolete fibrinogen gamma chain namespace: cellular_component alt_id: GO:0008007 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "fibrinogen gamma chain" EXACT [] is_obsolete: true consider: GO:0005577 [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process alt_id: GO:0044261 alt_id: GO:0044723 def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate metabolic process" NARROW [] synonym: "single-organism carbohydrate metabolic process" RELATED [] xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process alt_id: GO:0044263 def: "The chemical reactions and pathways involving a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, ISBN:0198547684] subset: goslim_pir synonym: "glycan metabolic process" NARROW [] synonym: "glycan metabolism" NARROW [] synonym: "multicellular organismal polysaccharide metabolic process" NARROW [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha-(1->4) glycosidic linkage, joined together by alpha-(1->6) glycosidic linkages." [ISBN:0198506732] synonym: "glycogen metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0006112 ! energy reserve metabolic process [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:GLYCOGENSYNTH-PWY is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732] synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] synonym: "glycogenolysis" EXACT [GOC:sl] xref: MetaCyc:GLYCOCAT-PWY is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] synonym: "regulation of glycogenolysis" EXACT [GOC:sl] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process relationship: regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0005982 name: starch metabolic process namespace: biological_process def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732] synonym: "starch metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0005983 name: starch catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch breakdown" EXACT [] synonym: "starch catabolism" EXACT [] synonym: "starch degradation" EXACT [] xref: MetaCyc:PWY-842 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005984 name: disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X] synonym: "disaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005985 name: sucrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005986 name: sucrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose anabolism" EXACT [] synonym: "sucrose biosynthesis" EXACT [] synonym: "sucrose formation" EXACT [] synonym: "sucrose synthesis" EXACT [] xref: MetaCyc:SUCSYN-PWY is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005987 name: sucrose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] synonym: "sucrose breakdown" EXACT [] synonym: "sucrose catabolism" EXACT [] synonym: "sucrose degradation" EXACT [] is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005988 name: lactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005989 name: lactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose anabolism" EXACT [] synonym: "lactose biosynthesis" EXACT [] synonym: "lactose formation" EXACT [] synonym: "lactose synthesis" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005990 name: lactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] synonym: "lactose breakdown" EXACT [] synonym: "lactose catabolism" EXACT [] synonym: "lactose degradation" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005991 name: trehalose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose metabolic process" EXACT [] synonym: "mycose metabolism" EXACT [] synonym: "mykose metabolic process" EXACT [] synonym: "mykose metabolism" EXACT [] synonym: "trehalose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005992 name: trehalose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose biosynthesis" EXACT [] synonym: "mycose biosynthetic process" EXACT [] synonym: "mykose biosynthesis" EXACT [] synonym: "mykose biosynthetic process" EXACT [] synonym: "trehalose anabolism" EXACT [] synonym: "trehalose biosynthesis" EXACT [] synonym: "trehalose formation" EXACT [] synonym: "trehalose synthesis" EXACT [] xref: MetaCyc:PWY-881 xref: MetaCyc:TREHALOSESYN-PWY xref: MetaCyc:TRESYN-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005993 name: trehalose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] synonym: "mycose catabolic process" EXACT [] synonym: "mycose catabolism" EXACT [] synonym: "mykose catabolic process" EXACT [] synonym: "mykose catabolism" EXACT [] synonym: "trehalose breakdown" EXACT [] synonym: "trehalose catabolism" EXACT [] synonym: "trehalose degradation" EXACT [] xref: MetaCyc:TREDEGLOW-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005994 name: melibiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] synonym: "melibiose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005995 name: melibiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] synonym: "melibiose breakdown" EXACT [] synonym: "melibiose catabolism" EXACT [] synonym: "melibiose degradation" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732] synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0005997 name: xylulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0005998 name: xylulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose breakdown" EXACT [] synonym: "xylulose catabolism" EXACT [] synonym: "xylulose degradation" EXACT [] xref: MetaCyc:XYLCAT-PWY is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0005999 name: xylulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] synonym: "xylulose anabolism" EXACT [] synonym: "xylulose biosynthesis" EXACT [] synonym: "xylulose formation" EXACT [] synonym: "xylulose synthesis" EXACT [] is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0006000 name: fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732] synonym: "fructose metabolism" EXACT [] xref: Wikipedia:Fructose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006001 name: fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] synonym: "fructose breakdown" EXACT [] synonym: "fructose catabolism" EXACT [] synonym: "fructose degradation" EXACT [] is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006002 name: fructose 6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732] synonym: "fructose 6-phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006003 name: fructose 2,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732] synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006004 name: fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732] synonym: "fucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006005 name: L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] synonym: "L-fucose anabolism" EXACT [] synonym: "L-fucose biosynthesis" EXACT [] synonym: "L-fucose formation" EXACT [] synonym: "L-fucose synthesis" EXACT [] is_a: GO:0042353 ! fucose biosynthetic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732] synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006009 name: glucose 1-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] is_a: GO:0016310 ! phosphorylation is_a: GO:0019255 ! glucose 1-phosphate metabolic process [Term] id: GO:0006011 name: UDP-glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucose metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006012 name: galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732] synonym: "galactose metabolism" EXACT [] xref: Wikipedia:Galactose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006013 name: mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732] synonym: "mannose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006014 name: D-ribose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732] synonym: "D-ribose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0006015 name: 5-phosphoribose 1-diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] synonym: "PRPP biosynthetic process" EXACT [] xref: MetaCyc:PWY0-661 is_a: GO:0046390 ! ribose phosphate biosynthetic process is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process [Term] id: GO:0006016 name: 2-deoxyribose 1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732] synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] synonym: "2-deoxyribose 1-phosphate formation" EXACT [] synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0006017 name: deoxyribose 1,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process [Term] id: GO:0006018 name: 2-deoxyribose 1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] synonym: "2-deoxyribose 1-phosphate breakdown" EXACT [] synonym: "2-deoxyribose 1-phosphate catabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate degradation" EXACT [] synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0006019 name: deoxyribose 5-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] is_a: GO:0016310 ! phosphorylation is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process [Term] id: GO:0006020 name: inositol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684] synonym: "inositol metabolism" EXACT [] synonym: "myo-inositol metabolic process" NARROW [] synonym: "myo-inositol metabolism" NARROW [] synonym: "vitamin Bh metabolic process" EXACT [] synonym: "vitamin Bh metabolism" EXACT [] xref: Wikipedia:Inositol is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0006021 name: inositol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, ISBN:0198547684] synonym: "inositol anabolism" EXACT [] synonym: "inositol biosynthesis" EXACT [] synonym: "inositol formation" EXACT [] synonym: "inositol synthesis" EXACT [] synonym: "myo-inositol biosynthesis" NARROW [] synonym: "myo-inositol biosynthetic process" NARROW [] synonym: "vitamin Bh biosynthesis" EXACT [] synonym: "vitamin Bh biosynthetic process" EXACT [] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006025 name: galactosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] synonym: "galactosaminoglycan anabolism" EXACT [] synonym: "galactosaminoglycan biosynthesis" EXACT [] synonym: "galactosaminoglycan formation" EXACT [] synonym: "galactosaminoglycan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732] synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006028 name: galactosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] synonym: "galactosaminoglycan breakdown" EXACT [] synonym: "galactosaminoglycan catabolism" EXACT [] synonym: "galactosaminoglycan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006029 name: proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan metabolism" EXACT [] synonym: "proteoglycan sulfate transfer" NARROW [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006030 name: chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] synonym: "chitin metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006031 name: chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] synonym: "chitin anabolism" EXACT [] synonym: "chitin biosynthesis" EXACT [] synonym: "chitin formation" EXACT [] synonym: "chitin synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0006030 ! chitin metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006032 name: chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] synonym: "chitin breakdown" EXACT [] synonym: "chitin catabolism" EXACT [] synonym: "chitin degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0006030 ! chitin metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process in which chitin is transported to, or maintained in, a specific location." [GOC:ai] synonym: "chitin localisation" EXACT [GOC:mah] synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006034 name: cuticle chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006035 name: cuticle chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin anabolism" EXACT [] synonym: "cuticle chitin biosynthesis" EXACT [] synonym: "cuticle chitin formation" EXACT [] synonym: "cuticle chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006034 ! cuticle chitin metabolic process relationship: part_of GO:0040003 ! chitin-based cuticle development [Term] id: GO:0006036 name: cuticle chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin breakdown" EXACT [] synonym: "cuticle chitin catabolism" EXACT [] synonym: "cuticle chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006034 ! cuticle chitin metabolic process [Term] id: GO:0006037 name: cell wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process relationship: part_of GO:0071554 ! cell wall organization or biogenesis [Term] id: GO:0006038 name: cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin anabolism" EXACT [] synonym: "cell wall chitin biosynthesis" EXACT [] synonym: "cell wall chitin formation" EXACT [] synonym: "cell wall chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006037 ! cell wall chitin metabolic process relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0006039 name: cell wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin breakdown" EXACT [] synonym: "cell wall chitin catabolism" EXACT [] synonym: "cell wall chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006037 ! cell wall chitin metabolic process [Term] id: GO:0006040 name: amino sugar metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "amino sugar metabolism" EXACT [] synonym: "aminosaccharide metabolic process" EXACT [] synonym: "aminosaccharide metabolism" EXACT [] is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0006041 name: glucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine metabolic process" EXACT [] synonym: "chitosamine metabolism" EXACT [] synonym: "glucosamine metabolism" EXACT [] is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006042 name: glucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine biosynthesis" EXACT [] synonym: "chitosamine biosynthetic process" EXACT [] synonym: "glucosamine anabolism" EXACT [] synonym: "glucosamine biosynthesis" EXACT [] synonym: "glucosamine formation" EXACT [] synonym: "glucosamine synthesis" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006043 name: glucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732] synonym: "chitosamine catabolic process" EXACT [] synonym: "chitosamine catabolism" EXACT [] synonym: "glucosamine breakdown" EXACT [] synonym: "glucosamine catabolism" EXACT [] synonym: "glucosamine degradation" EXACT [] xref: MetaCyc:GLUAMCAT-PWY is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006044 name: N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine metabolism" EXACT [] is_a: GO:1901071 ! glucosamine-containing compound metabolic process [Term] id: GO:0006045 name: N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine anabolism" EXACT [] synonym: "N-acetylglucosamine biosynthesis" EXACT [] synonym: "N-acetylglucosamine formation" EXACT [] synonym: "N-acetylglucosamine synthesis" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:1901073 ! glucosamine-containing compound biosynthetic process [Term] id: GO:0006046 name: N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [ISBN:0198506732] synonym: "N-acetylglucosamine breakdown" EXACT [] synonym: "N-acetylglucosamine catabolism" EXACT [] synonym: "N-acetylglucosamine degradation" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:1901072 ! glucosamine-containing compound catabolic process [Term] id: GO:0006047 name: UDP-N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006048 name: UDP-N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-GlcNAc biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine formation" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] xref: MetaCyc:UDPNAGSYN-PWY is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0006049 name: UDP-N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] synonym: "UDP-N-acetylglucosamine degradation" EXACT [] is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0006050 name: mannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [CHEBI:mannosamine, GOC:curators] synonym: "mannosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006051 name: N-acetylmannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine metabolism" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process [Term] id: GO:0006052 name: N-acetylmannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine anabolism" EXACT [] synonym: "N-acetylmannosamine biosynthesis" EXACT [] synonym: "N-acetylmannosamine formation" EXACT [] synonym: "N-acetylmannosamine synthesis" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046347 ! mannosamine biosynthetic process [Term] id: GO:0006053 name: N-acetylmannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732] synonym: "N-acetylmannosamine breakdown" EXACT [] synonym: "N-acetylmannosamine catabolism" EXACT [] synonym: "N-acetylmannosamine degradation" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046346 ! mannosamine catabolic process [Term] id: GO:0006054 name: N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] synonym: "N-acetylneuraminate metabolism" EXACT [] synonym: "sialic acid metabolic process" BROAD [] synonym: "sialic acid metabolism" BROAD [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006055 name: CMP-N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] synonym: "CMP-N-acetylneuraminate formation" EXACT [] synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process [Term] id: GO:0006056 name: mannoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006057 name: mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein anabolism" EXACT [] synonym: "mannoprotein biosynthesis" EXACT [] synonym: "mannoprotein formation" EXACT [] synonym: "mannoprotein synthesis" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006058 name: mannoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues." [ISBN:0198506732] synonym: "mannoprotein breakdown" EXACT [] synonym: "mannoprotein catabolism" EXACT [] synonym: "mannoprotein degradation" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006059 name: hexitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol metabolism" EXACT [] synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] synonym: "sugar alcohol (hexitol) metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006060 name: sorbitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol metabolism" EXACT [] xref: MetaCyc:P461-PWY is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0006061 name: sorbitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol anabolism" EXACT [] synonym: "sorbitol biosynthesis" EXACT [] synonym: "sorbitol formation" EXACT [] synonym: "sorbitol synthesis" EXACT [] is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0006062 name: sorbitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "sorbitol breakdown" EXACT [] synonym: "sorbitol catabolism" EXACT [] synonym: "sorbitol degradation" EXACT [] xref: MetaCyc:SORBDEG-PWY is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0006063 name: uronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732] synonym: "uronic acid metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006064 name: glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] synonym: "glucuronate breakdown" EXACT [] synonym: "glucuronate catabolism" EXACT [] synonym: "glucuronate degradation" EXACT [] is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0006065 name: UDP-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucuronate anabolism" EXACT [] synonym: "UDP-glucuronate biosynthesis" EXACT [] synonym: "UDP-glucuronate formation" EXACT [] synonym: "UDP-glucuronate synthesis" EXACT [] xref: MetaCyc:PWY-4841 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046398 ! UDP-glucuronate metabolic process [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [CHEBI:30879, ISBN:0198506732] subset: goslim_pir synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0006067 name: ethanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0006068 name: ethanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol breakdown" EXACT [] synonym: "ethanol catabolism" EXACT [] synonym: "ethanol degradation" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006069 name: ethanol oxidation namespace: biological_process def: "An ethanol metabolic process in which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006070 name: octanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] synonym: "octanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:1903173 ! fatty alcohol metabolic process [Term] id: GO:0006071 name: glycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] synonym: "glycerol metabolism" EXACT [] xref: MetaCyc:GLYCEROLMETAB-PWY is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006072 name: glycerol-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732] synonym: "glycerol-3-phosphate metabolism" EXACT [] is_a: GO:0052646 ! alditol phosphate metabolic process [Term] id: GO:0006073 name: cellular glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues, occurring at the level of an individual cell." [ISBN:0198547684] synonym: "cellular glucan metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0006074 name: (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [ISBN:0198506732] synonym: "1,3-beta-D-glucan metabolic process" BROAD [GOC:tb] synonym: "1,3-beta-D-glucan metabolism" EXACT [] synonym: "1,3-beta-glucan metabolic process" BROAD [GOC:tb] synonym: "beta-1,3 glucan metabolic process" EXACT [] synonym: "beta-1,3 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006075 name: (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds." [GOC:ai] synonym: "1,3-beta-D-glucan biosynthetic process" EXACT [] synonym: "1,3-beta-glucan anabolism" EXACT [] synonym: "1,3-beta-glucan biosynthesis" EXACT [] synonym: "1,3-beta-glucan formation" EXACT [] synonym: "1,3-beta-glucan synthesis" EXACT [] synonym: "beta-1,3 glucan anabolism" EXACT [] synonym: "beta-1,3 glucan biosynthesis" EXACT [] synonym: "beta-1,3 glucan biosynthetic process" EXACT [] synonym: "beta-1,3 glucan formation" EXACT [] synonym: "beta-1,3 glucan synthesis" EXACT [] is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006076 name: (1->3)-beta-D-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (1->3)-beta-D-glucans." [GOC:ai] synonym: "1,3-beta-D-glucan catabolic process" EXACT [] synonym: "1,3-beta-glucan breakdown" EXACT [] synonym: "1,3-beta-glucan catabolism" EXACT [] synonym: "1,3-beta-glucan degradation" EXACT [] synonym: "beta-1,3 glucan breakdown" EXACT [] synonym: "beta-1,3 glucan catabolic process" EXACT [] synonym: "beta-1,3 glucan catabolism" EXACT [] synonym: "beta-1,3 glucan degradation" EXACT [] is_a: GO:0006074 ! (1->3)-beta-D-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006077 name: (1->6)-beta-D-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (1->6)-beta-D-glucans, compounds composed of glucose residues linked by (1->6)-beta-D-glucosidic bonds." [ISBN:0198506732] synonym: "1,6-beta-glucan metabolic process" EXACT [] synonym: "1,6-beta-glucan metabolism" EXACT [] synonym: "beta-1,6 glucan metabolic process" EXACT [] synonym: "beta-1,6 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006078 name: (1->6)-beta-D-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of (1->6)-beta-D-glucans." [GOC:ai] synonym: "1,6-beta-glucan anabolism" EXACT [] synonym: "1,6-beta-glucan biosynthesis" EXACT [] synonym: "1,6-beta-glucan biosynthetic process" EXACT [] synonym: "1,6-beta-glucan formation" EXACT [] synonym: "1,6-beta-glucan synthesis" EXACT [] synonym: "beta-1,6 glucan anabolism" EXACT [] synonym: "beta-1,6 glucan biosynthesis" EXACT [] synonym: "beta-1,6 glucan biosynthetic process" EXACT [] synonym: "beta-1,6 glucan formation" EXACT [] synonym: "beta-1,6 glucan synthesis" EXACT [] is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006079 name: (1->6)-beta-D-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (1->6)-beta-D-glucans." [GOC:ai] synonym: "1,6-beta-D-glucan breakdown" EXACT [] synonym: "1,6-beta-D-glucan catabolic process" EXACT [] synonym: "1,6-beta-D-glucan catabolism" EXACT [] synonym: "1,6-beta-D-glucan degradation" EXACT [] synonym: "beta-1,6 glucan breakdown" EXACT [] synonym: "beta-1,6 glucan catabolic process" EXACT [] synonym: "beta-1,6 glucan catabolism" EXACT [] synonym: "beta-1,6 glucan degradation" EXACT [] is_a: GO:0006077 ! (1->6)-beta-D-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006080 name: substituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] synonym: "substituted mannan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0006081 name: cellular aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732] subset: goslim_pir synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] subset: goslim_pir synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006083 name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006084 name: acetyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] synonym: "acetyl coenzyme A metabolic process" EXACT [] synonym: "acetyl coenzyme A metabolism" EXACT [] synonym: "acetyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0006085 name: acetyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] synonym: "acetyl-CoA anabolism" EXACT [] synonym: "acetyl-CoA biosynthesis" EXACT [] synonym: "acetyl-CoA formation" EXACT [] synonym: "acetyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY-5173 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0006086 name: acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] synonym: "acetyl-CoA formation from pyruvate" EXACT [] synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] synonym: "pyruvate dehydrogenase pathway" EXACT [] xref: MetaCyc:PYRUVDEHYD-PWY is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0006088 name: obsolete acetate to acetyl-CoA namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "acetate to acetyl-CoA" EXACT [] is_obsolete: true consider: GO:0003987 [Term] id: GO:0006089 name: lactate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] synonym: "2-hydroxypropanoate metabolic process" EXACT [] synonym: "2-hydroxypropanoate metabolism" EXACT [] synonym: "alpha-hydroxypropionate metabolic process" EXACT [] synonym: "alpha-hydroxypropionate metabolism" EXACT [] synonym: "lactate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0006090 name: pyruvate metabolic process namespace: biological_process alt_id: GO:0006087 def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] synonym: "pyruvate dehydrogenase bypass" RELATED [] synonym: "pyruvate metabolism" EXACT [] xref: MetaCyc:P41-PWY xref: Wikipedia:Pyruvic_acid is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [MetaCyc:GLUCONEO-PWY] synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0006096 name: glycolytic process namespace: biological_process alt_id: GO:0019641 alt_id: GO:0019642 def: "The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules." [GOC:bf, GOC:dph, ISBN:0201090910, ISBN:0716720094, ISBN:0879010479, Wikipedia:Glycolysis] synonym: "anaerobic glycolysis" RELATED [] synonym: "Embden-Meyerhof pathway" RELATED [] synonym: "Embden-Meyerhof-Parnas pathway" RELATED [] synonym: "glycolysis" RELATED [GOC:dph] synonym: "modifed Embden-Meyerhof pathway" RELATED [] xref: MetaCyc:GLYCOLYSIS-VARIANTS is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006757 ! ATP generation from ADP is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0006097 name: glyoxylate cycle namespace: biological_process def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732] synonym: "glyoxylate bypass" EXACT [] xref: MetaCyc:GLYOXYLATE-BYPASS xref: Wikipedia:Glyoxylate_cycle is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0046487 ! glyoxylate metabolic process [Term] id: GO:0006098 name: pentose-phosphate shunt namespace: biological_process def: "The glucose-6-phosphate catabolic process in which, coupled to NADPH synthesis, glucose-6-P is oxidized with the formation of carbon dioxide (CO2) and ribulose 5-phosphate; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732, MetaCyc:PENTOSE-P-PWY] synonym: "hexose monophosphate pathway" EXACT [] synonym: "pentose phosphate pathway" EXACT [] synonym: "pentose phosphate shunt" EXACT [] synonym: "pentose-phosphate pathway" EXACT [] xref: KEGG_PATHWAY:00030 xref: MetaCyc:PENTOSE-P-PWY xref: Reactome:R-HSA-71336 "Pentose phosphate pathway (hexose monophosphate shunt), Homo sapiens" xref: Wikipedia:Pentose_phosphate_pathway is_a: GO:0006740 ! NADPH regeneration is_a: GO:0051156 ! glucose 6-phosphate metabolic process [Term] id: GO:0006099 name: tricarboxylic acid cycle namespace: biological_process def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732] synonym: "citric acid cycle" EXACT [] synonym: "Krebs cycle" EXACT [] synonym: "TCA cycle" EXACT [] xref: MetaCyc:P105-PWY xref: MetaCyc:P42-PWY xref: MetaCyc:TCA xref: Wikipedia:Tricarboxylic_acid_cycle is_a: GO:0044238 ! primary metabolic process relationship: part_of GO:0009060 ! aerobic respiration [Term] id: GO:0006100 name: obsolete tricarboxylic acid cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "citric acid cycle intermediate metabolic process" EXACT [] synonym: "citric acid cycle intermediate metabolism" EXACT [] synonym: "Krebs cycle intermediate metabolic process" EXACT [] synonym: "Krebs cycle intermediate metabolism" EXACT [] synonym: "TCA intermediate metabolic process" EXACT [] synonym: "TCA intermediate metabolism" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolic process" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] is_obsolete: true consider: GO:0006099 consider: GO:0006101 consider: GO:0006103 consider: GO:0006104 consider: GO:0006105 consider: GO:0006106 consider: GO:0006107 consider: GO:0006108 [Term] id: GO:0006101 name: citrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] synonym: "citrate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process [Term] id: GO:0006102 name: isocitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732] synonym: "isocitrate metabolism" EXACT [] is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0006103 name: 2-oxoglutarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732] synonym: "2-ketoglutarate metabolic process" EXACT [] synonym: "2-ketoglutarate metabolism" EXACT [] synonym: "2-oxoglutarate metabolism" EXACT [] synonym: "alpha-ketoglutarate metabolic process" EXACT [] synonym: "alpha-ketoglutarate metabolism" EXACT [] synonym: "alpha-oxoglutarate metabolic process" EXACT [] synonym: "alpha-oxoglutarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006104 name: succinyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] synonym: "succinyl-CoA metabolism" EXACT [] is_a: GO:0006637 ! acyl-CoA metabolic process [Term] id: GO:0006105 name: succinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732] synonym: "succinate metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006106 name: fumarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732] synonym: "fumarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006107 name: oxaloacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732] synonym: "oxaloacetate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006108 name: malate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732] synonym: "malate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006110 name: regulation of glycolytic process namespace: biological_process alt_id: GO:0090525 def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] synonym: "regulation of glycolysis involved in cellular glucose homeostasis" EXACT [] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043470 ! regulation of carbohydrate catabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process is_a: GO:1903578 ! regulation of ATP metabolic process relationship: regulates GO:0006096 ! glycolytic process [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process alt_id: GO:0090526 def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] synonym: "regulation of gluconeogenesis involved in cellular glucose homeostasis" RELATED [] synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir synonym: "energy reserve metabolism" EXACT [] is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006113 name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, coupling the oxidation and reduction of NAD/H and the generation of adenosine triphosphate (ATP)." [GOC:curators, ISBN:0201090910, ISBN:124925502, MetaCyc:Fermentation] subset: goslim_pir xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006114 name: glycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732] synonym: "glycerol anabolism" EXACT [] synonym: "glycerol biosynthesis" EXACT [] synonym: "glycerol formation" EXACT [] synonym: "glycerol synthesis" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019401 ! alditol biosynthetic process [Term] id: GO:0006115 name: ethanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732] synonym: "ethanol anabolism" EXACT [] synonym: "ethanol biosynthesis" EXACT [] synonym: "ethanol formation" EXACT [] synonym: "ethanol synthesis" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006116 name: NADH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] synonym: "NAD (reduced) dehydrogenation" EXACT [] synonym: "NAD (reduced) oxidation" EXACT [] synonym: "NADH dehydrogenation" EXACT [] synonym: "reduced NAD dehydrogenation" EXACT [] synonym: "reduced NAD oxidation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019674 ! NAD metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006117 name: acetaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [CHEBI:15343, GOC:go_curators] synonym: "acetaldehyde metabolism" EXACT [] synonym: "ethanal metabolic process" EXACT [] synonym: "ethanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0006118 name: obsolete electron transport namespace: biological_process def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [GOC:curators] comment: This term was made obsolete because it describes a molecular function. synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "electron transport" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] is_obsolete: true replaced_by: GO:0055114 consider: GO:0016491 consider: GO:0022904 [Term] id: GO:0006119 name: oxidative phosphorylation namespace: biological_process def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732, ISBN:0471331309] subset: goslim_pir synonym: "respiratory-chain phosphorylation" EXACT [] xref: Wikipedia:Oxidative_phosphorylation is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0016310 ! phosphorylation is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006121 name: mitochondrial electron transport, succinate to ubiquinone namespace: biological_process def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] synonym: "complex II (succinate to ubiquinone)" RELATED [] synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006122 name: mitochondrial electron transport, ubiquinol to cytochrome c namespace: biological_process def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006123 name: mitochondrial electron transport, cytochrome c to oxygen namespace: biological_process def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] synonym: "complex IV (reduction of O2)" RELATED [] is_a: GO:0019646 ! aerobic electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006124 name: ferredoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732] synonym: "ferredoxin metabolism" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006125 name: obsolete thioredoxin pathway namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is not clear what it is intended to represent. synonym: "thioredoxin pathway" EXACT [] synonym: "thioredoxin reduction" NARROW [] xref: MetaCyc:THIOREDOX-PWY is_obsolete: true consider: GO:0045454 [Term] id: GO:0006126 name: obsolete other pathways of electron transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other pathways of electron transport" EXACT [] is_obsolete: true replaced_by: GO:0022900 [Term] id: GO:0006127 name: glycerophosphate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, ISBN:071672009, PMID:16368075] xref: MetaCyc:PWY-6118 is_a: GO:0006116 ! NADH oxidation is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0006128 name: obsolete oxidized glutathione reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. synonym: "oxidized glutathione reduction" EXACT [] is_obsolete: true consider: GO:0004362 consider: GO:0006749 consider: GO:0022900 [Term] id: GO:0006129 name: obsolete protein-disulfide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "protein-disulfide reduction" EXACT [] synonym: "protein-disulphide reduction" EXACT [] is_obsolete: true consider: GO:0019153 consider: GO:0022900 [Term] id: GO:0006130 name: obsolete 6-phosphofructokinase reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. synonym: "6-phosphofructokinase reduction" EXACT [] is_obsolete: true consider: GO:0003872 consider: GO:0022900 [Term] id: GO:0006131 name: obsolete dihydrolipoamide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrolipoamide reduction" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0022900 consider: GO:0051068 [Term] id: GO:0006132 name: obsolete dihydrolipoylprotein reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrolipoylprotein reduction" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0022900 [Term] id: GO:0006133 name: obsolete 5,10-methylenetetrahydrofolate oxidation namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "5,10-methylenetetrahydrofolate oxidation" EXACT [] is_obsolete: true consider: GO:0004487 consider: GO:0004488 consider: GO:0004489 consider: GO:0033738 [Term] id: GO:0006134 name: obsolete dihydrobiopterin reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrobiopterin reduction" EXACT [] is_obsolete: true consider: GO:0022900 consider: GO:0047040 consider: GO:0051066 [Term] id: GO:0006135 name: obsolete dihydropteridine reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydropteridine reduction" EXACT [] is_obsolete: true consider: GO:0004155 consider: GO:0022900 consider: GO:0051067 [Term] id: GO:0006139 name: nucleobase-containing compound metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_pir subset: goslim_plant synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside and nucleotide metabolic process" RELATED [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] synonym: "regulation of nucleotide metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006141 name: regulation of purine nucleobase metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] synonym: "regulation of purine base metabolic process" EXACT [GOC:go_curators] synonym: "regulation of purine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0006144 ! purine nucleobase metabolic process [Term] id: GO:0006142 name: regulation of pyrimidine nucleobase metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidine nucleobases." [GOC:go_curators] synonym: "regulation of pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "regulation of pyrimidine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0006143 name: obsolete purine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. synonym: "purine metabolic process" EXACT [] is_obsolete: true consider: GO:0006144 consider: GO:0006163 consider: GO:0042278 [Term] id: GO:0006144 name: purine nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators] synonym: "purine base metabolic process" EXACT [GOC:go_curators] synonym: "purine base metabolism" EXACT [] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006145 name: purine nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] synonym: "purine base breakdown" EXACT [] synonym: "purine base catabolic process" EXACT [GOC:go_curators] synonym: "purine base catabolism" EXACT [] synonym: "purine base degradation" EXACT [] is_a: GO:0006144 ! purine nucleobase metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006146 name: adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732] synonym: "adenine breakdown" EXACT [] synonym: "adenine catabolism" EXACT [] synonym: "adenine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0006147 name: guanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] synonym: "guanine breakdown" EXACT [] synonym: "guanine catabolism" EXACT [] synonym: "guanine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006148 name: inosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] synonym: "inosine breakdown" EXACT [] synonym: "inosine catabolism" EXACT [] synonym: "inosine degradation" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006149 name: deoxyinosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] synonym: "deoxyinosine breakdown" EXACT [] synonym: "deoxyinosine catabolism" EXACT [] synonym: "deoxyinosine degradation" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006150 name: hypoxanthine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295] is_a: GO:0009114 ! hypoxanthine catabolic process [Term] id: GO:0006151 name: xanthine oxidation namespace: biological_process def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl] is_a: GO:0009115 ! xanthine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006152 name: purine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] synonym: "purine nucleoside breakdown" EXACT [] synonym: "purine nucleoside catabolism" EXACT [] synonym: "purine nucleoside degradation" EXACT [] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0042278 ! purine nucleoside metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006153 name: obsolete purine nucleosidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "purine nucleosidase reaction" EXACT [] is_obsolete: true replaced_by: GO:0008477 [Term] id: GO:0006154 name: adenosine catabolic process namespace: biological_process alt_id: GO:0006156 def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] synonym: "adenosine breakdown" EXACT [] synonym: "adenosine catabolism" EXACT [] synonym: "adenosine degradation" EXACT [] synonym: "adenosine phosphorolysis" RELATED [] is_a: GO:0042737 ! drug catabolic process is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006155 name: obsolete adenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "adenosine deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004000 [Term] id: GO:0006157 name: deoxyadenosine catabolic process namespace: biological_process alt_id: GO:0006159 def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyadenosine breakdown" EXACT [] synonym: "deoxyadenosine catabolism" EXACT [] synonym: "deoxyadenosine degradation" EXACT [] synonym: "deoxyadenosine phosphorolysis" RELATED [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006158 name: obsolete deoxyadenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "deoxyadenosine deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0046936 [Term] id: GO:0006161 name: deoxyguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [CHEBI:17172, GOC:jl] synonym: "deoxyguanosine breakdown" EXACT [] synonym: "deoxyguanosine catabolism" EXACT [] synonym: "deoxyguanosine degradation" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006162 name: obsolete purine/pyrimidine nucleoside diphosphate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "purine/pyrimidine nucleoside diphosphate reduction" EXACT [] is_obsolete: true consider: GO:0004748 [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072521 ! purine-containing compound metabolic process [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0046939 ! nucleotide phosphorylation [Term] id: GO:0006166 name: purine ribonucleoside salvage namespace: biological_process def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] xref: MetaCyc:P121-PWY is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0006167 name: AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732] synonym: "AMP anabolism" EXACT [] synonym: "AMP biosynthesis" EXACT [] synonym: "AMP formation" EXACT [] synonym: "AMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006168 name: adenine salvage namespace: biological_process def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine salvage pathway" EXACT [] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046084 ! adenine biosynthetic process [Term] id: GO:0006169 name: adenosine salvage namespace: biological_process def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046086 ! adenosine biosynthetic process [Term] id: GO:0006170 name: dAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732] synonym: "dAMP anabolism" EXACT [] synonym: "dAMP biosynthesis" EXACT [] synonym: "dAMP formation" EXACT [] synonym: "dAMP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0006171 name: cAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] synonym: "3',5' cAMP biosynthesis" EXACT [] synonym: "3',5' cAMP biosynthetic process" EXACT [] synonym: "3',5'-cAMP biosynthesis" EXACT [] synonym: "3',5'-cAMP biosynthetic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "cAMP anabolism" EXACT [] synonym: "cAMP biosynthesis" EXACT [] synonym: "cAMP formation" EXACT [] synonym: "cAMP synthesis" EXACT [] synonym: "cyclic AMP biosynthesis" EXACT [] synonym: "cyclic AMP biosynthetic process" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046058 ! cAMP metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process [Term] id: GO:0006172 name: ADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] synonym: "ADP anabolism" EXACT [] synonym: "ADP biosynthesis" EXACT [] synonym: "ADP formation" EXACT [] synonym: "ADP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006173 name: dADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732] synonym: "dADP anabolism" EXACT [] synonym: "dADP biosynthesis" EXACT [] synonym: "dADP formation" EXACT [] synonym: "dADP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006174 name: dADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006175 name: dATP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732] synonym: "dATP anabolism" EXACT [] synonym: "dATP biosynthesis" EXACT [] synonym: "dATP formation" EXACT [] synonym: "dATP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0006176 name: dATP biosynthetic process from ADP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732] synonym: "dATP anabolism from ADP" EXACT [] synonym: "dATP formation from ADP" EXACT [] synonym: "dATP synthesis from ADP" EXACT [] is_a: GO:0006175 ! dATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006177 name: GMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732] synonym: "GMP anabolism" EXACT [] synonym: "GMP biosynthesis" EXACT [] synonym: "GMP formation" EXACT [] synonym: "GMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046037 ! GMP metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0006178 name: guanine salvage namespace: biological_process def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine nucleobase salvage is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006179 name: guanosine salvage namespace: biological_process def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0006180 name: deoxyguanosine salvage namespace: biological_process def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043098 ! purine deoxyribonucleoside salvage [Term] id: GO:0006181 name: dGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732] synonym: "dGMP anabolism" EXACT [] synonym: "dGMP biosynthesis" EXACT [] synonym: "dGMP formation" EXACT [] synonym: "dGMP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0006182 name: cGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732] synonym: "cGMP anabolism" EXACT [] synonym: "cGMP biosynthesis" EXACT [] synonym: "cGMP formation" EXACT [] synonym: "cGMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046068 ! cGMP metabolic process is_a: GO:0052652 ! cyclic purine nucleotide metabolic process [Term] id: GO:0006183 name: GTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732] synonym: "GTP anabolism" EXACT [] synonym: "GTP biosynthesis" EXACT [] synonym: "GTP formation" EXACT [] synonym: "GTP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046039 ! GTP metabolic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0006184 name: obsolete GTP catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "GTP breakdown" EXACT [] synonym: "GTP catabolism" EXACT [] synonym: "GTP degradation" EXACT [] synonym: "GTP hydrolysis" NARROW [] is_obsolete: true consider: GO:0003924 [Term] id: GO:0006185 name: dGDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732] synonym: "dGDP anabolism" EXACT [] synonym: "dGDP biosynthesis" EXACT [] synonym: "dGDP formation" EXACT [] synonym: "dGDP synthesis" EXACT [] is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006186 name: dGDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006187 name: dGTP biosynthetic process from dGDP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732] synonym: "dGTP anabolism from dGDP" EXACT [] synonym: "dGTP formation from dGDP" EXACT [] synonym: "dGTP synthesis from dGDP" EXACT [] is_a: GO:0046066 ! dGDP metabolic process is_a: GO:0046071 ! dGTP biosynthetic process [Term] id: GO:0006188 name: IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732] synonym: "IMP anabolism" EXACT [] synonym: "IMP biosynthesis" EXACT [] synonym: "IMP formation" EXACT [] synonym: "IMP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006189 name: 'de novo' IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] synonym: "'de novo' IMP anabolism" EXACT [] synonym: "'de novo' IMP biosynthesis" EXACT [] synonym: "'de novo' IMP formation" EXACT [] synonym: "'de novo' IMP synthesis" EXACT [] synonym: "'de novo' purine biosynthesis" BROAD [] synonym: "'de novo' purine biosynthetic process" BROAD [] is_a: GO:0006188 ! IMP biosynthetic process [Term] id: GO:0006190 name: inosine salvage namespace: biological_process def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046103 ! inosine biosynthetic process [Term] id: GO:0006191 name: deoxyinosine salvage namespace: biological_process def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043098 ! purine deoxyribonucleoside salvage is_a: GO:0046095 ! deoxyinosine biosynthetic process [Term] id: GO:0006192 name: IDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0006193 name: ITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732] synonym: "ITP breakdown" EXACT [] synonym: "ITP catabolism" EXACT [] synonym: "ITP degradation" EXACT [] synonym: "ITP hydrolysis" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0006194 name: dIDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732] is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process [Term] id: GO:0006195 name: purine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleotide breakdown" EXACT [] synonym: "purine nucleotide catabolism" EXACT [] synonym: "purine nucleotide degradation" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0006196 name: AMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732] synonym: "AMP breakdown" EXACT [] synonym: "AMP catabolism" EXACT [] synonym: "AMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006197 name: obsolete adenylate deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "adenylate deaminase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003876 [Term] id: GO:0006198 name: cAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732] synonym: "3',5' cAMP catabolic process" EXACT [] synonym: "3',5' cAMP catabolism" EXACT [] synonym: "3',5'-cAMP catabolic process" EXACT [] synonym: "3',5'-cAMP catabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "cAMP breakdown" EXACT [] synonym: "cAMP catabolism" EXACT [] synonym: "cAMP degradation" EXACT [] synonym: "cyclic AMP catabolic process" EXACT [] synonym: "cyclic AMP catabolism" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006199 name: obsolete ADP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "ADP reduction" EXACT [] is_obsolete: true consider: GO:0051061 [Term] id: GO:0006200 name: obsolete ATP catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "ATP breakdown" EXACT [] synonym: "ATP catabolism" EXACT [] synonym: "ATP degradation" EXACT [] synonym: "ATP hydrolysis" NARROW [] xref: Wikipedia:ATP_hydrolysis is_obsolete: true consider: GO:0016887 [Term] id: GO:0006201 name: GMP catabolic process to IMP namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732] synonym: "GMP breakdown to IMP" EXACT [] synonym: "GMP degradation to IMP" EXACT [] is_a: GO:0006188 ! IMP biosynthetic process is_a: GO:0046038 ! GMP catabolic process [Term] id: GO:0006202 name: GMP catabolic process to guanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732] synonym: "GMP breakdown to guanine" EXACT [] synonym: "GMP degradation to guanine" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006203 name: dGTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732] synonym: "dGTP breakdown" EXACT [] synonym: "dGTP catabolism" EXACT [] synonym: "dGTP degradation" EXACT [] is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0006204 name: IMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732] synonym: "IMP breakdown" EXACT [] synonym: "IMP catabolism" EXACT [] synonym: "IMP degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006205 name: obsolete pyrimidine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. synonym: "pyrimidine metabolic process" EXACT [] is_obsolete: true consider: GO:0006206 consider: GO:0006213 consider: GO:0006220 [Term] id: GO:0006206 name: pyrimidine nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators] synonym: "pyrimidine base metabolic process" EXACT [GOC:go_curators] synonym: "pyrimidine base metabolism" EXACT [] synonym: "pyrimidine metabolic process" RELATED [] synonym: "pyrimidine metabolism" RELATED [] is_a: GO:0009112 ! nucleobase metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006207 name: 'de novo' pyrimidine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] synonym: "'de novo' pyrimidine base anabolism" EXACT [] synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] synonym: "'de novo' pyrimidine base biosynthetic process" EXACT [GOC:go_curators] synonym: "'de novo' pyrimidine base formation" EXACT [] synonym: "'de novo' pyrimidine base synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine nucleobase biosynthetic process [Term] id: GO:0006208 name: pyrimidine nucleobase catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators] synonym: "pyrimidine base breakdown" EXACT [] synonym: "pyrimidine base catabolic process" EXACT [GOC:go_curators] synonym: "pyrimidine base catabolism" EXACT [] synonym: "pyrimidine base degradation" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0046113 ! nucleobase catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006209 name: cytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] synonym: "cytosine breakdown" EXACT [] synonym: "cytosine catabolism" EXACT [] synonym: "cytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0006210 name: thymine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] synonym: "thymine breakdown" EXACT [] synonym: "thymine catabolism" EXACT [] synonym: "thymine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0006211 name: 5-methylcytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] synonym: "5-methylcytosine breakdown" EXACT [] synonym: "5-methylcytosine catabolism" EXACT [] synonym: "5-methylcytosine degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019857 ! 5-methylcytosine metabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006212 name: uracil catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil breakdown" EXACT [] synonym: "uracil catabolism" EXACT [] synonym: "uracil degradation" EXACT [] is_a: GO:0006208 ! pyrimidine nucleobase catabolic process is_a: GO:0019860 ! uracil metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006213 name: pyrimidine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006214 name: thymidine catabolic process namespace: biological_process alt_id: GO:0006215 def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] synonym: "deoxyribosylthymine catabolic process" EXACT [] synonym: "deoxyribosylthymine catabolism" EXACT [] synonym: "thymidine breakdown" EXACT [] synonym: "thymidine catabolism" EXACT [] synonym: "thymidine degradation" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006216 name: cytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] synonym: "cytidine breakdown" EXACT [] synonym: "cytidine catabolism" EXACT [] synonym: "cytidine degradation" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006217 name: deoxycytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxycytidine breakdown" EXACT [] synonym: "deoxycytidine catabolism" EXACT [] synonym: "deoxycytidine degradation" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006218 name: uridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] synonym: "uridine breakdown" EXACT [] synonym: "uridine catabolism" EXACT [] synonym: "uridine degradation" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006219 name: deoxyuridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] synonym: "deoxyuridine breakdown" EXACT [] synonym: "deoxyuridine catabolism" EXACT [] synonym: "deoxyuridine degradation" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006220 name: pyrimidine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0006221 name: pyrimidine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleotide anabolism" EXACT [] synonym: "pyrimidine nucleotide biosynthesis" EXACT [] synonym: "pyrimidine nucleotide formation" EXACT [] synonym: "pyrimidine nucleotide synthesis" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0006222 name: UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732] synonym: "UMP anabolism" EXACT [] synonym: "UMP biosynthesis" EXACT [] synonym: "UMP formation" EXACT [] synonym: "UMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0006223 name: uracil salvage namespace: biological_process def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] is_a: GO:0043100 ! pyrimidine nucleobase salvage is_a: GO:0046107 ! uracil biosynthetic process [Term] id: GO:0006224 name: obsolete uridine kinase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "uridine kinase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004849 [Term] id: GO:0006225 name: UDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] synonym: "UDP anabolism" EXACT [] synonym: "UDP biosynthesis" EXACT [] synonym: "UDP formation" EXACT [] synonym: "UDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006226 name: dUMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732] synonym: "dUMP anabolism" EXACT [] synonym: "dUMP biosynthesis" EXACT [] synonym: "dUMP formation" EXACT [] synonym: "dUMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0006227 name: dUDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732] synonym: "dUDP anabolism" EXACT [] synonym: "dUDP biosynthesis" EXACT [] synonym: "dUDP formation" EXACT [] synonym: "dUDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006228 name: UTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732] synonym: "UTP anabolism" EXACT [] synonym: "UTP biosynthesis" EXACT [] synonym: "UTP formation" EXACT [] synonym: "UTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0006229 name: dUTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732] synonym: "dUTP anabolism" EXACT [] synonym: "dUTP biosynthesis" EXACT [] synonym: "dUTP formation" EXACT [] synonym: "dUTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0006230 name: TMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732] synonym: "TMP anabolism" EXACT [] synonym: "TMP biosynthesis" EXACT [] synonym: "TMP formation" EXACT [] synonym: "TMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0006231 name: dTMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732] synonym: "dTMP anabolism" EXACT [] synonym: "dTMP biosynthesis" EXACT [] synonym: "dTMP formation" EXACT [] synonym: "dTMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0006232 name: TDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732] synonym: "TDP anabolism" EXACT [] synonym: "TDP biosynthesis" EXACT [] synonym: "TDP formation" EXACT [] synonym: "TDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006233 name: dTDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732] synonym: "dTDP anabolism" EXACT [] synonym: "dTDP biosynthesis" EXACT [] synonym: "dTDP formation" EXACT [] synonym: "dTDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006234 name: TTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732] synonym: "TTP anabolism" EXACT [] synonym: "TTP biosynthesis" EXACT [] synonym: "TTP formation" EXACT [] synonym: "TTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0006235 name: dTTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732] synonym: "dTTP anabolism" EXACT [] synonym: "dTTP biosynthesis" EXACT [] synonym: "dTTP formation" EXACT [] synonym: "dTTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0006236 name: cytidine salvage namespace: biological_process def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046088 ! cytidine biosynthetic process [Term] id: GO:0006237 name: deoxycytidine salvage namespace: biological_process def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage is_a: GO:0046093 ! deoxycytidine biosynthetic process [Term] id: GO:0006238 name: CMP salvage namespace: biological_process def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "cytidine monophosphate salvage" EXACT [] is_a: GO:0009224 ! CMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0006239 name: dCMP salvage namespace: biological_process def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] synonym: "deoxycytidine monophosphate salvage" EXACT [] is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage is_a: GO:0046064 ! dCMP biosynthetic process [Term] id: GO:0006240 name: dCDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] synonym: "dCDP anabolism" EXACT [] synonym: "dCDP biosynthesis" EXACT [] synonym: "dCDP formation" EXACT [] synonym: "dCDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006241 name: CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] synonym: "CTP anabolism" EXACT [] synonym: "CTP biosynthesis" EXACT [] synonym: "CTP formation" EXACT [] synonym: "CTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006242 name: dCTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] synonym: "dCTP anabolism" EXACT [] synonym: "dCTP biosynthesis" EXACT [] synonym: "dCTP formation" EXACT [] synonym: "dCTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006244 name: pyrimidine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleotide breakdown" EXACT [] synonym: "pyrimidine nucleotide catabolism" EXACT [] synonym: "pyrimidine nucleotide degradation" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0072529 ! pyrimidine-containing compound catabolic process [Term] id: GO:0006245 name: TDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732] synonym: "TDP breakdown" EXACT [] synonym: "TDP catabolism" EXACT [] synonym: "TDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006246 name: dTDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732] synonym: "dTDP breakdown" EXACT [] synonym: "dTDP catabolism" EXACT [] synonym: "dTDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006247 name: obsolete TTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "TTP reduction" EXACT [] is_obsolete: true consider: GO:0051064 [Term] id: GO:0006248 name: CMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732] synonym: "CMP breakdown" EXACT [] synonym: "CMP catabolism" EXACT [] synonym: "CMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0006249 name: dCMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732] synonym: "dCMP breakdown" EXACT [] synonym: "dCMP catabolism" EXACT [] synonym: "dCMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0006250 name: obsolete CDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "CDP reduction" EXACT [] is_obsolete: true consider: GO:0051063 [Term] id: GO:0006251 name: dCDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732] synonym: "dCDP breakdown" EXACT [] synonym: "dCDP catabolism" EXACT [] synonym: "dCDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006252 name: obsolete CTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "CTP reduction" EXACT [] is_obsolete: true consider: GO:0051065 [Term] id: GO:0006253 name: dCTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732] synonym: "dCTP breakdown" EXACT [] synonym: "dCTP catabolism" EXACT [] synonym: "dCTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006254 name: CTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732] synonym: "CTP breakdown" EXACT [] synonym: "CTP catabolism" EXACT [] synonym: "CTP degradation" EXACT [] synonym: "CTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006255 name: obsolete UDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "UDP reduction" EXACT [] is_obsolete: true consider: GO:0051062 [Term] id: GO:0006256 name: UDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732] synonym: "UDP breakdown" EXACT [] synonym: "UDP catabolism" EXACT [] synonym: "UDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006257 name: dUDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732] synonym: "dUDP breakdown" EXACT [] synonym: "dUDP catabolism" EXACT [] synonym: "dUDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006258 name: UDP-glucose catabolic process namespace: biological_process alt_id: GO:0019691 def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucose breakdown" EXACT [] synonym: "UDP-glucose catabolism" EXACT [] synonym: "UDP-glucose conversion" RELATED [] synonym: "UDP-glucose degradation" EXACT [] is_a: GO:0006011 ! UDP-glucose metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006260 name: DNA replication namespace: biological_process alt_id: GO:0055133 def: "The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA." [GOC:mah] comment: DNA biosynthesis is only part of this process. See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_pir subset: goslim_pombe subset: goslim_yeast xref: Wikipedia:DNA_replication is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0006261 name: DNA-dependent DNA replication namespace: biological_process alt_id: GO:0006262 alt_id: GO:0006263 def: "A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [GOC:mah, ISBN:0198506732] is_a: GO:0006260 ! DNA replication [Term] id: GO:0006264 name: mitochondrial DNA replication namespace: biological_process def: "The process in which new strands of DNA are synthesized in the mitochondrion." [GOC:ai] synonym: "mitochondrial DNA synthesis" RELATED [] synonym: "mtDNA replication" EXACT [] synonym: "mtDNA synthesis" RELATED [] synonym: "replication of mitochondrial DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006265 name: DNA topological change namespace: biological_process def: "The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. synonym: "DNA underwinding" NARROW [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006266 name: DNA ligation namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006267 name: pre-replicative complex assembly involved in nuclear cell cycle DNA replication namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the nuclear pre-replicative complex, a protein-DNA complex that forms at the eukaryotic DNA replication origin and is required for replication initiation." [GOC:mtg_cell_cycle] synonym: "nuclear pre-replicative complex assembly" EXACT [] synonym: "pre-RC complex assembly" BROAD [] synonym: "pre-replicative complex assembly" BROAD [GOC:bf, GOC:bhm, GOC:jh2] synonym: "pre-replicative complex formation" BROAD [] is_a: GO:1902299 ! pre-replicative complex assembly involved in cell cycle DNA replication relationship: part_of GO:0033260 ! nuclear DNA replication [Term] id: GO:0006268 name: DNA unwinding involved in DNA replication namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb] synonym: "DNA unwinding factor" RELATED [] is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006269 name: DNA replication, synthesis of RNA primer namespace: biological_process def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] synonym: "replication priming" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006270 name: DNA replication initiation namespace: biological_process alt_id: GO:0042024 def: "The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate." [ISBN:071673706X, ISBN:0815316194, PMID:28209641] synonym: "DNA endoreduplication initiation" NARROW [] synonym: "DNA re-replication initiation" NARROW [] synonym: "DNA-dependent DNA replication initiation" EXACT [GOC:vw] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006271 name: DNA strand elongation involved in DNA replication namespace: biological_process def: "The process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 synonym: "DNA replication elongation" EXACT [] synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006272 name: leading strand elongation namespace: biological_process def: "The process in which an existing DNA strand is extended continuously in a 5' to 3' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Leading strand elongation proceeds in the same direction as the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006271 ! DNA strand elongation involved in DNA replication [Term] id: GO:0006273 name: lagging strand elongation namespace: biological_process def: "The process in which an existing DNA strand is extended in a net 3' to 5' direction by activities including the addition of nucleotides to the 3' end of the strand, complementary to an existing template, as part of DNA replication. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [GOC:mah, ISBN:071673706X, ISBN:0815316194] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006271 ! DNA strand elongation involved in DNA replication [Term] id: GO:0006274 name: DNA replication termination namespace: biological_process def: "The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006275 name: regulation of DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006260 ! DNA replication [Term] id: GO:0006276 name: plasmid maintenance namespace: biological_process def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0006277 name: DNA amplification namespace: biological_process def: "The process in which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006278 name: RNA-dependent DNA biosynthetic process namespace: biological_process def: "A DNA biosynthetic process that uses RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strand." [GOC:mah, ISBN:0198506732] is_a: GO:0071897 ! DNA biosynthetic process [Term] id: GO:0006279 name: premeiotic DNA replication namespace: biological_process alt_id: GO:1902968 def: "The replication of DNA that precedes meiotic cell division." [GO_REF:0000060, GOC:ai, GOC:TermGenie] synonym: "DNA replication during S phase involved in meiotic cell cycle" RELATED [GOC:TermGenie] synonym: "DNA replication involved in S phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "DNA replication involved in S-phase involved in meiotic cell cycle" EXACT [GOC:TermGenie] synonym: "meiotic cell cycle DNA replication" EXACT [] synonym: "meiotic DNA replication" RELATED [GOC:mah] synonym: "meiotic DNA synthesis" RELATED [GOC:mah] synonym: "meiotic nuclear cell cycle DNA replication" EXACT [] synonym: "nuclear cell cycle DNA replication involved in meiotic cell cycle" EXACT [] synonym: "premeiotic DNA synthesis" RELATED [GOC:mah] is_a: GO:0033260 ! nuclear DNA replication is_a: GO:1903046 ! meiotic cell cycle process [Term] id: GO:0006280 name: obsolete mutagenesis namespace: biological_process def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732] comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. synonym: "mutagenesis" EXACT [] is_obsolete: true consider: GO:0006281 consider: GO:0051276 [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! cellular response to DNA damage stimulus [Term] id: GO:0006282 name: regulation of DNA repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:2001020 ! regulation of response to DNA damage stimulus relationship: regulates GO:0006281 ! DNA repair [Term] id: GO:0006283 name: transcription-coupled nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] synonym: "TC-NER" EXACT [PMID:10197977] synonym: "TCR" RELATED [GOC:vw, PMID:18794354] synonym: "transcription-coupled NER" EXACT [GOC:mah] synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354] is_a: GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006284 name: base-excision repair namespace: biological_process def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] synonym: "BER" EXACT [] xref: Wikipedia:Base_excision_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006285 name: base-excision repair, AP site formation namespace: biological_process def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006286 name: base-excision repair, base-free sugar-phosphate removal namespace: biological_process def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0098502 ! DNA dephosphorylation relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006287 name: base-excision repair, gap-filling namespace: biological_process def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006288 name: base-excision repair, DNA ligation namespace: biological_process def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] is_a: GO:0051103 ! DNA ligation involved in DNA repair relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006289 name: nucleotide-excision repair namespace: biological_process alt_id: GO:0045001 def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. synonym: "intrastrand cross-link repair" RELATED [] synonym: "NER" EXACT [] synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] is_a: GO:0006281 ! DNA repair [Term] id: GO:0006290 name: pyrimidine dimer repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] is_a: GO:0006281 ! DNA repair [Term] id: GO:0006291 name: obsolete pyrimidine-dimer repair, DNA damage excision namespace: biological_process def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] comment: This term was made obsolete because this process can be subdivided into multiple processes. synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] is_obsolete: true consider: GO:0006289 [Term] id: GO:0006292 name: obsolete pyrimidine-dimer repair, DNA damage recognition namespace: biological_process def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] comment: This term was made obsolete because it is a substrate specific DNA repair process. synonym: "pyrimidine-dimer repair, DNA damage recognition" EXACT [] is_obsolete: true consider: GO:0000715 consider: GO:0000716 [Term] id: GO:0006293 name: nucleotide-excision repair, preincision complex stabilization namespace: biological_process def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] is_a: GO:0031334 ! positive regulation of protein complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006294 name: nucleotide-excision repair, preincision complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006295 name: nucleotide-excision repair, DNA incision, 3'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006296 name: nucleotide-excision repair, DNA incision, 5'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006297 name: nucleotide-excision repair, DNA gap filling namespace: biological_process def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006298 name: mismatch repair namespace: biological_process alt_id: GO:0006300 def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732, PMID:11687886] synonym: "long patch mismatch repair system" NARROW [] synonym: "mismatch repair, MutL-like pathway" RELATED [] synonym: "MMR" EXACT [] synonym: "MutS/MutL/MutH pathway" RELATED [] xref: Wikipedia:DNA_mismatch_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006299 name: obsolete short patch mismatch repair system namespace: biological_process def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. synonym: "short patch mismatch repair system" EXACT [] is_obsolete: true consider: GO:0006284 consider: GO:0006289 [Term] id: GO:0006301 name: postreplication repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] synonym: "postreplication DNA repair" EXACT [GOC:curators] xref: Wikipedia:Postreplication_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006302 name: double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] comment: Note that the processes of nuclear double-strand break repair and mitochondrial double-strand break repair are genetically separable (PMID:22214610). To annotate gene products involved in mitochondrial double-strand break repair, please use GO:0097551 'mitochondrial double-strand break repair'. is_a: GO:0006281 ! DNA repair [Term] id: GO:0006303 name: double-strand break repair via nonhomologous end joining namespace: biological_process def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear." [GOC:rph, PMID:10827453, PMID:24837021] synonym: "NHEJ" EXACT [] is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0006304 name: DNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0006305 name: DNA alkylation namespace: biological_process def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] is_a: GO:0006304 ! DNA modification [Term] id: GO:0006306 name: DNA methylation namespace: biological_process def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732] xref: Wikipedia:DNA_methylation is_a: GO:0006305 ! DNA alkylation is_a: GO:0043414 ! macromolecule methylation is_a: GO:0044728 ! DNA methylation or demethylation [Term] id: GO:0006307 name: DNA dealkylation involved in DNA repair namespace: biological_process def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] is_a: GO:0035510 ! DNA dealkylation relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732] synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006309 name: apoptotic DNA fragmentation namespace: biological_process alt_id: GO:0008178 def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976, PMID:15723341, PMID:23379520] comment: DNA fragmentation in response to apoptotic signals is achieved through the activity of apoptotic nucleases. In human, these include DNA fragmentation factor (DFF) or caspase-activated DNase (CAD) and endonuclease G (Endo G) (reviewed in PMID:15723341). Caution is needed when apoptotic DNA laddering assays show presence of fragmented DNA. A positive assay may simply reflect the end point of a whole apoptotic process. Unless clear experimental evidence is available to show that a gene product is directly involved in fragmenting DNA, please do not annotate to GO:0006309 'apoptotic DNA fragmentation' and consider annotating instead to a more upstream process such as, e.g., GO:0042981 'regulation of apoptotic process', GO:0006915 'apoptotic process', GO:0097190 'apoptotic signaling pathway'. Also, note that gene products involved in compartmentalization of apoptotic nucleases and in activation or repression of their enzymatic activity should be annotated to the regulation term GO:1902510 'regulation of apoptotic DNA fragmentation' or to one of its children (see PMID:15723341). synonym: "chromatinolysis" BROAD [GOC:mtg_apoptosis] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "DNA fragmentation involved in apoptotic nuclear change" EXACT [GOC:cjm, GOC:dph, GOC:tb] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] is_a: GO:0000737 ! DNA catabolic process, endonucleolytic relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732] subset: goslim_pombe subset: goslim_yeast is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006311 name: meiotic gene conversion namespace: biological_process def: "The cell cycle process in which genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] synonym: "gene conversion without reciprocal crossover" EXACT [] is_a: GO:0035822 ! gene conversion is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0006312 name: mitotic recombination namespace: biological_process def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] xref: Wikipedia:Mitotic_crossover is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006313 name: transposition, DNA-mediated namespace: biological_process alt_id: GO:0006317 alt_id: GO:0006318 def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732, ISBN:1555812090] synonym: "Class II transposition" EXACT [] synonym: "DNA transposition" EXACT [GOC:dph] synonym: "P-element excision" NARROW [] synonym: "P-element transposition" NARROW [] synonym: "Tc1/mariner transposition" NARROW [] synonym: "Tc3 transposition" NARROW [] is_a: GO:0006310 ! DNA recombination is_a: GO:0032196 ! transposition [Term] id: GO:0006314 name: intron homing namespace: biological_process def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006315 name: homing of group II introns namespace: biological_process def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] is_a: GO:0006314 ! intron homing [Term] id: GO:0006316 name: movement of group I intron namespace: biological_process def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] is_a: GO:0006314 ! intron homing [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process in which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA condensation" EXACT [] synonym: "DNA organisation" EXACT [GOC:curators] synonym: "DNA organization" EXACT [GOC:curators] is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006324 name: obsolete S phase-specific histone modification namespace: biological_process def: "OBSOLETE. The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] comment: This term was made obsolete because histone modification already exists and the phase specificity is better captured as an annotation extension. synonym: "S phase-specific histone modification" EXACT [] synonym: "S-phase-specific histone modification" EXACT [] is_obsolete: true consider: GO:0016570 [Term] id: GO:0006325 name: chromatin organization namespace: biological_process alt_id: GO:0016568 def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah, GOC:vw, PMID:20404130] subset: goslim_pombe subset: goslim_yeast synonym: "chromatin modification" RELATED [] synonym: "chromatin organisation" EXACT [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0051276 ! chromosome organization [Term] id: GO:0006326 name: obsolete bent DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "bent DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003681 [Term] id: GO:0006327 name: obsolete random coil binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "random coil binding" EXACT [] is_obsolete: true consider: GO:0003695 [Term] id: GO:0006328 name: obsolete AT binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "AT binding" EXACT [] is_obsolete: true replaced_by: GO:0003680 [Term] id: GO:0006329 name: obsolete satellite DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "satellite DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003696 [Term] id: GO:0006330 name: obsolete single-stranded DNA binding namespace: biological_process alt_id: GO:0006331 alt_id: GO:0006332 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "single-stranded DNA binding" EXACT [] is_obsolete: true replaced_by: GO:0003697 [Term] id: GO:0006333 name: chromatin assembly or disassembly namespace: biological_process def: "The formation or destruction of chromatin structures." [GOC:mah] synonym: "chromatin assembly/disassembly" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006334 name: nucleosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] synonym: "histone chaperone" RELATED [GOC:vw] synonym: "nucleosome modeling" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0031497 ! chromatin assembly [Term] id: GO:0006335 name: DNA replication-dependent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0006336 name: DNA replication-independent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] synonym: "transcription-coupled nucleosome assembly" EXACT [] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0006337 name: nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] is_a: GO:0032986 ! protein-DNA complex disassembly is_a: GO:0034728 ! nucleosome organization relationship: part_of GO:0031498 ! chromatin disassembly [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, GOC:vw, PMID:12697820] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006339 name: obsolete positive regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "positive regulation of transcription of homeotic gene (trithorax group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006340 name: obsolete negative regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. synonym: "negative regulation of transcription of homeotic gene (Polycomb group)" EXACT [] is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006341 name: obsolete chromatin insulator sequence binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "chromatin insulator sequence binding" EXACT [] is_obsolete: true replaced_by: GO:0043035 [Term] id: GO:0006342 name: chromatin silencing namespace: biological_process alt_id: GO:0016440 def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "heterochromatic silencing" RELATED [] synonym: "TGS" EXACT [] synonym: "transcriptional gene silencing" EXACT [] is_a: GO:0016458 ! gene silencing is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0045892 ! negative regulation of transcription, DNA-templated is_a: GO:0097549 ! chromatin organization involved in negative regulation of transcription [Term] id: GO:0006343 name: establishment of chromatin silencing namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah] synonym: "establishment of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006344 name: maintenance of chromatin silencing namespace: biological_process def: "The maintenance of chromatin in a transcriptionally silent state such as heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006346 name: methylation-dependent chromatin silencing namespace: biological_process def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] synonym: "methylation-dependent heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0006348 name: chromatin silencing at telomere namespace: biological_process def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] synonym: "heterochromatic silencing at telomere" EXACT [] synonym: "telomere chromatin silencing" EXACT [GOC:mah] synonym: "Telomere Position Effect" EXACT [GOC:BHF, GOC:BHF_telomere, GOC:nc, PMID:21847107] synonym: "telomeric silencing" EXACT [GOC:bf] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0006349 name: regulation of gene expression by genetic imprinting namespace: biological_process def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732, PMID:11498578] synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah] xref: Wikipedia:Genomic_imprinting is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0071514 ! genetic imprinting [Term] id: GO:0006351 name: transcription, DNA-templated namespace: biological_process alt_id: GO:0006350 alt_id: GO:0061018 alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl, GOC:txnOH] subset: goslim_aspergillus subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cellular transcription" BROAD [] synonym: "cellular transcription, DNA-dependent" EXACT [] synonym: "DNA-dependent transcription" EXACT [] synonym: "transcription" BROAD [] synonym: "transcription regulator activity" RELATED [] synonym: "transcription, DNA-dependent" EXACT [GOC:txnOH] xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0097659 ! nucleic acid-templated transcription relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006352 name: DNA-templated transcription, initiation namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase preinitiation complex (PIC) at the core promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. The initiation phase ends just before and does not include promoter clearance, or release, which is the transition between the initiation and elongation phases of transcription." [GOC:jid, GOC:txnOH, PMID:18280161] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. subset: goslim_yeast synonym: "DNA-dependent RNA polymerase complex assembly at promoter" EXACT [] synonym: "DNA-dependent transcription, initiation" EXACT [GOC:txnOH] synonym: "initiation of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "initiation of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription initiation factor activity" RELATED [] synonym: "transcription initiation, DNA-dependent" RELATED [GOC:jh2] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006353 name: DNA-templated transcription, termination namespace: biological_process def: "The cellular process that completes DNA-templated transcription; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:txnOH, ISBN:0716720094, PMID:15020047, PMID:18280161] subset: goslim_yeast synonym: "DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "termination of transcription, DNA-dependent" EXACT [GOC:mah] synonym: "transcription termination factor activity" RELATED [] synonym: "transcription termination, DNA-dependent" RELATED [GOC:jh2] synonym: "transcriptional complex disassembly" BROAD [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006354 name: DNA-templated transcription, elongation namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah, GOC:txnOH, PMID:15020047, PMID:18280161] subset: goslim_pir subset: goslim_yeast synonym: "DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "RNA elongation" BROAD [] synonym: "transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "transcriptional elongation, DNA-dependent" EXACT [] is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006355 name: regulation of transcription, DNA-templated namespace: biological_process alt_id: GO:0032583 alt_id: GO:0045449 alt_id: GO:0061019 def: "Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "regulation of gene-specific transcription" RELATED [] synonym: "regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "transcriptional control" BROAD [] is_a: GO:0010468 ! regulation of gene expression is_a: GO:1903506 ! regulation of nucleic acid-templated transcription is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006356 name: regulation of transcription by RNA polymerase I namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] synonym: "regulation of transcription from Pol I promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: regulates GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006357 name: regulation of transcription by RNA polymerase II namespace: biological_process alt_id: GO:0006358 alt_id: GO:0010551 def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II." [GOC:go_curators, GOC:txnOH] synonym: "global transcription regulation from Pol II promoter" RELATED [] synonym: "regulation of gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "regulation of global transcription from Pol II promoter" RELATED [] synonym: "regulation of transcription from Pol II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase II promoter, global" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: regulates GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006359 name: regulation of transcription by RNA polymerase III namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription mediated by RNA ploymerase III." [GOC:go_curators] synonym: "regulation of transcription from Pol III promoter" EXACT [] synonym: "regulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: regulates GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006360 name: transcription by RNA polymerase I namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase I (RNAP I), originating at an RNAP I promoter." [GOC:jl, GOC:txnOH] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 subset: goslim_yeast synonym: "RNA polymerase I transcription factor activity" RELATED [] synonym: "transcription from Pol I promoter" EXACT [] synonym: "transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006361 name: transcription initiation from RNA polymerase I promoter namespace: biological_process alt_id: GO:0001180 def: "Any process involved in the assembly of the RNA polymerase I preinitiation complex (PIC) at an RNA polymerase I promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol I promoter" EXACT [] synonym: "transcription initiation from RNA polymerase I promoter for nuclear large rRNA transcript" NARROW [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006362 name: transcription elongation from RNA polymerase I promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase I specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol I promoter" EXACT [] synonym: "RNA polymerase I transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006363 name: termination of RNA polymerase I transcription namespace: biological_process alt_id: GO:0001185 alt_id: GO:0019223 def: "The process in which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed. RNAP I termination requires binding of a terminator protein so specific sequences downstream of the transcription unit." [GOC:mah, GOC:txnOH, PMID:10684922] synonym: "RNA polymerase I transcription termination" EXACT [] synonym: "RNA polymerase I transcription termination factor activity" RELATED [] synonym: "termination of RNA polymerase I transcription from promoter for nuclear large rRNA transcript" NARROW [] synonym: "transcription termination from Pol I promoter" EXACT [] synonym: "transcription termination from RNA polymerase I promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0006364 name: rRNA processing namespace: biological_process alt_id: GO:0006365 def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] subset: goslim_yeast synonym: "35S primary transcript processing" NARROW [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006366 name: transcription by RNA polymerase II namespace: biological_process alt_id: GO:0032568 alt_id: GO:0032569 def: "The synthesis of RNA from a DNA template by RNA polymerase II (RNAP II), originating at an RNA polymerase II promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, GOC:txnOH, ISBN:0321000382] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 subset: goslim_yeast synonym: "gene-specific transcription from RNA polymerase II promoter" RELATED [] synonym: "general transcription from RNA polymerase II promoter" RELATED [] synonym: "RNA polymerase II transcription factor activity" RELATED [] synonym: "specific transcription from RNA polymerase II promoter" RELATED [GOC:mah] synonym: "transcription from Pol II promoter" EXACT [] synonym: "transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006367 name: transcription initiation from RNA polymerase II promoter namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol II promoter" EXACT [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006368 name: transcription elongation from RNA polymerase II promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase II promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol II promoter" EXACT [] synonym: "RNA polymerase II transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006369 name: termination of RNA polymerase II transcription namespace: biological_process alt_id: GO:0019224 def: "The process in which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah, GOC:txnOH] synonym: "RNA 3'-end formation by RNA polymerase II" EXACT [] synonym: "RNA polymerase II transcription termination" EXACT [] synonym: "RNA polymerase II transcription termination factor activity" RELATED [] synonym: "transcription termination from Pol II promoter" EXACT [] synonym: "transcription termination from RNA polymerase II promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006366 ! transcription by RNA polymerase II [Term] id: GO:0006370 name: 7-methylguanosine mRNA capping namespace: biological_process def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] synonym: "5' end capping" BROAD [] synonym: "5' mRNA capping" EXACT [] synonym: "5'-end mRNA processing" EXACT [] synonym: "5'-end processing" BROAD [] synonym: "mRNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] is_a: GO:0006397 ! mRNA processing is_a: GO:0009452 ! 7-methylguanosine RNA capping [Term] id: GO:0006371 name: obsolete mRNA splicing namespace: biological_process def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732] comment: This term was made obsolete because it represents several different processes. synonym: "mRNA splicing" EXACT [] is_obsolete: true consider: GO:0000372 consider: GO:0000373 consider: GO:0000374 consider: GO:0000394 consider: GO:0000398 [Term] id: GO:0006372 name: obsolete lariat formation, 5'-splice site cleavage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. synonym: "lariat formation, 5'-splice site cleavage" EXACT [] is_obsolete: true consider: GO:0000350 consider: GO:0000386 [Term] id: GO:0006373 name: obsolete 3'-splice site cleavage, exon ligation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. synonym: "3'-splice site cleavage, exon ligation" EXACT [] is_obsolete: true consider: GO:0000386 consider: GO:0000388 consider: GO:0000393 [Term] id: GO:0006376 name: mRNA splice site selection namespace: biological_process def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosomal complex assembly [Term] id: GO:0006377 name: obsolete MATa1 (A1) pre-mRNA splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. synonym: "MATa1 (A1) pre-mRNA splicing" EXACT [] is_obsolete: true consider: GO:0000244 [Term] id: GO:0006378 name: mRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732] synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] synonym: "mRNA polyadenylylation" EXACT [] is_a: GO:0031124 ! mRNA 3'-end processing is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0006379 name: mRNA cleavage namespace: biological_process def: "Any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] synonym: "cleavage stimulation factor activity" RELATED [] is_a: GO:0090501 ! RNA phosphodiester bond hydrolysis [Term] id: GO:0006380 name: obsolete poly-A binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "poly-A binding" EXACT [] is_obsolete: true consider: GO:0008143 [Term] id: GO:0006382 name: adenosine to inosine editing namespace: biological_process def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0006383 name: transcription by RNA polymerase III namespace: biological_process alt_id: GO:0001009 alt_id: GO:0001035 alt_id: GO:0001041 def: "The synthesis of RNA from a DNA template by RNA polymerase III, originating at an RNAP III promoter." [GOC:jl, GOC:txnOH, PMID:12381659] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854\nMerged terms as requested in https://github.com/geneontology/go-ontology/issues/9617 subset: goslim_yeast synonym: "RNA polymerase III transcription factor activity" RELATED [] synonym: "transcription from a RNA polymerase III hybrid type promoter" NARROW [] synonym: "transcription from Pol III promoter" EXACT [] synonym: "transcription from RNA polymerase III promoter" EXACT [] synonym: "transcription from RNA polymerase III type 2 promoter" NARROW [] synonym: "transcription from RNA polymerase III type 3 promoter" NARROW [] synonym: "U2 snRNA transcription (S. cerevisiae)" NARROW [] synonym: "U6 snRNA transcription (mammalian)" NARROW [] is_a: GO:0006351 ! transcription, DNA-templated [Term] id: GO:0006384 name: transcription initiation from RNA polymerase III promoter namespace: biological_process alt_id: GO:0001022 alt_id: GO:0001023 alt_id: GO:0001024 alt_id: GO:0001036 def: "Any process involved in the assembly of the RNA polymerase III preinitiation complex (PIC) at an RNA polymerase III promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter. The initiation phase includes PIC assembly and the formation of the first few bonds in the RNA chain, including abortive initiation, which occurs when the first few nucleotides are repeatedly synthesized and then released. Promoter clearance, or release, is the transition between the initiation and elongation phases of transcription." [GOC:mah, GOC:txnOH] comment: Note that promoter clearance is represented as a separate step, not part_of either initiation or elongation. synonym: "transcription initiation from Pol III promoter" EXACT [] synonym: "transcription initiation from RNA polymerase III hybrid type promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 1 promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 2 promoter" NARROW [] synonym: "transcription initiation from RNA polymerase III type 3 promoter" NARROW [] is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006385 name: transcription elongation from RNA polymerase III promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at an RNA polymerase III promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from Pol III promoter" EXACT [] synonym: "RNA polymerase III transcription elongation factor activity" RELATED [] is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006386 name: termination of RNA polymerase III transcription namespace: biological_process alt_id: GO:0019225 def: "The process in which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] synonym: "RNA polymerase III transcription termination" EXACT [] synonym: "RNA polymerase III transcription termination factor activity" RELATED [] synonym: "transcription termination from Pol III promoter" EXACT [] synonym: "transcription termination from RNA polymerase III promoter" EXACT [] is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0006387 name: obsolete snRNA capping namespace: biological_process def: "OBSOLETE. The sequence of enzymatic reactions resulting in the addition of a cap to the 5' end of a nascent snRNA transcript." [GOC:mah] comment: This term was made obsolete because it has been replaced with a more specific term to describe cap hypermethylation. All RNA polymerase II transcripts receive a 7-methyl-G cap. Then for (at least) small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs), the 7-methyl-G cap is hypermethylated to become a 2,2,7-trimethylguanosine (TMG) cap. synonym: "snRNA capping" EXACT [] is_obsolete: true consider: GO:0036261 [Term] id: GO:0006388 name: tRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. synonym: "tRNA-Y splicing" NARROW [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0008033 ! tRNA processing [Term] id: GO:0006389 name: obsolete tRNA-Y splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. synonym: "tRNA-Y splicing" EXACT [] is_obsolete: true consider: GO:0006388 [Term] id: GO:0006390 name: mitochondrial transcription namespace: biological_process def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] comment: Changed class label as requested in https://github.com/geneontology/go-ontology/issues/14854 synonym: "transcription from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006351 ! transcription, DNA-templated relationship: part_of GO:0140053 ! mitochondrial gene expression [Term] id: GO:0006391 name: transcription initiation from mitochondrial promoter namespace: biological_process def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006352 ! DNA-templated transcription, initiation relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006392 name: transcription elongation from mitochondrial promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation and promoter clearance at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "RNA elongation from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006354 ! DNA-templated transcription, elongation relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006393 name: termination of mitochondrial transcription namespace: biological_process def: "The process in which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] synonym: "mitochondrial transcription termination" EXACT [] synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006353 ! DNA-templated transcription, termination relationship: part_of GO:0006390 ! mitochondrial transcription [Term] id: GO:0006396 name: RNA processing namespace: biological_process alt_id: GO:0006394 def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] subset: goslim_pir xref: Wikipedia:Post-transcriptional_modification is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "mRNA maturation" RELATED [] is_a: GO:0006396 ! RNA processing is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006398 name: mRNA 3'-end processing by stem-loop binding and cleavage namespace: biological_process def: "Any mRNA 3'-end processing that involves the binding to and cleavage of a stem-loop structure. For example, histone mRNAs contain a highly conserved stem-loop sequence at the 3' end of the mRNA with a 6 base pairs (bp) stem and a 4-nt loop. The mRNA is cleaved between these two elements, after the fourth or fifth nucleotide, which is typically an adenosine." [GOC:mah, GOC:tb, PMID:17998288] synonym: "histone mRNA 3' end processing" NARROW [] is_a: GO:0008334 ! histone mRNA metabolic process is_a: GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "tRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0006400 name: tRNA modification namespace: biological_process alt_id: GO:0016549 def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "tRNA editing" NARROW [GOC:hjd] is_a: GO:0008033 ! tRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_yeast synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034655 ! nucleobase-containing compound catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006402 name: mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] synonym: "mRNA breakdown" EXACT [] synonym: "mRNA catabolism" EXACT [] synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] synonym: "mRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process in which RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of RNA localization" EXACT [] synonym: "RNA localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! import into nucleus [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006406 name: mRNA export from nucleus namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "mRNA export from cell nucleus" EXACT [] synonym: "mRNA export out of nucleus" EXACT [] synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "mRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051028 ! mRNA transport relationship: part_of GO:0010467 ! gene expression relationship: part_of GO:0071427 ! mRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006407 name: rRNA export from nucleus namespace: biological_process def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah] synonym: "rRNA export from cell nucleus" EXACT [] synonym: "rRNA export out of nucleus" EXACT [] synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] synonym: "rRNA-nucleus export" EXACT [] is_a: GO:0051029 ! rRNA transport is_a: GO:0097064 ! ncRNA export from nucleus relationship: part_of GO:0042254 ! ribosome biogenesis relationship: part_of GO:0071428 ! rRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006408 name: snRNA export from nucleus namespace: biological_process def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "snRNA export from cell nucleus" EXACT [] synonym: "snRNA export out of nucleus" EXACT [] synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] synonym: "snRNA-nucleus export" EXACT [] is_a: GO:0051030 ! snRNA transport is_a: GO:0097064 ! ncRNA export from nucleus [Term] id: GO:0006409 name: tRNA export from nucleus namespace: biological_process def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "tRNA export from cell nucleus" EXACT [] synonym: "tRNA export out of nucleus" EXACT [] synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] synonym: "tRNA-nucleus export" EXACT [] is_a: GO:0051031 ! tRNA transport is_a: GO:0097064 ! ncRNA export from nucleus relationship: part_of GO:0071431 ! tRNA-containing ribonucleoprotein complex export from nucleus [Term] id: GO:0006410 name: obsolete transcription, RNA-dependent namespace: biological_process def: "OBSOLETE: The cellular synthesis of DNA on a template of RNA." [GOC:jl] comment: This term was obsoleted because the name and the definition mean two completely different things: 1) "transcription, RNA-dependent", i.e. RNA-dependent production of an RNA transcript and 2) "reverse transcription", i.e. RNA-dependent DNA synthesis. synonym: "transcription, RNA-dependent" EXACT [] is_obsolete: true [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Wikipedia:Translation_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044267 ! cellular protein metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: goslim_yeast synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: goslim_yeast synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] subset: goslim_yeast synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0034248 ! regulation of cellular amide metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0006412 ! translation [Term] id: GO:0006418 name: tRNA aminoacylation for protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] subset: goslim_yeast synonym: "tRNA charging" NARROW [] xref: MetaCyc:TRNA-CHARGING-PWY is_a: GO:0043039 ! tRNA aminoacylation relationship: part_of GO:0006412 ! translation [Term] id: GO:0006419 name: alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. The alanyl-tRNA synthetase is a class-II synthetases. The activated amino acid is transferred to the 3'-OH group of an alanine accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006420 name: arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. The arginyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of an alanine accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006421 name: asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. The asparaginyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an asparagine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006422 name: aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. The aspartyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of an aspartic acid accetping tRNA." [GOC:mah, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006423 name: cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. A cysteinyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a cysteine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006424 name: glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. The glutamyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamic acid-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006425 name: glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. The glutaminyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a glutamine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006426 name: glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006427 name: histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. The histidyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3''-OH group of a histidine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006428 name: isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. The isoleucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a isoleucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006429 name: leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006430 name: lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. The lysyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a lysine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006431 name: methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. The methionyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a methionine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006432 name: phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006433 name: prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. The prolyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a methionine-accetping tRNA." [GOC:mah, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006434 name: seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. The seryl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a serine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006435 name: threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. The threonyl-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a threonine-accetping tRNA." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006436 name: tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006437 name: tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase.The tyrosyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tyrosine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification.T" [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006438 name: valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. The valyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a valine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification." [GOC:mcc, ISBN:0716730510] is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006439 name: obsolete aminoacyl-tRNA hydrolase reaction namespace: biological_process def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] comment: This term was made obsolete because it represents a molecular function. synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004045 [Term] id: GO:0006441 name: obsolete binding to mRNA cap namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because it represents a function rather than a process. synonym: "binding to mRNA cap" EXACT [] is_obsolete: true consider: GO:0000339 [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation relationship: regulates GO:0006413 ! translational initiation [Term] id: GO:0006447 name: regulation of translational initiation by iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] is_a: GO:0006446 ! regulation of translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation relationship: regulates GO:0006414 ! translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006450 name: regulation of translational fidelity namespace: biological_process alt_id: GO:0000029 def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] synonym: "regulation of translational accuracy" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0006451 name: translational readthrough namespace: biological_process def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg, PMID:11179232] synonym: "natural nonsense suppression" RELATED [] is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006452 name: translational frameshifting namespace: biological_process def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] xref: Wikipedia:Translational_frameshift is_a: GO:0006414 ! translational elongation [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Wikipedia:Protein_folding is_a: GO:0009987 ! cellular process [Term] id: GO:0006458 name: 'de novo' protein folding namespace: biological_process def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] synonym: "nascent chain protein folding" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0006459 name: obsolete binding unfolded ER proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "binding unfolded ER proteins" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0051082 [Term] id: GO:0006460 name: obsolete peptidyl-prolyl isomerase B reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "peptidyl-prolyl isomerase B reaction" EXACT [] is_obsolete: true consider: GO:0003755 [Term] id: GO:0006462 name: obsolete protein complex assembly, multichaperone pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. synonym: "protein complex assembly, multichaperone pathway" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051131 [Term] id: GO:0006463 name: steroid hormone receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0006464 name: cellular protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) occurring at the level of an individual cell. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "process resulting in protein modification" RELATED [] synonym: "protein modification process" BROAD [GOC:bf, GOC:jl] synonym: "protein tagging activity" RELATED [] is_a: GO:0036211 ! protein modification process is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006465 name: signal peptide processing namespace: biological_process def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] synonym: "leader peptide processing" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006466 name: obsolete protein disulfide-isomerase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it presents a molecular function. synonym: "protein disulfide-isomerase reaction" EXACT [] synonym: "protein disulphide-isomerase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003756 [Term] id: GO:0006468 name: protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid phosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0006470 name: protein dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] subset: goslim_yeast synonym: "protein amino acid dephosphorylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016311 ! dephosphorylation [Term] id: GO:0006471 name: protein ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:pr, RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] synonym: "protein amino acid ADP-ribosylation" EXACT [GOC:bf] xref: RESID:AA0040 xref: RESID:AA0168 xref: RESID:AA0169 xref: RESID:AA0231 xref: RESID:AA0237 xref: RESID:AA0295 is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0006473 name: protein acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] synonym: "protein amino acid acetylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0006474 name: N-terminal protein amino acid acetylation namespace: biological_process def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267] is_a: GO:0006473 ! protein acetylation is_a: GO:0031365 ! N-terminal protein amino acid modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] is_a: GO:0006473 ! protein acetylation [Term] id: GO:0006476 name: protein deacetylation namespace: biological_process def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] synonym: "protein amino acid deacetylation" EXACT [GOC:bf] is_a: GO:0035601 ! protein deacylation [Term] id: GO:0006477 name: protein sulfation namespace: biological_process def: "The addition of a sulfate group as an ester to a protein amino acid." [GOC:curators] synonym: "protein amino acid sulfation" EXACT [GOC:bf] synonym: "protein amino acid sulphation" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0051923 ! sulfation [Term] id: GO:0006478 name: peptidyl-tyrosine sulfation namespace: biological_process def: "The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] synonym: "peptidyl-tyrosine sulphation" EXACT [] xref: RESID:AA0172 is_a: GO:0006477 ! protein sulfation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0006479 name: protein methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] synonym: "protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0008213 ! protein alkylation is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006480 name: N-terminal protein amino acid methylation namespace: biological_process def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] is_a: GO:0006479 ! protein methylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006481 name: C-terminal protein methylation namespace: biological_process def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] synonym: "C-terminal protein amino acid methylation" EXACT [GOC:bf] is_a: GO:0006479 ! protein methylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006482 name: protein demethylation namespace: biological_process def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] synonym: "protein amino acid demethylation" EXACT [GOC:bf] is_a: GO:0008214 ! protein dealkylation is_a: GO:0070988 ! demethylation [Term] id: GO:0006483 name: obsolete peptidyl-aspartic acid/asparagine hydroxylation namespace: biological_process def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "aspartic acid/asparagine hydroxylation" EXACT [] synonym: "peptidyl-aspartic acid/asparagine hydroxylation" EXACT [] is_obsolete: true consider: GO:0042264 consider: GO:0042265 [Term] id: GO:0006484 name: obsolete protein cysteine-thiol oxidation namespace: biological_process def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] comment: This term was made obsolete because it represents a single activity. synonym: "protein cysteine-thiol oxidation" EXACT [] is_obsolete: true consider: GO:0003756 [Term] id: GO:0006486 name: protein glycosylation namespace: biological_process def: "A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [GOC:curators, GOC:pr] subset: goslim_pombe subset: goslim_yeast synonym: "protein amino acid glycosylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0043413 ! macromolecule glycosylation relationship: part_of GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006487 name: protein N-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327] synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] synonym: "protein amino acid N-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006488 name: dolichol-linked oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309] synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] synonym: "dolichol-linked oligosaccharide formation" EXACT [] synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161] synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161] synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] is_a: GO:0006490 ! oligosaccharide-lipid intermediate biosynthetic process relationship: part_of GO:0006487 ! protein N-linked glycosylation [Term] id: GO:0006489 name: dolichyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732] synonym: "dolichyl diphosphate anabolism" EXACT [] synonym: "dolichyl diphosphate biosynthesis" EXACT [] synonym: "dolichyl diphosphate formation" EXACT [] synonym: "dolichyl diphosphate synthesis" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046465 ! dolichyl diphosphate metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006490 name: oligosaccharide-lipid intermediate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an oligosaccharide-lipid intermediate, such as a molecule of dolichol-P-man or dolicol-P-Glc used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete, GOC:pr, GOC:rb] synonym: "oligosaccharide-lipid intermediate assembly" NARROW [GOC:pr] synonym: "oligosaccharide-lipid intermediate biosynthetic process" NARROW [GOC:pr] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0006491 name: N-glycan processing namespace: biological_process alt_id: GO:0006492 def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] synonym: "glycoprotein trimming involved in glycoprotein maturation" NARROW [] synonym: "N-linked glycoprotein maturation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006493 name: protein O-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [GOC:pr, ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] synonym: "protein amino acid O-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0153 xref: RESID:AA0154 xref: RESID:AA0155 xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0006494 name: obsolete protein amino acid terminal glycosylation namespace: biological_process def: "A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. synonym: "protein amino acid terminal glycosylation" EXACT [] is_obsolete: true consider: GO:0006486 [Term] id: GO:0006495 name: obsolete terminal O-glycosylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "terminal O-glycosylation" EXACT [] is_obsolete: true [Term] id: GO:0006496 name: obsolete protein amino acid terminal N-glycosylation namespace: biological_process def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] comment: This term was made obsolete because the term name is ambiguous. synonym: "protein amino acid terminal N-glycosylation" EXACT [] is_obsolete: true consider: GO:0006487 consider: GO:0035629 [Term] id: GO:0006497 name: protein lipidation namespace: biological_process alt_id: GO:0042050 def: "The covalent attachment of lipid groups to an amino acid in a protein." [GOC:jl] comment: For non-covalent interactions with a lipid, consider instead the term 'lipid binding ; GO:0008289' and its children. subset: goslim_yeast synonym: "lipid:protein modification" EXACT [] synonym: "protein amino acid lipidation" EXACT [GOC:bf] xref: RESID:AA0059 xref: RESID:AA0060 xref: RESID:AA0077 xref: RESID:AA0078 xref: RESID:AA0079 xref: RESID:AA0080 xref: RESID:AA0102 xref: RESID:AA0103 xref: RESID:AA0104 xref: RESID:AA0106 xref: RESID:AA0107 xref: RESID:AA0158 xref: RESID:AA0159 xref: RESID:AA0160 xref: RESID:AA0161 xref: RESID:AA0162 xref: RESID:AA0163 xref: RESID:AA0166 xref: RESID:AA0223 xref: RESID:AA0290 xref: RESID:AA0307 xref: RESID:AA0308 xref: RESID:AA0309 xref: RESID:AA0316 is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0042158 ! lipoprotein biosynthetic process [Term] id: GO:0006498 name: N-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the amino terminus of a protein." [GOC:jl] is_a: GO:0006497 ! protein lipidation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0006499 name: N-terminal protein myristoylation namespace: biological_process def: "The covalent attachment of a myristoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0006500 name: N-terminal protein palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0006501 name: C-terminal protein lipidation namespace: biological_process def: "The covalent attachment of a lipid group to the carboxy-terminus of a protein." [GOC:jl] is_a: GO:0006497 ! protein lipidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0006502 name: obsolete C-terminal protein prenylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl group to the carboxy-terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein prenylation" EXACT [] is_obsolete: true replaced_by: GO:0018342 [Term] id: GO:0006503 name: obsolete C-terminal protein farnesylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl group to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein farnesylation" EXACT [] is_obsolete: true replaced_by: GO:0018343 [Term] id: GO:0006504 name: obsolete C-terminal protein geranylgeranylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl group to the carboxy-terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy-terminus of a protein. synonym: "C-terminal protein geranylgeranylation" EXACT [] is_obsolete: true replaced_by: GO:0018344 [Term] id: GO:0006505 name: GPI anchor metabolic process namespace: biological_process alt_id: GO:0046472 def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate group, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732] synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] synonym: "glycosylphosphatidylinositol metabolism" EXACT [] synonym: "GPI anchor metabolism" EXACT [] synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006506 name: GPI anchor biosynthetic process namespace: biological_process alt_id: GO:0015998 def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] synonym: "GPI anchor anabolism" EXACT [] synonym: "GPI anchor biosynthesis" EXACT [] synonym: "GPI anchor formation" EXACT [] synonym: "GPI anchor synthesis" EXACT [] synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] is_a: GO:0006497 ! protein lipidation is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0006661 ! phosphatidylinositol biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process [Term] id: GO:0006507 name: GPI anchor release namespace: biological_process def: "The GPI anchor metabolic process that results in enzymatic cleavage of the anchor, releasing an anchored protein from the membrane." [GOC:mah, PMID:18811934] is_a: GO:0006505 ! GPI anchor metabolic process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds." [GOC:bf, GOC:mah] comment: This term was intentionally placed under 'protein metabolic process ; GO:0019538' rather than 'protein catabolic process ; GO:0030163' to cover all processes centered on breaking peptide bonds, including those involved in protein processing. subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006509 name: membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] synonym: "ectoderm shedding" BROAD [GOC:pm, PMID:12096138, PMID:15672459, PMID:18419754] synonym: "ectodomain cleavage" EXACT [PMID:18757500] synonym: "membrane protein solubilization" RELATED [] synonym: "receptor shedding" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0006510 name: obsolete ATP-dependent proteolysis namespace: biological_process def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] comment: This term was made obsolete because it represents a molecular function. synonym: "ATP-dependent peptidolysis" EXACT [] synonym: "ATP-dependent proteolysis" EXACT [] is_obsolete: true replaced_by: GO:0004176 consider: GO:0006508 consider: GO:0016485 consider: GO:0051603 [Term] id: GO:0006511 name: ubiquitin-dependent protein catabolic process namespace: biological_process alt_id: GO:0042787 alt_id: GO:0043432 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein." [GOC:go_curators] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] synonym: "myofibrillar protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] synonym: "protein degradation tagging activity" BROAD [] synonym: "protein ubiquitination during ubiquitin-dependent protein breakdown" NARROW [] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolic process" RELATED [GOC:dph, GOC:tb] synonym: "protein ubiquitination during ubiquitin-dependent protein catabolism" NARROW [] synonym: "protein ubiquitination during ubiquitin-dependent protein degradation" NARROW [] synonym: "protein ubiquitination involved in ubiquitin-dependent protein catabolic process" RELATED [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "protein ubiquitinylation during ubiquitin-dependent protein catabolism" NARROW [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolic process" NARROW [] synonym: "protein ubiquitylation during ubiquitin-dependent protein catabolism" NARROW [] synonym: "ubiquitin-dependent protein breakdown" EXACT [] synonym: "ubiquitin-dependent protein catabolism" EXACT [] synonym: "ubiquitin-dependent protein degradation" EXACT [] synonym: "ubiquitin-dependent proteolysis" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0006512 name: obsolete ubiquitin cycle namespace: biological_process def: "OBSOLETE. The cyclical process by which one or more ubiquitin groups are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. synonym: "ubiquitin cycle" EXACT [] is_obsolete: true [Term] id: GO:0006513 name: protein monoubiquitination namespace: biological_process def: "Addition of a single ubiquitin group to a protein." [GOC:ai] synonym: "protein monoubiquitinylation" EXACT [] synonym: "protein monoubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0006515 name: protein quality control for misfolded or incompletely synthesized proteins namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolic process" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] synonym: "protein quality control (PQC)" EXACT [] synonym: "protein quality control by the ubiquitin-proteasome system" BROAD [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0030163 ! protein catabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0006517 name: protein deglycosylation namespace: biological_process def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] synonym: "glycoprotein deglycosylation" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [CHEBI:16670, GOC:go_curators] subset: goslim_pir synonym: "peptide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process alt_id: GO:0006519 def: "The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups, as carried out by individual cells." [CHEBI:33709, GOC:curators, ISBN:0198506732] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "amino acid and derivative metabolism" EXACT [GOC:curators] synonym: "amino acid metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid and derivative metabolic process" EXACT [] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006521 name: regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] synonym: "regulation of amino acid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006522 name: alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine metabolism" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0006523 name: alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine anabolism" EXACT [] synonym: "alanine biosynthesis" EXACT [] synonym: "alanine formation" EXACT [] synonym: "alanine synthesis" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process [Term] id: GO:0006524 name: alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] synonym: "alanine breakdown" EXACT [] synonym: "alanine catabolism" EXACT [] synonym: "alanine degradation" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009080 ! pyruvate family amino acid catabolic process [Term] id: GO:0006525 name: arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] synonym: "arginine metabolism" EXACT [] xref: Wikipedia:Arginine is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006526 name: arginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, ISBN:0198506732] synonym: "arginine anabolism" EXACT [] synonym: "arginine biosynthesis" EXACT [] synonym: "arginine formation" EXACT [] synonym: "arginine synthesis" EXACT [] xref: MetaCyc:ARGININE-SYN4-PWY xref: MetaCyc:ARGSYN-PWY xref: MetaCyc:ARGSYNBSUB-PWY is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006527 name: arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:29016, GOC:go_curators] synonym: "arginine breakdown" EXACT [] synonym: "arginine catabolism" EXACT [] synonym: "arginine degradation" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006528 name: asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine metabolism" EXACT [] xref: MetaCyc:ASPARAGINESYN-PWY is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006529 name: asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine anabolism" EXACT [] synonym: "asparagine biosynthesis" EXACT [] synonym: "asparagine formation" EXACT [] synonym: "asparagine synthesis" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0006530 name: asparagine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] synonym: "asparagine breakdown" EXACT [] synonym: "asparagine catabolism" EXACT [] synonym: "asparagine degradation" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0006531 name: aspartate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate metabolism" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006532 name: aspartate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate anabolism" EXACT [] synonym: "aspartate biosynthesis" EXACT [] synonym: "aspartate formation" EXACT [] synonym: "aspartate synthesis" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0006533 name: aspartate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate breakdown" EXACT [] synonym: "aspartate catabolism" EXACT [] synonym: "aspartate degradation" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0006534 name: cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine metabolism" EXACT [] xref: Wikipedia:Cysteine_metabolism is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006535 name: cysteine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] synonym: "cysteine anabolism from serine" EXACT [] synonym: "cysteine formation from serine" EXACT [] synonym: "cysteine synthesis from serine" EXACT [] xref: MetaCyc:CYSTSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0006538 name: glutamate catabolic process namespace: biological_process alt_id: GO:0019459 def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate deamidation" RELATED [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0006539 name: glutamate catabolic process via 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] xref: MetaCyc:P162-PWY is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006540 name: glutamate decarboxylation to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] comment: Note that the third step in this pathway (conversion of succinate semialdehyde to succinate) can be catalyzed by NAD-dependent or NADP-dependent succinate semialdehyde dehydrogenase (EC:1.2.1.24 and EC:1.2.1.79, respectively). synonym: "4-aminobutyrate shunt" EXACT [] synonym: "degradation of glutamate to succinate through GABA" EXACT [MetaCyc:GLUDEG-I-PWY] synonym: "GABA shunt" EXACT [] synonym: "gamma-aminobutyrate shunt" EXACT [] synonym: "glutamate degradation via 4-aminobutyrate" EXACT [MetaCyc:GLUDEG-I-PWY] synonym: "glutamate degradation via GABA" EXACT [MetaCyc:GLUDEG-I-PWY] xref: MetaCyc:GLUDEG-I-PWY xref: MetaCyc:PWY-4321 xref: MetaCyc:PWY3O-210 is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006541 name: glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006542 name: glutamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine anabolism" EXACT [] synonym: "glutamine biosynthesis" EXACT [] synonym: "glutamine formation" EXACT [] synonym: "glutamine synthesis" EXACT [] xref: MetaCyc:GLNSYN-PWY is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006543 name: glutamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] synonym: "glutamine breakdown" EXACT [] synonym: "glutamine catabolism" EXACT [] synonym: "glutamine degradation" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006547 name: histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine metabolism" EXACT [] xref: Wikipedia:Histidine is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006548 name: histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] synonym: "histidine breakdown" EXACT [] synonym: "histidine catabolism" EXACT [] synonym: "histidine degradation" EXACT [] is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0052805 ! imidazole-containing compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006549 name: isoleucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine metabolism" EXACT [] is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006550 name: isoleucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine breakdown" EXACT [] synonym: "isoleucine catabolism" EXACT [] synonym: "isoleucine degradation" EXACT [] xref: MetaCyc:ILEUDEG-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006551 name: leucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine metabolism" EXACT [] is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006552 name: leucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine breakdown" EXACT [] synonym: "leucine catabolism" EXACT [] synonym: "leucine degradation" EXACT [] xref: MetaCyc:LEU-DEG2-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine metabolism" EXACT [] xref: Wikipedia:Lysine is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006554 name: lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine breakdown" EXACT [] synonym: "lysine catabolism" EXACT [] synonym: "lysine degradation" EXACT [] is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006555 name: methionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "methionine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006556 name: S-adenosylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732] synonym: "S-adenosyl methionine biosynthesis" EXACT [] synonym: "S-adenosyl methionine biosynthetic process" EXACT [] synonym: "S-adenosylmethionine anabolism" EXACT [] synonym: "S-adenosylmethionine biosynthesis" EXACT [] synonym: "S-adenosylmethionine formation" EXACT [] synonym: "S-adenosylmethionine synthesis" EXACT [] synonym: "SAM biosynthetic process" EXACT [] xref: MetaCyc:SAM-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0006557 name: S-adenosylmethioninamine biosynthetic process namespace: biological_process alt_id: GO:0006745 def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] synonym: "S-adenosylmethioninamine anabolism" EXACT [] synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] synonym: "S-adenosylmethioninamine formation" EXACT [] synonym: "S-adenosylmethioninamine synthesis" EXACT [] is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046129 ! purine ribonucleoside biosynthetic process is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process [Term] id: GO:0006558 name: L-phenylalanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-phenylalanine metabolism" EXACT [] synonym: "phenylalanine metabolic process" BROAD [] synonym: "phenylalanine metabolism" BROAD [] is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1902221 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process [Term] id: GO:0006559 name: L-phenylalanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] synonym: "L-phenylalanine breakdown" EXACT [] synonym: "L-phenylalanine catabolism" EXACT [] synonym: "L-phenylalanine degradation" EXACT [] synonym: "phenylalanine catabolic process" BROAD [] synonym: "phenylalanine catabolism" BROAD [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1902222 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process [Term] id: GO:0006560 name: proline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "proline metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0006561 name: proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732] synonym: "proline anabolism" EXACT [] synonym: "proline biosynthesis" EXACT [] synonym: "proline formation" EXACT [] synonym: "proline synthesis" EXACT [] xref: MetaCyc:PROSYN-PWY xref: MetaCyc:PWY-3341 is_a: GO:0006560 ! proline metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006562 name: proline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "proline breakdown" EXACT [] synonym: "proline catabolism" EXACT [] synonym: "proline degradation" EXACT [] is_a: GO:0006560 ! proline metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0006563 name: L-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] synonym: "L-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006564 name: L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] synonym: "L-serine anabolism" EXACT [] synonym: "L-serine biosynthesis" EXACT [] synonym: "L-serine formation" EXACT [] synonym: "L-serine synthesis" EXACT [] xref: MetaCyc:SERSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006565 name: L-serine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [CHEBI:17115, GOC:ai, GOC:jsg] synonym: "L-serine breakdown" EXACT [] synonym: "L-serine catabolism" EXACT [] synonym: "L-serine degradation" EXACT [] xref: MetaCyc:SERDEG-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006566 name: threonine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "threonine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006567 name: threonine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "threonine breakdown" EXACT [] synonym: "threonine catabolism" EXACT [] synonym: "threonine degradation" EXACT [] xref: MetaCyc:THREOCAT-PWY xref: UM-BBD_pathwayID:met is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006568 name: tryptophan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] synonym: "tryptophan metabolism" EXACT [] xref: Wikipedia:Tryptophan is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006569 name: tryptophan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] synonym: "tryptophan breakdown" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] synonym: "tryptophan catabolism" EXACT [] synonym: "tryptophan catabolism, using tryptophanase" NARROW [] synonym: "tryptophan degradation" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0046218 ! indolalkylamine catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006570 name: tyrosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] synonym: "tyrosine metabolism" EXACT [] xref: UM-BBD_pathwayID:tyr xref: Wikipedia:Tyrosine is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006571 name: tyrosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] synonym: "tyrosine anabolism" EXACT [] synonym: "tyrosine biosynthesis" EXACT [] synonym: "tyrosine formation" EXACT [] synonym: "tyrosine synthesis" EXACT [] xref: MetaCyc:PWY-3461 is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0006572 name: tyrosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] synonym: "tyrosine breakdown" EXACT [] synonym: "tyrosine catabolism" EXACT [] synonym: "tyrosine degradation" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006573 name: valine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine metabolism" EXACT [] is_a: GO:0009081 ! branched-chain amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006574 name: valine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine breakdown" EXACT [] synonym: "valine catabolism" EXACT [] synonym: "valine degradation" EXACT [] xref: MetaCyc:VALDEG-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009083 ! branched-chain amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006575 name: cellular modified amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [CHEBI:83821, GOC:ai] synonym: "amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolism" EXACT [GOC:mah] synonym: "modified amino acid metabolic process" EXACT [GOC:mah] synonym: "modified amino acid metabolism" EXACT [GOC:mah] is_a: GO:0044237 ! cellular metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006576 name: cellular biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] synonym: "biogenic amine metabolism" EXACT [] is_a: GO:0044106 ! cellular amine metabolic process [Term] id: GO:0006577 name: amino-acid betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine metabolic process" EXACT [] synonym: "betaine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0006578 name: amino-acid betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine anabolism" EXACT [] synonym: "betaine biosynthesis" EXACT [] synonym: "betaine biosynthetic process" EXACT [] synonym: "betaine formation" EXACT [] synonym: "betaine synthesis" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0006579 name: amino-acid betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732] synonym: "betaine breakdown" EXACT [] synonym: "betaine catabolic process" EXACT [] synonym: "betaine catabolism" EXACT [] synonym: "betaine degradation" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0006580 name: ethanolamine metabolic process namespace: biological_process alt_id: GO:0006645 def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [CHEBI:16000, GOC:jl, ISBN:01928006X] synonym: "ethanolamine metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042439 ! ethanolamine-containing compound metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0006582 name: melanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] synonym: "melanin metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0006583 name: melanin biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] synonym: "melanin anabolism from tyrosine" EXACT [] synonym: "melanin formation from tyrosine" EXACT [] synonym: "melanin synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042438 ! melanin biosynthetic process [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732] synonym: "catecholamine metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006585 name: dopamine biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "dopamine anabolism from tyrosine" EXACT [] synonym: "dopamine formation from tyrosine" EXACT [] synonym: "dopamine synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042416 ! dopamine biosynthetic process [Term] id: GO:0006586 name: indolalkylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [CHEBI:38631, GOC:curators] synonym: "indolalkylamine metabolism" EXACT [] synonym: "indolamine metabolic process" BROAD [] synonym: "indolamine metabolism" BROAD [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0006587 name: serotonin biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732] synonym: "serotonin anabolism from tryptophan" EXACT [] synonym: "serotonin formation from tryptophan" EXACT [] synonym: "serotonin synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0042427 ! serotonin biosynthetic process [Term] id: GO:0006588 name: activation of tryptophan 5-monooxygenase activity namespace: biological_process def: "The process in which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan [Term] id: GO:0006589 name: octopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepinephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732] synonym: "octopamine anabolism" EXACT [] synonym: "octopamine biosynthesis" EXACT [] synonym: "octopamine formation" EXACT [] synonym: "octopamine synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process [Term] id: GO:0006591 name: ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006592 name: ornithine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine anabolism" EXACT [] synonym: "ornithine biosynthesis" EXACT [] synonym: "ornithine formation" EXACT [] synonym: "ornithine synthesis" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0006593 name: ornithine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] synonym: "ornithine breakdown" EXACT [] synonym: "ornithine catabolism" EXACT [] synonym: "ornithine degradation" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0006595 name: polyamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0006596 name: polyamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine anabolism" EXACT [] synonym: "polyamine biosynthesis" EXACT [] synonym: "polyamine formation" EXACT [] synonym: "polyamine synthesis" EXACT [] xref: MetaCyc:POLYAMSYN-PWY is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0006597 name: spermine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [CHEBI:15746, GOC:curators] synonym: "spermine anabolism" EXACT [] synonym: "spermine biosynthesis" EXACT [] synonym: "spermine formation" EXACT [] synonym: "spermine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0006598 name: polyamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732] synonym: "polyamine breakdown" EXACT [] synonym: "polyamine catabolism" EXACT [] synonym: "polyamine degradation" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006599 name: phosphagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732] synonym: "phosphagen metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0006600 name: creatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] synonym: "creatine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006601 name: creatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [CHEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] synonym: "creatine anabolism" EXACT [] synonym: "creatine biosynthesis" EXACT [] synonym: "creatine formation" EXACT [] synonym: "creatine synthesis" EXACT [] is_a: GO:0006600 ! creatine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0006602 name: creatinine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732] synonym: "creatinine breakdown" EXACT [] synonym: "creatinine catabolism" EXACT [] synonym: "creatinine degradation" EXACT [] is_a: GO:0046449 ! creatinine metabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0006603 name: phosphocreatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [CHEBI:17287, GOC:curators, PMID:16371597] synonym: "phosphocreatine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006604 name: phosphoarginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [GOC:curators, PMID:16371597] synonym: "phosphoarginine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular regions of the cell, typically membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] comment: Note that protein targeting encompasses the transport of the protein to the specified location, and may also include additional steps such as protein processing. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe subset: goslim_yeast synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "establishment of protein localization to nucleus" EXACT [GOC:mah] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0017038 ! protein import is_a: GO:0034504 ! protein localization to nucleus is_a: GO:0051170 ! import into nucleus is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0006607 name: NLS-bearing protein import into nucleus namespace: biological_process def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear envelope." [GOC:ai] synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] synonym: "NLS-bearing substrate import into nucleus" EXACT [GOC:bf, GOC:jl] synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] synonym: "NLS-bearing substrate-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006608 name: obsolete snRNP protein import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "snRNP protein import into cell nucleus" EXACT [] synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] synonym: "snRNP protein-nucleus import" EXACT [] is_obsolete: true consider: GO:0006606 [Term] id: GO:0006609 name: obsolete mRNA-binding (hnRNP) protein import into nucleus namespace: biological_process def: "OBSOLETE. The directed movement of a heterogeneous nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] comment: The reason for obsoletion is that all proteins are imported into the nucleus via the same mechanism, so the import of individual proteins should be captured with extensions or by GO-CAM models. synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] is_obsolete: true consider: GO:0006606 [Term] id: GO:0006610 name: ribosomal protein import into nucleus namespace: biological_process def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane. At least some ribosomal proteins, including rpl12, uses the importin 11 pathway as a major route into the nucleus." [GOC:ai, PMID:11809816] comment: Ribosomal protein rpl12 uses a different import pathway, which is why it has a separate GO term. See discussion in https://github.com/geneontology/go-annotation/issues/1700. synonym: "ribosomal protein import into cell nucleus" EXACT [] synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] synonym: "ribosomal protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process alt_id: GO:0097349 def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "copper-induced protein export from nucleus" RELATED [GOC:al] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006612 name: protein targeting to membrane namespace: biological_process def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [GOC:curators] synonym: "protein membrane targeting" EXACT [] synonym: "protein-membrane targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0090150 ! establishment of protein localization to membrane [Term] id: GO:0006613 name: cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] synonym: "cotranslational membrane targeting" EXACT [] synonym: "cotranslational protein membrane targeting" EXACT [] synonym: "cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane [Term] id: GO:0006614 name: SRP-dependent cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006613 ! cotranslational protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006615 name: SRP-dependent cotranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] is_a: GO:0022615 ! protein to membrane docking relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006616 name: SRP-dependent cotranslational protein targeting to membrane, translocation namespace: biological_process def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006617 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition namespace: biological_process def: "The process in which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006618 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing namespace: biological_process def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] is_a: GO:0006465 ! signal peptide processing relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006619 name: obsolete SRP-independent cotranslational protein-membrane targeting namespace: biological_process def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "ER translocation" BROAD [] synonym: "SRP-independent cotranslational membrane targeting" EXACT [] synonym: "SRP-independent cotranslational protein-membrane targeting" EXACT [] is_obsolete: true [Term] id: GO:0006620 name: posttranslational protein targeting to endoplasmic reticulum membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] synonym: "posttranslational endoplasmic reticulum membrane targeting" EXACT [] synonym: "posttranslational endoplasmic reticulum protein-membrane targeting" EXACT [] synonym: "posttranslational protein endoplasmic reticulum membrane targeting" EXACT [] synonym: "posttranslational protein targeting to ER membrane" EXACT [] synonym: "SRP-independent endoplasmic reticulum protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006621 name: protein retention in ER lumen namespace: biological_process def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum [Term] id: GO:0006622 name: protein targeting to lysosome namespace: biological_process def: "The process of directing proteins towards the lysosome using signals contained within the protein." [GOC:curators] synonym: "protein-lysosome targeting" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0007041 ! lysosomal transport is_a: GO:0061462 ! protein localization to lysosome [Term] id: GO:0006623 name: protein targeting to vacuole namespace: biological_process def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [GOC:curators] synonym: "protein vacuolar targeting" EXACT [] synonym: "protein-vacuolar targeting" EXACT [] synonym: "protein-vacuole targeting" EXACT [] synonym: "vacuolar protein sorting" EXACT [GOC:vw] is_a: GO:0006605 ! protein targeting is_a: GO:0007034 ! vacuolar transport is_a: GO:0072666 ! establishment of protein localization to vacuole [Term] id: GO:0006624 name: vacuolar protein processing namespace: biological_process def: "Protein processing that takes place in the vacuole. Most protein processing in the vacuole represents proteolytic cleavage of precursors to form active enzymes." [GOC:mah] synonym: "vacuolar protein maturation" RELATED [] synonym: "vacuolar proteolysis" RELATED [] is_a: GO:0016485 ! protein processing is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006625 name: protein targeting to peroxisome namespace: biological_process def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] synonym: "protein-peroxisome targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0043574 ! peroxisomal transport is_a: GO:0072663 ! establishment of protein localization to peroxisome [Term] id: GO:0006626 name: protein targeting to mitochondrion namespace: biological_process alt_id: GO:0043681 def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] synonym: "mitochondrial protein import" RELATED [] synonym: "mitochondrial translocation" RELATED [] synonym: "protein import into mitochondrion" EXACT [] synonym: "protein targeting to mitochondria" EXACT [] synonym: "protein-mitochondrial targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0006839 ! mitochondrial transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0006627 name: protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] synonym: "mitochondrial processing" BROAD [] synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb] is_a: GO:0034982 ! mitochondrial protein processing relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0006628 name: obsolete mitochondrial translocation namespace: biological_process def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. synonym: "mitochondrial translocation" EXACT [] is_obsolete: true consider: GO:0006626 [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "lipid metabolism" EXACT [] xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0006630 name: obsolete lipid binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "lipid binding" EXACT [] is_obsolete: true consider: GO:0008289 [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] synonym: "fatty acid metabolism" EXACT [] xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006633 name: fatty acid biosynthetic process namespace: biological_process alt_id: GO:0000037 def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732] synonym: "fatty acid anabolism" EXACT [] synonym: "fatty acid biosynthesis" EXACT [] synonym: "fatty acid formation" EXACT [] synonym: "fatty acid synthesis" EXACT [] xref: MetaCyc:FASYN-INITIAL-PWY xref: MetaCyc:PWY-4381 xref: MetaCyc:PWY-5156 xref: Wikipedia:Fatty_acid_synthesis is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0006634 name: hexadecanal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] synonym: "hexadecanal anabolism" EXACT [] synonym: "hexadecanal biosynthesis" EXACT [] synonym: "hexadecanal formation" EXACT [] synonym: "hexadecanal synthesis" EXACT [] synonym: "palmitaldehyde biosynthesis" EXACT [] synonym: "palmitaldehyde biosynthetic process" EXACT [] is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046458 ! hexadecanal metabolic process [Term] id: GO:0006635 name: fatty acid beta-oxidation namespace: biological_process def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732, MetaCyc:FAO-PWY] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0006636 name: unsaturated fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] synonym: "fatty acid desaturation" RELATED [] synonym: "polyunsaturated fatty acid biosynthesis" NARROW [GOC:yaf, MetaCyc:PWY-762] synonym: "unsaturated fatty acid anabolism" EXACT [] synonym: "unsaturated fatty acid biosynthesis" EXACT [] synonym: "unsaturated fatty acid formation" EXACT [] synonym: "unsaturated fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006637 name: acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732] synonym: "acyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process is_a: GO:0035383 ! thioester metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006638 name: neutral lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] synonym: "neutral lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006639 name: acylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732] synonym: "acylglycerol metabolism" EXACT [] synonym: "glyceride metabolic process" EXACT [] synonym: "glyceride metabolism" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006640 name: monoacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732] synonym: "monoacylglycerol anabolism" EXACT [] synonym: "monoacylglycerol biosynthesis" EXACT [] synonym: "monoacylglycerol formation" EXACT [] synonym: "monoacylglycerol synthesis" EXACT [] synonym: "monoglyceride biosynthesis" EXACT [] synonym: "monoglyceride biosynthetic process" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006641 name: triglyceride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732] synonym: "triacylglycerol metabolic process" EXACT [] synonym: "triacylglycerol metabolism" EXACT [] synonym: "triglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0006642 name: triglyceride mobilization namespace: biological_process def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] synonym: "triacylglycerol mobilization" EXACT [] is_a: GO:0006641 ! triglyceride metabolic process [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006644 name: phospholipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006646 name: phosphatidylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] synonym: "phosphatidylethanolamine anabolism" EXACT [] synonym: "phosphatidylethanolamine biosynthesis" EXACT [] synonym: "phosphatidylethanolamine formation" EXACT [] synonym: "phosphatidylethanolamine synthesis" EXACT [] is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006647 name: phosphatidyl-N-monomethylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] synonym: "PMME biosynthesis" EXACT [] synonym: "PMME biosynthetic process" EXACT [] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process [Term] id: GO:0006648 name: dihydrosphingosine-1-P pathway namespace: biological_process def: "A phosphatidylethanolamine biosynthetic process that proceeds via the enzymatic action of dihydrosphingosine phosphate lyase." [GOC:mah, PMID:15643073] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process [Term] id: GO:0006649 name: phospholipid transfer to membrane namespace: biological_process def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] is_a: GO:0015914 ! phospholipid transport relationship: part_of GO:0061024 ! membrane organization [Term] id: GO:0006650 name: glycerophospholipid metabolic process namespace: biological_process alt_id: GO:0006652 def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732] synonym: "alpha-glycerophosphate pathway" RELATED [] synonym: "glycerophospholipid metabolism" EXACT [] synonym: "phosphoglyceride metabolic process" EXACT [] synonym: "phosphoglyceride metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006651 name: diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group." [CHEBI:18035, GOC:curators] synonym: "diacylglycerol anabolism" EXACT [] synonym: "diacylglycerol biosynthesis" EXACT [] synonym: "diacylglycerol formation" EXACT [] synonym: "diacylglycerol synthesis" EXACT [] synonym: "diglyceride biosynthesis" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006653 name: 1,2-diacyl-sn-glycero-3-phosphocholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any 1,2-diacyl-sn-glycero-3-phosphocholine, the compounds most commonly designated lecithin." [CHEBI:16110, ISBN:0198506732] synonym: "1,2-diacyl-sn-glycero-3-phosphocholine metabolism" EXACT [GOC:mah] synonym: "lecithin metabolic process" BROAD [CHEBI:16110] is_a: GO:0017144 ! drug metabolic process is_a: GO:0046470 ! phosphatidylcholine metabolic process [Term] id: GO:0006654 name: phosphatidic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732] synonym: "phosphatidic acid anabolism" EXACT [] synonym: "phosphatidic acid biosynthesis" EXACT [] synonym: "phosphatidic acid formation" EXACT [] synonym: "phosphatidic acid synthesis" EXACT [] is_a: GO:0046473 ! phosphatidic acid metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006655 name: phosphatidylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732] synonym: "phosphatidylglycerol anabolism" EXACT [] synonym: "phosphatidylglycerol biosynthesis" EXACT [] synonym: "phosphatidylglycerol formation" EXACT [] synonym: "phosphatidylglycerol synthesis" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006656 name: phosphatidylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732] synonym: "phosphatidylcholine anabolism" EXACT [] synonym: "phosphatidylcholine biosynthesis" EXACT [] synonym: "phosphatidylcholine formation" EXACT [] synonym: "phosphatidylcholine synthesis" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006657 name: CDP-choline pathway namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309, MetaCyc:PWY3O-450] synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450] synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450] xref: MetaCyc:PWY3O-450 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0006658 name: phosphatidylserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732] synonym: "phosphatidylserine metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0006659 name: phosphatidylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] synonym: "phosphatidylserine anabolism" EXACT [] synonym: "phosphatidylserine biosynthesis" EXACT [] synonym: "phosphatidylserine formation" EXACT [] synonym: "phosphatidylserine synthesis" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006660 name: phosphatidylserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732] synonym: "phosphatidylserine breakdown" EXACT [] synonym: "phosphatidylserine catabolism" EXACT [] synonym: "phosphatidylserine degradation" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0006661 name: phosphatidylinositol biosynthetic process namespace: biological_process alt_id: GO:0046489 def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [CHEBI:28874, ISBN:0198506732] synonym: "phosphatidylinositol anabolism" EXACT [] synonym: "phosphatidylinositol biosynthesis" EXACT [] synonym: "phosphatidylinositol formation" EXACT [] synonym: "phosphatidylinositol synthesis" EXACT [] synonym: "phosphoinositide biosynthesis" EXACT [] synonym: "phosphoinositide biosynthetic process" EXACT [] synonym: "PtdIns biosynthesis" EXACT [] synonym: "PtdIns biosynthetic process" EXACT [] is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0006662 name: glycerol ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "glycerol ether metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0006663 name: platelet activating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF biosynthesis" EXACT [] synonym: "PAF biosynthetic process" EXACT [] synonym: "platelet activating factor anabolism" EXACT [] synonym: "platelet activating factor biosynthesis" EXACT [] synonym: "platelet activating factor formation" EXACT [] synonym: "platelet activating factor synthesis" EXACT [] is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006664 name: glycolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar group acylated by one or more fatty acids and the glycerol group may be absent." [CHEBI:33563, ISBN:0198547684] synonym: "glycolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:1903509 ! liposaccharide metabolic process [Term] id: GO:0006665 name: sphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006666 name: 3-keto-sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] synonym: "3-keto-sphinganine metabolism" EXACT [] is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006667 name: sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18] synonym: "dihydrosphingosine metabolic process" EXACT [] synonym: "dihydrosphingosine metabolism" EXACT [] synonym: "sphinganine metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006668 name: sphinganine-1-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] synonym: "sphinganine-1-phosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006669 name: sphinganine-1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] synonym: "sphinganine-1-phosphate anabolism" EXACT [] synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] synonym: "sphinganine-1-phosphate formation" EXACT [] synonym: "sphinganine-1-phosphate synthesis" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006670 name: sphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732] synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] synonym: "(4E)-sphing-4-enine metabolism" EXACT [] synonym: "sphing-4-enine metabolic process" EXACT [] synonym: "sphing-4-enine metabolism" EXACT [] synonym: "sphingosine metabolism" EXACT [] is_a: GO:0034311 ! diol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006671 name: phytosphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [CHEBI:46961, ISBN:0198506732] synonym: "phytosphingosine metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006672 name: ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] synonym: "ceramide metabolism" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006673 name: inositol phosphoceramide metabolic process namespace: biological_process alt_id: GO:0006674 def: "The chemical reactions and pathways involving inositol phosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] synonym: "inositol phosphorylceramide metabolic process" EXACT [] synonym: "inositol phosphorylceramide metabolism" EXACT [] synonym: "inositolphosphoceramide metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006675 name: mannosyl-inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] synonym: "mannose inositol phosphoceramide metabolic process" EXACT [] synonym: "mannose inositol phosphoceramide metabolism" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] synonym: "MIPC metabolic process" EXACT [] synonym: "MIPC metabolism" EXACT [] is_a: GO:0006673 ! inositol phosphoceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006676 name: mannosyl diphosphorylinositol ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide group which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] synonym: "M(IP)2C metabolic process" EXACT [] synonym: "M(IP)2C metabolism" EXACT [] synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0006673 ! inositol phosphoceramide metabolic process [Term] id: GO:0006677 name: glycosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732] synonym: "glycosylceramide metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006678 name: glucosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [CHEBI:36500, GOC:curators, ISBN:0198506732] synonym: "glucosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process [Term] id: GO:0006679 name: glucosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] synonym: "glucosylceramide anabolism" EXACT [] synonym: "glucosylceramide biosynthesis" EXACT [] synonym: "glucosylceramide formation" EXACT [] synonym: "glucosylceramide synthesis" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006680 name: glucosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] synonym: "glucosylceramide breakdown" EXACT [] synonym: "glucosylceramide catabolism" EXACT [] synonym: "glucosylceramide degradation" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046477 ! glycosylceramide catabolic process [Term] id: GO:0006681 name: galactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0006682 name: galactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide anabolism" EXACT [] synonym: "galactosylceramide biosynthesis" EXACT [] synonym: "galactosylceramide formation" EXACT [] synonym: "galactosylceramide synthesis" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019375 ! galactolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006683 name: galactosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] synonym: "galactosylceramide breakdown" EXACT [] synonym: "galactosylceramide catabolism" EXACT [] synonym: "galactosylceramide degradation" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019376 ! galactolipid catabolic process is_a: GO:0046477 ! glycosylceramide catabolic process [Term] id: GO:0006684 name: sphingomyelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0006685 name: sphingomyelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin breakdown" EXACT [] synonym: "sphingomyelin catabolism" EXACT [] synonym: "sphingomyelin degradation" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0006686 name: sphingomyelin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732] synonym: "sphingomyelin anabolism" EXACT [] synonym: "sphingomyelin biosynthesis" EXACT [] synonym: "sphingomyelin formation" EXACT [] synonym: "sphingomyelin synthesis" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0006687 name: glycosphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] synonym: "glycosphingolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006688 name: glycosphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] synonym: "glycosphingolipid anabolism" EXACT [] synonym: "glycosphingolipid biosynthesis" EXACT [] synonym: "glycosphingolipid formation" EXACT [] synonym: "glycosphingolipid synthesis" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006689 name: ganglioside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] synonym: "ganglioside breakdown" EXACT [] synonym: "ganglioside catabolism" EXACT [] synonym: "ganglioside degradation" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process is_a: GO:0046514 ! ceramide catabolic process [Term] id: GO:0006690 name: icosanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] synonym: "eicosanoid metabolic process" EXACT [] synonym: "eicosanoid metabolism" EXACT [] synonym: "icosanoid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:1901568 ! fatty acid derivative metabolic process [Term] id: GO:0006691 name: leukotriene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] synonym: "leukotriene metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0006692 name: prostanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732] synonym: "prostanoid metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006693 name: prostaglandin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732] synonym: "prostaglandin metabolism" EXACT [] is_a: GO:0006692 ! prostanoid metabolic process [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006695 name: cholesterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol anabolism" EXACT [] synonym: "cholesterol biosynthesis" EXACT [] synonym: "cholesterol formation" EXACT [] synonym: "cholesterol synthesis" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006696 name: ergosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732] synonym: "ergosterol anabolism" EXACT [] synonym: "ergosterol biosynthesis" EXACT [] synonym: "ergosterol formation" EXACT [] synonym: "ergosterol synthesis" EXACT [] is_a: GO:0008204 ! ergosterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0044108 ! cellular alcohol biosynthetic process is_a: GO:0097384 ! cellular lipid biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006697 name: ecdysone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] synonym: "ecdysone anabolism" EXACT [] synonym: "ecdysone biosynthesis" EXACT [] synonym: "ecdysone formation" EXACT [] synonym: "ecdysone synthesis" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0045456 ! ecdysteroid biosynthetic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0006698 name: obsolete ecdysone modification namespace: biological_process def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. synonym: "ecdysone modification" EXACT [] is_obsolete: true replaced_by: GO:0004501 [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0006700 name: C21-steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone anabolism" EXACT [] synonym: "C21-steroid hormone biosynthesis" EXACT [] synonym: "C21-steroid hormone formation" EXACT [] synonym: "C21-steroid hormone synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006701 name: progesterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone anabolism" EXACT [] synonym: "progesterone biosynthesis" EXACT [] synonym: "progesterone formation" EXACT [] synonym: "progesterone synthesis" EXACT [] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006702 name: androgen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen anabolism" EXACT [] synonym: "androgen biosynthesis" EXACT [] synonym: "androgen formation" EXACT [] synonym: "androgen synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006703 name: estrogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen anabolism" EXACT [] synonym: "estrogen biosynthesis" EXACT [] synonym: "estrogen formation" EXACT [] synonym: "estrogen synthesis" EXACT [] synonym: "oestrogen biosynthesis" EXACT [] synonym: "oestrogen biosynthetic process" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006704 name: glucocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006705 name: mineralocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid anabolism" EXACT [] synonym: "mineralocorticoid biosynthesis" EXACT [] synonym: "mineralocorticoid formation" EXACT [] synonym: "mineralocorticoid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0006707 name: cholesterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol breakdown" EXACT [] synonym: "cholesterol catabolism" EXACT [] synonym: "cholesterol degradation" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0006708 name: ecdysone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732] synonym: "ecdysone breakdown" EXACT [] synonym: "ecdysone catabolism" EXACT [] synonym: "ecdysone degradation" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046344 ! ecdysteroid catabolic process [Term] id: GO:0006709 name: progesterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone breakdown" EXACT [] synonym: "progesterone catabolism" EXACT [] synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0042448 ! progesterone metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0006710 name: androgen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen breakdown" EXACT [] synonym: "androgen catabolism" EXACT [] synonym: "androgen degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006711 name: estrogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen breakdown" EXACT [] synonym: "estrogen catabolism" EXACT [] synonym: "estrogen degradation" EXACT [] synonym: "oestrogen catabolic process" EXACT [] synonym: "oestrogen catabolism" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006712 name: mineralocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "mineralocorticoid breakdown" EXACT [] synonym: "mineralocorticoid catabolism" EXACT [] synonym: "mineralocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006713 name: glucocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732] synonym: "glucocorticoid breakdown" EXACT [] synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006715 name: farnesol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] synonym: "farnesol anabolism" EXACT [] synonym: "farnesol biosynthesis" EXACT [] synonym: "farnesol formation" EXACT [] synonym: "farnesol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0034309 ! primary alcohol biosynthetic process [Term] id: GO:0006716 name: juvenile hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0006717 name: obsolete juvenile hormone binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "juvenile hormone binding" EXACT [] is_obsolete: true consider: GO:0005500 [Term] id: GO:0006718 name: juvenile hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone anabolism" EXACT [] synonym: "juvenile hormone biosynthesis" EXACT [] synonym: "juvenile hormone formation" EXACT [] synonym: "juvenile hormone synthesis" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006719 name: juvenile hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone breakdown" EXACT [] synonym: "juvenile hormone catabolism" EXACT [] synonym: "juvenile hormone degradation" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732] synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0006722 name: triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] synonym: "triterpene metabolic process" NARROW [] synonym: "triterpene metabolism" NARROW [] synonym: "triterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006723 name: cuticle hydrocarbon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] synonym: "cuticle hydrocarbon anabolism" EXACT [] synonym: "cuticle hydrocarbon biosynthesis" EXACT [] synonym: "cuticle hydrocarbon formation" EXACT [] synonym: "cuticle hydrocarbon synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006726 name: eye pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment anabolism" EXACT [] synonym: "eye pigment biosynthesis" EXACT [] synonym: "eye pigment formation" EXACT [] synonym: "eye pigment synthesis" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006727 name: ommochrome biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732] synonym: "ommochrome anabolism" EXACT [] synonym: "ommochrome biosynthesis" EXACT [] synonym: "ommochrome formation" EXACT [] synonym: "ommochrome synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0008055 ! ocellus pigment biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046152 ! ommochrome metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0006728 name: pteridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] synonym: "pteridine anabolism" EXACT [] synonym: "pteridine biosynthesis" EXACT [] synonym: "pteridine formation" EXACT [] synonym: "pteridine synthesis" EXACT [] synonym: "pterin biosynthesis" NARROW [] synonym: "pterin biosynthetic process" NARROW [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006729 name: tetrahydrobiopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [CHEBI:15372, GOC:go_curators, ISBN:0198506732] synonym: "5,6,7,8-tetrahydrobiopterin biosynthetic process" EXACT [CHEBI:15372, GOC:curators] synonym: "tetrahydrobiopterin anabolism" EXACT [] synonym: "tetrahydrobiopterin biosynthesis" EXACT [] synonym: "tetrahydrobiopterin formation" EXACT [] synonym: "tetrahydrobiopterin synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0034312 ! diol biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0006730 name: one-carbon metabolic process namespace: biological_process alt_id: GO:0019753 alt_id: GO:0019754 def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] subset: goslim_pir synonym: "one carbon metabolic process" EXACT [GOC:mah] synonym: "one carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah] synonym: "one-carbon transfer metabolism" EXACT [GOC:mah] xref: UM-BBD_pathwayID:C1cyc is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006731 name: obsolete coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0006732 consider: GO:0051189 [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process alt_id: GO:0006752 def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732] synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] synonym: "group transfer coenzyme metabolic process" NARROW [] synonym: "group transfer coenzyme metabolism" NARROW [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006733 name: oxidoreduction coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] synonym: "oxidoreduction coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006734 name: NADH metabolic process namespace: biological_process def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] synonym: "NAD (reduced) metabolic process" EXACT [] synonym: "NAD (reduced) metabolism" EXACT [] synonym: "NADH metabolism" EXACT [] synonym: "reduced NAD metabolic process" EXACT [] synonym: "reduced NAD metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006735 name: NADH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADH by the reduction of NAD+." [GOC:mah] synonym: "NAD (reduced) regeneration" EXACT [] synonym: "reduced NAD regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019674 ! NAD metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006738 name: nicotinamide riboside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732] synonym: "N-ribosylnicotinamide catabolic process" EXACT [CHEBI:15927] synonym: "nicotinamide riboside breakdown" EXACT [] synonym: "nicotinamide riboside catabolism" EXACT [] synonym: "nicotinamide riboside degradation" EXACT [] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0070638 ! pyridine nucleoside catabolic process [Term] id: GO:0006739 name: NADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NAD phosphorylation and dephosphorylation" RELATED [] synonym: "NADP (oxidized) metabolic process" EXACT [] synonym: "NADP (oxidized) metabolism" EXACT [] synonym: "NADP (reduced) metabolic process" EXACT [] synonym: "NADP (reduced) metabolism" EXACT [] synonym: "NADP metabolism" EXACT [] synonym: "NADPH metabolic process" EXACT [] synonym: "NADPH metabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "oxidized NADP metabolic process" EXACT [] synonym: "oxidized NADP metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "reduced NADP metabolic process" EXACT [] synonym: "reduced NADP metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006740 name: NADPH regeneration namespace: biological_process def: "A metabolic process that generates a pool of NADPH by the reduction of NADP+." [GOC:mah] synonym: "NADP (reduced) regeneration" EXACT [] synonym: "reduced NADP regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006739 ! NADP metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0006741 name: NADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NADP (oxidized) biosynthesis" EXACT [] synonym: "NADP (oxidized) biosynthetic process" EXACT [] synonym: "NADP (reduced) biosynthesis" EXACT [] synonym: "NADP (reduced) biosynthetic process" EXACT [] synonym: "NADP anabolism" EXACT [] synonym: "NADP biosynthesis" EXACT [] synonym: "NADP formation" EXACT [] synonym: "NADP synthesis" EXACT [] synonym: "NADPH biosynthesis" EXACT [] synonym: "NADPH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "oxidized NADP biosynthesis" EXACT [] synonym: "oxidized NADP biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "reduced NADP biosynthesis" EXACT [] synonym: "reduced NADP biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0006742 name: NADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] synonym: "NADP (oxidized) catabolic process" EXACT [] synonym: "NADP (oxidized) catabolism" EXACT [] synonym: "NADP (reduced) catabolic process" EXACT [] synonym: "NADP (reduced) catabolism" EXACT [] synonym: "NADP breakdown" EXACT [] synonym: "NADP catabolism" EXACT [] synonym: "NADP degradation" EXACT [] synonym: "NADPH catabolic process" EXACT [] synonym: "NADPH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "oxidized NADP catabolic process" EXACT [] synonym: "oxidized NADP catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "reduced NADP catabolic process" EXACT [] synonym: "reduced NADP catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019364 ! pyridine nucleotide catabolic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0006743 name: ubiquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "coenzyme Q metabolic process" EXACT [] synonym: "coenzyme Q metabolism" EXACT [] synonym: "ubiquinone metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:1901661 ! quinone metabolic process [Term] id: GO:0006744 name: ubiquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "coenzyme Q biosynthetic process" EXACT [] synonym: "coenzyme Q10 biosynthesis" NARROW [] synonym: "coenzyme Q10 biosynthetic process" NARROW [] synonym: "coenzyme Q6 biosynthesis" NARROW [] synonym: "coenzyme Q6 biosynthetic process" NARROW [] synonym: "coenzyme Q8 biosynthesis" NARROW [] synonym: "coenzyme Q8 biosynthetic process" NARROW [] synonym: "coenzyme Q9 biosynthesis" NARROW [] synonym: "coenzyme Q9 biosynthetic process" NARROW [] synonym: "ubiquinone anabolism" EXACT [] synonym: "ubiquinone biosynthesis" EXACT [] synonym: "ubiquinone formation" EXACT [] synonym: "ubiquinone synthesis" EXACT [] xref: MetaCyc:UBISYN-PWY is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0006746 name: FADH2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the reduced form of flavin adenine dinucleotide." [CHEBI:17877, GOC:ai] synonym: "FADH2 metabolism" EXACT [] synonym: "reduced flavin adenine dinucleotide metabolic process" EXACT [GOC:mah] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0072387 ! flavin adenine dinucleotide metabolic process [Term] id: GO:0006747 name: FAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:ai, ISBN:0198506732] synonym: "FAD anabolism" EXACT [] synonym: "FAD biosynthesis" EXACT [] synonym: "FAD formation" EXACT [] synonym: "FAD synthesis" EXACT [] synonym: "oxidized flavin adenine dinucleotide biosynthesis" EXACT [GOC:curators] synonym: "oxidized flavin adenine dinucleotide biosynthetic process" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide biosynthesis" EXACT [GOC:curators] synonym: "oxidized flavin-adenine dinucleotide biosynthetic process" EXACT [GOC:curators] is_a: GO:0046443 ! FAD metabolic process is_a: GO:0072388 ! flavin adenine dinucleotide biosynthetic process [Term] id: GO:0006748 name: lipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [CHEBI:17460, GOC:go_curators] synonym: "lipoamide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006749 name: glutathione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [CHEBI:16856, ISBN:0198506732] synonym: "glutathione metabolism" EXACT [] synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006750 name: glutathione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, GOC:al, GOC:pde, ISBN:0198506732] synonym: "glutathione anabolism" EXACT [] synonym: "glutathione biosynthesis" EXACT [] synonym: "glutathione formation" EXACT [] synonym: "glutathione synthesis" EXACT [] xref: MetaCyc:GLUTATHIONESYN-PWY is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006751 name: glutathione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [CHEBI:16856, GOC:ai, ISBN:0198506732] synonym: "glutathione breakdown" EXACT [] synonym: "glutathione catabolism" EXACT [] synonym: "glutathione degradation" EXACT [] is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 alt_id: GO:0006759 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732] synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP regeneration" NARROW [] synonym: "ATP synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006755 name: obsolete carbamoyl phosphate-ADP transphosphorylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). synonym: "carbamoyl phosphate-ADP transphosphorylation" EXACT [] is_obsolete: true [Term] id: GO:0006756 name: AMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046033 ! AMP metabolic process is_a: GO:0046940 ! nucleoside monophosphate phosphorylation [Term] id: GO:0006757 name: ATP generation from ADP namespace: biological_process def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] synonym: "ADP phosphorylation" EXACT [GOC:dph] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0046031 ! ADP metabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006760 name: folic acid-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units." [CHEBI:37445, GOC:ai, GOC:mah] synonym: "folate and derivative metabolic process" EXACT [] synonym: "folate and derivative metabolism" EXACT [] synonym: "folate-containing compound metabolic process" EXACT [GOC:curators] synonym: "folate-containing compound metabolism" EXACT [GOC:curators] synonym: "folic acid and derivative metabolic process" EXACT [GOC:curators] synonym: "folic acid and derivative metabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound metabolism" EXACT [GOC:curators] synonym: "vitamin B9 and derivative metabolic process" EXACT [] synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042558 ! pteridine-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006761 name: dihydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] synonym: "7,8-dihydrofolate biosynthesis" EXACT [] synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] synonym: "dihydrofolate anabolism" EXACT [] synonym: "dihydrofolate biosynthesis" EXACT [] synonym: "dihydrofolate formation" EXACT [] synonym: "dihydrofolate synthesis" EXACT [] is_a: GO:0009396 ! folic acid-containing compound biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046452 ! dihydrofolate metabolic process [Term] id: GO:0006762 name: obsolete dihydrofolate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "dihydrofolate reduction" EXACT [] is_obsolete: true consider: GO:0004146 consider: GO:0046452 [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vitamin metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006767 name: water-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] synonym: "water-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006768 name: biotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732] synonym: "biotin metabolism" EXACT [] synonym: "vitamin B7 metabolic process" EXACT [] synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Wikipedia:Biotin is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0006769 name: nicotinamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732] synonym: "niacin metabolic process" RELATED [] synonym: "niacin metabolism" RELATED [] synonym: "nicotinamide metabolism" EXACT [] synonym: "vitamin B3 metabolic process" BROAD [] synonym: "vitamin B3 metabolism" BROAD [] xref: MetaCyc:PWY-5083 is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0006771 name: riboflavin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin metabolism" EXACT [] synonym: "vitamin B2 metabolic process" EXACT [] synonym: "vitamin B2 metabolism" EXACT [] synonym: "vitamin G metabolic process" EXACT [] synonym: "vitamin G metabolism" EXACT [] xref: Wikipedia:Riboflavin is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042726 ! flavin-containing compound metabolic process [Term] id: GO:0006772 name: thiamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] synonym: "thiamin metabolic process" EXACT [GOC:curators] synonym: "thiamin metabolism" EXACT [] synonym: "thiamine metabolism" EXACT [] synonym: "vitamin B1 metabolic process" EXACT [] synonym: "vitamin B1 metabolism" EXACT [] xref: Wikipedia:Thiamine is_a: GO:0042723 ! thiamine-containing compound metabolic process [Term] id: GO:0006774 name: obsolete vitamin B12 reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "vitamin B12 reduction" EXACT [] is_obsolete: true consider: GO:0009235 consider: GO:0050453 [Term] id: GO:0006775 name: fat-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732] synonym: "fat-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006776 name: vitamin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "vitamin A metabolism" EXACT [] is_a: GO:0001523 ! retinoid metabolic process is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0006777 name: Mo-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257, PMID:22370186, PMID:23201473] synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] synonym: "Mo-molybdopterin cofactor formation" EXACT [] synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] synonym: "Moco biosynthesis" EXACT [] synonym: "Moco biosynthetic process" EXACT [] synonym: "molybdenum cofactor biosynthetic process" RELATED [] xref: MetaCyc:PWY-6823 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0006778 name: porphyrin-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin metabolic process" RELATED [] synonym: "porphyrin metabolism" RELATED [] xref: Wikipedia:Porphyrin is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006779 name: porphyrin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin anabolism" RELATED [] synonym: "porphyrin biosynthesis" RELATED [] synonym: "porphyrin biosynthetic process" RELATED [] synonym: "porphyrin formation" RELATED [] synonym: "porphyrin synthesis" RELATED [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006780 name: uroporphyrinogen III biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] synonym: "uroporphyrinogen III anabolism" EXACT [] synonym: "uroporphyrinogen III biosynthesis" EXACT [] synonym: "uroporphyrinogen III formation" EXACT [] synonym: "uroporphyrinogen III synthesis" EXACT [] is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046502 ! uroporphyrinogen III metabolic process [Term] id: GO:0006781 name: succinyl-CoA pathway namespace: biological_process def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "succinyl CoA pathway" EXACT [] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process [Term] id: GO:0006782 name: protoporphyrinogen IX biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism" EXACT [] synonym: "protoporphyrinogen IX biosynthesis" EXACT [] synonym: "protoporphyrinogen IX formation" EXACT [] synonym: "protoporphyrinogen IX synthesis" EXACT [] is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0046501 ! protoporphyrinogen IX metabolic process relationship: part_of GO:0006783 ! heme biosynthetic process [Term] id: GO:0006783 name: heme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] synonym: "haem biosynthesis" EXACT [] synonym: "haem biosynthetic process" EXACT [] synonym: "heme anabolism" EXACT [] synonym: "heme biosynthesis" EXACT [] synonym: "heme formation" EXACT [] synonym: "heme synthesis" EXACT [] xref: MetaCyc:HEMESYN2-PWY is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006784 name: heme a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [CHEBI:24479, GOC:ai] synonym: "haem a biosynthesis" EXACT [] synonym: "haem a biosynthetic process" EXACT [] synonym: "heme a anabolism" EXACT [] synonym: "heme a biosynthesis" EXACT [] synonym: "heme a formation" EXACT [] synonym: "heme a synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0006785 name: heme b biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [GOC:yaf, http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25, UniPathway:UPA00252] synonym: "haem b biosynthesis" EXACT [] synonym: "haem b biosynthetic process" EXACT [] synonym: "heme b anabolism" EXACT [] synonym: "heme b biosynthesis" EXACT [] synonym: "heme b formation" EXACT [] synonym: "heme b synthesis" EXACT [] synonym: "protoheme biosynthesis" EXACT [] synonym: "protoheme biosynthetic process" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046492 ! heme b metabolic process [Term] id: GO:0006786 name: heme c biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [GOC:curators, PubChem_Compound:122208] synonym: "haem c biosynthesis" EXACT [] synonym: "haem c biosynthetic process" EXACT [] synonym: "heme c anabolism" EXACT [] synonym: "heme c biosynthesis" EXACT [] synonym: "heme c formation" EXACT [] synonym: "heme c synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0006787 name: porphyrin-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732] synonym: "porphyrin breakdown" RELATED [] synonym: "porphyrin catabolic process" RELATED [] synonym: "porphyrin catabolism" RELATED [] synonym: "porphyrin degradation" RELATED [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006788 name: heme oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] synonym: "haem oxidation" EXACT [] is_a: GO:0042168 ! heme metabolic process is_a: GO:0055114 ! oxidation-reduction process relationship: part_of GO:0006787 ! porphyrin-containing compound catabolic process [Term] id: GO:0006789 name: bilirubin conjugation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bilirubin monoglucuronide or bilirubin diglucuronide, water-soluble derivatives of bilirubin." [DOI:10.1016/0305-0491(80)90243-6] is_a: GO:0006787 ! porphyrin-containing compound catabolic process [Term] id: GO:0006790 name: sulfur compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006791 name: sulfur utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] synonym: "sulphur utilization" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0006792 name: regulation of sulfur utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] synonym: "regulation of sulphur utilization" EXACT [] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0006791 ! sulfur utilization [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006794 name: phosphorus utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process [Term] id: GO:0006795 name: regulation of phosphorus utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0006796 name: phosphate-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] synonym: "phosphate metabolic process" RELATED [] synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006797 name: polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] synonym: "polyphosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0006798 name: polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732] synonym: "polyphosphate breakdown" EXACT [] synonym: "polyphosphate catabolism" EXACT [] synonym: "polyphosphate degradation" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0006799 name: polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732] synonym: "polyphosphate anabolism" EXACT [] synonym: "polyphosphate biosynthesis" EXACT [] synonym: "polyphosphate formation" EXACT [] synonym: "polyphosphate synthesis" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0006800 name: obsolete oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "oxygen and active oxygen species metabolism" EXACT [] synonym: "oxygen and AOS metabolism" EXACT [] synonym: "oxygen and reactive oxidative species metabolism" EXACT [] synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] synonym: "oxygen and reactive oxygen species metabolic process" EXACT [] synonym: "oxygen and reactive oxygen species metabolism" EXACT [] synonym: "oxygen and ROI metabolism" EXACT [] synonym: "oxygen and ROS metabolic process" EXACT [] synonym: "oxygen and ROS metabolism" EXACT [] is_obsolete: true consider: GO:0072592 consider: GO:0072593 [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [CHEBI:18421, GOC:jl] synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] is_a: GO:0072593 ! reactive oxygen species metabolic process [Term] id: GO:0006802 name: obsolete catalase reaction namespace: biological_process def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] comment: This term was made obsolete because it represents a molecular function. synonym: "catalase reaction" EXACT [] synonym: "hydroperoxidase reaction" RELATED [] is_obsolete: true consider: GO:0004096 [Term] id: GO:0006803 name: obsolete glutathione conjugation reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "glutathione conjugation reaction" EXACT [] is_obsolete: true replaced_by: GO:0004364 [Term] id: GO:0006804 name: obsolete peroxidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "peroxidase reaction" EXACT [] is_obsolete: true replaced_by: GO:0004601 [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "xenobiotic metabolism" EXACT [] xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus [Term] id: GO:0006806 name: obsolete insecticide resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "insecticide resistance" EXACT [] is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen." [CHEBI:51143, GOC:go_curators, GOC:jl, ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006808 name: regulation of nitrogen utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0006809 name: nitric oxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process is_a: GO:1903409 ! reactive oxygen species biosynthetic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 alt_id: GO:0044765 def: "The directed movement of substances (such as macromolecules, small molecules, ions) or cellular components (such as complexes and organelles) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter, pore or motor protein." [GOC:dos, GOC:dph, GOC:jl, GOC:mah] comment: Note that this term should not be used for direct annotation. It should be possible to make a more specific annotation to one of the children of this term, for e.g. to transmembrane transport, to microtubule-based transport or to vesicle-mediated transport. subset: gocheck_do_not_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "single-organism transport" RELATED [] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast is_a: GO:0006810 ! transport [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 alt_id: GO:0015674 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "di-, tri-valent inorganic cation transport" NARROW [GOC:mah] is_a: GO:0006811 ! ion transport [Term] id: GO:0006813 name: potassium ion transport namespace: biological_process alt_id: GO:0015458 alt_id: GO:0071804 def: "The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cellular potassium ion transport" EXACT [] synonym: "K+ conductance" RELATED [] synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "potassium conductance" NARROW [] synonym: "potassium ion conductance" NARROW [] synonym: "potassium transport" RELATED [] synonym: "sodium/potassium transport" BROAD [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006815 name: obsolete sodium/potassium transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "sodium/potassium transport" EXACT [] is_obsolete: true consider: GO:0006813 consider: GO:0006814 [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006817 name: phosphate ion transport namespace: biological_process def: "The directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "phosphate transport" RELATED [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006811 ! ion transport [Term] id: GO:0006821 name: chloride transport namespace: biological_process def: "The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006823 name: obsolete heavy metal ion transport namespace: biological_process def: "OBSOLETE. The directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal ion transport" EXACT [] is_obsolete: true consider: GO:0030001 [Term] id: GO:0006824 name: cobalt ion transport namespace: biological_process def: "The directed movement of cobalt (Co) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cobalt transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport [Term] id: GO:0006825 name: copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006826 name: iron ion transport namespace: biological_process alt_id: GO:0015681 alt_id: GO:0015682 alt_id: GO:0015684 alt_id: GO:0033216 alt_id: GO:0097286 def: "The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "ferric ion import" NARROW [] synonym: "ferric ion transport" NARROW [] synonym: "ferric iron import" NARROW [] synonym: "ferric iron transport" NARROW [] synonym: "ferric iron uptake" NARROW [] synonym: "ferrous ion transport" NARROW [] synonym: "ferrous iron transport" NARROW [] synonym: "iron ion import" RELATED [] synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006828 name: manganese ion transport namespace: biological_process def: "The directed movement of manganese (Mn) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006829 name: zinc ion transport namespace: biological_process def: "The directed movement of zinc (Zn II) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "zinc II ion transport" EXACT [] synonym: "zinc transport" EXACT [GOC:mah] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006832 name: obsolete small molecule transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "small molecule transport" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0006833 name: water transport namespace: biological_process def: "The directed movement of water (H2O) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0042044 ! fluid transport [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015844 ! monoamine transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0006838 name: obsolete allantoin/allantoate transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. synonym: "allantoin/allantoate transport" EXACT [] is_obsolete: true consider: GO:0015719 consider: GO:0015720 [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] synonym: "mitochondrial aspartate/glutamate transport" NARROW [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0006840 name: obsolete mitochondrial alpha-ketoglutarate/malate transport namespace: biological_process def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial alpha-ketoglutarate/malate transport" EXACT [] synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] is_obsolete: true consider: GO:0006839 consider: GO:0015367 consider: GO:0015742 consider: GO:0015743 [Term] id: GO:0006842 name: tricarboxylic acid transport namespace: biological_process def: "The directed movement of tricarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006843 name: mitochondrial citrate transmembrane transport namespace: biological_process alt_id: GO:1990541 def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into or out of a mitochondrial matrix." [GOC:ai, PMID:20371607] synonym: "mitochondrial citrate transport" RELATED [] is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015746 ! citrate transport is_a: GO:1990546 ! mitochondrial tricarboxylic acid transmembrane transport [Term] id: GO:0006844 name: acyl carnitine transport namespace: biological_process def: "The directed movement of acyl carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0006845 name: obsolete mitochondrial aspartate/glutamate transport namespace: biological_process def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial aspartate/glutamate transport" EXACT [] is_obsolete: true consider: GO:0006839 consider: GO:0015810 consider: GO:0015813 [Term] id: GO:0006846 name: acetate transport namespace: biological_process def: "The directed movement of acetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0006847 name: plasma membrane acetate transport namespace: biological_process def: "The directed movement of acetate across a plasma membrane." [GOC:ai] is_a: GO:0035433 ! acetate transmembrane transport [Term] id: GO:0006848 name: pyruvate transport namespace: biological_process def: "The directed movement of pyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006849 name: plasma membrane pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] is_a: GO:1901475 ! pyruvate transmembrane transport [Term] id: GO:0006850 name: mitochondrial pyruvate transmembrane transport namespace: biological_process alt_id: GO:1902361 def: "The process in which pyruvate is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:vw, PMID:22628558] synonym: "mitochondrial pyruvate transport" RELATED [] synonym: "pyruvate membrane transport in mitochondria" RELATED [] synonym: "pyruvate membrane transport in mitochondrion" RELATED [] synonym: "pyruvate transmembrane transport in mitochondria" RELATED [] synonym: "pyruvate transmembrane transport in mitochondrion" RELATED [] is_a: GO:1901475 ! pyruvate transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0006851 name: mitochondrial calcium ion transmembrane transport namespace: biological_process def: "The process in which a calcium ion (Ca2+) is transported across a mitochondrial membrane, into or out of the mitochondrion." [GOC:ai] synonym: "mitochondrial calcium transport" EXACT [] is_a: GO:0070588 ! calcium ion transmembrane transport [Term] id: GO:0006852 name: obsolete mitochondrial sodium/calcium ion exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents function rather than a process. synonym: "mitochondrial sodium/calcium exchange" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" EXACT [] is_obsolete: true consider: GO:0005432 consider: GO:0006814 consider: GO:0006816 consider: GO:0006839 [Term] id: GO:0006853 name: carnitine shuttle namespace: biological_process def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0032365 ! intracellular lipid transport is_a: GO:1902001 ! fatty acid transmembrane transport is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0006854 name: obsolete ATP/ADP exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "ATP/ADP exchange" EXACT [] is_obsolete: true replaced_by: GO:0005471 [Term] id: GO:0006855 name: drug transmembrane transport namespace: biological_process def: "The process in which a drug is transported across a membrane." [GOC:ai, GOC:bf] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "drug membrane transport" EXACT [] synonym: "multidrug transport" RELATED [] is_a: GO:0015893 ! drug transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0006856 name: eye pigment precursor transport namespace: biological_process def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006810 ! transport relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0006857 name: oligopeptide transport namespace: biological_process def: "The directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732] is_a: GO:0015833 ! peptide transport [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] is_a: GO:0006810 ! transport [Term] id: GO:0006859 name: extracellular carbohydrate transport namespace: biological_process def: "The directed extracellular movement of carbohydrates." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0006863 name: purine nucleobase transport namespace: biological_process alt_id: GO:0015852 def: "The directed movement of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26386, ISBN:0198506732] synonym: "purine base transmembrane transport" EXACT [GOC:mah] synonym: "purine base transport" EXACT [GOC:go_curators] synonym: "purine transmembrane transport" RELATED [GOC:mah] synonym: "purine transport" RELATED [GOC:curators] is_a: GO:0015851 ! nucleobase transport [Term] id: GO:0006864 name: pyrimidine nucleotide transport namespace: biological_process def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast is_a: GO:0046942 ! carboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0006867 name: asparagine transport namespace: biological_process def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-asparagine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0042886 ! amide transport [Term] id: GO:0006868 name: glutamine transport namespace: biological_process alt_id: GO:0015815 def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-glutamine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732] subset: goslim_pir subset: goslim_yeast is_a: GO:0071702 ! organic substance transport relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006873 name: cellular ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of ions at the level of a cell." [GOC:mah] subset: goslim_yeast is_a: GO:0050801 ! ion homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0006874 name: cellular calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055074 ! calcium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006875 name: cellular metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of metal ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cellular heavy metal ion homeostasis" NARROW [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0006876 name: cellular cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cadmium homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055073 ! cadmium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006877 name: cellular cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055068 ! cobalt ion homeostasis [Term] id: GO:0006878 name: cellular copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of copper ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "copper homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055070 ! copper ion homeostasis [Term] id: GO:0006879 name: cellular iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of iron ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "iron homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055072 ! iron ion homeostasis [Term] id: GO:0006880 name: intracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] synonym: "intracellular iron ion retention" EXACT [] synonym: "intracellular iron ion sequestering" EXACT [] synonym: "intracellular iron ion sequestration" EXACT [] synonym: "intracellular iron ion storage" EXACT [] synonym: "intracellular retention of iron ion" EXACT [] synonym: "intracellular sequestration of iron ion" EXACT [] synonym: "intracellular storage of iron ion" EXACT [] is_a: GO:0051651 ! maintenance of location in cell is_a: GO:0097577 ! sequestering of iron ion [Term] id: GO:0006881 name: extracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai, GOC:cjm] synonym: "extracellular iron ion retention" EXACT [] synonym: "extracellular iron ion sequestering" EXACT [] synonym: "extracellular iron ion sequestration" EXACT [] synonym: "extracellular iron ion storage" EXACT [] synonym: "extracellular retention of iron ion" EXACT [] synonym: "extracellular sequestration of iron ion" EXACT [] synonym: "extracellular storage of iron ion" EXACT [] is_a: GO:0097577 ! sequestering of iron ion [Term] id: GO:0006882 name: cellular zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055069 ! zinc ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0006883 name: cellular sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis [Term] id: GO:0006884 name: cell volume homeostasis namespace: biological_process def: "Any process involved in maintaining the steady state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0008361 ! regulation of cell size is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0006885 name: regulation of pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process alt_id: GO:0032779 def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] synonym: "copper-induced intracellular protein transport" RELATED [GOC:al] is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle. Exocytosis can occur either by full fusion, when the vesicle collapses into the plasma membrane, or by a kiss-and-run mechanism that involves the formation of a transient contact, a pore, between a granule (for exemple of chromaffin cells) and the plasma membrane. The latter process most of the time leads to only partial secretion of the granule content. Exocytosis begins with steps that prepare vesicles for fusion with the membrane (tethering and docking) and ends when molecules are secreted from the cell." [GOC:mah, ISBN:0716731363, PMID:22323285] subset: goslim_yeast synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0006888 name: endoplasmic reticulum to Golgi vesicle-mediated transport namespace: biological_process alt_id: GO:0048221 def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] synonym: "anterograde (ER to Golgi) transport" EXACT [] synonym: "anterograde transport, endoplasmic reticulum to Golgi" EXACT [] synonym: "anterograde transport, ER to Golgi" EXACT [] synonym: "anterograde vesicle-mediated transport, endoplasmic reticulum to Golgi" EXACT [] synonym: "anterograde vesicle-mediated transport, ER to Golgi" EXACT [] synonym: "endoplasmic reticulum to Golgi transport" EXACT [] synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [] synonym: "ER to Golgi transport" EXACT [] synonym: "ER to Golgi vesicle-mediated transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] synonym: "rough ER to cis-Golgi transport" EXACT [] synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006889 name: obsolete regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). synonym: "regulation of calcium in ER" EXACT [] is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0006890 name: retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum namespace: biological_process alt_id: GO:0048220 def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] synonym: "cis-Golgi to rough ER transport" EXACT [] synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT [] synonym: "retrograde (Golgi to ER) transport" EXACT [] synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] synonym: "retrograde transport, Golgi to ER" EXACT [] synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [] synonym: "retrograde vesicle-mediated transport, Golgi to ER" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006891 name: intra-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] synonym: "intra-Golgi transport" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0098876 ! vesicle-mediated transport to the plasma membrane [Term] id: GO:0006894 name: obsolete Golgi to secretory vesicle transport namespace: biological_process def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. synonym: "Golgi to secretory vesicle transport" EXACT [] synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] is_obsolete: true consider: GO:0055107 consider: GO:0055108 [Term] id: GO:0006895 name: Golgi to endosome transport namespace: biological_process alt_id: GO:0048218 def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] synonym: "TGN to endosome transport" EXACT [] synonym: "trans-Golgi to endosome transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0016482 ! cytosolic transport [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 alt_id: GO:0098701 def: "A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732, ISBN:0716731363] subset: goslim_yeast synonym: "endocytic import into cell" EXACT [] synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" NARROW [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0098657 ! import into cell [Term] id: GO:0006898 name: receptor-mediated endocytosis namespace: biological_process def: "An endocytosis process in which cell surface receptors ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [GOC:mah, ISBN:0716731363] synonym: "receptor mediated endocytosis" EXACT [] xref: Wikipedia:Receptor-mediated_endocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006900 name: vesicle budding from membrane namespace: biological_process alt_id: GO:0006902 alt_id: GO:1902591 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "single organism membrane budding" RELATED [GOC:TermGenie] synonym: "single-organism membrane budding" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016050 ! vesicle organization is_a: GO:0061024 ! membrane organization relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006901 name: vesicle coating namespace: biological_process def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] synonym: "vesicle coat assembly" BROAD [] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0006900 ! vesicle budding from membrane [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process in which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006904 name: vesicle docking involved in exocytosis namespace: biological_process def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048278 ! vesicle docking is_a: GO:0140029 ! exocytic process [Term] id: GO:0006905 name: obsolete vesicle transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "vesicle transport" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0016050 ! vesicle organization is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006907 name: pinocytosis namespace: biological_process alt_id: GO:0006908 alt_id: GO:1902536 def: "An endocytosis process that results in the uptake of liquid material by cells from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, called pinosomes, formed by invagination of the plasma membrane." [ISBN:0198506732] synonym: "clathrin-independent pinocytosis" BROAD [] synonym: "fluid-phase endocytosis" EXACT [] synonym: "single-organism pinocytosis" RELATED [] xref: Wikipedia:Pinocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "A vesicle-mediated transport process that results in the engulfment of external particulate material by phagocytes and their delivery to the lysosome. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732] xref: Wikipedia:Phagocytosis is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006910 name: phagocytosis, recognition namespace: biological_process def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149] comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0006897 ! endocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006911 name: phagocytosis, engulfment namespace: biological_process def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149] synonym: "phagosome biosynthesis" RELATED [] synonym: "phagosome formation" RELATED [] is_a: GO:0099024 ! plasma membrane invagination relationship: part_of GO:0006897 ! endocytosis relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006912 name: obsolete phagosome formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because of the ambiguity in its meaning. synonym: "phagosome formation" EXACT [] is_obsolete: true consider: GO:0001845 consider: GO:0006911 [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] comment: Note that transport through the nuclear pore complex is not transmembrane because the nuclear membrane is a double membrane, and is not traversed. subset: goslim_chembl subset: goslim_generic subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport [Term] id: GO:0006914 name: autophagy namespace: biological_process alt_id: GO:0016238 def: "The cellular catabolic process in which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [GOC:autophagy, ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process is_a: GO:0061919 ! process utilizing autophagic mechanism [Term] id: GO:0006915 name: apoptotic process namespace: biological_process alt_id: GO:0006917 alt_id: GO:0008632 def: "A programmed cell death process which begins when a cell receives an internal (e.g. DNA damage) or external signal (e.g. an extracellular death ligand), and proceeds through a series of biochemical events (signaling pathway phase) which trigger an execution phase. The execution phase is the last step of an apoptotic process, and is typically characterized by rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died." [GOC:cjm, GOC:dhl, GOC:ecd, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb, ISBN:0198506732, PMID:18846107, PMID:21494263] subset: goslim_pombe synonym: "activation of apoptosis" NARROW [] synonym: "apoptosis" NARROW [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" NARROW [] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "caspase-dependent programmed cell death" RELATED [] synonym: "cell suicide" BROAD [] synonym: "cellular suicide" BROAD [] synonym: "commitment to apoptosis" RELATED [] synonym: "induction of apoptosis" RELATED [] synonym: "induction of apoptosis by p53" RELATED [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006918 name: obsolete induction of apoptosis by p53 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. synonym: "induction of apoptosis by p53" EXACT [] is_obsolete: true consider: GO:0006915 [Term] id: GO:0006919 name: activation of cysteine-type endopeptidase activity involved in apoptotic process namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process." [GOC:al, GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, PMID:18328827, Wikipedia:Caspase] comment: This term should be used when the annotation refers to a process that occurs in a context of apoptotic cell death. To annotate gene products involved in activation of cysteine-type endopeptidases in other cellular process (e.g., cell cycle arrest) that do not necessarily develop into an apoptotic process, please use the more general parent term GO:0097202. Examples of 'activation of cysteine-type endopeptidase activity involved in apoptotic process' are cytochrome c and Apaf1. When cytochrome c is released from mitochondria and forms a complex with Apaf1, they form a scaffolding platform in which the pro-caspase 9 is bound (the 'apoptosome'). The caspase is then cleaved and activated. Cytochrome c and Apaf1 are therefore involved in the conversion of the zymogen procaspase 9 to the active form of the caspase. synonym: "activation of caspase activity" NARROW [] synonym: "activation of metacaspase activity" NARROW [] synonym: "caspase activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0043280 ! positive regulation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0006920 name: obsolete commitment to apoptosis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. synonym: "commitment to apoptosis" EXACT [] is_obsolete: true consider: GO:0006915 [Term] id: GO:0006921 name: cellular component disassembly involved in execution phase of apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb] synonym: "cellular component disassembly involved in apoptosis" NARROW [] synonym: "cellular component disassembly involved in apoptotic process" BROAD [] synonym: "disassembly of cell structures" BROAD [] is_a: GO:0022411 ! cellular component disassembly relationship: part_of GO:0097194 ! execution phase of apoptosis [Term] id: GO:0006922 name: obsolete cleavage of lamin involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, GOC:mtg_apoptosis, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "cleavage of lamin" BROAD [] synonym: "cleavage of lamin involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0006923 name: obsolete cleavage of cytoskeletal proteins involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] synonym: "cleavage of cytoskeletal proteins involved in apoptosis" BROAD [] synonym: "cleavage of cytoskeletal proteins involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0006924 name: activation-induced cell death of T cells namespace: biological_process def: "A T cell apoptotic process that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, GOC:mtg_apoptosis, ISBN:0781765196, PMID:12414721, PMID:12752672] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "AICD" BROAD [GOC:add] synonym: "antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0070231 ! T cell apoptotic process relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0006925 name: inflammatory cell apoptotic process namespace: biological_process def: "Any apoptotic process in an inflammatory cell, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, GOC:mtg_apoptosis, http://www.mercksource.com/] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell apoptosis" NARROW [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0006926 name: obsolete virus-infected cell apoptotic process namespace: biological_process def: "OBSOLETE. Any apoptotic process in a cell infected with a virus." [GOC:jl, GOC:mtg_apoptosis] comment: This term was made obsolete because the meaning of the term is ambiguous, as it's possibly conflating at least two scenarios: 1) the organism apoptoses its own cell because it detects it is infected with a virus; 2) the virus induces apoptosis so the cell is lysed and the virus disseminated. Please consider using viral process terms to annotate viral proteins. As for the cellular apoptotic process, this likely occurs via the same mechanisms described by existing apoptotic process terms, so please consider using those to annotate cellular proteins. synonym: "apoptosis of virus-infected cells" EXACT [] synonym: "killing virus-infected cells" EXACT [] synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] synonym: "programmed cell death, virus-infected cells" EXACT [] synonym: "virus-infected cell apoptosis" NARROW [] synonym: "virus-infected cell apoptotic process" EXACT [] synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0006927 name: obsolete transformed cell apoptotic process namespace: biological_process def: "OBSOLETE. Any apoptotic process in a transformed cell, a cell that has undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, GOC:mtg_apoptosis, MeSH:C04.697.152] comment: This term was made obsolete because it does not refer to a normal process. synonym: "apoptosis of transformed cells" EXACT [] synonym: "killing transformed cells" EXACT [] synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] synonym: "programmed cell death, transformed cells" EXACT [] synonym: "transformed cell apoptosis" NARROW [] synonym: "transformed cell programmed cell death by apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0006928 name: movement of cell or subcellular component namespace: biological_process def: "The directed, self-propelled movement of a cell or subcellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: gocheck_do_not_annotate subset: goslim_pir synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] synonym: "cellular component movement" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0006929 name: substrate-dependent cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration" EXACT [GOC:curators] is_a: GO:0016477 ! cell migration [Term] id: GO:0006930 name: substrate-dependent cell migration, cell extension namespace: biological_process def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell extension" EXACT [GOC:curators] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006931 name: substrate-dependent cell migration, cell attachment to substrate namespace: biological_process def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell attachment to substrate" EXACT [GOC:curators] is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006932 name: substrate-dependent cell migration, cell contraction namespace: biological_process def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell contraction" EXACT [GOC:curators] is_a: GO:0060327 ! cytoplasmic actin-based contraction involved in cell motility relationship: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006933 name: negative regulation of cell adhesion involved in substrate-bound cell migration namespace: biological_process def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0006929 ! substrate-dependent cell migration [Term] id: GO:0006934 name: substrate-bound cell migration, adhesion receptor recycling namespace: biological_process def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732] synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042330 ! taxis relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process in which force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732] subset: goslim_pir xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process relationship: regulates GO:0006936 ! muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction relationship: regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process in which force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, ISBN:0198506732] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction relationship: regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0006943 name: obsolete chemi-mechanical coupling namespace: biological_process def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com] comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. synonym: "chemi-mechanical coupling" EXACT [] synonym: "mechanochemical coupling" EXACT [] is_obsolete: true consider: GO:0009612 consider: GO:0050954 [Term] id: GO:0006945 name: obsolete nuclear fusion during karyogamy namespace: biological_process def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. synonym: "nuclear fusion during karyogamy" EXACT [] is_obsolete: true consider: GO:0000741 [Term] id: GO:0006948 name: induction by virus of host cell-cell fusion namespace: biological_process def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] comment: Where syncytium formation results in the spread of virus in the host, also consider annotating to the term 'spread of virus in multicellular host ; GO:0046739'. synonym: "induction by virus of cell-cell fusion in host" EXACT [] synonym: "viral-induced cell-cell fusion" EXACT [] synonym: "viral-induced host cell-cell fusion" EXACT [] synonym: "viral-induced membrane fusion" NARROW [] is_a: GO:0019054 ! modulation by virus of host process [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006953 name: acute-phase response namespace: biological_process def: "An acute inflammatory response that involves non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "Inflammation" BROAD [] xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was redefined and moved. is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006956 name: complement activation namespace: biological_process def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "complement activity" RELATED [] synonym: "complement cascade" EXACT [GOC:add] synonym: "complement response" EXACT [] is_a: GO:0002252 ! immune effector process is_a: GO:0002253 ! activation of immune response is_a: GO:0006959 ! humoral immune response [Term] id: GO:0006957 name: complement activation, alternative pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149] synonym: "complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0006958 name: complement activation, classical pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149] synonym: "complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0006956 ! complement activation relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0006959 name: humoral immune response namespace: biological_process def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732] xref: Wikipedia:Humoral_immunity is_a: GO:0006955 ! immune response [Term] id: GO:0006962 name: male-specific antibacterial humoral response namespace: biological_process def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] is_a: GO:0019731 ! antibacterial humoral response is_a: GO:0050831 ! male-specific defense response to bacterium [Term] id: GO:0006963 name: positive regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] synonym: "antibacterial peptide induction" EXACT [] synonym: "antibacterial polypeptide induction" EXACT [] synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] is_a: GO:0002803 ! positive regulation of antibacterial peptide production is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0006964 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0006965 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0006967 name: positive regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] synonym: "activation of antifungal peptide biosynthetic process" NARROW [] synonym: "antifungal peptide induction" EXACT [] synonym: "antifungal polypeptide induction" EXACT [] synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] is_a: GO:0002804 ! positive regulation of antifungal peptide production is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0006968 name: cellular defense response namespace: biological_process alt_id: GO:0016066 alt_id: GO:0016067 def: "A defense response that is mediated by cells." [GOC:ebc] comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes. synonym: "cellular defence response" EXACT [] is_a: GO:0006952 ! defense response [Term] id: GO:0006969 name: obsolete melanotic tumor response namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it was undefined and represented an abnormal process. synonym: "melanotic mass response" EXACT [] synonym: "melanotic tumor response" EXACT [] is_obsolete: true [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: goslim_yeast synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0006971 name: hypotonic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, PMID:12598593] synonym: "hypo-osmotic response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, PMID:12142009] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006973 name: intracellular accumulation of glycerol namespace: biological_process def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] is_a: GO:0019725 ! cellular homeostasis relationship: part_of GO:0071474 ! cellular hyperosmotic response [Term] id: GO:0006974 name: cellular response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: goslim_yeast synonym: "cellular DNA damage response" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to DNA damage stimulus" BROAD [] synonym: "response to genotoxic stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0006975 name: DNA damage induced protein phosphorylation namespace: biological_process def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0006974 ! cellular response to DNA damage stimulus [Term] id: GO:0006977 name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0071158 ! positive regulation of cell cycle arrest is_a: GO:0072431 ! signal transduction involved in mitotic G1 DNA damage checkpoint [Term] id: GO:0006978 name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: goslim_yeast is_a: GO:0006950 ! response to stress [Term] id: GO:0006981 name: obsolete activation of SoxR protein namespace: biological_process def: "OBSOLETE The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] comment: This term was made obsolete because it was too specific with respect to a single gene product. is_obsolete: true [Term] id: GO:0006982 name: response to lipid hydroperoxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] synonym: "response to LHPO" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0006983 name: ER overload response namespace: biological_process def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] synonym: "endoplasmic reticulum overload response" EXACT [] synonym: "EOR" EXACT [] synonym: "ER-overload response" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0006984 name: ER-nucleus signaling pathway namespace: biological_process def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] synonym: "ER to nucleus signaling pathway" EXACT [] synonym: "ER to nucleus signalling pathway" EXACT [] synonym: "ER-nuclear signaling pathway" EXACT [] synonym: "ER-nuclear signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0006985 name: positive regulation of NF-kappaB transcription factor activity by ER overload response namespace: biological_process def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516] synonym: "EOR-mediated activation of NF-kappaB" EXACT [GOC:dph, GOC:tb] synonym: "EOR-mediated NF-kappaB activation" EXACT [] synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb] is_a: GO:0006983 ! ER overload response is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity [Term] id: GO:0006986 name: response to unfolded protein namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. synonym: "heat shock protein activity" RELATED [] is_a: GO:0035966 ! response to topologically incorrect protein [Term] id: GO:0006987 name: obsolete activation of signaling protein activity involved in unfolded protein response namespace: biological_process def: "OBSOLETE. The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] comment: The reason for obsoletion is that this process represents a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] is_obsolete: true consider: GO:0036498 [Term] id: GO:0006988 name: obsolete unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" EXACT [] is_obsolete: true consider: GO:0004521 [Term] id: GO:0006989 name: obsolete unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" EXACT [] is_obsolete: true consider: GO:0008452 [Term] id: GO:0006990 name: positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response namespace: biological_process def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, GOC:txnOH, PMID:12042763] synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of target gene transcription" NARROW [] synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006991 name: response to sterol depletion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732] synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb] is_a: GO:0006950 ! response to stress [Term] id: GO:0006995 name: cellular response to nitrogen starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043562 ! cellular response to nitrogen levels [Term] id: GO:0006996 name: organelle organization namespace: biological_process alt_id: GO:1902589 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] synonym: "single organism organelle organization" EXACT [GOC:TermGenie] synonym: "single-organism organelle organization" RELATED [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [GOC:curators] synonym: "nuclear organization" EXACT [GOC:curators] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0006997 ! nucleus organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0006999 name: nuclear pore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear pore organisation" EXACT [GOC:curators] synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [GOC:curators] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0007002 name: obsolete centromere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "centromere binding" EXACT [] is_obsolete: true replaced_by: GO:0019237 [Term] id: GO:0007003 name: obsolete telomere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. synonym: "telomere binding" EXACT [] is_obsolete: true replaced_by: GO:0042162 [Term] id: GO:0007004 name: telomere maintenance via telomerase namespace: biological_process def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] synonym: "telomerase-dependent telomere maintenance" EXACT [] is_a: GO:0006278 ! RNA-dependent DNA biosynthetic process is_a: GO:0010833 ! telomere maintenance via telomere lengthening [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0061024 ! membrane organization [Term] id: GO:0007007 name: inner mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "inner mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] synonym: "mitochondrial inner membrane organization" EXACT [GOC:curators] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "plasma membrane organisation" EXACT [GOC:curators] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007011 name: obsolete regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. synonym: "regulation of cytoskeleton" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0007014 name: actin ubiquitination namespace: biological_process def: "The modification of actin by addition of ubiquitin groups." [GOC:mah] synonym: "indirect flight muscle actin ubiquitination" NARROW [GOC:mah] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0030047 ! actin modification [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [GOC:curators] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0097435 ! supramolecular fiber organization relationship: part_of GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0007016 name: cytoskeletal anchoring at plasma membrane namespace: biological_process def: "A cytoskeleton organization process that directly or indirectly links cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] synonym: "cytoskeletal anchoring activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] subset: goslim_chembl is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules." [GOC:cjm, ISBN:0815316194] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] synonym: "microtubule shortening" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The process in which tubulin alpha-beta heterodimers begin aggregation to form an oligomeric tubulin structure (a microtubule seed). Microtubule nucleation is the initiating step in the formation of a microtubule in the absence of any existing microtubules ('de novo' microtubule formation)." [GOC:go_curators, ISBN:0815316194, PMID:12517712] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0046785 ! microtubule polymerization [Term] id: GO:0007021 name: tubulin complex assembly namespace: biological_process def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] synonym: "tubulin assembly" EXACT [] synonym: "tubulin folding" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0007023 name: post-chaperonin tubulin folding pathway namespace: biological_process def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] is_a: GO:0006457 ! protein folding [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization relationship: negatively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010937 ! regulation of cytoplasmic microtubule depolymerization is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "cytoplasm organisation" EXACT [GOC:curators] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0007029 name: endoplasmic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endoplasmic reticulum morphology" RELATED [] synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators] synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] synonym: "ER organisation" EXACT [GOC:curators] synonym: "ER organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi organisation" EXACT [GOC:curators] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [GOC:curators] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007032 name: endosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endosome organisation" EXACT [GOC:curators] synonym: "endosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0010256 ! endomembrane system organization [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [GOC:curators] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] subset: goslim_chembl subset: goslim_generic is_a: GO:0006810 ! transport [Term] id: GO:0007035 name: vacuolar acidification namespace: biological_process def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0007038 name: endocytosed protein transport to vacuole namespace: biological_process def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] comment: See also the biological process term 'endocytosis ; GO:0006897'. synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] is_a: GO:0007034 ! vacuolar transport is_a: GO:0015031 ! protein transport [Term] id: GO:0007039 name: protein catabolic process in the vacuole namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah, GOC:vw] synonym: "vacuolar protein breakdown" RELATED [] synonym: "vacuolar protein catabolic process" RELATED [] synonym: "vacuolar protein catabolism" RELATED [] synonym: "vacuolar protein degradation" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] synonym: "lysosome organisation" EXACT [GOC:curators] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0080171 ! lytic vacuole organization [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007042 name: lysosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] synonym: "lysosome pH reduction" EXACT [GOC:bf, GOC:rph] is_a: GO:0007035 ! vacuolar acidification is_a: GO:0035751 ! regulation of lysosomal lumen pH [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0007044 name: cell-substrate junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] is_a: GO:0034329 ! cell junction assembly [Term] id: GO:0007045 name: cell-substrate adherens junction assembly namespace: biological_process def: "The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction." [GOC:mah] synonym: "hemi-adherens junction assembly" RELATED [GOC:mah] is_a: GO:0007044 ! cell-substrate junction assembly is_a: GO:0034333 ! adherens junction assembly [Term] id: GO:0007048 name: obsolete oncogenesis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a pathological process. synonym: "oncogenesis" EXACT [] is_obsolete: true [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators, GOC:mtg_cell_cycle] subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007050 name: cell cycle arrest namespace: biological_process def: "A regulatory process that halts progression through the cell cycle during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0007051 name: spindle organization namespace: biological_process alt_id: GO:0043146 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:go_curators, GOC:mah] synonym: "spindle organisation" EXACT [GOC:curators] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle stabilization" RELATED [] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0022402 ! cell cycle process [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process alt_id: GO:0000071 alt_id: GO:0030472 alt_id: GO:0043148 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:go_curators, GOC:mah] comment: In fission yeast most mitotic spindle organization occurs in the nucleus; see https://github.com/geneontology/go-ontology/issues/15341. synonym: "mitotic spindle organisation" EXACT [GOC:curators] synonym: "mitotic spindle organisation in nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "mitotic spindle organization and biogenesis in cell nucleus" NARROW [] synonym: "mitotic spindle organization and biogenesis in nucleus" NARROW [] synonym: "mitotic spindle organization in nucleus" NARROW [] synonym: "mitotic spindle stabilization" RELATED [] synonym: "spindle organization and biogenesis during mitosis" EXACT [] synonym: "spindle organization and biogenesis in nucleus during mitosis" NARROW [] is_a: GO:0007051 ! spindle organization is_a: GO:1902850 ! microtubule cytoskeleton organization involved in mitosis [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007054 name: spindle assembly involved in male meiosis I namespace: biological_process def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis I spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007141 ! male meiosis I [Term] id: GO:0007055 name: spindle assembly involved in male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis II spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007142 ! male meiosis II [Term] id: GO:0007056 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiotic spindle assembly" RELATED [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007057 name: spindle assembly involved in female meiosis I namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis I spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007144 ! female meiosis I [Term] id: GO:0007058 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis II spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007147 ! female meiosis II [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles." [GOC:jl, GOC:mah, GOC:mtg_cell_cycle, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0009987 ! cellular process [Term] id: GO:0007060 name: male meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007062 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome become tethered to each other." [GOC:jh, GOC:mah, ISBN:0815316194] synonym: "coheson-mediated DNA tethering" EXACT [] synonym: "sister chromatid alignment" RELATED [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0000819 ! sister chromatid segregation [Term] id: GO:0007063 name: regulation of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] is_a: GO:0033045 ! regulation of sister chromatid segregation relationship: regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0007064 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process in which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] is_a: GO:0007062 ! sister chromatid cohesion is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007065 name: male meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007066 name: female meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007068 name: obsolete negative regulation of transcription during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription" EXACT [] synonym: "negative regulation of transcription, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007069 name: obsolete negative regulation of transcription from RNA polymerase I promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase I promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from Pol I promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007070 name: obsolete negative regulation of transcription from RNA polymerase II promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase II promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from Pol II promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007071 name: obsolete negative regulation of transcription from RNA polymerase III promoter during mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter that occurs during the mitotic cell cycle." [GOC:go_curators] comment: The reason for obsoletion is that 'during' should be captured using an annotation extension. See also comments here: https://github.com/geneontology/go-ontology/issues/14896 synonym: "down regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "down-regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "downregulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:mah] synonym: "inhibition of transcription from RNA polymerase III promoter during mitosis" NARROW [GOC:mah] synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from Pol III promoter during mitosis" EXACT [GOC:mah] synonym: "negative regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0007072 name: positive regulation of transcription involved in exit from mitosis namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0010458 ! exit from mitosis [Term] id: GO:0007073 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase I promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007074 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007075 name: positive regulation of transcription involved in exit from mitosis, from RNA polymerase III promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] is_a: GO:0007072 ! positive regulation of transcription involved in exit from mitosis [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process in which chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0030261 ! chromosome condensation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process in which the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" EXACT [] synonym: "mitotic nuclear envelope degradation" EXACT [] is_a: GO:0051081 ! nuclear envelope disassembly is_a: GO:1903047 ! mitotic cell cycle process [Term] id: GO:0007078 name: lamin depolymerization namespace: biological_process def: "The cell cycle process in which lamin is depolymerized." [GOC:jid] is_a: GO:0051261 ! protein depolymerization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly [Term] id: GO:0007079 name: mitotic chromosome movement towards spindle pole namespace: biological_process alt_id: GO:0007082 def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] synonym: "chromosome migration to spindle pole during mitosis" EXACT [] synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] synonym: "mitotic chromosome movement" BROAD [] synonym: "mitotic chromosome movement to spindle pole" EXACT [] synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] is_a: GO:0051305 ! chromosome movement towards spindle pole is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007080 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process in which chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] is_a: GO:0051310 ! metaphase plate congression is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007081 name: obsolete mitotic sister-chromatid adhesion release namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. synonym: "mitotic sister-chromatid adhesion release" EXACT [] is_obsolete: true consider: GO:0000070 consider: GO:0007064 [Term] id: GO:0007083 name: mitotic chromosome decondensation namespace: biological_process def: "The cell cycle process in which chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] is_a: GO:0051312 ! chromosome decondensation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007084 name: mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in reformation of the nuclear envelope during mitotic cell division." [GOC:ai] is_a: GO:0031468 ! nuclear envelope reassembly is_a: GO:1903047 ! mitotic cell cycle process [Term] id: GO:0007085 name: obsolete nuclear membrane vesicle binding to chromatin namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. synonym: "nuclear membrane vesicle binding to chromatin" EXACT [] is_obsolete: true consider: GO:0003682 [Term] id: GO:0007086 name: vesicle fusion with nuclear membrane involved in mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process that results in the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus, and contributes to mitotic nuclear envelope reassembly." [GOC:jid, GOC:mah] is_a: GO:0000740 ! nuclear membrane fusion is_a: GO:0006906 ! vesicle fusion is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007087 name: mitotic nuclear pore complex reassembly namespace: biological_process def: "The cell cycle process in which nuclear pore complexes reform during mitotic cell division." [GOC:ai] is_a: GO:0051292 ! nuclear pore complex assembly is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007088 name: regulation of mitotic nuclear division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] synonym: "regulation of mitosis" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division relationship: regulates GO:0140014 ! mitotic nuclear division [Term] id: GO:0007089 name: traversing start control point of mitotic cell cycle namespace: biological_process alt_id: GO:0000081 def: "A cell cycle process by which a cell commits to entering S phase via a positive feedback mechanism between the regulation of transcription and G1 CDK activity." [GOC:mtg_cell_cycle] is_a: GO:1900087 ! positive regulation of G1/S transition of mitotic cell cycle [Term] id: GO:0007090 name: obsolete regulation of S phase of mitotic cell cycle namespace: biological_process def: "OBSOLETE. A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] comment: This term was made obsolete as part of the cell cycle overhaul. This is because it was decided that cell cycle phases are intervals and so cannot be regulated, rather it is the transitions between the phases that are regulated. synonym: "regulation of S phase of mitotic cell cycle" EXACT [] synonym: "regulation of S-phase of mitotic cell cycle" EXACT [] is_obsolete: true consider: GO:0044772 [Term] id: GO:0007091 name: metaphase/anaphase transition of mitotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mtg_cell_cycle, PMID:10465783] synonym: "metaphase/anaphase transition by anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] synonym: "mitotic metaphase/anaphase transition" EXACT [] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:0044772 ! mitotic cell cycle phase transition is_a: GO:0044784 ! metaphase/anaphase transition of cell cycle [Term] id: GO:0007093 name: mitotic cell cycle checkpoint namespace: biological_process alt_id: GO:0031575 alt_id: GO:0071780 def: "A cell cycle checkpoint that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mtg_cell_cycle] synonym: "mitotic checkpoint" RELATED [] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0045930 ! negative regulation of mitotic cell cycle is_a: GO:1903047 ! mitotic cell cycle process [Term] id: GO:0007094 name: mitotic spindle assembly checkpoint namespace: biological_process alt_id: GO:0044810 def: "A cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle." [GOC:mtg_cell_cycle, PMID:12360190] synonym: "Dma1-dependent checkpoint" NARROW [] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "mitotic cell cycle spindle assembly checkpoint" EXACT [] synonym: "SAC-independent checkpoint" NARROW [] is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0071173 ! spindle assembly checkpoint is_a: GO:0071174 ! mitotic spindle checkpoint [Term] id: GO:0007095 name: mitotic G2 DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0031572 ! G2 DNA damage checkpoint is_a: GO:0044773 ! mitotic DNA damage checkpoint is_a: GO:0044818 ! mitotic G2/M transition checkpoint [Term] id: GO:0007096 name: regulation of exit from mitosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition relationship: regulates GO:0010458 ! exit from mitosis [Term] id: GO:0007097 name: nuclear migration namespace: biological_process alt_id: GO:0040023 def: "The directed movement of the nucleus to a specific location within a cell." [GOC:ai] subset: goslim_aspergillus synonym: "establishment of cell nucleus localization" RELATED [] synonym: "establishment of localization of nucleus" RELATED [] synonym: "establishment of nucleus localisation" RELATED [GOC:mah] synonym: "establishment of nucleus localization" RELATED [] synonym: "establishment of position of nucleus" EXACT [] synonym: "nuclear movement" EXACT [] synonym: "nuclear positioning" EXACT [] synonym: "nucleus migration" EXACT [] synonym: "nucleus positioning" EXACT [] synonym: "positioning of nucleus" EXACT [] is_a: GO:0046907 ! intracellular transport is_a: GO:0051647 ! nucleus localization is_a: GO:0051656 ! establishment of organelle localization [Term] id: GO:0007098 name: centrosome cycle namespace: biological_process alt_id: GO:0051297 def: "The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] synonym: "centrosome organisation" EXACT [GOC:curators] synonym: "centrosome organization" EXACT [] synonym: "centrosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0022402 ! cell cycle process is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0007099 name: centriole replication namespace: biological_process alt_id: GO:0032054 def: "The cell cycle process in which a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type. Duplicated centrioles also become the ciliary basal body in cells that form cilia during G0." [GOC:cilia, GOC:kmv, ISBN:0815316194, PMID:9889124] synonym: "centriole duplication" EXACT [] synonym: "ciliary basal body duplication" RELATED [] synonym: "microtubule basal body duplication" BROAD [] is_a: GO:0022402 ! cell cycle process is_a: GO:0098534 ! centriole assembly relationship: part_of GO:0051298 ! centrosome duplication [Term] id: GO:0007100 name: mitotic centrosome separation namespace: biological_process def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] is_a: GO:0051299 ! centrosome separation is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0007101 name: obsolete male meiosis centrosome cycle namespace: biological_process def: "OBSOLETE. Centrosome duplication and separation in the context of a meiotic cell cycle in a male organism." [GOC:mah] comment: false synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0007105 name: cytokinesis, site selection namespace: biological_process alt_id: GO:0010687 def: "The process of marking the place where cytokinesis will occur." [GOC:mtg_cell_cycle] synonym: "site selection involved in cell cycle cytokinesis" EXACT [] synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007106 name: obsolete cytokinesis, protein recruitment namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined. synonym: "cytokinesis, protein recruitment" EXACT [] is_obsolete: true [Term] id: GO:0007107 name: membrane addition at site of cytokinesis namespace: biological_process def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] synonym: "cytokinesis, membrane recruitment/generation" EXACT [] is_a: GO:0032506 ! cytokinetic process is_a: GO:0061024 ! membrane organization [Term] id: GO:0007108 name: obsolete cytokinesis, initiation of separation namespace: biological_process def: "OBSOLETE. The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. synonym: "cytokinesis, initiation of separation" EXACT [] synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0007109 name: obsolete cytokinesis, completion of separation namespace: biological_process def: "OBSOLETE. The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] comment: This term was obsoleted because it was vaguely defined and had very likely been used in error. Consider the child terms of cytokinesis related to ring positioning, assembly, ring constriction etc. which would be more appropriate. synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis, completion of separation" EXACT [] is_obsolete: true [Term] id: GO:0007110 name: meiosis I cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis I" EXACT [] is_a: GO:0033206 ! meiotic cytokinesis is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0007111 name: meiosis II cytokinesis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:mtg_cell_cycle] synonym: "cytokinesis after meiosis II" EXACT [] is_a: GO:0033206 ! meiotic cytokinesis is_a: GO:0061983 ! meiosis II cell cycle process [Term] id: GO:0007112 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0033206 ! meiotic cytokinesis relationship: part_of GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] comment: Note that this term should not be confused with 'abortive mitotic cell cycle ; GO:0033277'. Although abortive mitosis is sometimes called endomitosis, GO:0033277 refers to a process in which a mitotic spindle forms and chromosome separation begins. synonym: "endomitosis" RELATED [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007114 name: cell budding namespace: biological_process def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732] subset: goslim_candida subset: goslim_yeast synonym: "budding" BROAD [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0032505 ! reproduction of a single-celled organism is_a: GO:0051301 ! cell division [Term] id: GO:0007115 name: obsolete bud site selection/establishment of cell polarity (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents two processes. synonym: "bud site selection/establishment of cell polarity (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0000282 consider: GO:0030010 [Term] id: GO:0007116 name: regulation of cell budding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] synonym: "regulation of budding" BROAD [] is_a: GO:0051302 ! regulation of cell division is_a: GO:1903664 ! regulation of asexual reproduction relationship: regulates GO:0007114 ! cell budding [Term] id: GO:0007117 name: budding cell bud growth namespace: biological_process def: "The process in which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] synonym: "bud growth" BROAD [] is_a: GO:0022414 ! reproductive process is_a: GO:0040007 ! growth relationship: part_of GO:0007114 ! cell budding [Term] id: GO:0007118 name: budding cell apical bud growth namespace: biological_process def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] synonym: "apical bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007119 name: budding cell isotropic bud growth namespace: biological_process def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] synonym: "isotropic bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007120 name: axial cellular bud site selection namespace: biological_process def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] synonym: "axial bud site selection" EXACT [] synonym: "axial budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007121 name: bipolar cellular bud site selection namespace: biological_process def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] synonym: "bipolar bud site selection" EXACT [] synonym: "bipolar budding" BROAD [] synonym: "polar budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007122 name: obsolete loss of asymmetric budding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. synonym: "loss of asymmetric budding" EXACT [] is_obsolete: true consider: GO:0006033 [Term] id: GO:0007123 name: obsolete bud scar accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. synonym: "bud scar accumulation" EXACT [] is_obsolete: true consider: GO:0000282 [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0016049 ! cell growth is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0007125 name: obsolete invasive growth namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it has been split into two new terms. synonym: "invasive growth" EXACT [] is_obsolete: true consider: GO:0001403 consider: GO:0044409 [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "The first meiotic nuclear division in which homologous chromosomes are paired and segregated from each other, producing two haploid daughter nuclei." [GOC:dph, GOC:jl, GOC:mtg_cell_cycle, PMID:9334324] synonym: "meiosis I nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0061982 ! meiosis I cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis I and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007129 name: synapsis namespace: biological_process def: "The meiotic cell cycle process where side by side pairing and physical juxtaposition of homologous chromosomes is created during meiotic prophase. Synapsis begins when the chromosome arms begin to pair from the clustered telomeres and ends when synaptonemal complex or linear element assembly is complete." [GOC:mtg_cell_cycle, PMID:22582262, PMID:23117617] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle relationship: part_of GO:0045143 ! homologous chromosome segregation [Term] id: GO:0007130 name: synaptonemal complex assembly namespace: biological_process def: "The cell cycle process in which the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732] synonym: "synaptonemal complex formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle is_a: GO:0070193 ! synaptonemal complex organization relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0007131 name: reciprocal meiotic recombination namespace: biological_process alt_id: GO:0000021 alt_id: GO:0007145 def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] is_a: GO:0035825 ! homologous recombination is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007132 name: meiotic metaphase I namespace: biological_process def: "The cell cycle phase, following prophase I, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis I." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "The cell cycle phase which follows anaphase I of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098764 ! meiosis I cell cycle phase [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "The second nuclear division of meiosis, in which the two chromatids in each chromosome are separated, resulting in four daughter nuclei from the two nuclei produced in meiosis II." [GOC:dph, GOC:mah, ISBN:0198547684] synonym: "meiosis II nuclear division" EXACT [] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0061983 ! meiosis II cell cycle process is_a: GO:0140013 ! meiotic nuclear division [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "The cell cycle phase which is the first stage of meiosis II and during which chromosomes condense and the two daughter centrioles and their asters migrate toward the poles of the cell." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051324 ! prophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007137 name: meiotic metaphase II namespace: biological_process def: "The cell cycle phase, following prophase II, during which chromosomes become aligned on the equatorial plate of the cell as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051323 ! metaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "The cell cycle phase during which chromosomes separate and migrate towards the poles of the spindle the as part of meiosis II." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051322 ! anaphase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007139 name: meiotic telophase II namespace: biological_process def: "The cell cycle phase which follows anaphase II of meiosis and during which the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct annotation. If you are trying to make an annotation to x phase, it is likely that the correct annotation is 'regulation of x/y phase transition' or to a process which occurs during the reported phase (i.e mitotic DNA replication for mitotic S-phase). To capture the phase when a specific location or process is observed, the phase term can be used in an annotation extension (PMID:24885854) applied to a cellular component term (with the relation exists_during) or a biological process term (with the relation happens_during). subset: gocheck_do_not_annotate is_a: GO:0051326 ! telophase is_a: GO:0098765 ! meiosis II cell cycle phase [Term] id: GO:0007140 name: male meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah, GOC:vw] synonym: "male meiosis" RELATED [] synonym: "male nuclear division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division relationship: part_of GO:0048232 ! male gamete generation [Term] id: GO:0007141 name: male meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I is_a: GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] synonym: "male meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007140 ! male meiotic nuclear division [Term] id: GO:0007143 name: female meiotic nuclear division namespace: biological_process def: "A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah, GOC:vw] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiotic nuclear division; GO:0140013'. synonym: "female meiosis" BROAD [] synonym: "female meiotic division" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0140013 ! meiotic nuclear division relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007144 name: female meiosis I namespace: biological_process def: "The cell cycle process in which the first meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis I nuclear division" EXACT [] is_a: GO:0007127 ! meiosis I is_a: GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007146 name: meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] is_a: GO:0000707 ! meiotic DNA recombinase assembly [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process in which the second meiotic division occurs in the female germline." [GOC:mah] synonym: "female meiosis II nuclear division" EXACT [] is_a: GO:0007135 ! meiosis II is_a: GO:0007143 ! female meiotic nuclear division [Term] id: GO:0007149 name: obsolete colony morphology namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it describes a phenotype rather than a biological goal. synonym: "colony morphology" EXACT [] is_obsolete: true [Term] id: GO:0007150 name: obsolete growth pattern namespace: biological_process def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid] comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. synonym: "growth pattern" EXACT [] is_obsolete: true consider: GO:0040007 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_pir subset: goslim_plant xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process alt_id: GO:0098602 def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_pombe synonym: "cell adhesion molecule activity" RELATED [] synonym: "single organism cell adhesion" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0022610 ! biological adhesion [Term] id: GO:0007156 name: homophilic cell adhesion via plasma membrane adhesion molecules namespace: biological_process def: "The attachment of a plasma membrane adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0007157 name: heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules namespace: biological_process def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732] synonym: "agglutination" RELATED [GOC:mah] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0007158 name: neuron cell-cell adhesion namespace: biological_process def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] synonym: "neuron adhesion" EXACT [GOC:curators] synonym: "neuronal cell adhesion" EXACT [] is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [GOC:curators] synonym: "leukocyte cell adhesion" EXACT [] is_a: GO:0098609 ! cell-cell adhesion [Term] id: GO:0007160 name: cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0007161 name: calcium-independent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "cell polarity" RELATED [GOC:mah, GOC:vw] synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007164 name: establishment of tissue polarity namespace: biological_process def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007165 name: signal transduction namespace: biological_process alt_id: GO:0023033 def: "The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell." [GOC:go_curators, GOC:mtg_signaling_feb11] comment: Note that signal transduction is defined broadly to include a ligand interacting with a receptor, downstream signaling steps and a response being triggered. A change in form of the signal in every step is not necessary. Note that in many cases the end of this process is regulation of the initiation of transcription. Note that specific transcription factors may be annotated to this term, but core/general transcription machinery such as RNA polymerase should not. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "signaling cascade" NARROW [] synonym: "signaling pathway" RELATED [] synonym: "signalling cascade" NARROW [] synonym: "signalling pathway" RELATED [GOC:mah] xref: Wikipedia:Signal_transduction is_a: GO:0009987 ! cellular process is_a: GO:0050794 ! regulation of cellular process relationship: part_of GO:0007154 ! cell communication relationship: part_of GO:0023052 ! signaling relationship: part_of GO:0051716 ! cellular response to stimulus [Term] id: GO:0007166 name: cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by activation of a receptor on the surface of a cell. The pathway begins with binding of an extracellular ligand to a cell surface receptor, or for receptors that signal in the absence of a ligand, by ligand-withdrawal or the activity of a constitutively active receptor. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:mah, GOC:pr, GOC:signaling] synonym: "cell surface receptor linked signal transduction" EXACT [] synonym: "cell surface receptor linked signaling pathway" EXACT [GOC:bf] synonym: "cell surface receptor linked signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007167 name: enzyme linked receptor protein signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, ISBN:0185316194] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007168 name: receptor guanylyl cyclase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses guanylyl cyclase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:16815030] synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007169 name: transmembrane receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, GOC:signaling] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007170 name: obsolete transmembrane receptor protein tyrosine kinase ligand binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. synonym: "transmembrane receptor protein tyrosine kinase ligand binding" EXACT [] is_obsolete: true consider: GO:0030971 [Term] id: GO:0007171 name: activation of transmembrane receptor protein tyrosine kinase activity namespace: biological_process def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007172 name: signal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell." [GOC:bf, GOC:signaling, PMID:9646862] synonym: "signal complex formation" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0007173 name: epidermal growth factor receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor EGFR (ERBB1) on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription." [GOC:ceb, PR:000006933] synonym: "EGF receptor signaling pathway" EXACT [] synonym: "EGF receptor signalling pathway" EXACT [] synonym: "EGFR signaling pathway" EXACT [] synonym: "epidermal growth factor receptor signalling pathway" EXACT [] synonym: "ERBB1 signaling pathway" EXACT [PR:000006933] synonym: "receptor tyrosine-protein kinase erbB-1 signaling pathway" EXACT [PR:000006933] is_a: GO:0038127 ! ERBB signaling pathway [Term] id: GO:0007174 name: epidermal growth factor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of epidermal growth factor (EGF), following internalization of the receptor-bound ligand into the signal-receiving cell. Full breakdown of epidermal growth factor results in a ligand that is unable to bind and activate its receptor." [GOC:bf, GOC:signaling, PMID:2985587] comment: This term describes the breakdown of epidermal growth factor within the cell, following internalization. For proteolysis events that result in the maturation of an epidermal growth factor receptor ligand, see 'epidermal growth factor receptor ligand maturation ; GO:'. synonym: "EGF breakdown" EXACT [GOC:bf] synonym: "EGF catabolism" EXACT [GOC:bf] synonym: "EGF receptor ligand processing" RELATED [GOC:bf] synonym: "epidermal growth factor breakdown" EXACT [GOC:bf] synonym: "epidermal growth factor catabolism" EXACT [GOC:bf] synonym: "epidermal growth factor ligand processing" RELATED [GOC:bf] synonym: "intracellular EGF processing" RELATED [PMID:2985587] synonym: "receptor-mediated EGF processing" RELATED [PMID:1683723] is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007175 name: negative regulation of epidermal growth factor-activated receptor activity namespace: biological_process alt_id: GO:0007177 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of EGF-activated receptor activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] synonym: "EGF receptor downregulation" EXACT [] synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] synonym: "negative regulation of EGF receptor activity" EXACT [] synonym: "negative regulation of EGFR activity" EXACT [] synonym: "negative regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0007176 ! regulation of epidermal growth factor-activated receptor activity is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:2000272 ! negative regulation of signaling receptor activity [Term] id: GO:0007176 name: regulation of epidermal growth factor-activated receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of EGF-activated receptor activity." [GOC:dph, GOC:go_curators] synonym: "regulation of EGF receptor activity" EXACT [] synonym: "regulation of EGFR activity" EXACT [] synonym: "regulation of epidermal growth factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity [Term] id: GO:0007178 name: transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses serine/threonine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007179 name: transforming growth factor beta receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a transforming growth factor beta receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:BHF, GOC:mah, GOC:signaling] synonym: "TGF-beta receptor signaling pathway" EXACT [] synonym: "TGF-beta receptor signalling pathway" EXACT [] synonym: "TGFbeta receptor signaling pathway" EXACT [] synonym: "TGFbeta receptor signalling pathway" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: part_of GO:0071560 ! cellular response to transforming growth factor beta stimulus [Term] id: GO:0007180 name: obsolete transforming growth factor beta ligand binding to type II receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type II receptor" EXACT [] synonym: "TGFbeta ligand binding to type II receptor" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" EXACT [] is_obsolete: true consider: GO:0005026 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0007181 name: transforming growth factor beta receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:R-HSA-170840, Wikipedia:TGF_beta_signaling_pathway] synonym: "TGF-beta receptor complex assembly" EXACT [] synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] synonym: "TGFbeta receptor complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0007182 name: common-partner SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782] synonym: "co-SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "common mediator SMAD protein phosphorylation" EXACT [] synonym: "common partner SMAD protein phosphorylation" EXACT [GOC:rl] synonym: "common-mediator SMAD protein phosphorylation" EXACT [GOC:rl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007183 name: SMAD protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007185 name: transmembrane receptor protein tyrosine phosphatase signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell where the receptor possesses protein tyrosine phosphatase activity, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007186 name: G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0038042 def: "A series of molecular signals that proceeds with an activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, or for basal GPCR signaling the pathway begins with the receptor activating its G protein in the absence of an agonist, and ends with regulation of a downstream cellular process, e.g. transcription. The pathway can start from the plasma membrane, Golgi or nuclear membrane (PMID:24568158 and PMID:16902576)." [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor] synonym: "dimeric G-protein coupled receptor signaling pathway" NARROW [] synonym: "dimeric G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signaling pathway" EXACT [GOC:bf] synonym: "G-protein coupled receptor signaling pathway via GPCR dimer" NARROW [GOC:bf] synonym: "G-protein coupled receptor signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR signaling pathway" EXACT [] synonym: "GPCR signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007187 name: G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cyclic nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via cyclic nucleotide second messenger" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007188 name: adenylate cyclase-modulating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation or inhibition of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase activity. For steps upstream of adenylate cyclase activity, consider instead annotating to 'regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway ; GO:0010578. synonym: "adenylate cyclase-modulating GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cAMP nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via cAMP second messenger" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via modulation of adenylate cyclase activity" EXACT [GOC:signaling] is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [Term] id: GO:0007189 name: adenylate cyclase-activating G protein-coupled receptor signaling pathway namespace: biological_process alt_id: GO:0010579 alt_id: GO:0010580 def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through activation of adenylyl cyclase activity and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term can be used to annotate ligands, receptors and G-proteins that lead to activation of adenylate cyclase activity within a signaling pathway. synonym: "activation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:bf] synonym: "activation of adenylate cyclase activity involved in G-protein signaling" RELATED [GOC:signaling] synonym: "adenylate cyclase-activating GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "GPCR signaling pathway via activation of adenylate cyclase" EXACT [GOC:bf] synonym: "GPCR signaling pathway via activation of adenylate cyclase activity" EXACT [GOC:signaling] synonym: "positive regulation of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] synonym: "positive regulation of adenylate cyclase activity by G-protein signalling pathway" RELATED [GOC:mah] synonym: "positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway is_a: GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0007190 name: activation of adenylate cyclase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] synonym: "adenylate cyclase activator" RELATED [] synonym: "adenylyl cyclase activation" EXACT [] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0007191 name: adenylate cyclase-activating dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:mah, GOC:signaling] synonym: "activation of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" RELATED [GOC:mah] synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007192 name: adenylate cyclase-activating serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007193 name: adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds through inhibition of adenylyl cyclase activity and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of adenylate-cyclase inhibition. synonym: "adenylate cyclase-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "GPCR signaling pathway via inhibition of adenylate cyclase activity" EXACT [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by G-protein signaling pathway" RELATED [GOC:signaling] is_a: GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway [Term] id: GO:0007194 name: negative regulation of adenylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase inhibitor" RELATED [] synonym: "down regulation of adenylate cyclase activity" EXACT [] synonym: "down-regulation of adenylate cyclase activity" EXACT [] synonym: "downregulation of adenylate cyclase activity" EXACT [] synonym: "inhibition of adenylate cyclase activity" NARROW [] synonym: "negative regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity [Term] id: GO:0007195 name: adenylate cyclase-inhibiting dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway [Term] id: GO:0007196 name: adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "adenylate cyclase-inhibiting G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by G-protein-coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0007197 name: adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" RELATED [GOC:mah] synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0007198 name: adenylate cyclase-inhibiting serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" RELATED [] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway [Term] id: GO:0007199 name: G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase (GC) activity and a subsequent increase in the concentration of cyclic GMP (cGMP)." [GOC:mah, GOC:signaling, ISBN:0815316194] synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cGMP nucleotide second messenger" EXACT [GOC:signaling] synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "GPCR signaling pathway via activation of guanylate cyclase activity" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via cGMP second messenger" EXACT [GOC:signaling] synonym: "guanylate cyclase-activating G-protein coupled receptor signaling pathway" EXACT [GOC:signaling] is_a: GO:0007187 ! G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger [Term] id: GO:0007200 name: phospholipase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent increase in the concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) activity. synonym: "activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger" RELATED [GOC:signaling] synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G-protein coupled receptor signaling pathway coupled to IP3 second messenger" EXACT [GOC:signaling] synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "phospholipase C-activating dopamine receptor signaling pathway" NARROW [GOC:dph, GOC:tb] synonym: "phospholipase C-activating G-protein coupled receptor signaling pathway" EXACT [] synonym: "PLC-activating GPCR signaling pathway" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007201 name: obsolete G-protein dissociation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. synonym: "G-protein dissociation" EXACT [] is_obsolete: true [Term] id: GO:0007202 name: activation of phospholipase C activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010863 ! positive regulation of phospholipase C activity [Term] id: GO:0007203 name: obsolete phosphatidylinositol-4,5-bisphosphate hydrolysis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction, not a process. synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" EXACT [] is_obsolete: true consider: GO:0004435 [Term] id: GO:0007204 name: positive regulation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] synonym: "cytosolic calcium ion concentration elevation" EXACT [] synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] synonym: "elevation of calcium ion concentration in cytosol" EXACT [] synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] synonym: "elevation of cytosolic calcium ion concentration" EXACT [] is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0007205 name: protein kinase C-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG)." [GOC:mah, GOC:signaling] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" RELATED [GOC:mah] synonym: "protein kinase C-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007206 name: phospholipase C-activating G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled glutamate receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by G-protein coupled glutamate receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway" RELATED [GOC:bf] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" RELATED [GOC:mah] synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "phospholipase C-activating G-protein coupled glutamate receptor signaling pathway" RELATED [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007216 ! G protein-coupled glutamate receptor signaling pathway [Term] id: GO:0007207 name: phospholipase C-activating G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled acetylcholine receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by G-protein coupled acetylcholine receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway" RELATED [GOC:bf] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "muscarinic receptor signaling pathway via activation of PLC" EXACT [GOC:signaling] synonym: "phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway" EXACT [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007213 ! G protein-coupled acetylcholine receptor signaling pathway [Term] id: GO:0007208 name: phospholipase C-activating serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by serotonin receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" RELATED [GOC:mah] synonym: "serotonin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0098664 ! G protein-coupled serotonin receptor signaling pathway [Term] id: GO:0007209 name: phospholipase C-activating tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "activation of phospholipase C activity by tachykinin receptor signaling pathway" RELATED [GOC:signaling] synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" RELATED [GOC:mah] synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0007210 name: serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "serotonin receptor signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0007211 name: octopamine or tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of octopamine or tyramine binding to a cell surface receptor. Octopamine and tyramine are decarboxylation products of tyrosine, and are the invertebrate counterparts of the vertebrate adrenergic transmitters." [GOC:mah, PMID:15355245] synonym: "octopamine or tyramine signalling pathway" EXACT [GOC:mah] synonym: "octopamine/tyramine signaling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007212 name: dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "dopamine receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007213 name: G protein-coupled acetylcholine receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by an acetylcholine receptor on the surface of the target cell binding to one of its physiological ligands, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction and ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] synonym: "G-protein coupled acetylcholine receptor signaling pathway" EXACT [] synonym: "muscarinic acetylcholine receptor signaling pathway" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0095500 ! acetylcholine receptor signaling pathway [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007215 name: glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of glutamate to a glutamate receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "glutamate signaling pathway" EXACT [GOC:bf] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007216 name: G protein-coupled glutamate receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, and proceeding with the activated receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. Ends with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:9131252] synonym: "G-protein coupled glutamate receptor signaling pathway" EXACT [] synonym: "metabotropic glutamate receptor signaling pathway" EXACT [GOC:bf] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007215 ! glutamate receptor signaling pathway [Term] id: GO:0007217 name: tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] synonym: "tachykinin signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0007219 name: Notch signaling pathway namespace: biological_process alt_id: GO:0030179 def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Notch on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, GOC:signaling] synonym: "N signaling pathway" EXACT [] synonym: "N signalling pathway" EXACT [] synonym: "Notch receptor signaling pathway" EXACT [] synonym: "Notch receptor signalling pathway" EXACT [] synonym: "Notch signalling pathway" EXACT [] synonym: "Notch-receptor signaling pathway" EXACT [] synonym: "Notch-receptor signalling pathway" EXACT [] xref: Wikipedia:Notch_signaling_pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007220 name: Notch receptor processing namespace: biological_process def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] synonym: "N receptor processing" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0007221 name: positive regulation of transcription of Notch receptor target namespace: biological_process def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] synonym: "N receptor target transcription factor activation" RELATED [] synonym: "Notch receptor target transcription factor activation" RELATED [] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: part_of GO:0007219 ! Notch signaling pathway [Term] id: GO:0007223 name: Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled-2 signaling pathway" NARROW [] synonym: "frizzled-2 signalling pathway" NARROW [] synonym: "non-canonical Wnt signaling pathway" RELATED [] synonym: "Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] is_a: GO:0035567 ! non-canonical Wnt signaling pathway [Term] id: GO:0007224 name: smoothened signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] synonym: "hedgehog signaling pathway" EXACT [] synonym: "hh signaling pathway" NARROW [] synonym: "hh signalling pathway" NARROW [] synonym: "Shh signaling pathway" RELATED [GOC:dph] synonym: "smoothened signalling pathway" EXACT [] synonym: "Sonic hedgehog signaling pathway" NARROW [GOC:dph] xref: Wikipedia:Hedgehog_signaling_pathway is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007225 name: patched ligand maturation namespace: biological_process def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol groups." [PMID:15057936] synonym: "Hedgehog protein processing" NARROW [] synonym: "hh protein processing" EXACT [] synonym: "patched ligand processing" RELATED [] is_a: GO:0035638 ! signal maturation is_a: GO:0051604 ! protein maturation relationship: part_of GO:0045880 ! positive regulation of smoothened signaling pathway [Term] id: GO:0007227 name: signal transduction downstream of smoothened namespace: biological_process def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] is_a: GO:0035556 ! intracellular signal transduction relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0007228 name: positive regulation of hh target transcription factor activity namespace: biological_process def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd] is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity relationship: part_of GO:0007227 ! signal transduction downstream of smoothened [Term] id: GO:0007229 name: integrin-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of extracellular ligand to an integrin on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling] synonym: "integrin-mediated signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0007230 name: obsolete calcium-o-sensing receptor pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not make sense. synonym: "calcium-o-sensing receptor pathway" EXACT [] is_obsolete: true consider: GO:0019722 [Term] id: GO:0007231 name: osmosensory signaling pathway namespace: biological_process def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] synonym: "osmolarity sensing" EXACT [] synonym: "osmolarity sensing signaling pathway" EXACT [] synonym: "osmolarity sensing signalling pathway" EXACT [] synonym: "osmosensory signal transduction" EXACT [GOC:signaling] synonym: "osmosensory signalling pathway" EXACT [] synonym: "signal transduction during osmotic stress" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0007232 name: osmosensory signaling pathway via Sho1 osmosensor namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007234 name: osmosensory signaling via phosphorelay pathway namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a phosphorelay system." [PMID:9843501] synonym: "osmolarity sensing via two-component system" EXACT [] synonym: "osmolarity signaling pathway via two-component system" EXACT [] synonym: "osmolarity signalling pathway via two-component system" EXACT [] synonym: "osmosensory signaling pathway via two-component system" NARROW [] synonym: "osmosensory signalling pathway via two-component system" EXACT [] synonym: "signal transduction during osmotic stress via two-component system" EXACT [] is_a: GO:0000160 ! phosphorelay signal transduction system is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007235 name: obsolete activation of Ypd1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ypd1 protein" EXACT [] is_obsolete: true [Term] id: GO:0007236 name: obsolete activation of Ssk1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ssk1 protein" EXACT [] is_obsolete: true [Term] id: GO:0007237 name: obsolete activation of Ssk2/Ssk22 proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Ssk2/Ssk22 proteins" EXACT [] is_obsolete: true [Term] id: GO:0007238 name: obsolete activation of Pbs2 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Pbs2" EXACT [] is_obsolete: true [Term] id: GO:0007239 name: obsolete activation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "activation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007240 name: obsolete nuclear translocation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "nuclear translocation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007241 name: obsolete inactivation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. synonym: "inactivation of Hog1" EXACT [] is_obsolete: true [Term] id: GO:0007244 name: obsolete MAPKKK cascade (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007245 name: obsolete activation of MAPKKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007246 name: obsolete activation of MAPKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007247 name: obsolete activation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0000750 [Term] id: GO:0007248 name: obsolete nuclear translocation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (mating sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007249 name: I-kappaB kinase/NF-kappaB signaling namespace: biological_process def: "The process in which a signal is passed on to downstream components within the cell through the I-kappaB-kinase (IKK)-dependent activation of NF-kappaB. The cascade begins with activation of a trimeric IKK complex (consisting of catalytic kinase subunits IKKalpha and/or IKKbeta, and the regulatory scaffold protein NEMO) and ends with the regulation of transcription of target genes by NF-kappaB. In a resting state, NF-kappaB dimers are bound to I-kappaB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:12773372, Reactome:R-HSA-209560] synonym: "activation of the inhibitor of kappa kinase" RELATED [] synonym: "canonical NF-kappaB signaling cascade" EXACT [GOC:bf] synonym: "I-kappaB kinase/NF-kappaB cascade" RELATED [GOC:signaling] synonym: "I-kappaB kinase/NF-kappaB signal transduction" EXACT [GOC:signaling] synonym: "NF-kappaB cascade" BROAD [] synonym: "p50-dependent NF-kappaB signaling" RELATED [PMID:18292232] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007250 name: activation of NF-kappaB-inducing kinase activity namespace: biological_process def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] synonym: "activation of NIK activity" EXACT [GOC:bf] synonym: "positive regulation of NF-kappaB-inducing kinase activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:1901224 ! positive regulation of NIK/NF-kappaB signaling relationship: part_of GO:0038061 ! NIK/NF-kappaB signaling [Term] id: GO:0007251 name: obsolete activation of the inhibitor of kappa kinase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its meaning was unclear. synonym: "activation of the inhibitor of kappa kinase" EXACT [] is_obsolete: true consider: GO:0007249 [Term] id: GO:0007252 name: I-kappaB phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into an inhibitor of kappa B (I-kappaB) protein. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing bound NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:jl, PMID:21772278, PMID:7594468] synonym: "IkappaB phosphorylation" EXACT [GOC:bf] synonym: "IKB phosphorylation" EXACT [GOC:bf] synonym: "inhibitor of kappaB phosphorylation" EXACT [GOC:bf] synonym: "inhibitor of NF-kappaB phosphorylation" EXACT [GOC:bf] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB signaling [Term] id: GO:0007253 name: cytoplasmic sequestering of NF-kappaB namespace: biological_process def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic NF-kappaB retention" EXACT [] synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] synonym: "cytoplasmic NF-kappaB storage" EXACT [] synonym: "cytoplasmic retention of NF-kappaB" EXACT [] synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] synonym: "cytoplasmic storage of NF-kappaB" EXACT [] synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] is_a: GO:0032088 ! negative regulation of NF-kappaB transcription factor activity is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor [Term] id: GO:0007254 name: JNK cascade namespace: biological_process def: "An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell." [GOC:bf, GOC:signaling, PMID:11790549, PMID:20811974] synonym: "c-Jun N-terminal kinase cascade" EXACT [PMID:20811974] synonym: "JNK1 cascade" NARROW [GOC:add] synonym: "JNK2 cascade" NARROW [GOC:add] synonym: "JNK3 cascade" NARROW [GOC:add] synonym: "MAPK10 cascade" NARROW [GOC:add] synonym: "MAPK8 cascade" NARROW [GOC:add] synonym: "MAPK9 cascade" NARROW [GOC:add] synonym: "SAPK cascade" BROAD [] synonym: "stress-activated protein kinase cascade" BROAD [] is_a: GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0007256 name: activation of JNKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "activation of JUN kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKK activity" BROAD [] is_a: GO:0000186 ! activation of MAPKK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007257 name: activation of JUN kinase activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase (JNK)." [GOC:bf] synonym: "activation of SAPK activity" BROAD [] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007258 name: JUN phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007259 name: receptor signaling pathway via JAK-STAT namespace: biological_process def: "Any process in which STAT proteins (Signal Transducers and Activators of Transcription) and JAK (Janus Activated Kinase) proteins convey a signal to trigger a change in the activity or state of a cell. The receptor signaling pathway via JAK-STAT begins with activation of a receptor and proceeeds through STAT protein activation by members of the JAK family of tyrosine kinases. STAT proteins dimerize and subsequently translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins." [GOC:bf, GOC:jl, GOC:signaling, PMID:12039028] synonym: "JAK-STAT cascade" NARROW [] synonym: "JAK-STAT signal transduction" EXACT [GOC:signaling] xref: Wikipedia:JAK-STAT_signaling_pathway is_a: GO:0097696 ! receptor signaling pathway via STAT [Term] id: GO:0007260 name: tyrosine phosphorylation of STAT protein namespace: biological_process alt_id: GO:0042502 alt_id: GO:0042503 alt_id: GO:0042504 alt_id: GO:0042505 alt_id: GO:0042506 alt_id: GO:0042507 alt_id: GO:0042508 def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] synonym: "tyrosine phosphorylation of Stat1 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat2 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat3 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat4 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat5 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat6 protein" NARROW [] synonym: "tyrosine phosphorylation of Stat7 protein" NARROW [] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: part_of GO:0007259 ! receptor signaling pathway via JAK-STAT [Term] id: GO:0007261 name: obsolete JAK-induced STAT protein dimerization namespace: biological_process def: "OBSOLETE. The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] comment: This term was made obsolete because it is ambiguous, and protein dimerization is represented by molecular function terms. synonym: "JAK-induced STAT protein dimerization" EXACT [] is_obsolete: true consider: GO:0007260 consider: GO:0046983 [Term] id: GO:0007263 name: nitric oxide mediated signal transduction namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via nitric oxide (NO). Includes synthesis of nitric oxide, receptors/sensors for nitric oxide (such as soluble guanylyl cyclase/sGC) and downstream effectors that further transmit the signal within the cell. Nitric oxide transmits its downstream effects through either cyclic GMP (cGMP)-dependent or independent mechanisms." [GOC:jl, PMID:21549190] synonym: "nitric oxide signaling" EXACT [GOC:bf] synonym: "nitric oxide-mediated signal transduction" EXACT [] synonym: "NO mediated signal transduction" EXACT [] synonym: "NO-mediated signal transduction" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0007264 name: small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] synonym: "small GTPase-mediated signal transduction" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007265 name: Ras protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Ras mediated signal transduction" EXACT [] is_a: GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0007266 name: Rho protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rho mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another. This process includes signal transduction in the receiving cell and, where applicable, release of a ligand and any processes that actively facilitate its transport and presentation to the receiving cell. Examples include signaling via soluble ligands, via cell adhesion molecules and via gap junctions." [GOC:dos, GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "cell-cell signalling" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: chemical synaptic transmission namespace: biological_process def: "The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:jl, MeSH:D009435] subset: goslim_synapse synonym: "neurotransmission" RELATED [GOC:dph] synonym: "signal transmission across a synapse" BROAD [] synonym: "synaptic transmission" BROAD [] xref: Wikipedia:Neurotransmission is_a: GO:0098916 ! anterograde trans-synaptic signaling [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process alt_id: GO:0010554 def: "The regulated release of neurotransmitter from the presynapse into the synaptic cleft via calcium-regulated exocytosis during synaptic transmission." [CHEBI:25512, GOC:dph] comment: A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin. subset: goslim_synapse synonym: "neurotransmitter release" EXACT [] synonym: "neurotransmitter secretory pathway" EXACT [] is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0051649 ! establishment of localization in cell is_a: GO:0099643 ! signal release from synapse relationship: part_of GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007270 name: neuron-neuron synaptic transmission namespace: biological_process def: "The process of synaptic transmission from a neuron to another neuron across a synapse." [GOC:add, GOC:dos, GOC:jl, MeSH:D009435] synonym: "nerve-nerve synaptic transmission" RELATED [] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The vesicular release of acetylcholine from a presynapse, across a chemical synapse, the subsequent activation of dopamine receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse." [GOC:dos, Wikipedia:Cholinergic] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process in which glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007273 name: obsolete regulation of synapse namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string made no sense. synonym: "regulation of synapse" EXACT [] is_obsolete: true consider: GO:0007268 [Term] id: GO:0007274 name: neuromuscular synaptic transmission namespace: biological_process def: "The process of synaptic transmission from a neuron to a muscle, across a synapse." [GOC:dos, GOC:jl, MeSH:D009435] is_a: GO:0007268 ! chemical synaptic transmission [Term] id: GO:0007275 name: multicellular organism development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_chembl subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007277 name: pole cell development namespace: biological_process def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007278 name: pole cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007279 name: pole cell formation namespace: biological_process def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007280 name: pole cell migration namespace: biological_process def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0008354 ! germ cell migration [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048468 ! cell development relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007282 name: cystoblast division namespace: biological_process def: "Any of the rounds of incomplete mitosis undergone by a cystoblast to form a cyst of interconnected cells." [PMID:21452446] synonym: "cystoblast cell division" EXACT [] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, ISBN:9780878933846] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form secondary spermatogonia (primary spermatocytes)." [GOC:bf, GOC:pr, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. synonym: "spermatogonium division" EXACT [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0051301 ! cell division relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007285 name: primary spermatocyte growth namespace: biological_process def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007287 name: Nebenkern assembly namespace: biological_process def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238] comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. synonym: "nebenkern assembly" EXACT [PMID:9550716] synonym: "Nebenkern formation" RELATED [GOC:dph] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007005 ! mitochondrion organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, GOC:cilia, ISBN:0198547684] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0035082 ! axoneme assembly relationship: part_of GO:0007286 ! spermatid development relationship: part_of GO:0030317 ! flagellated sperm motility [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007290 name: spermatid nucleus elongation namespace: biological_process def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "spermatid nuclear elongation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0007291 name: sperm individualization namespace: biological_process def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007349 ! cellularization relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007294 name: germarium-derived oocyte fate determination namespace: biological_process alt_id: GO:0016350 def: "The cell fate determination process in which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maintenance of oocyte identity" RELATED [] synonym: "oocyte cell fate determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030716 ! oocyte fate determination relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation [Term] id: GO:0007295 name: growth of a germarium-derived egg chamber namespace: biological_process def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "egg chamber growth" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007296 name: vitellogenesis namespace: biological_process def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] synonym: "yolk formation" EXACT [] synonym: "yolk production" EXACT systematic_synonym [] xref: Wikipedia:Vitellogenesis is_a: GO:0007028 ! cytoplasm organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007297 name: ovarian follicle cell migration namespace: biological_process def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "follicle cell migration" BROAD [] is_a: GO:0010631 ! epithelial cell migration is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007298 name: border follicle cell migration namespace: biological_process def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "border cell migration" BROAD [] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0007299 name: ovarian follicle cell-cell adhesion namespace: biological_process def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] synonym: "follicle cell adhesion" BROAD [] synonym: "ovarian follicle cell adhesion" EXACT [GOC:curators] is_a: GO:0022414 ! reproductive process is_a: GO:0090136 ! epithelial cell-cell adhesion relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007300 name: ovarian nurse cell to oocyte transport namespace: biological_process def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "nurse cell to oocyte transport" BROAD [] is_a: GO:0006810 ! transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007301 name: female germline ring canal formation namespace: biological_process def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] synonym: "nurse cell ring canal formation" NARROW [] synonym: "ovarian ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007302 name: nurse cell nucleus anchoring namespace: biological_process def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] is_a: GO:0051647 ! nucleus localization [Term] id: GO:0007303 name: cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] is_a: GO:0016482 ! cytosolic transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007304 name: chorion-containing eggshell formation namespace: biological_process def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "eggshell formation" BROAD [] is_a: GO:0030703 ! eggshell formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007305 name: vitelline membrane formation involved in chorion-containing eggshell formation namespace: biological_process def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "vitelline membrane formation in chorion-containing eggshell" EXACT [GOC:dph, GOC:tb] is_a: GO:0030704 ! vitelline membrane formation relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007306 name: eggshell chorion assembly namespace: biological_process def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb] synonym: "insect chorion formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007307 name: eggshell chorion gene amplification namespace: biological_process def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] is_a: GO:0006277 ! DNA amplification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0007308 name: oocyte construction namespace: biological_process alt_id: GO:0048110 def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0048469 ! cell maturation relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0007309 name: oocyte axis specification namespace: biological_process alt_id: GO:0048111 def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte axis determination" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0007310 name: oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008072 alt_id: GO:0048123 def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007311 name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded namespace: biological_process alt_id: GO:0048124 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007312 name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008102 alt_id: GO:0030722 alt_id: GO:0048126 alt_id: GO:0048128 def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "establishment of localization of oocyte nucleus during oocyte axis determination" BROAD [] synonym: "establishment of oocyte nucleus localisation involved in oocyte dorsal/ventral axis specification" RELATED [GOC:mah] synonym: "establishment of oocyte nucleus localization during oocyte axis determination" BROAD [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal-ventral axis specification" RELATED [GOC:mah] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification" RELATED [] synonym: "establishment of oocyte nucleus localization involved in oocyte dorsoventral axis specification" RELATED [GOC:mah] synonym: "nucleus positioning in oocyte during oocyte axis determination" BROAD [] synonym: "oocyte axis determination, establishment of localization of nucleus" BROAD [] synonym: "oocyte axis determination, establishment of oocyte nucleus localization" BROAD [] synonym: "oocyte axis determination, establishment of position of nucleus" BROAD [] synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] synonym: "oocyte axis determination, positioning of nucleus" BROAD [] synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb] synonym: "oocyte nucleus positioning during oocyte axis determination" BROAD [] is_a: GO:0007097 ! nuclear migration is_a: GO:0051663 ! oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [Term] id: GO:0007313 name: maternal specification of dorsal/ventral axis, oocyte, soma encoded namespace: biological_process alt_id: GO:0048125 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007314 name: oocyte anterior/posterior axis specification namespace: biological_process alt_id: GO:0048112 def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo [Term] id: GO:0007315 name: pole plasm assembly namespace: biological_process alt_id: GO:0048113 def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] is_a: GO:0007028 ! cytoplasm organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0007316 name: pole plasm RNA localization namespace: biological_process alt_id: GO:0048116 def: "Any process in which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] synonym: "oocyte pole plasm RNA localization" EXACT [] synonym: "pole plasm RNA localisation" EXACT [GOC:mah] is_a: GO:0006403 ! RNA localization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007317 name: regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] synonym: "regulation of pole plasm oskar mRNA localisation" EXACT [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1902875 ! regulation of embryonic pattern specification is_a: GO:1903429 ! regulation of cell maturation is_a: GO:1904580 ! regulation of intracellular mRNA localization relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0007318 name: pole plasm protein localization namespace: biological_process alt_id: GO:0048115 def: "Any process in which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] synonym: "oocyte pole plasm protein localization" EXACT [] synonym: "pole plasm protein localisation" EXACT [GOC:mah] is_a: GO:0008104 ! protein localization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007319 name: negative regulation of oskar mRNA translation namespace: biological_process def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] synonym: "down regulation of oskar mRNA translation" EXACT [] synonym: "down-regulation of oskar mRNA translation" EXACT [] synonym: "downregulation of oskar mRNA translation" EXACT [] synonym: "inhibition of oskar mRNA translation" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0007320 name: insemination namespace: biological_process def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] xref: Wikipedia:Insemination is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007620 ! copulation [Term] id: GO:0007321 name: sperm displacement namespace: biological_process def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0007323 name: peptide pheromone maturation namespace: biological_process alt_id: GO:0007324 alt_id: GO:0007326 alt_id: GO:0046613 def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "pheromone processing" EXACT [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0007329 name: positive regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] is_a: GO:0009371 ! positive regulation of transcription by pheromones is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [Term] id: GO:0007336 name: obsolete bilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. synonym: "bilateral process" EXACT [] is_obsolete: true [Term] id: GO:0007337 name: obsolete unilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. synonym: "unilateral process" EXACT [] is_obsolete: true [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" RELATED [] synonym: "zygote formation" RELATED [] is_a: GO:0009566 ! fertilization [Term] id: GO:0007339 name: binding of sperm to zona pellucida namespace: biological_process def: "The process in which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] synonym: "ZPG binding" RELATED [] is_a: GO:0035036 ! sperm-egg recognition [Term] id: GO:0007340 name: acrosome reaction namespace: biological_process def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida." [GOC:dph, PMID:11175768, PMID:21042299, PMID:3886029] comment: If the release of the acrosome content occurs before the sperm reaches the zona pellucida, consider using premature acrosome loss. xref: Wikipedia:Acrosome_reaction is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007341 name: penetration of zona pellucida namespace: biological_process def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007342 name: fusion of sperm to egg plasma membrane involved in single fertilization namespace: biological_process def: "The binding and fusion of a sperm, with the plasma membrane of the oocyte as part of the process of single fertilization. In sperm with flagella, binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:dph, GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "sperm-oocyte fusion" NARROW [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process in which the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007344 name: pronuclear fusion namespace: biological_process def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] is_a: GO:0000741 ! karyogamy is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007345 name: obsolete embryogenesis and morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. synonym: "embryogenesis and morphogenesis" EXACT [] is_obsolete: true consider: GO:0009653 consider: GO:0009790 [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007347 name: regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0007348 name: regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "syncytial blastoderm cell cycle modulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulator" RELATED [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0022402 ! cell cycle process relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0007349 name: cellularization namespace: biological_process alt_id: GO:0009796 def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation [Term] id: GO:0007351 name: tripartite regional subdivision namespace: biological_process def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007352 name: zygotic specification of dorsal/ventral axis namespace: biological_process def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah] synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph] synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007353 name: obsolete ventral/lateral system namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. synonym: "ventral/lateral system" EXACT [] is_obsolete: true consider: GO:0009880 [Term] id: GO:0007354 name: zygotic determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0007355 name: anterior region determination namespace: biological_process def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007356 name: thorax and anterior abdomen determination namespace: biological_process def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007357 name: positive regulation of central gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of central gap gene" BROAD [] synonym: "activation of central gap gene transcription" NARROW [] synonym: "stimulation of central gap gene transcription" NARROW [] synonym: "up regulation of central gap gene transcription" EXACT [] synonym: "up-regulation of central gap gene transcription" EXACT [] synonym: "upregulation of central gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007358 name: establishment of central gap gene boundaries namespace: biological_process def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007359 name: posterior abdomen determination namespace: biological_process def: "The regionalization process in which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: Note that this process is exemplified in insects by the actions of the knirps gene product. is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007360 name: positive regulation of posterior gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of posterior gap gene" BROAD [] synonym: "activation of posterior gap gene transcription" NARROW [] synonym: "knirps activation" NARROW [] synonym: "stimulation of posterior gap gene transcription" NARROW [] synonym: "up regulation of posterior gap gene transcription" EXACT [] synonym: "up-regulation of posterior gap gene transcription" EXACT [] synonym: "upregulation of posterior gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007361 name: establishment of posterior gap gene boundaries namespace: biological_process def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007362 name: terminal region determination namespace: biological_process def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007363 name: positive regulation of terminal gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of terminal gap gene" BROAD [] synonym: "activation of terminal gap gene transcription" NARROW [] synonym: "stimulation of terminal gap gene transcription" NARROW [] synonym: "up regulation of terminal gap gene transcription" EXACT [] synonym: "up-regulation of terminal gap gene transcription" EXACT [] synonym: "upregulation of terminal gap gene transcription" EXACT [] is_a: GO:0044324 ! regulation of transcription involved in anterior/posterior axis specification is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007364 name: establishment of terminal gap gene boundary namespace: biological_process def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007365 name: periodic partitioning namespace: biological_process def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] comment: Note that examples of periodic partitions are tagmata, segments or parasegments. is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007366 name: periodic partitioning by pair rule gene namespace: biological_process def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007367 name: segment polarity determination namespace: biological_process def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007368 name: determination of left/right symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] synonym: "determination of left/right asymmetry" EXACT [GOC:dph] is_a: GO:0009855 ! determination of bilateral symmetry [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [GOC:curators, ISBN:9780878933846] xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0007370 name: ventral furrow formation namespace: biological_process def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007371 name: ventral midline determination namespace: biological_process alt_id: GO:0007372 alt_id: GO:0007373 def: "The regionalization process in which the area where the ventral midline will form is specified." [GOC:bf, GOC:isa_complete, GOC:vk] synonym: "determination of anterior border of ventral midline" NARROW [] synonym: "determination of posterior border of ventral midline" NARROW [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007418 ! ventral midline development [Term] id: GO:0007374 name: posterior midgut invagination namespace: biological_process def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007375 name: anterior midgut invagination namespace: biological_process def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007376 name: cephalic furrow formation namespace: biological_process def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007377 name: germ-band extension namespace: biological_process def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007378 name: amnioserosa formation namespace: biological_process def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007379 name: segment specification namespace: biological_process def: "The process in which segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0035282 ! segmentation [Term] id: GO:0007380 name: specification of segmental identity, head namespace: biological_process def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035287 ! head segmentation [Term] id: GO:0007381 name: specification of segmental identity, labial segment namespace: biological_process def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007382 name: specification of segmental identity, maxillary segment namespace: biological_process def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007383 name: specification of segmental identity, antennal segment namespace: biological_process def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0007384 name: specification of segmental identity, thorax namespace: biological_process def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007385 name: specification of segmental identity, abdomen namespace: biological_process def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007386 name: compartment pattern specification namespace: biological_process def: "The regionalization process in which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "compartment specification" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007387 name: anterior compartment pattern formation namespace: biological_process def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior compartment pattern specification" RELATED [GOC:dph] is_a: GO:0007386 ! compartment pattern specification [Term] id: GO:0007388 name: posterior compartment specification namespace: biological_process def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007386 ! compartment pattern specification [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007390 name: germ-band shortening namespace: biological_process def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] synonym: "germ-band retraction" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007391 name: dorsal closure namespace: biological_process def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007392 name: initiation of dorsal closure namespace: biological_process def: "Events that occur at the start of dorsal closure." [GOC:bf] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007393 name: dorsal closure, leading edge cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] is_a: GO:0035028 ! leading edge cell fate determination relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment [Term] id: GO:0007394 name: dorsal closure, elongation of leading edge cells namespace: biological_process def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0016476 ! regulation of embryonic cell shape is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0007395 name: dorsal closure, spreading of leading edge cells namespace: biological_process def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] is_a: GO:0016477 ! cell migration relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007396 name: suture of dorsal opening namespace: biological_process def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007397 name: obsolete histogenesis and organogenesis namespace: biological_process def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] comment: This term was made obsolete because more appropriate terms were created. synonym: "histogenesis and organogenesis" EXACT [] is_obsolete: true consider: GO:0009887 consider: GO:0009888 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] synonym: "pan-neural process" RELATED [] is_a: GO:0048731 ! system development [Term] id: GO:0007400 name: neuroblast fate determination namespace: biological_process alt_id: GO:0007408 alt_id: GO:0043347 alt_id: GO:0043348 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "neuroblast cell fate determination" EXACT [] synonym: "neuroblast identity determination" EXACT [] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0007401 name: obsolete pan-neural process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because its meaning is ambiguous. synonym: "pan-neural process" EXACT [] is_obsolete: true consider: GO:0007399 consider: GO:0050877 [Term] id: GO:0007402 name: ganglion mother cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0048867 ! stem cell fate determination [Term] id: GO:0007403 name: glial cell fate determination namespace: biological_process alt_id: GO:0043361 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process alt_id: GO:0043349 alt_id: GO:0043350 def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0061351 ! neural precursor cell proliferation is_a: GO:0072089 ! stem cell proliferation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0050768 ! negative regulation of neurogenesis is_a: GO:1902692 ! regulation of neuroblast proliferation is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation is_a: GO:2000647 ! negative regulation of stem cell proliferation relationship: negatively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process alt_id: GO:0043351 alt_id: GO:0043352 def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001775 ! cell activation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007409 name: axonogenesis namespace: biological_process alt_id: GO:0007410 def: "De novo generation of a long process of a neuron, including the terminal branched region. Refers to the morphogenesis or creation of shape or form of the developing axon, which carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:dph, GOC:jid, GOC:pg, GOC:pr, ISBN:0198506732] comment: Note that 'axonogenesis' differs from 'axon development' in that the latter also covers other processes, such as axon regeneration (regrowth after loss or damage, not necessarily of the whole axon). synonym: "axon growth" NARROW [] synonym: "axon morphogenesis" EXACT [GOC:bf, PMID:23517308] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007411 name: axon guidance namespace: biological_process alt_id: GO:0008040 def: "The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "axon chemotaxis" RELATED [GOC:curators] synonym: "axon growth cone guidance" NARROW [] synonym: "axon pathfinding" EXACT [GOC:mah] xref: Wikipedia:Axon_guidance is_a: GO:0097485 ! neuron projection guidance relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007412 name: axon target recognition namespace: biological_process def: "The process in which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] is_a: GO:0007154 ! cell communication relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007413 name: axonal fasciculation namespace: biological_process def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] synonym: "fasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition is_a: GO:0106030 ! neuron projection fasciculation relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007414 name: axonal defasciculation namespace: biological_process def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] synonym: "defasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0061564 ! axon development [Term] id: GO:0007415 name: defasciculation of motor neuron axon namespace: biological_process def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] is_a: GO:0007414 ! axonal defasciculation [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional)." [GOC:mah] subset: goslim_synapse synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0022607 ! cellular component assembly is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007419 name: ventral cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0060322 ! head development [Term] id: GO:0007421 name: stomatogastric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, UBERON:0000010] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! animal organ development [Term] id: GO:0007424 name: open tracheal system development namespace: biological_process def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. is_a: GO:0060541 ! respiratory system development [Term] id: GO:0007425 name: epithelial cell fate determination, open tracheal system namespace: biological_process alt_id: GO:0046846 def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] synonym: "tracheal cell fate determination" BROAD [] synonym: "tracheal epithelial cell fate determination" EXACT [] synonym: "tracheal placode cell fate determination" RELATED [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007426 name: tracheal outgrowth, open tracheal system namespace: biological_process def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007427 name: epithelial cell migration, open tracheal system namespace: biological_process def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal cell migration" BROAD [] synonym: "tracheal epithelial cell migration" RELATED [] is_a: GO:0010631 ! epithelial cell migration relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007428 name: primary branching, open tracheal system namespace: biological_process def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "primary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007429 name: secondary branching, open tracheal system namespace: biological_process def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "secondary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007430 name: terminal branching, open tracheal system namespace: biological_process def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007431 name: salivary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, UBERON:0001044] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0007432 name: salivary gland boundary specification namespace: biological_process def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] synonym: "salivary gland determination" EXACT [] is_a: GO:0010160 ! formation of animal organ boundary relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007433 name: larval salivary gland boundary specification namespace: biological_process def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007434 name: adult salivary gland boundary specification namespace: biological_process def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification [Term] id: GO:0007435 name: salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007436 name: larval salivary gland morphogenesis namespace: biological_process def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized." [GOC:jid] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007437 name: adult salivary gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the adult salivary gland are generated and organized." [GOC:go_curators] is_a: GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0007438 name: oenocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] is_a: GO:0048468 ! cell development relationship: part_of GO:0001742 ! oenocyte differentiation [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:curators] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the foregut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007441 name: anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the anterior midgut (ectodermal) are generated and organized." [GOC:go_curators] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hindgut are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis relationship: part_of GO:0061525 ! hindgut development [Term] id: GO:0007443 name: Malpighian tubule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0061333 ! renal tubule morphogenesis relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis relationship: part_of GO:0072002 ! Malpighian tubule development [Term] id: GO:0007444 name: imaginal disc development namespace: biological_process def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, ISBN:0879694238] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development is_a: GO:0060429 ! epithelium development [Term] id: GO:0007445 name: determination of imaginal disc primordium namespace: biological_process def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007446 name: imaginal disc growth namespace: biological_process def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] is_a: GO:0035265 ! organ growth relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007447 name: imaginal disc pattern formation namespace: biological_process def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007448 name: anterior/posterior pattern specification, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0007449 name: proximal/distal pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0007450 name: dorsal/ventral pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, ISBN:0879694238] synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0007451 name: dorsal/ventral lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc [Term] id: GO:0007453 name: clypeo-labral disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the clypeo-labral disc are generated and organized. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] synonym: "clypeo-labral disc metamorphosis" EXACT [] synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0007454 name: labial disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the labial disc are generated and organized. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] synonym: "labial disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035217 ! labial disc development [Term] id: GO:0007455 name: eye-antennal disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the eye-antennal disc are generated and organized. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] synonym: "eye-antennal disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007458 name: progression of morphogenetic furrow involved in compound eye morphogenesis namespace: biological_process def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0007460 name: R8 cell fate commitment namespace: biological_process alt_id: GO:0007461 def: "The process in which the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] synonym: "restriction of R8 fate" EXACT [] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0007462 name: R1/R6 cell fate commitment namespace: biological_process def: "The process in which the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0007463 name: R2/R5 cell fate commitment namespace: biological_process def: "The process in which the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0007464 name: R3/R4 cell fate commitment namespace: biological_process def: "The process in which the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0007465 name: R7 cell fate commitment namespace: biological_process def: "The process in which the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0007468 name: regulation of rhodopsin gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0007469 name: antennal development namespace: biological_process def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007470 name: prothoracic disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the prothoracic disc are generated and organized. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] synonym: "prothoracic disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035219 ! prothoracic disc development [Term] id: GO:0007471 name: obsolete prothoracic morphogenesis namespace: biological_process def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized." [GOC:jid] comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. synonym: "prothoracic morphogenesis" EXACT [] is_obsolete: true consider: GO:0007470 [Term] id: GO:0007472 name: wing disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the wing disc are generated and organized. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] synonym: "wing disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007473 name: wing disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0007474 name: imaginal disc-derived wing vein specification namespace: biological_process def: "The regionalization process in which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] synonym: "wing vein specification" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0007475 name: apposition of dorsal and ventral imaginal disc-derived wing surfaces namespace: biological_process def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis [Term] id: GO:0007476 name: imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing are generated and organized. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] synonym: "wing morphogenesis" EXACT [] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis [Term] id: GO:0007477 name: notum development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007478 name: leg disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the leg disc are generated and organized. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] synonym: "leg disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0007479 name: leg disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0007480 name: imaginal disc-derived leg morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a leg derived from an imaginal disc are generated and organized. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007478 ! leg disc morphogenesis [Term] id: GO:0007481 name: haltere disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the haltere disc are generated and organized. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] synonym: "haltere disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007482 name: haltere development namespace: biological_process def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] is_a: GO:0048737 ! imaginal disc-derived appendage development relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007483 name: genital disc morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the genital disc are generated and organized. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] synonym: "genital disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007484 name: imaginal disc-derived genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "genital development" BROAD [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007485 name: imaginal disc-derived male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "male genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0007486 name: imaginal disc-derived female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "female genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development is_a: GO:0030540 ! female genitalia development [Term] id: GO:0007487 name: analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007488 name: histoblast morphogenesis namespace: biological_process def: "The process in which the anatomical structures derived from the histoblast disc are generated and organized. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] synonym: "histoblast metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007489 name: maintenance of imaginal histoblast diploidy namespace: biological_process def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007490 name: tergite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the tergite are generated and organized. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007491 name: sternite morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the sternite are generated and organized. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007493 name: endodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. synonym: "endoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, UBERON:0001045] is_a: GO:0048565 ! digestive tract development [Term] id: GO:0007495 name: visceral mesoderm-endoderm interaction involved in midgut development namespace: biological_process def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] synonym: "visceral mesoderm/endoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007496 name: anterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007497 name: posterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007499 name: ectoderm and mesoderm interaction namespace: biological_process def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] synonym: "ectoderm/mesoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007500 name: mesodermal cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. synonym: "mesoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007501 name: mesodermal cell fate specification namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. synonym: "mesoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007502 name: digestive tract mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007498 ! mesoderm development relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007503 name: fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] is_a: GO:0048513 ! animal organ development is_a: GO:0060612 ! adipose tissue development [Term] id: GO:0007504 name: larval fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007505 name: adult fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0007498 ! mesoderm development is_a: GO:0048608 ! reproductive structure development is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, UBERON:0000948] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! animal organ development relationship: part_of GO:0072359 ! circulatory system development [Term] id: GO:0007508 name: larval heart development namespace: biological_process def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238] is_a: GO:0007507 ! heart development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007509 name: mesoderm migration involved in gastrulation namespace: biological_process def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete, GOC:sat] is_a: GO:0008078 ! mesodermal cell migration is_a: GO:0042074 ! cell migration involved in gastrulation is_a: GO:0090130 ! tissue migration relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0007510 name: cardioblast cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0007512 name: adult heart development namespace: biological_process def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] synonym: "adult cardiac development" RELATED [] is_a: GO:0007507 ! heart development [Term] id: GO:0007515 name: obsolete lymph gland development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid] comment: This term was made obsolete because it was wrongly defined. synonym: "lymph gland development" EXACT [] is_obsolete: true consider: GO:0048535 consider: GO:0048542 [Term] id: GO:0007516 name: hemocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0042386 ! hemocyte differentiation [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732] is_a: GO:0048513 ! animal organ development is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007518 name: myoblast fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048625 ! myoblast fate commitment [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process alt_id: GO:0048637 def: "The developmental sequence of events leading to the formation of adult skeletal muscle tissue. The main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0007520 name: myoblast fusion namespace: biological_process def: "A process in which non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0007521 name: muscle cell fate determination namespace: biological_process def: "The cell fate determination process in which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0007522 name: visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development [Term] id: GO:0007523 name: larval visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007524 name: adult visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development [Term] id: GO:0007525 name: somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007526 name: larval somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007527 name: adult somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction." [GOC:mtg_OBO2OWL_2013] synonym: "neuromuscular junction organization" EXACT [] synonym: "neuromuscular junction stability" RELATED [GOC:pr] synonym: "NMJ stability" RELATED [GOC:pr] is_a: GO:0050808 ! synapse organization [Term] id: GO:0007529 name: establishment of synaptic specificity at neuromuscular junction namespace: biological_process def: "The biological process in which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007528 ! neuromuscular junction development [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007531 name: mating type determination namespace: biological_process def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] is_a: GO:0007530 ! sex determination is_a: GO:0045165 ! cell fate commitment [Term] id: GO:0007532 name: regulation of mating-type specific transcription, DNA-templated namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of cellular DNA-templated transcription." [GOC:go_curators, GOC:txnOH] synonym: "mating-type specific transcriptional control" EXACT [] synonym: "regulation of mating-type specific transcription, DNA-dependent" EXACT [GOC:txnOH] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0007531 ! mating type determination [Term] id: GO:0007533 name: mating type switching namespace: biological_process def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] synonym: "mating type switching and recombination" RELATED [] is_a: GO:0007531 ! mating type determination is_a: GO:0022413 ! reproductive process in single-celled organism [Term] id: GO:0007534 name: gene conversion at mating-type locus namespace: biological_process def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] is_a: GO:0006312 ! mitotic recombination is_a: GO:0022414 ! reproductive process is_a: GO:0035822 ! gene conversion relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007535 name: donor selection namespace: biological_process def: "The process that determines which donor locus a cell uses, in preference to another, in mating type switching." [GOC:mah, PMID:9928492] synonym: "donor preference" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007536 name: activation of recombination (HML) namespace: biological_process def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045911 ! positive regulation of DNA recombination [Term] id: GO:0007537 name: inactivation of recombination (HML) namespace: biological_process def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0007538 name: primary sex determination namespace: biological_process def: "The sex determination process that results in the initial specification of sexual status of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007539 name: primary sex determination, soma namespace: biological_process def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018993 ! somatic sex determination [Term] id: GO:0007540 name: sex determination, establishment of X:A ratio namespace: biological_process def: "The developmental process in which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007541 name: sex determination, primary response to X:A ratio namespace: biological_process def: "The developmental process in which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007542 name: primary sex determination, germ-line namespace: biological_process def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007543 name: sex determination, somatic-gonadal interaction namespace: biological_process def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] synonym: "sex determination, somatic/gonadal interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007542 ! primary sex determination, germ-line [Term] id: GO:0007545 name: processes downstream of sex determination signal namespace: biological_process def: "The sex determination processes that take place after the initial transmission of the sexual phenotype to specific information pathways." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007546 name: somatic processes downstream of sex determination signal namespace: biological_process def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal [Term] id: GO:0007547 name: germ-line processes downstream of sex determination signal namespace: biological_process def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! developmental process involved in reproduction [Term] id: GO:0007549 name: dosage compensation namespace: biological_process def: "Compensating for the variation in the unpaired sex chromosome:autosome chromosome ratios between sexes by activation or inactivation of genes on one or both of the sex chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] xref: Wikipedia:Dosage_compensation is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0007550 name: obsolete establishment of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. synonym: "establishment of dosage compensation" EXACT [] is_obsolete: true consider: GO:0007549 [Term] id: GO:0007551 name: obsolete maintenance of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. synonym: "maintenance of dosage compensation" EXACT [] is_obsolete: true consider: GO:0007549 [Term] id: GO:0007552 name: metamorphosis namespace: biological_process alt_id: GO:0046698 alt_id: GO:0046699 def: "A biological process in which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732, ISBN:0721662544] xref: Wikipedia:Metamorphosis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0007553 name: regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732] synonym: "regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0007554 name: regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "regulation of ecdysteroid anabolism" EXACT [] synonym: "regulation of ecdysteroid biosynthesis" EXACT [] synonym: "regulation of ecdysteroid formation" EXACT [] synonym: "regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0007555 name: regulation of ecdysteroid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell." [GOC:go_curators] is_a: GO:2000831 ! regulation of steroid hormone secretion relationship: regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0007556 name: regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development relationship: regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0007557 name: regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone anabolism" EXACT [] synonym: "regulation of juvenile hormone biosynthesis" EXACT [] synonym: "regulation of juvenile hormone formation" EXACT [] synonym: "regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0007558 name: regulation of juvenile hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0007559 name: obsolete histolysis namespace: biological_process def: "OBSOLETE. The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. xref: Wikipedia:Histolysis is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0007560 name: imaginal disc morphogenesis namespace: biological_process alt_id: GO:0007452 def: "The process in which the anatomical structures derived from an imaginal disc are generated and organized. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] synonym: "imaginal disc metamorphosis" EXACT [] is_a: GO:0048563 ! post-embryonic animal organ morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0007444 ! imaginal disc development relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0007561 name: imaginal disc eversion namespace: biological_process def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007562 name: eclosion namespace: biological_process def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] xref: Wikipedia:Pupa#Emergence is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0007563 name: regulation of eclosion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007562 ! eclosion [Term] id: GO:0007564 name: regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "regulation of cuticle hardening" NARROW [] synonym: "regulation of cuticle tanning" EXACT [] is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0007593 ! chitin-based cuticle sclerotization [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] subset: goslim_chembl synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] synonym: "blastocyst implantation" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007275 ! multicellular organism development relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0007567 name: parturition namespace: biological_process def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732] synonym: "egg laying" NARROW [] synonym: "giving birth" EXACT [] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0044706 ! multi-multicellular organism process [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "A developmental process that is a deterioration and loss of function over time. Aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Aging includes cellular senescence, but is more inclusive. May precede death and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] subset: goslim_chembl subset: goslim_generic synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process [Term] id: GO:0007569 name: cell aging namespace: biological_process def: "An aging process that has as participant a cell after a cell has stopped dividing. Cell aging may occur when a cell has temporarily stopped dividing through cell cycle arrest (GO:0007050) or when a cell has permanently stopped dividing, in which case it is undergoing cellular senescence (GO:0090398). May precede cell death (GO:0008219) and succeed cell maturation (GO:0048469)." [GOC:PO_curators] synonym: "cell ageing" EXACT [] is_a: GO:0007568 ! aging is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0007570 name: obsolete age dependent accumulation of genetic damage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent accumulation of genetic damage" EXACT [] is_obsolete: true consider: GO:0001301 [Term] id: GO:0007571 name: age-dependent general metabolic decline namespace: biological_process def: "A developmental process that arises as the cell progresses toward the end of its lifespan and cause changes cellular metabolism, resulting in a decline in cell function; for example, one aspect of general metabolic decline is a decrease in the efficiency of protein synthesis." [GOC:jh, GOC:mah, PMID:9891807] synonym: "age-dependent decreased translational activity" NARROW [] synonym: "age-dependent increased protein content" NARROW [] synonym: "age-dependent yeast cell size increase" RELATED [] synonym: "nucleolar size increase" NARROW [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007568 ! aging [Term] id: GO:0007572 name: obsolete age dependent decreased translational activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent decreased translational activity" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007573 name: obsolete age dependent increased protein content namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age dependent increased protein content" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007574 name: obsolete cell aging (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. synonym: "cell aging (sensu Saccharomyces)" EXACT [] is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0007575 name: obsolete nucleolar size increase namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. synonym: "nucleolar size increase" EXACT [] is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0007576 name: nucleolar fragmentation namespace: biological_process alt_id: GO:0046616 def: "The cell aging process that results in the nucleolus breaking down into fragments." [GOC:mah, PMID:9271578] synonym: "nucleolar size increase" RELATED [] is_a: GO:0007000 ! nucleolus organization relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0007577 name: obsolete autophagic death (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] comment: This term was made obsolete because a more correct term has been created. synonym: "autophagic death (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0048102 [Term] id: GO:0007578 name: obsolete aging dependent sterility (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. synonym: "aging dependent sterility (sensu Saccharomyces)" EXACT [] is_obsolete: true consider: GO:0030466 [Term] id: GO:0007579 name: obsolete senescence factor accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh] comment: This term was made obsolete because it does not represent a process. synonym: "senescence factor accumulation" EXACT [] is_obsolete: true [Term] id: GO:0007580 name: extrachromosomal circular DNA accumulation involved in cell aging namespace: biological_process def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0007581 name: obsolete age-dependent yeast cell size increase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process. synonym: "age-dependent yeast cell size increase" EXACT [] is_obsolete: true consider: GO:0007571 [Term] id: GO:0007583 name: obsolete killer activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. synonym: "killer activity" EXACT [] is_obsolete: true consider: GO:0042267 [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical [Term] id: GO:0007585 name: respiratory gaseous exchange namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732] subset: goslim_chembl synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or tissue in an animal." [GOC:ai, GOC:dph, GOC:mah, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007590 name: obsolete fat body metabolic process (sensu Insecta) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732] comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. synonym: "fat body metabolic process (sensu Insecta)" EXACT [] is_obsolete: true [Term] id: GO:0007591 name: molting cycle, chitin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0042303 ! molting cycle [Term] id: GO:0007592 name: obsolete protein-based cuticle development namespace: biological_process def: "OBSOLETE. Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "protein-based cuticle anabolism" EXACT [] synonym: "protein-based cuticle biosynthetic process" EXACT [] synonym: "protein-based cuticle development" EXACT [] synonym: "protein-based cuticle formation" EXACT [] synonym: "protein-based cuticle synthesis" EXACT [] is_obsolete: true consider: GO:0040002 consider: GO:0040003 [Term] id: GO:0007593 name: chitin-based cuticle sclerotization namespace: biological_process alt_id: GO:0045452 def: "The process of hardening of a chitin-based cuticle." [GOC:dos, GOC:mtg_sensu] synonym: "chitin-based cuticle tanning" RELATED [GOC:bf, GOC:dos, GOC:sart] synonym: "cuticle hardening" NARROW [] is_a: GO:0007591 ! molting cycle, chitin-based cuticle is_a: GO:0021700 ! developmental maturation is_a: GO:0022404 ! molting cycle process [Term] id: GO:0007594 name: puparial adhesion namespace: biological_process def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] synonym: "puparial glue" RELATED [] is_a: GO:0022609 ! multicellular organism adhesion to substrate relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0007595 name: lactation namespace: biological_process def: "The regulated release of milk from the mammary glands and the period of time that a mother lactates to feed her young." [ISBN:0198506732] synonym: "milk secretion" EXACT [GOC:pr] xref: Wikipedia:Lactation is_a: GO:0007589 ! body fluid secretion relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732] synonym: "blood clotting" EXACT [] xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007597 name: blood coagulation, intrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the interactions among high molecular weight kininogen, prekallikrein, and factor XII that lead to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007598 name: blood coagulation, extrinsic pathway namespace: biological_process def: "A protein activation cascade that contributes to blood coagulation and consists of the self-limited process linking exposure and activation of tissue factor to the activation of clotting factor X." [GOC:add, GOC:mah, GOC:pde] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. is_a: GO:0072376 ! protein activation cascade relationship: part_of GO:0072378 ! blood coagulation, fibrin clot formation [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] xref: Wikipedia:Perception is_a: GO:0050877 ! nervous system process [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007602 name: phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] synonym: "opsin" RELATED [] synonym: "phototransduction, visible light, light adaptation" NARROW [] synonym: "phototrophin mediated phototransduction" NARROW [] xref: Wikipedia:Visual_phototransduction is_a: GO:0007165 ! signal transduction is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0007603 name: phototransduction, visible light namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "visual cascade" EXACT [PMID:1962207, PMID:9822721] synonym: "visual transduction" EXACT [PMID:10611962] is_a: GO:0007602 ! phototransduction is_a: GO:0009584 ! detection of visible light [Term] id: GO:0007604 name: phototransduction, UV namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 400 nanometers." [GOC:go_curators, ISBN:0198506732] synonym: "phototransduction, ultraviolet light" EXACT [] synonym: "phototransduction, ultraviolet radiation" EXACT [] synonym: "phototransduction, UV light" EXACT [] synonym: "phototransduction, UV radiation" EXACT [] synonym: "UV-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction is_a: GO:0009589 ! detection of UV is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007607 name: obsolete taste perception namespace: biological_process def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. synonym: "taste perception" EXACT [] is_obsolete: true consider: GO:0050909 consider: GO:0050912 [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process alt_id: GO:0044708 def: "The internally coordinated responses (actions or inactions) of animals (individuals or groups) to internal or external stimuli, via a mechanism that involves nervous system activity." [GOC:ems, GOC:jl, ISBN:0395448956, PMID:20160973] comment: 1. Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation reviews.\n2. While a broader definition of behavior encompassing plants and single cell organisms would be justified on the basis of some usage (see PMID:20160973 for discussion), GO uses a tight definition that limits behavior to animals and to responses involving the nervous system, excluding plant responses that GO classifies under development, and responses of unicellular organisms that has general classifications for covering the responses of cells in multicellular organisms (e.g. cell chemotaxis). subset: gocheck_do_not_manually_annotate subset: goslim_agr subset: goslim_flybase_ribbon synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] synonym: "single-organism behavior" RELATED [] xref: Wikipedia:Behavior is_a: GO:0008150 ! biological_process [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [GOC:curators, http://www.onelook.com/, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007614 name: short-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Short-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007615 name: anesthesia-resistant memory namespace: biological_process def: "The memory process that results in the formation of consolidated memory resistant to disruption of the patterned activity of the brain, without requiring protein synthesis." [PMID:15143285, PMID:17088531] is_a: GO:0007613 ! memory [Term] id: GO:0007616 name: long-term memory namespace: biological_process def: "The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Long-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [GOC:jl, ISBN:0387520546] is_a: GO:0044703 ! multi-organism reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007619 name: courtship behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] synonym: "courtship behaviour" EXACT [] is_a: GO:0007617 ! mating behavior [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544] is_a: GO:0007618 ! mating [Term] id: GO:0007621 name: negative regulation of female receptivity namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity" EXACT [] synonym: "down-regulation of female receptivity" EXACT [] synonym: "downregulation of female receptivity" EXACT [] synonym: "inhibition of female receptivity" NARROW [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0007622 name: rhythmic behavior namespace: biological_process def: "The specific behavior of an organism that recur with measured regularity." [GOC:jl, GOC:pr] synonym: "rhythmic behavioral response to stimulus" EXACT [] synonym: "rhythmic behaviour" EXACT [] synonym: "rhythmic behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007623 name: circadian rhythm namespace: biological_process alt_id: GO:0050895 def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] synonym: "circadian process" EXACT [] synonym: "circadian response" RELATED [] synonym: "response to circadian rhythm" RELATED [] xref: Wikipedia:Circadian_rhythm is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007624 name: ultradian rhythm namespace: biological_process def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, PMID:19708721] is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007625 name: grooming behavior namespace: biological_process def: "The specific behavior of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl, GOC:pr] synonym: "grooming behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007627 name: obsolete larval behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "larval behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0007628 name: adult walking behavior namespace: biological_process def: "The behavior of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, GOC:pr, ISBN:0198606907] synonym: "adult walking behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior is_a: GO:0090659 ! walking behavior [Term] id: GO:0007629 name: flight behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] synonym: "flight behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007630 name: jump response namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "drinking" NARROW [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The behavior of an organism in response to a visual stimulus." [GOC:jid, GOC:pr] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007633 name: pattern orientation namespace: biological_process def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535] synonym: "behavioral response to pattern orientation" EXACT [] synonym: "behavioural response to pattern orientation" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007634 name: optokinetic behavior namespace: biological_process def: "The behavior of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, GOC:pr, http://www.mercksource.com] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0007636 name: chemosensory jump behavior namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid] synonym: "chemosensory jump behaviour" EXACT [] synonym: "jump response to chemical stimulus" EXACT [] is_a: GO:0007630 ! jump response is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0007637 name: proboscis extension reflex namespace: biological_process def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid] synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT [] synonym: "proboscis extension in response to sugar stimulus" EXACT [] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0051780 ! behavioral response to nutrient is_a: GO:0060004 ! reflex [Term] id: GO:0007638 name: mechanosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] synonym: "behavioral response to mechanical stimulus" EXACT [] synonym: "behavioural response to mechanical stimulus" EXACT [] synonym: "mechanosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior relationship: part_of GO:0009612 ! response to mechanical stimulus [Term] id: GO:0007639 name: homeostasis of number of meristem cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state number of cells within a population of cells in the meristem." [GOC:isa_complete] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0008001 name: obsolete fibrinogen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not describe an activity. synonym: "fibrinogen" EXACT [] is_obsolete: true replaced_by: GO:0005577 [Term] id: GO:0008002 name: obsolete lamina lucida namespace: cellular_component def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] comment: This term was made obsolete because it is thought to be an experimental artefact. xref: Wikipedia:Lamina_lucida is_obsolete: true [Term] id: GO:0008004 name: obsolete lamina reticularis namespace: cellular_component def: "OBSOLETE A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] comment: This term was obsoleted because as a layer of the basement membrane, the lamina reticularis is thought to be an artefact. See PMID:24137544 and PMID:8061357. is_obsolete: true replaced_by: GO:0005604 [Term] id: GO:0008008 name: obsolete membrane attack complex protein beta2 chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "membrane attack complex protein beta2 chain" EXACT [] is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, http://www.copewithcytokines.de/cope.cgi?key=Cytokines, PMID:12183377] comment: See also the molecular function terms 'cytokine activity ; GO:0005125' and 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl is_a: GO:0005125 ! cytokine activity is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0008010 name: structural constituent of chitin-based larval cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of larval cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008011 name: structural constituent of pupal chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of pupal cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008012 name: structural constituent of adult chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of adult cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008013 name: beta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0008014 name: obsolete calcium-dependent cell adhesion molecule activity namespace: molecular_function alt_id: GO:0001538 def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "cadherin" NARROW [] synonym: "calcium-dependent cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0016021 consider: GO:0016339 [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process in which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:1903522 ! regulation of blood circulation relationship: regulates GO:0060047 ! heart contraction [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0008018 name: obsolete structural protein of chorion (sensu Drosophila) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the function is covered by a parent term. synonym: "structural protein of chorion (sensu Drosophila)" EXACT [] is_obsolete: true replaced_by: GO:0005213 [Term] id: GO:0008019 name: obsolete macrophage receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its name is ambiguous, and it was never defined. synonym: "macrophage receptor activity" EXACT [] is_obsolete: true consider: GO:0005044 consider: GO:0008329 [Term] id: GO:0008020 name: G protein-coupled photoreceptor activity namespace: molecular_function alt_id: GO:0004975 def: "Combining with incidental electromagnetic radiation, particularly visible light, and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph, ISBN:0198506732] synonym: "G protein coupled photoreceptor activity" EXACT [] synonym: "G-protein coupled photoreceptor activity" EXACT [] synonym: "photoreceptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0008021 name: synaptic vesicle namespace: cellular_component def: "A secretory organelle, typically 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709, PMID:12563290] comment: This term should not be confused with GO:0097547 'synaptic vesicle protein transport vesicle'. STVs and synaptic vesicles differ both functionally and morphologically. Functionally, STVs are transport vesicles that deliver synaptic vesicle proteins to synapses, while synaptic vesicles are responsible for transmitter release at synapses. Morphologically, synaptic vesicles are very homogeneous, while STVs are very heterogeneous in size and shape. STVs might be a precursor for synaptic vesicles. subset: goslim_synapse synonym: "docked vesicle" NARROW [NIF_Subcellular:sao403156667] xref: NIF_Subcellular:sao1071221672 xref: Wikipedia:Synaptic_vesicle is_a: GO:0044456 ! synapse part is_a: GO:0070382 ! exocytic vesicle is_a: GO:0097458 ! neuron part relationship: part_of GO:0098793 ! presynapse [Term] id: GO:0008022 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxyl function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732] subset: goslim_chembl synonym: "C-terminal binding" EXACT [] synonym: "C-terminal end binding" EXACT [GOC:sl] synonym: "carboxy-terminal binding" RELATED [GOC:jsg] synonym: "carboxy-terminus binding" RELATED [GOC:sl] synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] synonym: "carboxyl-terminus binding" RELATED [GOC:sl] synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] synonym: "COOH-terminal binding" NARROW [GOC:jsg] synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] is_a: GO:0005515 ! protein binding [Term] id: GO:0008023 name: transcription elongation factor complex namespace: cellular_component def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0008024 name: cyclin/CDK positive transcription elongation factor complex namespace: cellular_component def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains a cyclin and a cyclin-dependent protein kinase catalytic subunit." [GOC:bhm, GOC:vw, PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "positive transcription elongation factor complex b" RELATED [] is_a: GO:0008023 ! transcription elongation factor complex is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex [Term] id: GO:0008025 name: obsolete diazepam binding inhibitor activity namespace: molecular_function def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732, PMID:11883709] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "DBI" EXACT [] synonym: "diazepam binding inhibitor activity" EXACT [] synonym: "diazepam-binding inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004857 consider: GO:0030156 consider: GO:0050796 consider: GO:0050809 consider: GO:0050810 consider: GO:0050811 consider: GO:0050812 [Term] id: GO:0008026 name: ATP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] xref: reactome:R-HSA-5686410 "BLM mediates dissolution of double Holliday junction" is_a: GO:0004386 ! helicase activity is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0008505 def: "Enables the transfer of monocarboxylic acids from one side of a membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: reactome:R-HSA-429749 "SLC5A8 transports monocarboxylates from extracellular region to cytosol" xref: reactome:R-HSA-433698 "SLC16A1,3,7,8 cotransport monocarboxylates, H+ from extracellular region to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0008029 name: pentraxin receptor activity namespace: molecular_function def: "Combining with a pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). synonym: "pentaxin receptor" EXACT [] is_a: GO:0001847 ! opsonin receptor activity [Term] id: GO:0008030 name: neuronal pentraxin receptor activity namespace: molecular_function def: "Combining with a neuronal pentraxin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:18840757] synonym: "neuronal pentaxin receptor" EXACT [] is_a: GO:0008029 ! pentraxin receptor activity [Term] id: GO:0008031 name: eclosion hormone activity namespace: molecular_function def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008033 name: tRNA processing namespace: biological_process def: "The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] subset: goslim_yeast synonym: "tRNA maturation" EXACT [GOC:vw] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0008034 name: obsolete lipoprotein binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because its text definition and implicit ontology-structure definition disagreed, and as a result the term had been used in annotations with more than one meaning. synonym: "lipoprotein binding" EXACT [] is_obsolete: true consider: GO:0071723 consider: GO:0071813 [Term] id: GO:0008035 name: high-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with high-density lipoprotein particle, a lipoprotein particle with a high density (typically 1.063-1.21 g/ml) and a diameter of 5-10 nm that contains APOAs and may contain APOCs and APOE." [GOC:mah] synonym: "HDL binding" EXACT [GOC:mah] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0008036 name: diuretic hormone receptor activity namespace: molecular_function def: "Combining with a diuretic hormone and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0008037 name: cell recognition namespace: biological_process def: "The process in which a cell in an organism interprets its surroundings." [GOC:go_curators] subset: goslim_pir synonym: "recognition of surroundings by cell" EXACT [GOC:curators] is_a: GO:0009987 ! cellular process [Term] id: GO:0008038 name: neuron recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] synonym: "neuronal cell recognition" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0008039 name: synaptic target recognition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] subset: goslim_synapse synonym: "neuronal targeting" EXACT [] is_a: GO:0008038 ! neuron recognition [Term] id: GO:0008041 name: obsolete storage protein of fat body (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. synonym: "storage protein of fat body (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0008042 name: obsolete iron-sulfur electron transfer carrier namespace: molecular_function def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ferredoxin" NARROW [] synonym: "iron-sulfur electron transfer carrier" EXACT [] synonym: "iron-sulphur electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008043 name: intracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717] is_a: GO:0044424 ! intracellular part is_a: GO:0070288 ! ferritin complex [Term] id: GO:0008044 name: obsolete adult behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "adult behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030534 [Term] id: GO:0008045 name: motor neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [CL:0000100, GOC:pr, ISBN:0878932437] synonym: "motoneuron axon guidance" EXACT [] synonym: "motor axon guidance" EXACT [] synonym: "motor axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0008046 name: axon guidance receptor activity namespace: molecular_function def: "Combining with an extracellular messenger and transmitting the signal from one side of the membrane to the other to results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:signaling, GOC:tb, PMID:15107857, PMID:15339666] synonym: "receptor activity involved in axon guidance" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008047 name: enzyme activator activity namespace: molecular_function alt_id: GO:0010577 def: "Binds to and increases the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] synonym: "metalloenzyme activator activity" NARROW [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0008048 name: calcium sensitive guanylate cyclase activator activity namespace: molecular_function def: "Binds to and increases the activity of guanylate cyclase in response to a change in calcium ion concentration." [GOC:mah] is_a: GO:0030250 ! guanylate cyclase activator activity [Term] id: GO:0008049 name: male courtship behavior namespace: biological_process alt_id: GO:0016542 def: "The behavior of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, GOC:pr] synonym: "male courtship behaviour" EXACT [] is_a: GO:0060179 ! male mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008050 name: female courtship behavior namespace: biological_process def: "The behavior of a female, for the purpose of attracting a sexual partner." [GOC:bf, GOC:pr] synonym: "female courtship behaviour" EXACT [] is_a: GO:0060180 ! female mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008051 name: obsolete farnesyl-diphosphate farnesyl transferase complex namespace: cellular_component def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. synonym: "farnesyl-diphosphate farnesyl transferase complex" EXACT [] is_obsolete: true consider: GO:0004310 [Term] id: GO:0008052 name: sensory organ boundary specification namespace: biological_process def: "The process in which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "sense organ boundary specification" EXACT [GOC:dph] is_a: GO:0010160 ! formation of animal organ boundary relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0048284 ! organelle fusion [Term] id: GO:0008055 name: ocellus pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, PMID:15176085, PMID:18421706] synonym: "ocellus pigment anabolism" EXACT [] synonym: "ocellus pigment biosynthesis" EXACT [] synonym: "ocellus pigment formation" EXACT [] synonym: "ocellus pigment synthesis" EXACT [] is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0008056 name: ocellus development namespace: biological_process def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0007423 ! sensory organ development relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0008057 name: eye pigment granule organization namespace: biological_process alt_id: GO:0008059 alt_id: GO:0045318 alt_id: GO:0048751 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] synonym: "eye pigment granule organisation" EXACT [GOC:mah] synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008058 name: ocellus pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] synonym: "ocellus pigment granule organisation" EXACT [GOC:curators] synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of beta-(1->4)-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0008062 name: eclosion rhythm namespace: biological_process def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0007562 ! eclosion [Term] id: GO:0008063 name: Toll signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:11135568, PMID:19126860] synonym: "Tl signaling pathway" EXACT [] synonym: "Tl signalling pathway" EXACT [] synonym: "Toll signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0008064 name: regulation of actin polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0030832 ! regulation of actin filament length is_a: GO:0110053 ! regulation of actin filament organization relationship: regulates GO:0008154 ! actin polymerization or depolymerization [Term] id: GO:0008065 name: establishment of blood-nerve barrier namespace: biological_process def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] synonym: "establishment of blood/nerve barrier" EXACT [] is_a: GO:0001885 ! endothelial cell development relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008067 name: obsolete metabotropic glutamate, GABA-B-like receptor activity namespace: molecular_function alt_id: GO:0001643 alt_id: GO:0001645 def: "OBSOLETE. A G protein-coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class C G protein coupled receptor" BROAD [] synonym: "class C G-protein coupled receptor" BROAD [] synonym: "class C GPCR" BROAD [] synonym: "class C orphan receptor activity" EXACT [] synonym: "metabotropic glutamate, GABA-B-like receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0008068 name: extracellularly glutamate-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glutamate is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. synonym: "extracellular-glutamate-gated chloride channel activity" EXACT [] is_a: GO:0005234 ! extracellularly glutamate-gated ion channel activity is_a: GO:0005254 ! chloride channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0008069 name: dorsal/ventral axis specification, ovarian follicular epithelium namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED [] synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009950 ! dorsal/ventral axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0008070 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008071 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD [] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008073 name: ornithine decarboxylase inhibitor activity namespace: molecular_function def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity [Term] id: GO:0008074 name: guanylate cyclase complex, soluble namespace: cellular_component def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008075 name: obsolete receptor guanylate cyclase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] comment: This term was made obsolete because it represents a class of gene products. synonym: "receptor guanylate cyclase activity" EXACT [] is_obsolete: true consider: GO:0004383 consider: GO:0038023 [Term] id: GO:0008076 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: NIF_Subcellular:sao371494298 is_a: GO:0034705 ! potassium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008077 name: obsolete Hsp70/Hsp90 organizing protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb] comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] synonym: "Hsp70/Hsp90 organizing protein activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:sat, GOC:tb, PMID:25119047] synonym: "mesoderm cell migration" EXACT [] is_a: GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0008079 name: translation termination factor activity namespace: molecular_function def: "Functions in the termination of translation." [GOC:ma] is_a: GO:0008135 ! translation factor activity, RNA binding [Term] id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.5 xref: reactome:R-HSA-2468039 "Acetylation of SMC3 subunit of chromosomal arm associated cohesin by ESCO1 or ESCO2" xref: reactome:R-HSA-2473152 "Acetylation of SMC3 subunit of centromeric chromatin associated cohesin by ESCO1 or ESCO2" xref: reactome:R-HSA-6790987 "NAT10 acetylates cytidine-1337 and cytidine-1842 of 18S rRNA yielding 4-acetylcytidine-1377 and 4-acetylcytidine-1842" is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0004434 alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [EC:3.1.4, GOC:curators] subset: goslim_chembl synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 xref: reactome:R-HSA-5693578 "TDP1 and TDP2 process unligatable DSB ends" is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] comment: Also consider annotating to 'receptor agonist activity ; GO:0048018'. subset: goslim_chembl is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0008084 name: imaginal disc growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an imaginal disc growth factor receptor." [GOC:mah] synonym: "imaginal disc growth factor" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0008085 name: obsolete phototransduction, visible light, light adaptation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous. synonym: "phototransduction, visible light, light adaptation" EXACT [] is_obsolete: true consider: GO:0007602 [Term] id: GO:0008086 name: light-activated voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport] synonym: "light-activated voltage gated calcium channel activity" EXACT [] synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity is_a: GO:0010461 ! light-activated ion channel activity [Term] id: GO:0008087 name: light-activated voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] synonym: "light-activated voltage gated calcium channel complex" EXACT [] synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0005891 ! voltage-gated calcium channel complex [Term] id: GO:0008088 name: axo-dendritic transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in neuron projections." [ISBN:0815316194] subset: goslim_synapse synonym: "axon cargo transport" NARROW [] synonym: "axonal transport" NARROW [] synonym: "axoplasmic transport" NARROW [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! transport along microtubule [Term] id: GO:0008089 name: anterograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "anterograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport [Term] id: GO:0008090 name: retrograde axonal transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] subset: goslim_synapse synonym: "retrograde axon cargo transport" EXACT [] is_a: GO:0098930 ! axonal transport [Term] id: GO:0008091 name: spectrin namespace: cellular_component def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [GOC:curators, ISBN:0815316194] xref: NIF_Subcellular:sao536287099 xref: Wikipedia:Spectrin is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0008093 name: cytoskeletal adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a cytoskeletal protein and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0008094 name: DNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004011 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of single- or double-stranded DNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008096 name: juvenile hormone epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the epoxide in a juvenile hormone to the corresponding diol." [GOC:mah, PMID:8396141] xref: EC:3.3.2 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0008097 name: 5S rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] is_a: GO:0019843 ! rRNA binding [Term] id: GO:0008098 name: 5S rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] is_a: GO:0008097 ! 5S rRNA binding [Term] id: GO:0008100 name: obsolete lipophorin namespace: molecular_function def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "lipophorin" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0008101 name: decapentaplegic signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of decapentaplegic (dpp) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:bf, GOC:sart, PMID:17428827] synonym: "decapentaplegic receptor signaling pathway" RELATED [GOC:bf, GOC:sart, GOC:signaling] synonym: "decapentaplegic receptor signalling pathway" RELATED [] synonym: "dpp receptor signaling pathway" RELATED [] synonym: "dpp receptor signalling pathway" RELATED [] synonym: "dpp signaling pathway" RELATED [GOC:bf] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0008103 name: oocyte microtubule cytoskeleton polarization namespace: biological_process alt_id: GO:0048129 def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007309 ! oocyte axis specification relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization [Term] id: GO:0008104 name: protein localization namespace: biological_process alt_id: GO:0008105 def: "Any process in which a protein is transported to, or maintained in, a specific location." [GOC:ai] synonym: "asymmetric protein localisation" RELATED [GOC:mah] synonym: "asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of asymmetric protein localization" RELATED [] synonym: "establishment and maintenance of protein localization" RELATED [] synonym: "protein localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008106 name: alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] synonym: "alcohol:NADP dehydrogenase activity" EXACT [] synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] synonym: "aldehyde reductase (NADPH2) activity" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0004033 ! aldo-keto reductase (NADP) activity [Term] id: GO:0008107 name: galactoside 2-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] xref: EC:2.4.1.69 xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN xref: RHEA:24431 is_a: GO:0031127 ! alpha-(1,2)-fucosyltransferase activity [Term] id: GO:0008108 name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UDP-D-glucose = alpha-D-glucose 1-phosphate + UDP-D-galactose." [EC:2.7.7.12, RHEA:13989] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] synonym: "uridyltransferase activity" BROAD [EC:2.7.7.12] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] xref: EC:2.7.7.12 xref: KEGG:R00955 xref: MetaCyc:GALACTURIDYLYLTRANS-RXN xref: reactome:R-HSA-70361 "GALT transfers UMP from UDP-Glc to Gal1P to form UDP-Gal" xref: RHEA:13989 is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008109 name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] xref: EC:2.4.1.150 xref: MetaCyc:2.4.1.150-RXN xref: RHEA:17413 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008110 name: L-histidine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + L-histidine = 3-(imidazol-5-yl)pyruvate + L-glutamate." [EC:2.6.1.38, RHEA:16565] synonym: "histidine aminotransferase activity" BROAD [] synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38] synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] xref: EC:2.6.1.38 xref: KEGG:R01161 xref: MetaCyc:HISTTRANSAM-RXN xref: RHEA:16565 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008111 name: alpha-methylacyl-CoA racemase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] xref: EC:5.1.99.4 xref: MetaCyc:5.1.99.4-RXN xref: reactome:R-HSA-192056 "Isomerization of 25(R) THCA-CoA to 25(S) THCA-CoA" xref: reactome:R-HSA-193452 "Isomerization of 25(R) DHCA-CoA to 25(S) DHCA-CoA" xref: reactome:R-HSA-193736 "Isomerization of 3,7,24THCA-CoA to (24R, 25R) 3alpha,7alpha,24-trihydroxy-5beta-cholestanoyl-CoA" xref: reactome:R-HSA-193763 "Isomerization of 25(R) TetraHCA-CoA to (24R, 25R) 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestanoyl-CoA" xref: reactome:R-HSA-389897 "Isomerization of (2R)-pristanoyl-CoA to (2S)-pristanoyl-CoA" xref: RHEA:12657 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0008112 name: nicotinamide N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinamide = 1-methylnicotinamide + S-adenosyl-L-homocysteine." [EC:2.1.1.1, RHEA:23884] synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] xref: EC:2.1.1.1 xref: KEGG:R01269 xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-5359451 "NNMT transfers CH3 from SAM to NAM to form MNA" xref: RHEA:23884 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008113 name: peptide-methionine (S)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0033742 alt_id: GO:0072561 def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin, and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin. Can act on oxidized methionine in peptide linkage with specificity for the S enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.11, GOC:mah, GOC:vw, PMID:11169920] synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "MsrA" RELATED [EC:1.8.4.11] synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] synonym: "peptide-methionine-(S)-S-oxide reductase activity" EXACT [] synonym: "protein-methionine-S-oxide reductase activity" EXACT [] xref: EC:1.8.4 xref: EC:1.8.4.11 xref: MetaCyc:RXN-8668 xref: MetaCyc:RXN-8669 xref: reactome:R-HSA-1222363 "MsrA/B reduces peptide-methionine S/R-sulfoxides" xref: reactome:R-HSA-5676940 "MSRA reduces L-methyl-(S)-S-oxide to L-Methionine" is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0008114 name: phosphogluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] xref: EC:1.1.1.43 xref: MetaCyc:1.1.1.43-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008115 name: sarcosine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sarcosine = formaldehyde + glycine + H(2)O(2)." [EC:1.5.3.1, RHEA:13313] synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] xref: EC:1.5.3.1 xref: KEGG:R00610 xref: MetaCyc:SARCOX-RXN xref: RHEA:13313 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0008116 name: prostaglandin-I synthase activity namespace: molecular_function def: "Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2)." [EC:5.3.99.4, RHEA:23580] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] synonym: "cytochrome P450 CYP8A1" NARROW [] synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] xref: EC:5.3.99.4 xref: KEGG:R02267 xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN xref: reactome:R-HSA-76496 "PTGIS, CYP8A1 isomerise PGH2 to PGI2" xref: RHEA:23580 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0008117 name: sphinganine-1-phosphate aldolase activity namespace: molecular_function alt_id: GO:0016001 def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] xref: EC:4.1.2.27 xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN xref: reactome:R-HSA-428676 "sphingosine 1-phosphate => phosphoethanolamine + hexadec-2-enal" xref: reactome:R-HSA-428681 "sphinganine 1-phosphate => phosphoethanolamine + hexadecanal" xref: RHEA:18593 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008118 name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "SiaT" RELATED [EC:2.4.99.6] xref: EC:2.4.99.6 xref: MetaCyc:2.4.99.6-RXN xref: RHEA:15572 is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0008119 name: thiopurine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "TPMT" RELATED [EC:2.1.1.67] xref: EC:2.1.1.67 xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-158609 "TPMT transfers CH3 from AdoMet to 6MP" is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008120 name: ceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] xref: EC:2.4.1.80 xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN xref: reactome:R-HSA-1638104 "Ceramide glucosyltransferase (UGCG) catalyses the transfer of glucose to ceramide" xref: RHEA:12088 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008121 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] synonym: "coenzyme Q-cytochrome c oxidoreductase activity" EXACT [] synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 activity" EXACT [] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: MetaCyc:1.10.2.2-RXN is_a: GO:0009055 ! electron transfer activity is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0008123 name: cholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17] synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17] synonym: "cytochrome P450 CYP7A1" NARROW [] xref: EC:1.14.13.17 xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN xref: reactome:R-HSA-192051 "CYP7A1 7-hydroxylates CHOL" xref: RHEA:21812 is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008124 name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H(2)O." [EC:4.2.1.96, RHEA:11920] synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4alpha-carbinolamine dehydratase activity" RELATED [] synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] xref: EC:4.2.1.96 xref: KEGG:R04734 xref: MetaCyc:RXN-7908 xref: reactome:R-HSA-71146 "4a-hydroxytetrahydrobiopterin => q-dihydrobiopterin + H2O" xref: RHEA:11920 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008125 name: obsolete pancreatic elastase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] comment: This term was made obsolete because it represents a gene product. synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatic elastase I activity" EXACT [] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] xref: EC:3.4.21.36 xref: MetaCyc:3.4.21.36-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008126 name: acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] synonym: "chloroesterase" NARROW [EC:3.1.1.6] synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: MetaCyc:ACETYLESTERASE-RXN xref: UM-BBD_reactionID:r0170 is_a: GO:0034338 ! short-chain carboxylesterase activity [Term] id: GO:0008127 name: quercetin 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + O(2) + quercetin = 2-(3,4-dihydroxybenzoyloxy)-4,6-dihydroxybenzoate + CO." [EC:1.13.11.24, RHEA:15381] synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] synonym: "quercetinase activity" EXACT [EC:1.13.11.24] xref: EC:1.13.11.24 xref: KEGG:R02156 xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN xref: reactome:R-HSA-8953398 "PIR oxygenates quercetin" xref: RHEA:15381 xref: UM-BBD_reactionID:r0891 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008129 name: obsolete actinidain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] comment: This term was made obsolete because it represents a gene product. synonym: "actinidain activity" EXACT [] synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] xref: EC:3.4.22.14 xref: MetaCyc:3.4.22.14-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008130 name: obsolete neutrophil collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "neutrophil collagenase activity" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] xref: EC:3.4.24.34 xref: MetaCyc:3.4.24.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008131 name: primary amine oxidase activity namespace: molecular_function alt_id: GO:0004041 alt_id: GO:0008122 def: "Catalysis of the reaction: a primary amine + H2O + O2 = an aldehyde + NH3 + hydrogen peroxide." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4, MetaCyc:RXN-9597] synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase activity" BROAD [EC:1.4.3.21] synonym: "primary-amine:oxygen oxidoreductase (deaminating) activity" EXACT systematic_synonym [EC:1.4.3.21] xref: EC:1.4.3.21 xref: KEGG:R01853 xref: MetaCyc:RXN-9597 xref: reactome:R-HSA-141186 "MAOA:FAD oxidatively deaminates of 5HT" xref: reactome:R-HSA-141200 "MAOB:FAD oxidatively deaminates of PEA" xref: reactome:R-HSA-141202 "MAOB:FAD oxidatively deaminates TYR" xref: reactome:R-HSA-374909 "Metabolism of Noradrenaline" xref: reactome:R-HSA-379382 "oxidation of dopamine to 3,4dihydroxyphenylacetic acid (DOPAC)" xref: reactome:R-HSA-379395 "Oxidation of 3-Methoxytyramine to homovanillic acid" xref: reactome:R-HSA-5696146 "AOC2 deaminates TYR" xref: reactome:R-HSA-5696183 "AOC3 deaminates BZAM" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0008132 name: obsolete pancreatic elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008133 name: obsolete collagenase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, a protein required to initiate or regulate transcription." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008135 name: translation factor activity, RNA binding namespace: molecular_function def: "Functions during translation by interacting selectively and non-covalently with RNA during polypeptide synthesis at the ribosome." [GOC:ai, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "translation factor activity, nucleic acid binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0008137 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:1.6.5.3 xref: MetaCyc:NADH-DEHYDROG-A-RXN xref: MetaCyc:RXN0-5330 xref: reactome:R-HSA-163217 "Complex I oxidises NADH to NAD+, reduces CoQ to QH2" xref: RHEA:23152 is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0008138 name: protein tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein serine + H2O = protein serine + phosphate; protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] comment: Note that this term applies only to free amino acids. Consider 'protein serine/threonine phosphatase activity' or 'protein tyrosine/serine/threonine phosphatase activity' if you want to annotate a protein phosphatase. See discussion at https://github.com/geneontology/go-ontology/issues/12183 synonym: "dual-specificity protein phosphatase" BROAD [] xref: reactome:R-HSA-5675373 "Nuclear DUSPs dephosphorylate MAPKs" xref: reactome:R-HSA-5675376 "Cytosolic DUSPs dephosphorylate MAPKs" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008139 name: nuclear localization sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] synonym: "NLS binding" EXACT [] synonym: "nuclear localisation sequence binding" EXACT [GOC:mah] synonym: "nuclear localization signal binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0008140 name: cAMP response element binding protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cAMP response element binding protein (a CREB protein)." [GOC:mah] synonym: "3',5' cAMP response element binding protein binding" EXACT [] synonym: "3',5'-cAMP response element binding protein binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] synonym: "CBP" RELATED [GOC:bf] synonym: "CREB binding" EXACT [] synonym: "cyclic AMP response element binding protein binding" EXACT [] is_a: GO:0140297 ! DNA-binding transcription factor binding [Term] id: GO:0008141 name: obsolete puparial glue (sensu Diptera) namespace: molecular_function def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "puparial glue (sensu Diptera)" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0007594 [Term] id: GO:0008142 name: oxysterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/] is_a: GO:0032934 ! sterol binding [Term] id: GO:0008143 name: poly(A) binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:jl] synonym: "poly(A) binding, within an RNA molecule" EXACT [] synonym: "poly(rA) binding" EXACT [GOC:mah] synonym: "poly-A binding" EXACT [GOC:mah] synonym: "polyadenylate binding" EXACT [GOC:mah] is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0008144 name: drug binding namespace: molecular_function def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0008145 name: phenylalkylamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl] is_a: GO:0008144 ! drug binding is_a: GO:0043176 ! amine binding [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [EC:2.8.2, GOC:curators] subset: goslim_chembl synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: reactome:R-HSA-176588 "lithocholate + PAPS => lithocholate sulfate + PAP" xref: reactome:R-HSA-176604 "taurolithocholate + PAPS => taurolithocholate sulfate + PAP" xref: reactome:R-HSA-176669 "N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP" xref: reactome:R-HSA-2022061 "Dermatan sulfate can be further sulfated on position 2 of iduronate" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008147 name: structural constituent of bone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008148 name: obsolete negative transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "negative transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0032785 [Term] id: GO:0008149 name: obsolete para-aminobenzoic acid (PABA) synthase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. synonym: "para-aminobenzoic acid (PABA) synthase" EXACT [] is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 alt_id: GO:0044699 def: "A biological process represents a specific objective that the organism is genetically programmed to achieve. Biological processes are often described by their outcome or ending state, e.g., the biological process of cell division results in the creation of two daughter cells (a divided cell) from a single parent cell. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence." [GOC:pdt] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. When this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code "no data" (ND), is used to indicate this. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast synonym: "biological process" EXACT [] synonym: "physiological process" EXACT [] synonym: "single organism process" RELATED [] synonym: "single-organism process" RELATED [] xref: Wikipedia:Biological_process [Term] id: GO:0008152 name: metabolic process namespace: biological_process alt_id: GO:0044236 alt_id: GO:0044710 def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] synonym: "multicellular organism metabolic process" NARROW [] synonym: "single-organism metabolic process" RELATED [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0008153 name: para-aminobenzoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732, MetaCyc:PWY-6543, PMID:11377864, PMID:11960743] synonym: "4-aminobenzoic acid biosynthesis" EXACT [] synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] synonym: "p-aminobenzoic acid biosynthesis" EXACT [] synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] synonym: "PABA biosynthesis" EXACT [] synonym: "PABA biosynthetic process" EXACT [] synonym: "para-aminobenzoic acid anabolism" EXACT [] synonym: "para-aminobenzoic acid biosynthesis" EXACT [] synonym: "para-aminobenzoic acid formation" EXACT [] synonym: "para-aminobenzoic acid synthesis" EXACT [] synonym: "vitamin Bx biosynthesis" EXACT [] synonym: "vitamin Bx biosynthetic process" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046482 ! para-aminobenzoic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0008154 name: actin polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0007015 ! actin filament organization [Term] id: GO:0008155 name: obsolete larval behavior (sensu Drosophila) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. synonym: "larval behavior (sensu Drosophila)" EXACT [] is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0008156 name: negative regulation of DNA replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] synonym: "DNA replication inhibitor" RELATED [] synonym: "down regulation of DNA replication" EXACT [] synonym: "down-regulation of DNA replication" EXACT [] synonym: "downregulation of DNA replication" EXACT [] synonym: "inhibition of DNA replication" NARROW [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006260 ! DNA replication [Term] id: GO:0008157 name: protein phosphatase 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0008158 name: hedgehog receptor activity namespace: molecular_function def: "Combining with a member of the hedgehog protein family and transmitting the signal across the membrane to initiate a change in cell activity." [GOC:bf, GOC:go_curators, PMID:9278137] synonym: "patched activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008159 name: obsolete positive transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "positive transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0032786 [Term] id: GO:0008160 name: protein tyrosine phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732] is_a: GO:0072542 ! protein phosphatase activator activity [Term] id: GO:0008161 name: obsolete carbamate resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "carbamate resistance" EXACT [] is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0008162 name: obsolete cyclodiene resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "cyclodiene resistance" EXACT [] is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0008163 name: obsolete DDT resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "DDT resistance" EXACT [] is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0008164 name: obsolete organophosphorus resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "organophosphorus resistance" EXACT [] is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0008165 name: obsolete pyrethroid resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "pyrethroid resistance" EXACT [] is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0008166 name: obsolete viral replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. synonym: "viral replication" EXACT [] is_obsolete: true consider: GO:0019079 [Term] id: GO:0008167 name: obsolete sigma virus replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] synonym: "sigma virus replication" EXACT [] is_obsolete: true replaced_by: GO:0019079 [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: reactome:R-HSA-379387 "methylation of Dopamine to form 3-Methoxytyramine" xref: reactome:R-HSA-379464 "Methylation of 3,4-dihydroxyphenylacetic acid to homovanillic acid" xref: reactome:R-HSA-6800149 "N6AMT1:TRMT112 transfers CH3 group from AdoMet to MMAIII" xref: reactome:R-HSA-71286 "guanidinoacetate + S-adenosylmethionine => creatine + S-adenosylhomocysteine" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0008169 name: C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008170 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008171 name: O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 xref: reactome:R-HSA-5578717 "BCDIN3D dimethylates 5' phosphate of pre-miR-145" xref: reactome:R-HSA-5629203 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 4xMeR-PIWIL1:piRNA:TDRD6:TDRKH" xref: reactome:R-HSA-5629218 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in 6xMeR-PIWIL2:piRNA:TDRD1:TDRD12:DDX4:ASZ:MOV10L1" xref: reactome:R-HSA-5629237 "HENMT1 methylates 2' hydroxyl at 3' end of piRNA in MeR-PIWIL4:piRNA:TDRD9:MAEL:TDRKH" xref: reactome:R-HSA-6790907 "Box C/D snoRNP methylates ribonucleotides in pre-rRNA yielding 2'-O-methylribonucleotides" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008172 name: S-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] xref: EC:2.1.1 xref: reactome:R-HSA-209821 "Methylation of N-acetyl-5-HT to form melatonin" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008173 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). xref: reactome:R-HSA-191784 "snRNA Cap hypermethylation" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0008174 name: mRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008175 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] xref: reactome:R-HSA-6782879 "TYW3 methylates yW-86 yielding yW-72 at nucleotide 37 of tRNA(Phe)" xref: reactome:R-HSA-6782881 "LCMT2 methylates yW-72 yielding yW-58 at nucleotide 37 of tRNA(Phe)" xref: reactome:R-HSA-6782890 "LCMT2 methoxycarbonylates yW-58 yielding yW (wybutosine) at nucleotide 37 of tRNA(Phe)" xref: reactome:R-HSA-6783473 "LCMT2 methoxycarbonylates OHyW-72 yielding OHyW (hydroxywybutosine) at nucleotide 37 of tRNA(Phe)" xref: reactome:R-HSA-6786500 "ALKBH8 methylates 5-carboxymethyluridine-34 in tRNA(Arg) and tRNA(Glu) yielding 5-methoxycarbonylmethyluridine-34" xref: reactome:R-HSA-6786567 "KIAA1456 (TRM9L) methylates 5-carboxymethyluridine in tRNA yielding 5-methoxycarbonylmethyluridine" is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0008176 name: tRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: reactome:R-HSA-6782286 "METTL1:WDR4 methylates guanosine-46 of tRNA(Phe) yielding 7-methylguanosine-46" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0008177 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function alt_id: GO:0019737 def: "Catalysis of the reaction: succinate + ubiquinone = fumarate + ubiquinol." [EC:1.3.5.1, RHEA:13713] synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: KEGG:R02164 xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN xref: reactome:R-HSA-163213 "Transfer of electrons through the succinate dehydrogenase complex" xref: reactome:R-HSA-70994 "Succinate <=> Fumarate (with FAD redox reaction on enzyme)" xref: RHEA:13713 is_a: GO:0000104 ! succinate dehydrogenase activity is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0008179 name: adenylate cyclase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl] synonym: "adenylyl cyclase binding" EXACT [] xref: reactome:R-HSA-170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0008180 name: COP9 signalosome namespace: cellular_component def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] synonym: "COP9 complex" EXACT [GOC:krc] synonym: "CSN" EXACT [] synonym: "signalosome" BROAD [GOC:krc] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0008181 name: obsolete tumor suppressor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. synonym: "tumor suppressor" EXACT [] is_obsolete: true consider: GO:0051726 [Term] id: GO:0008184 name: glycogen phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] xref: MetaCyc:GLYCOPHOSPHORYL-RXN xref: reactome:R-HSA-453339 "poly((1,4)-alpha-glucosyl) glycogenin-2 + n orthophosphate => glycogenin-2 + n D-glucose 1-phosphate [PYGL]" xref: reactome:R-HSA-453358 "poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" xref: reactome:R-HSA-71515 "glycogen-glycogenin-1 + n orthophosphate => limit dextrin-glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]" xref: reactome:R-HSA-71590 "glycogen-glycogenin-2 + n orthophosphate => limit dextrin-glycogenin-2 + n D-glucose 1-phosphate [PYGL]" is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0008186 name: RNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004010 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction requires the presence of RNA, and it drives another reaction." [EC:3.6.1.3, GOC:jl] synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008187 name: poly-pyrimidine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0008189 name: obsolete apoptosis inhibitor activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0043066 [Term] id: GO:0008190 name: eukaryotic initiation factor 4E binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732] synonym: "eIF4E binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0008191 name: metalloendopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] synonym: "metalloprotease inhibitor" NARROW [] synonym: "metalloproteinase inhibitor" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0008192 name: RNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008193 name: tRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0008194 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] xref: reactome:R-HSA-162730 "phosphatidylinositol + UDP-N-acetyl-D-glucosamine -> N-acetylglucosaminyl-PI + UDP" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008195 name: phosphatidate phosphatase activity namespace: molecular_function alt_id: GO:0004606 def: "Catalysis of the reaction: a 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4, GOC:pr] synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "phosphatidate phosphohydrolase activity" EXACT [] synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] xref: EC:3.1.3.4 xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN xref: reactome:R-HSA-1483203 "PA is dephosphorylated to DAG by LPIN" xref: reactome:R-HSA-163688 "Dephosphorylation of pChREBP (Thr 666) by PP2A" xref: reactome:R-HSA-163689 "Dephosphorylation of pChREBP (Ser 196) by PP2A" xref: reactome:R-HSA-163750 "Dephosphorylation of phosphoPFKFB1 by PP2A complex" xref: reactome:R-HSA-164056 "Dephosphorylation of pChREBP (Ser 568) by PP2A" xref: reactome:R-HSA-2029468 "Conversion of PA into DAG by PAP-1" xref: reactome:R-HSA-390329 "Dephosphorylation of AKT by PP2A" xref: reactome:R-HSA-5221130 "LPIN catalyzes conversion of phosphatidic acid to diacylglycerol" xref: reactome:R-HSA-6797630 "LRPP4(LRPP1-3,5) hydrolyse LPA" xref: reactome:R-HSA-75899 "1,2-diacyl-glycerol 3-phosphate + H2O => 1,2-diacyl-glycerol + orthophosphate" xref: RHEA:27429 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008196 name: vitellogenin receptor activity namespace: molecular_function def: "Receiving vitellogenin, and delivering vitellogenin into the cell via endocytosis." [GOC:bf, PMID:12429745] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0008197 name: obsolete yolk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "yolk protein" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0045735 [Term] id: GO:0008198 name: ferrous iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai] is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008199 name: ferric iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008200 name: ion channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] is_a: GO:0016248 ! channel inhibitor activity is_a: GO:0099106 ! ion channel regulator activity [Term] id: GO:0008201 name: heparin binding namespace: molecular_function def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732] synonym: "heparan sulfate binding" RELATED [] is_a: GO:0005539 ! glycosaminoglycan binding is_a: GO:0043168 ! anion binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] synonym: "steroid metabolism" EXACT [] xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0008203 name: cholesterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732] synonym: "cholesterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008204 name: ergosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732] synonym: "ergosterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008205 name: ecdysone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732] synonym: "ecdysone metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0045455 ! ecdysteroid metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0008207 name: C21-steroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008208 name: C21-steroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone breakdown" EXACT [] synonym: "C21-steroid hormone catabolism" EXACT [] synonym: "C21-steroid hormone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0008209 name: androgen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732] synonym: "androgen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008210 name: estrogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732] synonym: "estrogen metabolism" EXACT [] synonym: "oestrogen metabolic process" EXACT [] synonym: "oestrogen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008211 name: glucocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732] synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0008212 name: mineralocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732] synonym: "mineralocorticoid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008213 name: protein alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: goslim_yeast synonym: "protein amino acid alkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0008214 name: protein dealkylation namespace: biological_process def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai] synonym: "protein amino acid dealkylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0008215 name: spermine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [CHEBI:15746, GOC:curators] synonym: "spermine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0008216 name: spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] synonym: "spermidine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Bioluminescence is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "Any biological process that results in permanent cessation of all vital functions of a cell. A cell should be considered dead when any one of the following molecular or morphological criteria is met: (1) the cell has lost the integrity of its plasma membrane; (2) the cell, including its nucleus, has undergone complete fragmentation into discrete bodies (frequently referred to as apoptotic bodies). The cell corpse (or its fragments) may be engulfed by an adjacent cell in vivo, but engulfment of whole cells should not be considered a strict criteria to define cell death as, under some circumstances, live engulfed cells can be released from phagosomes (see PMID:18045538)." [GOC:mah, GOC:mtg_apoptosis, PMID:25236395] comment: This term should not be used for direct annotation. The only exception should be when experimental data (e.g., staining with trypan blue or propidium iodide) show that cell death has occurred, but fail to provide details on death modality (accidental versus programmed). When information is provided on the cell death mechanism, annotations should be made to the appropriate descendant of 'cell death' (such as, but not limited to, GO:0097300 'programmed necrotic cell death' or GO:0006915 'apoptotic process'). Also, if experimental data suggest that a gene product influences cell death indirectly, rather than being involved in the death process directly, consider annotating to a 'regulation' term. subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant synonym: "accidental cell death" RELATED [] synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0008220 name: obsolete necrosis namespace: biological_process def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. synonym: "necrosis" EXACT [] is_obsolete: true consider: GO:0001906 consider: GO:0008219 consider: GO:0012501 consider: GO:0019835 consider: GO:0070265 [Term] id: GO:0008222 name: obsolete tumor antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "tumor antigen" EXACT [] is_obsolete: true [Term] id: GO:0008224 name: obsolete Gram-positive antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "Gram-positive antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050830 [Term] id: GO:0008225 name: obsolete Gram-negative antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. synonym: "Gram-negative antibacterial peptide activity" EXACT [] is_obsolete: true consider: GO:0050829 [Term] id: GO:0008226 name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0008227 name: G protein-coupled amine receptor activity namespace: molecular_function def: "Combining with an extracellular amine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:dph] synonym: "amine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "biogenic amine receptor" NARROW [] synonym: "G-protein coupled amine receptor activity" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008228 name: opsonization namespace: biological_process def: "The process in which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732, ISBN:068340007X, ISBN:0781735149] xref: Wikipedia:Opsonin is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0008229 name: obsolete opsonin activity namespace: molecular_function def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "opsonin activity" EXACT [] is_obsolete: true consider: GO:0003823 [Term] id: GO:0008230 name: ecdysone receptor holocomplex namespace: cellular_component def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] is_a: GO:0043235 ! receptor complex is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0008231 name: repressor ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] synonym: "repressor ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008232 name: activator ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] synonym: "activator ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" NARROW [] xref: EC:3.4 xref: reactome:R-HSA-205112 "gamma-secretase cleaves p75NTR, releasing NRIF and TRAF6" xref: reactome:R-HSA-3000243 "Unknown protease degrades GIF:Cbl to release Cbl" xref: reactome:R-HSA-3139027 "Maturation of HIV Virion" xref: reactome:R-HSA-376149 "Proteolytic processing of SLIT" xref: reactome:R-HSA-5655483 "USP1 autocleavage" xref: reactome:R-HSA-5684864 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPB" xref: reactome:R-HSA-5685902 "NAPSA, CTSH, PGA3-5 cleave pro-SFTPC" xref: reactome:R-HSA-5693319 "CTRC hydrolyses PRSS1" is_a: GO:0016787 ! hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "cysteine protease activity" NARROW [] synonym: "thiol protease activity" NARROW [] xref: EC:3.4 xref: reactome:R-HSA-2022381 "Cathepsin Z (Cathepsin X) hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: reactome:R-HSA-2467775 "Autocleavage of ESPL1 (Separase)" xref: reactome:R-HSA-2467809 "ESPL1 (Separase) cleaves centromeric cohesin" xref: reactome:R-HSA-5660752 "USP9X deubiquitinates Ub-SNCA" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008235 name: metalloexopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] is_a: GO:0008237 ! metallopeptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008236 name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE, ISBN:0716720094] synonym: "serine protease activity" NARROW [] xref: reactome:R-HSA-1461993 "pro-HD5 is cleaved by trypsin" xref: reactome:R-HSA-2022383 "Chymase hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-8)" xref: reactome:R-HSA-3132753 "Pancreatic proteases degrade TCN1:Cbl" xref: reactome:R-HSA-6801766 "Trypsin cleaves REG3A or REG3G to generate REG3A,G(38-175)" is_a: GO:0017171 ! serine hydrolase activity is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008237 name: metallopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] synonym: "metalloprotease activity" NARROW [GOC:mah] synonym: "metalloproteinase activity" NARROW [GOC:mah] xref: reactome:R-HSA-157629 "NOTCH2-ligand complex is cleaved to produce NEXT2" xref: reactome:R-HSA-157632 "Complex of NOTCH1 with its ligand is cleaved to produce NEXT1" xref: reactome:R-HSA-193679 "alpha-secretase cleaves the p75NTR extracellular domain" xref: reactome:R-HSA-2022368 "Neprilysin hydrolyzes Angiotensin-(1-9) to Angiotensin-(1-7)" xref: reactome:R-HSA-2022393 "ANPEP hydrolyzes Angiotensin-(2-8) to Angiotensin-(3-8)" xref: reactome:R-HSA-2022396 "Neprilysin hydrolyzes Angiotensin-(1-10) to Angiotensin-(1-7)" xref: reactome:R-HSA-2022399 "ENPEP hydrolyzes Angiotensin-(1-8) to Angiotensin-(2-8)" xref: reactome:R-HSA-2220944 "ADAM10/17 cleaves ligand-bound NOTCH1 PEST domain mutants to produce NEXT1 PEST domain mutants" xref: reactome:R-HSA-2220976 "NOTCH1 HD+PEST domain mutants are cleaved by ADAM10/17 irrespective of ligand binding" xref: reactome:R-HSA-2666278 "NOTCH1 t(7;9)(NOTCH1:M1580_K2555) is cleaved to produce NEXT1" xref: reactome:R-HSA-2730752 "NOTCH1 HD domain mutants are cleaved to produce NEXT1 irrespective of ligand binding" xref: reactome:R-HSA-3928660 "ADAM10 cleaves EFNAs" xref: reactome:R-HSA-5211340 "Anthrax LF cleaves target cell MAP2K1 (MEK1)" xref: reactome:R-HSA-5211356 "Anthrax LF cleaves target cell MAP2K2 (MEK2)" xref: reactome:R-HSA-5211387 "Anthrax LF cleaves target cell MAP2K7 (MEK7)" xref: reactome:R-HSA-5211391 "Anthrax LF cleaves target cell MAP2K4 (MEK4)" xref: reactome:R-HSA-5211400 "Anthrax LF cleaves target cell MAP2K3 (MEK3)" xref: reactome:R-HSA-5211405 "Anthrax LF cleaves target cell MAP2K6 (MEK6)" xref: reactome:R-HSA-8986181 "PITRM1 proteolyzes mitochondrial targeting peptides (presequences)" xref: reactome:R-HSA-9013284 "NOTCH3-ligand complex is cleaved to produce NEXT3" xref: reactome:R-HSA-9604264 "ADAM10 cleaves NOTCH4" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008238 name: exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/glossary.htm#EXOPEPTIDASE] synonym: "exoprotease activity" NARROW [] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008239 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] is_a: GO:0004177 ! aminopeptidase activity [Term] id: GO:0008240 name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14 xref: MetaCyc:3.4.14.10-RXN xref: MetaCyc:3.4.14.9-RXN is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008241 name: peptidyl-dipeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] xref: EC:3.4.15 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008242 name: omega peptidase activity namespace: molecular_function def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] xref: EC:3.4.19 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008243 name: obsolete plasminogen activator activity namespace: molecular_function alt_id: GO:0004296 alt_id: GO:0004297 def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] comment: This term was made obsolete because it represents a gene product. synonym: "abbokinase activity" EXACT [EC:3.4.21.68] synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "plasminogen activator activity" EXACT [] synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] synonym: "t-PA" RELATED [EC:3.4.21.68] synonym: "t-plasminogen activator activity" NARROW [] synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] synonym: "tPA activity" NARROW [EC:3.4.21.-] synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "u-PA" RELATED [EC:3.4.21.68] synonym: "u-plasminogen activator activity" NARROW [] synonym: "uPA" RELATED [EC:3.4.21.68] synonym: "urinary esterase A" RELATED [EC:3.4.21.68] synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] xref: EC:3.4.21.68 xref: EC:3.4.21.73 xref: MetaCyc:3.4.21.68-RXN xref: MetaCyc:3.4.21.73-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008245 name: obsolete lysosomal membrane hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "lysosomal membrane hydrogen-transporting ATPase" EXACT [] synonym: "V-ATPase" RELATED [] is_obsolete: true consider: GO:0046611 [Term] id: GO:0008246 name: obsolete electron transfer flavoprotein namespace: molecular_function def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein" EXACT [] synonym: "ETF" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008247 name: 1-alkyl-2-acetylglycerophosphocholine esterase complex namespace: cellular_component def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT [] synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0008248 name: obsolete pre-mRNA splicing factor activity namespace: molecular_function def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] comment: This term was made obsolete because it describes a biological process. synonym: "pre-mRNA splicing factor activity" EXACT [] is_obsolete: true consider: GO:0008380 [Term] id: GO:0008250 name: oligosaccharyltransferase complex namespace: cellular_component def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] synonym: "oligosaccharyl transferase complex" EXACT [] synonym: "OST complex" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0008251 name: tRNA-specific adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] synonym: "tRNA-adenosine deaminase activity" EXACT [] xref: reactome:R-HSA-6782311 "ADAT2:ADAT3 (hetADAT) deaminates adenosine-34 in tRNAs" xref: reactome:R-HSA-6782336 "ADAT1 deaminates adenosine-37 in tRNA(Ala)" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0008252 name: nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] synonym: "NSP I" RELATED [EC:3.1.3.31] synonym: "NSP II" RELATED [EC:3.1.3.31] synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: MetaCyc:NUCLEOTIDASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008253 name: 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] synonym: "5' nucleotidase activity" EXACT [] synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] synonym: "5'-AMPase" NARROW [EC:3.1.3.5] synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] synonym: "AMPase" NARROW [EC:3.1.3.5] synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] synonym: "UMPase" NARROW [EC:3.1.3.5] synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] xref: EC:3.1.3.5 xref: MetaCyc:5-NUCLEOTID-RXN xref: reactome:R-HSA-109278 "NT5E:Zn2+ hydrolyses AMP,dAMP,GMP, IMP" xref: reactome:R-HSA-109291 "CMP or TMP or UMP + H2O => cytidine, thymidine, or uridine + orthophosphate [NT5E]" xref: reactome:R-HSA-109380 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C1A)" xref: reactome:R-HSA-109387 "(d)AMP, (d)GMP, or (d)IMP + H2O => (deoxy)adenosine, (deoxy)guanosine, or (deoxy)inosine + orthophosphate (NT5C1A)" xref: reactome:R-HSA-109415 "AMP + H2O => adenosine + orthophosphate [NT5C1B]" xref: reactome:R-HSA-109449 "(d)CMP, TMP, or (d)UMP + H2O => (deoxy)cytidine, thymidine, or (deoxy)uridine + orthophosphate (NT5C3)" xref: reactome:R-HSA-109470 "(d)GMP or (d)IMP + H2O => (d)G or (d)I + orthophosphate (NT5C)" xref: reactome:R-HSA-109480 "TMP, uridine 2', 3', or 5' monophosphates, or deoxyuridine 3' or 5' monophosphates + H2O => thymidine or (deoxy)uridine + orthophosphate [NT5C]" xref: reactome:R-HSA-109514 "TMP, (d)UMP, uridine 2' monophosphate, or uridine 3'-monophosphate + H2O => thymidine, deoxyuridine, or uridine + orthophosphate [NT5M]" xref: reactome:R-HSA-5694126 "NT5C3B hydrolyses 7MGP to 7MG" xref: reactome:R-HSA-74248 "(d)GMP or (d)IMP + H2O => (2'-deoxy)guanosine or (2'-deoxy)inosine + orthophosphate (NT5C2)" xref: reactome:R-HSA-8940070 "NT5E:Zn2+ hydrolyses NAD+" xref: reactome:R-HSA-8940074 "NT5E:Zn2+ hydrolyses NMN" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008254 name: 3'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] synonym: "3' nucleotidase activity" EXACT [] synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: MetaCyc:3-NUCLEOTID-RXN is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008255 name: ecdysis-triggering hormone activity namespace: molecular_function def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008256 name: protein histidine pros-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: MetaCyc:2.7.13.1-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008257 name: protein histidine tele-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: MetaCyc:2.7.13.2-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008258 name: head involution namespace: biological_process def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0008259 name: obsolete transforming growth factor beta ligand binding to type I receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type I receptor" EXACT [] synonym: "TGFbeta ligand binding to type I receptor" EXACT [] synonym: "transforming growth factor beta ligand binding to type I receptor" EXACT [] is_obsolete: true consider: GO:0005025 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0008260 name: 3-oxoacid CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] xref: EC:2.8.3.5 xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN xref: reactome:R-HSA-74177 "OXCT dimers transfer CoA from SUCC-CoA to ACA, forming ACA-CoA" xref: RHEA:25480 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008261 name: allatostatin receptor activity namespace: molecular_function def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0008263 name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0008265 name: Mo-molybdopterin cofactor sulfurase activity namespace: molecular_function def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] synonym: "molybdopterin cofactor sulfurase activity" EXACT [] synonym: "molybdopterin synthase sulfurylase activity" EXACT [] xref: EC:2.8.1.9 xref: reactome:R-HSA-947499 "Exchange of oxygen with sulfur in MoCo" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0008266 name: poly(U) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] synonym: "poly(U) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0008267 name: poly-glutamine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0008268 name: obsolete receptor signaling protein tyrosine kinase signaling protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous and it incorporates process information. synonym: "receptor signaling protein tyrosine kinase signaling protein activity" EXACT [] synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] is_obsolete: true consider: GO:0035556 [Term] id: GO:0008269 name: JAK pathway signal transduction adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together two molecules of the JAK signal transduction pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0008270 name: zinc ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] synonym: "zinc binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0008271 name: secondary active sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the secondary active transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] synonym: "sulfate porter activity" RELATED [] synonym: "sulphate porter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008272 name: sulfate transport namespace: biological_process alt_id: GO:0006870 def: "The directed movement of sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "sulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0008273 name: calcium, potassium:sodium antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: reactome:R-HSA-2514891 "SLC24A1 exchanges 4Na+ for Ca2+, K+" xref: reactome:R-HSA-425678 "SLC24A1-4 exchange extracellular 4Na+ for cytosolic Ca2+, K+" xref: reactome:R-HSA-5626316 "SLC24A5 exchanges cytosolic 4Na+ for Golgi luminal Ca2+, K+" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015368 ! calcium:cation antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0008274 name: gamma-tubulin ring complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] synonym: "gammaTuRC" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex [Term] id: GO:0008275 name: gamma-tubulin small complex namespace: cellular_component def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] synonym: "gammaTuSC" EXACT [] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0008276 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732] is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008277 name: regulation of G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G protein-coupled receptor signaling pathway." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0008278 name: cohesin complex namespace: cellular_component alt_id: GO:0008279 alt_id: GO:0008280 alt_id: GO:0043222 def: "A protein complex that is required for sister chromatid cohesion in eukaryotes. The cohesin complex forms a molecular ring complex, and is composed of structural maintenance of chromosomes (SMC) and kleisin proteins. For example, in yeast, the complex is composed of the SMC proteins Smc1p and Smc3p, and the kleisin protein Scc1p. In vertebrates, the complex is composed of the SMC1 (SMC1A or SMC1B) and SMC3 heterodimer attached via their hinge domains to a kleisin (RAD21, REC8 or RAD21L) which links them, and one STAG protein (STAG1, STAG2 or STAG3)." [GOC:jl, GOC:sp, GOC:vw, PMID:9887095] subset: goslim_pir synonym: "14S cohesin" NARROW [] synonym: "9S cohesin" NARROW [] synonym: "cohesin core heterodimer" RELATED [] synonym: "SMC complex" RELATED [] synonym: "SMC/kleisin ring complex" EXACT [] synonym: "Smc1-Smc3 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0008281 name: sulfonylurea receptor activity namespace: molecular_function def: "Combining with sulfonylurea, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:ai, GOC:signaling] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. synonym: "sulphonylurea receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008282 name: inward rectifying potassium channel namespace: cellular_component def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.x subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SURx subunit stimulates channel activity." [GOC:bhm, PMID:16308567, PMID:16956886] synonym: "ATP-sensitive potassium channel complex" EXACT [] synonym: "inward rectifying K+ channel" EXACT [] synonym: "KCNJ11-SUR complex" RELATED [] synonym: "KCNJ11-SURx complex" RELATED [] synonym: "KCNJ8-SUR complex" RELATED [] synonym: "KCNJ8-SURx complex" RELATED [] synonym: "Kir6-SUR complex" RELATED [] synonym: "Kir6.1-SUR complex" RELATED [] synonym: "Kir6.1-SURx complex" RELATED [] synonym: "Kir6.2-SUR complex" RELATED [] synonym: "Kir6.2-SURx complex" RELATED [] synonym: "Kir6.x complex" RELATED [] synonym: "Kir6.x-SURx complex" RELATED [] is_a: GO:0034705 ! potassium channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008283 name: cell population proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. Also note that this term is intended to be used for the proliferation of cells within a multicellular organism, not for the expansion of a population of single-celled organisms. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir synonym: "cell proliferation" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0008284 name: positive regulation of cell population proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] synonym: "activation of cell proliferation" NARROW [] synonym: "positive regulation of cell proliferation" RELATED [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0008283 ! cell population proliferation [Term] id: GO:0008285 name: negative regulation of cell population proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] synonym: "negative regulation of cell proliferation" RELATED [] is_a: GO:0042127 ! regulation of cell population proliferation is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0008283 ! cell population proliferation [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0032869 ! cellular response to insulin stimulus [Term] id: GO:0008287 name: protein serine/threonine phosphatase complex namespace: cellular_component def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] subset: goslim_pir is_a: GO:0044464 ! cell part is_a: GO:1903293 ! phosphatase complex [Term] id: GO:0008288 name: boss receptor activity namespace: molecular_function def: "Combining with a protein bride of sevenless (boss) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [GOC:jl, GOC:signaling] synonym: "sevenless receptor activity" RELATED [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_agr subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast is_a: GO:0005488 ! binding [Term] id: GO:0008290 name: F-actin capping protein complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1900619 ! acetate ester metabolic process [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:1900620 ! acetate ester biosynthetic process [Term] id: GO:0008293 name: torso signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to torso (a receptor tyrosine kinase) on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:go_curators, PMID:8343949] synonym: "torso signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008294 name: calcium- and calmodulin-responsive adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] xref: reactome:R-HSA-111930 "Adenylate cyclase produces cAMP" xref: reactome:R-HSA-442715 "Calmodulin-activated adenylate cyclases ADCY1 and ADCY8 generate cAMP" is_a: GO:0004016 ! adenylate cyclase activity [Term] id: GO:0008295 name: spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732] synonym: "spermidine anabolism" EXACT [] synonym: "spermidine biosynthesis" EXACT [] synonym: "spermidine formation" EXACT [] synonym: "spermidine synthesis" EXACT [] xref: MetaCyc:BSUBPOLYAMSYN-PWY xref: MetaCyc:POLYAMINSYN3-PWY is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0008296 name: 3'-5'-exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] xref: reactome:R-HSA-9023943 "MRN:CtIP exonucleolytically hydrolyzes DNA 3' to SPO11 and SPO11:double-strand break dissociates to SPO11:oligonucleotide and resected 5' end" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008297 name: single-stranded DNA exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] synonym: "single-stranded DNA specific exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008298 name: intracellular mRNA localization namespace: biological_process def: "Any process in which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] synonym: "intracellular mRNA localisation" EXACT [GOC:mah] synonym: "intracellular mRNA positioning" NARROW [] synonym: "mRNA localization, intracellular" EXACT [] synonym: "mRNA positioning, intracellular" NARROW [] is_a: GO:0006403 ! RNA localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008300 name: isoprenoid catabolic process namespace: biological_process alt_id: GO:0016097 def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732] synonym: "isoprenoid breakdown" EXACT [] synonym: "isoprenoid catabolism" EXACT [] synonym: "isoprenoid degradation" EXACT [] synonym: "polyisoprenoid breakdown" NARROW [] synonym: "polyisoprenoid catabolic process" NARROW [] synonym: "polyisoprenoid catabolism" NARROW [] synonym: "polyisoprenoid degradation" NARROW [] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0008301 name: DNA binding, bending namespace: molecular_function def: "The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, GOC:vw, PMID:10710711, PMID:19037758] synonym: "DNA bending activity" EXACT [] synonym: "DNA bending involving DNA binding" EXACT [] is_a: GO:0003677 ! DNA binding [Term] id: GO:0008302 name: female germline ring canal formation, actin assembly namespace: biological_process def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] synonym: "nurse cell ring canal formation, actin assembly" NARROW [] synonym: "ovarian ring canal formation, actin assembly" NARROW [] synonym: "ring canal formation, actin assembly" BROAD [] is_a: GO:0007015 ! actin filament organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007301 ! female germline ring canal formation [Term] id: GO:0008303 name: caspase complex namespace: cellular_component def: "A protein complex that is located in the cytosol and contains one or more cysteine-type endopeptidases (also called caspases), which give the complex a peptidase activity with specificity for the hydrolysis of aspartyl bonds. These complexes may be involved e.g. in apoptotic or inflammation processes." [GOC:cna, GOC:mtg_apoptosis] comment: Note that this term was reinstated from obsolete. synonym: "cysteine-type endopeptidase complex" EXACT [GOC:pr] is_a: GO:0044445 ! cytosolic part is_a: GO:1905369 ! endopeptidase complex [Term] id: GO:0008304 name: obsolete eukaryotic translation initiation factor 4 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "eIF-4" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" EXACT [] is_obsolete: true replaced_by: GO:0016281 [Term] id: GO:0008305 name: integrin complex namespace: cellular_component def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] synonym: "laminin receptor protein" RELATED [] is_a: GO:0098636 ! protein complex involved in cell adhesion is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008307 name: structural constituent of muscle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008308 name: voltage-gated anion channel activity namespace: molecular_function alt_id: GO:0022844 def: "Enables the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, GOC:vw, ISBN:0815340729] synonym: "voltage-dependent ion-selective channel activity" RELATED [] synonym: "voltage-gated ion-selective channel activity" RELATED [] xref: reactome:R-HSA-9012374 "VDAC1 transports PYR from cytosol to mitochondrial intermembrane space" is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005253 ! anion channel activity [Term] id: GO:0008309 name: double-stranded DNA exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] synonym: "double-stranded DNA specific exodeoxyribonuclease activity" RELATED [] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008310 name: single-stranded DNA 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah, PMID:22562358] synonym: "single-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" RELATED [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008297 ! single-stranded DNA exodeoxyribonuclease activity [Term] id: GO:0008311 name: double-stranded DNA 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah, PMID:22562358] synonym: "double-stranded DNA specific 3'-5' exodeoxyribonuclease activity" RELATED [] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008309 ! double-stranded DNA exodeoxyribonuclease activity [Term] id: GO:0008312 name: 7S RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] is_a: GO:0003723 ! RNA binding [Term] id: GO:0008313 name: gurken-activated receptor activity namespace: molecular_function def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] synonym: "gurken receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0005006 ! epidermal growth factor-activated receptor activity [Term] id: GO:0008314 name: gurken signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf, PMID:23972992] synonym: "gurken receptor signaling pathway" EXACT [] synonym: "gurken receptor signalling pathway" EXACT [] synonym: "gurken-activated signaling pathway" RELATED [GOC:signaling] synonym: "signaling by Gurken" EXACT [GOC:bf] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0008315 name: G2/MI transition of meiotic cell cycle namespace: biological_process def: "The cell cycle process in which a cell progresses from meiotic G2 phase to M phase of meiosis I." [PMID:15084480] synonym: "meiotic cell cycle G2/MI phase transition" EXACT [] synonym: "meiotic G2/MI phase transition" EXACT [] synonym: "meiotic G2/MI transition" EXACT [] is_a: GO:0044771 ! meiotic cell cycle phase transition is_a: GO:0044839 ! cell cycle G2/M phase transition is_a: GO:0061982 ! meiosis I cell cycle process [Term] id: GO:0008316 name: structural constituent of vitelline membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] is_a: GO:0035804 ! structural constituent of egg coat [Term] id: GO:0008317 name: gurken receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai] synonym: "gurken receptor ligand" NARROW [] is_a: GO:0005154 ! epidermal growth factor receptor binding [Term] id: GO:0008318 name: protein prenyltransferase activity namespace: molecular_function alt_id: GO:0008244 def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] is_a: GO:0004659 ! prenyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008319 name: obsolete prenyl protein specific endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "prenyl protein specific endopeptidase activity" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function alt_id: GO:0015266 def: "Enables the transfer of a protein from one side of a membrane to the other." [GOC:jl] synonym: "protein channel activity" RELATED [] xref: reactome:R-HSA-1268022 "TOMM40 complex translocates proteins from the cytosol to the mitochondrial intermembrane space" xref: reactome:R-HSA-1299475 "TIMM23 PAM translocates proteins from the mitochndrial intermebrane space to the mitochondrial matrix" xref: reactome:R-HSA-5205661 "Pink1 is recruited from the cytoplasm to the mitochondria" xref: reactome:R-HSA-5210943 "PA63:ANTRX2 oligomer transports EF and LF (target cell endosome to cytosol)" xref: reactome:R-HSA-5210947 "PA63:ANTRX1 oligomer transports EF and LF (target cell endosome to cytosol)" xref: reactome:R-HSA-5228406 "TeNT HC transports TeNT LC from target cell endosome membrane into cytosol" xref: reactome:R-HSA-5244404 "BoNT/B HC transports BoNT/B LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5244428 "BoNT/A HC transports BoNT/A LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5244506 "BoNT/E HC transports BoNT/E LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5246514 "BoNT/C HC transports BoNT/C LC from target cell synaptic vesicle membrane to cytosol" xref: reactome:R-HSA-5250616 "BoNT/D HC transports BoNT/D LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5250884 "BoNT/F HC transports BoNT/F LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5250972 "BoNT/G HC transports BoNT/G LC from target cell synaptic vesicle membrane into cytosol" xref: reactome:R-HSA-5336420 "DT fragment B transports DT fragment A from target cell endosome membrane" is_a: GO:0008565 ! protein transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity [Term] id: GO:0008321 name: Ral guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0016220 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Ral GDP-dissociation stimulator activity" EXACT [] xref: reactome:R-HSA-171026 "Guanine nucleotide exchange on RAL" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017160 ! Ral GTPase binding [Term] id: GO:0008322 name: obsolete Pro-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "Pro-X carboxypeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008324 name: cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cation from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0008327 name: methyl-CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] is_a: GO:0000166 ! nucleotide binding is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0008328 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] is_a: GO:0034702 ! ion channel complex is_a: GO:0098878 ! neurotransmitter receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0008329 name: signaling pattern recognition receptor activity namespace: molecular_function def: "Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species, or damage-associated molecular pattern (DAMP), an endogenous molecule released from damaged cells), and transmitting a signal to initiate a change in cell activity." [GOC:ar, PMID:12507420, PMID:12925128, PMID:14523544, Wikipedia:Pattern_recognition_receptor] comment: This term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway. For pattern recognition receptors which do not relay an intracellular signal (e.g. endocytic pattern recognition receptors), consider instead annotating to 'pattern recognition receptor activity ; GO:0038187' and/or the child terms of 'pattern binding ; GO:0001871'. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. synonym: "macrophage receptor activity" RELATED [] synonym: "signaling PRR activity" EXACT [Wikipedia:Pattern_recognition_receptor] is_a: GO:0038187 ! pattern recognition receptor activity [Term] id: GO:0008330 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: protein threonine phosphate + H2O = protein threonine + phosphate; and protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008331 name: high voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a high voltage-gated channel. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] synonym: "high voltage gated calcium channel activity" EXACT [] synonym: "high voltage-dependent calcium channel activity" EXACT [] synonym: "L-type calcium channel" RELATED [] synonym: "N-type calcium channel" RELATED [] synonym: "P-type calcium channel" RELATED [] synonym: "Q-type calcium channel" RELATED [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008332 name: low voltage-gated calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a low voltage-gated channel. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729, PMID:16382099] synonym: "low voltage gated calcium channel activity" EXACT [] synonym: "low voltage-dependent calcium channel activity" EXACT [] synonym: "T-type calcium channel" RELATED [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008333 name: endosome to lysosome transport namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] is_a: GO:0007041 ! lysosomal transport is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0008334 name: histone mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:krc, GOC:mah, PMID:17855393] comment: In higher Eukaryotes, histone mRNAs (stem-loop containing) are non-polyadenylated and thus have a different form of 3'-end regulation to other mRNAs. In lower Eukaryotes, the 3'-ends of histone mRNAs are polyadenylated. synonym: "histone mRNA metabolism" EXACT [] synonym: "stem-loop-containing histone mRNA 3'-end processing" NARROW [GOC:krc, GOC:mah, PMID:17855393] is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0008335 name: female germline ring canal stabilization namespace: biological_process def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] synonym: "nurse cell ring canal stabilization" NARROW [] synonym: "ovarian ring canal stabilization" NARROW [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0031032 ! actomyosin structure organization relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0008336 name: gamma-butyrobetaine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + 4-(trimethylammonio)butanoate + O(2) = carnitine + CO(2) + succinate." [EC:1.14.11.1, RHEA:24028] synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "g-butyrobetaine dioxygenase activity" EXACT [] synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: KEGG:R02397 xref: MetaCyc:1.14.11.1-RXN xref: reactome:R-HSA-71261 "BBOX1:Fe2+ dimer dioxygenates TEABT and 2OG to form CAR and SUCCA" xref: RHEA:24028 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0008337 name: obsolete selectin namespace: molecular_function def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] comment: This term was made obsolete because it describes a class of gene products. synonym: "selectin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0008340 name: determination of adult lifespan namespace: biological_process def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010259 ! multicellular organism aging [Term] id: GO:0008341 name: obsolete response to cocaine (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "response to cocaine (sensu Insecta)" EXACT [] is_obsolete: true consider: GO:0048148 [Term] id: GO:0008342 name: obsolete larval feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. synonym: "larval feeding behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008343 name: adult feeding behavior namespace: biological_process def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "adult feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008344 name: adult locomotory behavior namespace: biological_process def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "adult locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008345 name: larval locomotory behavior namespace: biological_process def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "larval locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0008346 name: larval walking behavior namespace: biological_process def: "The behavior of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators, GOC:pr] synonym: "larval walking behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior is_a: GO:0090659 ! walking behavior [Term] id: GO:0008347 name: glial cell migration namespace: biological_process alt_id: GO:0043359 def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0008348 name: negative regulation of antimicrobial humoral response namespace: biological_process alt_id: GO:0042154 alt_id: GO:0042155 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] synonym: "attenuation of antimicrobial humoral response" EXACT [] synonym: "down regulation of antimicrobial humoral response" EXACT [] synonym: "down-regulation of antimicrobial humoral response" EXACT [] synonym: "downregulation of antimicrobial humoral response" EXACT [] synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0008349 name: MAP kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] synonym: "MAP4K activity" EXACT [PMID:20811974] synonym: "MAPKKKK" EXACT [] xref: EC:2.7.11 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008350 name: obsolete kinetochore motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. synonym: "kinetochore motor activity" EXACT [] is_obsolete: true consider: GO:0000776 consider: GO:0003777 [Term] id: GO:0008351 name: obsolete microtubule severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. synonym: "microtubule severing activity" EXACT [] is_obsolete: true consider: GO:0008017 consider: GO:0051013 [Term] id: GO:0008352 name: katanin complex namespace: cellular_component def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. is_a: GO:0005875 ! microtubule associated complex is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0008353 name: RNA polymerase II CTD heptapeptide repeat kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] synonym: "CTD kinase activity" EXACT [EC:2.7.11.23] synonym: "RNA polymerase II carboxy-terminal domain kinase activity" EXACT [] synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "primordial germ cell migration" RELATED [] is_a: GO:0016477 ! cell migration is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008358 name: maternal determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0008359 name: regulation of bicoid mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] synonym: "regulation of bicoid mRNA localisation" EXACT [GOC:mah] is_a: GO:0060281 ! regulation of oocyte development is_a: GO:1902875 ! regulation of embryonic pattern specification is_a: GO:1903429 ! regulation of cell maturation is_a: GO:1904580 ! regulation of intracellular mRNA localization relationship: regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0008360 name: regulation of cell shape namespace: biological_process alt_id: GO:0045788 alt_id: GO:0045789 def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] synonym: "cell size control" EXACT [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008362 name: chitin-based embryonic cuticle biosynthetic process namespace: biological_process def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] synonym: "embryonic cuticle anabolism" BROAD [] synonym: "embryonic cuticle biosynthetic process" BROAD [] synonym: "embryonic cuticle formation" BROAD [] synonym: "embryonic cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008363 name: larval chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "larval cuticle anabolism" BROAD [] synonym: "larval cuticle biosynthetic process" BROAD [] synonym: "larval cuticle formation" BROAD [] synonym: "larval cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0008364 name: pupal chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "pupal cuticle anabolism" BROAD [] synonym: "pupal cuticle formation" BROAD [] synonym: "pupal cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0008365 name: adult chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "adult chitin-based cuticle anabolism" EXACT [] synonym: "adult chitin-based cuticle biosynthetic process" EXACT [] synonym: "adult chitin-based cuticle formation" EXACT [] synonym: "adult chitin-based cuticle synthesis" EXACT [] synonym: "adult cuticle anabolism" BROAD [] synonym: "adult cuticle biosynthetic process" BROAD [] synonym: "adult cuticle formation" BROAD [] synonym: "adult cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process alt_id: GO:0042553 def: "Any process in which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0008369 name: obsolete molecular function namespace: molecular_function def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008370 name: obsolete cellular component namespace: cellular_component def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008371 name: obsolete biological process namespace: biological_process def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008373 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of sialic acid to an acceptor molecule, typically the terminal portions of the sialylated glycolipids (gangliosides) or to the N- or O-linked sugar chains of glycoproteins." [EC:2.4.99, GOC:cjm, Wikipedia:Sialyltransferase] xref: EC:2.4.99 xref: reactome:R-HSA-981814 "GalNAc alpha-2,6-sialyltransferase II can add a sialic acid to the T antigen at the alpha 6 position" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008374 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 xref: reactome:R-HSA-1482775 "MLCL is acylated to CL by HADH (IM)" xref: reactome:R-HSA-1482781 "MLCL and PC are converted to CL and 1-acyl LPC by TAZ (IM) (Reversible)" xref: reactome:R-HSA-1482850 "MLCL and PE are converted to CL and 1-acyl LPE by TAZ (IM) (Reversible)" xref: reactome:R-HSA-1482861 "MLCL is acylated to CL by LCLAT1 (ER)" xref: reactome:R-HSA-1482867 "DLCL is acylated to MLCL by LCLAT1 (ER)" xref: reactome:R-HSA-162683 "glucosaminyl-PI + fatty acyl-CoA -> glucosaminyl-acyl-PI + CoA-SH" xref: reactome:R-HSA-3238694 "PORCN palmitoleoylates N-glycosyl WNTs" xref: reactome:R-HSA-422017 "Ghrelin O-acyltransferase decanoylates Proghrelin" xref: reactome:R-HSA-422104 "Ghrelin O-acyltransferase octanoylates Proghrelin" xref: reactome:R-HSA-5358343 "HHAT palmitoylates Hh N-terminal fragment" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008375 name: acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732] synonym: "GlcNAc transferase activity" EXACT [] xref: EC:2.4.1 xref: MetaCyc:2.4.1.223-RXN xref: reactome:R-HSA-5694487 "A4GNT transfers GlcNAc to core 2 mucins" xref: reactome:R-HSA-8879117 "POMGNT2 transfers GlcNAc to Man-DAG1" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008376 name: acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732] synonym: "GalNAc transferase activity" EXACT [] xref: EC:2.4.1 xref: reactome:R-HSA-8855954 "B4GALNT2 transfers GalNAc from UDP-GalNAc to Sial-Gal-GlcNAc-Gal to form the Sd(a) antigen on UMOD" xref: reactome:R-HSA-8931648 "B3GALNT2 transfers GalNAc to GlcNAc-Man-DAG1" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008377 name: light-induced release of internally sequestered calcium ion namespace: biological_process def: "The process in which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] synonym: "light-induced release of calcium from internal store" EXACT [] synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0008378 name: galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732] xref: EC:2.4.1 xref: MetaCyc:2.4.1.151-RXN xref: reactome:R-HSA-1964501 "Addition of galactose to Core 6 glycoprotein" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008379 name: thioredoxin peroxidase activity namespace: molecular_function alt_id: GO:0009031 def: "Catalysis of the reaction: thioredoxin + hydrogen peroxide = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1 xref: MetaCyc:RXN0-267 xref: reactome:R-HSA-2161612 "PGH2 is reduced to PGF2a by FAM213B" xref: reactome:R-HSA-3322995 "PRDX3,5 catalyze TXN2 reduced + H2O2 => TXN2 oxidized + 2H2O" xref: reactome:R-HSA-3341343 "PRDX1,2,5 catalyze TXN reduced + H2O2 => TXN oxidized + 2H2O" xref: reactome:R-HSA-3697882 "PRDX5 reduces peroxynitrite to nitrite using TXN" xref: reactome:R-HSA-3697894 "PRDX5 reduces peroxynitrite to nitrite using TXN2" is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0008380 name: RNA splicing namespace: biological_process alt_id: GO:0006395 def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] subset: goslim_yeast synonym: "pre-mRNA splicing factor activity" RELATED [] xref: Wikipedia:RNA_splicing is_a: GO:0006396 ! RNA processing [Term] id: GO:0008381 name: mechanosensitive ion channel activity namespace: molecular_function alt_id: GO:0022833 def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] synonym: "mechanically gated channel activity" EXACT [] synonym: "mechanically-gated channel activity" EXACT [] synonym: "mechanically-gated ion channel activity" EXACT [] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0008384 name: IkappaB kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] synonym: "CHUK" RELATED [EC:2.7.11.10] synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "IKBKA" RELATED [EC:2.7.11.10] synonym: "IKBKB" RELATED [EC:2.7.11.10] synonym: "IKK" RELATED [EC:2.7.11.10] synonym: "IKK-1" RELATED [EC:2.7.11.10] synonym: "IKK-2" RELATED [EC:2.7.11.10] synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "STK12" RELATED [EC:2.7.11.10] synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] synonym: "TBK1" RELATED [EC:2.7.11.10] xref: EC:2.7.11.10 xref: MetaCyc:2.7.11.10-RXN xref: reactome:R-HSA-5684267 "IKBKB phosphorylates NFkB p105 within the NFkB p105:TPL2:ABIN2 complex" xref: reactome:R-HSA-5684275 "IKBKB phosphorylates TPL2 (MAP3K8) at Ser400" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008385 name: IkappaB kinase complex namespace: cellular_component def: "A trimeric protein complex that phosphorylates inhibitory-kappaB (I-kappaB) proteins. The complex is composed of two kinase subunits (alpha and beta) and a regulatory gamma subunit (also called NEMO). In a resting state, NF-kappaB dimers are bound to inhibitory IKB proteins, sequestering NF-kappaB in the cytoplasm. Phosphorylation of I-kappaB targets I-kappaB for ubiquitination and proteasomal degradation, thus releasing the NF-kappaB dimers, which can translocate to the nucleus to bind DNA and regulate transcription." [GOC:bf, GOC:ma, PMID:12055104, PMID:20300203] synonym: "heterotrimeric IKK complex" EXACT [GOC:bf] synonym: "IKK complex" EXACT [] synonym: "trimeric IKK complex" EXACT [PMID:21173796] is_a: GO:0044445 ! cytosolic part is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0008386 name: cholesterol monooxygenase (side-chain-cleaving) activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] synonym: "Cyp11a1" NARROW [] synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] xref: EC:1.14.15.6 xref: MetaCyc:1.14.15.6-RXN xref: reactome:R-HSA-193054 "Oxidation of cholesterol to 22beta-hydroxycholesterol" xref: reactome:R-HSA-193065 "Oxidation of 22beta-hydroxycholesterol to 20alpha,22beta-hydroxycholesterol" xref: reactome:R-HSA-193101 "CYP11A1 cleaves 20a,22b-DHCHOL" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008387 name: steroid 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP2A12" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008388 name: testosterone 15-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2A4" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008389 name: coumarin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] synonym: "cytochrome P450 CYP2A5" NARROW [] xref: reactome:R-HSA-211881 "Coumarin is 7-hydroxylated by CYP2A13" xref: reactome:R-HSA-76453 "Coumarin is 7-hydroxylated by CYP2A6" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008390 name: testosterone 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 16-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2B10" NARROW [] synonym: "cytochrome P450 CYP2B9" NARROW [] synonym: "cytochrome P450 CYP2D10" NARROW [] synonym: "cytochrome P450 CYP2D11" NARROW [] synonym: "cytochrome P450 CYP2D9" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008391 name: arachidonic acid monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into arachidonic acid and the reduction of the other atom of oxygen to water." [GOC:mah] synonym: "cytochrome P450 CYP2B19" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008392 name: arachidonic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2J5" NARROW [] synonym: "cytochrome P450 CYP2J6" NARROW [] xref: reactome:R-HSA-211983 "CYP2J2 oxidises ARA" is_a: GO:0008391 ! arachidonic acid monooxygenase activity [Term] id: GO:0008395 name: steroid hydroxylase activity namespace: molecular_function alt_id: GO:0008394 def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544] synonym: "cytochrome P450 CYP2G1" NARROW [] synonym: "olfactory-specific steroid hydroxylase activity" NARROW [] xref: reactome:R-HSA-191983 "Cholesterol is hydroxylated to 25-hydroxycholesterol" xref: reactome:R-HSA-191999 "CYP27A1 27-hydroxylates 5bCHOL3a,7a,12a-triol" xref: reactome:R-HSA-192042 "5beta-cholestan-3alpha,7alpha,12alpha,27-tetrol is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al" xref: reactome:R-HSA-192054 "3alpha,7alpha,12alpha-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha-trihydroxy-5beta-cholestanoate (THCA)" xref: reactome:R-HSA-192123 "CYP27A1 27-hydroxylates CHOL" xref: reactome:R-HSA-193060 "CYP19A1 hydroxylates ANDST to E1" xref: reactome:R-HSA-193143 "CYP19A1 hydroxylates TEST to EST17b" xref: reactome:R-HSA-193393 "5beta-cholestan-3alpha, 7alpha-diol is hydroxylated to 5beta-cholestan-3alpha, 7alpha, 26-triol" xref: reactome:R-HSA-193460 "3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestanoate (DHCA)" xref: reactome:R-HSA-193497 "5beta-cholestan-3alpha, 7alpha, 26-triol is oxidized to 3alpha, 7alpha-dihydroxy-5beta-cholestan-26-al" xref: reactome:R-HSA-193713 "3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestanoate (TetraHCA)" xref: reactome:R-HSA-193719 "5beta-cholestan-3alpha,7alpha,24(S),27-tetrol is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al" xref: reactome:R-HSA-193737 "3alpha,7alpha,24(S)-trihydroxy-5beta-cholestan-27-al is oxidized to 3alpha,7alpha,24(S)-trihydroxy-5beta-cholestanoate (3,7,24THCA)" xref: reactome:R-HSA-193780 "5beta-cholestan-3alpha,7alpha,12alpha,24(S),27-pentol is oxidized to 3alpha,7alpha,12alpha,24(S)-tetrahydroxy-5beta-cholestan-27-al" xref: reactome:R-HSA-193787 "5beta-cholestan-3alpha,7alpha,12alpha,24(S)-tetrol is hydroxylated to 5beta-cholestan-3alpha,7alpha,12alpha,24(S), 27-pentol" xref: reactome:R-HSA-193792 "CYP27A1 27-hydroxylates 5-CHOL3,7,24(s)-triol" xref: reactome:R-HSA-193965 "CYP11B2 oxidises 18HCORST to ALDO" xref: reactome:R-HSA-193995 "CYP11B2 18-hydroxylates CORST to 18HCORST" is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0008396 name: oxysterol 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] synonym: "cytochrome P450 CYP7B1" NARROW [] xref: reactome:R-HSA-191972 "27-hydroxycholesterol is 7alpha-hydroxylated" xref: reactome:R-HSA-192065 "CYP7B1 7-hydroxylates 25OH-CHOL" xref: reactome:R-HSA-192178 "CYP39A1 7-hydroxylates 24OH-CHOL" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008397 name: sterol 12-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP8B1" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008398 name: sterol 14-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] synonym: "cytochrome P450 CYP51" NARROW [] synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] xref: EC:1.14.13.70 xref: MetaCyc:1.14.13.70-RXN xref: reactome:R-HSA-194678 "CYP51A1 demethylates LNSOL" xref: RHEA:14917 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0008399 name: naphthalene hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of naphthalene to naphthalene 1,2-oxide." [PMID:1742282, PMID:1981702] synonym: "cytochrome P450 CYP2F2" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008401 name: retinoic acid 4-hydroxylase activity namespace: molecular_function def: "Catalysis of the conversion of retinoic acid to 4-hydroxy-retinoic acid." [PMID:19519282] synonym: "cytochrome P450 CYP261" NARROW [] xref: reactome:R-HSA-211874 "CYP2S1 4-hydroxylates atRA" xref: reactome:R-HSA-211923 "CYP26C1 4-hydroxylates 9cRA" xref: reactome:R-HSA-212007 "CYP26A1,B1 4-hydroxylate atRA" xref: reactome:R-HSA-5362525 "CYP26A1,B1,C1 4-hydroxylate atRA" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008403 name: 25-hydroxycholecalciferol-24-hydroxylase activity namespace: molecular_function alt_id: GO:0030344 def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309] synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] synonym: "cytochrome P450 CYP24" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0008404 name: arachidonic acid 14,15-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C29" NARROW [] synonym: "cytochrome P450 CYP2C39" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008405 name: arachidonic acid 11,12-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C38" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732] synonym: "gonadogenesis" EXACT [GOC:cjm] is_a: GO:0048513 ! animal organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0045137 ! development of primary sexual characteristics [Term] id: GO:0008407 name: chaeta morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the chaeta are generated and organized. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:go_curators] synonym: "bristle morphogenesis" NARROW [GOC:bf, GOC:dos] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0022416 ! chaeta development [Term] id: GO:0008408 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] synonym: "3'-5'-exonuclease activity" EXACT [] xref: reactome:R-HSA-3245943 "Viral DNA cleavage by TREX1" is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008409 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] xref: reactome:R-HSA-5358599 "EXO1 interacting with MSH2:MSH6 excises single strand DNA containing a mismatch" xref: reactome:R-HSA-5358619 "EXO1 interacting with MSH2:MSH3 excises DNA strand containing an insertion/deletion loop (IDL)" is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008410 name: CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] xref: EC:2.8.3 xref: reactome:R-HSA-70713 "BCKDH transfers CoA group from CoA-SH to BCAAs" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008411 name: 4-hydroxybutyrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008412 name: 4-hydroxybenzoate octaprenyltransferase activity namespace: molecular_function alt_id: GO:0000043 alt_id: GO:0048043 alt_id: GO:0048044 def: "Catalysis of the reaction: farnesylfarnesylgeranyl diphosphate + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] synonym: "4-HB polyprenyltransferase activity" EXACT [] synonym: "para-hydroxybenzoate transferase activity" EXACT [] synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0008413 name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate = 8-oxo-7,8-dihydroguanosine phosphate + diphosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881] synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT [] synonym: "8-oxo-GTPase activity" EXACT [] xref: EC:3.6.1 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008414 name: CDP-alcohol phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0008417 name: fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008418 name: protein-N-terminal asparagine amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: protein-L-asparagine + H2O = protein-L-aspartate + NH3. This reaction is the deamidation of an N-terminal asparagine residue in a peptide or protein." [PMID:8910481] xref: EC:3.5.1 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008419 name: RNA lariat debranching enzyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of branched RNA structures that contain vicinal 2'-5'- and 3'-5'-phosphodiester bonds at a branch point nucleotide." [PMID:7519612] is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008420 name: RNA polymerase II CTD heptapeptide repeat phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase II) + H2O = (DNA-directed RNA polymerase II) + phosphate." [PMID:22622228] synonym: "CTD phosphatase activity" EXACT [] synonym: "RNA polymerase II carboxy-terminal domain phosphatase activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0008421 name: long-chain fatty-acyl-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: MetaCyc:3.5.1.55-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008422 name: beta-glucosidase activity namespace: molecular_function alt_id: GO:0016983 def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] synonym: "amygdalase activity" NARROW [EC:3.2.1.21] synonym: "amygdalinase" BROAD [EC:3.2.1.21] synonym: "arbutinase activity" EXACT [EC:3.2.1.21] synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "cellobiase activity" NARROW [EC:3.2.1.21] synonym: "cytokine beta-glucosidase activity" NARROW [] synonym: "elaterase activity" NARROW [EC:3.2.1.21] synonym: "emulsin" RELATED [EC:3.2.1.21] synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] synonym: "gentobiase activity" NARROW [EC:3.2.1.21] synonym: "limarase activity" NARROW [EC:3.2.1.21] synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] synonym: "salicilinase activity" NARROW [EC:3.2.1.21] xref: EC:3.2.1.21 xref: MetaCyc:3.2.1.21-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0008423 name: obsolete bleomycin hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] synonym: "bleomycin hydrolase activity" EXACT [] xref: EC:3.4.22.40 xref: MetaCyc:3.4.22.40-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008424 name: glycoprotein 6-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->6)]-N-acetyl-beta-D-glucosaminyl}asparagine + GDP + H(+)." [EC:2.4.1.68, RHEA:12985] synonym: "FucT" RELATED [EC:2.4.1.68] synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1,6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] xref: EC:2.4.1.68 xref: KEGG:R05988 xref: MetaCyc:2.4.1.68-RXN xref: reactome:R-HSA-1028788 "FUT8 transfers fucosyl group from GDP-Fuc to GlcNAc of NGP" xref: RHEA:12985 is_a: GO:0046921 ! alpha-(1->6)-fucosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0008425 name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] xref: EC:2.1.1 is_a: GO:0030580 ! quinone cofactor methyltransferase activity [Term] id: GO:0008426 name: protein kinase C inhibitor activity namespace: molecular_function alt_id: GO:0004863 def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT [] synonym: "PKC inhibitor activity" EXACT [] is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity [Term] id: GO:0008427 name: calcium-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity [Term] id: GO:0008428 name: ribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0008429 name: phosphatidylethanolamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0008430 name: selenium binding namespace: molecular_function def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0008431 name: vitamin E binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [CHEBI:33234, GOC:curators, ISBN:0721662544] synonym: "alpha-tocopherol binding" NARROW [] synonym: "tocopherol binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0008432 name: JUN kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] synonym: "JNK binding" EXACT [GOC:BHF, GOC:ebc] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0008435 name: obsolete anticoagulant activity namespace: molecular_function def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732] comment: This term was made obsolete because it represents a biological process. synonym: "anticoagulant activity" EXACT [] is_obsolete: true replaced_by: GO:0050819 [Term] id: GO:0008436 name: obsolete heterogeneous nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "hnRNP" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0008437 name: thyrotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732] synonym: "thyrotropin releasing hormone activity" EXACT [] synonym: "TRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008438 name: obsolete 1-phosphatidylinositol-5-phosphate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143] comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. synonym: "1-phosphatidylinositol-5-phosphate kinase" EXACT [] is_obsolete: true consider: GO:0016309 [Term] id: GO:0008439 name: obsolete monophenol monooxygenase activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "monophenol monooxygenase activator activity" EXACT [] synonym: "prophenol oxidase activator" RELATED [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008440 name: inositol-1,4,5-trisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4,5-trisphosphate + ATP = 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ADP + 2 H(+)." [EC:2.7.1.127, RHEA:11020] synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol trisphosphate 3-kinase activity" EXACT [] synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] synonym: "IP3K activity" NARROW [EC:2.7.1.127] xref: EC:2.7.1.127 xref: KEGG:R03433 xref: MetaCyc:2.7.1.127-RXN xref: reactome:R-HSA-1855153 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by ITPKA/B/C in the cytosol" xref: reactome:R-HSA-1855233 "I(1,4,5)P3 is phosphorylated to I(1,3,4,5)P4 by IPMK in the nucleus" xref: RHEA:11020 is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0008441 name: 3'(2'),5'-bisphosphate nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "DPNPase activity" EXACT [EC:3.1.3.7] synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] xref: EC:3.1.3.7 xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN xref: reactome:R-HSA-176606 "Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate" xref: reactome:R-HSA-8953499 "IMPAD1 hydrolyses PAP to AMP" xref: RHEA:10040 is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008442 name: 3-hydroxyisobutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] xref: EC:1.1.1.31 xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN xref: reactome:R-HSA-508473 "methylmalonyl semialdehyde + NADH + H+ <=> beta-hydroxyisobutyrate + NAD+" xref: reactome:R-HSA-70885 "beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+" xref: RHEA:17681 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008443 name: phosphofructokinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a phosphofructose substrate molecule." [GOC:jl] is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008444 name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + CDP-diacylglycerol = 3-(3-sn-phosphatidyl)-sn-glycerol 1-phosphate + CMP + H(+)." [EC:2.7.8.5, RHEA:12593] synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] xref: EC:2.7.8.5 xref: KEGG:R01801 xref: MetaCyc:PHOSPHAGLYPSYN-RXN xref: reactome:R-HSA-1482939 "CDP-DAG is converted to PGP by PGS1" xref: RHEA:12593 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0008445 name: D-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide." [EC:1.4.3.1] synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] xref: EC:1.4.3.1 xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN xref: reactome:R-HSA-6810076 "DDO oxidizes D-Asp to OA" xref: RHEA:12512 is_a: GO:0003884 ! D-amino-acid oxidase activity is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008446 name: GDP-mannose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose = GDP-4-dehydro-6-deoxy-alpha-D-mannose + H(2)O." [EC:4.2.1.47, RHEA:23820] synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "Gmd" RELATED [EC:4.2.1.47] synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] xref: EC:4.2.1.47 xref: KEGG:R00888 xref: MetaCyc:GDPMANDEHYDRA-RXN xref: reactome:R-HSA-6787632 "GMDS dehydrates GDP-Man to GDP-DHDMan" xref: RHEA:23820 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008447 name: L-ascorbate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] synonym: "AAO" RELATED [EC:1.10.3.3] synonym: "ascorbase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] xref: EC:1.10.3.3 xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN xref: RHEA:30243 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008448 name: N-acetylglucosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] xref: EC:3.5.1.25 xref: MetaCyc:NAG6PDEACET-RXN xref: reactome:R-HSA-6803789 "AMDHD2 hydrolyses GlcNGc-6-P to GlcN6P and CCA" xref: RHEA:22936 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008449 name: N-acetylglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] xref: EC:3.1.6.14 xref: MetaCyc:3.1.6.14-RXN xref: reactome:R-HSA-1638032 "N-acetylglucosamine 6-sulfatase (GNS) hydrolyses 6-sulfate groups of the N-acetyl-D-glucosamine 6-sulfate units of keratan sulfate" is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0008450 name: obsolete O-sialoglycoprotein endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] comment: This term was made obsolete because it represents a gene product. synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "O-sialoglycoprotein endopeptidase activity" EXACT [] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] xref: EC:3.4.24.57 xref: MetaCyc:3.4.24.57-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008451 name: obsolete X-Pro aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "X-Pro aminopeptidase activity" EXACT [] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] xref: EC:3.4.11.9 xref: MetaCyc:3.4.11.9-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0008452 name: RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah] is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0008453 name: alanine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] synonym: "AGT activity" EXACT [EC:2.6.1.44] synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] xref: EC:2.6.1.44 xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN xref: reactome:R-HSA-389684 "glyoxylate + alanine => glycine + pyruvate [peroxisome]" xref: reactome:R-HSA-904864 "Mitochondrial AGXT2 tetramer transaminates glyoxylate and alanine to glycine and pyruvate" xref: RHEA:24248 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008454 name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "GnTIV activity" EXACT [EC:2.4.1.145] synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] xref: EC:2.4.1.145 xref: MetaCyc:2.4.1.145-RXN xref: reactome:R-HSA-975903 "Addition of GlcNAc to position 4 by N-acetylglucosaminyltransferase (GnT)-IV" is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0008455 name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTII activity" EXACT [EC:2.4.1.143] synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-(1,6) acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-1,6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta(1,2)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1,2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha(1,6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1,6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] xref: EC:2.4.1.143 xref: MetaCyc:2.4.1.143-RXN xref: reactome:R-HSA-975829 "Addition of a GlcNAc on the alpha 1,4 branch by MGAT2" xref: RHEA:12941 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0008456 name: alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: MetaCyc:3.2.1.49-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0008457 name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] xref: EC:2.4.1.163 xref: MetaCyc:2.4.1.163-RXN xref: RHEA:23004 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008458 name: carnitine O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine + octanoyl-CoA = (S)-octanoylcarnitine + CoA." [EC:2.3.1.137, RHEA:17177] synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] xref: EC:2.3.1.137 xref: KEGG:R03779 xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN xref: reactome:R-HSA-390281 "4,8-dimethylnonanoyl-CoA + carnitine => 4,8-dimethylnonanoylcarnitine + CoASH" xref: RHEA:17177 is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity [Term] id: GO:0008459 name: chondroitin 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-sulphotransferase activity" EXACT [] synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] xref: EC:2.8.2.17 xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-2018682 "CHST3,7 transfer SO4(2-) to position 6 of GalNAc on chondroitin chains" xref: RHEA:11108 is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0008460 name: dTDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H(2)O." [EC:4.2.1.46, RHEA:17221] synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] xref: EC:4.2.1.46 xref: KEGG:R06513 xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN xref: RHEA:17221 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008462 name: obsolete endopeptidase Clp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] comment: This term was made obsolete because it represents a gene product. synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] synonym: "Clp protease" NARROW [EC:3.4.21.92] synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Clp activity" EXACT [] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] xref: EC:3.4.21.92 xref: MetaCyc:3.4.21.92-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008463 name: formylmethionine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-methionine + H(2)O = L-methionine + formate." [EC:3.5.1.31, RHEA:17781] synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] xref: EC:3.5.1.31 xref: KEGG:R00653 xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN xref: RHEA:17781 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008464 name: obsolete gamma-glutamyl hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] synonym: "conjugase activity" RELATED [EC:3.4.19.9] synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] synonym: "gamma-glutamyl hydrolase activity" EXACT [] synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0008465 name: glycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] xref: EC:1.1.1.29 xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN xref: RHEA:17905 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008466 name: glycogenin glucosyltransferase activity namespace: molecular_function alt_id: GO:0047210 def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "glycogenin activity" RELATED [EC:2.4.1.186] synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] xref: EC:2.4.1.186 xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN xref: reactome:R-HSA-3322003 "Autoglucosylation of GYG1 complexed with GYS1-b" xref: reactome:R-HSA-3322014 "Autoglucosylation of GYG2 complexed with GYS2-a" xref: reactome:R-HSA-3322019 "Autoglucosylation of GYG2 complexed with GYS2-b" xref: reactome:R-HSA-3322025 "Autoglucosylation of GYG1 complexed with GYS1-a" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008467 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate. The [heparan sulfate]-glucosamine 3-sulfate has a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: MetaCyc:2.8.2.23-RXN xref: reactome:R-HSA-2076383 "HS3ST1 sulfates GlcN at C3 in heparan sulfate" xref: reactome:R-HSA-2076611 "HS3STs sulfate GlcN at C3 in heparan sulfate" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0008469 name: histone-arginine N-methyltransferase activity namespace: molecular_function alt_id: GO:0016276 def: "Catalysis of the reaction: S-adenosyl-L-methionine + (histone)-arginine = S-adenosyl-L-homocysteine + (histone)-N-methyl-arginine." [PMID:8002954] synonym: "histone methyltransferase activity" BROAD [] synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125] synonym: "histone protein methylase I" RELATED [EC:2.1.1.125] synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "protein methylase I activity" BROAD [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125] xref: reactome:R-HSA-5205799 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-9 of histone H3 (H3R8)" xref: reactome:R-HSA-5205861 "COPRS:CCND1:CDK4:PRMT5:pT5-WDR77 methylates arginine-4 of histone H4 (H4R3)" xref: reactome:R-HSA-5216234 "PRMT5:pT5-WDR77 methylates arginine-4 of histone H2A (H2AR3)" xref: reactome:R-HSA-5661117 "CCND1:CDK4:PRMT5:pT5-WDR77 methylates methyl-arginine-9 of histone H3" xref: reactome:R-HSA-8936584 "PRMT6 arginine methylates H3K4me2-Nucleosome at the ITGA2B gene promoter" xref: reactome:R-HSA-8936608 "PRMT6 arginine methylates H3K4me2-Nucleosome at the GP1BA gene promoter" xref: reactome:R-HSA-8937022 "PRMT6 arginine methylates H3K4me2-Nucleosome at the THBS1 gene promoter" xref: reactome:R-HSA-8937113 "PRMT6 arginine methylates H3K4me2-Nucleosome at the MIR27A gene promoter" is_a: GO:0016274 ! protein-arginine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity [Term] id: GO:0008470 name: isovaleryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10] synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] xref: EC:1.3.99.10 xref: MetaCyc:ISOVALERYL-COA-FAD-RXN xref: reactome:R-HSA-70745 "isovaleryl-CoA + FAD => beta-methylcrotonyl-CoA + FADH2" xref: RHEA:12276 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0008471 name: obsolete laccase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] synonym: "benzenediol:oxygen oxidoreductase activity" RELATED [EC:1.10.3.2] synonym: "laccase activity" EXACT [] synonym: "p-diphenol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urushiol oxidase activity" RELATED [EC:1.10.3.2] is_obsolete: true replaced_by: GO:0016682 [Term] id: GO:0008472 name: obsolete metallocarboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] synonym: "metallocarboxypeptidase D activity" EXACT [] xref: EC:3.4.17.22 xref: MetaCyc:3.4.17.22-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0008473 name: ornithine cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = L-proline + NH(4)(+)." [EC:4.3.1.12, RHEA:24368] comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] synonym: "OCD activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] xref: EC:4.3.1.12 xref: KEGG:R00671 xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN xref: RHEA:24368 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] subset: goslim_chembl synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: reactome:R-HSA-203613 "depalmitoylation of eNOS" xref: reactome:R-HSA-5690517 "PPT1 hydrolyses palmitoylated proteins" xref: reactome:R-HSA-8933328 "LYPLA2 hydrolyses PALM-C3,4-GAP43" is_a: GO:0016790 ! thiolester hydrolase activity is_a: GO:0098599 ! palmitoyl hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008475 name: procollagen-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN xref: reactome:R-HSA-1981104 "Procollagen lysyl hydroxylases convert collagen lysines to 5-hydroxylysines" is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] subset: goslim_chembl synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-8954262 "TPST1,2 transfer SO4(2-) from PAPS to PODXL2" is_a: GO:0008146 ! sulfotransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008477 name: purine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] synonym: "purine nucleosidase reaction" EXACT [] synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008478 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: MetaCyc:PYRIDOXKIN-RXN xref: reactome:R-HSA-964958 "2xPDXK:2xZn2+ phosphorylates PXA" xref: reactome:R-HSA-964962 "2xPDKX:2xZn2+ phosphorylates PDX" xref: reactome:R-HSA-964970 "2xPDXK:2xZn2+ phosphorylates PXL" xref: RHEA:10224 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008479 name: queuine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN xref: reactome:R-HSA-6782443 "QTRT1:QTRTD1 exchange guanine for queuosine at guanosine-34 of tRNA(Tyr)" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0008480 name: sarcosine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + H2O + electron-transfer flavoprotein = glycine + formaldehyde + reduced electron-transfer flavoprotein." [EC:1.5.8.3, RHEA:19793] comment: Note that this was EC:1.5.99.1. synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.8.3] synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.8.3] synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.8.3] synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.8.3] xref: EC:1.5.8.3 xref: KEGG:R00611 xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN xref: reactome:R-HSA-6797913 "SARDH:FAD oxidatively demethylates SARC to Gly" xref: RHEA:19793 is_a: GO:0046997 ! oxidoreductase activity, acting on the CH-NH group of donors, flavin as acceptor [Term] id: GO:0008481 name: sphinganine kinase activity namespace: molecular_function alt_id: GO:0001728 def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase activity" RELATED [] xref: EC:2.7.1.91 xref: MetaCyc:SPHINGANINE-KINASE-RXN xref: reactome:R-HSA-428214 "sphinganine (dihydrosphingosine) +ATP => sphinganine 1-phosphate + ADP" xref: RHEA:15465 is_a: GO:0001727 ! lipid kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008482 name: sulfite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + O(2) + sulfite = H(2)O(2) + H(+) + sulfate." [EC:1.8.3.1, RHEA:24600] synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] synonym: "sulphite oxidase activity" EXACT [] xref: EC:1.8.3.1 xref: KEGG:R00533 xref: MetaCyc:PWY-5326 xref: MetaCyc:SULFITE-OXIDASE-RXN xref: reactome:R-HSA-1614544 "Sulfite is oxidized to sulfate" xref: RHEA:24600 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0008483 name: transaminase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732] synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 xref: reactome:R-HSA-1237102 "Transamination of MOB to methionine" is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0008484 name: sulfuric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] synonym: "sulfatase activity" EXACT [] synonym: "sulphuric ester hydrolase activity" EXACT [] xref: EC:3.1.6 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008486 name: diphosphoinositol-polyphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52] synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52] synonym: "DIPP activity" EXACT [EC:3.6.1.52] xref: EC:3.6.1.52 xref: KEGG:R05777 xref: MetaCyc:3.6.1.52-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008487 name: obsolete prenyl-dependent CAAX protease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "prenyl-dependent CAAX protease activity" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008488 name: gamma-glutamyl carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glutamate + reduced vitamin K + CO2 + O2 = peptidyl-gamma-carboxyglutamate + vitamin K epoxide." [PMID:18374194] xref: EC:4.1.1.90 xref: reactome:R-HSA-159752 "GGCX gamma-carboxylates PROS1(25-676) (pro-protein S)" xref: reactome:R-HSA-159761 "GGCX gamma-carboxylates F7(21-466) (pro-factor VII)" xref: reactome:R-HSA-159795 "GGCX gamma-carboxylates 3D-PROC(33-197) (pro-protein C light chain)" xref: reactome:R-HSA-159803 "GGCX gamma-carboxylates 3D-F9(29-461) (pro-factor IX)" xref: reactome:R-HSA-159819 "GGCX gamma-carboxylates 3D-F10(32-179) (pro-factor X light chain)" xref: reactome:R-HSA-159826 "GGCX gamma-carboxylates F2(25-622) (pro-prothrombin)" xref: reactome:R-HSA-163810 "GGCX gamma-carboxylates GAS6(31-691) (pro-GAS6)" xref: reactome:R-HSA-163820 "GGCX gamma-carboxylates PROZ(24-400) (pro-protein Z)" xref: reactome:R-HSA-6807214 "GGCX gamma-carboxylates BGLAP(24-100) (pro-osteocalcin)" xref: RHEA:45140 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008489 name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactose + a glucosylceramide = a lactosylceramide + uridine-5'-diphosphate. The glucosylceramide has sphinganine as the long chain base." [MetaCyc:RXN-10764, PMID:9593693] synonym: "LacCer synthase activity" EXACT [] synonym: "lactosylceramide synthase activity" EXACT [] synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] xref: MetaCyc:RXN-10764 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008490 name: arsenite secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0008491 def: "Enables the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:jl] synonym: "arsenite porter activity" RELATED [] is_a: GO:0015105 ! arsenite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008492 name: obsolete cAMP generating peptide activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product. synonym: "cAMP generating peptide activity" EXACT [] synonym: "cyclic AMP generating peptide activity" EXACT [] is_obsolete: true consider: GO:0004016 consider: GO:0005179 consider: GO:0046058 [Term] id: GO:0008493 name: tetracycline transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tetracycline from one side of a membrane to the other. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators] synonym: "tetracyclin transporter activity" EXACT [] synonym: "tetracycline transporter activity" RELATED [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0008494 name: translation activator activity namespace: molecular_function def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0008495 name: protoheme IX farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protoheme IX + (2E,6E)-farnesyl diphosphate + H2O = heme o + diphosphate." [MetaCyc:HEMEOSYN-RXN] synonym: "haem O synthase activity" EXACT [] synonym: "heme A:farnesyltransferase activity" EXACT [PMID:9177788] synonym: "heme O synthase activity" EXACT [] synonym: "protohaem IX farnesyltransferase activity" EXACT [] xref: EC:2.5.1 xref: MetaCyc:HEMEOSYN-RXN xref: reactome:R-HSA-2995330 "COX10 transforms heme to heme O" xref: RHEA:28070 is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0008496 name: mannan endo-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->6)-alpha-D-mannosidic linkages in unbranched (1->6)-mannans." [EC:3.2.1.101] synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-D-mannosidase activity" EXACT [] synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] xref: EC:3.2.1.101 xref: MetaCyc:3.2.1.101-RXN xref: reactome:R-HSA-6799581 "MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man" is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0008498 name: obsolete phospholipid scrambling namespace: molecular_function def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] comment: This term was made obsolete because it represents a biological process and not a molecular function. synonym: "phospholipid scrambling" EXACT [] is_obsolete: true replaced_by: GO:0017121 [Term] id: GO:0008499 name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] synonym: "beta-1,3-GalTase activity" BROAD [] synonym: "beta3Gal-Ts activity" BROAD [] synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] xref: reactome:R-HSA-914010 "Addition of GlcNAc to the Tn antigen forms a Core 3 glycoprotein" is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0008500 name: obsolete glycine-, glutamate-, thienylcyclohexylpiperidine binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a conglomeration of three terms. synonym: "glycine-, glutamate-, thienylcyclohexylpiperidine binding" EXACT [] is_obsolete: true consider: GO:0016594 consider: GO:0016595 consider: GO:0016596 [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008503 name: benzodiazepine receptor activity namespace: molecular_function def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015201 def: "Enables the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of a membrane to the other." [CHEBI:25375, GOC:mah] xref: reactome:R-HSA-372542 "Loading of dopamine into synaptic veiscles" xref: reactome:R-HSA-379393 "SLC6A3 cotransports DA, Na+ from extracellular region to cytosol" xref: reactome:R-HSA-380586 "loading of Serotonin in synaptic vesicles" xref: reactome:R-HSA-380620 "Reuptake of serotonin from the synapse" xref: reactome:R-HSA-444160 "VMAT1/2 can mediate the transport of biogenic amines" is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0008506 name: sucrose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] synonym: "hydrogen/sucrose transporter activity" BROAD [] synonym: "sucrose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0009669 ! sucrose:cation symporter activity [Term] id: GO:0008507 name: sodium:iodide symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter activity" EXACT [] xref: reactome:R-HSA-429591 "SLC5A5 cotransports Na+ with I- from extracellular region to cytosol" is_a: GO:0015111 ! iodide transmembrane transporter activity is_a: GO:0015373 ! anion:sodium symporter activity [Term] id: GO:0008508 name: bile acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter activity" EXACT [] xref: reactome:R-HSA-194121 "Co-transport (influx) of bile salts and sodium ions by NTCP" xref: reactome:R-HSA-194187 "SLC10A2 transports bile salts and acids and Na+ from extracellular region to cytosol" xref: reactome:R-HSA-433089 "SOAT can transport taurolithocholate-3-sulphate" is_a: GO:0015125 ! bile acid transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0008509 name: anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "anion transporter activity" EXACT [] xref: reactome:R-HSA-166214 "FA anion flip-flops to the opposite surface" is_a: GO:0015075 ! ion transmembrane transporter activity [Term] id: GO:0008510 name: sodium:bicarbonate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] synonym: "sodium/bicarbonate cotransporter activity" BROAD [] synonym: "sodium:bicarbonate cotransporter activity" BROAD [] xref: reactome:R-HSA-425483 "SLC4A5,7,9 cotransport Na+ with 3HCO3-" xref: reactome:R-HSA-8878664 "SLC4A4 cotransports Na+ with 3HCO3-" is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0008511 name: sodium:potassium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter activity" EXACT [] xref: reactome:R-HSA-426086 "SLC12A1,2 cotransports Na+, K+, 2Cl- from extracellular region to cytosol" is_a: GO:0009674 ! potassium:sodium symporter activity is_a: GO:0015378 ! sodium:chloride symporter activity is_a: GO:0015379 ! potassium:chloride symporter activity [Term] id: GO:0008512 name: sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] synonym: "sulfate/hydrogen symporter activity" EXACT [] synonym: "sulfate:hydrogen symporter activity" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008513 name: secondary active organic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015354 def: "Enables the transfer of organic cations from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:curators] synonym: "organic cation porter activity" RELATED [] synonym: "polyspecific organic cation transmembrane transporter activity" NARROW [] xref: reactome:R-HSA-549241 "SLC22A4 cotransports ERGT, Na+ from extracellular region to cytosol" is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] xref: reactome:R-HSA-2142859 "Growing HA is extruded from the cell by ABCC5" is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0008515 name: sucrose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019188 def: "Enables the transfer of sucrose from one side of a membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "sucrose permease (PTS) activity" EXACT [] synonym: "sucrose permease activity" RELATED [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0008516 name: hexose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] is_a: GO:0015149 ! hexose transmembrane transporter activity is_a: GO:0015292 ! uniporter activity [Term] id: GO:0008517 name: folic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of folic acid (pteroylglutamic acid) from one side of a membrane to the other. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transmembrane transporter activity" EXACT [] synonym: "folate transporter activity" EXACT [] synonym: "folic acid transporter activity" RELATED [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: reactome:R-HSA-200646 "Cytosolic folate export across the plasma membrane" xref: reactome:R-HSA-200652 "Extracellular 5-methyltetrahydrofolate import across the plasma membrane" xref: reactome:R-HSA-200680 "Cytosolic tetrahydrofolate import across the inner mitochondrial membrane" xref: reactome:R-HSA-200720 "Mitochondrial tetrahydrofolate export across the inner mitochondrial membrane" xref: reactome:R-HSA-200729 "Extracellular folate import across the plasma membrane" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0008518 name: folate:anion antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Folate derivative (out) + anion (in) = folate derivative (in) + anion (out). The Reduced Folate Carrier (RCF(SLC19A1) acts by an antiport mechanism. RCF carries several folate derivatives: MTX, PMX, ratitrexed, pralatrexate, 5-methyl THF, and 5-formyl THF." [GOC:mtg_transport, PMID:21568705, PMID:24745983, TC:2.A.48] comment: Changed term label see https://github.com/geneontology/go-ontology/issues/15461. synonym: "reduced folate carrier activity" RELATED [] synonym: "reduced folate transmembrane transporter activity" RELATED [] synonym: "reduced folate transporter" RELATED [] xref: TC:2.A.48 is_a: GO:0008517 ! folic acid transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0008519 name: ammonium transmembrane transporter activity namespace: molecular_function alt_id: GO:0051739 def: "Enables the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [GOC:go_curators, ISBN:0198506732] synonym: "ammonia transmembrane transporter activity" EXACT [] xref: reactome:R-HSA-444393 "RhCG mediates ammonium influx into kidney collecting duct cells" xref: reactome:R-HSA-444416 "RHAG transports NH4+ from cytosol to extracellular region (red blood cells)" xref: reactome:R-HSA-444419 "RhBG mediates ammonium effflux out of kidney collecting duct cells" xref: reactome:R-HSA-446277 "RhCG mediates ammonium efflux out of kidney collecting duct cells" xref: reactome:R-HSA-446278 "RhBG mediates ammonium influx into kidney collecting duct cells" xref: RHEA:28747 is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0008520 name: L-ascorbate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015229 ! L-ascorbic acid transmembrane transporter activity [Term] id: GO:0008521 name: acetyl-CoA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetyl-CoA from one side of a membrane to the other. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] synonym: "acetyl-CoA transporter activity" RELATED [] xref: reactome:R-HSA-727759 "SLC33A1 transports Ac-CoA from cytosol to Golgi lumen" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0008523 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] xref: reactome:R-HSA-199206 "SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol" xref: reactome:R-HSA-199219 "SLC5A6 cotransports extracellular Btn and 2xNa+ to cytosol" xref: reactome:R-HSA-429581 "SLC5A6 transports vitamins from extracellular region to cytosol" is_a: GO:0015370 ! solute:sodium symporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0008524 name: glucose 6-phosphate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity relationship: part_of GO:0005355 ! glucose transmembrane transporter activity [Term] id: GO:0008525 name: phosphatidylcholine transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylcholine into, out of or within a cell, or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732] synonym: "phosphatidylcholine transmembrane transporter activity" NARROW [GOC:bf, GOC:vw] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008526 name: phosphatidylinositol transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylinositol into, out of or within a cell, or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732] synonym: "phosphatidylinositol transfer" EXACT [] xref: reactome:R-HSA-8869241 "PITPNM1,2,3 exchange PI for PA" xref: reactome:R-HSA-8874470 "TNFAIP8 proteins transfer PI(4,5)P2, PI(3,4,5)P3 from cytosolic vesicles to plasma membrane" is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008527 name: taste receptor activity namespace: molecular_function def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] synonym: "gustatory receptor" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0008528 name: G protein-coupled peptide receptor activity namespace: molecular_function def: "Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] synonym: "peptide receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0008529 name: obsolete endogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "endogenous peptide receptor activity" EXACT [] is_obsolete: true consider: GO:0001653 consider: GO:0005622 [Term] id: GO:0008530 name: obsolete exogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "exogenous peptide receptor activity" EXACT [] is_obsolete: true consider: GO:0001653 consider: GO:0005576 [Term] id: GO:0008531 name: riboflavin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN + 2 H(+)." [EC:2.7.1.26, RHEA:14357] synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] synonym: "FK" RELATED [EC:2.7.1.26] synonym: "flavokinase activity" EXACT [EC:2.7.1.26] synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] xref: EC:2.7.1.26 xref: KEGG:R00549 xref: MetaCyc:RIBOFLAVINKIN-RXN xref: reactome:R-HSA-196964 "RFK:Mg2+ phosphorylates RIB" xref: RHEA:14357 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008532 name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "GnTE activity" EXACT [EC:2.4.1.149] synonym: "N-acetyllactosamine beta(1,3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta-(1,4)-GlcNAcbeta-r-beta-(1,3)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta-1,4-GlcNAcbeta-beta-1,3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta-1,3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] xref: EC:2.4.1.149 xref: MetaCyc:2.4.1.149-RXN xref: reactome:R-HSA-2025724 "B3GNT1,2,3,4,7 add GlcNAc to form Keratan-PG" xref: RHEA:14389 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008533 name: obsolete astacin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] comment: This term was made obsolete because it represents a gene product. synonym: "astacin activity" EXACT [] synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] xref: EC:3.4.24.21 xref: MetaCyc:3.4.24.21-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008534 name: oxidized purine nucleobase lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0003907 def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] synonym: "bifunctional DNA glycosylase activity" BROAD [] synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "oxidized purine base lesion DNA N-glycosylase activity" EXACT [GOC:curators] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: MetaCyc:3.2.2.23-RXN xref: reactome:R-HSA-110229 "Cleavage of formamidopyrimidine (FapyA) by NTHL1 glycosylase" xref: reactome:R-HSA-110243 "Cleavage of 8-oxoguanine by OGG1 glycosylase" xref: reactome:R-HSA-110244 "Cleavage of formamidopyrimidine (FapyG) by OGG1 glycosylase" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity [Term] id: GO:0008535 name: respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] synonym: "cytochrome c oxidase biogenesis" BROAD [] synonym: "cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0008536 name: Ran GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] synonym: "Ran protein binding" EXACT [] synonym: "Ran-binding protein" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0008537 name: proteasome activator complex namespace: cellular_component def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] synonym: "PA28" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0008538 name: obsolete proteasome activator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PA28" NARROW [] synonym: "proteasome activator activity" EXACT [] is_obsolete: true consider: GO:0061133 consider: GO:0061136 [Term] id: GO:0008539 name: obsolete proteasome inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PI-31" NARROW [] synonym: "proteasome inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004866 consider: GO:0061136 [Term] id: GO:0008540 name: proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008541 name: proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008542 name: visual learning namespace: biological_process def: "Any process in an organism in which a change in behavior of an individual occurs in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] synonym: "spatial learning" RELATED [] is_a: GO:0007632 ! visual behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0008543 name: fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "FGF receptor signaling pathway" EXACT [] synonym: "FGF receptor signalling pathway" EXACT [] synonym: "FGFR signaling pathway" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway relationship: part_of GO:0044344 ! cellular response to fibroblast growth factor stimulus [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of an animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, UBERON:0001003] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development [Term] id: GO:0008545 name: JUN kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] synonym: "JNKK" EXACT [] xref: EC:2.7.11 xref: reactome:R-HSA-168162 "Phosphorylation of human JNKs by activated MKK4/MKK7" is_a: GO:0004708 ! MAP kinase kinase activity [Term] id: GO:0008546 name: obsolete microtubule/chromatin interaction namespace: biological_process def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] comment: This term was made obsolete because it represents a molecular function. synonym: "microtubule/chromatin interaction" EXACT [] is_obsolete: true consider: GO:0003677 consider: GO:0003682 consider: GO:0008017 consider: GO:0030674 [Term] id: GO:0008547 name: obsolete protein-synthesizing GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "protein-synthesizing GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0006412 consider: GO:0008135 [Term] id: GO:0008548 name: obsolete signal-recognition-particle GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "signal-recognition-particle GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0005786 [Term] id: GO:0008549 name: obsolete dynamin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "dynamin GTPase activity" EXACT [] synonym: "dynamine GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006897 [Term] id: GO:0008550 name: obsolete tubulin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "tubulin GTPase activity" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0007021 [Term] id: GO:0008551 name: cadmium-exporting ATPase activity namespace: molecular_function alt_id: GO:0008561 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) -> ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] synonym: "cadmium exporting ATPase activity" EXACT [] synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] xref: EC:3.6.3.3 xref: MetaCyc:3.6.3.3-RXN xref: RHEA:12132 is_a: GO:0015086 ! cadmium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0008552 name: obsolete zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015086 consider: GO:0015087 consider: GO:0015094 consider: GO:0015099 consider: GO:0015662 [Term] id: GO:0008553 name: proton-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of protons from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) -> ADP + phosphate + H+(out). These transporters use a phosphorylative mechanism, which have a phosphorylated intermediate state during the ion transport cycle." [EC:3.6.3.6] synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6] synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6] synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6] synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "hydrogen-exporting ATPase activity, phosphorylative mechanism" RELATED [] synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6] synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6] synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6] synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6] synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6] synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6] xref: EC:3.6.3.6 xref: MetaCyc:3.6.3.6-RXN is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0036442 ! proton-exporting ATPase activity [Term] id: GO:0008554 name: sodium-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) -> ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7] synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7] synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7] synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7] xref: EC:3.6.3.7 xref: MetaCyc:3.6.3.7-RXN xref: RHEA:14633 is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0008555 name: chloride-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] synonym: "chloride ABC transporter" NARROW [] synonym: "chloride transporting ATPase activity" EXACT [] synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: MetaCyc:3.6.3.11-RXN xref: RHEA:24128 is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0008556 name: potassium-transporting ATPase activity namespace: molecular_function alt_id: GO:0015618 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12] synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12] synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-transporting ATPase activity" EXACT [] synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12] synonym: "potassium ABC transporter" NARROW [] synonym: "potassium transporting ATPase activity" EXACT [] synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "potassium-uptake-ATPase activity" EXACT [] xref: EC:3.6.3.12 xref: RHEA:16777 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0008558 name: guanine-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37] synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37] synonym: "guanine ABC transporter" NARROW [] xref: EC:3.6.3.37 xref: MetaCyc:3.6.3.37-RXN xref: RHEA:20832 is_a: GO:0015208 ! guanine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0008559 name: xenobiotic transmembrane transporting ATPase activity namespace: molecular_function alt_id: GO:0005226 alt_id: GO:0008560 def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44] synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44] synonym: "MDR protein" RELATED [EC:3.6.3.44] synonym: "multidrug resistance exporter" RELATED [] synonym: "multidrug-resistance protein" RELATED [] synonym: "P-glycoprotein" RELATED [] synonym: "PDR protein" RELATED [EC:3.6.3.44] synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44] synonym: "steroid ABC transporter" NARROW [] synonym: "steroid-transporting ATPase activity" EXACT [] synonym: "xenobiotic ABC transporter" NARROW [] xref: EC:3.6.3.44 xref: MetaCyc:3.6.3.44-RXN xref: reactome:R-HSA-1467457 "ABCA8,B1,B5 transport xenobiotics from cytosol to extracellular region" xref: reactome:R-HSA-2161506 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" xref: reactome:R-HSA-2161538 "abacavir [cytosol] + ATP + H2O => abacavir[extracellular] + ADP + phosphate" is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0042910 ! xenobiotic transmembrane transporter activity [Term] id: GO:0008563 name: obsolete alpha-factor sex pheromone exporter namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. synonym: "alpha-factor sex pheromone exporter" EXACT [] synonym: "alpha-factor-transporting ATPase" RELATED [] is_obsolete: true [Term] id: GO:0008564 name: protein-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins." [EC:3.6.3.50] synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50] synonym: "protein-secreting ATPase activity" EXACT [] xref: EC:3.6.3.50 xref: MetaCyc:3.6.3.50-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0008565 name: protein transporter activity namespace: molecular_function alt_id: GO:0015463 def: "Enables the directed movement of proteins into, out of or within a cell, or between cells." [ISBN:0198506732] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein carrier activity" EXACT [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] xref: reactome:R-HSA-184269 "Monoubiquitinated N-myristoyl GAG polyprotein is targeted to the late endosomal vesicle membrane by the ESCRT-I complex" xref: reactome:R-HSA-3149434 "Transport of GAG to the Plasma Membrane" xref: reactome:R-HSA-5229111 "AP4 transports APP from trans-Golgi network to endosome lumen" is_a: GO:0005215 ! transporter activity [Term] id: GO:0008566 name: mitochondrial protein-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51] xref: EC:3.6.3.51 xref: MetaCyc:3.6.3.51-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0008567 name: obsolete dynein ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "dynein ATPase activity" EXACT [] is_obsolete: true consider: GO:0003777 consider: GO:0007018 [Term] id: GO:0008568 name: microtubule-severing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] comment: See also the cellular component term 'katanin complex ; GO:0008352'. synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3] synonym: "katanin activity" NARROW [EC:3.6.4.3] xref: EC:3.6.4.3 xref: MetaCyc:3.6.4.3-RXN is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008569 name: ATP-dependent microtubule motor activity, minus-end-directed namespace: molecular_function def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP." [EC:3.6.4.5, GOC:mah, GOC:vw] synonym: "ATP-dependent minus-end-directed microtubule motor activity" EXACT [] synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5] synonym: "minus-end-directed ATP-dependent microtubule motor activity" EXACT [] synonym: "minus-end-directed kinesin ATPase activity" EXACT [] synonym: "minus-end-directed microtubule motor activity" BROAD [] xref: EC:3.6.4.5 xref: MetaCyc:3.6.4.5-RXN is_a: GO:1990939 ! ATP-dependent microtubule motor activity [Term] id: GO:0008570 name: obsolete myosin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "myosin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0000146 consider: GO:0030048 [Term] id: GO:0008571 name: obsolete non-chaperonin molecular chaperone ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] comment: This term was made obsolete because it represents a class of gene products. synonym: "non-chaperonin molecular chaperone ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0008572 name: obsolete nucleoplasmin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "nucleoplasmin ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006333 [Term] id: GO:0008573 name: obsolete peroxisome-assembly ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] comment: This term was made obsolete because it incorporates process information. synonym: "peroxisome-assembly ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0007031 [Term] id: GO:0008574 name: ATP-dependent microtubule motor activity, plus-end-directed namespace: molecular_function def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP." [EC:3.6.4.4, GOC:vw] synonym: "ATP-dependent plus-end-directed microtubule motor activity" EXACT [] synonym: "kinesin activity" RELATED [EC:3.6.4.4] synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4] synonym: "plus-end-directed ATP-dependent microtubule motor activity" EXACT [] synonym: "plus-end-directed kinesin ATPase activity" EXACT [] synonym: "plus-end-directed microtubule motor activity" BROAD [] xref: EC:3.6.4.4 xref: MetaCyc:3.6.4.4-RXN is_a: GO:1990939 ! ATP-dependent microtubule motor activity [Term] id: GO:0008575 name: obsolete proteasome ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] comment: This term was made obsolete because it mentions a component term in the term text string. synonym: "proteasome ATPase activity" EXACT [] is_obsolete: true consider: GO:0016887 [Term] id: GO:0008576 name: obsolete vesicle-fusing ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] comment: This term was made obsolete because it incorporates process information. synonym: "vesicle-fusing ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0016192 consider: GO:0061025 [Term] id: GO:0008579 name: JUN kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity [Term] id: GO:0008580 name: obsolete cytoskeletal regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. synonym: "cytoskeletal regulator activity" EXACT [] is_obsolete: true consider: GO:0007010 [Term] id: GO:0008581 name: obsolete ubiquitin-specific protease 5 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] comment: This term was made obsolete because it represents a gene product. synonym: "ubiquitin isopeptidase T activity" EXACT [] synonym: "ubiquitin-specific protease 5 activity" EXACT [] is_obsolete: true replaced_by: GO:0004843 [Term] id: GO:0008582 name: regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0051963 ! regulation of synapse assembly is_a: GO:1904396 ! regulation of neuromuscular junction development relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0008583 name: mystery cell differentiation namespace: biological_process def: "The process in which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0008584 name: male gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "testicular development" EXACT [GOC:sl] synonym: "testis development" EXACT [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046546 ! development of primary male sexual characteristics [Term] id: GO:0008585 name: female gonad development namespace: biological_process alt_id: GO:0061039 def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:dph, GOC:jid, GOC:tb] synonym: "ovarian development" RELATED [GOC:sl] synonym: "ovary development" RELATED [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0008586 name: imaginal disc-derived wing vein morphogenesis namespace: biological_process def: "The process in which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized." [GOC:mtg_sensu] synonym: "wing vein morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008587 name: imaginal disc-derived wing margin morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. synonym: "wing margin morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008589 name: regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0007226 alt_id: GO:0043109 def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of smoothened activity" RELATED [] synonym: "regulation of smoothened by patched" RELATED [] synonym: "regulation of smoothened receptor activity by patched" RELATED [] synonym: "regulation of smoothened signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0008591 name: regulation of Wnt signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of frizzled-2 signaling pathway" EXACT [] synonym: "regulation of frizzled-2 signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signaling pathway, calcium modulating pathway" EXACT [] synonym: "regulation of Wnt-activated signaling pathway, calcium modulating pathway" EXACT [GOC:signaling] is_a: GO:2000050 ! regulation of non-canonical Wnt signaling pathway relationship: regulates GO:0007223 ! Wnt signaling pathway, calcium modulating pathway [Term] id: GO:0008592 name: regulation of Toll signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "regulation of Tl signaling pathway" EXACT [] synonym: "regulation of Tl signalling pathway" EXACT [] synonym: "regulation of Toll signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0008593 name: regulation of Notch signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "regulation of N signaling pathway" EXACT [] synonym: "regulation of N signalling pathway" EXACT [] synonym: "regulation of Notch signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process in which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0008595 name: anterior/posterior axis specification, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0007351 ! tripartite regional subdivision [Term] id: GO:0008597 name: calcium-dependent protein serine/threonine phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] xref: reactome:R-HSA-139906 "Activation of BAD by calcineurin" is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008603 name: cAMP-dependent protein kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0008605 name: obsolete protein kinase CK2 regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "casein kinase II, regulator" EXACT [] synonym: "protein kinase CK2 regulator activity" EXACT [] synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] is_obsolete: true replaced_by: GO:0019887 [Term] id: GO:0008607 name: phosphorylase kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1 is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0008608 name: attachment of spindle microtubules to kinetochore namespace: biological_process alt_id: GO:0051313 def: "The process in which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] comment: This class covers all attachments of spindle microtubules to the kinetochore, including the many incorrect attachments which initially form and are later corrected to stable attachments with the correct orientation for segregation to proceed (sister chromatid biorientation). synonym: "amphotelic attachment" RELATED [] synonym: "attachment of spindle microtubules to chromosome" EXACT [] synonym: "bipolar attachment" RELATED [] synonym: "kinetochore microtubule interaction" BROAD [] synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore-microtubule interaction" BROAD [] synonym: "microtubule anchoring at kinetochore" EXACT [] synonym: "microtubule and chromosome interaction" BROAD [] synonym: "microtubule and kinetochore interaction" RELATED [] synonym: "microtubule capture" NARROW [] synonym: "spindle chromosome attachment" EXACT [] synonym: "spindle kinetochore attachment" EXACT [] synonym: "spindle-chromosome interaction" BROAD [] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0098813 ! nuclear chromosome segregation [Term] id: GO:0008609 name: alkylglycerone-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] synonym: "DHAP-AT" RELATED [EC:2.5.1.26] synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] xref: EC:2.5.1.26 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN xref: reactome:R-HSA-390427 "1-palmitoylglycerone phosphate + hexadecanol => O-hexadecylglycerone phosphate + palmitate" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0008611 name: ether lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] synonym: "ether lipid anabolism" EXACT [] synonym: "ether lipid biosynthesis" EXACT [] synonym: "ether lipid formation" EXACT [] synonym: "ether lipid synthesis" EXACT [] synonym: "plasmalogen biosynthetic process" NARROW [] is_a: GO:0046485 ! ether lipid metabolic process is_a: GO:0046504 ! glycerol ether biosynthetic process is_a: GO:0097384 ! cellular lipid biosynthetic process [Term] id: GO:0008612 name: peptidyl-lysine modification to peptidyl-hypusine namespace: biological_process alt_id: GO:0046515 def: "The modification of peptidyl-lysine to form hypusine, peptidyl-N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] synonym: "hypusine anabolism" EXACT [] synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] synonym: "hypusine biosynthesis" EXACT [] synonym: "hypusine biosynthetic process" EXACT [] synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] synonym: "hypusine formation" EXACT [] synonym: "hypusine formation from peptidyl-lysine" EXACT [] synonym: "hypusine synthesis" EXACT [] synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] synonym: "hypusinylation" EXACT [] synonym: "protein hypusination" EXACT [] xref: RESID:AA0116 is_a: GO:0009058 ! biosynthetic process is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0008613 name: diuretic hormone activity namespace: molecular_function def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008614 name: pyridoxine metabolic process namespace: biological_process alt_id: GO:0006773 def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [CHEBI:16709, GOC:curators] synonym: "pyridoxine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0042816 ! vitamin B6 metabolic process is_a: GO:0051186 ! cofactor metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0008615 name: pyridoxine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] synonym: "pyridoxine anabolism" EXACT [] synonym: "pyridoxine biosynthesis" EXACT [] synonym: "pyridoxine formation" EXACT [] synonym: "pyridoxine synthesis" EXACT [] is_a: GO:0008614 ! pyridoxine metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042819 ! vitamin B6 biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0008616 name: queuosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732] synonym: "queuosine anabolism" EXACT [] synonym: "queuosine biosynthesis" EXACT [] synonym: "queuosine formation" EXACT [] synonym: "queuosine synthesis" EXACT [] is_a: GO:0042455 ! ribonucleoside biosynthetic process is_a: GO:0046116 ! queuosine metabolic process [Term] id: GO:0008617 name: guanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732] synonym: "guanosine metabolism" EXACT [] is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0008618 name: 7-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732] synonym: "7-methylguanosine metabolism" EXACT [] is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0008619 name: obsolete RHEB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] comment: This term was made obsolete because it represents a gene product. synonym: "RHEB small monomeric GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 consider: GO:0051726 [Term] id: GO:0008622 name: epsilon DNA polymerase complex namespace: cellular_component def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0008623 name: CHRAC namespace: cellular_component alt_id: GO:0016588 def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and additional small histone fold subunits (generally two of these, but Xenopus has only one and some additional non-conserved subunits). CHRAC plays roles in the regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:15284901, PMID:16568949, PMID:21810179, PMID:9252192] synonym: "chromatin accessibility complex" EXACT [] synonym: "ISW2 complex" NARROW [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0008625 name: extrinsic apoptotic signaling pathway via death domain receptors namespace: biological_process def: "A series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with a ligand binding to a death domain receptor on the cell surface, and ends when the execution phase of apoptosis is triggered." [GOC:mah, GOC:mtg_apoptosis] comment: Gene products that may be annotated to this term include: 1) ligands such as FASL; 2) receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 3) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. Examples are TWEAK (TNF12) and FN14 (TNFRSF12A) (UniProt symbols O43508 and Q9NP84) in PMID:21525013. synonym: "death receptor-mediated apoptosis" NARROW [] synonym: "induction of apoptosis via death domain receptors" RELATED [] synonym: "induction of apoptosis via death receptors" EXACT [GOC:mah] is_a: GO:0097191 ! extrinsic apoptotic signaling pathway [Term] id: GO:0008626 name: granzyme-mediated apoptotic signaling pathway namespace: biological_process def: "A series of molecular signals induced by granzymes which triggers the apoptotic death of a cell. The pathway starts with reception of a granzyme signal, and ends when the execution phase of apoptosis is triggered. Granzymes are serine proteases that are secreted by cytotoxic T cells and natural killer cells to induce apoptosis in target cells." [GOC:mtg_apoptosis, PMID:17158907] synonym: "apoptotic signaling pathway in response to granzyme" RELATED [] synonym: "induction of apoptosis by granzyme" RELATED [] is_a: GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0008627 name: intrinsic apoptotic signaling pathway in response to osmotic stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to changes in intracellular ion homeostasis, and ends when the execution phase of apoptosis is triggered." [GOC:mtg_apoptosis, PMID:11454444, PMID:16483738] synonym: "induction of apoptosis by ionic changes" RELATED [] is_a: GO:0071470 ! cellular response to osmotic stress is_a: GO:0097193 ! intrinsic apoptotic signaling pathway [Term] id: GO:0008628 name: hormone-mediated apoptotic signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone, and which triggers the apoptotic signaling pathway in a cell. The pathway starts with reception of a hormone signal, and ends when the execution phase of apoptosis is triggered." [GOC:bf, GOC:mtg_apoptosis] comment: This term is placed under GO:0097190 apoptotic signaling pathway, rather than under one of its more specific children terms, to cover for the variety of apoptosis signaling mechanisms that different hormones may use. synonym: "apoptotic signaling pathway in response to hormone" RELATED [] synonym: "induction of apoptosis by hormones" RELATED [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0097190 ! apoptotic signaling pathway [Term] id: GO:0008630 name: intrinsic apoptotic signaling pathway in response to DNA damage namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced by the detection of DNA damage, and ends when the execution phase of apoptosis is triggered." [GOC:go_curators, GOC:mtg_apoptosis] synonym: "DNA damage response, signal transduction resulting in induction of apoptosis" RELATED [] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0097193 ! intrinsic apoptotic signaling pathway [Term] id: GO:0008631 name: intrinsic apoptotic signaling pathway in response to oxidative stress namespace: biological_process def: "A series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered." [GOC:ai, GOC:mtg_apoptosis] synonym: "induction of apoptosis by oxidative stress" RELATED [] synonym: "oxidative stress-induced intrinsic apoptotic signaling pathway" EXACT [GOC:bf] is_a: GO:0097193 ! intrinsic apoptotic signaling pathway relationship: part_of GO:0036473 ! cell death in response to oxidative stress [Term] id: GO:0008633 name: obsolete activation of pro-apoptotic gene products namespace: biological_process def: "OBSOLETE. The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because more specific terms were created. Additionally, the meaning of the term is ambiguous (some gene products may be involved in apoptosis, or not, depending on cell type, tissue, condition). synonym: "activation of pro-apoptotic gene products" EXACT [] synonym: "induction of pro-apoptotic gene products" RELATED [] is_obsolete: true [Term] id: GO:0008634 name: obsolete negative regulation of survival gene product expression namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:mtg_apoptosis, GOC:tb] comment: This term was made obsolete because the meaning of the term is ambiguous: the same gene product may or may not have a role in apoptosis depending on the cell type, tissue type, condition, etc. synonym: "down regulation of survival gene product activity" BROAD [] synonym: "down-regulation of survival gene product activity" BROAD [] synonym: "downregulation of survival gene product activity" BROAD [] synonym: "inhibition of survival gene product activity" NARROW [] synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "negative regulation of survival gene product expression" EXACT [] synonym: "negative regulation of survival gene products" BROAD [] is_obsolete: true [Term] id: GO:0008635 name: activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme cysteine-type endopeptidase in the context of an apoptotic process and is mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:mtg_apoptosis, GOC:tb, PMID:14744432, Wikipedia:Caspase] synonym: "activation of caspase activity by cytochrome c" NARROW [] synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb] is_a: GO:0006919 ! activation of cysteine-type endopeptidase activity involved in apoptotic process [Term] id: GO:0008636 name: obsolete activation of caspase activity by protein phosphorylation namespace: biological_process def: "OBSOLETE. Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, PMID:14744432, Wikipedia:Caspase] comment: This term was made obsolete because it is ill-defined: phosphorylation regulates the activity of caspases, but it doesn't activate them (caspases are only activated upon cleavage). synonym: "activation of caspase activity by protein amino acid phosphorylation" EXACT [GOC:bf] synonym: "activation of caspase activity by protein phosphorylation" EXACT [] synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb] is_obsolete: true [Term] id: GO:0008637 name: apoptotic mitochondrial changes namespace: biological_process def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah, GOC:mtg_apoptosis] comment: This term was created to reflect the fundamental role of the mitochondrial compartment in apoptosis. Most processes under this node occur during the signaling phase of apoptosis, but e.g. GO:0043653 'mitochondrial fragmentation involved in apoptotic process' cannot be confidently placed under the signaling phase. For this reason, the parent term GO:0008637 'apoptotic mitochondrial changes' is not linked to the signaling or execution phase specifically, but its descendants are when current knowledge allows for it. is_a: GO:0007005 ! mitochondrion organization relationship: part_of GO:0006915 ! apoptotic process [Term] id: GO:0008638 name: obsolete protein tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] comment: This term was made obsolete because it represents a biological process and a molecular function. synonym: "protein tagging activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0006464 consider: GO:0031386 [Term] id: GO:0008641 name: ubiquitin-like modifier activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] comment: Discussion of class label in this ticket: https://github.com/geneontology/go-ontology/issues/14208 subset: goslim_pir synonym: "small protein activating enzyme activity" NARROW [] is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "sugar transport" NARROW [] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0008645 name: hexose transmembrane transport namespace: biological_process alt_id: GO:0008646 alt_id: GO:0008647 alt_id: GO:0035428 def: "The process in which hexose is transported across a membrane. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "hexose membrane transport" RELATED [] synonym: "hexose transport" RELATED [] synonym: "high-affinity hexose transport" NARROW [] synonym: "low-affinity hexose transport" NARROW [] is_a: GO:0015749 ! monosaccharide transmembrane transport [Term] id: GO:0008648 name: obsolete tachykinin namespace: molecular_function def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "tachykinin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045987 consider: GO:0046878 consider: GO:0097755 [Term] id: GO:0008649 name: rRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0140102 ! catalytic activity, acting on a rRNA [Term] id: GO:0008650 name: rRNA (uridine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] xref: reactome:R-HSA-6793127 "MRM2 (FTSJ2) methylates uridine-1369 of 16S rRNA yielding 2'-O-methyluridine" is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity [Term] id: GO:0008651 name: obsolete actin polymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "actin polymerizing activity" EXACT [] is_obsolete: true consider: GO:0030041 consider: GO:0042802 [Term] id: GO:0008652 name: cellular amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732] synonym: "amino acid biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid anabolism" EXACT [] synonym: "cellular amino acid biosynthesis" EXACT [] synonym: "cellular amino acid formation" EXACT [] synonym: "cellular amino acid synthesis" EXACT [] xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0008653 name: lipopolysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732] synonym: "lipopolysaccharide metabolism" EXACT [] synonym: "LPS metabolic process" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:1903509 ! liposaccharide metabolic process [Term] id: GO:0008654 name: phospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid anabolism" EXACT [] synonym: "phospholipid biosynthesis" EXACT [] synonym: "phospholipid formation" EXACT [] synonym: "phospholipid synthesis" EXACT [] xref: MetaCyc:LIPASYN-PWY xref: MetaCyc:PHOSLIPSYN-PWY xref: MetaCyc:PHOSLIPSYN2-PWY is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0008655 name: pyrimidine-containing compound salvage namespace: biological_process def: "Any process that generates a pyrimidine-containing compound, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [CHEBI:39447, GOC:jl] subset: goslim_pir synonym: "pyrimidine salvage" RELATED [GOC:curators] is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0008656 name: cysteine-type endopeptidase activator activity involved in apoptotic process namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by a cysteine-type endopeptidase involved in the apoptotic process." [GOC:mah, GOC:mtg_apoptosis] comment: Examples of this are 1) granzymes that may bind to initiator caspases and cleave them, and 2) already active caspases, e.g. caspase 9, that cleave effector caspases. synonym: "caspase activator activity" BROAD [] xref: reactome:R-HSA-205117 "p75NTR:NADE promotes caspase2/3 activation" xref: reactome:R-HSA-449073 "Caspase-3 cleaves pro-interleukin-16" is_a: GO:0016505 ! peptidase activator activity involved in apoptotic process is_a: GO:0043028 ! cysteine-type endopeptidase regulator activity involved in apoptotic process [Term] id: GO:0008657 name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0042030 ! ATPase inhibitor activity is_a: GO:0072586 ! DNA topoisomerase (ATP-hydrolyzing) regulator activity [Term] id: GO:0008658 name: penicillin binding namespace: molecular_function def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: goslim_metagenomics is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0008659 name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.59, GOC:ai] synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.59 xref: RHEA:13097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008660 name: 1-aminocyclopropane-1-carboxylate deaminase activity namespace: molecular_function alt_id: GO:0018806 def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H(2)O = 2-oxobutanate + NH(4)(+)." [EC:3.5.99.7, RHEA:16933] comment: Note that this function was formerly EC:4.1.99.4. synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: KEGG:R00997 xref: MetaCyc:4.1.99.4-RXN xref: RHEA:16933 xref: UM-BBD_reactionID:r0357 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008661 name: 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(+) + pyruvate = 1-deoxy-D-xylulose 5-phosphate + CO(2)." [EC:2.2.1.7, RHEA:12605] synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] synonym: "DOXP synthase activity" EXACT [] synonym: "DXP-synthase activity" EXACT [] synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] xref: EC:2.2.1.7 xref: KEGG:R05636 xref: MetaCyc:DXS-RXN xref: RHEA:12605 is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0008662 name: 1-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] xref: EC:2.7.1.56 xref: MetaCyc:1PFRUCTPHOSN-RXN xref: RHEA:14213 is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0008663 name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: MetaCyc:CYCPHOSDIESTER-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0008664 name: 2'-5'-RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112] synonym: "2'-5' RNA ligase activity" EXACT [] is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0008666 name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydrodipicolinate + H(2)O + succinyl-CoA = L-2-succinylamino-6-oxopimelate + CoA." [EC:2.3.1.117, RHEA:17325] synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346] xref: EC:2.3.1.117 xref: KEGG:R04365 xref: MetaCyc:TETHYDPICSUCC-RXN xref: RHEA:17325 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008667 name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD(+) = 2,3-dihydroxybenzoate + H(+) + NADH." [EC:1.3.1.28, RHEA:23824] synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] xref: EC:1.3.1.28 xref: KEGG:R01505 xref: MetaCyc:DHBDEHYD-RXN xref: RHEA:23824 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008668 name: (2,3-dihydroxybenzoyl)adenylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP = 2,3-dihydroxybenzoyl 5'-adenylate + diphosphate." [EC:2.7.7.58, RHEA:20229] synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] xref: EC:2.7.7.58 xref: KEGG:R01504 xref: MetaCyc:DHBAMPLIG-RXN xref: RHEA:20229 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008670 name: 2,4-dienoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: MetaCyc:DIENOYLCOAREDUCT-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008671 name: 2-dehydro-3-deoxygalactonokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate + ATP = 6-phospho-2-dehydro-3-deoxy-D-galactonate + ADP + 2 H(+)." [EC:2.7.1.58, RHEA:16525] synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] xref: EC:2.7.1.58 xref: KEGG:R03387 xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN xref: RHEA:16525 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008672 name: 2-dehydro-3-deoxyglucarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] xref: EC:4.1.2.20 xref: MetaCyc:KDGALDOL-RXN xref: RHEA:10268 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008673 name: 2-dehydro-3-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H(+)." [EC:2.7.1.45, RHEA:14797] synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] xref: EC:2.7.1.45 xref: KEGG:R01541 xref: MetaCyc:DEOXYGLUCONOKIN-RXN xref: RHEA:14797 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008674 name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-2-dehydro-3-deoxy-D-galactonate = D-glyceraldehyde 3-phosphate + pyruvate." [EC:4.1.2.21, RHEA:24464] synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] xref: EC:4.1.2.21 xref: KEGG:R01064 xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN xref: RHEA:24464 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008675 name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] xref: EC:4.1.2.14 xref: MetaCyc:KDPGALDOL-RXN xref: RHEA:17089 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008676 name: 3-deoxy-8-phosphooctulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate + H(2)O + phosphoenolpyruvate = 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + 2 H(+) + phosphate." [EC:2.5.1.55, RHEA:14053] comment: Note that this function was formerly EC:4.1.2.16. synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] xref: EC:2.5.1.55 xref: KEGG:R03254 xref: MetaCyc:KDO-8PSYNTH-RXN xref: RHEA:14053 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008677 name: 2-dehydropantoate 2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NADP(+) = 2-dehydropantoate + H(+) + NADPH." [EC:1.1.1.169, RHEA:16233] synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] xref: EC:1.1.1.169 xref: KEGG:R02472 xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN xref: RHEA:16233 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008678 name: 2-deoxy-D-gluconate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] xref: EC:1.1.1.125 xref: MetaCyc:KDUD-RXN xref: RHEA:12160 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008679 name: 2-hydroxy-3-oxopropionate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] synonym: "tartronate semialdehyde reductase (NADPH) activity" EXACT [EC:1.1.1.60] xref: EC:1.1.1.60 xref: MetaCyc:TSA-REDUCT-RXN xref: RHEA:18841 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008681 name: 2-octaprenyl-6-methoxyphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenyl-6-methoxyphenol + O2 + 4 H+ = 2-octaprenyl-6-methoxy-1,4-benzoquinol + H2O." [MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN] xref: EC:1.14.14 xref: MetaCyc:2-OCTAPRENYL-6-METHOXYPHENOL-HYDROX-RXN xref: RHEA:29407 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008682 name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] synonym: "demethoxy-ubiquinone hydroxylase" RELATED [GOC:vw] synonym: "demethoxyubiquinone monooxygenase" RELATED [GOC:vw] xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008683 name: 2-oxoglutarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + H(+) = CO(2) + succinate semialdehyde." [EC:4.1.1.71, RHEA:10524] synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] xref: EC:4.1.1.71 xref: KEGG:R00272 xref: MetaCyc:RXN-7774 xref: RHEA:10524 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008684 name: 2-oxopent-4-enoate hydratase activity namespace: molecular_function alt_id: GO:0018821 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] synonym: "OEH activity" EXACT [EC:4.2.1.80] xref: EC:4.2.1.80 xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN xref: RHEA:22580 xref: UM-BBD_enzymeID:e0078 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008685 name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-CDP-2-C-methyl-D-erythritol 2-phosphate = 2-C-methyl-D-erythritol 2,4-cyclic diphosphate + CMP." [EC:4.6.1.12, RHEA:23864] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] synonym: "MECP synthase activity" EXACT [] xref: EC:4.6.1.12 xref: KEGG:R05637 xref: MetaCyc:RXN0-302 xref: RHEA:23864 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0008686 name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = (2S)-2-hydroxy-3-oxobutyl phosphate + formate + H(+)." [EC:4.1.99.12, RHEA:18457] xref: EC:4.1.99.12 xref: KEGG:R07281 xref: MetaCyc:DIOHBUTANONEPSYN-RXN xref: RHEA:18457 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0008687 name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O(2) = 5-formyl-2-hydroxyhepta-2,4-dienedioate + H(+)." [EC:1.13.11.15, RHEA:15633] synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] xref: EC:1.13.11.15 xref: KEGG:R03303 xref: MetaCyc:1.13.11.15-RXN xref: RHEA:15633 xref: UM-BBD_reactionID:r0364 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008688 name: 3-(3-hydroxyphenyl)propionate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(3-hydroxyphenyl)propionate + NADH + oxygen + H+ = 3-(2,3-dihydroxyphenyl)propionate + NAD+ + H2O." [MetaCyc:MHPHYDROXY-RXN] xref: EC:1.14.13 xref: KEGG:R06786 xref: MetaCyc:MHPHYDROXY-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008689 name: 3-demethylubiquinone-9 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [GOC:dph] synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] xref: EC:2.1.1.64 xref: MetaCyc:DHHB-METHYLTRANSFER-RXN xref: RHEA:17049 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0061542 ! 3-demethylubiquinone-n 3-O-methyltransferase activity [Term] id: GO:0008690 name: 3-deoxy-manno-octulosonate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] xref: EC:2.7.7.38 xref: MetaCyc:CPM-KDOSYNTH-RXN xref: RHEA:23448 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008691 name: 3-hydroxybutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "BHBD activity" EXACT [EC:1.1.1.157] synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] xref: EC:1.1.1.157 xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN xref: RHEA:16197 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008692 name: 3-hydroxybutyryl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] xref: EC:5.1.2.3 xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN xref: RHEA:21760 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008693 name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60] synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "FabA" RELATED [EC:4.2.1.60] synonym: "HDDase activity" EXACT [EC:4.2.1.60] xref: EC:4.2.1.60 is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0008694 name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity namespace: molecular_function alt_id: GO:0019167 def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "PPHB decarboxylase activity" EXACT [] synonym: "UbiD" RELATED [] synonym: "UbiX" RELATED [] xref: EC:4.1.1.98 xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN xref: RHEA:27778 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008695 name: 3-phenylpropionate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: MetaCyc:HCAMULTI-RXN xref: RHEA:20357 xref: UM-BBD_enzymeID:e0307 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008696 name: 4-amino-4-deoxychorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = 4-aminobenzoate + H(+) + pyruvate." [EC:4.1.3.38, RHEA:16201] comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] synonym: "aminodeoxychorismate lyase activity" EXACT [] synonym: "enzyme X activity" RELATED [EC:4.1.3.38] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase" RELATED [] xref: EC:4.1.3.38 xref: KEGG:R05553 xref: MetaCyc:ADCLY-RXN xref: RHEA:16201 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008697 name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydro-4-deoxy-D-glucuronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17, RHEA:23896] synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] xref: EC:5.3.1.17 xref: KEGG:R04383 xref: MetaCyc:5.3.1.17-RXN xref: RHEA:23896 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008700 name: 4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] xref: EC:4.1.3.16 xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN xref: reactome:R-HSA-6784423 "HOGA1 tetramer aldol-cleaves 4-OH-2-oxoglutarate (HOG) to glyoxylate and pyruvate" xref: RHEA:18169 is_a: GO:0016832 ! aldehyde-lyase activity is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008701 name: 4-hydroxy-2-oxovalerate aldolase activity namespace: molecular_function alt_id: GO:0018804 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = acetaldehyde + pyruvate." [EC:4.1.3.39, RHEA:22624] synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "DmpG" RELATED [EC:4.1.3.39] synonym: "HOA" RELATED [EC:4.1.3.39] xref: EC:4.1.3.39 xref: KEGG:R00750 xref: MetaCyc:MHPELY-RXN xref: RHEA:22624 xref: UM-BBD_enzymeID:e0077 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008703 name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP(+) = 5-amino-6-(5-phosphoribosylamino)uracil + H(+) + NADPH." [EC:1.1.1.193, RHEA:17845] synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] xref: EC:1.1.1.193 xref: KEGG:R03458 xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN xref: RHEA:17845 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008704 name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity namespace: molecular_function alt_id: GO:0018843 def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] synonym: "HHDD isomerase activity" EXACT [] synonym: "hpaG-1" RELATED [] synonym: "hpaG1" RELATED [] xref: EC:5.3.3.10 xref: MetaCyc:5.3.3.10-RXN xref: RHEA:18813 xref: UM-BBD_reactionID:r0366 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008705 name: methionine synthase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-5-methyl-5,6,7,8-tetrahydrofolate + L-homocysteine = (6S)-5,6,7,8-tetrahydrofolate + L-methionine." [EC:2.1.1.13, RHEA:11172] synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] synonym: "MetH" RELATED [EC:2.1.1.13] synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] xref: EC:2.1.1.13 xref: KEGG:R00946 xref: MetaCyc:HOMOCYSMETB12-RXN xref: reactome:R-HSA-174374 "MTR transfers CH3 from MeCbl to HCYS" xref: reactome:R-HSA-3149539 "MTR transfers CH3 group from MTHF to cob(I)alamin" xref: RHEA:11172 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0008706 name: 6-phospho-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] xref: EC:3.2.1.86 xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN xref: RHEA:10772 is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0008707 name: 4-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] synonym: "6-phytase activity" EXACT [] synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] synonym: "phytase activity" BROAD [EC:3.1.3.26] synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] xref: EC:3.1.3.26 xref: MetaCyc:6-PHYT-RXN xref: RHEA:20960 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008709 name: cholate 7-alpha-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cholate + NAD(+) = 3alpha,12alpha-dihydroxy-7-oxo-5beta-cholanate + H(+) + NADH." [EC:1.1.1.159, RHEA:19409] synonym: "7-alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] synonym: "7alpha-hydroxy steroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" BROAD [EC:1.1.1.159] xref: EC:1.1.1.159 xref: KEGG:R02792 xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN xref: RHEA:19409 is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008710 name: 8-amino-7-oxononanoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H(+) + pimelyl-CoA = 8-amino-7-oxononanoate + CO(2) + CoA." [EC:2.3.1.47, RHEA:20712] synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "AONS activity" EXACT [EC:2.3.1.47] xref: EC:2.3.1.47 xref: KEGG:R03210 xref: MetaCyc:7KAPSYN-RXN xref: RHEA:20712 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008711 name: obsolete ADP-L-glycero-D-manno-heptose synthase activity namespace: molecular_function def: "OBSOLETE." [GOC:curators] comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). synonym: "ADP-L-glycero-D-manno-heptose synthase activity" EXACT [] is_obsolete: true consider: GO:0033785 consider: GO:0033786 [Term] id: GO:0008712 name: ADP-glyceromanno-heptose 6-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20, RHEA:17577] synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] xref: EC:5.1.3.20 xref: KEGG:R05176 xref: MetaCyc:5.1.3.20-RXN xref: RHEA:17577 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008713 name: ADP-heptose-lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: heptosyl-KDO2-lipid A + ADP-L-glycero-beta-D-manno-heptose = heptosyl2-KDO2-lipid A + ADP + H+." [MetaCyc:RXN0-5061] synonym: "ADP-heptose:LPS heptosyltransferase activity" EXACT [MetaCyc:LIPA-CORESYN-PWY] xref: MetaCyc:RXN0-5061 is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0008714 name: AMP nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H(2)O = D-ribose 5-phosphate + adenine." [EC:3.2.2.4, RHEA:20129] synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] xref: EC:3.2.2.4 xref: KEGG:R00182 xref: MetaCyc:AMP-NUCLEOSID-RXN xref: RHEA:20129 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008715 name: CDP-diacylglycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + H(2)O = a phosphatidate + CMP + 2 H(+)." [EC:3.6.1.26, RHEA:15221] synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] xref: EC:3.6.1.26 xref: KEGG:R01797 xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN xref: RHEA:15221 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008716 name: D-alanine-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2 D-alanine + ATP = D-alanyl-D-alanine + ADP + 2 H(+) + phosphate." [EC:6.3.2.4, RHEA:11224] synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] xref: EC:6.3.2.4 xref: KEGG:R01150 xref: MetaCyc:DALADALALIG-RXN xref: RHEA:11224 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008717 name: obsolete D-alanyl-D-alanine endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "D-alanyl-D-alanine endopeptidase activity" EXACT [] synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] xref: EC:3.4.99 is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0008718 name: D-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] xref: EC:1.4.99.1 xref: MetaCyc:DAADEHYDROG-RXN xref: RHEA:18125 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0008719 name: dihydroneopterin triphosphate 2'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] xref: EC:5.1.99.7 xref: MetaCyc:H2NTPEPIM-RXN xref: RHEA:28346 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0008720 name: D-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + NAD(+) = H(+) + NADH + pyruvate." [EC:1.1.1.28, RHEA:16369] synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] xref: EC:1.1.1.28 xref: KEGG:R00704 xref: MetaCyc:DLACTDEHYDROGNAD-RXN xref: RHEA:16369 is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008721 name: D-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] comment: Note that this function was formerly EC:4.3.1.14. synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: MetaCyc:DSERDEAM-RXN xref: reactome:R-HSA-9014741 "SRR dimer:PXLP deaminates D-Ser" xref: reactome:R-HSA-9034539 "SRR dimer:PXLP deaminates L-Ser" xref: RHEA:13977 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008724 name: obsolete DNA topoisomerase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] comment: This term was made obsolete because it represents a gene product. synonym: "DNA topoisomerase IV activity" EXACT [] is_obsolete: true replaced_by: GO:0003918 [Term] id: GO:0008725 name: DNA-3-methyladenine glycosylase activity namespace: molecular_function def: "Catalysis of the reaction: DNA containing 3-methyladenine + H2O = DNA with abasic site + 3-methyladenine. This reaction is the hydrolysis of DNA by cleavage of the N-C1' glycosidic bond between the damaged DNA 3-methyladenine and the deoxyribose sugar to remove the 3-methyladenine, leaving an abasic site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosylase I activity" EXACT [] xref: EC:3.2.2.20 xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.20-RXN xref: MetaCyc:3.2.2.21-RXN is_a: GO:0043733 ! DNA-3-methylbase glycosylase activity [Term] id: GO:0008726 name: alkanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + sulfite + H2O + FMN." [MetaCyc:RXN0-280] synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] synonym: "alkanesulphonate monooxygenase activity" EXACT [] synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: MetaCyc:RXN0-280 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008727 name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-alpha-D-mannose + H2O = GDP + D-mannose + H+." [MetaCyc:GDPMANMANHYDRO-RXN] xref: MetaCyc:GDPMANMANHYDRO-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0008728 name: GTP diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "GPSI" RELATED [EC:2.7.6.5] synonym: "GPSII" RELATED [EC:2.7.6.5] synonym: "GTP pyrophosphokinase activity" EXACT [] synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] synonym: "stringent factor activity" RELATED [EC:2.7.6.5] xref: EC:2.7.6.5 xref: MetaCyc:GTPPYPHOSKIN-RXN xref: RHEA:22088 is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0008730 name: L(+)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-tartrate = H(2)O + oxaloacetate." [EC:4.2.1.32, RHEA:15413] synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] xref: EC:4.2.1.32 xref: KEGG:R00339 xref: MetaCyc:LTARTDEHYDRA-RXN xref: RHEA:15413 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008732 name: L-allo-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2 xref: MetaCyc:LTAA-RXN is_a: GO:0004793 ! threonine aldolase activity [Term] id: GO:0008733 name: L-arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4, RHEA:14821] synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] xref: EC:5.3.1.4 xref: KEGG:R01761 xref: MetaCyc:ARABISOM-RXN xref: RHEA:14821 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008734 name: L-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.16] synonym: "L-aspartate:oxygen oxidoreductase" EXACT [EC:1.4.3.16] xref: EC:1.4.3.16 xref: MetaCyc:L-ASPARTATE-OXID-RXN xref: MetaCyc:RXN-9772 xref: RHEA:25876 is_a: GO:0001716 ! L-amino-acid oxidase activity is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008735 name: carnitine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-carnitine = crotono-betaine + H(2)O." [EC:4.2.1.89, RHEA:14577] synonym: "L-carnitine dehydratase activity" EXACT [] synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] xref: EC:4.2.1.89 xref: KEGG:R01925 xref: MetaCyc:CARNDEHYDRA-RXN xref: RHEA:14577 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008736 name: L-fucose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] xref: EC:5.3.1.25 xref: MetaCyc:FUCISOM-RXN xref: RHEA:17233 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008737 name: L-fuculokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose + ATP = L-fuculose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.51, RHEA:12376] synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] xref: EC:2.7.1.51 xref: KEGG:R03241 xref: MetaCyc:FUCULOKIN-RXN xref: RHEA:12376 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008738 name: L-fuculose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose 1-phosphate = (S)-lactaldehyde + glycerone phosphate." [EC:4.1.2.17, RHEA:12933] synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] xref: EC:4.1.2.17 xref: KEGG:R02262 xref: MetaCyc:FUCPALDOL-RXN xref: RHEA:12933 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008740 name: L-rhamnose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14, RHEA:23160] synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] xref: EC:5.3.1.14 xref: KEGG:R02437 xref: MetaCyc:RHAMNISOM-RXN xref: RHEA:23160 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008741 name: ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: MetaCyc:RIBULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008742 name: L-ribulose-phosphate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.4, RHEA:22368] synonym: "AraD" RELATED [EC:5.1.3.4] synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] synonym: "L-Ru5P" RELATED [EC:5.1.3.4] synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] xref: EC:5.1.3.4 xref: KEGG:R05850 xref: MetaCyc:RIBULPEPIM-RXN xref: RHEA:22368 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008743 name: L-threonine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + NAD(+) = aminoacetone + CO(2) + NADH." [EC:1.1.1.103, RHEA:25657] synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] synonym: "threonine 3-dehydrogenase activity" BROAD [] synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] xref: EC:1.1.1.103 xref: KEGG:R01465 xref: MetaCyc:THREODEHYD-RXN xref: reactome:R-HSA-6798667 "TDH tetramer oxidises L-Thr to 2A-3OB" xref: RHEA:25657 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008744 name: L-xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] xref: EC:2.7.1.53 xref: MetaCyc:LYXK-RXN xref: RHEA:18869 is_a: GO:0004856 ! xylulokinase activity [Term] id: GO:0008745 name: N-acetylmuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28, PMID:22748813] synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] xref: EC:3.5.1.28 xref: MetaCyc:3.5.1.28-RXN xref: reactome:R-HSA-6799977 "PGLYRP2 hydrolyzes bacterial peptidoglycan" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0008746 name: NAD(P)+ transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] xref: EC:1.6.1.1 xref: KEGG:R00112 xref: reactome:R-HSA-450971 "NADPH + NAD+ + H+ [cytosol] => NADP+ + NADH + H+ [mitochondrial matrix]" xref: RHEA:11692 is_a: GO:0016652 ! oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor [Term] id: GO:0008747 name: N-acetylneuraminate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3, RHEA:23296] synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] synonym: "NALase activity" EXACT [EC:4.1.3.3] synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "NPL" RELATED [EC:4.1.3.3] synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] xref: EC:4.1.3.3 xref: KEGG:R01811 xref: MetaCyc:ACNEULY-RXN xref: reactome:R-HSA-4085217 "NPL cleaves Neu5Ac,Neu5Gc to ManNAc,ManNGc and pyruvate" xref: RHEA:23296 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008748 name: N-ethylmaleimide reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-ethylmaleimide + NADPH + 2 H+ = N-ethylsuccinimide + NADP+." [MetaCyc:RXN0-5101] xref: EC:1 xref: MetaCyc:RXN0-5101 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008750 name: NAD(P)+ transhydrogenase (AB-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf] synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] xref: EC:1.6.1.2 xref: MetaCyc:1.6.1.2-RXN is_a: GO:0008746 ! NAD(P)+ transhydrogenase activity [Term] id: GO:0008751 name: obsolete NAD(P)H dehydrogenase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a redundant grouping term with only one child. synonym: "NAD(P)H dehydrogenase" EXACT [] is_obsolete: true consider: GO:0016651 [Term] id: GO:0008752 name: FMN reductase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0008753 name: NADPH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + a quinone = NADP+ + a quinol." [EC:1.6.5.10] synonym: "NADPH oxidase" BROAD [EC:1.6.5.10] synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.5.10] synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.5.10] xref: EC:1.6.5.10 xref: KEGG:R07359 xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN xref: RHEA:13149 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0008754 name: O antigen ligase activity namespace: molecular_function def: "Catalysis of the reaction: Lipid A-core + colanic acid = MLPS." [MetaCyc:RXN0-5294] xref: MetaCyc:RXN0-5294 is_a: GO:0016874 ! ligase activity [Term] id: GO:0008755 name: O antigen polymerase activity namespace: molecular_function def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra- and pentasaccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, PMID:12045108] synonym: "O-antigen polymerase activity" EXACT [] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008756 name: o-succinylbenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2-succinylbenzoate + ATP + CoA = 2-succinylbenzoyl-CoA + AMP + diphosphate." [EC:6.2.1.26] synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] xref: EC:6.2.1.26 xref: KEGG:R04030 xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN xref: RHEA:17009 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008757 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008758 name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] xref: EC:3.6.1 xref: MetaCyc:LIPIDXSYNTHESIS-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008759 name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the removal of an acetyl group from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] xref: EC:3.5.1.108 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008760 name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-alpha-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7, RHEA:18681] synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] xref: EC:2.5.1.7 xref: KEGG:R00660 xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN xref: RHEA:18681 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008761 name: UDP-N-acetylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] xref: EC:5.1.3.14 xref: MetaCyc:UDPGLCNACEPIM-RXN xref: reactome:R-HSA-4085021 "GNE hydrolyzes/epimerises UDP-GlcNAc to ManNAc and UDP" xref: RHEA:17213 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008762 name: UDP-N-acetylmuramate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] synonym: "MurB reductase" RELATED [EC:1.1.1.158] synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158] xref: EC:1.1.1.158 xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN xref: RHEA:12248 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008763 name: UDP-N-acetylmuramate-L-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + ATP + UDP-N-acetylmuramate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8, RHEA:23372] synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] xref: EC:6.3.2.8 xref: KEGG:R03193 xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN xref: RHEA:23372 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008764 name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: D-glutamate + ATP + UDP-N-acetylmuramoyl-L-alanine = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9, RHEA:16429] synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] xref: EC:6.3.2.9 xref: KEGG:R02783 xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN xref: RHEA:16429 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008765 name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate = ADP + 2 H(+) + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-gamma-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13, RHEA:23676] synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] xref: EC:6.3.2.13 xref: KEGG:R02788 xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN xref: RHEA:23676 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008766 name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). xref: EC:6.3.2 xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008767 name: UDP-galactopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] xref: EC:5.4.99.9 xref: MetaCyc:GALPMUT-RXN xref: RHEA:24132 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0008768 name: UDP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] xref: EC:3.6.1.45 xref: MetaCyc:UDPSUGARHYDRO-RXN xref: reactome:R-HSA-6810464 "NUDT14 hydrolyses UDP-Glc to G1P and UMP" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008769 name: obsolete X-His dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "carnosinase activity" RELATED [EC:3.4.13.3] synonym: "dipeptidase M" RELATED [EC:3.4.13.3] synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] synonym: "X-His dipeptidase activity" EXACT [] synonym: "Xaa-His dipeptidase activity" EXACT [] xref: EC:3.4.13.3 xref: MetaCyc:3.4.13.3-RXN is_obsolete: true consider: GO:0008235 consider: GO:0016805 [Term] id: GO:0008770 name: [acyl-carrier-protein] phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] synonym: "ACP phosphodiesterase activity" EXACT [] synonym: "AcpH" RELATED [EC:3.1.4.14] synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: MetaCyc:3.1.4.14-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008771 name: [citrate (pro-3S)-lyase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: KEGG:R04449 xref: MetaCyc:CITC-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008772 name: [isocitrate dehydrogenase (NADP+)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] synonym: "ICDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase/phosphatase activity" BROAD [EC:2.7.11.5] synonym: "IDH-K/P" RELATED [EC:2.7.11.5] synonym: "IDHK/P" BROAD [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" BROAD [EC:2.7.11.5] xref: EC:2.7.11.5 xref: MetaCyc:PHOSICITDEHASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0008773 name: [protein-PII] uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: MetaCyc:URITRANS-RXN is_a: GO:0070569 ! uridylyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008774 name: acetaldehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] synonym: "ADA" RELATED [EC:1.2.1.10] synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] synonym: "DmpF" RELATED [EC:1.2.1.10] xref: EC:1.2.1.10 xref: MetaCyc:ACETALD-DEHYDROG-RXN xref: RHEA:23288 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008775 name: acetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] xref: EC:2.8.3.8 xref: MetaCyc:ACECOATRANS-RXN xref: reactome:R-HSA-2066788 "Formation of DHA-CoA catalysed by 3-ketoacyl-CoA thiolase" xref: RHEA:13381 xref: UM-BBD_enzymeID:e0012 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008776 name: acetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] synonym: "acetokinase activity" EXACT [EC:2.7.2.1] synonym: "AckA" RELATED [EC:2.7.2.1] synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: MetaCyc:ACETATEKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008777 name: acetylornithine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] xref: EC:3.5.1.16 xref: MetaCyc:ACETYLORNDEACET-RXN xref: RHEA:15941 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008779 name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: MetaCyc:ACYLGPEACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008780 name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008781 name: N-acylneuraminate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] xref: EC:2.7.7.43 xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN xref: reactome:R-HSA-4084982 "CMAS transfers CMP from CTP to Neu5Ac, forming CMP-Neu5Ac" xref: RHEA:11344 is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008782 name: adenosylhomocysteine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008783 name: agmatinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H(2)O = putrescine + urea." [EC:3.5.3.11, RHEA:13929] synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] synonym: "SpeB" RELATED [EC:3.5.3.11] xref: EC:3.5.3.11 xref: KEGG:R01157 xref: MetaCyc:AGMATIN-RXN xref: reactome:R-HSA-350604 "Agmatine + H2O <=> putrescine + urea" xref: RHEA:13929 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0008784 name: alanine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1, RHEA:20249] synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] xref: EC:5.1.1.1 xref: KEGG:R00401 xref: MetaCyc:ALARACECAT-RXN xref: RHEA:20249 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008785 name: alkyl hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_reactionID:r0684] xref: reactome:R-HSA-1222526 "AhpC reduces peroxidated lipids" xref: UM-BBD_reactionID:r0684 is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0008786 name: allose 6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] xref: MetaCyc:RXN0-303 xref: RHEA:28430 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008787 name: allose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] synonym: "allokinase activity" EXACT [EC:2.7.1.55] synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] xref: EC:2.7.1.55 xref: MetaCyc:ALLOSE-KINASE-RXN xref: RHEA:14805 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008788 name: alpha,alpha-phosphotrehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] xref: EC:3.2.1.93 xref: MetaCyc:TRE6PHYDRO-RXN xref: RHEA:23008 is_a: GO:0015927 ! trehalase activity [Term] id: GO:0008789 name: altronate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.7, RHEA:15957] synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] xref: EC:4.2.1.7 xref: KEGG:R01540 xref: MetaCyc:ALTRODEHYDRAT-RXN xref: RHEA:15957 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008790 name: arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] xref: EC:5.3.1.3 xref: MetaCyc:DARABISOM-RXN xref: RHEA:13849 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008791 name: arginine N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] synonym: "AOST activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "AST activity" EXACT [EC:2.3.1.109] synonym: "AstA" RELATED [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] xref: EC:2.3.1.109 xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN xref: RHEA:15185 is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008792 name: arginine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H(+) = agmatine + CO(2)." [EC:4.1.1.19, RHEA:17641] synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] synonym: "SpeA" RELATED [EC:4.1.1.19] xref: EC:4.1.1.19 xref: KEGG:R00566 xref: MetaCyc:ARGDECARBOX-RXN xref: reactome:R-HSA-350598 "Arginine<=>Agmatine+CO2" xref: RHEA:17641 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008793 name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] synonym: "ArAT" RELATED [EC:2.6.1.57] synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] synonym: "aromatic amino acid transferase activity" EXACT [] synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: MetaCyc:2.6.1.57-RXN xref: UM-BBD_reactionID:r0297 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008794 name: arsenate reductase (glutaredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: MetaCyc:RXN-982 xref: UM-BBD_reactionID:r0635 is_a: GO:0030611 ! arsenate reductase activity is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor [Term] id: GO:0008795 name: NAD+ synthase activity namespace: molecular_function alt_id: GO:0008749 alt_id: GO:0016965 def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD synthase (AMP-forming)" EXACT [] synonym: "NAD synthase activity" EXACT [] synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] xref: EC:6.3.1.5 xref: MetaCyc:NAD-SYNTH-NH3-RXN xref: RHEA:21188 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008796 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] xref: EC:3.6.1 is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0008797 name: aspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] synonym: "aspartase activity" EXACT [EC:4.3.1.1] synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] xref: EC:4.3.1.1 xref: MetaCyc:ASPARTASE-RXN xref: RHEA:16601 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008798 name: beta-aspartyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] xref: EC:3.4.19.5 xref: MetaCyc:3.4.19.5-RXN xref: reactome:R-HSA-5692495 "BACE1 cleaves APP(18-770) to APP(18-671) and APP(672-770)" xref: reactome:R-HSA-5696365 "ASRGL1 hydrolyses aspartame to L-Asp, L-Phe" is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0008800 name: beta-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] synonym: "neutrapen" RELATED [EC:3.5.2.6] synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0008801 name: beta-phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6, RHEA:20113] synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] xref: EC:5.4.2.6 xref: KEGG:R02728 xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN xref: RHEA:20113 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008802 name: betaine-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] synonym: "BADH activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] synonym: "BetB" RELATED [EC:1.2.1.8] xref: EC:1.2.1.8 xref: MetaCyc:BADH-RXN xref: reactome:R-HSA-6797955 "ALDH7A1 oxidises BETALD to BET" xref: RHEA:15305 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0008803 name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-adenosyl) tetraphosphate + H(2)O = 2 ADP + 2 H(+)." [EC:3.6.1.41, RHEA:24252] synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] xref: EC:3.6.1.41 xref: KEGG:R00125 xref: MetaCyc:3.6.1.41-RXN xref: RHEA:24252 is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0008804 name: carbamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "CKase activity" EXACT [EC:2.7.2.2] xref: EC:2.7.2.2 xref: MetaCyc:CARBAMATE-KINASE-RXN xref: RHEA:10152 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008805 name: carbon-monoxide oxygenase activity namespace: molecular_function alt_id: GO:0018999 alt_id: GO:0047767 def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] synonym: "carbon monoxide oxygenase activity" EXACT [] synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: MetaCyc:1.2.2.4-RXN xref: UM-BBD_reactionID:r0650 xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008806 name: carboxymethylenebutenolidase activity namespace: molecular_function alt_id: GO:0018735 def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] xref: EC:3.1.1.45 xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN xref: RHEA:12372 xref: UM-BBD_enzymeID:e0066 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008807 name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] xref: EC:2.7.8.23 xref: MetaCyc:2.7.8.23-RXN xref: RHEA:14045 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008808 name: cardiolipin synthase activity namespace: molecular_function alt_id: GO:0043788 def: "Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl] synonym: "cardiolipin synthase 2 activity" RELATED [] synonym: "cardiolipin synthetase 2 activity" RELATED [] synonym: "cardiolipin synthetase activity" BROAD [] synonym: "diphosphatidylglycerol synthase activity" EXACT [] xref: EC:2.7.8 xref: MetaCyc:CARDIOLIPSYN-RXN xref: RHEA:31451 is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0008809 name: carnitine racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] xref: EC:5.1 xref: MetaCyc:CARNRACE-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008810 name: cellulase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] synonym: "alkali cellulase activity" NARROW [EC:3.2.1.4] synonym: "avicelase activity" RELATED [EC:3.2.1.4] synonym: "beta-1,4-endoglucan hydrolase activity" BROAD [EC:3.2.1.4] synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] synonym: "celluase A" RELATED [EC:3.2.1.4] synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] synonym: "cellulase A 3" RELATED [EC:3.2.1.4] synonym: "cellulosin AP" RELATED [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanase activity" BROAD [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanohydrolase activity" BROAD [EC:3.2.1.4] synonym: "endo-1,4-beta-glucanase activity" BROAD [EC:3.2.1.4] synonym: "endoglucanase activity" BROAD [EC:3.2.1.4] synonym: "endoglucanase D" RELATED [EC:3.2.1.4] synonym: "pancellase SS" RELATED [EC:3.2.1.4] xref: EC:3.2.1.4 xref: MetaCyc:RXN-2043 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0008811 name: chloramphenicol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: chloramphenicol + acetyl-CoA = chloramphenicol 3-acetate + CoA." [EC:2.3.1.28, RHEA:18421] synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "CAT I" RELATED [EC:2.3.1.28] synonym: "CAT II" RELATED [EC:2.3.1.28] synonym: "CAT III" RELATED [EC:2.3.1.28] synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] xref: EC:2.3.1.28 xref: KEGG:R03065 xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN xref: RHEA:18421 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008812 name: choline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde." [EC:1.1.99.1, RHEA:17433] synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] xref: EC:1.1.99.1 xref: KEGG:R01025 xref: MetaCyc:CHD-RXN xref: reactome:R-HSA-6797961 "CHDH oxidises Cho to BETALD" xref: RHEA:17433 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0008813 name: chorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, RHEA:16505] synonym: "4-hydroxybenzoate synthetase activity" EXACT [] synonym: "chorismate pyruvate lyase activity" EXACT [] synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] synonym: "CL" RELATED [EC:4.1.3.40] synonym: "CPL" RELATED [EC:4.1.3.40] synonym: "UbiC" RELATED [EC:4.1.3.40] xref: EC:4.1.3.40 xref: KEGG:R01302 xref: MetaCyc:CHORPYRLY-RXN xref: RHEA:16505 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008814 name: citrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] xref: EC:2.8.3.10 xref: MetaCyc:CITTRANS-RXN xref: RHEA:19405 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008815 name: citrate (pro-3S)-lyase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6, RHEA:10760] synonym: "citrase activity" EXACT [EC:4.1.3.6] synonym: "citratase activity" EXACT [EC:4.1.3.6] synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] synonym: "citrate lyase activity" EXACT [] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] synonym: "citritase activity" EXACT [EC:4.1.3.6] xref: EC:4.1.3.6 xref: KEGG:R00362 xref: MetaCyc:CITLY-RXN xref: RHEA:10760 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008816 name: citryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] xref: EC:4.1.3.34 xref: MetaCyc:CITRYLY-RXN xref: RHEA:20812 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008817 name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] synonym: "CobA" RELATED [EC:2.5.1.17] synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] xref: EC:2.5.1.17 xref: MetaCyc:COBALADENOSYLTRANS-RXN xref: reactome:R-HSA-3159253 "MMAB transfers adenosyl group from ATP to cob(I)alamin" xref: RHEA:14725 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008818 name: cobalamin 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] xref: MetaCyc:COBALAMIN5PSYN-RXN xref: RHEA:23560 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008819 name: cobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008820 name: cobinamide phosphate guanylyltransferase activity namespace: molecular_function alt_id: GO:0043753 def: "Catalysis of the reaction: adenosylcobinamide phosphate + GTP + 2 H(+) = adenosylcobinamide-GDP + diphosphate." [EC:2.7.7.62, RHEA:22712] synonym: "adenosylcobinamide kinase/adenosylcobinamide-phosphate guanylyltransferase" BROAD [] synonym: "adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "AdoCbi kinase/AdoCbi-phosphate guanylyltransferase" BROAD [] synonym: "CobU" RELATED [] synonym: "GTP:adenosylcobinamide-phosphate guanylyltransferase activity" EXACT [] synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] xref: EC:2.7.7.62 xref: KEGG:R05222 xref: MetaCyc:COBINPGUANYLYLTRANS-RXN xref: RHEA:22712 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008821 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function alt_id: GO:0008844 def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.4 xref: MetaCyc:3.1.22.4-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008822 name: obsolete crotonobetaine/carnitine-CoA ligase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a bifunctional gene product. synonym: "crotonobetaine/carnitine-CoA ligase activity" EXACT [] is_obsolete: true consider: GO:0051108 consider: GO:0051109 [Term] id: GO:0008823 name: cupric reductase activity namespace: molecular_function def: "Catalysis of the reaction: Cu+ + NAD+ + H+ = Cu2+ + NADH." [PMID:10510271] xref: EC:1.16.1 xref: MetaCyc:R170-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0008824 name: cyanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyanate + H2O = carbamate." [EC:4.2.1.104] comment: Note that this function was formerly EC:4.3.99.1. synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanase activity" EXACT [] synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate lyase activity" EXACT [] xref: EC:4.2.1.104 xref: MetaCyc:R524-RXN xref: RHEA:24653 xref: UM-BBD_reactionID:r0608 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0008825 name: cyclopropane-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: MetaCyc:2.1.1.79-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008826 name: cysteine sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + sulfite." [MetaCyc:RXN0-279] synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1 xref: MetaCyc:RXN0-279 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0008827 name: cytochrome o ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2O; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] xref: EC:1.10.3 is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008828 name: dATP pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] xref: EC:3.6.1 xref: MetaCyc:RXN0-384 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008829 name: dCTP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] xref: EC:3.5.4.13 xref: MetaCyc:DCTP-DEAM-RXN xref: reactome:R-HSA-180632 "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand" xref: RHEA:22680 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008830 name: dTDP-4-dehydrorhamnose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-alpha-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13, RHEA:16969] synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] xref: EC:5.1.3.13 xref: KEGG:R06514 xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN xref: RHEA:16969 is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008831 name: dTDP-4-dehydrorhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP(+) = dTDP-4-dehydro-6-deoxy-L-mannose + H(+) + NADPH." [EC:1.1.1.133, RHEA:21796] synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] xref: EC:1.1.1.133 xref: KEGG:R02777 xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN xref: RHEA:21796 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008832 name: dGTPase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H(2)O = 2'-deoxyguanosine + 2 H(+) + triphosphate." [EC:3.1.5.1, RHEA:15193] synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] xref: EC:3.1.5.1 xref: KEGG:R01856 xref: MetaCyc:DGTPTRIPHYDRO-RXN xref: RHEA:15193 is_a: GO:0016793 ! triphosphoric monoester hydrolase activity [Term] id: GO:0008833 name: deoxyribonuclease IV (phage-T4-induced) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "endonuclease II" RELATED [EC:3.1.21.2] synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] xref: EC:3.1.21.2 xref: MetaCyc:3.1.21.2-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008834 name: di-trans,poly-cis-decaprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl diphosphate synthase activity" EXACT [] synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] xref: EC:2.5.1.31 xref: MetaCyc:RXN-8999 xref: RHEA:27551 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008835 name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity namespace: molecular_function alt_id: GO:0008485 def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H(2)O + H(+) = 5-amino-6-(5-phosphoribosylamino)uracil + NH(4)(+)." [EC:3.5.4.26, RHEA:21868] synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] xref: EC:3.5.4.26 xref: KEGG:R03459 xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN xref: RHEA:21868 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008836 name: diaminopimelate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminopimelate + H(+) = L-lysine + CO(2)." [EC:4.1.1.20, RHEA:15101] synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] xref: EC:4.1.1.20 xref: KEGG:R00451 xref: MetaCyc:DIAMINOPIMDECARB-RXN xref: RHEA:15101 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008837 name: diaminopimelate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminopimelate = meso-2,6-diaminopimelate." [EC:5.1.1.7, RHEA:15393] synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] xref: EC:5.1.1.7 xref: KEGG:R02735 xref: MetaCyc:DIAMINOPIMEPIM-RXN xref: RHEA:15393 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008838 name: diaminopropionate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] xref: EC:4.3.1.15 xref: MetaCyc:4.3.1.15-RXN xref: RHEA:22084 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008839 name: 4-hydroxy-tetrahydrodipicolinate reductase namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H + H+." [EC:1.17.1.8] synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] synonym: "dihydrodipicolinate reductase activity" EXACT [] synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] xref: EC:1.17.1.8 xref: MetaCyc:DIHYDROPICRED-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008840 name: 4-hydroxy-tetrahydrodipicolinate synthase namespace: molecular_function def: "Catalysis of the reaction: pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O." [EC:4.3.3.7, RHEA:14845] synonym: "DHDPS activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinate synthase activity" EXACT [] synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] xref: EC:4.3.3.7 xref: KEGG:R02292 xref: MetaCyc:DIHYDRODIPICSYN-RXN xref: RHEA:14845 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008841 name: dihydrofolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] synonym: "DHFS activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] synonym: "FHFS activity" EXACT [EC:6.3.2.12] synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] xref: EC:6.3.2.12 xref: MetaCyc:DIHYDROFOLATESYNTH-RXN xref: RHEA:23584 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008842 name: diphosphate-purine nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] xref: EC:2.7.1.143 xref: MetaCyc:2.7.1.143-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0008843 name: endochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal (1->4)-beta linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, endochitinases cleave randomly within the chitin chain." [EC:3.2.1.-, GOC:bf, GOC:kah, GOC:pde, PMID:11468293] is_a: GO:0004568 ! chitinase activity [Term] id: GO:0008845 name: obsolete endonuclease VIII activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806] comment: This term was made obsolete because it represents a gene product. synonym: "endonuclease VIII activity" EXACT [] is_obsolete: true consider: GO:0000703 consider: GO:0003684 consider: GO:0003906 consider: GO:0004519 consider: GO:0008081 consider: GO:0019104 [Term] id: GO:0008846 name: obsolete endopeptidase La activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] comment: This term was made obsolete because it represents a gene product. synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] synonym: "endopeptidase La activity" EXACT [] synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] synonym: "gene lon proteins" RELATED [EC:3.4.21.53] synonym: "lon proteinase" NARROW [EC:3.4.21.53] synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] xref: EC:3.4.21.53 xref: MetaCyc:3.4.21.53-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008847 name: Enterobacter ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6] synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6] synonym: "Enterobacter RNase activity" EXACT [] xref: EC:3.1.27.6 xref: MetaCyc:3.1.27.6-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008848 name: obsolete enterobactin synthetase namespace: molecular_function alt_id: GO:0008850 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a process rather than a function. synonym: "enterobactin synthetase" EXACT [] synonym: "enterochelin synthetase activity" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_obsolete: true replaced_by: GO:0009239 [Term] id: GO:0008849 name: enterochelin esterase activity namespace: molecular_function def: "Catalysis of the reaction: enterobactin + 3 H2O = 3 N-23-dihydroxybenzoyl-L-serine + 3 H+." [MetaCyc:RXN0-1661, PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] xref: MetaCyc:RXN0-1661 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008851 name: ethanolamine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] xref: EC:4.3.1.7 xref: MetaCyc:ETHAMLY-RXN xref: RHEA:15313 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008852 name: exodeoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] xref: EC:3.1.11.1 xref: MetaCyc:3.1.11.1-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008853 name: exodeoxyribonuclease III activity namespace: molecular_function def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] xref: EC:3.1.11.2 xref: MetaCyc:3.1.11.2-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008854 name: exodeoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] xref: EC:3.1.11.5 xref: MetaCyc:3.1.11.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008855 name: exodeoxyribonuclease VII activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] xref: EC:3.1.11.6 xref: MetaCyc:3.1.11.6-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008856 name: exodeoxyribonuclease X activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] xref: EC:3.1.11 xref: MetaCyc:3.1.22.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008859 name: exoribonuclease II activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] synonym: "RNase II" RELATED [EC:3.1.13.1] synonym: "RNase II activity" EXACT [] xref: EC:3.1.13.1 xref: MetaCyc:3.1.13.1-RXN is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008860 name: ferredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin-NAD reductase activity" EXACT [] synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008861 name: formate C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "PFL" EXACT [] synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] synonym: "pyruvate formate:lyase activity" EXACT [] synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] xref: EC:2.3.1.54 xref: MetaCyc:PYRUVFORMLY-RXN xref: RHEA:11844 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008863 name: formate dehydrogenase (NAD+) activity namespace: molecular_function alt_id: GO:0018476 def: "Catalysis of the reaction: formate + NAD(+) = CO(2) + NADH." [EC:1.2.1.2, RHEA:15985] synonym: "FDH I" RELATED [EC:1.2.1.2] synonym: "FDH II" RELATED [EC:1.2.1.2] synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2] synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2] synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2] synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2] synonym: "N-FDH" RELATED [EC:1.2.1.2] synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2] xref: EC:1.2.1.2 xref: KEGG:R00519 xref: MetaCyc:1.2.1.2-RXN xref: MetaCyc:FORMATEDEHYDROG-RXN xref: RHEA:15985 xref: UM-BBD_reactionID:r0103 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008864 name: formyltetrahydrofolate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O = (6S)-5,6,7,8-tetrahydrofolate + formate + H(+)." [EC:3.5.1.10, RHEA:19833] synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] xref: EC:3.5.1.10 xref: KEGG:R00944 xref: MetaCyc:FORMYLTHFDEFORMYL-RXN xref: RHEA:19833 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008865 name: fructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] xref: EC:2.7.1.4 xref: MetaCyc:FRUCTOKINASE-RXN xref: RHEA:16125 is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0008866 name: fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD(+) = D-fructuronate + H(+) + NADH." [EC:1.1.1.57, RHEA:15729] synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] xref: EC:1.1.1.57 xref: KEGG:R02454 xref: MetaCyc:MANNONOXIDOREDUCT-RXN xref: RHEA:15729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008867 name: galactarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: galactarate = 5-dehydro-4-deoxy-D-glucarate + H(2)O." [EC:4.2.1.42, RHEA:16005] synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] xref: EC:4.2.1.42 xref: KEGG:R05608 xref: MetaCyc:GALACTARDEHYDRA-RXN xref: RHEA:16005 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008868 name: galactitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = D-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] xref: EC:1.1.1.251 xref: MetaCyc:1.1.1.251-RXN xref: RHEA:15137 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008869 name: galactonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H(2)O." [EC:4.2.1.6, RHEA:18649] synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] xref: EC:4.2.1.6 xref: KEGG:R03033 xref: MetaCyc:GALACTONDEHYDRAT-RXN xref: RHEA:18649 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008870 name: galactoside O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: MetaCyc:GALACTOACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008871 name: aminoglycoside 2''-nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] xref: EC:2.7.7.46 xref: MetaCyc:2.7.7.46-RXN is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0008872 name: glucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] xref: EC:4.2.1.40 xref: MetaCyc:GLUCARDEHYDRA-RXN xref: RHEA:14573 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008873 name: gluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] xref: EC:1.1.1.215 xref: MetaCyc:1.1.1.215-RXN xref: RHEA:16653 is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008874 name: gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] xref: EC:1.1.1.69 xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008875 name: gluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008876 name: quinoprotein glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] comment: Note that this was EC:1.1.99.17. synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] xref: EC:1.1.5.2 xref: MetaCyc:GLUCDEHYDROG-RXN xref: RHEA:22152 is_a: GO:0004344 ! glucose dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008877 name: glucose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] xref: EC:3.1.3.10 xref: KEGG:R00304 xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN xref: RHEA:19933 is_a: GO:0050308 ! sugar-phosphatase activity [Term] id: GO:0008878 name: glucose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + ATP = ADP-glucose + diphosphate." [EC:2.7.7.27, RHEA:12120] synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADGase activity" EXACT [] synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ADPG pyrophosphorylase activity" EXACT [] synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] xref: EC:2.7.7.27 xref: KEGG:R00948 xref: MetaCyc:GLUC1PADENYLTRANS-RXN xref: RHEA:12120 is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008879 name: glucose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose." [EC:2.7.7.24, RHEA:15225] synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] xref: EC:2.7.7.24 xref: KEGG:R02328 xref: MetaCyc:DTDPGLUCOSEPP-RXN xref: RHEA:15225 is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0008880 name: glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] xref: EC:5.3.1.12 xref: MetaCyc:GLUCUROISOM-RXN xref: RHEA:13049 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008881 name: glutamate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3, RHEA:12813] xref: EC:5.1.1.3 xref: KEGG:R00260 xref: MetaCyc:GLUTRACE-RXN xref: RHEA:12813 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008882 name: [glutamate-ammonia-ligase] adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]." [EC:2.7.7.42] synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: MetaCyc:GSADENYLATION-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008883 name: glutamyl-tRNA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-4-amino-5-oxopentanoate + NADP(+) + tRNA(Glu) = L-glutamyl-tRNA(Glu) + H(+) + NADPH." [EC:1.2.1.70, RHEA:12344] synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] xref: EC:1.2.1.70 xref: KEGG:R04109 xref: MetaCyc:GLUTRNAREDUCT-RXN xref: RHEA:12344 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0008884 name: glutathionylspermidine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] xref: EC:3.5.1.78 xref: MetaCyc:GSPAMID-RXN xref: RHEA:17173 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008885 name: glutathionylspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] xref: EC:6.3.1.8 xref: MetaCyc:GSPSYN-RXN xref: RHEA:21272 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008886 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) (non-phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + H(2)O + NADP(+) = 3-phospho-D-glycerate + 2 H(+) + NADPH." [EC:1.2.1.9, RHEA:14669] synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] xref: EC:1.2.1.9 xref: KEGG:R01058 xref: MetaCyc:1.2.1.9-RXN xref: RHEA:14669 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008887 name: glycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + ATP = 3-phospho-D-glycerate + ADP + 2 H(+)." [EC:2.7.1.31, RHEA:23516] synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] synonym: "GK" RELATED [EC:2.7.1.31] synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] xref: EC:2.7.1.31 xref: KEGG:R01514 xref: MetaCyc:GLY3KIN-RXN xref: reactome:R-HSA-6799495 "GLYCTK phosphorylates DGA to 3PDGA" xref: RHEA:23516 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008888 name: glycerol dehydrogenase [NAD+] activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD(+) = glycerone + H(+) + NADH." [EC:1.1.1.6, RHEA:13769] synonym: "glycerol dehydrogenase activity" BROAD [] synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: KEGG:R01034 xref: MetaCyc:GLYCDEH-RXN xref: RHEA:13769 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008889 name: glycerophosphodiester phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] synonym: "gene hpd protein" RELATED [EC:3.1.4.46] synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] xref: EC:3.1.4.46 xref: MetaCyc:GLYCPDIESTER-RXN xref: reactome:R-HSA-1483107 "GPETA is hydrolyzed to ETA and G3P by GPCPD1" xref: reactome:R-HSA-1483116 "GPCho is hydrolyzed to Cho and G3P by GPCPD1" is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008890 name: glycine C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glycine = L-2-amino-3-oxobutanoate + CoA + H(+)." [EC:2.3.1.29, RHEA:20736] synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] xref: EC:2.3.1.29 xref: KEGG:R00371 xref: MetaCyc:AKBLIG-RXN xref: RHEA:20736 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008891 name: glycolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + hydrogen peroxide." [EC:1.1.3.15] xref: MetaCyc:RXN-969 xref: reactome:R-HSA-389842 "HAO1 tetramer oxidizes glycolate to glyoxylate" is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0008892 name: guanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] synonym: "GAH activity" EXACT [EC:3.5.4.3] synonym: "guanase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] xref: EC:3.5.4.3 xref: MetaCyc:GUANINE-DEAMINASE-RXN xref: reactome:R-HSA-74255 "Guanine + H2O => Xanthine + NH4+" xref: RHEA:14665 is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008893 name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] xref: EC:3.1.7.2 xref: MetaCyc:PPGPPSYN-RXN xref: RHEA:14253 is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0008894 name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] xref: EC:3.6.1.40 xref: MetaCyc:PPPGPPHYDRO-RXN xref: RHEA:13073 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008897 name: holo-[acyl-carrier-protein] synthase activity namespace: molecular_function alt_id: GO:0008958 def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] synonym: "AcpS" RELATED [EC:2.7.8.7] synonym: "ACPS activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] synonym: "holosynthase activity" RELATED [EC:2.7.8.7] synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] synonym: "phosphopantetheinyltransferase activity" EXACT [] synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: MetaCyc:HOLO-ACP-SYNTH-RXN xref: reactome:R-HSA-199202 "Phosphopantetheine conjugation of the ACP domain of FAS" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008898 name: S-adenosylmethionine-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10, GOC:BHF, GOC:dph] synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine methyltransferase activity" RELATED [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" RELATED [EC:2.1.1.10] synonym: "L-homocysteine S-methyltransferase activity" RELATED [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN xref: RHEA:21820 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008899 name: homoserine O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + succinyl-CoA = O-succinyl-L-homoserine + CoA." [EC:2.3.1.46, RHEA:22008] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] xref: EC:2.3.1.46 xref: KEGG:R01777 xref: MetaCyc:HOMSUCTRAN-RXN xref: RHEA:22008 is_a: GO:0016750 ! O-succinyltransferase activity [Term] id: GO:0008900 name: potassium:proton exchanging ATPase activity namespace: molecular_function alt_id: GO:0005390 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10] synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10] synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10] synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10] synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium-exchanging ATPase activity" EXACT [] synonym: "proton pump activity" BROAD [EC:3.6.3.10] xref: EC:3.6.3.10 xref: reactome:R-HSA-937311 "ATP4A/12A:ATP4B exchanges K+ for H+" xref: RHEA:22044 is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015078 ! proton transmembrane transporter activity [Term] id: GO:0008901 name: ferredoxin hydrogenase activity namespace: molecular_function alt_id: GO:0016948 alt_id: GO:0016949 alt_id: GO:0016950 alt_id: GO:0016951 def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. synonym: "[Fe] hydrogenase activity" EXACT [] synonym: "[Fe] hydrogenase gamma" RELATED [] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H2 oxidizing hydrogenase" BROAD [] synonym: "H2 producing hydrogenase" BROAD [] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] synonym: "hydrogenase activity" BROAD [] synonym: "hydrogenase I" RELATED [] synonym: "hydrogenase II" RELATED [] synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] synonym: "iron hydrogenase activity" NARROW [] synonym: "iron-only hydrogenase activity" NARROW [] synonym: "Ni-Fe hydrogenase activity" NARROW [] synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] synonym: "nickel hydrogenase activity" NARROW [] synonym: "nickel-iron hydrogenase activity" NARROW [] synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: MetaCyc:HYDROG-RXN xref: UM-BBD_enzymeID:e0418 is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor [Term] id: GO:0008902 name: hydroxymethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-5-hydroxymethyl-2-methylpyrimidine + ATP = 4-amino-2-methyl-5-phosphomethylpyrimidine + ADP + 2 H(+)." [EC:2.7.1.49, RHEA:23096] synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] xref: EC:2.7.1.49 xref: KEGG:R03471 xref: MetaCyc:OHMETPYRKIN-RXN xref: RHEA:23096 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008903 name: hydroxypyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22, RHEA:11952] synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] xref: EC:5.3.1.22 xref: KEGG:R01394 xref: MetaCyc:RXN0-305 xref: RHEA:11952 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008904 name: hygromycin-B 7''-O-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + hygromycin B = 7''-O-phosphohygromycin B + ADP + 2 H(+)." [EC:2.7.1.119, RHEA:23388] synonym: "APH(7'') activity" RELATED [EC:2.7.1.119] synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" EXACT [EC:2.7.1.119] synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] synonym: "hygromycin B kinase activity" BROAD [] synonym: "hygromycin B phosphotransferase activity" BROAD [EC:2.7.1.119] synonym: "hygromycin-B kinase activity" BROAD [] xref: EC:2.7.1.119 xref: KEGG:R03770 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN xref: RHEA:23388 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008905 name: mannose-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] xref: EC:2.7.7 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008906 name: inosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] xref: EC:2.7.1.73 xref: MetaCyc:INOSINEKIN-RXN xref: RHEA:21140 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008907 name: integrase activity namespace: molecular_function def: "Catalysis of the integration of one segment of DNA into another." [GOC:mah] subset: goslim_pir xref: reactome:R-HSA-164523 "Transesterification to connect viral DNA 3' ends to host DNA 5' ends" is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0008908 name: isochorismatase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + isochorismate = 2,3-dihydroxy-2,3-dihydrobenzoate + pyruvate." [EC:3.3.2.1, RHEA:11112] synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] xref: EC:3.3.2.1 xref: KEGG:R03037 xref: MetaCyc:ISOCHORMAT-RXN xref: RHEA:11112 is_a: GO:0004463 ! leukotriene-A4 hydrolase activity [Term] id: GO:0008909 name: isochorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.4.2, RHEA:18985] comment: Note that this function was formerly EC:5.4.99.6. synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] synonym: "isochorismate mutase activity" EXACT [] synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] xref: EC:5.4.4.2 xref: KEGG:R01717 xref: MetaCyc:ISOCHORSYN-RXN xref: RHEA:18985 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0008910 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + 2 H(+) + kanamycin 3'-phosphate." [EC:2.7.1.95, RHEA:24256] synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "APH(3') activity" EXACT [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] xref: EC:2.7.1.95 xref: KEGG:R01888 xref: MetaCyc:KANAMYCIN-KINASE-RXN xref: RHEA:24256 is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008911 name: lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] xref: EC:1.2.1.22 xref: MetaCyc:LACTALDDEHYDROG-RXN xref: RHEA:14277 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0008912 name: lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: propane-1,2-diol + NAD+ = lactaldehyde + NADH + H+." [EC:1.1.1.77] synonym: "(R)- or (S)-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol oxidoreductase activity" BROAD [EC:1.1.1.77] synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] xref: EC:1.1.1.77 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008913 name: lauroyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732] synonym: "lauroyl transferase activity" EXACT [] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008914 name: leucyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: MetaCyc:LEUCYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0008915 name: lipid-A-disaccharide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + UDP-2,3-bis(3-hydroxytetradecanoyl)-D-glucosamine = 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + H(+) + UDP." [EC:2.4.1.182, RHEA:22668] synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] xref: EC:2.4.1.182 xref: KEGG:R04606 xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN xref: RHEA:22668 is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008917 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56, GOC:mr, KEGG:00540] synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] xref: EC:2.4.1.56 xref: MetaCyc:2.4.1.56-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008918 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44, GOC:mr, KEGG:00540] synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] xref: EC:2.4.1.44 xref: MetaCyc:2.4.1.44-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008919 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58, GOC:mr, KEGG:00540] synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] xref: EC:2.4.1.58 xref: MetaCyc:2.4.1.58-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008920 name: lipopolysaccharide heptosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a lipopolysaccharide + ADP-L-glycero-beta-D-manno-heptose = a heptosylated lipopolysaccharide + ADP + H+." [MetaCyc:RXN0-5061, MetaCyc:RXN0-5122, MetaCyc:RXN0-5127] synonym: "LPS heptosyltransferase activity" EXACT [] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008921 name: lipopolysaccharide-1,6-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008922 name: long-chain fatty acid [acyl-carrier-protein] ligase activity namespace: molecular_function alt_id: GO:0010300 def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]. A long-chain fatty acid is fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:6.2.1.20] synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-ACP synthetase activity" EXACT [] synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: KEGG:R07325 xref: MetaCyc:ACYLACPSYNTH-RXN is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0008923 name: lysine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine + H(+) = cadaverine + CO(2)." [EC:4.1.1.18, RHEA:22352] synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] xref: EC:4.1.1.18 xref: KEGG:R00462 xref: MetaCyc:LYSDECARBOX-RXN xref: MetaCyc:PWY0-461 xref: RHEA:22352 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008924 name: malate dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + a quinone = oxaloacetate + a quinol." [MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN] synonym: "(S)-malate:(quinone) oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "(S)-malate:quinone oxidoreductase activity" EXACT [EC:1.1.5.4] synonym: "FAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.5.4] synonym: "MQO activity" BROAD [EC:1.1.5.4] xref: EC:1.1.5.4 xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN xref: RHEA:22556 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008925 name: maltose O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] xref: EC:2.3.1.79 xref: MetaCyc:MALTACETYLTRAN-RXN xref: RHEA:10456 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008926 name: mannitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] xref: EC:1.1.1.17 xref: MetaCyc:MANNPDEHYDROG-RXN xref: RHEA:19661 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008927 name: mannonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H(2)O." [EC:4.2.1.8, RHEA:20097] synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] xref: EC:4.2.1.8 xref: KEGG:R05606 xref: MetaCyc:MANNONDEHYDRAT-RXN xref: RHEA:20097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008928 name: mannose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-mannose 1-phosphate + GDP + H(+) = GDP-alpha-D-mannose + phosphate." [EC:2.7.7.22, RHEA:12905] synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] xref: EC:2.7.7.22 xref: KEGG:R00883 xref: MetaCyc:MANNPGUANYLTRANGDP-RXN xref: RHEA:12905 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0008929 name: methylglyoxal synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3, RHEA:17937] synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] xref: EC:4.2.3.3 xref: KEGG:R01016 xref: MetaCyc:METHGLYSYN-RXN xref: RHEA:17937 is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0008930 name: methylthioadenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] xref: EC:3.2.2.16 xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN xref: RHEA:13617 is_a: GO:0008477 ! purine nucleosidase activity [Term] id: GO:0008931 name: obsolete murein DD-endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "murein DD-endopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008932 name: lytic endotransglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] synonym: "murein lytic endotransglycosylase E activity" NARROW [] xref: EC:2.4.99 is_a: GO:0008933 ! lytic transglycosylase activity [Term] id: GO:0008933 name: lytic transglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-(1->4) glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424, PMID:22748813] synonym: "murein transglycosylase B activity" NARROW [] synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups is_a: GO:0061783 ! peptidoglycan muralytic activity [Term] id: GO:0008934 name: inositol monophosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol-1(or 4)-monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" BROAD [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:RXN0-5408 xref: reactome:R-HSA-1855154 "I1P is dephosphorylated to Ins by IMPA1/2 in the cytosol" xref: RHEA:27670 is_a: GO:0052834 ! inositol monophosphate phosphatase activity [Term] id: GO:0008935 name: 1,4-dihydroxy-2-naphthoyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(2-carboxyphenyl)-4-oxobutanoyl-CoA = 1,4-dihydroxy-2-napthoyl-CoA + H2O." [EC:4.1.3.36] synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] synonym: "O-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase activity" RELATED [KEGG:R04150] xref: EC:4.1.3.36 xref: KEGG:R04150 xref: MetaCyc:NAPHTHOATE-SYN-RXN xref: RHEA:15525 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008936 name: nicotinamidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] synonym: "NAMase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] synonym: "YNDase activity" EXACT [EC:3.5.1.19] xref: EC:3.5.1.19 xref: MetaCyc:NICOTINAMID-RXN xref: RHEA:14545 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008937 name: ferredoxin-NAD(P) reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] synonym: "ferredoxin reductase activity" BROAD [] xref: EC:1.18.1 is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008938 name: nicotinate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + nicotinate = N-methylnicotinate + S-adenosyl-L-homocysteine." [EC:2.1.1.7, RHEA:20241] synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] xref: EC:2.1.1.7 xref: KEGG:R01721 xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN xref: RHEA:20241 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008939 name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dimethylbenzimidazole + nicotinate D-ribonucleotide = alpha-ribazole 5'-phosphate + H(+) + nicotinate." [EC:2.4.2.21, RHEA:11196] synonym: "CobT" RELATED [EC:2.4.2.21] synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] xref: EC:2.4.2.21 xref: KEGG:R04148 xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN xref: RHEA:11196 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008940 name: nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + acceptor = nitrate + reduced acceptor." [EC:1.7.99.4] synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] xref: EC:1.7.99.4 xref: MetaCyc:NITRATREDUCT-RXN xref: RHEA:21068 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0008941 name: nitric oxide dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 nitrate + NADP+." [EC:1.14.12.17] synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] synonym: "NOD activity" EXACT [EC:1.14.12.17] xref: EC:1.14.12.17 xref: MetaCyc:R621-RXN xref: reactome:R-HSA-1222723 "Nitric oxide is oxidized to nitrate" xref: reactome:R-HSA-5340226 "CYGB dioxygenates NO" is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008942 name: nitrite reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = nitrite + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] comment: Note that this function was formerly EC:1.6.6.4. synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] xref: EC:1.7.1.4 xref: KEGG:R00787 xref: KEGG:R00789 xref: MetaCyc:NITRITREDUCT-RXN xref: RHEA:24628 xref: RHEA:24632 is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor is_a: GO:0098809 ! nitrite reductase activity [Term] id: GO:0008943 name: obsolete glyceraldehyde-3-phosphate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions: glyceraldehyde 3-phosphate + phosphate + NAD(P)+ = 3-phospho-D-glyceroyl-phosphate + NAD(P)H + H+, and glyceraldehyde 3-phosphate + H2O + NAD(P)+ = 3-phospho-D-glycerate + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] comment: This term was made obsolete because it is a grouping term based on similar names. synonym: "glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] is_obsolete: true consider: GO:0004365 consider: GO:0008886 consider: GO:0043878 consider: GO:0047100 [Term] id: GO:0008944 name: obsolete oligopeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] comment: This term was made obsolete because it represents a gene product. synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] synonym: "oligopeptidase A activity" EXACT [] xref: EC:3.4.24.70 xref: MetaCyc:3.4.24.70-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008945 name: obsolete oligopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] comment: This term was made obsolete because it represents a gene product. synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "oligopeptidase B activity" EXACT [] synonym: "protease II activity" EXACT [EC:3.4.21.83] xref: EC:3.4.21.83 xref: MetaCyc:3.4.21.83-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008946 name: oligonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. xref: EC:3.1.13.3 xref: MetaCyc:3.1.13.3-RXN is_a: GO:0004518 ! nuclease activity [Term] id: GO:0008947 name: obsolete omptin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] comment: This term was made obsolete because it represents a gene product. synonym: "omptin activity" EXACT [] xref: EC:3.4.21.87 xref: MetaCyc:3.4.21.87-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008948 name: oxaloacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:1.1.1.38, EC:1.1.1.40, EC:4.1.1.3] synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3] xref: EC:1.1.1.38 xref: EC:1.1.1.40 xref: EC:4.1.1.3 xref: KEGG:R00217 xref: MetaCyc:OXALODECARB-RXN xref: reactome:R-HSA-9012016 "FAHD1:Zn2+ dimer hydrolyses OA to PYR" xref: RHEA:15641 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008949 name: oxalyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + oxalyl-CoA = CO(2) + formyl-CoA." [EC:4.1.1.8, RHEA:19333] synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] xref: EC:4.1.1.8 xref: KEGG:R01908 xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN xref: RHEA:19333 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008950 name: obsolete p-aminobenzoate synthetase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. synonym: "p-aminobenzoate synthetase" EXACT [] is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008951 name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: a palmitoleoyl-[acyl-carrier protein] + alpha-KDO-(2->4)-alpha-KDO-(2->6)-lipid IVA = KDO2-(palmitoleoyl)-lipid IVA + a holo-[acyl-carrier protein]." [MetaCyc:PALMITOTRANS-RXN] synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: EC:2.3.1 xref: MetaCyc:PALMITOTRANS-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008953 name: penicillin amidase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "novozym 217" RELATED [EC:3.5.1.11] synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] synonym: "semacylase activity" EXACT [EC:3.5.1.11] xref: EC:3.5.1.11 xref: MetaCyc:PENICILLIN-AMIDASE-RXN xref: RHEA:18693 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008954 name: obsolete peptidoglycan synthetase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was not defined, is ambiguous, and has been used to annotate gene products with very different activities. synonym: "peptidoglycan synthetase activity" EXACT [] is_obsolete: true consider: GO:0008955 consider: GO:0071972 [Term] id: GO:0008955 name: peptidoglycan glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: MetaCyc:RXN0-5405 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008956 name: obsolete peptidyl-dipeptidase Dcp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] comment: This term was made obsolete because it represents a gene product. synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] synonym: "peptidyl-dipeptidase Dcp activity" EXACT [] xref: EC:3.4.15.5 xref: MetaCyc:3.4.15.5-RXN is_obsolete: true consider: GO:0008235 consider: GO:0008241 [Term] id: GO:0008957 name: phenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] xref: EC:1.2.1.39 xref: MetaCyc:PHENDEHYD-RXN xref: RHEA:21392 xref: UM-BBD_reactionID:r0035 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0008959 name: phosphate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] synonym: "PTA" RELATED [EC:2.3.1.8] xref: EC:2.3.1.8 xref: MetaCyc:PHOSACETYLTRANS-RXN xref: RHEA:19521 is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0008960 name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] xref: EC:2.7.8.20 xref: MetaCyc:PGLYCEROLTRANSI-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008961 name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity namespace: molecular_function def: "Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein." [PMID:8051048] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0008962 name: phosphatidylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] xref: EC:3.1.3.27 xref: MetaCyc:PGPPHOSPHA-RXN xref: reactome:R-HSA-1483197 "PTPMT1 dephosphorylates PGP to PG" xref: RHEA:16725 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: goslim_chembl synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008964 name: phosphoenolpyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + oxaloacetate = phosphoenolpyruvate + HCO3-." [EC:4.1.1.31] synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] synonym: "PEPC" RELATED [EC:4.1.1.31] synonym: "PEPCase activity" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] xref: EC:4.1.1.31 xref: KEGG:R00345 xref: MetaCyc:PEPCARBOX-RXN xref: RHEA:28370 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0008965 name: phosphoenolpyruvate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: MetaCyc:2.7.3.9-RXN is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0008966 name: phosphoglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10, RHEA:23424] synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] xref: EC:5.4.2.10 xref: KEGG:R02060 xref: MetaCyc:5.4.2.10-RXN xref: RHEA:23424 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008967 name: phosphoglycolate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycolate + H(2)O = glycolate + phosphate." [EC:3.1.3.18, RHEA:14369] synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] xref: EC:3.1.3.18 xref: KEGG:R01334 xref: MetaCyc:GPH-RXN xref: RHEA:14369 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008968 name: D-sedoheptulose 7-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] synonym: "phosphoheptose isomerase activity" EXACT [] xref: MetaCyc:RXN0-4301 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008970 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: goslim_chembl synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN xref: reactome:R-HSA-1482827 "PC is hydrolyzed to 2-acyl LPC by PLA2G4C" xref: reactome:R-HSA-1482828 "PE is hydrolyzed to 2-acyl LPE by PLA2[4]" xref: reactome:R-HSA-1482847 "PG is hydrolysed to 2-acyl LPG by PLA2G4B (IM)" xref: reactome:R-HSA-1482862 "PC is hydrolysed to 2-acyl LPC by PLA2[7]" xref: reactome:R-HSA-1482892 "PE is hydrolyzed to 2-acyl LPE by PLA2G4C" xref: reactome:R-HSA-1482920 "PG is hydrolyzed to 2-acyl LPG by PLA2[14]" xref: reactome:R-HSA-1482932 "PI is hydrolyzed to 2-acyl LPI by PLA2[13]" xref: reactome:R-HSA-5694485 "ABHD3 hydrolyses LPC(14:0) to 1AGPC" is_a: GO:0004620 ! phospholipase activity is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0008972 name: phosphomethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] xref: EC:2.7.4.7 xref: MetaCyc:PYRIMSYN3-RXN xref: RHEA:19893 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008973 name: phosphopentomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] xref: EC:5.4.2.7 xref: MetaCyc:PPENTOMUT-RXN xref: reactome:R-HSA-6787329 "PGM2:Mg2+ isomerises R1P to R5P" xref: reactome:R-HSA-8982667 "PGM2:Mg2+ isomerises dR1P to dR5P" xref: RHEA:18793 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008974 name: phosphoribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate + ATP = D-ribulose 1,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.19, RHEA:19365] synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] synonym: "PKK" RELATED [EC:2.7.1.19] synonym: "PRK" RELATED [EC:2.7.1.19] synonym: "PRuK" RELATED [EC:2.7.1.19] synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] xref: EC:2.7.1.19 xref: KEGG:R01523 xref: MetaCyc:PHOSPHORIBULOKINASE-RXN xref: RHEA:19365 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008975 name: obsolete pitrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] comment: This term was made obsolete because it represents a gene product. synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] synonym: "pitrilysin activity" EXACT [] synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] xref: EC:3.4.24.55 xref: MetaCyc:3.4.24.55-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008976 name: polyphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "polyphosphate polymerase activity" EXACT [GOC:curators] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008977 name: prephenate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + prephenate = (4-hydroxyphenyl)pyruvate + CO(2) + NADH." [EC:1.3.1.12, RHEA:13869] synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] xref: EC:1.3.1.12 xref: KEGG:R01728 xref: MetaCyc:PREPHENATEDEHYDROG-RXN xref: RHEA:13869 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008978 name: obsolete prepilin peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] comment: This term was made obsolete because it represents a gene product. synonym: "prepilin peptidase activity" EXACT [] xref: EC:3.4.23.43 xref: MetaCyc:3.4.23.43-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0008979 name: prophage integrase activity namespace: molecular_function def: "Catalysis of the integration of prophage DNA into a target DNA molecule, usually a bacterial chromosome, via a sequence-specific recombination event which involves the formation of an intasome, a DNA-protein-complex designed for site-specific recombination of the phage and host DNA." [GOC:jl] synonym: "integrase activity involved in establishment of integrated proviral latency" EXACT [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity [Term] id: GO:0008980 name: propionate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15] synonym: "ATP:propanoate phosphotransferase activity" EXACT [] synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008981 name: obsolete protease IV activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "protease IV activity" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008982 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity namespace: molecular_function alt_id: GO:0015455 alt_id: GO:0015456 def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] synonym: "gene glC proteins" RELATED [EC:2.7.1.69] synonym: "group translocator activity" RELATED [EC:2.7.1.69] synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphotransfer-driven group translocator" EXACT [] synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "PTS permease activity" EXACT [EC:2.7.1.69] synonym: "PTS transporter" RELATED [EC:2.7.1.69] synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] xref: EC:2.7.1.69 xref: MetaCyc:2.7.1.69-RXN is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0008983 name: protein-glutamate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein methylase II" RELATED [EC:2.1.1.80] synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] xref: EC:2.1.1.80 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0008984 name: protein-glutamate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] xref: EC:3.1.1.61 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0008985 name: obsolete pyruvate dehydrogenase (cytochrome) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] comment: This term was made obsolete because the EC activity it represents, EC:1.2.2.2, has been deleted. synonym: "pyruvate dehydrogenase (cytochrome) activity" EXACT [] synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" RELATED [EC:1.2.2.2] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" RELATED [EC:1.2.2.2] synonym: "pyruvic (cytochrome b1) dehydrogenase activity" RELATED [EC:1.2.2.2] is_obsolete: true replaced_by: GO:0052737 [Term] id: GO:0008986 name: pyruvate, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + pyruvate = AMP + 3 H(+) + phosphate + phosphoenolpyruvate." [EC:2.7.9.2, RHEA:11364] synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] synonym: "PEP synthase activity" EXACT [] synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] synonym: "water pyruvate dikinase activity" EXACT [] xref: EC:2.7.9.2 xref: KEGG:R00199 xref: MetaCyc:PEPSYNTH-RXN xref: RHEA:11364 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0008987 name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] xref: MetaCyc:QUINOLINATE-SYNTHA-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008988 name: rRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0008989 name: rRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51] synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] xref: EC:2.1.1.51 xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008990 name: rRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] xref: EC:2.1.1.52 xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008991 name: obsolete serine-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "serine-type signal peptidase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008992 name: obsolete repressor LexA activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] comment: This term was made obsolete because it represents a gene product. synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] synonym: "repressor LexA activity" EXACT [] xref: EC:3.4.21.88 xref: MetaCyc:3.4.21.88-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008993 name: rhamnulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "RhuK" RELATED [EC:2.7.1.5] xref: EC:2.7.1.5 xref: MetaCyc:RHAMNULOKIN-RXN xref: RHEA:20117 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008994 name: rhamnulose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] xref: EC:4.1.2.19 xref: MetaCyc:RHAMNULPALDOL-RXN xref: RHEA:19689 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008995 name: ribonuclease E activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] xref: MetaCyc:3.1.26.12-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008996 name: ribonuclease G activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008997 name: ribonuclease R activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] xref: EC:3.1.11 is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008998 name: ribonucleoside-triphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] xref: EC:1.17.4.2 xref: MetaCyc:1.17.4.2-RXN xref: RHEA:12701 is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0008999 name: ribosomal-protein-alanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: MetaCyc:2.3.1.128-RXN is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity [Term] id: GO:0009000 name: selenocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN xref: reactome:R-HSA-2408524 "Sec is reduced to H2Se by SCLY" xref: RHEA:11632 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0009001 name: serine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA." [EC:2.3.1.30, RHEA:24560] synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "SATase activity" EXACT [EC:2.3.1.30] synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] xref: EC:2.3.1.30 xref: KEGG:R00586 xref: MetaCyc:SERINE-O-ACETTRAN-RXN xref: RHEA:24560 is_a: GO:0016412 ! serine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0009002 name: serine-type D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] xref: EC:3.4.16.4 xref: MetaCyc:3.4.16.4-RXN is_a: GO:0004185 ! serine-type carboxypeptidase activity [Term] id: GO:0009003 name: obsolete signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "signal peptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0008233 [Term] id: GO:0009004 name: obsolete signal peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] comment: This term was made obsolete because it represents a gene product. synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "HOSP" RELATED [EC:3.4.21.89] synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] synonym: "leader peptidase I" RELATED [EC:3.4.21.89] synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "propeptidase activity" EXACT [EC:3.4.21.89] synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] synonym: "signal peptidase I activity" EXACT [] synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] xref: EC:3.4.21.89 xref: MetaCyc:3.4.21.89-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0009005 name: obsolete signal peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] comment: This term was made obsolete because it represents a gene product. synonym: "leader peptidase II" RELATED [EC:3.4.23.36] synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "signal peptidase II activity" EXACT [] synonym: "SPase II activity" EXACT [EC:3.4.23.36] xref: EC:3.4.23.36 xref: MetaCyc:3.4.23.36-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009006 name: obsolete siroheme synthase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents three different molecular functions. synonym: "sirohaem synthase activity" EXACT [] synonym: "siroheme synthase activity" EXACT [] is_obsolete: true consider: GO:0004851 consider: GO:0019354 consider: GO:0043115 consider: GO:0051266 [Term] id: GO:0009007 name: site-specific DNA-methyltransferase (adenine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] synonym: "DNA adenine methylase" BROAD [] synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] synonym: "modification methylase activity" RELATED [EC:2.1.1.72] synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: MetaCyc:2.1.1.72-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0009008 name: DNA-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732, PMID:7862522] synonym: "deoxyribonucleate methylase activity" EXACT [] synonym: "deoxyribonucleate methyltransferase activity" EXACT [] synonym: "deoxyribonucleic acid methylase activity" EXACT [] synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [] synonym: "deoxyribonucleic acid modification methylase activity" RELATED [] synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] xref: reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: reactome:R-HSA-5227490 "NoRC:HDAC:DNMT methylates cytosine of the rRNA genes" is_a: GO:0008168 ! methyltransferase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0009009 name: site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. subset: goslim_pir is_a: GO:0000150 ! recombinase activity [Term] id: GO:0009010 name: sorbitol-6-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] xref: EC:1.1.1.140 xref: MetaCyc:SORB6PDEHYDROG-RXN xref: RHEA:19837 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009011 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] xref: EC:2.4.1.21 xref: MetaCyc:GLYCOGENSYN-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0009012 name: aminoglycoside 3''-adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + streptomycin = 3''-adenylylstreptomycin + diphosphate + H(+)." [EC:2.7.7.47, RHEA:20245] synonym: "AAD (3'')" RELATED [EC:2.7.7.47] synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] xref: EC:2.7.7.47 xref: KEGG:R02226 xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN xref: RHEA:20245 is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0009013 name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] xref: EC:1.2.1.16 xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN xref: UM-BBD_reactionID:r0371 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0009014 name: succinyl-diaminopimelate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H(2)O = LL-2,6-diaminopimelate + succinate." [EC:3.5.1.18, RHEA:22608] synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] xref: EC:3.5.1.18 xref: KEGG:R02734 xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN xref: RHEA:22608 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009015 name: N-succinylarginine dihydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H(2)O + 2 H(+) = N(2)-succinyl-L-ornithine + CO(2) + 2 NH(4)(+)." [EC:3.5.3.23, RHEA:19533] synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] synonym: "arginine succinylhydrolase activity" EXACT [] synonym: "AruB" RELATED [] synonym: "AstB" RELATED [] synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] synonym: "N2-succinylarginine dihydrolase activity" EXACT [] synonym: "SADH" RELATED [] synonym: "succinylarginine dihydrolase activity" EXACT [] xref: EC:3.5.3.23 xref: KEGG:R04189 xref: MetaCyc:SUCCARGDIHYDRO-RXN xref: RHEA:19533 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0009016 name: succinyldiaminopimelate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + N-succinyl-LL-2,6-diaminopimelate = L-2-succinylamino-6-oxopimelate + L-glutamate." [EC:2.6.1.17, RHEA:11960] synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] xref: EC:2.6.1.17 xref: KEGG:R04475 xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN xref: RHEA:11960 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009017 name: succinylglutamate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate + H(2)O = L-glutamate + succinate." [EC:3.5.1.96, RHEA:15169] synonym: "AstE" RELATED [] synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] synonym: "SGDS" RELATED [] xref: EC:3.5.1.96 xref: KEGG:R00411 xref: MetaCyc:SUCCGLUDESUCC-RXN xref: RHEA:15169 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009018 name: sucrose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] xref: EC:2.4.1.7 xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN xref: RHEA:24048 is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0009019 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: EC:2.1.1 xref: reactome:R-HSA-6782859 "TRMT5 methylates guanosine yielding 1-methylguanosine at nucleotide 37 of tRNA(Phe)" xref: reactome:R-HSA-6786621 "TRMT10A methylates guanosine-9 in tRNA" xref: reactome:R-HSA-6787591 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) of mitochondrial RNase P methylates guanosine-9 in tRNA yielding 1-methylguanosine-9" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009020 name: tRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: MetaCyc:2.1.1.34-RXN xref: reactome:R-HSA-9024161 "FTSJ1 2'-O-methylates guanosine-34 in tRNA(Phe)" is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity is_a: GO:0106050 ! tRNA 2'-O-methyltransferase activity [Term] id: GO:0009022 name: tRNA nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0009023 name: obsolete tRNA sulfurtransferase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] synonym: "tRNA sulfurtransferase" EXACT [] synonym: "tRNA sulphurtransferase activity" EXACT [] is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0009024 name: tagatose-6-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] xref: EC:2.7.1.144 xref: MetaCyc:TAGAKIN-RXN xref: RHEA:12420 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009025 name: tagatose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose 1,6-diphosphate = D-glyceraldehyde 3-phosphate + glycerone phosphate." [EC:4.1.2.40, RHEA:22948] synonym: "AgaY" RELATED [] synonym: "AgaZ" RELATED [] synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] synonym: "KbaY" RELATED [] synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] xref: EC:4.1.2.40 xref: KEGG:R01069 xref: MetaCyc:TAGAALDOL-RXN xref: RHEA:22948 is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0009026 name: tagaturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate + NAD(+) = D-tagaturonate + H(+) + NADH." [EC:1.1.1.58, RHEA:17813] synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "TagUAR" RELATED [EC:1.1.1.58] xref: EC:1.1.1.58 xref: KEGG:R02555 xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN xref: RHEA:17813 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009027 name: tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009028 name: tartronate-semialdehyde synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glyoxylate + H(+) = 2-hydroxy-3-oxopropanoate + CO(2)." [EC:4.1.1.47, RHEA:10136] synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] xref: EC:4.1.1.47 xref: KEGG:R00013 xref: MetaCyc:GLYOCARBOLIG-RXN xref: RHEA:10136 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0009029 name: tetraacyldisaccharide 4'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(1->6)-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate + ATP = ADP + 2 H(+) + lipid IV(a)." [EC:2.7.1.130, RHEA:20700] synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] xref: EC:2.7.1.130 xref: KEGG:R04657 xref: MetaCyc:TETRAACYLDISACC4KIN-RXN xref: RHEA:20700 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009030 name: thiamine-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine phosphate = ADP + H(+) + thiamine diphosphate." [EC:2.7.4.16, RHEA:15913] synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin phosphate kinase activity" EXACT [GOC:curators] synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-phosphate kinase activity" EXACT [] synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] xref: EC:2.7.4.16 xref: KEGG:R00617 xref: MetaCyc:THI-P-KIN-RXN xref: RHEA:15913 is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0009032 name: thymidine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "gliostatins" RELATED [EC:2.4.2.4] synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] xref: EC:2.4.2.4 xref: MetaCyc:THYM-PHOSPH-RXN xref: RHEA:16037 is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0009033 name: trimethylamine-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9] synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9] xref: EC:1.6.6.9 xref: MetaCyc:TMAOREDUCT-RXN xref: RHEA:22024 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0009034 name: tryptophanase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H(2)O = indole + NH(4)(+) + pyruvate." [EC:4.1.99.1, RHEA:19553] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] synonym: "TNase activity" EXACT [EC:4.1.99.1] synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] xref: EC:4.1.99.1 xref: KEGG:R00673 xref: MetaCyc:TRYPDEG-PWY xref: MetaCyc:TRYPTOPHAN-RXN xref: RHEA:19553 xref: UniPathway:UPA00332 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0009035 name: type I site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] synonym: "type I restriction enzyme activity" EXACT [] synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] xref: EC:3.1.21.3 xref: MetaCyc:3.1.21.3-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009036 name: type II site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] synonym: "type II restriction enzyme activity" EXACT [] xref: EC:3.1.21.4 xref: MetaCyc:3.1.21.4-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009037 name: tyrosine-based site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] synonym: "site-specific tyrosine recombinase activity" EXACT [] synonym: "tyrosine recombinase" BROAD [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity [Term] id: GO:0009038 name: undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66, RHEA:23752] synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase (phosphorylating)" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid alcohol phosphokinase activity" BROAD [EC:2.7.1.66] synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "polyisoprenol kinase activity" BROAD [EC:2.7.1.66] xref: EC:2.7.1.66 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009039 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: MetaCyc:UREASE-RXN xref: RHEA:25346 xref: UM-BBD_reactionID:r0120 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009040 name: ureidoglycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + NAD(P)+ = oxalureate + NAD(P)H + H+." [EC:1.1.1.154, PMID:23284870] synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] xref: EC:1.1.1.154 xref: MetaCyc:R165-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009041 name: uridylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] xref: EC:2.7.4 is_a: GO:0050145 ! nucleoside monophosphate kinase activity [Term] id: GO:0009042 name: valine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66, RHEA:22912] synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "transaminase C activity" NARROW [EC:2.6.1.66] synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "valine-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.66 xref: KEGG:R01215 xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN xref: RHEA:22912 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009044 name: xylan 1,4-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "xylobiase activity" EXACT [EC:3.2.1.37] xref: EC:3.2.1.37 xref: MetaCyc:3.2.1.37-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0009045 name: xylose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] xref: EC:5.3.1.5 xref: MetaCyc:XYLISOM-RXN xref: RHEA:22816 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0009046 name: zinc D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] synonym: "G enzyme" RELATED [EC:3.4.17.14] synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] xref: EC:3.4.17.14 xref: MetaCyc:3.4.17.14-RXN is_a: GO:0004181 ! metallocarboxypeptidase activity [Term] id: GO:0009047 name: dosage compensation by hyperactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0140512888, PMID:11498577, PMID:20622855] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009048 name: dosage compensation by inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, GOC:mr, GOC:pr, https://en.wikipedia.org/wiki/XY_sex-determination_system, ISBN:0140512888, PMID:11498577, PMID:20622855] synonym: "Barr body formation" RELATED [] synonym: "chromosome inactivation" BROAD [] synonym: "X chromosome inactivation" EXACT [] xref: Wikipedia:X-inactivation is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009049 name: obsolete aspartic-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. synonym: "aspartic-type signal peptidase activity" EXACT [] xref: EC:3.4.23 is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009050 name: glycopeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732] synonym: "glycopeptide breakdown" EXACT [] synonym: "glycopeptide catabolism" EXACT [] synonym: "glycopeptide degradation" EXACT [] is_a: GO:0043171 ! peptide catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009051 name: pentose-phosphate shunt, oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732, MetaCyc:OXIDATIVEPENT-PWY] synonym: "oxidative branch, pentose pathway" EXACT [] synonym: "oxidative pentose phosphate pathway" EXACT [] synonym: "pentose phosphate pathway, oxidative branch" EXACT [] synonym: "pentose phosphate shunt, oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] xref: MetaCyc:OXIDATIVEPENT-PWY is_a: GO:0006740 ! NADPH regeneration is_a: GO:0051156 ! glucose 6-phosphate metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009052 name: pentose-phosphate shunt, non-oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732, MetaCyc:NONOXIPENT-PWY] synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] xref: MetaCyc:NONOXIPENT-PWY xref: MetaCyc:P21-PWY is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:1901135 ! carbohydrate derivative metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009055 name: electron transfer activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport chain. An electron transport chain is a process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transporter activity" RELATED [] xref: reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" xref: reactome:R-HSA-169260 "Reducing equivalents from beta-oxidation of fatty acids transfer to ETF" xref: reactome:R-HSA-2564826 "4Fe-4S cluster assembles on NUBP2:NUBP1 scaffold" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0009056 name: catabolic process namespace: biological_process alt_id: GO:0044243 alt_id: GO:0044712 def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] synonym: "multicellular organismal catabolic process" NARROW [] synonym: "single-organism catabolic process" RELATED [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 alt_id: GO:0044266 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: goslim_pir synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] synonym: "multicellular organismal macromolecule catabolic process" NARROW [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process alt_id: GO:0044274 alt_id: GO:0044711 def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" BROAD [] synonym: "multicellular organismal biosynthetic process" NARROW [] synonym: "single-organism biosynthetic process" RELATED [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [CHEBI:33694, GOC:mah] subset: goslim_pir synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009060 name: aerobic respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] xref: MetaCyc:PWY-3781 xref: Wikipedia:Cellular_respiration#Aerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009061 name: anaerobic respiration namespace: biological_process def: "The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:das, GOC:jl, ISBN:0140513590] xref: MetaCyc:ANARESP1-PWY xref: Wikipedia:Anaerobic_respiration xref: Wikipedia:Cellular_respiration#Anaerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009062 name: fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] synonym: "fatty acid breakdown" EXACT [] synonym: "fatty acid catabolism" EXACT [] synonym: "fatty acid degradation" EXACT [] xref: Wikipedia:Fatty_acid_degradation is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009063 name: cellular amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] synonym: "amino acid catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid breakdown" EXACT [] synonym: "cellular amino acid catabolism" EXACT [] synonym: "cellular amino acid degradation" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009066 name: aspartate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009068 name: aspartate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] synonym: "aspartate family amino acid breakdown" EXACT [] synonym: "aspartate family amino acid catabolism" EXACT [] synonym: "aspartate family amino acid degradation" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009071 name: serine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] synonym: "serine family amino acid breakdown" EXACT [] synonym: "serine family amino acid catabolism" EXACT [] synonym: "serine family amino acid degradation" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009072 name: aromatic amino acid family metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009073 name: aromatic amino acid family biosynthetic process namespace: biological_process alt_id: GO:0016089 def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family anabolism" EXACT [] synonym: "aromatic amino acid family biosynthesis" EXACT [] synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] synonym: "aromatic amino acid family formation" EXACT [] synonym: "aromatic amino acid family synthesis" EXACT [] xref: MetaCyc:COMPLETE-ARO-PWY is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009074 name: aromatic amino acid family catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] synonym: "aromatic amino acid family breakdown" EXACT [] synonym: "aromatic amino acid family catabolism" EXACT [] synonym: "aromatic amino acid family degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0009075 name: obsolete histidine family amino acid metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid metabolic process" EXACT [] synonym: "histidine family amino acid metabolism" EXACT [] is_obsolete: true replaced_by: GO:0006547 [Term] id: GO:0009076 name: obsolete histidine family amino acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid anabolism" EXACT [] synonym: "histidine family amino acid biosynthesis" EXACT [] synonym: "histidine family amino acid biosynthetic process" EXACT [] synonym: "histidine family amino acid formation" EXACT [] synonym: "histidine family amino acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0000105 [Term] id: GO:0009077 name: obsolete histidine family amino acid catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term, as histidine would be the only member of this family. synonym: "histidine family amino acid breakdown" EXACT [] synonym: "histidine family amino acid catabolic process" EXACT [] synonym: "histidine family amino acid catabolism" EXACT [] synonym: "histidine family amino acid degradation" EXACT [] is_obsolete: true replaced_by: GO:0006548 [Term] id: GO:0009078 name: pyruvate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid metabolism" EXACT [] is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0009079 name: pyruvate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid anabolism" EXACT [] synonym: "pyruvate family amino acid biosynthesis" EXACT [] synonym: "pyruvate family amino acid formation" EXACT [] synonym: "pyruvate family amino acid synthesis" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009080 name: pyruvate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] synonym: "pyruvate family amino acid breakdown" EXACT [] synonym: "pyruvate family amino acid catabolism" EXACT [] synonym: "pyruvate family amino acid degradation" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0009081 name: branched-chain amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai] synonym: "branched chain family amino acid metabolism" EXACT [GOC:ai] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009082 name: branched-chain amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [CHEBI:22918, GOC:ai] synonym: "branched chain family amino acid anabolism" EXACT [] synonym: "branched chain family amino acid biosynthesis" EXACT [] synonym: "branched chain family amino acid biosynthetic process" EXACT [GOC:ai] synonym: "branched chain family amino acid formation" EXACT [] synonym: "branched chain family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009081 ! branched-chain amino acid metabolic process [Term] id: GO:0009083 name: branched-chain amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] synonym: "branched chain family amino acid breakdown" EXACT [] synonym: "branched chain family amino acid catabolic process" EXACT [GOC:ai] synonym: "branched chain family amino acid catabolism" EXACT [] synonym: "branched chain family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009081 ! branched-chain amino acid metabolic process [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009086 name: methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine anabolism" EXACT [] synonym: "methionine biosynthesis" EXACT [] synonym: "methionine formation" EXACT [] synonym: "methionine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009087 name: methionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "methionine breakdown" EXACT [] synonym: "methionine catabolism" EXACT [] synonym: "methionine degradation" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0009088 name: threonine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] synonym: "threonine anabolism" EXACT [] synonym: "threonine biosynthesis" EXACT [] synonym: "threonine formation" EXACT [] synonym: "threonine synthesis" EXACT [] xref: MetaCyc:HOMOSER-THRESYN-PWY xref: MetaCyc:THRESYN-PWY is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009089 name: lysine biosynthetic process via diaminopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] synonym: "diaminopimelate pathway" EXACT [] synonym: "diaminopimelic acid pathway" EXACT [] synonym: "lysine anabolism via diaminopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] synonym: "lysine formation via diaminopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate" EXACT [] is_a: GO:0009085 ! lysine biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0009090 name: homoserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine anabolism" EXACT [] synonym: "homoserine biosynthesis" EXACT [] synonym: "homoserine formation" EXACT [] synonym: "homoserine synthesis" EXACT [] xref: MetaCyc:HOMOSERSYN-PWY is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009091 name: homoserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine breakdown" EXACT [] synonym: "homoserine catabolism" EXACT [] synonym: "homoserine degradation" EXACT [] xref: MetaCyc:HOMOCYSDEGR-PWY is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009092 name: homoserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732] synonym: "homoserine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009093 name: cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine breakdown" EXACT [] synonym: "cysteine catabolism" EXACT [] synonym: "cysteine degradation" EXACT [] xref: Wikipedia:Cysteine is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0009094 name: L-phenylalanine biosynthetic process namespace: biological_process alt_id: GO:0019274 alt_id: GO:0019275 def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [CHEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-phenylalanine anabolism" EXACT [] synonym: "L-phenylalanine biosynthesis" EXACT [] synonym: "L-phenylalanine formation" EXACT [] synonym: "L-phenylalanine synthesis" EXACT [] synonym: "phenylalanine biosynthesis" BROAD [] synonym: "phenylalanine biosynthetic process" BROAD [] synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway is_a: GO:1902223 ! erythrose 4-phosphate/phosphoenolpyruvate family amino acid biosynthetic process [Term] id: GO:0009095 name: aromatic amino acid family biosynthetic process, prephenate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309] synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] synonym: "aromatic amino acid family biosynthetic process via prephenate" EXACT [GOC:pr] synonym: "aromatic amino acid family biosynthetic process via prephenate(2-)" EXACT [GOC:pr] synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process [Term] id: GO:0009097 name: isoleucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] synonym: "isoleucine anabolism" EXACT [] synonym: "isoleucine biosynthesis" EXACT [] synonym: "isoleucine formation" EXACT [] synonym: "isoleucine synthesis" EXACT [] xref: MetaCyc:ILEUSYN-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009098 name: leucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] synonym: "leucine anabolism" EXACT [] synonym: "leucine biosynthesis" EXACT [] synonym: "leucine formation" EXACT [] synonym: "leucine synthesis" EXACT [] xref: MetaCyc:LEUSYN-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009099 name: valine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] synonym: "valine anabolism" EXACT [] synonym: "valine biosynthesis" EXACT [] synonym: "valine formation" EXACT [] synonym: "valine synthesis" EXACT [] xref: MetaCyc:VALSYN-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009082 ! branched-chain amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732] synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009102 name: biotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732] synonym: "biotin anabolism" EXACT [] synonym: "biotin biosynthesis" EXACT [] synonym: "biotin formation" EXACT [] synonym: "biotin synthesis" EXACT [] synonym: "vitamin B7 biosynthesis" EXACT [] synonym: "vitamin B7 biosynthetic process" EXACT [] synonym: "vitamin H biosynthesis" EXACT [] synonym: "vitamin H biosynthetic process" EXACT [] xref: MetaCyc:BIOTIN-SYNTHESIS-PWY is_a: GO:0006768 ! biotin metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009103 name: lipopolysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai, GOC:mr] synonym: "lipopolysaccharide anabolism" EXACT [] synonym: "lipopolysaccharide biosynthesis" EXACT [] synonym: "lipopolysaccharide formation" EXACT [] synonym: "lipopolysaccharide synthesis" EXACT [] synonym: "LPS biosynthetic process" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009104 name: lipopolysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] synonym: "lipopolysaccharide breakdown" EXACT [] synonym: "lipopolysaccharide catabolism" EXACT [] synonym: "lipopolysaccharide degradation" EXACT [] synonym: "LPS catabolic process" EXACT [] is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009106 name: lipoate metabolic process namespace: biological_process alt_id: GO:0000273 def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] synonym: "lipoate metabolism" EXACT [] synonym: "lipoic acid metabolic process" EXACT [] synonym: "lipoic acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009107 name: lipoate biosynthetic process namespace: biological_process alt_id: GO:0009105 def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732] synonym: "lipoate anabolism" EXACT [] synonym: "lipoate biosynthesis" EXACT [] synonym: "lipoate formation" EXACT [] synonym: "lipoate synthesis" EXACT [] synonym: "lipoic acid anabolism" EXACT [] synonym: "lipoic acid biosynthesis" EXACT [] synonym: "lipoic acid biosynthetic process" EXACT [] synonym: "lipoic acid formation" EXACT [] synonym: "lipoic acid synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009108 name: coenzyme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009109 name: coenzyme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "coenzyme breakdown" EXACT [] synonym: "coenzyme catabolism" EXACT [] synonym: "coenzyme degradation" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0009110 name: vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732] synonym: "vitamin anabolism" EXACT [] synonym: "vitamin biosynthesis" EXACT [] synonym: "vitamin formation" EXACT [] synonym: "vitamin synthesis" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0009111 name: vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] synonym: "vitamin breakdown" EXACT [] synonym: "vitamin catabolism" EXACT [] synonym: "vitamin degradation" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] synonym: "nucleobase metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009113 name: purine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [CHEBI:26386, GOC:go_curators, ISBN:0198506732] synonym: "purine base anabolism" EXACT [] synonym: "purine base biosynthesis" EXACT [] synonym: "purine base biosynthetic process" EXACT [GOC:go_curators] synonym: "purine base formation" EXACT [] synonym: "purine base synthesis" EXACT [] xref: MetaCyc:PWY-841 is_a: GO:0006144 ! purine nucleobase metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0009114 name: hypoxanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] synonym: "hypoxanthine breakdown" EXACT [] synonym: "hypoxanthine catabolism" EXACT [] synonym: "hypoxanthine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0009115 name: xanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] synonym: "xanthine breakdown" EXACT [] synonym: "xanthine catabolism" EXACT [] synonym: "xanthine degradation" EXACT [] is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009118 name: regulation of nucleoside metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] synonym: "regulation of nucleoside metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [CHEBI:18254, GOC:jl] synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009120 name: deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009125 name: nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside monophosphate breakdown" EXACT [] synonym: "nucleoside monophosphate catabolism" EXACT [] synonym: "nucleoside monophosphate degradation" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009128 name: purine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside monophosphate breakdown" EXACT [] synonym: "purine nucleoside monophosphate catabolism" EXACT [] synonym: "purine nucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009129 name: pyrimidine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009130 name: pyrimidine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009131 name: pyrimidine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009133 name: nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate anabolism" EXACT [] synonym: "nucleoside diphosphate biosynthesis" EXACT [] synonym: "nucleoside diphosphate formation" EXACT [] synonym: "nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009134 name: nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside diphosphate breakdown" EXACT [] synonym: "nucleoside diphosphate catabolism" EXACT [] synonym: "nucleoside diphosphate degradation" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009135 name: purine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009136 name: purine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate anabolism" EXACT [] synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] synonym: "purine nucleoside diphosphate formation" EXACT [] synonym: "purine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009137 name: purine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside diphosphate breakdown" EXACT [] synonym: "purine nucleoside diphosphate catabolism" EXACT [] synonym: "purine nucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009138 name: pyrimidine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009139 name: pyrimidine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009140 name: pyrimidine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009143 name: nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose or ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "nucleoside triphosphate breakdown" EXACT [] synonym: "nucleoside triphosphate catabolism" EXACT [] synonym: "nucleoside triphosphate degradation" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009146 name: purine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a compound consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine nucleoside triphosphate breakdown" EXACT [] synonym: "purine nucleoside triphosphate catabolism" EXACT [] synonym: "purine nucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009147 name: pyrimidine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009148 name: pyrimidine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009149 name: pyrimidine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009151 name: purine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009153 name: purine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide anabolism" EXACT [] synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] synonym: "purine deoxyribonucleotide formation" EXACT [] synonym: "purine deoxyribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009154 name: purine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleotide breakdown" EXACT [] synonym: "purine ribonucleotide catabolism" EXACT [] synonym: "purine ribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009155 name: purine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleotide breakdown" EXACT [] synonym: "purine deoxyribonucleotide catabolism" EXACT [] synonym: "purine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009157 name: deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside monophosphate formation" EXACT [] synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009158 name: ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate breakdown" EXACT [] synonym: "ribonucleoside monophosphate catabolism" EXACT [] synonym: "ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009159 name: deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009162 name: deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034404 ! nucleobase-containing small molecule biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0009164 name: nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] synonym: "nucleoside breakdown" EXACT [] synonym: "nucleoside catabolism" EXACT [] synonym: "nucleoside degradation" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901293 ! nucleoside phosphate biosynthetic process [Term] id: GO:0009166 name: nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] synonym: "nucleotide breakdown" EXACT [] synonym: "nucleotide catabolism" EXACT [] synonym: "nucleotide degradation" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901292 ! nucleoside phosphate catabolic process [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009169 name: purine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a compound consisting of a purine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] synonym: "purine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009170 name: purine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009171 name: purine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009172 name: purine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009173 name: pyrimidine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009174 name: pyrimidine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process [Term] id: GO:0009175 name: pyrimidine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process [Term] id: GO:0009176 name: pyrimidine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009177 name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009178 name: pyrimidine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009180 name: purine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside diphosphate formation" EXACT [] synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process [Term] id: GO:0009181 name: purine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] synonym: "purine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process [Term] id: GO:0009182 name: purine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009183 name: purine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process [Term] id: GO:0009184 name: purine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process [Term] id: GO:0009185 name: ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009186 name: deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009187 name: cyclic nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009188 name: ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate anabolism" EXACT [] synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "ribonucleoside diphosphate formation" EXACT [] synonym: "ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009189 name: deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside diphosphate formation" EXACT [] synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009190 name: cyclic nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide anabolism" EXACT [] synonym: "cyclic nucleotide biosynthesis" EXACT [] synonym: "cyclic nucleotide formation" EXACT [] synonym: "cyclic nucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009191 name: ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside diphosphate breakdown" EXACT [] synonym: "ribonucleoside diphosphate catabolism" EXACT [] synonym: "ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009192 name: deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009193 name: pyrimidine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009194 name: pyrimidine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0009195 name: pyrimidine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process [Term] id: GO:0009196 name: pyrimidine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009197 name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009198 name: pyrimidine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009200 name: deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009202 name: deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside triphosphate formation" EXACT [] synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009203 name: ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a compound consisting of a nucleobase linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleoside triphosphate breakdown" EXACT [] synonym: "ribonucleoside triphosphate catabolism" EXACT [] synonym: "ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009204 name: deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a compound consisting of a nucleobase linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009207 name: purine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] synonym: "purine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009208 name: pyrimidine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009209 name: pyrimidine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process [Term] id: GO:0009210 name: pyrimidine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process [Term] id: GO:0009211 name: pyrimidine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009212 name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009213 name: pyrimidine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a compound consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009214 name: cyclic nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732] synonym: "cyclic nucleotide breakdown" EXACT [] synonym: "cyclic nucleotide catabolism" EXACT [] synonym: "cyclic nucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009215 name: purine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009216 name: purine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009217 name: purine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a compound consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009218 name: pyrimidine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009219 name: pyrimidine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009220 name: pyrimidine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide anabolism" EXACT [] synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine ribonucleotide formation" EXACT [] synonym: "pyrimidine ribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-162 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009221 name: pyrimidine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-166 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009222 name: pyrimidine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine ribonucleotide breakdown" EXACT [] synonym: "pyrimidine ribonucleotide catabolism" EXACT [] synonym: "pyrimidine ribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009223 name: pyrimidine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process [Term] id: GO:0009224 name: CMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732] synonym: "CMP anabolism" EXACT [] synonym: "CMP biosynthesis" EXACT [] synonym: "CMP formation" EXACT [] synonym: "CMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0009225 name: nucleotide-sugar metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] comment: Added parent as requested here https://github.com/geneontology/go-ontology/issues/14587 subset: goslim_pir synonym: "nucleotide-sugar metabolism" EXACT [] is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009226 name: nucleotide-sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar anabolism" EXACT [] synonym: "nucleotide-sugar biosynthesis" EXACT [] synonym: "nucleotide-sugar formation" EXACT [] synonym: "nucleotide-sugar synthesis" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009227 name: nucleotide-sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar breakdown" EXACT [] synonym: "nucleotide-sugar catabolism" EXACT [] synonym: "nucleotide-sugar degradation" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0034656 ! nucleobase-containing small molecule catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009228 name: thiamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] synonym: "thiamin anabolism" EXACT [] synonym: "thiamin biosynthetic process" EXACT [GOC:curators] synonym: "thiamine biosynthesis" EXACT [GOC:curators] synonym: "thiamine formation" EXACT [GOC:curators] synonym: "thiamine synthesis" EXACT [GOC:curators] synonym: "vitamin B1 biosynthesis" EXACT [] synonym: "vitamin B1 biosynthetic process" EXACT [] xref: MetaCyc:THISYN-PWY is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042724 ! thiamine-containing compound biosynthetic process [Term] id: GO:0009229 name: thiamine diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [CHEBI:45931, GOC:jl, ISBN:0140512713] synonym: "thiamin diphosphate biosynthetic process" EXACT [GOC:cuators] synonym: "thiamin pyrophosphate biosynthesis" EXACT [] synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] synonym: "thiamine diphosphate anabolism" EXACT [GOC:curators] synonym: "thiamine diphosphate biosynthesis" EXACT [GOC:curators] synonym: "thiamine diphosphate formation" EXACT [GOC:curators] synonym: "thiamine diphosphate synthesis" EXACT [GOC:curators] synonym: "thiamine pyrophosphate biosynthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] synonym: "TPP biosynthesis" EXACT [] synonym: "TPP biosynthetic process" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042357 ! thiamine diphosphate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0009230 name: thiamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [CHEBI:18385, GOC:jl, ISBN:0198506732] synonym: "thiamin catabolic process" EXACT [GOC:curators] synonym: "thiamine breakdown" EXACT [GOC:curators] synonym: "thiamine catabolism" EXACT [GOC:curators] synonym: "thiamine degradation" EXACT [GOC:curators] synonym: "vitamin B1 catabolic process" EXACT [] synonym: "vitamin B1 catabolism" EXACT [] is_a: GO:0006772 ! thiamine metabolic process is_a: GO:0042725 ! thiamine-containing compound catabolic process [Term] id: GO:0009231 name: riboflavin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin anabolism" EXACT [] synonym: "riboflavin biosynthesis" EXACT [] synonym: "riboflavin formation" EXACT [] synonym: "riboflavin synthesis" EXACT [] synonym: "vitamin B2 biosynthesis" EXACT [] synonym: "vitamin B2 biosynthetic process" EXACT [] synonym: "vitamin G biosynthesis" EXACT [] synonym: "vitamin G biosynthetic process" EXACT [] xref: MetaCyc:RIBOSYN2-PWY xref: Wikipedia:Riboflavin is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process [Term] id: GO:0009232 name: riboflavin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] synonym: "riboflavin breakdown" EXACT [] synonym: "riboflavin catabolism" EXACT [] synonym: "riboflavin degradation" EXACT [] synonym: "vitamin B2 catabolic process" EXACT [] synonym: "vitamin B2 catabolism" EXACT [] synonym: "vitamin G catabolic process" EXACT [] synonym: "vitamin G catabolism" EXACT [] is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0009233 name: menaquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "menaquinone metabolism" EXACT [] synonym: "menatetrenone metabolic process" EXACT [] synonym: "menatetrenone metabolism" EXACT [] synonym: "multiprenylmenaquinone metabolic process" EXACT [] synonym: "multiprenylmenaquinone metabolism" EXACT [] synonym: "vitamin K2 metabolic process" EXACT [] synonym: "vitamin K2 metabolism" EXACT [] is_a: GO:1901661 ! quinone metabolic process [Term] id: GO:0009234 name: menaquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] synonym: "menaquinone anabolism" EXACT [] synonym: "menaquinone biosynthesis" EXACT [] synonym: "menaquinone formation" EXACT [] synonym: "menaquinone synthesis" EXACT [] synonym: "menatetrenone biosynthesis" EXACT [] synonym: "menatetrenone biosynthetic process" EXACT [] synonym: "multiprenylmenaquinone biosynthesis" EXACT [] synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K2 biosynthesis" EXACT [] synonym: "vitamin K2 biosynthetic process" EXACT [] xref: MetaCyc:MENAQUINONESYN-PWY is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0009235 name: cobalamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] synonym: "cobalamin metabolism" EXACT [] synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009236 name: cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732] synonym: "cobalamin anabolism" EXACT [] synonym: "cobalamin biosynthesis" EXACT [] synonym: "cobalamin formation" EXACT [] synonym: "cobalamin synthesis" EXACT [] synonym: "vitamin B12 biosynthesis" EXACT [] synonym: "vitamin B12 biosynthetic process" EXACT [] is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009237 name: siderophore metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] synonym: "siderochrome metabolic process" NARROW [] synonym: "siderochrome metabolism" NARROW [] synonym: "siderophore metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009238 name: enterobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] synonym: "enterobactin metabolism" EXACT [] synonym: "enterochelin metabolic process" EXACT [] synonym: "enterochelin metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009239 name: enterobactin biosynthetic process namespace: biological_process alt_id: GO:0031191 alt_id: GO:0031192 def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] synonym: "enterobactin anabolism" EXACT [] synonym: "enterobactin biosynthesis" EXACT [] synonym: "enterobactin biosynthetic process, peptide formation" NARROW [] synonym: "enterobactin biosynthetic process, peptide modification" NARROW [] synonym: "enterobactin formation" EXACT [] synonym: "enterobactin synthesis" EXACT [] synonym: "enterobactin synthetase" RELATED [] synonym: "enterochelin biosynthesis" EXACT [] synonym: "enterochelin biosynthetic process" EXACT [] xref: MetaCyc:ENTBACSYN-PWY is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol [Term] id: GO:0009240 name: isopentenyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732] synonym: "IPP biosynthesis" EXACT [] synonym: "IPP biosynthetic process" EXACT [] synonym: "isopentenyl diphosphate anabolism" EXACT [] synonym: "isopentenyl diphosphate biosynthesis" EXACT [] synonym: "isopentenyl diphosphate formation" EXACT [] synonym: "isopentenyl diphosphate synthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046490 ! isopentenyl diphosphate metabolic process relationship: part_of GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0009242 name: colanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] synonym: "colanic acid anabolism" EXACT [] synonym: "colanic acid biosynthesis" EXACT [] synonym: "colanic acid formation" EXACT [] synonym: "colanic acid synthesis" EXACT [] synonym: "M antigen biosynthesis" EXACT [] synonym: "M antigen biosynthetic process" EXACT [] xref: MetaCyc:COLANSYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046377 ! colanic acid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009243 name: O antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732] synonym: "O antigen anabolism" EXACT [] synonym: "O antigen biosynthesis" EXACT [] synonym: "O antigen formation" EXACT [] synonym: "O antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046402 ! O antigen metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009244 name: lipopolysaccharide core region biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732] synonym: "lipopolysaccharide core region anabolism" EXACT [] synonym: "lipopolysaccharide core region biosynthesis" EXACT [] synonym: "lipopolysaccharide core region formation" EXACT [] synonym: "lipopolysaccharide core region synthesis" EXACT [] synonym: "LPS core region biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0046401 ! lipopolysaccharide core region metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009245 name: lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common." [ISBN:0198506732, PMID:20974832, PMID:22216004] synonym: "lipid A anabolism" EXACT [] synonym: "lipid A biosynthesis" EXACT [] synonym: "lipid A formation" EXACT [] synonym: "lipid A synthesis" EXACT [] xref: MetaCyc:NAGLIPASYN-PWY is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0046493 ! lipid A metabolic process is_a: GO:1901271 ! lipooligosaccharide biosynthetic process [Term] id: GO:0009246 name: enterobacterial common antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] synonym: "enterobacterial common antigen anabolism" EXACT [] synonym: "enterobacterial common antigen biosynthesis" EXACT [] synonym: "enterobacterial common antigen formation" EXACT [] synonym: "enterobacterial common antigen synthesis" EXACT [] xref: MetaCyc:ECASYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046378 ! enterobacterial common antigen metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009247 name: glycolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] synonym: "glycolipid anabolism" EXACT [] synonym: "glycolipid biosynthesis" EXACT [] synonym: "glycolipid formation" EXACT [] synonym: "glycolipid synthesis" EXACT [] xref: MetaCyc:PWY-401 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009248 name: K antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732] synonym: "K antigen anabolism" EXACT [] synonym: "K antigen biosynthesis" EXACT [] synonym: "K antigen formation" EXACT [] synonym: "K antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046375 ! K antigen metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009249 name: protein lipoylation namespace: biological_process alt_id: GO:0018055 def: "The lipoylation of peptidyl-lysine to form peptidyl-N6-lipoyl-L-lysine." [RESID:AA0118] synonym: "peptidyl-lysine lipoylation" EXACT [] synonym: "protein-lipoic acid cofactor linkage" EXACT [] is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0051604 ! protein maturation [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0009252 name: peptidoglycan biosynthetic process namespace: biological_process alt_id: GO:0009285 def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein biosynthesis" EXACT [] synonym: "murein biosynthetic process" EXACT [] synonym: "peptidoglycan anabolism" EXACT [] synonym: "peptidoglycan biosynthesis" EXACT [] synonym: "peptidoglycan formation" EXACT [] synonym: "peptidoglycan synthesis" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0009253 name: peptidoglycan catabolic process namespace: biological_process alt_id: GO:0009286 def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732] synonym: "murein catabolic process" EXACT [] synonym: "murein catabolism" EXACT [] synonym: "peptidoglycan breakdown" EXACT [] synonym: "peptidoglycan catabolism" EXACT [] synonym: "peptidoglycan degradation" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006027 ! glycosaminoglycan catabolic process [Term] id: GO:0009254 name: peptidoglycan turnover namespace: biological_process alt_id: GO:0009287 def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] synonym: "murein turnover" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process [Term] id: GO:0009255 name: Entner-Doudoroff pathway through 6-phosphogluconate namespace: biological_process def: "A pathway that converts a carbohydrate to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, MetaCyc:ENTNER-DOUDOROFF-PWY-I, PMID:12921356] xref: MetaCyc:ENTNER-DOUDOROFF-PWY-I xref: PMID:12981024 is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0061678 ! Entner-Doudoroff pathway [Term] id: GO:0009256 name: 10-formyltetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF metabolic process" EXACT [] synonym: "10-formyl-THF metabolism" EXACT [] synonym: "10-formyltetrahydrofolate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0009257 name: 10-formyltetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF biosynthesis" EXACT [] synonym: "10-formyl-THF biosynthetic process" EXACT [] synonym: "10-formyltetrahydrofolate anabolism" EXACT [] synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] synonym: "10-formyltetrahydrofolate formation" EXACT [] synonym: "10-formyltetrahydrofolate synthesis" EXACT [] xref: MetaCyc:1CMET2-PWY xref: MetaCyc:PWY-3841 is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046654 ! tetrahydrofolate biosynthetic process [Term] id: GO:0009258 name: 10-formyltetrahydrofolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] synonym: "10-formyl-THF catabolic process" EXACT [] synonym: "10-formyl-THF catabolism" EXACT [] synonym: "10-formyltetrahydrofolate breakdown" EXACT [] synonym: "10-formyltetrahydrofolate catabolism" EXACT [] synonym: "10-formyltetrahydrofolate degradation" EXACT [] is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0009397 ! folic acid-containing compound catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0019693 ! ribose phosphate metabolic process [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:0046390 ! ribose phosphate biosynthetic process [Term] id: GO:0009261 name: ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "ribonucleotide breakdown" EXACT [] synonym: "ribonucleotide catabolism" EXACT [] synonym: "ribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009259 ! ribonucleotide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009262 name: deoxyribonucleotide metabolic process namespace: biological_process alt_id: GO:0009122 alt_id: GO:0009393 def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0009263 name: deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide anabolism" EXACT [] synonym: "deoxyribonucleotide biosynthesis" EXACT [] synonym: "deoxyribonucleotide formation" EXACT [] synonym: "deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0009264 name: deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:go_curators, ISBN:0198506732] synonym: "deoxyribonucleotide breakdown" EXACT [] synonym: "deoxyribonucleotide catabolism" EXACT [] synonym: "deoxyribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0009265 name: 2'-deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] synonym: "2'-deoxyribonucleotide anabolism" EXACT [] synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] synonym: "2'-deoxyribonucleotide formation" EXACT [] synonym: "2'-deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:jl, http://en.wikipedia.org/wiki/PH] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009269 name: response to desiccation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] synonym: "desiccation tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009270 name: response to humidity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] is_a: GO:0009415 ! response to water [Term] id: GO:0009271 name: phage shock namespace: biological_process def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] is_a: GO:0006950 ! response to stress is_a: GO:0098586 ! cellular response to virus [Term] id: GO:0009272 name: fungal-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [GOC:mah] synonym: "fungal-type cell wall anabolism" RELATED [GOC:mah] synonym: "fungal-type cell wall biosynthetic process" RELATED [GOC:mah] synonym: "fungal-type cell wall formation" RELATED [GOC:mah] synonym: "fungal-type cell wall synthesis" RELATED [GOC:mah] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0009273 name: peptidoglycan-based cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators] synonym: "cell envelope biosynthesis" BROAD [] synonym: "cell envelope biosynthetic process" BROAD [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0042546 ! cell wall biogenesis [Term] id: GO:0009274 name: peptidoglycan-based cell wall namespace: cellular_component def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893] synonym: "envelope" BROAD [] synonym: "murein sacculus" RELATED [] synonym: "peptidoglycan" NARROW [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009275 name: Gram-positive-bacterium-type cell wall namespace: cellular_component def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893] synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall of Gram-positive Bacteria" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall [Term] id: GO:0009276 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] subset: goslim_metagenomics synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall inner membrane" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009278 name: obsolete murein sacculus namespace: cellular_component def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "murein sacculus" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009279 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:md, GOC:mtg_sensu, ISBN:0135712254] comment: To annotate the plasma (cytoplasmic) membrane, see instead GO:0005886. synonym: "outer membrane of cell" EXACT [] is_a: GO:0019867 ! outer membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009280 name: obsolete cell wall inner membrane namespace: cellular_component def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "cell wall inner membrane" EXACT [] synonym: "cytoplasmic membrane" BROAD [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009288 name: bacterial-type flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:cilia, GOC:jh2, GOC:krc, GOC:mtg_sensu, http:en.wikipedia.org/wiki/Flagellum#Bacterial, PMID:7787060] subset: goslim_metagenomics subset: goslim_pir synonym: "flagellin-based flagellum" EXACT [] is_a: GO:0042995 ! cell projection is_a: GO:0043228 ! non-membrane-bounded organelle [Term] id: GO:0009289 name: pilus namespace: cellular_component def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] subset: goslim_pir synonym: "fimbria" EXACT [] synonym: "fimbriae" EXACT [] synonym: "fimbrium" EXACT [] synonym: "pili" EXACT [] xref: Wikipedia:Pilus is_a: GO:0042995 ! cell projection [Term] id: GO:0009290 name: DNA import into cell involved in transformation namespace: biological_process def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] synonym: "cellular DNA import during transformation" RELATED [] synonym: "cellular DNA uptake" BROAD [] synonym: "DNA import into cell" BROAD [] synonym: "DNA import into cell involved in transformation" RELATED [GOC:dph, GOC:tb] synonym: "DNA transport into cell during transformation" RELATED [] is_a: GO:0051027 ! DNA transport is_a: GO:0098657 ! import into cell relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0009291 name: unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546] is_a: GO:0000746 ! conjugation is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009292 name: genetic transfer namespace: biological_process def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] comment: GO:0009292 should not be used for annotation of phage lysogeny (integration of the bacteriophage nucleic acid into the host bacterium's genome). subset: goslim_pir synonym: "genetic exchange" BROAD [] is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0009293 name: transduction namespace: biological_process def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732] xref: Wikipedia:Transduction_(genetics) is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009294 name: DNA mediated transformation namespace: biological_process def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [ISBN:0716720094, Wikipedia:Transformation_(genetics)] synonym: "DNA-mediated transformation" EXACT [] is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a virus, bacterial cell, mitochondrion or chloroplast to which the nucleic acid is confined." [GOC:bm, GOC:ma, ISBN:3540076689] xref: Wikipedia:Nucleoid is_a: GO:0005575 ! cellular_component [Term] id: GO:0009296 name: obsolete flagellum assembly namespace: biological_process def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [GOC:curators, ISBN:0815316194] synonym: "flagella assembly" EXACT [GOC:mah] synonym: "flagella biogenesis" RELATED [] synonym: "flagellum assembly" EXACT [] synonym: "flagellum biogenesis" RELATED [GOC:mah] is_obsolete: true consider: GO:0044780 consider: GO:0060271 [Term] id: GO:0009297 name: pilus assembly namespace: biological_process def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb] synonym: "fimbria assembly" NARROW [] synonym: "fimbria biogenesis" RELATED [] synonym: "fimbriae assembly" NARROW [] synonym: "fimbriae biogenesis" RELATED [] synonym: "fimbrial assembly" NARROW [] synonym: "fimbrial biogenesis" NARROW [] synonym: "fimbrium assembly" NARROW [] synonym: "fimbrium biogenesis" RELATED [] synonym: "pili biosynthesis" EXACT [] synonym: "pili biosynthetic process" EXACT [] synonym: "pilus biogenesis" RELATED [] synonym: "pilus biosynthesis" EXACT [] synonym: "pilus formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0030031 ! cell projection assembly is_a: GO:0043711 ! pilus organization [Term] id: GO:0009298 name: GDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-mannose anabolism" EXACT [] synonym: "GDP-mannose biosynthesis" EXACT [] synonym: "GDP-mannose formation" EXACT [] synonym: "GDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019673 ! GDP-mannose metabolic process [Term] id: GO:0009299 name: mRNA transcription namespace: biological_process alt_id: GO:0061023 def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] synonym: "cellular mRNA transcription" EXACT [] synonym: "mRNA biosynthesis" BROAD [] synonym: "mRNA biosynthetic process" BROAD [] synonym: "mRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0009300 name: antisense RNA transcription namespace: biological_process def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl] is_a: GO:0006351 ! transcription, DNA-templated is_a: GO:0042868 ! antisense RNA metabolic process [Term] id: GO:0009301 name: snRNA transcription namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009302 name: snoRNA transcription namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009303 name: rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732] synonym: "rRNA biosynthesis" BROAD [] synonym: "rRNA biosynthetic process" BROAD [] synonym: "rRNA synthesis" BROAD [] is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009304 name: tRNA transcription namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] synonym: "tRNA biosynthesis" BROAD [] synonym: "tRNA biosynthetic process" BROAD [] synonym: "tRNA synthesis" BROAD [] is_a: GO:0098781 ! ncRNA transcription [Term] id: GO:0009305 name: protein biotinylation namespace: biological_process def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] synonym: "protein amino acid biotinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell." [GOC:ai] synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0002790 ! peptide secretion is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0009307 name: DNA restriction-modification system namespace: biological_process def: "A defense process found in many bacteria and archaea that protects the organism from invading foreign DNA by cleaving it with a restriction endonuclease. The organism's own DNA is protected by methylation of a specific nucleotide, which occurs immediately following replication, in the same target site as the restriction enzyme." [GOC:jl, UniProtKB-KW:KW-0680] synonym: "DNA restriction" BROAD [] is_a: GO:0006304 ! DNA modification is_a: GO:0044355 ! clearance of foreign intracellular DNA [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_pir synonym: "amine metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732] synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009311 name: oligosaccharide metabolic process namespace: biological_process alt_id: GO:0051690 def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] subset: goslim_yeast synonym: "multicellular organismal oligosaccharide metabolic process" NARROW [] synonym: "oligosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0009312 name: oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] synonym: "oligosaccharide anabolism" EXACT [] synonym: "oligosaccharide biosynthesis" EXACT [] synonym: "oligosaccharide formation" EXACT [] synonym: "oligosaccharide synthesis" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0009313 name: oligosaccharide catabolic process namespace: biological_process alt_id: GO:0051689 def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732] synonym: "multicellular organismal oligosaccharide catabolic process" NARROW [] synonym: "oligosaccharide breakdown" EXACT [] synonym: "oligosaccharide catabolism" EXACT [] synonym: "oligosaccharide degradation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009315 name: obsolete drug resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "drug resistance" EXACT [] is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0009316 name: 3-isopropylmalate dehydratase complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530] comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. synonym: "isopropylmalate isomerase complex" EXACT [] xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX is_a: GO:0044445 ! cytosolic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009317 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] subset: goslim_metagenomics subset: goslim_pir synonym: "ACCase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009318 name: exodeoxyribonuclease VII complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] is_a: GO:0044424 ! intracellular part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009319 name: cytochrome o ubiquinol oxidase complex namespace: cellular_component def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268] comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. xref: MetaCyc:CYT-O-UBIOX-CPLX is_a: GO:0070069 ! cytochrome complex is_a: GO:0098796 ! membrane protein complex is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0009320 name: phosphoribosylaminoimidazole carboxylase complex namespace: cellular_component def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009321 name: alkyl hydroperoxide reductase complex namespace: cellular_component def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, PMID:2649484] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009322 name: trimethylamine-N-oxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009323 name: ribosomal-protein-alanine N-acetyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] is_a: GO:0031248 ! protein acetyltransferase complex [Term] id: GO:0009324 name: D-amino-acid dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009325 name: nitrate reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009326 name: formate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009327 name: NAD(P)+ transhydrogenase complex (AB-specific) namespace: cellular_component def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009328 name: phenylalanine-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009329 name: acetate CoA-transferase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009330 name: DNA topoisomerase complex (ATP-hydrolyzing) namespace: cellular_component def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'. is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009331 name: glycerol-3-phosphate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.5.3] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009332 name: glutamate-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009333 name: cysteine synthase complex namespace: cellular_component def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0009334 name: 3-phenylpropionate dioxygenase complex namespace: cellular_component def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882] comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. xref: MetaCyc:HCAMULTI-CPLX is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009335 name: obsolete holo-[acyl-carrier protein] synthase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. synonym: "holo-[acyl-carrier protein] synthase complex" EXACT [] synonym: "holo-ACP synthase complex" EXACT [] is_obsolete: true consider: GO:0005835 [Term] id: GO:0009336 name: sulfate adenylyltransferase complex (ATP) namespace: cellular_component def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902503 ! adenylyltransferase complex [Term] id: GO:0009337 name: sulfite reductase complex (NADPH) namespace: cellular_component def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl] comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. synonym: "sulphite reductase complex (NADPH)" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009338 name: exodeoxyribonuclease V complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] is_a: GO:0044424 ! intracellular part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009339 name: glycolate oxidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009340 name: DNA topoisomerase IV complex namespace: cellular_component def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009341 name: beta-galactosidase complex namespace: cellular_component def: "A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species." [BRENDA:3.2.1.2, EC:3.2.1.23, PMID:15950161] subset: goslim_metagenomics is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009342 name: glutamate synthase complex (NADPH) namespace: cellular_component def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0009343 name: biotin carboxylase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009344 name: nitrite reductase complex [NAD(P)H] namespace: cellular_component def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0009345 name: glycine-tRNA ligase complex namespace: cellular_component def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854] synonym: "glycine-tRNA synthetase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009346 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: goslim_metagenomics is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009347 name: aspartate carbamoyltransferase complex namespace: cellular_component def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. is_a: GO:0044464 ! cell part is_a: GO:1990234 ! transferase complex [Term] id: GO:0009348 name: ornithine carbamoyltransferase complex namespace: cellular_component def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0009349 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: goslim_metagenomics is_a: GO:0044464 ! cell part is_a: GO:1990234 ! transferase complex [Term] id: GO:0009350 name: ethanolamine ammonia-lyase complex namespace: cellular_component def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] is_a: GO:0044424 ! intracellular part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009351 name: obsolete dihydrolipoamide S-acyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. synonym: "dihydrolipoamide S-acyltransferase complex" EXACT [] is_obsolete: true [Term] id: GO:0009352 name: obsolete dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] synonym: "dihydrolipoyl dehydrogenase complex" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0045240 consider: GO:0045254 [Term] id: GO:0009353 name: mitochondrial oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. is_a: GO:0005947 ! mitochondrial alpha-ketoglutarate dehydrogenase complex is_a: GO:0045252 ! oxoglutarate dehydrogenase complex [Term] id: GO:0009354 name: obsolete dihydrolipoamide S-succinyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. synonym: "dihydrolipoamide S-succinyltransferase complex" EXACT [] is_obsolete: true consider: GO:0045252 [Term] id: GO:0009355 name: DNA polymerase V complex namespace: cellular_component def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009356 name: aminodeoxychorismate synthase complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] synonym: "ADC synthase complex" EXACT [] synonym: "p-aminobenzoate synthetase complex" RELATED [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009357 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups is_a: GO:1902495 ! transmembrane transporter complex [Term] id: GO:0009358 name: polyphosphate kinase complex namespace: cellular_component def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. is_a: GO:0044464 ! cell part is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0009359 name: type II site-specific deoxyribonuclease complex namespace: cellular_component def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] synonym: "type II restriction enzyme complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1905347 ! endodeoxyribonuclease complex [Term] id: GO:0009360 name: DNA polymerase III complex namespace: cellular_component def: "The DNA polymerase III holoenzyme is a complex that contains 10 different types of subunits. These subunits are organized into 3 functionally essential sub-assemblies: the pol III core, the beta sliding clamp processivity factor and the clamp-loading complex. The pol III core carries out the polymerase and the 3'-5' exonuclease proofreading activities. The polymerase is tethered to the template via the sliding clamp processivity factor. The clamp-loading complex assembles the beta processivity factor onto the primer template and plays a central role in the organization and communication at the replication fork." [PMID:11525729, PMID:12940977, UniProt:P06710] synonym: "DNA polymerase III holoenzyme complex" EXACT [] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009361 name: succinate-CoA ligase complex (ADP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394] is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0009365 name: protein histidine kinase complex namespace: cellular_component def: "A complex that possesses protein histidine kinase activity." [GOC:mah] is_a: GO:1902911 ! protein kinase complex [Term] id: GO:0009366 name: enterobactin synthetase complex namespace: cellular_component def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415] synonym: "enterochelin synthetase complex" EXACT [] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009367 name: obsolete prepilin peptidase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer. synonym: "prepilin peptidase complex" EXACT [] is_obsolete: true [Term] id: GO:0009368 name: endopeptidase Clp complex namespace: cellular_component def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009371 name: positive regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by pheromones" NARROW [] synonym: "stimulation of transcription by pheromones" NARROW [] synonym: "up regulation of transcription by pheromones" EXACT [] synonym: "up-regulation of transcription by pheromones" EXACT [] synonym: "upregulation of transcription by pheromones" EXACT [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045893 ! positive regulation of transcription, DNA-templated [Term] id: GO:0009372 name: quorum sensing namespace: biological_process def: "The process in which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518] subset: goslim_metagenomics subset: goslim_pir synonym: "quorum sensing system" EXACT [] xref: Wikipedia:Quorum_sensing is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0009373 name: regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: part_of GO:0071444 ! cellular response to pheromone [Term] id: GO:0009374 name: biotin binding namespace: molecular_function def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732] synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0009375 name: ferredoxin hydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] synonym: "hydrogenase complex" BROAD [] is_a: GO:0044424 ! intracellular part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0009376 name: HslUV protease complex namespace: cellular_component def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other ClpX family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, a double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer." [GOC:bhm, PMID:12670962, UniProt:P0A6H5] synonym: "ClpYQ protease complex" EXACT [] is_a: GO:0031597 ! cytosolic proteasome complex is_a: GO:1904949 ! ATPase complex [Term] id: GO:0009377 name: obsolete HslUV protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] comment: This term was made obsolete because it represents a gene product. synonym: "HslUV protease activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0009378 name: four-way junction helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] synonym: "Holliday junction helicase activity" NARROW [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0009379 name: Holliday junction helicase complex namespace: cellular_component def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA." [PMID:16935884, PMID:9442895] is_a: GO:0033202 ! DNA helicase complex relationship: part_of GO:0048476 ! Holliday junction resolvase complex [Term] id: GO:0009380 name: excinuclease repair complex namespace: cellular_component def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and two B subunits bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between B subunits and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:12145219, PMID:15192705] synonym: "excinuclease ABC complex" EXACT [] synonym: "UvrABC excinuclease complex" EXACT [] is_a: GO:0044424 ! intracellular part is_a: GO:1905347 ! endodeoxyribonuclease complex is_a: GO:1990391 ! DNA repair complex [Term] id: GO:0009381 name: excinuclease ABC activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0009382 name: imidazoleglycerol-phosphate synthase complex namespace: cellular_component def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990234 ! transferase complex [Term] id: GO:0009383 name: rRNA (cytosine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] synonym: "rRNA m5C967 methyltransferase activity" NARROW [] xref: reactome:R-HSA-6790944 "NOP2 (NSUN1) methylates cytidine-4447 of 28S rRNA yielding 5-methylcytidine-4447" xref: reactome:R-HSA-6793057 "NSUN4 methylates cytidine-841 of 12S rRNA yielding 5-methylcytidine-841" is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0009384 name: N-acylmannosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] xref: EC:2.7.1.60 xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN xref: reactome:R-HSA-4085028 "GNE phosphorylates ManNAc to ManNAc-6-P" xref: RHEA:23832 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009385 name: N-acylmannosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] xref: EC:5.1.3.9 xref: MetaCyc:NANE-RXN xref: RHEA:25257 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0009386 name: translational attenuation namespace: biological_process def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] is_a: GO:0006417 ! regulation of translation [Term] id: GO:0009388 name: obsolete antisense RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "antisense RNA" EXACT [] is_obsolete: true [Term] id: GO:0009389 name: dimethyl sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_reactionID:r0207] synonym: "dimethyl sulphoxide reductase activity" EXACT [] xref: EC:1.8.99 xref: UM-BBD_reactionID:r0207 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009390 name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] synonym: "dimethyl sulphoxide reductase complex" EXACT [] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0009392 name: N-acetyl-anhydromuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the reaction: GlcNAc-1,6-anhMurNAc-L-Ala-gamma-D-Glu-DAP-D-Ala + H2O glcNAc-1,6-anhMurNAc + L-Ala-gamma-D-Glu-DAP-D-Ala." [MetaCyc:RXN0-5225] xref: MetaCyc:RXN0-5225 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0009394 name: 2'-deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar." [GOC:mah] synonym: "2'-deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009262 ! deoxyribonucleotide metabolic process is_a: GO:0019692 ! deoxyribose phosphate metabolic process [Term] id: GO:0009395 name: phospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732] synonym: "phospholipid breakdown" EXACT [] synonym: "phospholipid catabolism" EXACT [] synonym: "phospholipid degradation" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0009396 name: folic acid-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] synonym: "folate and derivative biosynthesis" EXACT [] synonym: "folate and derivative biosynthetic process" EXACT [] synonym: "folate-containing compound biosynthesis" EXACT [GOC:curators] synonym: "folate-containing compound biosynthetic process" EXACT [GOC:curators] synonym: "folic acid and derivative biosynthesis" EXACT [] synonym: "folic acid and derivative biosynthetic process" EXACT [GOC:curators] synonym: "folic acid-containing compound anabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound biosynthesis" EXACT [GOC:curators] synonym: "folic acid-containing compound formation" EXACT [GOC:curators] synonym: "folic acid-containing compound synthesis" EXACT [GOC:curators] synonym: "vitamin B9 and derivative biosynthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] synonym: "vitamin M and derivative biosynthesis" EXACT [] synonym: "vitamin M and derivative biosynthetic process" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0042559 ! pteridine-containing compound biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009397 name: folic acid-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] synonym: "folate and derivative catabolic process" EXACT [] synonym: "folate and derivative catabolism" EXACT [] synonym: "folate-containing compound catabolic process" EXACT [GOC:curators] synonym: "folate-containing compound catabolism" EXACT [GOC:curators] synonym: "folic acid and derivative catabolic process" EXACT [GOC:curators] synonym: "folic acid and derivative catabolism" EXACT [] synonym: "folic acid-containing compound breakdown" EXACT [GOC:curators] synonym: "folic acid-containing compound catabolism" EXACT [GOC:curators] synonym: "folic acid-containing compound degradation" EXACT [GOC:curators] synonym: "vitamin B9 and derivative catabolic process" EXACT [] synonym: "vitamin B9 and derivative catabolism" EXACT [] synonym: "vitamin M and derivative catabolic process" EXACT [] synonym: "vitamin M and derivative catabolism" EXACT [] is_a: GO:0006760 ! folic acid-containing compound metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0009398 name: FMN biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FMN, the oxidized form of flavin mononucleotide (riboflavin 5'-(dihydrogen phosphate)), which acts as a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [CHEBI:17621, GOC:ai] synonym: "FMN anabolism" EXACT [] synonym: "FMN biosynthesis" EXACT [] synonym: "FMN formation" EXACT [] synonym: "FMN synthesis" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009260 ! ribonucleotide biosynthetic process is_a: GO:0042727 ! flavin-containing compound biosynthetic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0009399 name: nitrogen fixation namespace: biological_process def: "The process in which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation] xref: MetaCyc:N2FIX-PWY xref: Wikipedia:Nitrogen_fixation is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0009400 name: obsolete signal transducer, downstream of receptor, with serine/threonine phosphatase activity namespace: molecular_function def: "OBSOLETE. Conveys a signal from an upstream receptor or intracellular signal transducer by catalysis of the reaction: protein serine phosphate + H2O = protein serine + phosphate, and protein threonine phosphate + H2O = protein threonine + phosphate." [GOC:bf, GOC:mah] comment: This term was obsoleted because it was not clearly defined and had few annotations, see https://github.com/geneontology/go-ontology/issues/14232. synonym: "receptor signaling protein serine/threonine phosphatase activity" EXACT [] synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] is_obsolete: true [Term] id: GO:0009401 name: phosphoenolpyruvate-dependent sugar phosphotransferase system namespace: biological_process def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] synonym: "PTS system" NARROW [] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0009402 name: obsolete toxin resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "toxin resistance" EXACT [] is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_aspergillus subset: goslim_pir synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to induce an abnormal, generally detrimental state in another organism." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics synonym: "virulence" RELATED [] is_a: GO:0044419 ! interspecies interaction between organisms [Term] id: GO:0009406 name: obsolete virulence namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a phenotype rather than a biological process. synonym: "virulence" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0016032 [Term] id: GO:0009407 name: toxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] synonym: "toxin breakdown" EXACT [] synonym: "toxin catabolism" EXACT [] synonym: "toxin degradation" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0098754 ! detoxification [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: goslim_yeast synonym: "response to heat shock" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] synonym: "freezing tolerance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009410 name: response to xenobiotic stimulus namespace: biological_process alt_id: GO:0017104 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009412 name: obsolete response to heavy metal namespace: biological_process def: "OBSOLETE. Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "response to heavy metal" EXACT [] is_obsolete: true consider: GO:0010038 [Term] id: GO:0009413 name: response to flooding namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of water." [GOC:jl] synonym: "response to water stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] is_a: GO:0009314 ! response to radiation [Term] id: GO:0009417 name: obsolete fimbrin namespace: cellular_component def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] comment: This term was made obsolete because it represents a class of gene products. synonym: "fimbrin" EXACT [] is_obsolete: true replaced_by: GO:0009289 [Term] id: GO:0009418 name: pilus shaft namespace: cellular_component def: "The long, slender, mid section of a pilus." [GOC:jl] synonym: "fimbrial shaft" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009419 name: pilus tip namespace: cellular_component def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl] synonym: "fimbrial tip" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009420 name: bacterial-type flagellum filament namespace: cellular_component def: "The long (approximately 20 nm), thin external structure of the bacterial-type flagellum, which acts as a propeller." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar filament" EXACT [] synonym: "flagellin-based flagellum filament" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009421 name: bacterial-type flagellum filament cap namespace: cellular_component def: "The proteinaceous structure at the distal tip of the bacterial-type flagellar filament." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar filament cap" EXACT [] synonym: "flagellin-based flagellum filament cap" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009420 ! bacterial-type flagellum filament [Term] id: GO:0009422 name: bacterial-type flagellum hook-filament junction namespace: cellular_component def: "The region of the bacterial-type flagellum where the hook and filament meet." [GOC:cilia, GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar hook-filament junction" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009423 name: chorismate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] synonym: "chorismate anabolism" EXACT [] synonym: "chorismate biosynthesis" EXACT [] synonym: "chorismate formation" EXACT [] synonym: "chorismate synthesis" EXACT [] xref: MetaCyc:ARO-PWY is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009424 name: bacterial-type flagellum hook namespace: cellular_component def: "The portion of the bacterial-type flagellum that connects the filament to the basal body." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar hook" EXACT [] synonym: "flagellin-based flagellum hook" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009425 name: bacterial-type flagellum basal body namespace: cellular_component def: "One of the three major substructures of the bacterial-type flagellum, the basal body is embedded in the cell envelope (the plasma membrane, peptidoglycan cell wall, and, if one is present, the outer membrane); it houses the secretion apparatus that exports the more distal components and the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192, PMID:24697492] synonym: "flagellar basal body" BROAD [] synonym: "flagellin-based flagellum basal body" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009426 name: bacterial-type flagellum basal body, distal rod namespace: cellular_component def: "The portion of the central rod of the bacterial-type flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, distal rod" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009427 name: bacterial-type flagellum basal body, distal rod, L ring namespace: cellular_component def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the outer membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, distal rod, L ring" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009428 name: bacterial-type flagellum basal body, distal rod, P ring namespace: cellular_component def: "One of the rings of the bacterial-type flagellar basal body; anchors the basal body to the peptidoglycan layer." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, distal rod, P ring" RELATED [] synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009429 name: bacterial-type flagellum basal body, proximal rod namespace: cellular_component def: "The portion of the central rod of the bacterial-type flagellar basal body that is proximal to the cell membrane; the proximal rod connects the distal rod to the flagellar motor." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, proximal rod" EXACT [] synonym: "flagellin-based flagellum basal body, proximal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009431 name: bacterial-type flagellum basal body, MS ring namespace: cellular_component alt_id: GO:0009430 def: "One of the rings of the bacterial-type flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, mounting plate" BROAD [] synonym: "flagellar basal body, MS ring" EXACT [] synonym: "flagellin-based flagellum basal body, MS ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009432 name: SOS response namespace: biological_process def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, PMID:16000023] xref: Wikipedia:SOS_response is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0009433 name: bacterial-type flagellum basal body, C ring namespace: cellular_component def: "Cytoplasmic ring located at the base of the bacterial-type flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:12624192] synonym: "flagellar basal body, C ring" EXACT [] synonym: "flagellin-based flagellum basal body, C ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009435 name: NAD biosynthetic process namespace: biological_process alt_id: GO:0006736 def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) biosynthesis" EXACT [] synonym: "NAD (oxidized) biosynthetic process" EXACT [] synonym: "NAD (reduced) biosynthesis" EXACT [] synonym: "NAD (reduced) biosynthetic process" EXACT [] synonym: "NAD anabolism" EXACT [] synonym: "NAD biosynthesis" EXACT [] synonym: "NAD formation" EXACT [] synonym: "NAD synthesis" EXACT [] synonym: "NADH biosynthesis" EXACT [] synonym: "NADH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "oxidized NAD biosynthesis" EXACT [] synonym: "oxidized NAD biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "reduced NAD biosynthesis" EXACT [] synonym: "reduced NAD biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0009436 name: glyoxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732] synonym: "glyoxylate breakdown" EXACT [] synonym: "glyoxylate catabolism" EXACT [] synonym: "glyoxylate degradation" EXACT [] xref: MetaCyc:GLYOXDEG-PWY is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046487 ! glyoxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009437 name: carnitine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732] synonym: "carnitine metabolism" EXACT [] synonym: "vitamin Bt metabolic process" EXACT [] synonym: "vitamin Bt metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0009438 name: methylglyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [CHEBI:17158, GOC:ai] synonym: "methylglyoxal bypass" NARROW [] synonym: "methylglyoxal metabolism" EXACT [] synonym: "methylglyoxal pathway" NARROW [] xref: MetaCyc:METHGLYUT-PWY is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009439 name: cyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] synonym: "cyanate metabolism" EXACT [] xref: MetaCyc:CYANCAT-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009440 name: cyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732] synonym: "cyanate breakdown" EXACT [] synonym: "cyanate catabolism" EXACT [] synonym: "cyanate degradation" EXACT [] is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009441 name: glycolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732] synonym: "glycolate metabolism" EXACT [] xref: MetaCyc:GLYCOLATEMET-PWY is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0009442 name: allantoin assimilation pathway namespace: biological_process def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] synonym: "allantoin catabolism via ureidoglycolate" EXACT [] synonym: "allantoin degradation pathway" RELATED [] xref: MetaCyc:PWY0-41 is_a: GO:0000256 ! allantoin catabolic process [Term] id: GO:0009443 name: pyridoxal 5'-phosphate salvage namespace: biological_process def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] synonym: "pyridoxal 5' phosphate salvage" EXACT [] xref: MetaCyc:PLPSAL-PWY is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009444 name: pyruvate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY] xref: MetaCyc:PYRUVOX-PWY xref: Wikipedia:Pyruvate_decarboxylation is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0009445 name: putrescine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] synonym: "putrescine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0009446 name: putrescine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732] synonym: "putrescine anabolism" EXACT [] synonym: "putrescine biosynthesis" EXACT [] synonym: "putrescine formation" EXACT [] synonym: "putrescine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009447 name: putrescine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] synonym: "putrescine breakdown" EXACT [] synonym: "putrescine catabolism" EXACT [] synonym: "putrescine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0009451 name: RNA modification namespace: biological_process alt_id: GO:0016547 def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. subset: goslim_yeast synonym: "RNA editing" NARROW [GOC:hjd] xref: Wikipedia:RNA_editing is_a: GO:0016070 ! RNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0009452 name: 7-methylguanosine RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent transcript." [GOC:vw, PMID:9266685] synonym: "m(7)G RNA capping" EXACT [GOC:bf, GOC:krc, GOC:mah] synonym: "RNA capping" BROAD [GOC:krc, GOC:mah] is_a: GO:0036260 ! RNA capping [Term] id: GO:0009453 name: energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] synonym: "energytaxis" EXACT [] synonym: "taxis in response to energy source" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0009454 name: aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] synonym: "taxis in response to atmospheric oxygen" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0009455 name: redox taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] synonym: "redoxtaxis" EXACT [] synonym: "taxis in response to redox potential" EXACT [] synonym: "taxis in response to redox stimulus" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis is_a: GO:0051775 ! response to redox state [Term] id: GO:0009457 name: obsolete flavodoxin namespace: molecular_function def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] comment: This term was made obsolete because it represents a class of gene products. synonym: "flavodoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009458 name: obsolete cytochrome namespace: molecular_function def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome" EXACT [] is_obsolete: true consider: GO:0045153 consider: GO:0045154 consider: GO:0045155 consider: GO:0045156 consider: GO:0045157 consider: GO:0045158 [Term] id: GO:0009459 name: obsolete cytochrome a namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome a" EXACT [] is_obsolete: true replaced_by: GO:0045154 [Term] id: GO:0009460 name: obsolete cytochrome b namespace: molecular_function def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009461 name: obsolete cytochrome c namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c" EXACT [] is_obsolete: true replaced_by: GO:0045155 [Term] id: GO:0009462 name: obsolete cytochrome d namespace: molecular_function def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome d" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009463 name: obsolete cytochrome b/b6 namespace: molecular_function def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b/b6" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009464 name: obsolete cytochrome b5 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b5" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009465 name: obsolete soluble cytochrome b562 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "soluble cytochrome b562" EXACT [] is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009466 name: obsolete class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009467 name: obsolete monoheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "monoheme class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009468 name: obsolete diheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "diheme class I cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009469 name: obsolete class II cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class II cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009470 name: obsolete class IIa cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IIa cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009471 name: obsolete class III cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class III cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009472 name: obsolete cytochrome c3 (tetraheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c3 (tetraheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009473 name: obsolete cytochrome c7 (triheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c7 (triheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009474 name: obsolete nonaheme cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "nonaheme cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009475 name: obsolete high-molecular-weight cytochrome c (hexadecaheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "high-molecular-weight cytochrome c (hexadecaheme)" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009476 name: obsolete class IV cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IV cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009477 name: obsolete cytochrome c1 namespace: molecular_function def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c1" EXACT [] is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009478 name: obsolete cytochrome c554 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome c554" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009479 name: obsolete cytochrome f namespace: molecular_function def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome f" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009480 name: obsolete class IIb cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "class IIb cytochrome c" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0009481 name: obsolete aa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "aa3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009482 name: obsolete ba3-type cytochrome c oxidase namespace: molecular_function alt_id: GO:0009484 def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "ba3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009483 name: obsolete caa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "caa3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009485 name: obsolete cbb3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. synonym: "cbb3-type cytochrome c oxidase" EXACT [] is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009486 name: cytochrome bo3 ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ubiquinol + O2 + 4 H+ = 2 ubiquinone + 2 H2O + 4 H+ [periplasmic space]." [MetaCyc:RXN0-5268] xref: EC:1.10.3 xref: MetaCyc:RXN0-5268 is_a: GO:0015002 ! heme-copper terminal oxidase activity [Term] id: GO:0009487 name: obsolete glutaredoxin namespace: molecular_function def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] comment: This term was made obsolete because it represents a gene product. synonym: "glutaredoxin" EXACT [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 consider: GO:0015038 [Term] id: GO:0009488 name: obsolete amicyanin namespace: molecular_function def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] comment: This term was made obsolete because it does not represent a molecular function. synonym: "amicyanin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009489 name: obsolete rubredoxin namespace: molecular_function def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] comment: This term was made obsolete because it does not represent a molecular function. synonym: "rubredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009490 name: obsolete mononuclear iron electron carrier namespace: molecular_function def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mononuclear iron electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009491 name: obsolete redox-active disulfide bond electron carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "redox-active disulfide bond electron carrier" EXACT [] synonym: "redox-active disulphide bond electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009492 name: obsolete 2Fe-2S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "2Fe-2S electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009493 name: obsolete adrenodoxin-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "adrenodoxin-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009494 name: obsolete chloroplast-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "chloroplast-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009495 name: obsolete thioredoxin-like 2Fe-2S ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "thioredoxin-like 2Fe-2S ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009496 name: plastoquinol--plastocyanin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 H(+)[side 1] + 2 oxidized plastocyanin + plastoquinol-1 = 2 H(+)[side 2] + 2 reduced plastocyanin + plastoquinone. This reaction involves the concomitant transfer of 2 H+ ions across a membrane." [EC:1.10.9.1] synonym: "cytochrome b6-f complex activity" RELATED [EC:1.10.9.1] synonym: "cytochrome b6/f complex activity" RELATED [EC:1.10.9.1] synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] synonym: "cytochrome b6f complex activity" RELATED [EC:1.10.9.1] synonym: "plastoquinol-plastocyanin reductase activity" EXACT [EC:1.10.9.1] synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] xref: EC:1.10.9.1 xref: KEGG:R03817 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN is_a: GO:0052880 ! oxidoreductase activity, acting on diphenols and related substances as donors, with copper protein as acceptor [Term] id: GO:0009497 name: obsolete 3Fe-4S/4Fe-4S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "3Fe-4S/4Fe-4S electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009498 name: obsolete bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009499 name: obsolete monocluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "monocluster bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009500 name: obsolete dicluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "dicluster bacterial-type ferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009501 name: amyloplast namespace: cellular_component def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] xref: Wikipedia:Amyloplast is_a: GO:0009536 ! plastid [Term] id: GO:0009502 name: obsolete photosynthetic electron transport chain namespace: cellular_component def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403] comment: This term was made obsolete because it represents a process. synonym: "photosynthetic electron transport chain" EXACT [] is_obsolete: true consider: GO:0009767 [Term] id: GO:0009503 name: thylakoid light-harvesting complex namespace: cellular_component def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0030076 ! light-harvesting complex is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex [Term] id: GO:0009504 name: cell plate namespace: cellular_component def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] xref: Wikipedia:Cell_plate is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009505 name: plant-type cell wall namespace: cellular_component def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208] synonym: "cellulose and pectin-containing cell wall" EXACT [] synonym: "plant cell wall" NARROW [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009506 name: plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732] synonym: "plasmodesmata" EXACT [] xref: Wikipedia:Plasmodesma is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0055044 ! symplast [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] subset: goslim_plant xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999] is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044435 ! plastid part relationship: part_of GO:0042646 ! plastid nucleoid [Term] id: GO:0009509 name: chromoplast namespace: cellular_component def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] xref: Wikipedia:Chromoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009510 name: plasmodesmatal desmotubule namespace: cellular_component alt_id: GO:0009572 def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "desmotubule central rod" RELATED [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009511 name: plasmodesmatal endoplasmic reticulum namespace: cellular_component def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] synonym: "plasmodesmatal ER" EXACT [] is_a: GO:0005783 ! endoplasmic reticulum is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009510 ! plasmodesmatal desmotubule [Term] id: GO:0009512 name: cytochrome b6f complex namespace: cellular_component def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458] synonym: "cyt b(6)f complex" EXACT [] synonym: "cyt b6-f complex" EXACT [] synonym: "cyt b6/f complex" EXACT [] synonym: "cyt b6f complex" EXACT [] synonym: "cytochrome b(6)f complex" EXACT [] synonym: "cytochrome b6-f complex" EXACT [] synonym: "cytochrome b6/f complex" EXACT [] xref: Wikipedia:Cytochrome_b6f_complex is_a: GO:0044436 ! thylakoid part is_a: GO:0070069 ! cytochrome complex [Term] id: GO:0009513 name: etioplast namespace: cellular_component def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999] xref: Wikipedia:Etioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009514 name: glyoxysome namespace: cellular_component def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031] xref: Wikipedia:Glyoxysome is_a: GO:0005777 ! peroxisome [Term] id: GO:0009515 name: granal stacked thylakoid namespace: cellular_component def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] synonym: "chloroplast stacked thylakoid" EXACT [] is_a: GO:0009534 ! chloroplast thylakoid relationship: part_of GO:0009542 ! granum [Term] id: GO:0009516 name: leucoplast namespace: cellular_component def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999] xref: Wikipedia:Leucoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009517 name: PSII associated light-harvesting complex II namespace: cellular_component def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] synonym: "LHCII" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009518 name: PSI associated light-harvesting complex I namespace: cellular_component def: "Protein-pigment complex associated with photosystem I." [GOC:lr] synonym: "LHCI" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009519 name: middle lamella namespace: cellular_component def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] xref: Wikipedia:Middle_lamella is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0009521 name: photosystem namespace: cellular_component alt_id: GO:0030090 def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: goslim_pir synonym: "reaction center" NARROW [] synonym: "reaction centre" NARROW [] xref: Wikipedia:Photosystem is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0034357 ! photosynthetic membrane [Term] id: GO:0009522 name: photosystem I namespace: cellular_component def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] is_a: GO:0009521 ! photosystem [Term] id: GO:0009523 name: photosystem II namespace: cellular_component def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] xref: Wikipedia:Photosystem_II is_a: GO:0009521 ! photosystem [Term] id: GO:0009524 name: phragmoplast namespace: cellular_component def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] xref: Wikipedia:Phragmoplast is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009525 name: phragmosome namespace: cellular_component def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999] xref: Wikipedia:Phragmosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope is_a: GO:0044435 ! plastid part [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009528 name: plastid inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] is_a: GO:0019866 ! organelle inner membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009529 name: plastid intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] synonym: "plastid envelope lumen" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0009530 name: primary cell wall namespace: cellular_component def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, PMID:9442872] is_a: GO:0009505 ! plant-type cell wall [Term] id: GO:0009531 name: secondary cell wall namespace: cellular_component def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, ISBN:0943088399] xref: Wikipedia:Secondary_cell_wall is_a: GO:0009505 ! plant-type cell wall [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:047142520] is_a: GO:0044435 ! plastid part [Term] id: GO:0009533 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999] is_a: GO:0009534 ! chloroplast thylakoid relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009534 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943883999] is_a: GO:0031976 ! plastid thylakoid is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009535 name: chloroplast thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] is_a: GO:0044434 ! chloroplast part is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009537 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943883999] is_a: GO:0009536 ! plastid [Term] id: GO:0009538 name: photosystem I reaction center namespace: cellular_component def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] synonym: "photosystem I reaction centre" EXACT [] is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009539 name: photosystem II reaction center namespace: cellular_component def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] synonym: "photosystem II reaction centre" EXACT [] is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009540 name: zeaxanthin epoxidase [overall] activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O; and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] comment: This is a process composed of two reactions represented by the terms 'GO:0052662 : zeaxanthin epoxidase activity' and 'GO:0052663 : antheraxanthin epoxidase activity'. synonym: "zea-epoxidase activity" RELATED [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" RELATED [EC:1.14.13.90] xref: EC:1.14.13.90 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0009541 name: etioplast prolamellar body namespace: cellular_component def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] is_a: GO:0044435 ! plastid part relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009542 name: granum namespace: cellular_component def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403] is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009543 name: chloroplast thylakoid lumen namespace: cellular_component def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:006501037] is_a: GO:0031978 ! plastid thylakoid lumen is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009544 name: chloroplast ATP synthase complex namespace: cellular_component def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex [Term] id: GO:0009545 name: elaioplast namespace: cellular_component def: "A leucoplast in which oil is stored." [ISBN:0140514031] xref: Wikipedia:Elaioplast is_a: GO:0009516 ! leucoplast [Term] id: GO:0009546 name: plasmodesmatal cytoplasmic sleeve namespace: cellular_component def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome is_a: GO:0044435 ! plastid part relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0009548 name: plasmodesmatal plasma membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009549 name: cellulose microfibril namespace: cellular_component def: "A microfibril composed of cellulose arranged in orthogonal layers. Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, ISBN:0943088399] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009505 ! plant-type cell wall [Term] id: GO:0009550 name: primary plasmodesma namespace: cellular_component def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] synonym: "simple plasmodesma" EXACT [] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009551 name: secondary plasmodesma namespace: cellular_component def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009553 name: embryo sac development namespace: biological_process alt_id: GO:0048230 def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] synonym: "female gametophyte development" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009554 name: megasporogenesis namespace: biological_process def: "The process in which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] synonym: "megaspore development" EXACT [] synonym: "megaspore mother cell meiosis" EXACT [] synonym: "meiosis of the megasporocyte" EXACT [] synonym: "meiotic division of the megasporocyte" EXACT [] is_a: GO:0048236 ! plant-type sporogenesis relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009555 name: pollen development namespace: biological_process alt_id: GO:0009564 alt_id: GO:0048231 def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] synonym: "formation of generative and vegetative cells" EXACT [] synonym: "male gametophyte development" EXACT [] synonym: "male gametophyte formation" EXACT [] synonym: "microgametophyte development" EXACT [] synonym: "pollen grain formation" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009556 name: microsporogenesis namespace: biological_process def: "The process in which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] synonym: "microspore development" EXACT systematic_synonym [] is_a: GO:0048236 ! plant-type sporogenesis relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0009557 name: antipodal cell differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009558 name: embryo sac cellularization namespace: biological_process alt_id: GO:0009797 def: "The process in which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] synonym: "cellularization of the embryo sac" EXACT [GOC:curators] synonym: "female gametophyte cellularization" EXACT [] synonym: "megagametophyte cellularization" EXACT [] is_a: GO:0007349 ! cellularization relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009559 name: embryo sac central cell differentiation namespace: biological_process def: "The process in which the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant] synonym: "embryo sac endosperm mother cell differentiation" EXACT [] synonym: "female gametophyte central cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009560 name: embryo sac egg cell differentiation namespace: biological_process alt_id: GO:0048233 def: "The process in which an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu] synonym: "female gamete generation" BROAD [] synonym: "female gametophyte egg cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007292 ! female gamete generation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009561 name: megagametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] synonym: "megagametophyte nucleus division" EXACT [] xref: Wikipedia:Megagametogenesis is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009562 name: embryo sac nuclear migration namespace: biological_process def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac nucleus migration" EXACT [] synonym: "female gametophyte nuclear migration" EXACT [] synonym: "female gametophyte nucleus migration" EXACT [] synonym: "megagametophyte nuclear migration" EXACT [] synonym: "megagametophyte nucleus migration" EXACT [] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009563 name: synergid differentiation namespace: biological_process def: "The process in which an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid] synonym: "synergid cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732] synonym: "syngamy" EXACT [] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009567 name: double fertilization forming a zygote and endosperm namespace: biological_process def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "double fertilization" EXACT [] is_a: GO:0009566 ! fertilization [Term] id: GO:0009568 name: amyloplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "amyloplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0009569 name: chloroplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732] synonym: "chloroplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009571 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009537 ! proplastid [Term] id: GO:0009573 name: chloroplast ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu] synonym: "chloroplast RubisCO complex" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009574 name: preprophase band namespace: cellular_component def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732] xref: Wikipedia:Preprophase_band is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0009575 name: chromoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0009576 name: leucoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009516 ! leucoplast [Term] id: GO:0009577 name: elaioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009545 ! elaioplast [Term] id: GO:0009578 name: etioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0044424 ! intracellular part [Term] id: GO:0009580 name: obsolete thylakoid (sensu Bacteria) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific children exist. synonym: "thylakoid (sensu Bacteria)" EXACT [] is_obsolete: true consider: GO:0030075 consider: GO:0042716 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009585 name: red, far-red light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction relationship: part_of GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0009587 name: obsolete phototrophin mediated phototransduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] synonym: "phototrophin mediated phototransduction" EXACT [] is_obsolete: true replaced_by: GO:0007602 [Term] id: GO:0009588 name: UV-A, blue light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of 315 to 400 nm." [GOC:mah] synonym: "blue-sensitive opsin" RELATED [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:dos, GOC:go_curators, GOC:hb, ISBN:0198506732] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity namespace: biological_process def: "The series of events in which a gravitational stimulus is received and converted into a molecular signal." [GOC:dos, GOC:hb] synonym: "perception of gravity" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009591 name: obsolete perception of mechanical stimulus namespace: biological_process alt_id: GO:0007609 def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. synonym: "perception of mechanical stimulus" EXACT [] is_obsolete: true consider: GO:0050954 [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "chemoreception" RELATED [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0051606 ! detection of stimulus relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0009594 name: detection of nutrient namespace: biological_process def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "detection of nutrients" EXACT [] synonym: "nutrient sensing" RELATED [] synonym: "perception of nutrients" RELATED [] is_a: GO:0007584 ! response to nutrient is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009595 name: detection of biotic stimulus namespace: biological_process alt_id: GO:0009596 def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] synonym: "perception of biotic stimulus" RELATED [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009597 name: detection of virus namespace: biological_process def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] comment: GO:0009597 is not a child term of 'detection of symbiont ; GO:0009602' to allow annotation of a virus responding to another (often competing) virus. synonym: "perception of virus" RELATED [] is_a: GO:0009615 ! response to virus [Term] id: GO:0009600 name: detection of nematode namespace: biological_process def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] synonym: "perception of nematode" RELATED [] is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009601 name: detection of insect namespace: biological_process def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] synonym: "perception of insect" RELATED [] is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009602 name: detection of symbiont namespace: biological_process def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] synonym: "perception of symbiont" RELATED [] is_a: GO:0009608 ! response to symbiont is_a: GO:0098543 ! detection of other organism [Term] id: GO:0009603 name: detection of symbiotic fungus namespace: biological_process def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] synonym: "detection of symbiotic fungi" EXACT [] synonym: "perception of symbiotic fungi" RELATED [] synonym: "perception of symbiotic fungus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009610 ! response to symbiotic fungus is_a: GO:0016046 ! detection of fungus [Term] id: GO:0009604 name: detection of symbiotic bacterium namespace: biological_process def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] synonym: "detection of symbiotic bacteria" EXACT [] synonym: "perception of symbiotic bacteria" RELATED [] synonym: "perception of symbiotic bacterium" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009609 ! response to symbiotic bacterium is_a: GO:0016045 ! detection of bacterium [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009606 name: tropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:curators, ISBN:0877795088] subset: goslim_plant xref: Wikipedia:Tropism is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009608 name: response to symbiont namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732] synonym: "response of host to symbiont" RELATED [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009609 name: response to symbiotic bacterium namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732] synonym: "response to symbiotic bacteria" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009617 ! response to bacterium [Term] id: GO:0009610 name: response to symbiotic fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732] synonym: "response to symbiotic fungi" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009620 ! response to fungus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009614 name: obsolete disease resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "disease resistance" EXACT [] is_obsolete: true replaced_by: GO:0051707 [Term] id: GO:0009615 name: response to virus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] synonym: "response to viruses" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009616 name: virus induced gene silencing namespace: biological_process def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl] comment: Virus-induced gene silencing (VIGS) is a RNA-mediated post-transcriptional gene silencing mechanism that protects plants against foreign gene invasion. synonym: "VIGS" EXACT [] synonym: "virus-induced gene silencing" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051607 ! defense response to virus is_a: GO:0052018 ! modulation by symbiont of RNA levels in host is_a: GO:0098586 ! cellular response to virus [Term] id: GO:0009617 name: response to bacterium namespace: biological_process alt_id: GO:0009618 alt_id: GO:0009680 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] synonym: "response to bacteria" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009619 name: obsolete resistance to pathogenic bacteria namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic bacteria" EXACT [] is_obsolete: true replaced_by: GO:0009617 [Term] id: GO:0009620 name: response to fungus namespace: biological_process alt_id: GO:0009621 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009622 name: obsolete resistance to pathogenic fungi namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "resistance to pathogenic fungi" EXACT [] is_obsolete: true replaced_by: GO:0009620 [Term] id: GO:0009623 name: response to parasitic fungus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732] synonym: "response to parasitic fungi" EXACT [] is_a: GO:0009610 ! response to symbiotic fungus [Term] id: GO:0009624 name: response to nematode namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] synonym: "response to nematodes" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009625 name: response to insect namespace: biological_process alt_id: GO:0043019 def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] synonym: "response to insects" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. synonym: "HR" EXACT [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! host programmed cell death induced by symbiont is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0045087 ! innate immune response [Term] id: GO:0009627 name: systemic acquired resistance namespace: biological_process def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641] synonym: "salicylic acid-dependent systemic resistance" EXACT [] xref: Wikipedia:Systemic_acquired_resistance is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (not derived from living organisms) stimulus." [GOC:hb] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. Changed definition as requested in https://github.com/geneontology/go-ontology/issues/16572. subset: gocheck_do_not_manually_annotate subset: goslim_metagenomics subset: goslim_plant synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] synonym: "response to gravitational stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009630 name: gravitropism namespace: biological_process def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] synonym: "geotropism" EXACT [] xref: Wikipedia:Gravitropism is_a: GO:0009606 ! tropism is_a: GO:0009629 ! response to gravity [Term] id: GO:0009631 name: cold acclimation namespace: biological_process def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] is_a: GO:0009409 ! response to cold [Term] id: GO:0009632 name: obsolete freezing tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. synonym: "freezing tolerance" EXACT [] is_obsolete: true consider: GO:0009409 [Term] id: GO:0009633 name: obsolete drought tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. synonym: "drought tolerance" EXACT [] is_obsolete: true consider: GO:0009414 consider: GO:0009819 [Term] id: GO:0009634 name: obsolete heavy metal sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "heavy metal sensitivity/resistance" EXACT [] is_obsolete: true consider: GO:0010038 [Term] id: GO:0009635 name: response to herbicide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [GOC:curators] synonym: "herbicide susceptibility/resistance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0009636 name: response to toxic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus." [GOC:lr] subset: goslim_chembl synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical [Term] id: GO:0009637 name: response to blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] synonym: "response to blue light stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009638 name: phototropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, PMID:16870491] xref: Wikipedia:Phototropism is_a: GO:0009606 ! tropism is_a: GO:0009637 ! response to blue light [Term] id: GO:0009639 name: response to red or far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009640 name: photomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] synonym: "plant development in response to light" EXACT systematic_synonym [] xref: Wikipedia:Photomorphogenesis is_a: GO:0009639 ! response to red or far red light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009641 name: shade avoidance namespace: biological_process def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance] xref: Wikipedia:Shade_avoidance is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0009642 name: response to light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009643 name: photosynthetic acclimation namespace: biological_process def: "A response to light intensity in which exposure to medium-intensity light results in increased tolerance to high-intensity light." [GOC:mah, PMID:11069694] synonym: "light acclimatization" EXACT [PMID:11069694] synonym: "photoacclimation" EXACT [GOC:tb] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009644 name: response to high light intensity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009645 name: response to low light intensity stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009646 name: response to absence of light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] synonym: "response to darkness" RELATED [] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009647 name: skotomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] synonym: "etiolation" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009648 name: photoperiodism namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to day length" EXACT [] synonym: "response to night length" EXACT [] synonym: "response to photoperiod" EXACT [] xref: Wikipedia:Photoperiodism is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009649 name: entrainment of circadian clock namespace: biological_process def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] synonym: "regulation of circadian rhythm phase" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0009650 name: UV protection namespace: biological_process def: "Any process in which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] synonym: "ultraviolet protection" EXACT [] synonym: "ultraviolet resistance" RELATED [] synonym: "ultraviolet tolerance" RELATED [] synonym: "UV resistance" RELATED [] synonym: "UV tolerance" RELATED [] is_a: GO:0009411 ! response to UV [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0009652 name: thigmotropism namespace: biological_process def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, PMID:16153165] xref: Wikipedia:Thigmotropism is_a: GO:0009606 ! tropism is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] subset: goslim_plant synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009654 name: photosystem II oxygen evolving complex namespace: cellular_component def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [GOC:cjm, InterPro:IPR002683] synonym: "OEC (PSII) complex" EXACT [GOC:cjm] synonym: "oxygen evolving complex" EXACT [GOC:cjm] xref: Wikipedia:Oxygen_evolving_complex is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990204 ! oxidoreductase complex relationship: part_of GO:0009523 ! photosystem II relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0009655 name: PSII associated light-harvesting complex II, core complex namespace: cellular_component def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009656 name: PSII associated light-harvesting complex II, peripheral complex namespace: cellular_component def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [GOC:curators] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [GOC:curators] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009659 name: leucoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid] synonym: "leucoplast organisation" EXACT [GOC:curators] synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009660 name: amyloplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid] synonym: "amyloplast organisation" EXACT [GOC:curators] synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009661 name: chromoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid] synonym: "chromoplast organisation" EXACT [GOC:curators] synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009662 name: etioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid] synonym: "etioplast organisation" EXACT [GOC:curators] synonym: "etioplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009663 name: plasmodesma organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah] synonym: "plasmodesma organisation" EXACT [GOC:curators] synonym: "plasmodesma organization and biogenesis" RELATED [GOC:curators] synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0009664 name: plant-type cell wall organization namespace: biological_process def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] synonym: "cell wall organization and biogenesis" NARROW [] synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "plant-type cell wall organisation" EXACT [GOC:curators] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071555 ! cell wall organization is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [GOC:curators] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009667 name: plastid inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid inner membrane organisation" EXACT [GOC:curators] synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [GOC:curators] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0009669 name: sucrose:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] synonym: "sucrose permease activity" RELATED [] synonym: "sucrose:monovalent cation symporter activity" EXACT [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0008515 ! sucrose transmembrane transporter activity [Term] id: GO:0009670 name: triose-phosphate:phosphate antiporter activity namespace: molecular_function alt_id: GO:0015122 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] synonym: "TPT" RELATED [] synonym: "triose phosphate antiporter" EXACT [] synonym: "triose phosphate translocator" EXACT [] is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0071917 ! triose-phosphate transmembrane transporter activity [Term] id: GO:0009671 name: nitrate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981] synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] synonym: "nitrate(chlorate):proton symporter activity" EXACT [] synonym: "nitrate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity [Term] id: GO:0009672 name: auxin:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] synonym: "auxin:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0009673 name: low-affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] synonym: "low affinity phosphate transmembrane transporter activity" EXACT [] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity [Term] id: GO:0009674 name: potassium:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0009675 name: high-affinity sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity sulfate:hydrogen symporter activity" EXACT [] synonym: "high affinity sulfate:proton symporter activity" EXACT [] synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:proton symporter activity [Term] id: GO:0009676 name: low-affinity sulfate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135] synonym: "low affinity sulfate:hydrogen symporter activity" EXACT [] synonym: "low affinity sulfate:proton symporter activity" EXACT [] synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:proton symporter activity [Term] id: GO:0009677 name: double fertilization forming two zygotes namespace: biological_process def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb] is_a: GO:0009566 ! fertilization [Term] id: GO:0009678 name: hydrogen-translocating pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-] synonym: "proton-translocating pyrophosphatase activity" EXACT [] is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0009679 name: hexose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] synonym: "hexose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0009682 name: induced systemic resistance namespace: biological_process def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] is_a: GO:0042742 ! defense response to bacterium is_a: GO:0045087 ! innate immune response [Term] id: GO:0009683 name: indoleacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] synonym: "IAA metabolic process" EXACT [] synonym: "indole acetic acid metabolic process" EXACT [] synonym: "indole acetic acid metabolism" EXACT [] synonym: "indoleacetic acid metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process [Term] id: GO:0009684 name: indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] synonym: "IAA biosynthetic process" EXACT [] synonym: "indole acetic acid biosynthesis" EXACT [] synonym: "indole acetic acid biosynthetic process" EXACT [] synonym: "indole-3-acetate biosynthesis" EXACT [] synonym: "indole-3-acetate biosynthetic process" EXACT [] synonym: "indole-acetic acid biosynthesis" EXACT [] synonym: "indole-acetic acid biosynthetic process" RELATED [] synonym: "indoleacetic acid anabolism" EXACT [] synonym: "indoleacetic acid biosynthesis" EXACT [] synonym: "indoleacetic acid formation" EXACT [] synonym: "indoleacetic acid synthesis" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009685 name: gibberellin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] synonym: "gibberellic acid metabolic process" NARROW [] synonym: "gibberellic acid metabolism" NARROW [] synonym: "gibberellin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009686 name: gibberellin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] synonym: "gibberellic acid anabolism" NARROW [] synonym: "gibberellic acid biosynthesis" NARROW [] synonym: "gibberellic acid biosynthetic process" NARROW [] synonym: "gibberellic acid formation" NARROW [] synonym: "gibberellic acid synthesis" NARROW [] synonym: "gibberellin biosynthesis" EXACT [] xref: MetaCyc:PWY-5035 xref: MetaCyc:PWY-5036 xref: MetaCyc:PWY-5052 xref: MetaCyc:PWY-5070 is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009687 name: abscisic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] synonym: "abscisic acid metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043288 ! apocarotenoid metabolic process is_a: GO:1902644 ! tertiary alcohol metabolic process [Term] id: GO:0009688 name: abscisic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] synonym: "abscisic acid anabolism" EXACT [] synonym: "abscisic acid biosynthesis" EXACT [] synonym: "abscisic acid formation" EXACT [] synonym: "abscisic acid synthesis" EXACT [] xref: MetaCyc:PWY-695 is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0009689 name: induction of phytoalexin biosynthetic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] synonym: "induction of phytoalexin anabolism" EXACT [] synonym: "induction of phytoalexin biosynthesis" EXACT [] synonym: "induction of phytoalexin formation" EXACT [] synonym: "induction of phytoalexin synthesis" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: goslim_chembl synonym: "cytokinin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009691 name: cytokinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] synonym: "cytokinin anabolism" EXACT [] synonym: "cytokinin biosynthesis" EXACT [] synonym: "cytokinin formation" EXACT [] synonym: "cytokinin synthesis" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009692 name: ethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] synonym: "ethene metabolic process" EXACT [] synonym: "ethene metabolism" EXACT [] synonym: "ethylene metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0009693 name: ethylene biosynthetic process namespace: biological_process alt_id: GO:0042456 def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] synonym: "ethene biosynthesis" EXACT [] synonym: "ethene biosynthesis from L-methionine" EXACT [] synonym: "ethene biosynthetic process" EXACT [] synonym: "ethene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene anabolism" EXACT [] synonym: "ethylene biosynthesis" EXACT [] synonym: "ethylene biosynthesis from L-methionine" EXACT [] synonym: "ethylene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene formation" EXACT [] synonym: "ethylene synthesis" EXACT [] xref: MetaCyc:ETHYL-PWY is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009694 name: jasmonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] synonym: "jasmonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0009695 name: jasmonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] synonym: "jasmonic acid anabolism" EXACT [] synonym: "jasmonic acid biosynthesis" EXACT [] synonym: "jasmonic acid formation" EXACT [] synonym: "jasmonic acid synthesis" EXACT [] xref: MetaCyc:PWY-735 is_a: GO:0009694 ! jasmonic acid metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009696 name: salicylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] synonym: "salicylic acid metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042445 ! hormone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0009697 name: salicylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] synonym: "salicylate biosynthetic process" EXACT [] synonym: "salicylic acid anabolism" EXACT [] synonym: "salicylic acid biosynthesis" EXACT [] synonym: "salicylic acid formation" EXACT [] synonym: "salicylic acid synthesis" EXACT [] xref: MetaCyc:PWY-981 is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009698 name: phenylpropanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] synonym: "phenylpropanoid metabolism" EXACT [] xref: MetaCyc:PWY1F-467 is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009699 name: phenylpropanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] synonym: "phenylpropanoid anabolism" EXACT [] synonym: "phenylpropanoid biosynthesis" EXACT [] synonym: "phenylpropanoid formation" EXACT [] synonym: "phenylpropanoid synthesis" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009700 name: indole phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] synonym: "indole phytoalexin anabolism" EXACT [] synonym: "indole phytoalexin biosynthesis" EXACT [] synonym: "indole phytoalexin formation" EXACT [] synonym: "indole phytoalexin synthesis" EXACT [] is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009701 name: isoflavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin anabolism" EXACT [] synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] synonym: "isoflavonoid phytoalexin formation" EXACT [] synonym: "isoflavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009717 ! isoflavonoid biosynthetic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009702 name: L-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose + ATP = beta-L-arabinose 1-phosphate + ADP + 2 H(+)." [EC:2.7.1.46, RHEA:20153] synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] xref: EC:2.7.1.46 xref: KEGG:R01754 xref: MetaCyc:L-ARABINOKINASE-RXN xref: RHEA:20153 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009703 name: nitrate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: nitrite + NAD+ + H2O = nitrate + NADH + H+." [EC:1.7.1.1] comment: Note that this function was formerly EC:1.6.6.1. synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate reductase activity" EXACT [] synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] xref: EC:1.7.1.1 xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN xref: RHEA:17913 is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0009704 name: de-etiolation namespace: biological_process def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] is_a: GO:0009416 ! response to light stimulus relationship: part_of GO:0009640 ! photomorphogenesis [Term] id: GO:0009705 name: plant-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208] synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] synonym: "tonoplast" EXACT [] synonym: "vacuolar membrane" BROAD [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0009706 name: chloroplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] synonym: "chloroplast inner envelope" EXACT [] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009708 name: benzyl isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732] synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] synonym: "benzyl isoquinoline alkaloid formation" EXACT [] synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process [Term] id: GO:0009709 name: terpenoid indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] synonym: "terpenoid indole alkaloid anabolism" EXACT [] synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] synonym: "terpenoid indole alkaloid formation" EXACT [] synonym: "terpenoid indole alkaloid synthesis" EXACT [] is_a: GO:0035835 ! indole alkaloid biosynthetic process is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process [Term] id: GO:0009710 name: tropane alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732] synonym: "tropane alkaloid anabolism" EXACT [] synonym: "tropane alkaloid biosynthesis" EXACT [] synonym: "tropane alkaloid formation" EXACT [] synonym: "tropane alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046448 ! tropane alkaloid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009711 name: purine alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] synonym: "purine alkaloid anabolism" EXACT [] synonym: "purine alkaloid biosynthesis" EXACT [] synonym: "purine alkaloid formation" EXACT [] synonym: "purine alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0046446 ! purine alkaloid metabolic process is_a: GO:0072522 ! purine-containing compound biosynthetic process [Term] id: GO:0009712 name: catechol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] synonym: "catechol metabolic process" RELATED [] synonym: "catechol metabolism" RELATED [] is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0009713 name: catechol-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol anabolism" RELATED [] synonym: "catechol biosynthesis" RELATED [] synonym: "catechol biosynthetic process" RELATED [] synonym: "catechol formation" RELATED [] synonym: "catechol synthesis" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0009714 name: chalcone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732] synonym: "chalcone metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009715 name: chalcone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] synonym: "chalcone anabolism" EXACT [] synonym: "chalcone biosynthesis" EXACT [] synonym: "chalcone formation" EXACT [] synonym: "chalcone synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0009716 name: flavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732] synonym: "flavonoid phytoalexin anabolism" EXACT [] synonym: "flavonoid phytoalexin biosynthesis" EXACT [] synonym: "flavonoid phytoalexin formation" EXACT [] synonym: "flavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009717 name: isoflavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] synonym: "isoflavonoid anabolism" EXACT [] synonym: "isoflavonoid biosynthesis" EXACT [] synonym: "isoflavonoid formation" EXACT [] synonym: "isoflavonoid synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046287 ! isoflavonoid metabolic process [Term] id: GO:0009718 name: anthocyanin-containing compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] synonym: "anthocyanin anabolism" EXACT [] synonym: "anthocyanin biosynthesis" EXACT [] synonym: "anthocyanin biosynthetic process" EXACT [] synonym: "anthocyanin formation" EXACT [] synonym: "anthocyanin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate subset: goslim_plant is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009720 name: detection of hormone stimulus namespace: biological_process def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of hormone stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009725 ! response to hormone is_a: GO:0009726 ! detection of endogenous stimulus [Term] id: GO:0009721 name: detection of auxin stimulus namespace: biological_process def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of auxin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009733 ! response to auxin [Term] id: GO:0009722 name: detection of cytokinin stimulus namespace: biological_process def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of cytokinin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009735 ! response to cytokinin [Term] id: GO:0009723 name: response to ethylene namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] synonym: "response to ethene stimulus" EXACT [] synonym: "response to ethylene stimulus" EXACT [] is_a: GO:0009725 ! response to hormone [Term] id: GO:0009724 name: detection of abscisic acid stimulus namespace: biological_process def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of abscisic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009737 ! response to abscisic acid [Term] id: GO:0009725 name: response to hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] synonym: "response to hormone stimulus" EXACT [GOC:dos] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009726 name: detection of endogenous stimulus namespace: biological_process def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of endogenous stimulus" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009727 name: detection of ethylene stimulus namespace: biological_process def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "detection of ethene stimulus" EXACT [] synonym: "perception of ethene stimulus" RELATED [] synonym: "perception of ethylene stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009723 ! response to ethylene [Term] id: GO:0009728 name: detection of gibberellic acid stimulus namespace: biological_process def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of gibberellic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009739 ! response to gibberellin [Term] id: GO:0009729 name: detection of brassinosteroid stimulus namespace: biological_process def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of brassinosteroid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009741 ! response to brassinosteroid [Term] id: GO:0009730 name: detection of carbohydrate stimulus namespace: biological_process def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of carbohydrate stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0009731 name: detection of sucrose stimulus namespace: biological_process def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of sucrose stimulus" RELATED [] is_a: GO:0009744 ! response to sucrose is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0009732 name: detection of hexose stimulus namespace: biological_process def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] synonym: "perception of hexose stimulus" RELATED [] is_a: GO:0009746 ! response to hexose is_a: GO:0034287 ! detection of monosaccharide stimulus [Term] id: GO:0009733 name: response to auxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] synonym: "response to auxin stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone [Term] id: GO:0009734 name: auxin-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of the plant hormone auxin to a receptor, and ending with modulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:sm, PMID:16990790, PMID:18647826] synonym: "auxin mediated signaling pathway" RELATED [] synonym: "auxin mediated signalling" EXACT [] synonym: "auxin signal transduction" EXACT [PMID:16990790] synonym: "auxin signaling" EXACT [PMID:18647826] synonym: "auxin-regulated transcription" RELATED [PMID:15917797] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071365 ! cellular response to auxin stimulus [Term] id: GO:0009735 name: response to cytokinin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] synonym: "response to cytokinin stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone [Term] id: GO:0009736 name: cytokinin-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of a cytokinin to a receptor, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:sm, PMID:24080474] synonym: "cytokinin mediated signaling pathway" RELATED [] synonym: "cytokinin mediated signalling" EXACT [] synonym: "cytokinin signaling" EXACT [PMID:24080474] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071368 ! cellular response to cytokinin stimulus [Term] id: GO:0009737 name: response to abscisic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] synonym: "response to abscisic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:0097305 ! response to alcohol [Term] id: GO:0009738 name: abscisic acid-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the binding of the plant hormone abscisic acid (ABA) to a receptor, and ending with modulation of a cellular process, e.g. transcription." [GOC:signaling, GOC:sm, PMID:24269821] synonym: "ABA signal transduction" EXACT [PMID:20713515] synonym: "ABA signaling" EXACT [PMID:24269821] synonym: "abscisic acid mediated signalling" EXACT [] synonym: "abscisic acid signal transduction" RELATED [PMID:20713515] synonym: "abscisic acid-mediated signaling pathway" RELATED [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071215 ! cellular response to abscisic acid stimulus [Term] id: GO:0009739 name: response to gibberellin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] synonym: "response to gibberellic acid stimulus" NARROW [] synonym: "response to gibberellin stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009740 name: gibberellic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] synonym: "GA-signaling" EXACT [] synonym: "gibberellic acid mediated signalling" EXACT [] synonym: "gibberellic acid signaling" EXACT [] is_a: GO:0010476 ! gibberellin mediated signaling pathway [Term] id: GO:0009741 name: response to brassinosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] synonym: "response to brassinosteroid stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009742 name: brassinosteroid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] synonym: "brassinosteroid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway relationship: part_of GO:0071367 ! cellular response to brassinosteroid stimulus [Term] id: GO:0009743 name: response to carbohydrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] synonym: "response to carbohydrate stimulus" EXACT [GOC:dos] is_a: GO:0010033 ! response to organic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009744 name: response to sucrose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] synonym: "response to sucrose stimulus" EXACT [GOC:dos] is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0009745 name: sucrose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] synonym: "sucrose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway relationship: part_of GO:0071329 ! cellular response to sucrose stimulus [Term] id: GO:0009746 name: response to hexose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] synonym: "response to hexose stimulus" EXACT [GOC:dos] is_a: GO:0034284 ! response to monosaccharide [Term] id: GO:0009747 name: hexokinase-dependent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-dependent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009748 name: hexokinase-independent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-independent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009749 name: response to glucose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] synonym: "response to glucose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0009750 name: response to fructose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] synonym: "response to fructose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0009751 name: response to salicylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] synonym: "response to salicylate" EXACT [GOC:dph] synonym: "response to salicylic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009752 name: detection of salicylic acid stimulus namespace: biological_process def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of salicylic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009751 ! response to salicylic acid [Term] id: GO:0009753 name: response to jasmonic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] synonym: "response to jasmonic acid stimulus" EXACT [GOC:dos] is_a: GO:0001101 ! response to acid chemical is_a: GO:0009725 ! response to hormone is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0009754 name: detection of jasmonic acid stimulus namespace: biological_process def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] synonym: "perception of jasmonic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009726 ! detection of endogenous stimulus is_a: GO:0009753 ! response to jasmonic acid [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0009756 name: carbohydrate mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] synonym: "carbohydrate mediated signalling" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0009757 name: hexose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] synonym: "hexose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway relationship: part_of GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0009758 name: carbohydrate utilization namespace: biological_process alt_id: GO:0007587 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mcc2, GOC:mlg] synonym: "sugar utilization" NARROW [GOC:mcc2] is_a: GO:0008150 ! biological_process [Term] id: GO:0009759 name: indole glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] synonym: "indole glucosinolate anabolism" EXACT [] synonym: "indole glucosinolate biosynthesis" EXACT [] synonym: "indole glucosinolate formation" EXACT [] synonym: "indole glucosinolate synthesis" EXACT [] xref: MetaCyc:PWY-601 is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process [Term] id: GO:0009760 name: C4 photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] xref: Wikipedia:C4_carbon_fixation is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009761 name: CAM photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] xref: Wikipedia:Crassulacean_acid_metabolism is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009762 name: NADP-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] xref: MetaCyc:PWY-241 is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009763 name: NAD-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009764 name: PEP carboxykinase C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009765 name: photosynthesis, light harvesting namespace: biological_process def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] synonym: "energy dissipation" RELATED [] is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009766 name: primary charge separation namespace: biological_process def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009767 name: photosynthetic electron transport chain namespace: biological_process alt_id: GO:0009774 alt_id: GO:0009775 alt_id: GO:0009776 def: "A process, occurring as part of photosynthesis, in which light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] synonym: "photosynthetic electron transport in cytochrome b6/f" NARROW [] synonym: "photosynthetic electron transport in plastocyanin" NARROW [] synonym: "photosynthetic electron transport in plastoquinone" NARROW [] is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009768 name: photosynthesis, light harvesting in photosystem I namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009769 name: photosynthesis, light harvesting in photosystem II namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009770 name: primary charge separation in photosystem I namespace: biological_process def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009771 name: primary charge separation in photosystem II namespace: biological_process def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009772 name: photosynthetic electron transport in photosystem II namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009773 name: photosynthetic electron transport in photosystem I namespace: biological_process def: "A photosynthetic electron transport chain in which electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009777 name: photosynthetic phosphorylation namespace: biological_process def: "Any metabolic process in which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] synonym: "photosynthetic ATP synthesis" NARROW [] is_a: GO:0016310 ! phosphorylation is_a: GO:0046034 ! ATP metabolic process relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009778 name: cyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009779 name: noncyclic photosynthetic phosphorylation namespace: biological_process def: "A photosynthetic phosphorylation process in which ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009780 name: photosynthetic NADP+ reduction namespace: biological_process def: "An NADPH regeneration process that contributes to the light reactions of photosynthesis. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360] is_a: GO:0006740 ! NADPH regeneration relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009781 name: obsolete photosynthetic water oxidation namespace: biological_process def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360] comment: This term was made obsolete because it represents a molecular function. synonym: "photosynthetic water oxidation" EXACT [] is_obsolete: true replaced_by: GO:0010242 [Term] id: GO:0009782 name: photosystem I antenna complex namespace: cellular_component def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009783 name: photosystem II antenna complex namespace: cellular_component def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009784 name: transmembrane receptor histidine kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of a membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0009785 name: blue light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] synonym: "blue light signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0071483 ! cellular response to blue light [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0009787 name: regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:1905957 ! regulation of cellular response to alcohol relationship: regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009788 name: negative regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "down regulation of abscisic acid mediated signaling" EXACT [] synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] synonym: "downregulation of abscisic acid mediated signaling" EXACT [] synonym: "inhibition of abscisic acid mediated signaling" NARROW [] synonym: "negative regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:1905958 ! negative regulation of cellular response to alcohol relationship: negatively_regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009789 name: positive regulation of abscisic acid-activated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of abscisic acid (ABA) signaling." [GOC:lr] synonym: "activation of abscisic acid mediated signaling" NARROW [] synonym: "positive regulation of abscisic acid mediated signaling pathway" RELATED [] synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] synonym: "stimulation of abscisic acid mediated signaling" NARROW [] synonym: "up regulation of abscisic acid mediated signaling" EXACT [] synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] synonym: "upregulation of abscisic acid mediated signaling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid-activated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:1905959 ! positive regulation of cellular response to alcohol relationship: positively_regulates GO:0009738 ! abscisic acid-activated signaling pathway [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: gocheck_do_not_manually_annotate subset: goslim_chembl subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0007275 ! multicellular organism development [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development [Term] id: GO:0009793 name: embryo development ending in seed dormancy namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009790 ! embryo development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009794 name: regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "embryonic mitotic cell cycle modulation" EXACT [] synonym: "embryonic mitotic cell cycle regulation" EXACT [] synonym: "embryonic mitotic cell cycle regulator" RELATED [] synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009799 name: specification of symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] synonym: "determination of symmetry" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009800 name: cinnamic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] synonym: "cinnamic acid anabolism" EXACT [] synonym: "cinnamic acid biosynthesis" EXACT [] synonym: "cinnamic acid formation" EXACT [] synonym: "cinnamic acid synthesis" EXACT [] synonym: "cinnamylic acid biosynthesis" EXACT [] synonym: "cinnamylic acid biosynthetic process" EXACT [] synonym: "phenylacrylic acid biosynthesis" EXACT [] synonym: "phenylacrylic acid biosynthetic process" EXACT [] synonym: "phenylpropenoic acid biosynthesis" EXACT [] synonym: "phenylpropenoic acid biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009803 ! cinnamic acid metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0009801 name: cinnamic acid ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] synonym: "cinnamic acid ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009802 name: cinnamic acid ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] synonym: "cinnamic acid ester anabolism" EXACT [] synonym: "cinnamic acid ester biosynthesis" EXACT [] synonym: "cinnamic acid ester formation" EXACT [] synonym: "cinnamic acid ester synthesis" EXACT [] synonym: "cinnamylic acid ester biosynthesis" EXACT [] synonym: "cinnamylic acid ester biosynthetic process" EXACT [] synonym: "phenylacrylic acid ester biosynthesis" EXACT [] synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009801 ! cinnamic acid ester metabolic process relationship: part_of GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009803 name: cinnamic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] synonym: "cinnamic acid metabolism" EXACT [] synonym: "cinnamylic acid metabolic process" EXACT [] synonym: "cinnamylic acid metabolism" EXACT [] synonym: "phenylacrylic acid metabolic process" EXACT [] synonym: "phenylacrylic acid metabolism" EXACT [] synonym: "phenylpropenoic acid metabolic process" EXACT [] synonym: "phenylpropenoic acid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0009804 name: coumarin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] synonym: "coumarin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009805 name: coumarin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] synonym: "coumarin anabolism" EXACT [] synonym: "coumarin biosynthesis" EXACT [] synonym: "coumarin formation" EXACT [] synonym: "coumarin synthesis" EXACT [] xref: MetaCyc:PWY-5176 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009804 ! coumarin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0009806 name: lignan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] synonym: "lignan metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009807 name: lignan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] synonym: "lignan anabolism" EXACT [] synonym: "lignan biosynthesis" EXACT [] synonym: "lignan formation" EXACT [] synonym: "lignan synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009806 ! lignan metabolic process [Term] id: GO:0009808 name: lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] synonym: "lignin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009809 name: lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] synonym: "lignin anabolism" EXACT [] synonym: "lignin biosynthesis" EXACT [] synonym: "lignin formation" EXACT [] synonym: "lignin synthesis" EXACT [] xref: MetaCyc:PWY-361 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009808 ! lignin metabolic process [Term] id: GO:0009810 name: stilbene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625] synonym: "stilbene metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0009811 name: stilbene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] synonym: "stilbene anabolism" EXACT [] synonym: "stilbene biosynthesis" EXACT [] synonym: "stilbene formation" EXACT [] synonym: "stilbene synthesis" EXACT [] is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:1900674 ! olefin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0009812 name: flavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] synonym: "flavonoid metabolism" EXACT [] is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0009813 name: flavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] synonym: "flavonoid anabolism" EXACT [] synonym: "flavonoid biosynthesis" EXACT [] synonym: "flavonoid formation" EXACT [] synonym: "flavonoid synthesis" EXACT [] xref: MetaCyc:PWY1F-FLAVSYN xref: Wikipedia:Flavonoid is_a: GO:0009812 ! flavonoid metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0009814 name: defense response, incompatible interaction namespace: biological_process def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response incompatible interaction" EXACT [] synonym: "defence response to pathogen, incompatible interaction" EXACT [] synonym: "resistance response to pathogen" EXACT [] synonym: "response to pathogen (incompatible interaction)" EXACT [] is_a: GO:0045087 ! innate immune response [Term] id: GO:0009815 name: 1-aminocyclopropane-1-carboxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + L-ascorbate + O(2) = CO(2) + dehydroascorbate + ethylene + 2 H(2)O + hydrogen cyanide. Ethene is also known as ethylene." [EC:1.14.17.4, RHEA:23640] synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] synonym: "ACC oxidase activity" EXACT [] synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] synonym: "ethene-forming enzyme" BROAD [] synonym: "ethylene-forming enzyme" BROAD [] xref: EC:1.14.17.4 xref: KEGG:R07214 xref: MetaCyc:ETHYL-RXN xref: RHEA:23640 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0009816 name: defense response to bacterium, incompatible interaction namespace: biological_process def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to bacterium, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic bacteria" EXACT [] synonym: "resistance response to pathogenic bacterium" EXACT [] synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT [] synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0009817 name: defense response to fungus, incompatible interaction namespace: biological_process def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to fungus, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT [] synonym: "defense response to fungi, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic fungi" EXACT [] synonym: "resistance response to pathogenic fungus" EXACT [] synonym: "response to pathogenic fungi (incompatible interaction)" EXACT [] synonym: "response to pathogenic fungus (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0009818 name: defense response to protozoan, incompatible interaction namespace: biological_process def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT [] synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT [] synonym: "defence response to protozoan, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic protozoa" EXACT [] synonym: "resistance response to pathogenic protozoan" EXACT [] synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT [] synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042832 ! defense response to protozoan [Term] id: GO:0009819 name: drought recovery namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] synonym: "drought tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: goslim_chembl synonym: "alkaloid metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0009822 name: alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743] synonym: "alkaloid breakdown" EXACT [] synonym: "alkaloid catabolism" EXACT [] synonym: "alkaloid degradation" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0009823 name: cytokinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] synonym: "cytokinin breakdown" EXACT [] synonym: "cytokinin catabolism" EXACT [] synonym: "cytokinin degradation" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009824 name: AMP dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + dimethylallyl diphosphate = N(6)-(dimethylallyl)adenosine 5'-phosphate + diphosphate." [EC:2.5.1.27, RHEA:15285] synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [KEGG:R04038] synonym: "adenylate dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "adenylate isopentenyltransferase activity" EXACT [] synonym: "cytokinin synthase activity" RELATED [] synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "isopentenyltransferase activity" BROAD [] xref: EC:2.5.1.27 xref: KEGG:R04038 xref: MetaCyc:RXN-4307 xref: RHEA:15285 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0009825 name: multidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] synonym: "cell growth in three dimensions" EXACT [] synonym: "cell growth in two dimensions" NARROW [] is_a: GO:0016049 ! cell growth [Term] id: GO:0009826 name: unidimensional cell growth namespace: biological_process def: "The process in which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] comment: Unidimensional cell growth refers to a change in both cell size and cell shape. For cell shape changes where cell size is not affected, consider instead the term 'regulation of cell shape ; GO:0008360' and its children. synonym: "cell elongation" NARROW [] synonym: "cell growth along one axis" EXACT [] synonym: "cell growth in one dimension" EXACT [] synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] synonym: "polar cell growth" EXACT [] synonym: "polarized cell growth" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0016049 ! cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0009827 name: plant-type cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall modification" EXACT [] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0042545 ! cell wall modification [Term] id: GO:0009828 name: plant-type cell wall loosening namespace: biological_process def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] is_a: GO:0009827 ! plant-type cell wall modification [Term] id: GO:0009829 name: cell wall modification involved in fruit ripening namespace: biological_process def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to fruit ripening." [GOC:lr] synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0009835 ! fruit ripening [Term] id: GO:0009830 name: cell wall modification involved in abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb] synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0044277 ! cell wall disassembly relationship: part_of GO:0009838 ! abscission [Term] id: GO:0009831 name: plant-type cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cell wall modification during cell expansion" BROAD [] synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED [] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth [Term] id: GO:0009832 name: plant-type cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009833 name: plant-type primary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] synonym: "primary cell wall anabolism" BROAD [] synonym: "primary cell wall biogenesis" EXACT [] synonym: "primary cell wall biosynthetic process" BROAD [] synonym: "primary cell wall formation" BROAD [] synonym: "primary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis [Term] id: GO:0009834 name: plant-type secondary cell wall biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall anabolism" BROAD [] synonym: "secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall biosynthetic process" BROAD [] synonym: "secondary cell wall formation" BROAD [] synonym: "secondary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009835 name: fruit ripening namespace: biological_process def: "An aging process that has as participant a fruit. Ripening causes changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) and may make it more attractive to animals and aid in seed dispersal." [GOC:lr] subset: goslim_plant synonym: "fruit maturation" RELATED [GOC:PO_curators] synonym: "fruit senescence" RELATED [GOC:PO_curators] xref: Wikipedia:Ripening is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0007568 ! aging is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0010154 ! fruit development [Term] id: GO:0009836 name: fruit ripening, climacteric namespace: biological_process def: "A fruit ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! fruit ripening [Term] id: GO:0009837 name: fruit ripening, non-climacteric namespace: biological_process def: "A fruit ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! fruit ripening [Term] id: GO:0009838 name: abscission namespace: biological_process def: "The controlled shedding of a body part." [ISBN:0140514031] subset: goslim_plant xref: Wikipedia:Abscission is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0009839 name: obsolete SCF complex substrate recognition subunit namespace: cellular_component def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "SCF complex substrate recognition subunit" EXACT [] is_obsolete: true replaced_by: GO:0019005 [Term] id: GO:0009840 name: chloroplastic endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009841 name: mitochondrial endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009842 name: cyanelle namespace: cellular_component def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a double membrane with a peptidoglycan layer in the intermembrane space between the two envelope membranes. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:052131687, ISBN:1402001894] synonym: "cyanoplast" EXACT [ISBN:1402001894] synonym: "muroplast" EXACT [ISBN:1402001894] is_a: GO:0009536 ! plastid [Term] id: GO:0009843 name: cyanelle thylakoid namespace: cellular_component def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] is_a: GO:0031976 ! plastid thylakoid relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0009844 name: obsolete germination namespace: biological_process alt_id: GO:0009565 def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] comment: This term was made obsolete because it is a grouping term without biological significance. synonym: "germination" EXACT [] is_obsolete: true [Term] id: GO:0009845 name: seed germination namespace: biological_process def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] xref: Wikipedia:Germination#Seed_germination is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0090351 ! seedling development [Term] id: GO:0009846 name: pollen germination namespace: biological_process def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] is_a: GO:0022414 ! reproductive process is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009847 name: spore germination namespace: biological_process def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] is_a: GO:0032502 ! developmental process [Term] id: GO:0009848 name: indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] synonym: "IAA biosynthetic process via tryptophan" EXACT [] synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] synonym: "indoleacetic acid formation via tryptophan" EXACT [] synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009849 name: tryptophan-independent indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009850 name: auxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] synonym: "auxin metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009851 name: auxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] synonym: "auxin anabolism" EXACT [] synonym: "auxin biosynthesis" EXACT [] synonym: "auxin formation" EXACT [] synonym: "auxin synthesis" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009852 name: auxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] synonym: "auxin breakdown" EXACT [] synonym: "auxin catabolism" EXACT [] synonym: "auxin degradation" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009853 name: photorespiration namespace: biological_process def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732] xref: MetaCyc:PWY-181 xref: Wikipedia:Photorespiration is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009854 name: oxidative photosynthetic carbon pathway namespace: biological_process def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399] is_a: GO:0043094 ! cellular metabolic compound salvage relationship: part_of GO:0009853 ! photorespiration [Term] id: GO:0009855 name: determination of bilateral symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] synonym: "determination of bilateral asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry [Term] id: GO:0009856 name: pollination namespace: biological_process def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the female reproductive organs of a plant and continuing up to, but not including, fertilization, as defined by sperm-egg cell fusion." [GOC:tb, PMID:10973091] subset: goslim_plant xref: Wikipedia:Pollination is_a: GO:0022414 ! reproductive process relationship: part_of GO:0044706 ! multi-multicellular organism process [Term] id: GO:0009858 name: obsolete compatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "compatible pollen-pistil interaction" EXACT [] is_obsolete: true [Term] id: GO:0009859 name: pollen hydration namespace: biological_process def: "The process in which water is taken up by pollen." [GOC:lr] is_a: GO:0006833 ! water transport is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009860 name: pollen tube growth namespace: biological_process def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009932 ! cell tip growth is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009861 name: jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] is_a: GO:0009611 ! response to wounding is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009862 name: systemic acquired resistance, salicylic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0009863 ! salicylic acid mediated signaling pathway relationship: part_of GO:0009627 ! systemic acquired resistance [Term] id: GO:0009863 name: salicylic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] synonym: "salicylic acid mediated signal transduction" EXACT [GOC:signaling] synonym: "salicylic acid mediated signalling pathway" EXACT [] synonym: "salicylic acid-mediated signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0071446 ! cellular response to salicylic acid stimulus [Term] id: GO:0009864 name: induced systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009867 ! jasmonic acid mediated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009865 name: pollen tube adhesion namespace: biological_process def: "The process in which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0098609 ! cell-cell adhesion is_a: GO:0098740 ! multi organism cell adhesion relationship: part_of GO:0009875 ! pollen-pistil interaction relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009866 name: induced systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002252 ! immune effector process is_a: GO:0009873 ! ethylene-activated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009867 name: jasmonic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy, PMID:16478936, PMID:19522558, PMID:20159850] synonym: "JA signaling" EXACT [PMID:20159850] synonym: "jasmonate signaling" RELATED [PMID:16478936] synonym: "jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071395 ! cellular response to jasmonic acid stimulus [Term] id: GO:0009868 name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009867 ! jasmonic acid mediated signaling pathway relationship: part_of GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009869 name: obsolete incompatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] comment: This term was made obsolete because it represents a phenotype. synonym: "incompatible pollen-pistil interaction" EXACT [] is_obsolete: true [Term] id: GO:0009870 name: defense response signaling pathway, resistance gene-dependent namespace: biological_process def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339] synonym: "defence response signaling pathway, resistance gene-dependent" EXACT [] synonym: "defence response signalling pathway, resistance gene-dependent" EXACT [] synonym: "defense response signalling pathway, resistance gene-dependent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0009871 name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0009873 ! ethylene-activated signaling pathway relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009872 name: obsolete gametophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "gametophytic self-incompatibility" EXACT [] is_obsolete: true [Term] id: GO:0009873 name: ethylene-activated signaling pathway namespace: biological_process def: "A series of molecular signals generated by the reception of ethylene (ethene, C2H4) by a receptor and ending with modulation of a cellular process, e.g. transcription." [GOC:jy, PMID:24012247] synonym: "ethene mediated signaling pathway" RELATED [] synonym: "ethene mediated signalling pathway" EXACT [] synonym: "ethylene mediated signaling pathway" RELATED [] synonym: "ethylene mediated signalling pathway" RELATED [] synonym: "ethylene signal transduction" RELATED [PMID:24012247] synonym: "ethylene signaling pathway" RELATED [PMID:24287137] is_a: GO:0000160 ! phosphorelay signal transduction system is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071369 ! cellular response to ethylene stimulus [Term] id: GO:0009874 name: obsolete sporophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. synonym: "sporophytic self-incompatibility" EXACT [] is_obsolete: true [Term] id: GO:0009875 name: pollen-pistil interaction namespace: biological_process def: "The interaction between a pollen grain and pistil." [PMID:27899537] synonym: "pollen-gynoecium interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009876 name: pollen adhesion namespace: biological_process def: "The process in which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] is_a: GO:0022414 ! reproductive process is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009877 name: nodulation namespace: biological_process def: "The formation of nitrogen-fixing root nodules on plant roots." [UniProtKB-KW:KW-0536] synonym: "nodule development" EXACT [GOC:jl] synonym: "nodule formation" EXACT [GOC:jl] is_a: GO:0044403 ! symbiont process [Term] id: GO:0009878 name: nodule morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the nodule are generated and organized." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0044111 ! development involved in symbiotic interaction relationship: part_of GO:0009877 ! nodulation [Term] id: GO:0009879 name: determination of radial symmetry namespace: biological_process def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] synonym: "determination of radial asymmetry" EXACT [GOC:dph] is_a: GO:0009799 ! specification of symmetry relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0009881 name: photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] xref: reactome:R-HSA-2465917 "Photons induce isomerisation of 11c-retinyl to at-retinyl" xref: reactome:R-HSA-74101 "Photons induce isomerization of 11c-retinyl to at-retinyl" is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0009882 name: blue light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0009883 name: red or far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] synonym: "red/far-red light photoreceptor activity" EXACT [] is_a: GO:0009881 ! photoreceptor activity [Term] id: GO:0009884 name: cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:lr, GOC:signaling] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0009885 name: transmembrane histidine kinase cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate." [GOC:lr, GOC:mah] is_a: GO:0009784 ! transmembrane receptor histidine kinase activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0009886 name: post-embryonic animal morphogenesis namespace: biological_process def: "The process, occurring after animal embryonic development, by which anatomical structures are generated and organized." [GOC:go_curators] synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0009887 name: animal organ morphogenesis namespace: biological_process def: "Morphogenesis of an animal organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process alt_id: GO:0044252 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "inhibition of organismal metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] synonym: "negative regulation of multicellular organismal metabolic process" NARROW [] synonym: "negative regulation of organismal metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process alt_id: GO:0044253 def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "positive regulation of multicellular organismal metabolic process" NARROW [] synonym: "positive regulation of organismal metabolism" NARROW [] synonym: "stimulation of metabolic process" NARROW [] synonym: "stimulation of organismal metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "up-regulation of organismal metabolic process" NARROW [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009897 name: external side of plasma membrane namespace: cellular_component def: "The leaflet of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] synonym: "external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "juxtamembrane" BROAD [] synonym: "outer surface of cytoplasmic membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009898 name: cytoplasmic side of plasma membrane namespace: cellular_component def: "The leaflet the plasma membrane that faces the cytoplasm and any proteins embedded or anchored in it or attached to its surface." [GOC:dos, GOC:tb] synonym: "internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "internal side of plasma membrane" EXACT [] synonym: "juxtamembrane" BROAD [] is_a: GO:0044459 ! plasma membrane part is_a: GO:0098562 ! cytoplasmic side of membrane [Term] id: GO:0009899 name: ent-kaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaur-16-ene + diphosphate." [EC:4.2.3.19, RHEA:22220] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] xref: EC:4.2.3.19 xref: KEGG:R05092 xref: MetaCyc:4.2.3.19-RXN xref: RHEA:22220 is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0009900 name: dehiscence namespace: biological_process def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] xref: Wikipedia:Dehiscence_(botany) is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0009901 name: anther dehiscence namespace: biological_process def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] is_a: GO:0009900 ! dehiscence relationship: part_of GO:0048653 ! anther development [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process in which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0019750 ! chloroplast localization is_a: GO:0051667 ! establishment of plastid localization [Term] id: GO:0009903 name: chloroplast avoidance movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] synonym: "high-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009904 name: chloroplast accumulation movement namespace: biological_process def: "The relocation process in which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] synonym: "low-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009905 name: ent-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, RHEA:14841] synonym: "diterpene cyclase activity" BROAD [] synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] xref: EC:5.5.1.13 xref: KEGG:R02068 xref: MetaCyc:5.5.1.13-RXN xref: RHEA:14841 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0009906 name: response to photoperiod, blue light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009637 ! response to blue light is_a: GO:0009648 ! photoperiodism [Term] id: GO:0009907 name: response to photoperiod, red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009648 ! photoperiodism is_a: GO:0010114 ! response to red light [Term] id: GO:0009908 name: flower development namespace: biological_process alt_id: GO:0048409 def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] subset: goslim_plant is_a: GO:0090567 ! reproductive shoot system development [Term] id: GO:0009909 name: regulation of flower development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048831 ! regulation of shoot system development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0009908 ! flower development [Term] id: GO:0009910 name: negative regulation of flower development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "down regulation of flower development" EXACT [] synonym: "down-regulation of flower development" EXACT [] synonym: "downregulation of flower development" EXACT [] synonym: "inhibition of flower development" NARROW [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0009908 ! flower development [Term] id: GO:0009911 name: positive regulation of flower development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "activation of flower development" NARROW [] synonym: "stimulation of flower development" NARROW [] synonym: "up regulation of flower development" EXACT [] synonym: "up-regulation of flower development" EXACT [] synonym: "upregulation of flower development" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0009908 ! flower development [Term] id: GO:0009912 name: auditory receptor cell fate commitment namespace: biological_process def: "The process in which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] synonym: "auditory hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment is_a: GO:0072148 ! epithelial cell fate commitment relationship: part_of GO:0042491 ! inner ear auditory receptor cell differentiation [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process alt_id: GO:0043355 def: "The process in which a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0008544 ! epidermis development [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009915 name: phloem sucrose loading namespace: biological_process def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] is_a: GO:0015770 ! sucrose transport is_a: GO:0110126 ! phloem loading [Term] id: GO:0009916 name: alternative oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0009917 name: sterol 5-alpha reductase activity namespace: molecular_function def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009918 name: sterol delta7 reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] synonym: "sterol delta-7 reductase activity" EXACT [] xref: MetaCyc:RXN-707 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009919 name: obsolete cytokinesis (sensu Viridiplantae) namespace: biological_process def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] comment: This term was made obsolete because its meaning was changed significantly. synonym: "cytokinesis (sensu Viridiplantae)" EXACT [] is_obsolete: true consider: GO:0000911 [Term] id: GO:0009920 name: cell plate formation involved in plant-type cell wall biogenesis namespace: biological_process def: "The cell cycle process in which the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0000919 ! cell plate assembly is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0009832 ! plant-type cell wall biogenesis relationship: part_of GO:0061640 ! cytoskeleton-dependent cytokinesis relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0009921 name: auxin efflux carrier complex namespace: cellular_component def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0009922 name: fatty acid elongase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN xref: reactome:R-HSA-2046083 "Elongation of arachidonyl-CoA to docosatetraenoyl-CoA" xref: reactome:R-HSA-2046088 "Elongation of stearidonoyl-CoA to eicosatetraenoyl-CoA" xref: reactome:R-HSA-2046090 "Elongation of docosapentaenoyl-CoA to tetracosapentaenoyl-CoA" xref: reactome:R-HSA-2046094 "Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA" xref: reactome:R-HSA-2046095 "Elongation of docosatetraenoyl-CoA to tetracosatetraenoyl-CoA" xref: reactome:R-HSA-2046100 "Elongation of eicosapentaenoyl-CoA to docosapentaenoyl-CoA" xref: reactome:R-HSA-548800 "ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA" xref: reactome:R-HSA-548814 "ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA" xref: reactome:R-HSA-548815 "ELOVL7 elongates ICS-CoA and Mal-CoA to 3ODC-CoA" xref: reactome:R-HSA-548830 "ELOVL1,4 elongate TCS-CoA and Mal-CoA to 3OHC-CoA" is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0009923 name: fatty acid elongase complex namespace: cellular_component def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex is_a: GO:1990234 ! transferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0009924 name: octadecanal decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] synonym: "octadecanal alkane-lyase activity" EXACT [] xref: EC:4.1.99.5 xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN xref: RHEA:30415 is_a: GO:0071771 ! aldehyde decarbonylase activity [Term] id: GO:0009925 name: basal plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0016323 ! basolateral plasma membrane relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0009926 name: auxin polar transport namespace: biological_process def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] is_a: GO:0060918 ! auxin transport [Term] id: GO:0009927 name: histidine phosphotransfer kinase activity namespace: molecular_function def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] comment: Added is_a molecular transducer activity see https://github.com/geneontology/go-ontology/issues/15611 is_a: GO:0004672 ! protein kinase activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0009930 name: longitudinal side of cell surface namespace: cellular_component def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] is_a: GO:0044464 ! cell part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009931 name: calcium-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reactions: ATP + a protein serine = ADP + protein serine phosphate; and ATP + a protein threonine = ADP + protein threonine phosphate. These reactions are dependent on the presence of calcium ions." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0010857 ! calcium-dependent protein kinase activity [Term] id: GO:0009932 name: cell tip growth namespace: biological_process def: "Growth that occurs specifically at the tip of a cell." [GOC:jid] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0009933 name: meristem structural organization namespace: biological_process def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] synonym: "meristem organisation" BROAD [] synonym: "meristem organization" BROAD [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0009934 name: regulation of meristem structural organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid] synonym: "regulation of meristem organisation" EXACT [] synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048509 ! regulation of meristem development relationship: regulates GO:0009933 ! meristem structural organization [Term] id: GO:0009935 name: obsolete nutrient import namespace: biological_process def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. synonym: "nutrient import" EXACT [] synonym: "nutrient uptake" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0009936 name: obsolete expansin namespace: molecular_function def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "expansin" EXACT [] is_obsolete: true consider: GO:0009505 consider: GO:0016049 [Term] id: GO:0009937 name: regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] synonym: "regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009938 name: negative regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009968 ! negative regulation of signal transduction relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009939 name: positive regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "activation of gibberellic acid mediated signaling" NARROW [] synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0009967 ! positive regulation of signal transduction relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009940 name: amino-terminal vacuolar sorting propeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin-coated vesicles." [GOC:sm, PMID:10871276] is_a: GO:0010209 ! vacuolar sorting signal binding [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009942 name: longitudinal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] synonym: "apical-basal pattern specification" EXACT [] synonym: "longitudinal axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0009943 name: adaxial/abaxial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] synonym: "adaxial/abaxial determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009955 ! adaxial/abaxial pattern specification [Term] id: GO:0009944 name: polarity specification of adaxial/abaxial axis namespace: biological_process def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009943 ! adaxial/abaxial axis specification [Term] id: GO:0009945 name: radial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009946 name: proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "proximal/distal axis determination" RELATED [GOC:dph] synonym: "proximodistal axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0009947 name: centrolateral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:dsz, GOC:tb, ISBN:0865427429] synonym: "centrolateral axis determination" RELATED [GOC:dph] synonym: "mediolateral axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0097353 ! centrolateral pattern formation [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009952 ! anterior/posterior pattern specification [Term] id: GO:0009949 name: polarity specification of anterior/posterior axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0009950 name: dorsal/ventral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] synonym: "dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0009951 name: polarity specification of dorsal/ventral axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah] synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0009952 name: anterior/posterior pattern specification namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009953 name: dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "dorsal/ventral pattern specification" NARROW [] synonym: "dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0003002 ! regionalization [Term] id: GO:0009954 name: proximal/distal pattern formation namespace: biological_process def: "The regionalization process in which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "proximal/distal pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009955 name: adaxial/abaxial pattern specification namespace: biological_process def: "The regionalization process in which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "adaxial/abaxial pattern formation" RELATED [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009956 name: radial pattern formation namespace: biological_process def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "radial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009957 name: epidermal cell fate specification namespace: biological_process alt_id: GO:0043356 def: "The process in which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0009913 ! epidermal cell differentiation [Term] id: GO:0009958 name: positive gravitropism namespace: biological_process def: "The orientation of plant parts towards gravity." [GOC:sm] synonym: "root gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009959 name: negative gravitropism namespace: biological_process def: "The orientation of plant parts away from gravity." [GOC:sm] synonym: "shoot gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009960 name: endosperm development namespace: biological_process def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009888 ! tissue development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009961 name: response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] is_a: GO:0043200 ! response to amino acid [Term] id: GO:0009962 name: regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "regulation of flavonoid anabolism" EXACT [] synonym: "regulation of flavonoid biosynthesis" EXACT [] synonym: "regulation of flavonoid formation" EXACT [] synonym: "regulation of flavonoid synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009963 name: positive regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "activation of flavonoid biosynthetic process" NARROW [] synonym: "positive regulation of flavonoid anabolism" EXACT [] synonym: "positive regulation of flavonoid biosynthesis" EXACT [] synonym: "positive regulation of flavonoid formation" EXACT [] synonym: "positive regulation of flavonoid synthesis" EXACT [] synonym: "stimulation of flavonoid biosynthetic process" NARROW [] synonym: "up regulation of flavonoid biosynthetic process" EXACT [] synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] synonym: "upregulation of flavonoid biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0009962 ! regulation of flavonoid biosynthetic process relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009964 name: negative regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] synonym: "down regulation of flavonoid biosynthetic process" EXACT [] synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] synonym: "downregulation of flavonoid biosynthetic process" EXACT [] synonym: "inhibition of flavonoid biosynthetic process" NARROW [] synonym: "negative regulation of flavonoid anabolism" EXACT [] synonym: "negative regulation of flavonoid biosynthesis" EXACT [] synonym: "negative regulation of flavonoid formation" EXACT [] synonym: "negative regulation of flavonoid synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0009962 ! regulation of flavonoid biosynthetic process relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009965 name: leaf morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the leaf are generated and organized." [GOC:go_curators] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process alt_id: GO:0035466 def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "regulation of signaling pathway" RELATED [] synonym: "regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process alt_id: GO:0035468 def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "activation of signal transduction" NARROW [] synonym: "positive regulation of signaling pathway" RELATED [] synonym: "positive regulation of signalling pathway" RELATED [GOC:mah] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process alt_id: GO:0035467 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction." [GOC:sm] synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] synonym: "negative regulation of signaling pathway" RELATED [] synonym: "negative regulation of signalling pathway" RELATED [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009969 name: xyloglucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of (1->4)-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:sm] synonym: "xyloglucan anabolism" EXACT [] synonym: "xyloglucan biosynthesis" EXACT [] synonym: "xyloglucan formation" EXACT [] synonym: "xyloglucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0010411 ! xyloglucan metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0009970 name: cellular response to sulfate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] synonym: "cellular response to sulphate starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0009971 name: anastral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055048 ! anastral spindle assembly [Term] id: GO:0009972 name: cytidine deamination namespace: biological_process def: "The removal of amino group in the presence of water." [GOC:sm] is_a: GO:0006216 ! cytidine catabolic process [Term] id: GO:0009973 name: adenylyl-sulfate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + sulfite + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "APS reductase activity" EXACT [EC:1.8.99.2] synonym: "APS-reductase" EXACT [EC:1.8.99.2] xref: EC:1.8.99.2 xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN xref: RHEA:24240 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0009974 name: zeinoxanthin epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: zeinoxanthin + NADPH + O2 + H+ = lutein + NADP+ + H2O. Adds a hydroxyl group to the epsilon ring of the alpha-carotene." [MetaCyc:RXN-5962, PMID:8837513] xref: EC:1.14.99 xref: MetaCyc:RXN-5962 is_a: GO:0072374 ! carotene epsilon hydroxylase activity [Term] id: GO:0009975 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009976 name: tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0009977 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function alt_id: GO:0015557 def: "Catalysis of the transfer of proteins from one side of a membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245, PMID:25494301] synonym: "arginine targeting transmembrane transporter activity" EXACT [] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] synonym: "twin-arginine targeting transmembrane transporter activity" EXACT [] is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0009978 name: allene oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: MetaCyc:RXN1F-19 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0009979 name: 16:0 monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307] is_a: GO:0042389 ! omega-3 fatty acid desaturase activity [Term] id: GO:0009980 name: obsolete glutamate carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating groups, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamate carboxypeptidase activity" EXACT [] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] xref: EC:3.4.17.11 xref: MetaCyc:3.4.17.11-RXN is_obsolete: true replaced_by: GO:0004180 [Term] id: GO:0009982 name: pseudouridine synthase activity namespace: molecular_function alt_id: GO:0016439 def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [GOC:mah] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. xref: reactome:R-HSA-6782381 "PUS1 isoform 2 transforms uridine residues to pseudouridine in the anticodon stems of tRNAs" xref: reactome:R-HSA-6786583 "PUS7 transforms uridine to pseudouridine in tRNAs" xref: reactome:R-HSA-6787566 "PUS1 isoform 1 transforms uridine-27, uridine-28 yielding pseudouridine in tRNA(Lys,Ser)" xref: reactome:R-HSA-6790905 "Box H/ACA snoRNP transforms uridine to pseudouridine in pre-rRNA" xref: reactome:R-HSA-8870289 "PUS3 transforms uridine-39 to pseudouridine-39 in tRNA" is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0009983 name: obsolete tyrosine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "tyrosine aminopeptidase activity" EXACT [] is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0009984 name: obsolete adenylate forming enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. synonym: "adenylate forming enzyme activity" EXACT [] is_obsolete: true consider: GO:0046033 [Term] id: GO:0009985 name: obsolete dihydroflavonol(thiole) lyase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:tb] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "dihydroflavonol(thiole) lyase activity" EXACT [] is_obsolete: true [Term] id: GO:0009986 name: cell surface namespace: cellular_component alt_id: GO:0009928 alt_id: GO:0009929 def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. subset: goslim_pir synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0044763 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_plant synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] synonym: "single-organism cellular process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009988 name: cell-cell recognition namespace: biological_process def: "Cell recognition between cells. May involve the formation of specialized cell junctions." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009989 name: cell-matrix recognition namespace: biological_process def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009990 name: contact guidance namespace: biological_process def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] is_a: GO:0009989 ! cell-matrix recognition [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] subset: goslim_plant is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009992 name: cellular water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of water within a cell." [GOC:dph, GOC:tb] synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0006884 ! cell volume homeostasis is_a: GO:0030104 ! water homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0009995 name: soluble molecule recognition namespace: biological_process def: "The recognition of soluble molecules in the environment." [GOC:go_curators] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009996 name: negative regulation of cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] synonym: "down regulation of cell fate specification" EXACT [] synonym: "down-regulation of cell fate specification" EXACT [] synonym: "downregulation of cell fate specification" EXACT [] synonym: "inhibition of cell fate specification" NARROW [] synonym: "suppression of cell fate" EXACT [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0042659 ! regulation of cell fate specification relationship: negatively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0009997 name: negative regulation of cardioblast cell fate specification namespace: biological_process alt_id: GO:0042687 def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "down regulation of cardioblast cell fate specification" EXACT [] synonym: "down-regulation of cardioblast cell fate specification" EXACT [] synonym: "downregulation of cardioblast cell fate specification" EXACT [] synonym: "inhibition of cardioblast cell fate specification" NARROW [] synonym: "suppression of cardioblast cell fate" EXACT [] is_a: GO:0042686 ! regulation of cardioblast cell fate specification is_a: GO:0051892 ! negative regulation of cardioblast differentiation is_a: GO:2000044 ! negative regulation of cardiac cell fate specification relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0009998 name: negative regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] synonym: "down regulation of retinal cone cell fate specification" EXACT [] synonym: "down-regulation of retinal cone cell fate specification" EXACT [] synonym: "downregulation of retinal cone cell fate specification" EXACT [] synonym: "inhibition of retinal cone cell fate specification" NARROW [] synonym: "negative regulation of retina cone cell fate specification" EXACT [] synonym: "suppression of retina cone cell fate" EXACT [] synonym: "suppression of retinal cone cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042673 ! regulation of retinal cone cell fate specification is_a: GO:0060226 ! negative regulation of retinal cone cell fate commitment relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0009999 name: negative regulation of auditory receptor cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] synonym: "down regulation of auditory receptor cell fate specification" EXACT [] synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] synonym: "downregulation of auditory receptor cell fate specification" EXACT [] synonym: "inhibition of auditory receptor cell fate specification" NARROW [] synonym: "negative regulation of auditory hair cell fate specification" EXACT [] synonym: "suppression of auditory receptor cell fate" EXACT [] synonym: "suppression of hair cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042669 ! regulation of inner ear auditory receptor cell fate specification is_a: GO:0045608 ! negative regulation of inner ear auditory receptor cell differentiation relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process alt_id: GO:0007404 alt_id: GO:0043360 def: "The process in which a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiocyte differentiation is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0010004 name: gastrulation involving germ band extension namespace: biological_process def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001703 ! gastrulation with mouth forming first [Term] id: GO:0010005 name: cortical microtubule, transverse to long axis namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] is_a: GO:0055028 ! cortical microtubule [Term] id: GO:0010006 name: Toc complex namespace: cellular_component def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] is_a: GO:0044434 ! chloroplast part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010007 name: magnesium chelatase complex namespace: cellular_component def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] is_a: GO:0044434 ! chloroplast part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0010008 name: endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endosome." [GOC:mah] synonym: "endosomal membrane" EXACT [NIF_Subcellular:sao978443756] xref: NIF_Subcellular:sao978443756 is_a: GO:0044440 ! endosomal part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane [Term] id: GO:0010009 name: cytoplasmic side of endosome membrane namespace: cellular_component def: "The side (leaflet) of the endosome membrane that faces the cytoplasm." [GOC:lr] synonym: "external leaflet of endosome membrane" EXACT [GOC:ab] synonym: "external side of endosome membrane" EXACT [] is_a: GO:0044440 ! endosomal part is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0010011 name: auxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] synonym: "auxin receptor" NARROW [] is_a: GO:0042562 ! hormone binding [Term] id: GO:0010012 name: steroid 22-alpha hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0010013 name: N-1-naphthylphthalamic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] is_a: GO:0008144 ! drug binding is_a: GO:0033218 ! amide binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0097159 ! organic cyclic compound binding [Term] id: GO:0010014 name: meristem initiation namespace: biological_process def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009933 ! meristem structural organization [Term] id: GO:0010015 name: root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of roots are generated and organized. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0048364 ! root development [Term] id: GO:0010016 name: shoot system morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the shoot are generated and organized. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] synonym: "shoot morphogenesis" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0010017 name: red or far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red or far red light signaling pathway" EXACT [GOC:bf, GOC:tb] synonym: "red or far-red light signal transduction" EXACT [GOC:signaling] synonym: "red or far-red light signalling pathway" EXACT [] synonym: "red/far red light signaling pathway" EXACT [] is_a: GO:0007165 ! signal transduction is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0010018 name: far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "far red light signalling pathway" EXACT [] synonym: "far red signaling pathway" EXACT [GOC:tb] synonym: "far-red light signal transduction" EXACT [GOC:signaling] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071490 ! cellular response to far red light [Term] id: GO:0010019 name: chloroplast-nucleus signaling pathway namespace: biological_process def: "The process in which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] synonym: "chloroplast-nucleus signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission [Term] id: GO:0010021 name: amylopectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1->4) linked alpha glucose units with alpha-(1->6) linkages." [ISBN:0943088399] synonym: "amylopectin anabolism" EXACT [] synonym: "amylopectin biosynthesis" EXACT [] synonym: "amylopectin formation" EXACT [] synonym: "amylopectin synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process is_a: GO:2000896 ! amylopectin metabolic process [Term] id: GO:0010022 name: meristem determinacy namespace: biological_process def: "The process in which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010023 name: proanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] synonym: "proanthocyanidin anabolism" EXACT [] synonym: "proanthocyanidin biosynthesis" EXACT [] synonym: "proanthocyanidin formation" EXACT [] synonym: "proanthocyanidin synthesis" EXACT [] xref: MetaCyc:PWY-641 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process [Term] id: GO:0010024 name: phytochromobilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] synonym: "phytochromobilin anabolism" EXACT [] synonym: "phytochromobilin biosynthesis" EXACT [] synonym: "phytochromobilin formation" EXACT [] synonym: "phytochromobilin synthesis" EXACT [] is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051202 ! phytochromobilin metabolic process [Term] id: GO:0010025 name: wax biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] synonym: "wax anabolism" EXACT [] synonym: "wax biosynthesis" EXACT [] synonym: "wax formation" EXACT [] synonym: "wax synthesis" EXACT [] xref: MetaCyc:PWY-282 is_a: GO:0010166 ! wax metabolic process is_a: GO:1901570 ! fatty acid derivative biosynthetic process [Term] id: GO:0010026 name: trichome differentiation namespace: biological_process alt_id: GO:0048271 def: "The process in which a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433] synonym: "trichome cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0090558 ! plant epidermis development [Term] id: GO:0010027 name: thylakoid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. synonym: "thylakoid membrane organisation" EXACT [GOC:curators] synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0010028 name: xanthophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] xref: MetaCyc:PWY-1141 xref: Wikipedia:Xanthophyll#Xanthophyll_cycle is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0010029 name: regulation of seed germination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] is_a: GO:1900140 ! regulation of seedling development relationship: regulates GO:0009845 ! seed germination [Term] id: GO:0010030 name: positive regulation of seed germination namespace: biological_process def: "Any process that activates or increase the rate of seed germination." [GOC:sm] synonym: "activation of seed germination" NARROW [] synonym: "stimulation of seed germination" NARROW [] synonym: "up regulation of seed germination" EXACT [] synonym: "up-regulation of seed germination" EXACT [] synonym: "upregulation of seed germination" EXACT [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048582 ! positive regulation of post-embryonic development relationship: positively_regulates GO:0009845 ! seed germination [Term] id: GO:0010031 name: circumnutation namespace: biological_process def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation is_a: GO:0070192 ! chromosome organization involved in meiotic cell cycle [Term] id: GO:0010033 name: response to organic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010034 name: response to acetate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010033 ! response to organic substance is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010036 name: response to boron-containing substance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron-containing substance stimulus." [GOC:sm] synonym: "response to boron" EXACT [GOC:curators] is_a: GO:0042221 ! response to chemical [Term] id: GO:0010037 name: response to carbon dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] is_a: GO:0010033 ! response to organic substance is_a: GO:0072347 ! response to anesthetic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010040 name: response to iron(II) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] synonym: "response to iron(II)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010041 name: response to iron(III) ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] synonym: "response to iron(III)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010042 name: response to manganese ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] synonym: "response to manganese" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010043 name: response to zinc ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] synonym: "response to zinc" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010044 name: response to aluminum ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] synonym: "response to aluminium ion" EXACT [] synonym: "response to aluminum" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010045 name: response to nickel cation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus." [GOC:sm] synonym: "response to nickel" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010046 name: response to mycotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi." [GOC:sm] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0010047 name: fruit dehiscence namespace: biological_process def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] is_a: GO:0009900 ! dehiscence [Term] id: GO:0010048 name: vernalization response namespace: biological_process def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] is_a: GO:0009409 ! response to cold [Term] id: GO:0010049 name: acquisition of plant reproductive competence namespace: biological_process def: "The process in which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] synonym: "acquisition of reproductive competence" BROAD [] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010050 name: vegetative phase change namespace: biological_process def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010051 name: xylem and phloem pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue pattern formation" EXACT [] is_a: GO:0003002 ! regionalization [Term] id: GO:0010052 name: guard cell differentiation namespace: biological_process def: "The process in which a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] synonym: "stomatal cell differentiation" RELATED [] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010053 name: root epidermal cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0090558 ! plant epidermis development [Term] id: GO:0010054 name: trichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] synonym: "trichoblast cell differentiation" EXACT [] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010055 name: atrichoblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010056 name: atrichoblast fate specification namespace: biological_process def: "The process involved in the specification of an atrichoblast." [GOC:tb] is_a: GO:0090628 ! plant epidermal cell fate specification relationship: part_of GO:0010055 ! atrichoblast differentiation [Term] id: GO:0010057 name: trichoblast fate specification namespace: biological_process def: "The process involved in the specification of a trichoblast." [GOC:tb] is_a: GO:0090628 ! plant epidermal cell fate specification relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0010058 name: regulation of atrichoblast fate specification namespace: biological_process def: "Any process that modulates atrichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1903888 ! regulation of plant epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis relationship: regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010059 name: positive regulation of atrichoblast fate specification namespace: biological_process def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] synonym: "activation of atrichoblast fate" NARROW [] synonym: "stimulation of atrichoblast fate" NARROW [] synonym: "up regulation of atrichoblast fate" EXACT [] synonym: "up-regulation of atrichoblast fate" EXACT [] synonym: "upregulation of atrichoblast fate" EXACT [] is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis relationship: positively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010060 name: negative regulation of atrichoblast fate specification namespace: biological_process def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] synonym: "down regulation of atrichoblast fate" EXACT [] synonym: "down-regulation of atrichoblast fate" EXACT [] synonym: "downregulation of atrichoblast fate" EXACT [] synonym: "inhibition of atrichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation is_a: GO:1905422 ! negative regulation of plant organ morphogenesis relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010061 name: regulation of trichoblast fate specification namespace: biological_process def: "Any process that modulates trichoblast fate specification." [GOC:tb] is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:1903888 ! regulation of plant epidermal cell differentiation is_a: GO:2000067 ! regulation of root morphogenesis relationship: regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010062 name: negative regulation of trichoblast fate specification namespace: biological_process def: "Any process that suppresses trichoblast fate specification." [GOC:tb] synonym: "down regulation of trichoblast fate" EXACT [] synonym: "down-regulation of trichoblast fate" EXACT [] synonym: "downregulation of trichoblast fate" EXACT [] synonym: "inhibition of trichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:1903889 ! negative regulation of plant epidermal cell differentiation is_a: GO:1905422 ! negative regulation of plant organ morphogenesis relationship: negatively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010063 name: positive regulation of trichoblast fate specification namespace: biological_process def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] synonym: "activation of trichoblast fate" NARROW [] synonym: "stimulation of trichoblast fate" NARROW [] synonym: "up regulation of trichoblast fate" EXACT [] synonym: "up-regulation of trichoblast fate" EXACT [] synonym: "upregulation of trichoblast fate" EXACT [] is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification is_a: GO:1903890 ! positive regulation of plant epidermal cell differentiation is_a: GO:1905423 ! positive regulation of plant organ morphogenesis relationship: positively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010064 name: embryonic shoot morphogenesis namespace: biological_process def: "The process in which the anatomical structures of embryonic shoot are generated and organized." [GOC:tb] synonym: "primary shoot system morphogenesis" EXACT [] is_a: GO:0010016 ! shoot system morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010065 name: primary meristem tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] synonym: "primary meristem histogenesis" EXACT [] is_a: GO:0048508 ! embryonic meristem development [Term] id: GO:0010066 name: ground meristem histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010067 name: procambium histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010068 name: protoderm histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010069 name: zygote asymmetric cytokinesis in embryo sac namespace: biological_process def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] is_a: GO:0000281 ! mitotic cytokinesis is_a: GO:0010070 ! zygote asymmetric cell division is_a: GO:0022414 ! reproductive process relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division [Term] id: GO:0010071 name: root meristem specification namespace: biological_process def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090421 ! embryonic meristem initiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010072 name: primary shoot apical meristem specification namespace: biological_process def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb] synonym: "embryo shoot apical meristem specification" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090421 ! embryonic meristem initiation relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010073 name: meristem maintenance namespace: biological_process def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0010074 name: maintenance of meristem identity namespace: biological_process alt_id: GO:0032503 def: "The process in which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] synonym: "maintenance of meristem cell identity" EXACT [] synonym: "meristem cell maintenance" EXACT [] is_a: GO:0019827 ! stem cell population maintenance relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010075 name: regulation of meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] synonym: "regulation of meristem size" EXACT [GOC:tb] is_a: GO:0048509 ! regulation of meristem development is_a: GO:0048638 ! regulation of developmental growth relationship: part_of GO:0010073 ! meristem maintenance relationship: regulates GO:0035266 ! meristem growth [Term] id: GO:0010076 name: maintenance of floral meristem identity namespace: biological_process def: "The process in which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010077 name: maintenance of inflorescence meristem identity namespace: biological_process def: "The process in which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010078 name: maintenance of root meristem identity namespace: biological_process def: "The process in which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010079 name: maintenance of vegetative meristem identity namespace: biological_process def: "The process in which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010080 name: regulation of floral meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] synonym: "regulation of floral meristem size" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0010075 ! regulation of meristem growth relationship: regulates GO:0010451 ! floral meristem growth [Term] id: GO:0010081 name: regulation of inflorescence meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048831 ! regulation of shoot system development is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0010450 ! inflorescence meristem growth [Term] id: GO:0010082 name: regulation of root meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] synonym: "regulation of root meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:2000280 ! regulation of root development relationship: part_of GO:0010015 ! root morphogenesis relationship: regulates GO:0010449 ! root meristem growth [Term] id: GO:0010083 name: regulation of vegetative meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048831 ! regulation of shoot system development is_a: GO:1905613 ! regulation of developmental vegetative growth relationship: regulates GO:0010448 ! vegetative meristem growth [Term] id: GO:0010084 name: specification of animal organ axis polarity namespace: biological_process def: "The process in which the polarity of an animal organ axis is specified." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0010085 name: polarity specification of proximal/distal axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009946 ! proximal/distal axis specification [Term] id: GO:0010086 name: embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic root are generated and organized." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010087 name: phloem or xylem histogenesis namespace: biological_process def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue development" BROAD [] synonym: "vascular tissue histogenesis" EXACT [] is_a: GO:0009888 ! tissue development [Term] id: GO:0010088 name: phloem development namespace: biological_process def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "phloem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010089 name: xylem development namespace: biological_process def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "xylem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010090 name: trichome morphogenesis namespace: biological_process alt_id: GO:0048272 def: "The process in which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] synonym: "trichome cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010026 ! trichome differentiation relationship: part_of GO:0090626 ! plant epidermis morphogenesis [Term] id: GO:0010091 name: trichome branching namespace: biological_process alt_id: GO:0048274 def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010090 ! trichome morphogenesis [Term] id: GO:0010092 name: specification of animal organ identity namespace: biological_process def: "The regionalization process in which the identity of an animal organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization relationship: part_of GO:0048645 ! animal organ formation [Term] id: GO:0010093 name: specification of floral organ identity namespace: biological_process def: "The process in which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0090701 ! specification of plant organ identity relationship: part_of GO:0048449 ! floral organ formation [Term] id: GO:0010094 name: specification of carpel identity namespace: biological_process def: "The process in which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048462 ! carpel formation [Term] id: GO:0010095 name: specification of petal identity namespace: biological_process def: "The process in which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048451 ! petal formation [Term] id: GO:0010096 name: specification of sepal identity namespace: biological_process def: "The process in which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048453 ! sepal formation [Term] id: GO:0010097 name: specification of stamen identity namespace: biological_process def: "The process in which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048455 ! stamen formation [Term] id: GO:0010098 name: suspensor development namespace: biological_process def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010099 name: regulation of photomorphogenesis namespace: biological_process def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:2000030 ! regulation of response to red or far red light relationship: regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010100 name: negative regulation of photomorphogenesis namespace: biological_process def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] synonym: "down regulation of photomorphogenesis" EXACT [] synonym: "down-regulation of photomorphogenesis" EXACT [] synonym: "downregulation of photomorphogenesis" EXACT [] synonym: "inhibition of photomorphogenesis" NARROW [] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010101 name: post-embryonic root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the post-embryonic root are generated and organized. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0090697 ! post-embryonic plant organ morphogenesis relationship: part_of GO:0048528 ! post-embryonic root development [Term] id: GO:0010102 name: lateral root morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a lateral root are generated and organized. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] is_a: GO:0010101 ! post-embryonic root morphogenesis relationship: part_of GO:0048527 ! lateral root development [Term] id: GO:0010103 name: stomatal complex morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the stomatal complex are generated and organized. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] is_a: GO:0090626 ! plant epidermis morphogenesis is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010016 ! shoot system morphogenesis relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010104 name: regulation of ethylene-activated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) signal transduction." [GOC:tb] synonym: "regulation of ethene mediated signaling pathway" EXACT [] synonym: "regulation of ethene mediated signalling pathway" EXACT [] synonym: "regulation of ethylene mediated signaling pathway" RELATED [] synonym: "regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0070297 ! regulation of phosphorelay signal transduction system relationship: regulates GO:0009873 ! ethylene-activated signaling pathway [Term] id: GO:0010105 name: negative regulation of ethylene-activated signaling pathway namespace: biological_process def: "Any process that stops or prevents ethylene (ethene) signal transduction." [GOC:tb] synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] synonym: "negative regulation of ethylene mediated signaling pathway" RELATED [] synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0010104 ! regulation of ethylene-activated signaling pathway is_a: GO:0070298 ! negative regulation of phosphorelay signal transduction system relationship: negatively_regulates GO:0009873 ! ethylene-activated signaling pathway [Term] id: GO:0010106 name: cellular response to iron ion starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] is_a: GO:0009267 ! cellular response to starvation relationship: part_of GO:0006879 ! cellular iron ion homeostasis [Term] id: GO:0010108 name: detection of glutamine namespace: biological_process def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "glutamine detection" EXACT [] synonym: "glutamine perception" RELATED [] synonym: "glutamine sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010109 name: regulation of photosynthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0015979 ! photosynthesis [Term] id: GO:0010110 name: regulation of photosynthesis, dark reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0010111 name: glyoxysome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] synonym: "glyoxysome organisation" EXACT [GOC:curators] synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007031 ! peroxisome organization is_a: GO:0009657 ! plastid organization [Term] id: GO:0010112 name: regulation of systemic acquired resistance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010113 name: negative regulation of systemic acquired resistance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] synonym: "down regulation of systemic acquired resistance" EXACT [] synonym: "down-regulation of systemic acquired resistance" EXACT [] synonym: "downregulation of systemic acquired resistance" EXACT [] synonym: "inhibition of systemic acquired resistance" NARROW [] is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0045824 ! negative regulation of innate immune response relationship: negatively_regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010114 name: response to red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "response to red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010115 name: regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] synonym: "regulation of abscisic acid anabolism" EXACT [] synonym: "regulation of abscisic acid biosynthesis" EXACT [] synonym: "regulation of abscisic acid formation" EXACT [] synonym: "regulation of abscisic acid synthesis" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process relationship: regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010116 name: positive regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] synonym: "activation of abscisic acid biosynthetic process" NARROW [] synonym: "positive regulation of abscisic acid anabolism" EXACT [] synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] synonym: "positive regulation of abscisic acid formation" EXACT [] synonym: "positive regulation of abscisic acid synthesis" EXACT [] synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010117 name: photoprotection namespace: biological_process def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010118 name: stomatal movement namespace: biological_process def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0010119 name: regulation of stomatal movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0010118 ! stomatal movement [Term] id: GO:0010120 name: camalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] synonym: "camalexin anabolism" EXACT [] synonym: "camalexin biosynthesis" EXACT [] synonym: "camalexin formation" EXACT [] synonym: "camalexin synthesis" EXACT [] xref: MetaCyc:CAMALEXIN-SYN is_a: GO:0009700 ! indole phytoalexin biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052317 ! camalexin metabolic process [Term] id: GO:0010121 name: arginine catabolic process to proline via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] synonym: "arginine breakdown to proline via ornithine" EXACT [] synonym: "arginine degradation to proline via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0019493 ! arginine catabolic process to proline [Term] id: GO:0010122 name: arginine catabolic process to alanine via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] synonym: "arginine breakdown to alanine via ornithine" EXACT [] synonym: "arginine degradation to alanine via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0006522 ! alanine metabolic process is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0010123 name: acetate catabolic process to butyrate, ethanol, acetone and butanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] xref: MetaCyc:CENTFERM-PWY is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0019605 ! butyrate metabolic process is_a: GO:0019654 ! acetate fermentation is_a: GO:0043443 ! acetone metabolic process is_a: GO:0045733 ! acetate catabolic process is_a: GO:0071270 ! 1-butanol metabolic process [Term] id: GO:0010124 name: phenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] synonym: "phenylacetate breakdown" EXACT [] synonym: "phenylacetate catabolism" EXACT [] synonym: "phenylacetate degradation" EXACT [] xref: MetaCyc:PWY0-321 is_a: GO:0009407 ! toxin catabolic process is_a: GO:0009852 ! auxin catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0010125 name: mycothiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] synonym: "mycothiol anabolism" EXACT [] synonym: "mycothiol biosynthesis" EXACT [] synonym: "mycothiol formation" EXACT [] synonym: "mycothiol synthesis" EXACT [] xref: MetaCyc:PWY1G-0 is_a: GO:0010126 ! mycothiol metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0010126 name: mycothiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] synonym: "mycothiol metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0010127 name: mycothiol-dependent detoxification namespace: biological_process def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] xref: MetaCyc:PWY1G-1 xref: MetaCyc:PWY1G-170 is_a: GO:0098754 ! detoxification [Term] id: GO:0010128 name: benzoate catabolic process via CoA ligation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] synonym: "anaerobic benzoate breakdown" EXACT [] synonym: "anaerobic benzoate catabolic process" EXACT [] synonym: "anaerobic benzoate catabolism" EXACT [] synonym: "anaerobic benzoate degradation" EXACT [] xref: MetaCyc:PWY-283 is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0010129 name: anaerobic cyclohexane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] xref: MetaCyc:PWY-301 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010130 name: anaerobic ethylbenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] synonym: "anaerobic ethylbenzene breakdown" EXACT [] synonym: "anaerobic ethylbenzene catabolism" EXACT [] synonym: "anaerobic ethylbenzene degradation" EXACT [] xref: MetaCyc:PWY-481 is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process [Term] id: GO:0010131 name: obsolete sucrose catabolic process, using invertase or sucrose synthase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] comment: This term was made obsolete because it describes two different routes of sucrose catabolism, both of which are represented by molecular functions. synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolic process, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] xref: MetaCyc:PWY-3801 xref: MetaCyc:PWY-621 is_obsolete: true consider: GO:0004564 consider: GO:0005987 consider: GO:0016157 [Term] id: GO:0010132 name: dhurrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] synonym: "dhurrin anabolism" EXACT [] synonym: "dhurrin biosynthesis" EXACT [] synonym: "dhurrin formation" EXACT [] synonym: "dhurrin synthesis" EXACT [] xref: MetaCyc:PWY-861 is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process is_a: GO:1901806 ! beta-glucoside biosynthetic process [Term] id: GO:0010133 name: proline catabolic process to glutamate namespace: biological_process alt_id: GO:0019494 def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] synonym: "proline breakdown to glutamate" EXACT [] synonym: "proline degradation to glutamate" EXACT [] synonym: "proline oxidation" RELATED [] xref: MetaCyc:PROUT-PWY xref: MetaCyc:PWY-4561 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0010134 name: sulfate assimilation via adenylyl sulfate reduction namespace: biological_process def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] xref: MetaCyc:SULFMETII-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0010135 name: ureide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] synonym: "ureide metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0010136 name: ureide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] synonym: "ureide breakdown" EXACT [] synonym: "ureide catabolism" EXACT [] synonym: "ureide degradation" EXACT [] xref: MetaCyc:URDEGR-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0010137 name: ureide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] synonym: "ureide anabolism" EXACT [] synonym: "ureide biosynthesis" EXACT [] synonym: "ureide formation" EXACT [] synonym: "ureide synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0010138 name: pyrimidine ribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] xref: MetaCyc:PWY0-163 is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010139 name: pyrimidine deoxyribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] xref: MetaCyc:PWY0-181 is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010140 name: obsolete adenine, hypoxanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. synonym: "adenine, hypoxanthine and their nucleoside salvage" EXACT [] is_obsolete: true consider: GO:0006168 consider: GO:0006169 consider: GO:0006190 consider: GO:0043103 [Term] id: GO:0010141 name: obsolete guanine, xanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. synonym: "guanine, xanthine and their nucleoside salvage" EXACT [] is_obsolete: true consider: GO:0006178 consider: GO:0006179 consider: GO:0006190 consider: GO:0043103 [Term] id: GO:0010142 name: farnesyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] synonym: "Ac-MVA pathway" NARROW [PMID:14517367] synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] synonym: "isoprenoid pathway" EXACT [] xref: MetaCyc:PWY-922 is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process is_a: GO:1902767 ! isoprenoid biosynthetic process via mevalonate relationship: part_of GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0010143 name: cutin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] synonym: "cutin anabolism" EXACT [] synonym: "cutin biosynthesis" EXACT [] synonym: "cutin formation" EXACT [] synonym: "cutin synthesis" EXACT [] xref: MetaCyc:PWY-321 is_a: GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010144 name: pyridoxal phosphate biosynthetic process from pyridoxamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] synonym: "pyridoxal 5'-phosphate salvage from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] is_a: GO:0009443 ! pyridoxal 5'-phosphate salvage is_a: GO:0042818 ! pyridoxamine metabolic process [Term] id: GO:0010145 name: fructan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] synonym: "fructan metabolism" EXACT [] synonym: "levan metabolic process" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010146 name: fructan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] synonym: "fructan anabolism" EXACT [] synonym: "fructan biosynthesis" EXACT [] synonym: "fructan formation" EXACT [] synonym: "fructan synthesis" EXACT [] synonym: "levan biosynthesis" EXACT [] synonym: "levan biosynthetic process" EXACT [] xref: MetaCyc:PWY-822 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010147 name: fructan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] synonym: "fructan breakdown" EXACT [] synonym: "fructan catabolism" EXACT [] synonym: "fructan degradation" EXACT [] synonym: "levan catabolic process" EXACT [] synonym: "levan catabolism" EXACT [] xref: MetaCyc:PWY-862 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0010148 name: transpiration namespace: biological_process def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] xref: Wikipedia:Transpiration is_a: GO:0006833 ! water transport [Term] id: GO:0010149 name: obsolete senescence namespace: biological_process def: "OBSOLETE. A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819] comment: This term was made obsolete because its name is ambiguous and it is covered by the two more specific terms: 'organ senescence ; GO:0010260' and 'cell aging ; GO:0007569'. synonym: "senescence" EXACT [] xref: Wikipedia:Senescence is_obsolete: true [Term] id: GO:0010150 name: leaf senescence namespace: biological_process def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] is_a: GO:0090693 ! plant organ senescence relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0010151 name: chloroplast elongation namespace: biological_process def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] is_a: GO:0009658 ! chloroplast organization [Term] id: GO:0010152 name: pollen maturation namespace: biological_process def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010153 name: obsolete polar cell elongation namespace: biological_process def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] comment: This term was made obsolete because it did not represent a process discrete from its sibling terms. synonym: "polar cell elongation" EXACT [] synonym: "polarity-dependent cell elongation" NARROW [] is_obsolete: true consider: GO:0042814 consider: GO:0042815 [Term] id: GO:0010154 name: fruit development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010155 name: regulation of proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton transport into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:sm] is_a: GO:1904062 ! regulation of cation transmembrane transport relationship: regulates GO:1902600 ! proton transmembrane transport [Term] id: GO:0010156 name: obsolete sporocyte morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] comment: This term was made obsolete because it was incorrectly defined. synonym: "sporocyte morphogenesis" EXACT [] is_obsolete: true consider: GO:0048533 [Term] id: GO:0010157 name: response to chlorate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010158 name: abaxial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification [Term] id: GO:0010159 name: specification of animal organ position namespace: biological_process def: "The regionalization process in which information that determines the correct position at which animal organ primordia are formed is generated and perceived resulting in correct positioning of the new animal organ." [GOC:curators] is_a: GO:0003002 ! regionalization relationship: part_of GO:0009887 ! animal organ morphogenesis [Term] id: GO:0010160 name: formation of animal organ boundary namespace: biological_process alt_id: GO:0048862 def: "The regionalization process that specifies animal organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0048645 ! animal organ formation [Term] id: GO:0010161 name: red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "red light phototransduction" EXACT [GOC:signaling] synonym: "red light signal transduction" EXACT [GOC:signaling] synonym: "red light signalling pathway" EXACT [] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071491 ! cellular response to red light [Term] id: GO:0010162 name: seed dormancy process namespace: biological_process def: "A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a seed. Seed dormancy is a suspension of most physiological activity and growth in a seed, including the embryo contained therein, that can be reactivated. It often requires special conditions for reactivation, such as specific temperature, scarification, or leaching of inhibitors." [GOC:lr, GOC:PO_curators, ISBN:9781405139830, PO_REF:00009] synonym: "seed dormancy" RELATED [] xref: Wikipedia:Seed#Seed_dormancy_and_protection is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022611 ! dormancy process is_a: GO:0032501 ! multicellular organismal process is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0010431 ! seed maturation [Term] id: GO:0010164 name: response to cesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] synonym: "response to cesium" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010165 name: response to X-ray namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] synonym: "response to X-ray radiation stimulus" EXACT [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010166 name: wax metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] synonym: "wax metabolism" EXACT [] is_a: GO:1901568 ! fatty acid derivative metabolic process [Term] id: GO:0010167 name: response to nitrate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901698 ! response to nitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010168 name: ER body namespace: cellular_component def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] synonym: "endoplasmic reticulum body" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0010169 name: thioglucosidase complex namespace: cellular_component def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] synonym: "myrosinase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0010170 name: glucose-1-phosphate adenylyltransferase complex namespace: cellular_component def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] is_a: GO:0044424 ! intracellular part is_a: GO:1902503 ! adenylyltransferase complex [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the soma are generated and organized." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0010172 name: embryonic body morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the embryonic soma are generated and organized." [GOC:ems] is_a: GO:0010171 ! body morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010174 name: nucleoside transmembrane transporter activity, against a concentration gradient namespace: molecular_function def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] synonym: "concentrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0010175 name: sphingosine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amino alcohol sphingosine from one side of a membrane to the other." [GOC:tb] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0046624 ! sphingolipid transporter activity [Term] id: GO:0010176 name: homogentisate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + phytyl diphosphate + H+ = 2-methyl-6-phytyl-1,4-benzoquinone + CO2 + diphosphate. 2-methyl-6-phytyl-1,4-benzoquinone is also known as 2-methyl-6-phytylplastoquinol." [MetaCyc:RXN-2541, PMID:14512521] xref: KEGG:R07500 xref: MetaCyc:RXN-2541 is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010177 name: 2-(2'-methylthio)ethylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-4-methylthiobutanoate + acetyl-CoA + H2O = 2-(2'-methylthio)ethylmalic-acid + coenzyme A + H+." [MetaCyc:RXN-2202] synonym: "methylthioalkylmalate synthase activity" BROAD [MetaCyc:RXN-2202] xref: EC:2.3.3.17 xref: MetaCyc:RXN-2202 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0010178 name: IAA-amino acid conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0010179 name: IAA-Ala conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-alanine + H2O = indole-3-acetate + L-alanine." [MetaCyc:RXN-2981] xref: MetaCyc:RXN-2981 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010180 name: thioglucosidase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb] synonym: "myrosinase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0010181 name: FMN binding namespace: molecular_function def: "Interacting selectively and non-covalently with flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] synonym: "flavin mononucleotide binding" EXACT [] is_a: GO:0032553 ! ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0010182 name: sugar mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] synonym: "sugar mediated signalling" EXACT [] is_a: GO:0009756 ! carbohydrate mediated signaling [Term] id: GO:0010183 name: pollen tube guidance namespace: biological_process def: "The process in which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] is_a: GO:0022414 ! reproductive process is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0010184 name: cytokinin transport namespace: biological_process def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:lr] is_a: GO:0009914 ! hormone transport [Term] id: GO:0010185 name: regulation of cellular defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "regulation of cellular defence response" EXACT [] is_a: GO:0031347 ! regulation of defense response relationship: regulates GO:0006968 ! cellular defense response [Term] id: GO:0010186 name: positive regulation of cellular defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "activation of cellular defense response" NARROW [] synonym: "positive regulation of cellular defence response" EXACT [] synonym: "stimulation of cellular defense response" NARROW [] synonym: "up regulation of cellular defense response" EXACT [] synonym: "up-regulation of cellular defense response" EXACT [] synonym: "upregulation of cellular defense response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031349 ! positive regulation of defense response relationship: positively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0010187 name: negative regulation of seed germination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of seed germination." [GOC:tb] synonym: "down regulation of seed germination" EXACT [] synonym: "down-regulation of seed germination" EXACT [] synonym: "downregulation of seed germination" EXACT [] synonym: "inhibition of seed germination" NARROW [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048581 ! negative regulation of post-embryonic development relationship: negatively_regulates GO:0009845 ! seed germination [Term] id: GO:0010188 name: response to microbial phytotoxin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0010189 name: vitamin E biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] synonym: "alpha-tocopherol biosynthesis" NARROW [] synonym: "alpha-tocopherol biosynthetic process" NARROW [] synonym: "tocopherol biosynthesis" EXACT [] synonym: "tocopherol biosynthetic process" EXACT [] synonym: "vitamin E anabolism" EXACT [] synonym: "vitamin E biosynthesis" EXACT [] synonym: "vitamin E formation" EXACT [] synonym: "vitamin E synthesis" EXACT [] xref: MetaCyc:PWY-1422 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042360 ! vitamin E metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0010190 name: cytochrome b6f complex assembly namespace: biological_process def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] synonym: "cytochrome b6f complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0010191 name: mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] subset: goslim_pir synonym: "mucilage metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0010192 name: mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] synonym: "mucilage anabolism" EXACT [] synonym: "mucilage biosynthesis" EXACT [] synonym: "mucilage formation" EXACT [] synonym: "mucilage synthesis" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0010193 name: response to ozone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] is_a: GO:0000302 ! response to reactive oxygen species is_a: GO:0001101 ! response to acid chemical is_a: GO:0010035 ! response to inorganic substance is_a: GO:0042493 ! response to drug is_a: GO:0046677 ! response to antibiotic [Term] id: GO:0010194 name: obsolete microRNA metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it implies further processing of an end product rather than its production. synonym: "microRNA metabolic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010195 name: obsolete microRNA biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it represents a process that is not known to occur. synonym: "microRNA anabolism" EXACT [] synonym: "microRNA biosynthesis" EXACT [] synonym: "microRNA biosynthetic process" EXACT [] synonym: "microRNA formation" EXACT [] synonym: "microRNA synthesis" EXACT [] synonym: "miRNA biosynthesis" EXACT [] synonym: "miRNA biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010196 name: nonphotochemical quenching namespace: biological_process def: "The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is emitted as heat. This process helps maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783, PMID:10938857] is_a: GO:1990066 ! energy quenching [Term] id: GO:0010197 name: polar nucleus fusion namespace: biological_process def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0010198 name: synergid death namespace: biological_process alt_id: GO:0048470 def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] synonym: "synergid cell death" EXACT [] synonym: "synergid degeneration" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010623 ! programmed cell death involved in cell development relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010199 name: organ boundary specification between lateral organs and the meristem namespace: biological_process def: "The process in which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] is_a: GO:0090691 ! formation of plant organ boundary [Term] id: GO:0010200 name: response to chitin namespace: biological_process def: "A process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0042493 ! response to drug is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010201 name: response to continuous far red light stimulus by the high-irradiance response system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010218 ! response to far red light [Term] id: GO:0010202 name: response to low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0010114 ! response to red light [Term] id: GO:0010203 name: response to very low fluence red light stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010114 ! response to red light is_a: GO:0055122 ! response to very low light intensity stimulus [Term] id: GO:0010204 name: defense response signaling pathway, resistance gene-independent namespace: biological_process def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm] synonym: "defence response signaling pathway, resistance gene-independent" EXACT [] synonym: "defence response signalling pathway, resistance gene-independent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0007165 ! signal transduction [Term] id: GO:0010205 name: photoinhibition namespace: biological_process def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] synonym: "photosystem II inhibition" BROAD [] xref: Wikipedia:Photoinhibition is_a: GO:0009644 ! response to high light intensity is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0010206 name: photosystem II repair namespace: biological_process def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the photosystem II following photoinhibition." [GOC:sm] is_a: GO:0030091 ! protein repair relationship: part_of GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0010207 name: photosystem II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on the thylakoid membrane. The photosystem II complex consists of at least 20 polypeptides and around 80 cofactors in most organisms." [GOC:aa, GOC:pz] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0010208 name: pollen wall assembly namespace: biological_process def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0045229 ! external encapsulating structure organization relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010209 name: vacuolar sorting signal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0010210 name: IAA-Phe conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-phenylalanine + H2O = indole-3-acetate + phenylalanine." [GOC:syr] is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010211 name: IAA-Leu conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetyl-leucine + H2O = indole-3-acetate + L-leucine." [MetaCyc:RXN-2982] xref: MetaCyc:RXN-2982 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation [Term] id: GO:0010213 name: non-photoreactive DNA repair namespace: biological_process def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] synonym: "light-independent DNA repair" EXACT [GOC:syr] is_a: GO:0006281 ! DNA repair [Term] id: GO:0010214 name: seed coat development namespace: biological_process def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010215 name: cellulose microfibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730] synonym: "cellulose microfibril organisation" EXACT [GOC:curators] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0071668 ! plant-type cell wall assembly [Term] id: GO:0010216 name: maintenance of DNA methylation namespace: biological_process def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0010217 name: cellular aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah] synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055079 ! aluminum ion homeostasis [Term] id: GO:0010218 name: response to far red light namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] synonym: "response to far red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010219 name: regulation of vernalization response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0010048 ! vernalization response [Term] id: GO:0010220 name: positive regulation of vernalization response namespace: biological_process def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "activation of vernalization response" NARROW [] synonym: "stimulation of vernalization response" NARROW [] synonym: "up regulation of vernalization response" EXACT [] synonym: "up-regulation of vernalization response" EXACT [] synonym: "upregulation of vernalization response" EXACT [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010221 name: negative regulation of vernalization response namespace: biological_process def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "down regulation of vernalization response" EXACT [] synonym: "down-regulation of vernalization response" EXACT [] synonym: "downregulation of vernalization response" EXACT [] synonym: "inhibition of vernalization response" NARROW [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010222 name: stem vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010223 name: secondary shoot formation namespace: biological_process def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] synonym: "auxiliary shoot formation" RELATED [] synonym: "axillary shoot formation" RELATED [] synonym: "axillary shoot system formation" EXACT [] synonym: "shoot branching" RELATED [] is_a: GO:0001763 ! morphogenesis of a branching structure is_a: GO:0010346 ! shoot axis formation [Term] id: GO:0010224 name: response to UV-B namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 280 to 315 nm." [GOC:tb] synonym: "response to medium wave ultraviolet light stimulus" EXACT [] synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-B light stimulus" EXACT [] synonym: "response to UV-B radiation stimulus" EXACT [] synonym: "response to UVB light stimulus" EXACT [] synonym: "response to UVB radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010225 name: response to UV-C namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 280 nm." [GOC:tb] synonym: "response to germicidal ultraviolet light stimulus" EXACT [] synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] synonym: "response to shortwave ultraviolet light stimulus" EXACT [] synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-C light stimulus" EXACT [] synonym: "response to UV-C radiation stimulus" EXACT [] synonym: "response to UVC light stimulus" EXACT [] synonym: "response to UVC radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010226 name: response to lithium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010227 name: floral organ abscission namespace: biological_process def: "The controlled shedding of floral organs." [GOC:PO_curators, PMID:12972671, PO:0025395] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009838 ! abscission relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0010228 name: vegetative to reproductive phase transition of meristem namespace: biological_process def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] synonym: "flowering" RELATED [] synonym: "transition from vegetative to reproductive phase" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0009791 ! post-embryonic development relationship: part_of GO:0048608 ! reproductive structure development [Term] id: GO:0010229 name: inflorescence development namespace: biological_process def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0090567 ! reproductive shoot system development [Term] id: GO:0010230 name: alternative respiration namespace: biological_process def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] is_a: GO:0009060 ! aerobic respiration [Term] id: GO:0010231 name: maintenance of seed dormancy namespace: biological_process def: "Any process that maintains a seed in a dormant state." [ISBN:9781405139830, PMID:9580097] is_a: GO:0010162 ! seed dormancy process is_a: GO:0097437 ! maintenance of dormancy [Term] id: GO:0010232 name: vascular transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010233 name: phloem transport namespace: biological_process def: "The directed movement of substances, into, out of or within the phloem during long distance transport between source and sink tissues." [GOC:sm, PMID:19025382] is_a: GO:0010232 ! vascular transport [Term] id: GO:0010234 name: anther wall tapetum cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] synonym: "tapetal cell fate specification" BROAD [GOC:tb] is_a: GO:0001708 ! cell fate specification is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0048657 ! anther wall tapetum cell differentiation [Term] id: GO:0010235 name: guard mother cell cytokinesis namespace: biological_process def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] synonym: "guard mother cell division" EXACT [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010236 name: plastoquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] synonym: "plastoquinone anabolism" EXACT [] synonym: "plastoquinone biosynthesis" EXACT [] synonym: "plastoquinone formation" EXACT [] synonym: "plastoquinone synthesis" EXACT [] xref: MetaCyc:PWY-1581 is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0010238 name: response to proline namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043200 ! response to amino acid [Term] id: GO:0010239 name: chloroplast mRNA processing namespace: biological_process def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] is_a: GO:0006397 ! mRNA processing is_a: GO:0031425 ! chloroplast RNA processing [Term] id: GO:0010240 name: plastid pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] synonym: "dehydrogenase complex" BROAD [] is_a: GO:0044435 ! plastid part is_a: GO:0045254 ! pyruvate dehydrogenase complex [Term] id: GO:0010241 name: ent-kaurene oxidation to kaurenoic acid namespace: biological_process def: "The three successive oxidations of the 4-methyl group of ent-kaurene to form ent-kaur-16-en-19-oate, kaurenoic acid. This process may be carried out entirely by the enzyme ent-kaurene oxidase." [EC:1.14.13.78, GOC:tb] comment: Note that this term was in molecular function but was moved to biological process as it represents three successive reactions. synonym: "ent-kaurene oxidation to ent-kaur-16-en-19-oate" EXACT [] synonym: "ent-kaurene oxidation to ent-kaurenoate" EXACT [] synonym: "ent-kaurene oxidation to kaurenoic acid by ent-kaurene oxidase" EXACT [] xref: EC:1.14.13.78 is_a: GO:0033331 ! ent-kaurene metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0010242 name: oxygen evolving activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] synonym: "photosynthetic water oxidation" EXACT [] xref: MetaCyc:PSII-RXN xref: MetaCyc:RXN0-5265 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0010243 name: response to organonitrogen compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organonitrogen stimulus. An organonitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [CHEBI:35352, PMID:9869419] synonym: "response to organic nitrogen" EXACT [] is_a: GO:0010033 ! response to organic substance is_a: GO:1901698 ! response to nitrogen compound [Term] id: GO:0010244 name: response to low fluence blue light stimulus by blue low-fluence system namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] synonym: "response to low fluence blue light" BROAD [] synonym: "response to low fluence blue light by blf system" EXACT [] is_a: GO:0009637 ! response to blue light is_a: GO:0009645 ! response to low light intensity stimulus [Term] id: GO:0010245 name: radial microtubular system formation namespace: biological_process def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0010246 name: rhamnogalacturonan I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] synonym: "rhamnogalacturonan I anabolism" EXACT [] synonym: "rhamnogalacturonan I biosynthesis" EXACT [] synonym: "rhamnogalacturonan I formation" EXACT [] synonym: "rhamnogalacturonan I synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010247 name: detection of phosphate ion namespace: biological_process def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "phosphate ion detection" EXACT [] synonym: "phosphate ion perception" RELATED [] synonym: "phosphate ion sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010248 name: establishment or maintenance of transmembrane electrochemical gradient namespace: biological_process def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane by means of some agent such as a transporter or pore." [GOC:mah, GOC:sm] is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0010249 name: auxin conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] synonym: "auxin conjugate metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process [Term] id: GO:0010250 name: S-methylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] synonym: "S-methylmethionine anabolism" EXACT [] synonym: "S-methylmethionine biosynthesis" EXACT [] synonym: "S-methylmethionine formation" EXACT [] synonym: "S-methylmethionine synthesis" EXACT [] is_a: GO:0033477 ! S-methylmethionine metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0010252 name: auxin homeostasis namespace: biological_process def: "A homeostatic process that maintains an endogenous steady-state concentration of primary auxin, or constant level of auxin in a biological system, by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010253 name: UDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] synonym: "UDP-rhamnose anabolism" EXACT [] synonym: "UDP-rhamnose biosynthesis" EXACT [] synonym: "UDP-rhamnose formation" EXACT [] synonym: "UDP-rhamnose synthesis" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0033478 ! UDP-rhamnose metabolic process [Term] id: GO:0010254 name: nectary development namespace: biological_process def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010255 name: glucose mediated signaling pathway namespace: biological_process def: "The process in which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] synonym: "glucose mediated signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling relationship: part_of GO:0071333 ! cellular response to glucose stimulus [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] synonym: "endomembrane organization" EXACT [GOC:curators] synonym: "endomembrane system organisation" EXACT [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0010257 name: NADH dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010258 name: NADH dehydrogenase complex (plastoquinone) assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] is_a: GO:0010257 ! NADH dehydrogenase complex assembly [Term] id: GO:0010259 name: multicellular organism aging namespace: biological_process def: "An aging process that has as participant a whole multicellular organism. Multicellular organism aging includes loss of functions such as resistance to disease, homeostasis, and fertility, as well as wear and tear. Multicellular organisms aging includes processes like cellular senescence and organ senescence, but is more inclusive. May precede death (GO:0016265) of an organism and may succeed developmental maturation (GO:0021700)." [GOC:PO_curators] is_a: GO:0007275 ! multicellular organism development is_a: GO:0007568 ! aging [Term] id: GO:0010260 name: animal organ senescence namespace: biological_process alt_id: GO:0010261 def: "The process that occurs in an animal organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism." [GOC:tb] is_a: GO:0007568 ! aging relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0010262 name: somatic embryogenesis namespace: biological_process def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] is_a: GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010263 name: tricyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0010264 name: myo-inositol hexakisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [CHEBI:17401, PMID:16107538] synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] synonym: "myo-inositol hexakisphosphate formation" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] synonym: "phytate biosynthesis" EXACT [] synonym: "phytate biosynthetic process" EXACT [] is_a: GO:0032958 ! inositol phosphate biosynthetic process is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process [Term] id: GO:0010265 name: SCF complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] is_a: GO:0065003 ! protein-containing complex assembly [Term] id: GO:0010266 name: response to vitamin B1 namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] synonym: "response to thiamin" EXACT [] synonym: "response to thiamine" EXACT [] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033273 ! response to vitamin is_a: GO:0042493 ! response to drug [Term] id: GO:0010267 name: production of ta-siRNAs involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah] is_a: GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0010268 name: brassinosteroid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of brassinosteroids within an organism or cell." [PMID:15908602] is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0010269 name: response to selenium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010270 name: photosystem II oxygen evolving complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on a thylakoid membrane. The OEC protects the calcium-4 manganese-5 oxide cluster which is bound to the D1 and CP43 proteins. The exact protein composition of the OEC varies between cyanobacteria and plants, and in plants consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ." [GOC:aa, PMID:16282331] synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] is_a: GO:0010207 ! photosystem II assembly [Term] id: GO:0010271 name: regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] is_a: GO:0090056 ! regulation of chlorophyll metabolic process is_a: GO:1901404 ! regulation of tetrapyrrole catabolic process relationship: regulates GO:0015996 ! chlorophyll catabolic process [Term] id: GO:0010272 name: response to silver ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010273 name: detoxification of copper ion namespace: biological_process def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [GOC:kmv, PMID:16367966] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:1990169 ! stress response to copper ion [Term] id: GO:0010274 name: hydrotropism namespace: biological_process def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] xref: Wikipedia:Hydrotropism is_a: GO:0009606 ! tropism [Term] id: GO:0010275 name: NAD(P)H dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010276 name: phytol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytyl monophosphate + CDP + H+." [MetaCyc:RXN-7683] xref: EC:2.7.1 xref: MetaCyc:RXN-7683 is_a: GO:0016301 ! kinase activity [Term] id: GO:0010277 name: chlorophyllide a oxygenase [overall] activity namespace: molecular_function alt_id: GO:0046407 def: "Catalysis of the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+; and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] comment: This is a process composed of two reactions represented by the terms 'GO:0052606 : chlorophyllide a oxygenase activity' and 'GO:0052607 : 7-hydroxy-chlorophyllide a oxygenase activity'. synonym: "CAO activity" BROAD [EC:1.13.12.14] synonym: "chlorophyll a oxygenation activity" EXACT [] synonym: "chlorophyll b synthesis activity" EXACT [] synonym: "chlorophyll-b synthesis activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide a:oxygen 7-oxidoreduction activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenation activity" EXACT [EC:1.13.12.14] xref: EC:1.14.13.122 xref: RHEA:30359 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0010278 name: chloroplast outer membrane translocon namespace: cellular_component def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] is_a: GO:0044434 ! chloroplast part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010279 name: indole-3-acetic acid amido synthetase activity namespace: molecular_function def: "Catalysis of the reaction: indole-3-acetic acid + an amino acid = an indole-3-acetic acid amide conjugate." [PMID:15659623] synonym: "IAA amido synthetase activity" EXACT [] synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad] synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0010280 name: UDP-L-rhamnose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-glucose + NADPH + H+ = UDP-L-rhamnose + NADP+ + H2O." [MetaCyc:RXN-5482, PMID:14701918] synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] xref: MetaCyc:RXN-5482 is_a: GO:0016740 ! transferase activity [Term] id: GO:0010282 name: senescence-associated vacuole namespace: cellular_component def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] synonym: "senescence associated vacuole" EXACT [GOC:curators] is_a: GO:0000323 ! lytic vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0010283 name: pinoresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: pinoresinol + NADPH + H+ = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8678 xref: MetaCyc:RXN-8683 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010284 name: lariciresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: lariciresinol + NADPH + H+ = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] xref: MetaCyc:RXN-8679 xref: MetaCyc:RXN-8684 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010285 name: L,L-diaminopimelate aminotransferase activity namespace: molecular_function alt_id: GO:0043742 def: "Catalysis of the reaction: 2-oxoglutarate + LL-2,6-diaminopimelate = (S)-2,3,4,5-tetrahydrodipicolinate + L-glutamate + H(2)O + H(+)." [EC:2.6.1.83, RHEA:23988] synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] xref: EC:2.6.1.83 xref: KEGG:R07613 xref: MetaCyc:RXN-7737 xref: RHEA:23988 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010286 name: heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] synonym: "thermotolerance" RELATED [GOC:tb] is_a: GO:0009408 ! response to heat [Term] id: GO:0010287 name: plastoglobule namespace: cellular_component alt_id: GO:0010502 def: "A lipoprotein particle present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] synonym: "PG" EXACT [] synonym: "plastoglobuli" EXACT [] is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0010288 name: response to lead ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010289 name: homogalacturonan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of (1->4)-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] xref: MetaCyc:PWY-1061 is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0052325 ! cell wall pectin biosynthetic process [Term] id: GO:0010290 name: chlorophyll catabolite transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of a membrane to the other." [PMID:9681016] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0010291 name: carotene beta-ring hydroxylase activity namespace: molecular_function alt_id: GO:0042411 def: "Catalysis of the reaction: a carotene + a reduced electron acceptor + O2 = C3-hydroxylated carotene + an oxidized electron acceptor + H2O. This is a general reaction to represent the C3 hydroxylation of the beta ring of a carotene." [MetaCyc:MONOMER-12386, PMID:16492736] synonym: "beta-carotene hydroxylase activity" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0010292 name: GTP:GDP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] is_a: GO:0001409 ! guanine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0010293 name: abscisic aldehyde oxidase activity namespace: molecular_function alt_id: GO:0033725 def: "Catalysis of the reaction: (+)-abscisic aldehyde + H(2)O + O(2) = abscisate + H(2)O(2) + H(+)." [EC:1.2.3.14, RHEA:20529] synonym: "AAO3" RELATED [EC:1.2.3.14] synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] synonym: "AOdelta" RELATED [EC:1.2.3.14] xref: EC:1.2.3.14 xref: KEGG:R06957 xref: MetaCyc:1.2.3.14-RXN xref: RHEA:20529 is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0010294 name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + UDP-D-glucose = abscisic acid glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: MetaCyc:RXN-8155 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0010295 name: (+)-abscisic acid 8'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + H(+) + NADPH + O(2) = (+)-8'-hydroxyabscisate + H(2)O + NADP(+)." [EC:1.14.13.93, RHEA:12897] synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93] synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] xref: EC:1.14.13.93 xref: KEGG:R07202 xref: MetaCyc:1.14.13.93-RXN xref: RHEA:12897 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0010296 name: prenylcysteine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein C-terminal S-farnesyl-L-cysteine methyl ester + H2O = protein C-terminal S-farnesyl-L-cysteine + methanol + H+." [MetaCyc:RXN-8409, PMID:16870359] xref: EC:3.1.1 xref: MetaCyc:RXN-8409 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0010297 name: heteropolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with heteropolysaccharides. A heteropolysaccharide is a glycan composed of more than one type of monosaccharide residue." [PMID:16640603] synonym: "heteroglycan binding" EXACT [GOC:curators] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0010298 name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2 + H+." [MetaCyc:RXN-8275, PMID:16766671] xref: MetaCyc:RXN-8275 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0010299 name: detoxification of cobalt ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] is_a: GO:0061687 ! detoxification of inorganic compound relationship: part_of GO:0032025 ! response to cobalt ion [Term] id: GO:0010301 name: xanthoxin dehydrogenase activity namespace: molecular_function alt_id: GO:0033710 def: "Catalysis of the reaction: NAD(+) + xanthoxin = (+)-abscisic aldehyde + H(+) + NADH." [EC:1.1.1.288, RHEA:12548] synonym: "ABA2" RELATED [EC:1.1.1.288] synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] xref: EC:1.1.1.288 xref: KEGG:R06954 xref: MetaCyc:1.1.1.288-RXN xref: RHEA:12548 is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0010303 name: limit dextrinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] synonym: "R-enzyme" RELATED [EC:3.2.1.142] xref: EC:3.2.1.142 xref: MetaCyc:3.2.1.10-RXN xref: MetaCyc:3.2.1.142-RXN xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0010304 name: PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880] synonym: "LHCII catabolism" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0010305 name: leaf vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010306 name: rhamnogalacturonan II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process is_a: GO:0052325 ! cell wall pectin biosynthetic process [Term] id: GO:0010307 name: acetylglutamate kinase regulator activity namespace: molecular_function def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0010308 name: acireductone dioxygenase (Ni2+-requiring) activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 3-(methylthio)propanoate + CO + formate." [EC:1.13.11.53, RHEA:14161] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "ARD activity" RELATED [EC:1.13.11.53] synonym: "E-2 activity" RELATED [EC:1.13.11.53] xref: EC:1.13.11.53 xref: KEGG:R07363 xref: MetaCyc:R146-RXN xref: RHEA:14161 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010309 name: acireductone dioxygenase [iron(II)-requiring] activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O(2) = 4-methylthio-2-oxobutanoate + formate + H(+)." [EC:1.13.11.54, RHEA:24504] synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] synonym: "aci-reductone dioxygenase" BROAD [] synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] synonym: "ARD'" RELATED [] synonym: "ARD1" RELATED [] synonym: "E-2'" RELATED [] xref: EC:1.13.11.54 xref: KEGG:R07364 xref: MetaCyc:R147-RXN xref: reactome:R-HSA-1237119 "Acireductone is oxidized to MOB" xref: RHEA:24504 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010310 name: regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] synonym: "regulation of hydrogen peroxide metabolism" EXACT [] is_a: GO:0051193 ! regulation of cofactor metabolic process is_a: GO:2000377 ! regulation of reactive oxygen species metabolic process relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010311 name: lateral root formation namespace: biological_process alt_id: GO:0010386 def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators, PMID:17259263] synonym: "lateral root primordium development" EXACT [] is_a: GO:0009791 ! post-embryonic development is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010102 ! lateral root morphogenesis [Term] id: GO:0010312 name: detoxification of zinc ion namespace: biological_process def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] is_a: GO:0098754 ! detoxification relationship: part_of GO:1990359 ! stress response to zinc ion [Term] id: GO:0010313 name: phytochrome binding namespace: molecular_function def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102] is_a: GO:0005515 ! protein binding [Term] id: GO:0010314 name: phosphatidylinositol-5-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0010315 name: auxin efflux namespace: biological_process def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators, PMID:16990790] synonym: "auxin export" EXACT [] is_a: GO:0010928 ! regulation of auxin mediated signaling pathway is_a: GO:0060918 ! auxin transport [Term] id: GO:0010316 name: pyrophosphate-dependent phosphofructokinase complex namespace: cellular_component def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] subset: goslim_pir synonym: "PFK complex" RELATED [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0010317 name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex namespace: cellular_component def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, alpha-subunit" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010318 name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex namespace: cellular_component def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, beta-subunit" RELATED [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010319 name: stromule namespace: cellular_component def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] synonym: "Stroma-filled tubule" RELATED [] xref: Wikipedia:Stromule is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0010320 name: obsolete arginine/lysine endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. synonym: "arginine/lysine endopeptidase activity" EXACT [] is_obsolete: true consider: GO:0004175 consider: GO:0004197 [Term] id: GO:0010321 name: regulation of vegetative phase change namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] is_a: GO:0048580 ! regulation of post-embryonic development relationship: regulates GO:0010050 ! vegetative phase change [Term] id: GO:0010322 name: regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [Term] id: GO:0010323 name: negative regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] synonym: "negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway [Term] id: GO:0010324 name: membrane invagination namespace: biological_process alt_id: GO:1902534 def: "The infolding of a membrane." [GOC:tb] subset: goslim_yeast synonym: "single-organism membrane invagination" RELATED [] is_a: GO:0061024 ! membrane organization [Term] id: GO:0010325 name: raffinose family oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process [Term] id: GO:0010326 name: methionine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: methionine + a 2-oxo acid = 2-oxo-4-methylthiobutanoate + an amino acid." [MetaCyc:RXN-2201, PMID:17056707] xref: MetaCyc:RXN-2201 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010327 name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] synonym: "hexenol acetyltransferase" RELATED [] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0010328 name: auxin influx transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] synonym: "auxin influx facilitator" RELATED [] is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0010329 name: auxin efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] synonym: "auxin efflux carrier" RELATED [] synonym: "auxin efflux facilitator" RELATED [] is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0080161 ! auxin transmembrane transporter activity [Term] id: GO:0010330 name: cellulose synthase complex namespace: cellular_component def: "A large, multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238, PMID:18485800, PMID:21307367] synonym: "CESA complex" EXACT [] is_a: GO:1990234 ! transferase complex [Term] id: GO:0010331 name: gibberellin binding namespace: molecular_function def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] synonym: "gibberellic acid receptor" RELATED [] synonym: "gibberellin receptor" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010333 name: terpene synthase activity namespace: molecular_function def: "Catalysis of the formation of cyclic terpenes through the cyclization of linear terpenes (e.g. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP) containing varying numbers of isoprene units." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0010334 name: sesquiterpene synthase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate = a sesquiterpene + diphosphate. Sesquiterpenes are terpenes containing three isoprene units, i.e. 15 carbons." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0010335 name: response to non-ionic osmotic stress namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0010336 name: gibberellic acid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] synonym: "gibberellin homeostasis" BROAD [] is_a: GO:0055081 ! anion homeostasis is_a: GO:0055088 ! lipid homeostasis [Term] id: GO:0010337 name: regulation of salicylic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] synonym: "regulation of salicylic acid metabolism" RELATED [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010338 name: leaf formation namespace: biological_process def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0099402 ! plant organ development is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010339 name: external side of cell wall namespace: cellular_component def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0010340 name: carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0010341 name: gibberellin carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a gibberellin = S-adenosyl-L-homocysteine + a gibberellin methyl ester." [PMID:17220201] is_a: GO:0010340 ! carboxyl-O-methyltransferase activity [Term] id: GO:0010342 name: endosperm cellularization namespace: biological_process def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] synonym: "cellularization of endosperm" EXACT [] is_a: GO:0007349 ! cellularization [Term] id: GO:0010343 name: singlet oxygen-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:17075038] synonym: "light-dependent programmed cell death" BROAD [] synonym: "programmed cell death in response to singlet oxygen" EXACT [] is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species relationship: part_of GO:0071452 ! cellular response to singlet oxygen [Term] id: GO:0010344 name: seed oilbody biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a seed oilbody. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495] synonym: "oleosome biogenesis" RELATED [] synonym: "seed oil body organization" EXACT [] synonym: "spherosome biogenesis" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:0044085 ! cellular component biogenesis relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010345 name: suberin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] xref: MetaCyc:PWY-1121 is_a: GO:0009699 ! phenylpropanoid biosynthetic process [Term] id: GO:0010346 name: shoot axis formation namespace: biological_process def: "The process that gives rise to a shoot axis. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] synonym: "shoot formation" RELATED [] is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010016 ! shoot system morphogenesis [Term] id: GO:0010347 name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: MetaCyc:RXNQT-4142 is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0010348 name: lithium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] synonym: "lithium:hydrogen antiporter activity" EXACT [] is_a: GO:0005451 ! monovalent cation:proton antiporter activity [Term] id: GO:0010349 name: L-galactose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: MetaCyc:RXN-1884 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0010350 name: cellular response to magnesium starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010351 name: lithium ion transport namespace: biological_process def: "The directed movement of lithium ion into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [PMID:17270011] synonym: "lithium transport" EXACT [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0010352 name: lithium ion export across the plasma membrane namespace: biological_process def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] synonym: "lithium export" EXACT [] synonym: "lithium ion efflux" RELATED [] synonym: "lithium ion export" RELATED [] is_a: GO:0010351 ! lithium ion transport is_a: GO:0098662 ! inorganic cation transmembrane transport is_a: GO:0140115 ! export across plasma membrane [Term] id: GO:0010353 name: response to trehalose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] synonym: "response to trehalose stimulus" EXACT [GOC:dos] is_a: GO:0034285 ! response to disaccharide [Term] id: GO:0010354 name: homogentisate prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0010355 name: homogentisate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate = 2-methyl-6-farnesylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010356 name: homogentisate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate = 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010357 name: homogentisate solanesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + all-trans-nonaprenyl diphosphate + 3 H+ = 2-methyl-6-solanyl-1,4-benzoquinonone + CO2 + diphosphate. 2-methyl-6-solanyl-1,4-benzoquinonone is also known as 2-methyl-6-solanesylplastoquinol and all-trans-nonaprenyl diphosphate as solanesyl diphosphate." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010358 name: leaf shaping namespace: biological_process def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] synonym: "leaf structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010359 name: regulation of anion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:1903959 ! regulation of anion transmembrane transport [Term] id: GO:0010360 name: negative regulation of anion channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity is_a: GO:1903960 ! negative regulation of anion transmembrane transport [Term] id: GO:0010361 name: regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010359 ! regulation of anion channel activity [Term] id: GO:0010362 name: negative regulation of anion channel activity by blue light namespace: biological_process def: "Any process in which blue light stops, prevents, or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] synonym: "inhibition by blue light of anion channel activity" NARROW [] synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:0010361 ! regulation of anion channel activity by blue light [Term] id: GO:0010363 name: regulation of plant-type hypersensitive response namespace: biological_process def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "regulation of HR" EXACT [] synonym: "regulation of HR-PCD" EXACT [] synonym: "regulation of plant hypersensitive response" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0010364 name: regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:1900911 ! regulation of olefin biosynthetic process relationship: regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010365 name: positive regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:1900913 ! positive regulation of olefin biosynthetic process relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010366 name: negative regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:1900912 ! negative regulation of olefin biosynthetic process relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010367 name: extracellular isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] is_a: GO:0043033 ! isoamylase complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0010368 name: chloroplast isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] is_a: GO:0043033 ! isoamylase complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0010369 name: chromocenter namespace: cellular_component def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] is_a: GO:0098687 ! chromosomal region [Term] id: GO:0010370 name: perinucleolar chromocenter namespace: cellular_component def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] is_a: GO:0010369 ! chromocenter [Term] id: GO:0010371 name: regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process relationship: regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010372 name: positive regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "positive regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010373 name: negative regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010374 name: stomatal complex development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0009791 ! post-embryonic development is_a: GO:0090558 ! plant epidermis development [Term] id: GO:0010375 name: stomatal complex patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0003002 ! regionalization [Term] id: GO:0010376 name: stomatal complex formation namespace: biological_process def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010377 name: guard cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] synonym: "stomatal cell fate commitment" RELATED [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010378 name: temperature compensation of the circadian clock namespace: biological_process def: "The process in which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] synonym: "regulation of the circadian clock by temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0010379 name: phaseic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271] xref: MetaCyc:PWY-5271 is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0010380 name: regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] is_a: GO:0090056 ! regulation of chlorophyll metabolic process is_a: GO:1901463 ! regulation of tetrapyrrole biosynthetic process relationship: regulates GO:0015995 ! chlorophyll biosynthetic process [Term] id: GO:0010381 name: peroxisome-chloroplast membrane tethering namespace: biological_process def: "The attachment of a peroxisome to a chloroplast via molecular tethers that physically bridge their respective membranes and attach them to each other. The tethering may facilitate exchange of metabolites between the organelles." [PMID:17215364] synonym: "attachment of peroxisome to chloroplast" EXACT [] is_a: GO:0140056 ! organelle localization by membrane tethering [Term] id: GO:0010383 name: cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010384 name: cell wall proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010385 name: double-stranded methylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Methylation of cytosine or adenine in DNA is an important mechanism for establishing stable heritable epigenetic marks." [GOC:imk, PMID:17242155] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0010387 name: COP9 signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a COP9 signalosome." [PMID:17307927] synonym: "signalosome assembly" BROAD [GOC:krc] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0010389 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle, PMID:17329565] synonym: "regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902749 ! regulation of cell cycle G2/M phase transition relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010390 name: histone monoubiquitination namespace: biological_process def: "The modification of histones by addition of a single ubiquitin group." [PMID:17329563] is_a: GO:0006513 ! protein monoubiquitination is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0010391 name: glucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] synonym: "glucomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0010392 name: galactoglucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] synonym: "galactoglucomannan metabolism" RELATED [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010393 name: galacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] synonym: "galacturonan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0010394 name: homogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] synonym: "homogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010395 name: rhamnogalacturonan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] synonym: "RGI metabolism" RELATED [] synonym: "rhamnogalacturonan I metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010396 name: rhamnogalacturonan II metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010397 name: apiogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(1->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] synonym: "apiogalacturonan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0010398 name: xylogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] synonym: "xylogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010399 name: rhamnogalacturonan I backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010400 name: rhamnogalacturonan I side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010401 name: pectic galactan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic galactan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010402 name: pectic arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinan, a polymer with an alpha-(1->5)-linked L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010403 name: pectic arabinogalactan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1,4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinogalactan I metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010404 name: cell wall hydroxyproline-rich glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] is_a: GO:0010384 ! cell wall proteoglycan metabolic process [Term] id: GO:0010405 name: arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] synonym: "arabinogalactan protein metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010406 name: classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] synonym: "classical-arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010407 name: non-classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] synonym: "non-classical arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010408 name: fasciclin-like arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010409 name: extensin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] synonym: "extensin metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010410 name: hemicellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] synonym: "hemicellulose metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010411 name: xyloglucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] synonym: "xyloglucan metabolism" EXACT [GOC:obol] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0010412 name: mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] synonym: "mannan metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010413 name: glucuronoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] synonym: "glucuronoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010414 name: glucuronoarabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] synonym: "glucuronoarabinoxylan metabolism" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0010416 ! arabinoxylan-containing compound metabolic process [Term] id: GO:0010415 name: unsubstituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] synonym: "unsubstituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0010416 name: arabinoxylan-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an arabinoxylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] synonym: "arabinoxylan metabolic process" RELATED [] synonym: "arabinoxylan metabolism" RELATED [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010417 name: glucuronoxylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] synonym: "glucuronoxylan anabolism" EXACT [] synonym: "glucuronoxylan biosynthesis" EXACT [] synonym: "glucuronoxylan formation" EXACT [] synonym: "glucuronoxylan synthesis" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0045492 ! xylan biosynthetic process [Term] id: GO:0010418 name: rhamnogalacturonan II backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010419 name: rhamnogalacturonan II side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010420 name: polyprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate + H+." [PMID:9628017] xref: MetaCyc:RXN-9281 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0010421 name: hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [GOC:mtg_apoptosis, PMID:16036580] synonym: "programmed cell death in response to hydrogen peroxide" EXACT [] is_a: GO:0036474 ! cell death in response to hydrogen peroxide is_a: GO:0097468 ! programmed cell death in response to reactive oxygen species [Term] id: GO:0010422 name: regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010423 name: negative regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010424 name: DNA methylation on cytosine within a CG sequence namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010425 name: DNA methylation on cytosine within a CNG sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010426 name: DNA methylation on cytosine within a CHH sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600] synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah] synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010427 name: abscisic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] synonym: "ABA binding" RELATED [] synonym: "abscisate binding" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0042562 ! hormone binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0010428 name: methyl-CpNpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010429 name: methyl-CpNpN binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010430 name: fatty acid omega-oxidation namespace: biological_process def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574] xref: MetaCyc:PWY-2724 is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0010431 name: seed maturation namespace: biological_process def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048609 ! multicellular organismal reproductive process is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010432 name: bract development namespace: biological_process def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048827 ! phyllome development [Term] id: GO:0010433 name: bract morphogenesis namespace: biological_process def: "The process in which the anatomical structure of a bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:1905392 ! plant organ morphogenesis relationship: part_of GO:0010432 ! bract development [Term] id: GO:0010434 name: bract formation namespace: biological_process def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:1905393 ! plant organ formation relationship: part_of GO:0010433 ! bract morphogenesis [Term] id: GO:0010435 name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid + coenzyme A = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoyl-CoA + H+. 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid is also known as OPC-8:0." [PMID:16963437] synonym: "3-oxo-2-(2'-[Z]-pentenyl)cyclopentane-1-octanoate CoA ligase activity" EXACT [MetaCyc:RXN-10695] synonym: "3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity" EXACT [] synonym: "OPC-8:0 CoA ligase activity" EXACT [] xref: EC:6.2.1 xref: MetaCyc:RXN-10695 is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0010436 name: carotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] synonym: "carotenoid-cleaving dioxygenase" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010437 name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0010438 name: cellular response to sulfur starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010439 name: regulation of glucosinolate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process relationship: regulates GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0010440 name: stomatal lineage progression namespace: biological_process def: "The process in which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010441 name: guard cell development namespace: biological_process def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010442 name: guard cell morphogenesis namespace: biological_process def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] synonym: "guard cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0090698 ! post-embryonic plant morphogenesis relationship: part_of GO:0010441 ! guard cell development [Term] id: GO:0010443 name: meristemoid mother cell division namespace: biological_process def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] synonym: "meristemoid division" RELATED [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010444 name: guard mother cell differentiation namespace: biological_process def: "The process in which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] is_a: GO:0090627 ! plant epidermal cell differentiation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010445 name: nuclear dicing body namespace: cellular_component def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] synonym: "D body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0010446 name: response to alkaline pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH] synonym: "response to alkalinity" BROAD [] synonym: "response to basic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010447 name: response to acidic pH namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution." [GOC:go_curators, GOC:tb, http://en.wikipedia.org/wiki/PH] comment: This term should be used to annotate instances where a cell or organism is responding to a chemical that is playing the role of an acid (e.g. proton donor) and therefore lowering the pH. If instead you wish to describe a response to a specific acid as a chemical, such as the anion portion of glutamate, please annotate to the appropriate child of GO:0001101 'response to acid chemical'. synonym: "response to acidity" BROAD [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010448 name: vegetative meristem growth namespace: biological_process def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] is_a: GO:0035266 ! meristem growth is_a: GO:0080186 ! developmental vegetative growth relationship: part_of GO:0048367 ! shoot system development [Term] id: GO:0010449 name: root meristem growth namespace: biological_process def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048364 ! root development [Term] id: GO:0010450 name: inflorescence meristem growth namespace: biological_process def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0010451 name: floral meristem growth namespace: biological_process def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0035266 ! meristem growth relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010452 name: histone H3-K36 methylation namespace: biological_process def: "The modification of histone H3 by addition of one or more methyl groups to lysine at position 36 of the histone." [GOC:pr, GOC:tb] synonym: "histone H3 K36 methylation" EXACT [GOC:tb] synonym: "histone H3K36me" EXACT [GOC:tb] synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010456 name: cell proliferation in dorsal spinal cord namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] is_a: GO:0061351 ! neural precursor cell proliferation [Term] id: GO:0010457 name: centriole-centriole cohesion namespace: biological_process def: "The cell cycle process in which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007098 ! centrosome cycle [Term] id: GO:0010458 name: exit from mitosis namespace: biological_process def: "The cell cycle transition where a cell leaves M phase and enters a new G1 phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "exit from mitotic division" EXACT [] synonym: "mitotic exit" EXACT [] is_a: GO:0044772 ! mitotic cell cycle phase transition relationship: part_of GO:0140014 ! mitotic nuclear division [Term] id: GO:0010459 name: negative regulation of heart rate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0010460 name: positive regulation of heart rate namespace: biological_process def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0010461 name: light-activated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] is_a: GO:0005216 ! ion channel activity [Term] id: GO:0010462 name: regulation of light-activated voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:1901385 ! regulation of voltage-gated calcium channel activity [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell population proliferation relationship: regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0010465 name: nerve growth factor receptor activity namespace: molecular_function def: "Combining with nerve growth factor (NGF), to prevent apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] synonym: "beta-nerve growth factor receptor activity" EXACT [PR:000011194] synonym: "NGF receptor activity" EXACT [PR:000011194] is_a: GO:0005030 ! neurotrophin receptor activity [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process in which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: goslim_flybase_ribbon xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This class covers any process that regulates the rate of production of a mature gene product, and so includes processes that regulate that rate by regulating the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that regulates the level, stability or availability of mRNA or circRNA for translation and thereby regulates the rate of production of the encoded protein via translation. synonym: "regulation of gene product expression" RELATED [GOC:curators] synonym: "regulation of protein expression" NARROW [GOC:curators] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010469 name: regulation of signaling receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] synonym: "regulation of receptor activity" BROAD [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0007369 ! gastrulation [Term] id: GO:0010471 name: GDP-galactose:mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-mannose 1-phosphate = GDP-alpha-D-mannose + alpha-L-galactose-1-phosphate." [MetaCyc:RXN4FS-12, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:mannose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-12] xref: MetaCyc:RXN4FS-12 is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0010472 name: GDP-galactose:glucose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + alpha-D-glucose 1-phosphate = alpha-L-galactose-1-phosphate + GDP-alpha-D-glucose." [MetaCyc:RXN4FS-13, PMID:17485667] synonym: "GDP-L-galactose phosphorylase activity" BROAD [MetaCyc:AT4G26850-MONOMER] synonym: "GDP-L-galactose:glucose-1-phosphate guanylyltransferase activity" EXACT [MetaCyc:RXN4FS-13] xref: MetaCyc:RXN4FS-13 is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010473 name: GDP-galactose:myoinositol-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-galactose + myo-inositol 1-phosphate = alpha-L-galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010474 name: glucose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] synonym: "GDP:glucose-1-phosphate guanyltransferase activity" EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010475 name: galactose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] synonym: "GDP:galactose-1-phosphate guanyltransferase activity" EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010476 name: gibberellin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] synonym: "gibberellin-mediated signalling" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway relationship: part_of GO:0071370 ! cellular response to gibberellin stimulus [Term] id: GO:0010477 name: response to sulfur dioxide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] is_a: GO:0010035 ! response to inorganic substance is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0010478 name: chlororespiration namespace: biological_process def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0010479 name: stele development namespace: biological_process def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048364 ! root development [Term] id: GO:0010480 name: microsporocyte differentiation namespace: biological_process def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248, PMID:16751349] synonym: "pollen mother cell differentiation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048533 ! sporocyte differentiation relationship: part_of GO:0048653 ! anther development [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0010481 ! epidermal cell division [Term] id: GO:0010483 name: pollen tube reception namespace: biological_process def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] is_a: GO:0044703 ! multi-organism reproductive process is_a: GO:0051703 ! intraspecies interaction between organisms relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010484 name: H3 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 = CoA + acetyl-histone H3." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010485 name: H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H4 = CoA + acetyl-histone H4." [EC:2.3.1.48] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010486 name: manganese:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] synonym: "manganese:hydrogen antiporter activity" EXACT [] is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0051139 ! metal ion:proton antiporter activity [Term] id: GO:0010487 name: thermospermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methioninamine + spermidine = S-methyl-5'-thioadenosine + thermospermine + H+." [EC:2.5.1.79, MetaCyc:RXN-11190, PMID:17560575] xref: EC:2.5.1.79 xref: MetaCyc:RXN-11190 xref: RHEA:30515 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0010488 name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0010489 name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose = UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0010490 name: UDP-4-keto-rhamnose-4-keto-reductase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH = UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0010491 name: UTP:arabinose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0010492 name: maintenance of shoot apical meristem identity namespace: biological_process def: "The process in which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010493 name: Lewis a epitope biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-(1->4)[Gal-beta-(1->3)]GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] synonym: "LE A biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0010494 name: cytoplasmic stress granule namespace: cellular_component def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [GOC:ans, PMID:17284590, PMID:17601829, PMID:17967451, PMID:20368989] synonym: "cytoplasmic mRNP granule" EXACT [] synonym: "stress granule" EXACT [] xref: Wikipedia:Stress_granule is_a: GO:0036464 ! cytoplasmic ribonucleoprotein granule [Term] id: GO:0010495 name: long-distance posttranscriptional gene silencing namespace: biological_process def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0010496 name: intercellular transport namespace: biological_process alt_id: GO:1902585 def: "The movement of substances between cells." [GOC:dhl] synonym: "single organism intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism intercellular transport" RELATED [] is_a: GO:0006810 ! transport is_a: GO:0009987 ! cellular process [Term] id: GO:0010497 name: plasmodesmata-mediated intercellular transport namespace: biological_process alt_id: GO:1902587 def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] synonym: "plasmodesma-mediated intercellular transport" EXACT [] synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] synonym: "single organism plasmodesmata-mediated intercellular transport" RELATED [GOC:TermGenie] synonym: "single-organism plasmodesmata-mediated intercellular transport" RELATED [] is_a: GO:0010496 ! intercellular transport [Term] id: GO:0010498 name: proteasomal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] synonym: "proteasome-mediated protein catabolic process" EXACT [] synonym: "proteasome-mediated protein catabolism" EXACT [] is_a: GO:0030163 ! protein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0010499 name: proteasomal ubiquitin-independent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0010500 name: transmitting tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] is_a: GO:0048467 ! gynoecium development [Term] id: GO:0010501 name: RNA secondary structure unwinding namespace: biological_process def: "The process in which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] synonym: "RNA duplex unwinding" EXACT [GOC:ecd] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0010503 name: obsolete negative regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010504 name: obsolete regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010505 name: obsolete positive regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. is_obsolete: true [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0006914 ! autophagy [Term] id: GO:0010507 name: negative regulation of autophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031330 ! negative regulation of cellular catabolic process relationship: negatively_regulates GO:0006914 ! autophagy [Term] id: GO:0010508 name: positive regulation of autophagy namespace: biological_process def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process in which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031331 ! positive regulation of cellular catabolic process relationship: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0010509 name: polyamine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010510 name: regulation of acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] is_a: GO:0050812 ! regulation of acyl-CoA biosynthetic process relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0010511 name: regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010512 name: negative regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010513 name: positive regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010514 name: induction of conjugation with cellular fusion namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0010515 name: negative regulation of induction of conjugation with cellular fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency or rate of initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0010516 name: negative regulation of cellular response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation [Term] id: GO:0010517 name: regulation of phospholipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060191 ! regulation of lipase activity [Term] id: GO:0010518 name: positive regulation of phospholipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060193 ! positive regulation of lipase activity [Term] id: GO:0010519 name: negative regulation of phospholipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060192 ! negative regulation of lipase activity [Term] id: GO:0010520 name: regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0060631 ! regulation of meiosis I relationship: regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010521 name: telomerase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0010522 name: regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051924 ! regulation of calcium ion transport is_a: GO:0060341 ! regulation of cellular localization is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010523 name: negative regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051926 ! negative regulation of calcium ion transport relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010524 name: positive regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0007204 ! positive regulation of cytosolic calcium ion concentration is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051928 ! positive regulation of calcium ion transport relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010525 name: regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition relationship: regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010526 name: negative regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010529 ! negative regulation of transposition relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010527 name: positive regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010530 ! positive regulation of transposition relationship: positively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010528 name: regulation of transposition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0032196 ! transposition [Term] id: GO:0010529 name: negative regulation of transposition namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0032196 ! transposition [Term] id: GO:0010530 name: positive regulation of transposition namespace: biological_process def: "Any process that increases the frequency, rate or extent of transposition. Transposition results in the movement of discrete segments of DNA between nonhomologous sites." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0032196 ! transposition [Term] id: GO:0010533 name: regulation of activation of Janus kinase activity namespace: biological_process alt_id: GO:0010532 alt_id: GO:0010534 def: "Any process that modulates the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:17190829, PMID:9135582] synonym: "regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "regulation of activation of JAK1 kinase activity" NARROW [] synonym: "regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of activation of JAK2 kinase activity" NARROW [] synonym: "regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0046425 ! regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050730 ! regulation of peptidyl-tyrosine phosphorylation relationship: regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010536 name: positive regulation of activation of Janus kinase activity namespace: biological_process alt_id: GO:0010535 alt_id: GO:0010537 def: "Any process that increases the frequency or rate of activation of JAK (Janus Activated Kinase) protein. The activation of JAK protein is the process of introducing a phosphate group to a tyrosine residue of a JAK (Janus Activated Kinase) protein, thereby activating it." [GOC:dph, GOC:tb, PMID:9135582] synonym: "positive regulation of activation of JAK protein" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of activation of JAK1 kinase activity" NARROW [] synonym: "positive regulation of activation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of activation of JAK2 kinase activity" NARROW [] synonym: "positive regulation of activation of JAK2 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK protein" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK1 protein" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of tyrosine phosphorylation of JAK2 protein" NARROW [GOC:dph, GOC:tb] is_a: GO:0010533 ! regulation of activation of Janus kinase activity is_a: GO:0045860 ! positive regulation of protein kinase activity is_a: GO:0046427 ! positive regulation of receptor signaling pathway via JAK-STAT is_a: GO:0050731 ! positive regulation of peptidyl-tyrosine phosphorylation relationship: positively_regulates GO:0042976 ! activation of Janus kinase activity [Term] id: GO:0010538 name: obsolete Hsp27 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb, PMID:11546764] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. synonym: "Hsp27 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010539 name: obsolete Hsp27 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp27 molecular chaperone." [GOC:dph, GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp27 protein activity'. synonym: "Hsp27 protein inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0051008 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010540 name: basipetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the apex to base of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010541 name: acropetal auxin transport namespace: biological_process def: "The unidirectional movement of auxin from the base towards the apex of an organ, including the shoot, leaf, primary root, or lateral root." [PMID:10677441] is_a: GO:0009926 ! auxin polar transport [Term] id: GO:0010542 name: nitrate efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrate from the inside of the cell to the outside of the cell across a membrane." [GOC:mah] is_a: GO:0015513 ! high-affinity secondary active nitrite transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0010543 name: regulation of platelet activation namespace: biological_process def: "Any process that modulates the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0030168 ! platelet activation [Term] id: GO:0010544 name: negative regulation of platelet activation namespace: biological_process def: "Any process that decreases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030195 ! negative regulation of blood coagulation is_a: GO:0050866 ! negative regulation of cell activation relationship: negatively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010545 name: obsolete Hsp90 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsp90." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. synonym: "Hsp90 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010546 name: obsolete Hsp90 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the Hsp90 molecular chaperone." [GOC:dph, GOC:tb, PMID:11146632] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp90 protein activity'. synonym: "Hsp90 protein inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0051879 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0010547 name: thylakoid membrane disassembly namespace: biological_process def: "The controlled breakdown of the thylakoid membrane in the context of a normal process." [GOC:dph, GOC:tb, PMID:17416733] synonym: "thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010027 ! thylakoid membrane organization is_a: GO:0030397 ! membrane disassembly [Term] id: GO:0010548 name: regulation of thylakoid membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of thylakoid membrane disassembly." [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of thylakoid membrane degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010549 ! regulation of membrane disassembly is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0010547 ! thylakoid membrane disassembly [Term] id: GO:0010549 name: regulation of membrane disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of membrane disassembly." [GOC:dph, GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0030397 ! membrane disassembly [Term] id: GO:0010550 name: regulation of PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:dph, GOC:tb] synonym: "regulation of LHCII catabolism" EXACT [GOC:dph, GOC:tb, PMID:17416733] synonym: "regulation of LHCII degradation" EXACT [PMID:17416733] is_a: GO:1903362 ! regulation of cellular protein catabolic process relationship: regulates GO:0010304 ! PSII associated light-harvesting complex II catabolic process [Term] id: GO:0010555 name: response to mannitol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mannitol stimulus." [PMID:17999646] synonym: "response to mannitol stimulus" EXACT [GOC:dos] is_a: GO:0009743 ! response to carbohydrate [Term] id: GO:0010556 name: regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010557 name: positive regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010604 ! positive regulation of macromolecule metabolic process relationship: positively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010558 name: negative regulation of macromolecule biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010605 ! negative regulation of macromolecule metabolic process relationship: negatively_regulates GO:0009059 ! macromolecule biosynthetic process [Term] id: GO:0010559 name: regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:1903018 ! regulation of glycoprotein metabolic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010560 name: positive regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903020 ! positive regulation of glycoprotein metabolic process relationship: positively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010561 name: negative regulation of glycoprotein biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process is_a: GO:1903019 ! negative regulation of glycoprotein metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0010562 name: positive regulation of phosphorus metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: positively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010563 name: negative regulation of phosphorus metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving phosphorus or compounds containing phosphorus." [GOC:dph, GOC:tb] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: negatively_regulates GO:0006793 ! phosphorus metabolic process [Term] id: GO:0010564 name: regulation of cell cycle process namespace: biological_process def: "Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle relationship: regulates GO:0022402 ! cell cycle process [Term] id: GO:0010565 name: regulation of cellular ketone metabolic process namespace: biological_process def: "Any process that modulates the chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0010566 name: regulation of ketone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0042181 ! ketone biosynthetic process [Term] id: GO:0010567 name: regulation of ketone catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a ketone, carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0042182 ! ketone catabolic process [Term] id: GO:0010568 name: regulation of budding cell apical bud growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of growth at the tip of a bud, in a cell that reproduces by budding." [GOC:dph, GOC:jp, GOC:tb, PMID:17417630] is_a: GO:0007116 ! regulation of cell budding is_a: GO:0040008 ! regulation of growth is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007118 ! budding cell apical bud growth [Term] id: GO:0010569 name: regulation of double-strand break repair via homologous recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:2000779 ! regulation of double-strand break repair relationship: regulates GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0010570 name: regulation of filamentous growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0040008 ! regulation of growth relationship: regulates GO:0030447 ! filamentous growth [Term] id: GO:0010571 name: positive regulation of nuclear cell cycle DNA replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of The DNA-dependent DNA replication that occurs in the nucleus of eukaryotic organisms as part of the cell cycle." [GOC:mtg_cell_cycle] synonym: "positive regulation of DNA replication during S phase" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of DNA replication involved in S phase" EXACT [] synonym: "positive regulation of DNA replication involved in S-phase" EXACT [] is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0033260 ! nuclear DNA replication [Term] id: GO:0010572 name: positive regulation of platelet activation namespace: biological_process def: "Any process that increases the rate or frequency of platelet activation. Platelet activation is a series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010543 ! regulation of platelet activation is_a: GO:0030194 ! positive regulation of blood coagulation is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0030168 ! platelet activation [Term] id: GO:0010573 name: vascular endothelial growth factor production namespace: biological_process def: "The appearance of vascular endothelial growth factor production due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:rl] synonym: "VEGF production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0010574 name: regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:rl] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010575 name: positive regulation of vascular endothelial growth factor production namespace: biological_process def: "Any process that increases or activates the frequency, rate, or extent of production of vascular endothelial growth factor." [GOC:BHF, GOC:rl] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0010574 ! regulation of vascular endothelial growth factor production relationship: positively_regulates GO:0010573 ! vascular endothelial growth factor production [Term] id: GO:0010578 name: regulation of adenylate cyclase activity involved in G protein-coupled receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of adenylate cyclase (AC) activity that is an integral part of a G protein-coupled receptor signaling pathway." [GOC:dph, GOC:signaling, GOC:tb] synonym: "regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway" EXACT [] synonym: "regulation of adenylate cyclase activity involved in G-protein signaling pathway" EXACT [GOC:signaling] synonym: "regulation of adenylate cyclase activity involved in G-protein signalling" EXACT [GOC:mah] is_a: GO:0045761 ! regulation of adenylate cyclase activity relationship: part_of GO:0007188 ! adenylate cyclase-modulating G protein-coupled receptor signaling pathway [Term] id: GO:0010581 name: regulation of starch biosynthetic process namespace: biological_process def: "An process which modulate the frequency, rate or extent of starch biosynthesis, the chemical reactions and pathways resulting in the formation of starch." [GOC:tb] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:2000904 ! regulation of starch metabolic process relationship: regulates GO:0019252 ! starch biosynthetic process [Term] id: GO:0010582 name: floral meristem determinacy namespace: biological_process def: "The process in which a floral meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [PMID:18441215] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010022 ! meristem determinacy relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010583 name: response to cyclopentenone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cyclopentenone stimulus. Cyclopentenones are oxylipins derived from polyunsaturated fatty acids. They are structurally similar to jasmonic acid, but contain a reactive unsaturated carbonyl structure in the cyclo-ring. Cyclopentenones include phytoprostanes and 12-oxo-phytodienoic acid." [PMID:18334669] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0010584 name: pollen exine formation namespace: biological_process def: "The formation of the pollen exine. The reticulate pollen wall pattern consists of two layers, exine and intine." [GOC:dhl] is_a: GO:0010208 ! pollen wall assembly [Term] id: GO:0010585 name: glutamine secretion namespace: biological_process def: "The controlled release of glutamine by a cell." [PMID:15208395] is_a: GO:0006868 ! glutamine transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0010586 name: miRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] synonym: "microRNA metabolic process" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0010587 name: miRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of miRNA, microRNA, a class of single-stranded RNA molecules of about 21-23 nucleotides in length, which regulates gene expression." [PMID:17993620] synonym: "microRNA catabolic process" EXACT [] is_a: GO:0010586 ! miRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0010588 name: cotyledon vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the cotyledon of vascular plants." [PMID:10559439] is_a: GO:0010051 ! xylem and phloem pattern formation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0048826 ! cotyledon morphogenesis [Term] id: GO:0010589 name: leaf proximal/distal pattern formation namespace: biological_process def: "The regionalization process within a leaf by which specific areas of cell differentiation are determined along a proximal/distal axis." [PMID:18398054] is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0010590 name: regulation of septum digestion after cytokinesis namespace: biological_process alt_id: GO:1902467 alt_id: GO:2001041 def: "Any process that modulates the rate, frequency or extent of the process of physically separating the septal cell wall material by enzymatic digestion, that occurs after daughter cells are separated by cytokinesis." [GOC:mtg_cell_cycle, GOC:TermGenie, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "regulation of cell separation after cytokinesis" RELATED [] synonym: "regulation of cell separation following cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "regulation of mitotic cytokinetic cell separation" EXACT [] is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0010591 name: regulation of lamellipodium assembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1902743 ! regulation of lamellipodium organization relationship: regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010592 name: positive regulation of lamellipodium assembly namespace: biological_process def: "Any process that increases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "positive regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly is_a: GO:1902745 ! positive regulation of lamellipodium organization relationship: positively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010593 name: negative regulation of lamellipodium assembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:dph, GOC:tb] synonym: "negative regulation of lamellipodium biogenesis" RELATED [GOC:mah] is_a: GO:0010591 ! regulation of lamellipodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly is_a: GO:1902744 ! negative regulation of lamellipodium organization relationship: negatively_regulates GO:0030032 ! lamellipodium assembly [Term] id: GO:0010594 name: regulation of endothelial cell migration namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration relationship: regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010595 name: positive regulation of endothelial cell migration namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0010634 ! positive regulation of epithelial cell migration relationship: positively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010596 name: negative regulation of endothelial cell migration namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the orderly movement of an endothelial cell into the extracellular matrix to form an endothelium." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010594 ! regulation of endothelial cell migration is_a: GO:0010633 ! negative regulation of epithelial cell migration relationship: negatively_regulates GO:0043542 ! endothelial cell migration [Term] id: GO:0010597 name: green leaf volatile biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of volatile molecules emitted from green plants, such as hexenal, hexenol and hexenyl acetate, from linoleic acid or linolenic acid." [PMID:17163881] is_a: GO:0019372 ! lipoxygenase pathway [Term] id: GO:0010598 name: NAD(P)H dehydrogenase complex (plastoquinone) namespace: cellular_component def: "Complex that possesses NAD(P)H dehydrogenase (plastoquinone) activity. The complex is one of the components of the electron transport chain. It is involved in electron transport from an unidentified electron donor, possibly NADH, NADPH or ferredoxin(Fd) to the plastoquinone pool." [PMID:15608332] is_a: GO:0044424 ! intracellular part is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0010599 name: production of lsiRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form lsiRNA (long small interfering RNA), a class of siRNAs 30 to 40 nt in length. lsiRNAs are induced by pathogen infection or under specific growth conditions." [PMID:18003861] synonym: "RNA interference, production of lsiRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0010600 name: regulation of auxin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0090354 ! regulation of auxin metabolic process relationship: regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010601 name: positive regulation of auxin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [PMID:18287041] is_a: GO:0010600 ! regulation of auxin biosynthetic process is_a: GO:0046886 ! positive regulation of hormone biosynthetic process is_a: GO:0090355 ! positive regulation of auxin metabolic process relationship: positively_regulates GO:0009851 ! auxin biosynthetic process [Term] id: GO:0010602 name: regulation of 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "Regulation of the chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [PMID:18055613] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process relationship: regulates GO:0018871 ! 1-aminocyclopropane-1-carboxylate metabolic process [Term] id: GO:0010603 name: regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:1902115 ! regulation of organelle assembly relationship: regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010604 name: positive regulation of macromolecule metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: positively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010605 name: negative regulation of macromolecule metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving macromolecules, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: negatively_regulates GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010606 name: positive regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:1902117 ! positive regulation of organelle assembly relationship: positively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010607 name: negative regulation of cytoplasmic mRNA processing body assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the aggregation, arrangement and bonding together of proteins and RNA molecules to form a cytoplasmic mRNA processing body." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0010603 ! regulation of cytoplasmic mRNA processing body assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:1902116 ! negative regulation of organelle assembly relationship: negatively_regulates GO:0033962 ! cytoplasmic mRNA processing body assembly [Term] id: GO:0010608 name: posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of an RNA transcript." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression [Term] id: GO:0010609 name: mRNA localization resulting in posttranscriptional regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression after the production of a mRNA transcript by its transport into, or maintainance in, a specific location within the cell." [GOC:dph, GOC:tb] synonym: "mRNA localisation resulting in posttranscriptional regulation of gene expression" EXACT [] synonym: "posttranscriptional regulation of gene expression by mRNA localisation" EXACT [GOC:mah] synonym: "posttranscriptional regulation of gene expression by mRNA localization" EXACT [] is_a: GO:0008298 ! intracellular mRNA localization is_a: GO:0010608 ! posttranscriptional regulation of gene expression [Term] id: GO:0010610 name: regulation of mRNA stability involved in response to stress namespace: biological_process def: "Any process that modulates the propensity of mRNA molecules to degradation that is part of a change in state or activity of a cell as a result of an exogenous disturbance." [GOC:dph, GOC:tb] is_a: GO:0043488 ! regulation of mRNA stability relationship: part_of GO:0033554 ! cellular response to stress [Term] id: GO:0010611 name: regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:dph, GOC:tb] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010612 name: regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:dph, GOC:tb] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010613 name: positive regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that increases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014742 ! positive regulation of muscle hypertrophy relationship: positively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010614 name: negative regulation of cardiac muscle hypertrophy namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the enlargement or overgrowth of all or part of the heart due to an increase in size (not length) of individual cardiac muscle fibers, without cell division." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010611 ! regulation of cardiac muscle hypertrophy is_a: GO:0014741 ! negative regulation of muscle hypertrophy relationship: negatively_regulates GO:0003300 ! cardiac muscle hypertrophy [Term] id: GO:0010615 name: positive regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that increases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010616 name: negative regulation of cardiac muscle adaptation namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010612 ! regulation of cardiac muscle adaptation is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0010617 name: circadian regulation of calcium ion oscillation namespace: biological_process def: "Any process that modulates the concentration of cytosolic free calcium ion [Ca2+]cyt with a regularity of approximately 24 hours." [PMID:17982000] synonym: "circadian regulation of [Ca2+]cyt oscillation" RELATED [] synonym: "circadian regulation of Ca2+ oscillation" RELATED [] synonym: "circadian regulation of cytosolic calcium ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "circadian regulation of cytosolic free calcium ion oscillation" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0051480 ! regulation of cytosolic calcium ion concentration [Term] id: GO:0010618 name: aerenchyma formation namespace: biological_process def: "The process that gives rise to aerenchyma, parenchyma tissue containing particularly large intercellular spaces of schizogenous or lysigenous origin. This process pertains to the initial formation of a structure from unspecified parts." [PMID:18055613, PO:0005702] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0010619 name: adenylate cyclase-activating glucose-activated G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glucose binding to a G protein-coupled receptor, where the pathway proceeds with activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:signaling, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose involved in G-protein signaling" RELATED [GOC:dph, GOC:tb] synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signaling pathway" RELATED [GOC:signaling] synonym: "activation of adenylate cyclase activity by glucose-triggered G-protein signalling pathway" RELATED [GOC:mah] synonym: "adenylate cyclase-activating glucose-activated G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007189 ! adenylate cyclase-activating G protein-coupled receptor signaling pathway relationship: part_of GO:0010255 ! glucose mediated signaling pathway [Term] id: GO:0010620 name: negative regulation of transcription by transcription factor catabolism namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the catabolism of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:bf, GOC:dph, GOC:tb] is_a: GO:0036369 ! transcription factor catabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010621 name: negative regulation of transcription by transcription factor localization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves the localization of a transcription factor." [GOC:dph, GOC:tb] synonym: "negative regulation of transcription by transcription factor localisation" EXACT [GOC:mah] is_a: GO:0034613 ! cellular protein localization is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010622 name: specification of ovule identity namespace: biological_process def: "The regionalization process in which the identity of an ovule is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0048482 ! plant ovule morphogenesis [Term] id: GO:0010623 name: programmed cell death involved in cell development namespace: biological_process def: "The activation of endogenous cellular processes that result in the death of a cell as part of its development." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] comment: This process is part of the natural developmental program of some cell types, but it does not always happen as part of the development or shaping of a gross anatomical structure. synonym: "developmental programmed cell death" BROAD [] synonym: "programmed cell death involved in development" BROAD [] is_a: GO:0012501 ! programmed cell death is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0048468 ! cell development [Term] id: GO:0010624 name: regulation of Schwann cell proliferation namespace: biological_process def: "Any process that modulates the frequency or rate of multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0060251 ! regulation of glial cell proliferation relationship: regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010625 name: positive regulation of Schwann cell proliferation namespace: biological_process def: "Any process that increases the frequency or rate of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060252 ! positive regulation of glial cell proliferation relationship: positively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010626 name: negative regulation of Schwann cell proliferation namespace: biological_process def: "Any process that decreases the frequency or extent of the multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:dph, GOC:sl, GOC:tb] is_a: GO:0010624 ! regulation of Schwann cell proliferation is_a: GO:0060253 ! negative regulation of glial cell proliferation relationship: negatively_regulates GO:0014010 ! Schwann cell proliferation [Term] id: GO:0010628 name: positive regulation of gene expression namespace: biological_process def: "Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010604 ! positive regulation of macromolecule metabolic process relationship: positively_regulates GO:0010467 ! gene expression [Term] id: GO:0010629 name: negative regulation of gene expression namespace: biological_process def: "Any process that decreases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA or circRNA (for protein-coding genes) and the translation of that mRNA or circRNA into protein. Protein maturation is included when required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] comment: This term covers any process that negatively regulates the rate of production of a mature gene product, and so includes processes that negatively regulate that rate by reducing the level, stability or availability of intermediates in the process of gene expression. For example, it covers any process that reduces the level, stability or availability of mRNA or circRNA for translation and thereby reduces the rate of production of the encoded protein via translation. is_a: GO:0010468 ! regulation of gene expression is_a: GO:0010605 ! negative regulation of macromolecule metabolic process relationship: negatively_regulates GO:0010467 ! gene expression [Term] id: GO:0010630 name: regulation of transcription, start site selection namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the synthesis of either RNA on a template of DNA or DNA on a template of RNA by a mechanism that selects the start site along that template." [GOC:dph, GOC:tb] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process [Term] id: GO:0010631 name: epithelial cell migration namespace: biological_process def: "The orderly movement of an epithelial cell from one site to another, often during the development of a multicellular organism." [GOC:ascb_2009, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0090132 ! epithelium migration [Term] id: GO:0010632 name: regulation of epithelial cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0030334 ! regulation of cell migration is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010633 name: negative regulation of epithelial cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030336 ! negative regulation of cell migration is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010634 name: positive regulation of epithelial cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell migration." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010632 ! regulation of epithelial cell migration is_a: GO:0030335 ! positive regulation of cell migration is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0010631 ! epithelial cell migration [Term] id: GO:0010635 name: regulation of mitochondrial fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010821 ! regulation of mitochondrion organization is_a: GO:0022603 ! regulation of anatomical structure morphogenesis relationship: regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010636 name: positive regulation of mitochondrial fusion namespace: biological_process def: "Any process that increases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010822 ! positive regulation of mitochondrion organization is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010637 name: negative regulation of mitochondrial fusion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of merging of two or more mitochondria within a cell to form a single compartment." [GOC:dph, GOC:tb] is_a: GO:0010635 ! regulation of mitochondrial fusion is_a: GO:0010823 ! negative regulation of mitochondrion organization is_a: GO:0051093 ! negative regulation of developmental process relationship: negatively_regulates GO:0008053 ! mitochondrial fusion [Term] id: GO:0010638 name: positive regulation of organelle organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "positive regulation of organelle organisation" EXACT [GOC:mah] synonym: "positive regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010639 name: negative regulation of organelle organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:dph, GOC:tb] synonym: "negative regulation of organelle organisation" EXACT [GOC:mah] synonym: "negative regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0006996 ! organelle organization [Term] id: GO:0010640 name: regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010641 name: positive regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: positively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010642 name: negative regulation of platelet-derived growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the platelet-derived growth factor receptor signaling pathway." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of platelet-derived growth factor receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010640 ! regulation of platelet-derived growth factor receptor signaling pathway relationship: negatively_regulates GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0010643 name: cell communication by chemical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010644 name: cell communication by electrical coupling namespace: biological_process def: "The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0007154 ! cell communication [Term] id: GO:0010645 name: regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010646 name: regulation of cell communication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007154 ! cell communication [Term] id: GO:0010647 name: positive regulation of cell communication namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0007154 ! cell communication [Term] id: GO:0010648 name: negative regulation of cell communication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication. Cell communication is the process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0007154 ! cell communication [Term] id: GO:0010649 name: regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010650 name: positive regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling relationship: positively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010651 name: negative regulation of cell communication by electrical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via electrical coupling. Cell communication via electrical coupling is the process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0010649 ! regulation of cell communication by electrical coupling relationship: negatively_regulates GO:0010644 ! cell communication by electrical coupling [Term] id: GO:0010652 name: positive regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010647 ! positive regulation of cell communication relationship: positively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010653 name: negative regulation of cell communication by chemical coupling namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell communication via chemical coupling. Cell communication by chemical coupling is the process that mediates signaling interactions between one cell and another cell by the transfer of small, water-soluble molecules or metabolites between their adjacent cytoplasms via intercellular protein channels." [GOC:dph, GOC:kmv, GOC:tb] is_a: GO:0010645 ! regulation of cell communication by chemical coupling is_a: GO:0010648 ! negative regulation of cell communication relationship: negatively_regulates GO:0010643 ! cell communication by chemical coupling [Term] id: GO:0010654 name: apical cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an apical cell. The apical cell is the upper cell formed after the first division of the zygote." [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010656 name: negative regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "negative regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process relationship: negatively_regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010657 name: muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a muscle cell and result in its death. A muscle cell is a mature contractile cell, commonly known as a myocyte, that forms one of three kinds of muscle." [CL:0000187, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "muscle cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0010658 name: striated muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a striated muscle cell and result in its death. Striated muscle cells make up striated muscle fibers which are divided by transverse bands into striations." [CL:0000737, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "striated muscle cell apoptosis" NARROW [] is_a: GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010659 name: cardiac muscle cell apoptotic process namespace: biological_process def: "A form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases, whose actions dismantle a cardiac muscle cell and result in its death. Cardiac muscle cells are striated muscle cells that are responsible for heart contraction." [CL:0000746, GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010660 name: regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of muscle cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process relationship: regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010661 name: positive regulation of muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or frequency of muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process relationship: positively_regulates GO:0010657 ! muscle cell apoptotic process [Term] id: GO:0010662 name: regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010660 ! regulation of muscle cell apoptotic process relationship: regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010663 name: positive regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010661 ! positive regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process relationship: positively_regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010664 name: negative regulation of striated muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of striated muscle cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a striated muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of striated muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of striated muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of striated muscle cell apoptosis" NARROW [] is_a: GO:0010656 ! negative regulation of muscle cell apoptotic process is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process relationship: negatively_regulates GO:0010658 ! striated muscle cell apoptotic process [Term] id: GO:0010665 name: regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that modulates the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010662 ! regulation of striated muscle cell apoptotic process relationship: regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010666 name: positive regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that increases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:dph, GOC:mtg_apoptosis, GOC:tb] synonym: "positive regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010663 ! positive regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process relationship: positively_regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010667 name: negative regulation of cardiac muscle cell apoptotic process namespace: biological_process def: "Any process that decreases the rate or extent of cardiac cell apoptotic process, a form of programmed cell death induced by external or internal signals that trigger the activity of proteolytic caspases whose actions dismantle a cardiac muscle cell and result in its death." [GOC:BHF, GOC:dph, GOC:mtg_apoptosis, GOC:rl, GOC:tb] synonym: "down regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of cardiac muscle cell apoptosis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of cardiac muscle cell apoptosis" NARROW [GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of cardiac muscle cell apoptosis" NARROW [] is_a: GO:0010664 ! negative regulation of striated muscle cell apoptotic process is_a: GO:0010665 ! regulation of cardiac muscle cell apoptotic process relationship: negatively_regulates GO:0010659 ! cardiac muscle cell apoptotic process [Term] id: GO:0010668 name: ectodermal cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an ectodermal cell. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GOC:dph, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0010669 name: epithelial structure maintenance namespace: biological_process def: "A tissue homeostatic process required for the maintenance of epithelial structure." [GOC:dph, GOC:tb] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0010670 name: obsolete positive regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "positive regulation of oxygen and reactive oxygen species metabolic process" EXACT [] is_obsolete: true consider: GO:2000376 consider: GO:2000379 [Term] id: GO:0010671 name: obsolete negative regulation of oxygen and reactive oxygen species metabolic process namespace: biological_process def: "OBSOLETE. Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:BHF, GOC:dph, GOC:tb] comment: This term was made obsolete because, as part of the GO/ChEBI alignment effort, curators determined that oxygen and reactive oxygen species should not be grouped together. synonym: "negative regulation of oxygen and reactive oxygen species metabolic process" EXACT [] is_obsolete: true consider: GO:2000375 consider: GO:2000378 [Term] id: GO:0010672 name: regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900401 def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:12161753] synonym: "regulation of meiosis by regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0051037 ! regulation of transcription involved in meiotic cell cycle [Term] id: GO:0010673 name: positive regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900476 def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "positive regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "positive regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "stimulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by positive regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0051039 ! positive regulation of transcription involved in meiotic cell cycle [Term] id: GO:0010674 name: negative regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle namespace: biological_process alt_id: GO:1900475 def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as part of the meiotic cell cycle." [GOC:dph, GOC:tb, PMID:8618927] synonym: "activation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "negative regulation of transcription from RNA polymerase II promoter, meiotic" EXACT [GOC:mah] synonym: "positive regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [] synonym: "stimulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "up-regulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] synonym: "upregulation of meiosis by negative regulation of transcription from RNA polymerase II promoter" NARROW [GOC:TermGenie] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010672 ! regulation of transcription from RNA polymerase II promoter involved in meiotic cell cycle is_a: GO:0051038 ! negative regulation of transcription involved in meiotic cell cycle [Term] id: GO:0010675 name: regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010676 name: positive regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that increases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045913 ! positive regulation of carbohydrate metabolic process relationship: positively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010677 name: negative regulation of cellular carbohydrate metabolic process namespace: biological_process def: "Any process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y, as carried out by individual cells." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0045912 ! negative regulation of carbohydrate metabolic process relationship: negatively_regulates GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0010678 name: negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-templated namespace: biological_process def: "Any cellular process that decreases the rate, extent or frequency of the chemical reactions and pathways involving carbohydrates carried out by repression of transcription." [GOC:dph, GOC:tb] synonym: "negative regulation of cellular carbohydrate metabolic process by negative regulation of transcription, DNA-dependent" EXACT [GOC:txnOH] synonym: "negative regulation of cellular carbohydrate metabolic process by repression of transcription" EXACT [GOC:bf, GOC:vw] synonym: "negative regulation of cellular carbohydrate metabolic process by transcriptional repression" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010679 name: cinnamic acid biosynthetic process involved in salicylic acid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of salicylic acid." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010680 name: cinnamic acid biosynthetic process involved in coumarin metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of coumarin." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009804 ! coumarin metabolic process [Term] id: GO:0010681 name: cinnamic acid biosynthetic process involved in stilbene metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of stilbene." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009810 ! stilbene metabolic process [Term] id: GO:0010682 name: cinnamic acid biosynthetic process involved in flavonoid metabolism namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid, which is then utilized in the metabolism of flavonoids." [GOC:dph, GOC:tb] is_a: GO:0009800 ! cinnamic acid biosynthetic process relationship: part_of GO:0009812 ! flavonoid metabolic process [Term] id: GO:0010683 name: tricyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0010684 name: tricyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tricyclic triterpenoid compounds, terpenoids with six isoprene units and 3 rings." [GOC:tair_curators] synonym: "tricyclic triterpenoid catabolism" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0010685 name: tetracyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid metabolism" EXACT [GOC:tair_curators] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0010686 name: tetracyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetracyclic triterpenoid compounds, terpenoids with six isoprene units and 4 carbon rings." [GOC:tair_curators] synonym: "tetracyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] is_a: GO:0010685 ! tetracyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0010688 name: negative regulation of ribosomal protein gene transcription by RNA polymerase II namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes mediated by RNA polymerase II." [GOC:dph, GOC:tb, GOC:txnOH] synonym: "negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter" EXACT [] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0060962 ! regulation of ribosomal protein gene transcription by RNA polymerase II [Term] id: GO:0010689 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to chemical stimulus namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a chemical stimulus." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II relationship: part_of GO:0042221 ! response to chemical [Term] id: GO:0010690 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to stress namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a disturbance in organismal or cellular homeostasis." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0010691 name: negative regulation of ribosomal protein gene transcription from RNA polymerase II promoter in response to nutrient levels namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the synthesis of RNA from ribosomal protein genes by RNA polymerase II, originating at an RNA polymerase II promoter, as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:dph, GOC:tb, GOC:txnOH] is_a: GO:0010688 ! negative regulation of ribosomal protein gene transcription by RNA polymerase II is_a: GO:0031669 ! cellular response to nutrient levels [Term] id: GO:0010692 name: regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0010693 name: negative regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010923 ! negative regulation of phosphatase activity [Term] id: GO:0010694 name: positive regulation of alkaline phosphatase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of alkaline phosphatase activity, the catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [GOC:dph, GOC:tb] is_a: GO:0010692 ! regulation of alkaline phosphatase activity is_a: GO:0010922 ! positive regulation of phosphatase activity [Term] id: GO:0010695 name: regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0000073 ! mitotic spindle pole body separation [Term] id: GO:0010696 name: positive regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that increases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "positive regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of mitotic spindle pole body separation is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000073 ! mitotic spindle pole body separation [Term] id: GO:0010697 name: negative regulation of mitotic spindle pole body separation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the process involving the release of duplicated mitotic spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane." [GOC:dph, GOC:tb, PMID:16792804, PMID:18500339] synonym: "negative regulation of SPB separation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010695 ! regulation of mitotic spindle pole body separation is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0000073 ! mitotic spindle pole body separation [Term] id: GO:0010698 name: acetyltransferase activator activity namespace: molecular_function def: "Binds to and increases the activity of an acetyltransferase, an enzyme which catalyzes the transfer of an acetyl group to an acceptor molecule." [GOC:dph, GOC:jp, GOC:tb, PMID:18690240] synonym: "acetyltransferase stimulator activity" EXACT [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0010699 name: cell-cell signaling involved in quorum sensing namespace: biological_process def: "The cell-cell signaling process in which single-celled organisms monitor population density by detecting the concentration of small diffusible signal molecules." [GOC:dph, GOC:tb] synonym: "cell-cell signalling involved in quorum sensing" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0009372 ! quorum sensing [Term] id: GO:0010700 name: negative regulation of norepinephrine secretion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion relationship: negatively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010701 name: positive regulation of norepinephrine secretion namespace: biological_process def: "Any process that increases the frequency, rate or extent of the regulated release of norepinephrine." [GOC:dph, GOC:tb] is_a: GO:0014061 ! regulation of norepinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion relationship: positively_regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0010702 name: obsolete regulation of histolysis namespace: biological_process def: "OBSOLETE. Any process that modulates the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0010703 name: obsolete negative regulation of histolysis namespace: biological_process def: "OBSOLETE. Any process that decreases the rate, frequency or extent of the breakdown of tissues; usually, if not always, accompanied by cell death." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. synonym: "down regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "down-regulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "downregulation of histolysis" EXACT [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of histolysis" NARROW [GOC:dph, GOC:rl, GOC:tb] is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0010704 name: meiotic DNA double-strand break processing involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang resulting in the transfer of genetic information from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010705 name: meiotic DNA double-strand break processing involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs resulting in double strand break formation and repair through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000706 ! meiotic DNA double-strand break processing relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010706 name: ganglioside biosynthetic process via lactosylceramide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gangliosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] synonym: "biosynthesis of lactosylceramide precursor to ganglioside" RELATED [GOC:bf, GOC:dph, GOC:tb] synonym: "ganglioside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] synonym: "lactosylceramide biosynthesis leading to ganglioside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to ganglioside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001574 ! ganglioside biosynthetic process [Term] id: GO:0010707 name: globoside biosynthetic process via lactosylceramide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of globosides that begins with the formation of lactosylceramides, Gal-beta-(1->4)-Glc-beta-(1->1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group." [GOC:bf, GOC:dph, GOC:tb] synonym: "biosynthesis of lactosylceramide precursor to globoside" RELATED [GOC:bf, GOC:dph, GOC:tb] synonym: "globoside biosynthesis via lactosylceramide biosynthesis" EXACT [GOC:bf] synonym: "lactosylceramide biosynthesis leading to globoside" RELATED [GOC:dph, GOC:tb] synonym: "lactosylceramide biosynthetic process leading to globoside" RELATED [GOC:dph, GOC:tb] is_a: GO:0001576 ! globoside biosynthetic process [Term] id: GO:0010708 name: heteroduplex formation involved in gene conversion at mating-type locus namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the conversion of the mating-type locus from one allele to another." [GOC:dph, GOC:tb] is_a: GO:0022414 ! reproductive process is_a: GO:0030491 ! heteroduplex formation relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0010709 name: heteroduplex formation involved in double-strand break repair via synthesis-dependent strand annealing namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules resulting in the error-free repair of a double-strand break without the exchange of adjacent sequences." [GOC:dph, GOC:tb] is_a: GO:0030491 ! heteroduplex formation relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010710 name: regulation of collagen catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0010712 ! regulation of collagen metabolic process relationship: regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010711 name: negative regulation of collagen catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of collagen catabolism. Collagen catabolism is the proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of collagen catabolic process" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of collagen catabolic process" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of collagen breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen catabolism" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of collagen degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0010710 ! regulation of collagen catabolic process is_a: GO:0010713 ! negative regulation of collagen metabolic process relationship: negatively_regulates GO:0030574 ! collagen catabolic process [Term] id: GO:0010712 name: regulation of collagen metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010713 name: negative regulation of collagen metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process relationship: negatively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010714 name: positive regulation of collagen metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the metabolism of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:dph, GOC:tb] synonym: "positive regulation of collagen metabolism" EXACT [GOC:dph, GOC:tb] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0010712 ! regulation of collagen metabolic process relationship: positively_regulates GO:0032963 ! collagen metabolic process [Term] id: GO:0010715 name: regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that modulates the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:1903053 ! regulation of extracellular matrix organization relationship: regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010716 name: negative regulation of extracellular matrix disassembly namespace: biological_process def: "Any process that decreases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix." [GOC:BHF, GOC:dph, GOC:tb] synonym: "down regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "down-regulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "downregulation of extracellular matrix disassembly" EXACT [GOC:dph, GOC:tb] synonym: "inhibition of extracellular matrix disassembly" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix breakdown" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of extracellular matrix degradation" EXACT [GOC:dph, GOC:tb] is_a: GO:0010715 ! regulation of extracellular matrix disassembly is_a: GO:1903054 ! negative regulation of extracellular matrix organization relationship: negatively_regulates GO:0022617 ! extracellular matrix disassembly [Term] id: GO:0010717 name: regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010718 name: positive regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that increases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition is where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010719 name: negative regulation of epithelial to mesenchymal transition namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of epithelial to mesenchymal transition. Epithelial to mesenchymal transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010717 ! regulation of epithelial to mesenchymal transition is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001837 ! epithelial to mesenchymal transition [Term] id: GO:0010720 name: positive regulation of cell development namespace: biological_process def: "Any process that increases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: positively_regulates GO:0048468 ! cell development [Term] id: GO:0010721 name: negative regulation of cell development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the progression of the cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0060284 ! regulation of cell development relationship: negatively_regulates GO:0048468 ! cell development [Term] id: GO:0010722 name: regulation of ferrochelatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ferrochelatase activity; catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [GOC:dph, GOC:tb] is_a: GO:0051339 ! regulation of lyase activity [Term] id: GO:0010723 name: positive regulation of transcription from RNA polymerase II promoter in response to iron namespace: biological_process def: "Any process that increases the rate of transcription from an RNA polymerase II promoter in response to an iron stimulus." [GOC:dph, GOC:tb] is_a: GO:0034395 ! regulation of transcription from RNA polymerase II promoter in response to iron is_a: GO:1901522 ! positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus [Term] id: GO:0010724 name: regulation of definitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of definitive erythrocyte differentiation. Definitive erythrocyte differentiation occurs as part of the process of definitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive erythropoiesis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of definitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of definitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation relationship: regulates GO:0060318 ! definitive erythrocyte differentiation [Term] id: GO:0010725 name: regulation of primitive erythrocyte differentiation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of primitive erythrocyte differentiation. Primitive erythrocyte differentiation occurs as part of the process of primitive hemopoiesis." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive erythropoeisis" EXACT [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of primitive RBC differentiation" EXACT [CL:0000232] synonym: "regulation of primitive red blood cell differentiation" EXACT [CL:0000232] is_a: GO:0045646 ! regulation of erythrocyte differentiation is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0060319 ! primitive erythrocyte differentiation [Term] id: GO:0010726 name: positive regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0051194 ! positive regulation of cofactor metabolic process is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process relationship: positively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010727 name: negative regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide metabolism" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0051195 ! negative regulation of cofactor metabolic process is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process relationship: negatively_regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010728 name: regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010310 ! regulation of hydrogen peroxide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1903426 ! regulation of reactive oxygen species biosynthetic process relationship: regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010729 name: positive regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "positive regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010726 ! positive regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1903428 ! positive regulation of reactive oxygen species biosynthetic process relationship: positively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010730 name: negative regulation of hydrogen peroxide biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of hydrogen peroxide biosynthesis. The chemical reactions and pathways resulting in the formation of hydrogen peroxide (H2O2), a potentially harmful byproduct of aerobic cellular respiration which can cause damage to DNA." [GOC:dph, GOC:hjd, GOC:tb] synonym: "negative regulation of hydrogen peroxide biosynthesis" EXACT [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0010727 ! negative regulation of hydrogen peroxide metabolic process is_a: GO:0010728 ! regulation of hydrogen peroxide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:1903427 ! negative regulation of reactive oxygen species biosynthetic process relationship: negatively_regulates GO:0050665 ! hydrogen peroxide biosynthetic process [Term] id: GO:0010731 name: protein glutathionylation namespace: biological_process def: "The protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0010732 name: regulation of protein glutathionylation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010733 name: positive regulation of protein glutathionylation namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "positive regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031401 ! positive regulation of protein modification process relationship: positively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010734 name: negative regulation of protein glutathionylation namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of protein glutathionylation. Protein glutathionylation is the protein modification process in which a glutathione molecule is added to a protein amino acid through a disulfide linkage." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] synonym: "negative regulation of protein amino acid glutathionylation" EXACT [GOC:bf] is_a: GO:0010732 ! regulation of protein glutathionylation is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0010731 ! protein glutathionylation [Term] id: GO:0010735 name: positive regulation of transcription via serum response element binding namespace: biological_process def: "Any process that increases the frequency, rate or extent of the specifically regulated synthesis of RNA from DNA encoding a specific set of genes as a result of a transcription factor interacting with a serum response element (SRE). A serum response element is a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II [Term] id: GO:0010736 name: serum response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the serum response element (SRE), a short sequence with dyad symmetry found in the promoters of some of the cellular immediate-early genes, regulated by serum." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. is_a: GO:0000978 ! RNA polymerase II proximal promoter sequence-specific DNA binding [Term] id: GO:0010737 name: protein kinase A signaling namespace: biological_process def: "A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "protein kinase A signal transduction" EXACT [GOC:signaling] synonym: "protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0010738 name: regulation of protein kinase A signaling namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "regulation of protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction relationship: regulates GO:0010737 ! protein kinase A signaling [Term] id: GO:0010739 name: positive regulation of protein kinase A signaling namespace: biological_process def: "Any process that increases the rate, frequency, or extent of protein kinase A signaling. PKA signaling is the series of reactions, mediated by the intracellular serine/threonine kinase protein kinase A, which occurs as a result of a single trigger reaction or compound." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of PKA signaling cascade" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of protein kinase A signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of protein kinase A signalling cascade" RELATED [GOC:mah] is_a: GO:0010738 ! regulation of protein kinase A signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction relationship: positively_regulates GO:0010737 ! protein kinase A signaling [Term] id: GO:0010742 name: macrophage derived foam cell differentiation namespace: biological_process def: "The process in which a monocyte acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0090077 ! foam cell differentiation [Term] id: GO:0010743 name: regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010744 name: positive regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010745 name: negative regulation of macrophage derived foam cell differentiation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage derived foam cell differentiation. Macrophage derived foam cell differentiation is the process in which a macrophage acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions." [GOC:add, GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010743 ! regulation of macrophage derived foam cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0010742 ! macrophage derived foam cell differentiation [Term] id: GO:0010746 name: regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0140212 ! regulation of long-chain fatty acid import into cell is_a: GO:1903959 ! regulation of anion transmembrane transport relationship: regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010747 name: positive regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane is_a: GO:0140214 ! positive regulation of long-chain fatty acid import into cell is_a: GO:1903961 ! positive regulation of anion transmembrane transport relationship: positively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010748 name: negative regulation of long-chain fatty acid import across plasma membrane namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasma membrane long-chain fatty acid transport. Plasma membrane long-chain fatty acid transport is the directed movement of long-chain fatty acids across the plasma membrane." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0010746 ! regulation of long-chain fatty acid import across plasma membrane is_a: GO:0140213 ! negative regulation of long-chain fatty acid import into cell is_a: GO:1903960 ! negative regulation of anion transmembrane transport relationship: negatively_regulates GO:0015911 ! long-chain fatty acid import across plasma membrane [Term] id: GO:0010749 name: regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that modulates the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction relationship: regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010750 name: positive regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that increases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:1902533 ! positive regulation of intracellular signal transduction relationship: positively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010751 name: negative regulation of nitric oxide mediated signal transduction namespace: biological_process def: "Any process that decreases the rate, frequency or extent of nitric oxide mediated signal transduction. Nitric oxide mediated signal transduction is a series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of nitric oxide-mediated signal transduction" EXACT [] is_a: GO:0010749 ! regulation of nitric oxide mediated signal transduction is_a: GO:1902532 ! negative regulation of intracellular signal transduction relationship: negatively_regulates GO:0007263 ! nitric oxide mediated signal transduction [Term] id: GO:0010752 name: regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:1902531 ! regulation of intracellular signal transduction relationship: regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010753 name: positive regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that increases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction relationship: positively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010754 name: negative regulation of cGMP-mediated signaling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cGMP-mediated signaling. cGMP-mediated signaling is a series of molecular signals in which a cell uses cyclic GMP to convert an extracellular signal into a response." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cGMP-mediated signalling" EXACT [GOC:mah] is_a: GO:0010752 ! regulation of cGMP-mediated signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction relationship: negatively_regulates GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0010755 name: regulation of plasminogen activation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0070613 ! regulation of protein processing relationship: regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010756 name: positive regulation of plasminogen activation namespace: biological_process def: "Any process that increases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010954 ! positive regulation of protein processing relationship: positively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010757 name: negative regulation of plasminogen activation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of plasminogen activation. Plasminogen activation is the process in which plasminogen is processed to plasmin." [GOC:BHF, GOC:dph, GOC:tb] synonym: "inhibition of plasminogen activation" NARROW [GOC:dph, GOC:tb] is_a: GO:0010755 ! regulation of plasminogen activation is_a: GO:0010955 ! negative regulation of protein processing relationship: negatively_regulates GO:0031639 ! plasminogen activation [Term] id: GO:0010758 name: regulation of macrophage chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:1905521 ! regulation of macrophage migration relationship: regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010759 name: positive regulation of macrophage chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002690 ! positive regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:0071622 ! regulation of granulocyte chemotaxis is_a: GO:0071675 ! regulation of mononuclear cell migration is_a: GO:1905523 ! positive regulation of macrophage migration relationship: positively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010760 name: negative regulation of macrophage chemotaxis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage chemotaxis. Macrophage chemotaxis is the movement of a macrophage in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002689 ! negative regulation of leukocyte chemotaxis is_a: GO:0010758 ! regulation of macrophage chemotaxis is_a: GO:1905522 ! negative regulation of macrophage migration relationship: negatively_regulates GO:0048246 ! macrophage chemotaxis [Term] id: GO:0010761 name: fibroblast migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a fibroblast pseudopodium. A fibroblast is a connective tissue cell which secretes an extracellular matrix rich in collagen and other macromolecules." [GOC:BHF, GOC:dph, GOC:tb] synonym: "fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0001667 ! ameboidal-type cell migration [Term] id: GO:0010762 name: regulation of fibroblast migration namespace: biological_process def: "Any process that modulates the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010763 name: positive regulation of fibroblast migration namespace: biological_process def: "Any process that increases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010764 name: negative regulation of fibroblast migration namespace: biological_process def: "Any process that decreases the rate, frequency or extent of fibroblast cell migration. Fibroblast cell migration is accomplished by extension and retraction of a pseudopodium." [GOC:dph, GOC:tb] synonym: "negative regulation of fibroblast cell migration" EXACT [GOC:dph] is_a: GO:0010762 ! regulation of fibroblast migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0010761 ! fibroblast migration [Term] id: GO:0010765 name: positive regulation of sodium ion transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043270 ! positive regulation of ion transport relationship: positively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010766 name: negative regulation of sodium ion transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0002028 ! regulation of sodium ion transport is_a: GO:0043271 ! negative regulation of ion transport relationship: negatively_regulates GO:0006814 ! sodium ion transport [Term] id: GO:0010767 name: regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0006974 ! cellular response to DNA damage stimulus is_a: GO:0034644 ! cellular response to UV is_a: GO:0043618 ! regulation of transcription from RNA polymerase II promoter in response to stress [Term] id: GO:0010768 name: negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage namespace: biological_process def: "Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a UV damage stimulus." [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription by RNA polymerase II is_a: GO:0010767 ! regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage [Term] id: GO:0010769 name: regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0060284 ! regulation of cell development relationship: regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010770 name: positive regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010720 ! positive regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010771 name: negative regulation of cell morphogenesis involved in differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell morphogenesis contributing to cell differentiation. Cell morphogenesis involved in differentiation is the change in form (cell shape and size) that occurs when relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:dph, GOC:tb] is_a: GO:0010721 ! negative regulation of cell development is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0000904 ! cell morphogenesis involved in differentiation [Term] id: GO:0010772 name: meiotic DNA recombinase assembly involved in reciprocal meiotic recombination namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010773 name: meiotic DNA recombinase assembly involved in meiotic gene conversion namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000707 ! meiotic DNA recombinase assembly relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010774 name: meiotic strand invasion involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010775 name: meiotic strand invasion involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate resulting in meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0000708 ! meiotic strand invasion relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010776 name: meiotic mismatch repair involved in meiotic gene conversion namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010777 name: meiotic mismatch repair involved in reciprocal meiotic recombination namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000710 ! meiotic mismatch repair relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010778 name: meiotic DNA repair synthesis involved in reciprocal meiotic recombination namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010779 name: meiotic DNA repair synthesis involved in meiotic gene conversion namespace: biological_process def: "The synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0000711 ! meiotic DNA repair synthesis relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010780 name: meiotic DNA double-strand break formation involved in reciprocal meiotic recombination namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic recombination. Meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010781 name: meiotic DNA double-strand break formation involved in meiotic gene conversion namespace: biological_process def: "The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I resulting in meiotic gene conversion. Meiotic gene conversion is the cell cycle process in which genetic information is transferred from one helix to another." [GOC:dph, GOC:tb] is_a: GO:0042138 ! meiotic DNA double-strand break formation relationship: part_of GO:0006311 ! meiotic gene conversion [Term] id: GO:0010782 name: proboscis morphogenesis, labial disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the labial disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007454 ! labial disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010783 name: proboscis morphogenesis, eye-antennal disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the eye-antennal disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007455 ! eye-antennal disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010784 name: proboscis morphogenesis, clypeo-labral disc-derived namespace: biological_process def: "The process in which the anatomical structures of the proboscis that are derived from the clypeo-labral disc are generated and organized." [GOC:dph, GOC:tb] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0007453 ! clypeo-labral disc morphogenesis relationship: part_of GO:0048734 ! proboscis morphogenesis [Term] id: GO:0010785 name: clathrin coating of Golgi vesicle, plasma membrane to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the plasma membrane to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048201 ! vesicle targeting, plasma membrane to endosome [Term] id: GO:0010786 name: clathrin coating of Golgi vesicle, trans-Golgi to endosome targeting namespace: biological_process def: "The addition of clathrin and adaptor proteins to Golgi membranes during the formation of transport vesicles that will move from the trans-Golgi to the endosome, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048202 ! clathrin coating of Golgi vesicle relationship: part_of GO:0048203 ! vesicle targeting, trans-Golgi to endosome [Term] id: GO:0010787 name: COPI coating of Golgi vesicle, inter-Golgi cisterna namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of inter-Golgi cisterna transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048204 ! vesicle targeting, inter-Golgi cisterna [Term] id: GO:0010788 name: COPI coating of Golgi vesicle, cis-Golgi to rough ER namespace: biological_process def: "The addition of COPI proteins and adaptor proteins to Golgi membranes during the formation of cis-Golgi to rough ER transport vesicles, forming a vesicle coat." [GOC:dph, GOC:tb] is_a: GO:0048205 ! COPI coating of Golgi vesicle relationship: part_of GO:0048206 ! vesicle targeting, cis-Golgi to rough endoplasmic reticulum [Term] id: GO:0010789 name: meiotic sister chromatid cohesion involved in meiosis I namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis I." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0010790 name: meiotic sister chromatid cohesion involved in meiosis II namespace: biological_process def: "The cell cycle process in which sister chromatids of a replicated chromosome are joined along the entire length of the chromosome during meiosis II." [GOC:dph, GOC:tb] is_a: GO:0051177 ! meiotic sister chromatid cohesion [Term] id: GO:0010791 name: DNA double-strand break processing involved in repair via synthesis-dependent strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via synthesis-dependent strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0010792 name: DNA double-strand break processing involved in repair via single-strand annealing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang that results in the repair of a double strand break via single-strand annealing." [GOC:dph, GOC:tb] is_a: GO:0000729 ! DNA double-strand break processing relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0010793 name: regulation of mRNA export from nucleus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of mRNA from the nucleus to the cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression is_a: GO:0046825 ! regulation of protein export from nucleus is_a: GO:0046831 ! regulation of RNA export from nucleus is_a: GO:2000197 ! regulation of ribonucleoprotein complex localization relationship: regulates GO:0006406 ! mRNA export from nucleus [Term] id: GO:0010794 name: regulation of dolichol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dolichol biosynthesis. Dolichol biosynthesis consists of the chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [GOC:dph, GOC:tb] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process relationship: regulates GO:0019408 ! dolichol biosynthetic process [Term] id: GO:0010795 name: regulation of ubiquinone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ubiquinone biosynthesis. Ubiquinone biosynthesis consists of the chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:dph, GOC:tb] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process relationship: regulates GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0010796 name: regulation of multivesicular body size namespace: biological_process def: "Any process that modulates the volume of a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0051036 ! regulation of endosome size [Term] id: GO:0010797 name: regulation of multivesicular body size involved in endosome transport namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the directed movement of substances from endosomes to lysosomes or vacuoles." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size relationship: part_of GO:0032509 ! endosome transport via multivesicular body sorting pathway [Term] id: GO:0010798 name: regulation of multivesicular body size involved in ubiquitin-dependent protein catabolism namespace: biological_process def: "Any process that modulates the volume of a multivesicular body as part of the chemical reactions and pathways resulting in the breakdown of a protein or peptide covalently tagged with ubiquitin." [GOC:dph, GOC:tb] is_a: GO:0010796 ! regulation of multivesicular body size relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0010799 name: regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010800 name: positive regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation relationship: positively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010801 name: negative regulation of peptidyl-threonine phosphorylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of peptidyl-threonine phosphorylation. Peptidyl-threonine phosphorylation is the phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [GOC:dph, GOC:tb] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0010799 ! regulation of peptidyl-threonine phosphorylation relationship: negatively_regulates GO:0018107 ! peptidyl-threonine phosphorylation [Term] id: GO:0010803 name: regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway relationship: regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010804 name: negative regulation of tumor necrosis factor-mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate or extent of the tumor necrosis factor-mediated signaling pathway. The tumor necrosis factor-mediated signaling pathway is the series of molecular signals generated as a consequence of tumor necrosis factor binding to a cell surface receptor." [GOC:dph, GOC:tb] synonym: "negative regulation of TNF signaling" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of TNF-mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of tumor necrosis factor-mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0001960 ! negative regulation of cytokine-mediated signaling pathway is_a: GO:0010803 ! regulation of tumor necrosis factor-mediated signaling pathway relationship: negatively_regulates GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0010807 name: regulation of synaptic vesicle priming namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] subset: goslim_synapse is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010808 name: positive regulation of synaptic vesicle priming namespace: biological_process def: "Any process that increases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmv, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis relationship: positively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010809 name: negative regulation of synaptic vesicle priming namespace: biological_process def: "Any process that decreases the frequency, rate or extent of synaptic vesicle priming. Synaptic vesicle priming is the formation of SNARE-containing complexes, bringing synaptic vesicle membrane and plasma membranes into close proximity and thereby facilitating membrane fusion." [GOC:dph, GOC:kmvs, GOC:tb, PMID:15489511] is_a: GO:0010807 ! regulation of synaptic vesicle priming is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis relationship: negatively_regulates GO:0016082 ! synaptic vesicle priming [Term] id: GO:0010810 name: regulation of cell-substrate adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010811 name: positive regulation of cell-substrate adhesion namespace: biological_process def: "Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0010810 ! regulation of cell-substrate adhesion is_a: GO:0045785 ! positive regulation of cell adhesion relationship: positively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010812 name: negative regulation of cell-substrate adhesion namespace: biological_process def: "Any process that decreases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules." [GOC:dph, GOC:pf, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0010810 ! regulation of cell-substrate adhesion relationship: negatively_regulates GO:0031589 ! cell-substrate adhesion [Term] id: GO:0010813 name: neuropeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of neuropeptides. Neuropeptides are signaling peptides that travel across a synaptic junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010814 name: substance P catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the neuropeptide substance P." [GOC:BHF, GOC:rl] is_a: GO:0010813 ! neuropeptide catabolic process [Term] id: GO:0010815 name: bradykinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide bradykinin." [GOC:BHF, GOC:rl] is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010816 name: calcitonin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the peptide calcitonin." [GOC:BHF, GOC:rl] is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042447 ! hormone catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0010817 name: regulation of hormone levels namespace: biological_process def: "Any process that modulates the levels of hormone within an organism or a tissue. A hormone is any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0010818 name: T cell chemotaxis namespace: biological_process def: "The directed movement of a T cell in response to an external stimulus. A T cell is a type of lymphocyte whose defining characteristic is the expression of a T cell receptor complex." [GOC:dph, GOC:tb] synonym: "T-cell chemotaxis" EXACT [CL:0000084] is_a: GO:0048247 ! lymphocyte chemotaxis is_a: GO:0072678 ! T cell migration [Term] id: GO:0010819 name: regulation of T cell chemotaxis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:dph, GOC:tb] is_a: GO:1901623 ! regulation of lymphocyte chemotaxis is_a: GO:2000404 ! regulation of T cell migration relationship: regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010820 name: positive regulation of T cell chemotaxis namespace: biological_process def: "Any process that increases the rate, frequency or extent of T cell chemotaxis. T cell chemotaxis is the directed movement of a T cell in response to an external stimulus." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010819 ! regulation of T cell chemotaxis is_a: GO:0140131 ! positive regulation of lymphocyte chemotaxis is_a: GO:2000406 ! positive regulation of T cell migration relationship: positively_regulates GO:0010818 ! T cell chemotaxis [Term] id: GO:0010821 name: regulation of mitochondrion organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010822 name: positive regulation of mitochondrion organization namespace: biological_process def: "Any process that increases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "positive regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization relationship: positively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010823 name: negative regulation of mitochondrion organization namespace: biological_process def: "Any process that decreases the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a mitochondrion." [GOC:dph, GOC:tb] synonym: "negative regulation of mitochondrion organisation" EXACT [GOC:mah] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0010821 ! regulation of mitochondrion organization relationship: negatively_regulates GO:0007005 ! mitochondrion organization [Term] id: GO:0010824 name: regulation of centrosome duplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0046605 ! regulation of centrosome cycle relationship: regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010825 name: positive regulation of centrosome duplication namespace: biological_process def: "Any process that increases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010824 ! regulation of centrosome duplication is_a: GO:0046607 ! positive regulation of centrosome cycle relationship: positively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010826 name: negative regulation of centrosome duplication namespace: biological_process def: "Any process that decreases the frequency, rate or extent of centrosome duplication. Centrosome duplication is the replication of a centrosome, a structure comprised of a pair of centrioles and peri-centriolar material from which a microtubule spindle apparatus is organized." [GOC:dph, GOC:tb] is_a: GO:0010824 ! regulation of centrosome duplication is_a: GO:0046606 ! negative regulation of centrosome cycle relationship: negatively_regulates GO:0051298 ! centrosome duplication [Term] id: GO:0010827 name: regulation of glucose transmembrane transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] synonym: "regulation of glucose transport" RELATED [] is_a: GO:0034762 ! regulation of transmembrane transport relationship: regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010828 name: positive regulation of glucose transmembrane transport namespace: biological_process def: "Any process that increases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of glucose transmembrane transport is_a: GO:0034764 ! positive regulation of transmembrane transport relationship: positively_regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010829 name: negative regulation of glucose transmembrane transport namespace: biological_process def: "Any process that decreases the frequency, rate or extent of glucose transport across a membrane. Glucose transport is the directed movement of the hexose monosaccharide glucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of glucose transport" RELATED [] is_a: GO:0010827 ! regulation of glucose transmembrane transport is_a: GO:0034763 ! negative regulation of transmembrane transport relationship: negatively_regulates GO:1904659 ! glucose transmembrane transport [Term] id: GO:0010830 name: regulation of myotube differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0051153 ! regulation of striated muscle cell differentiation relationship: regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010831 name: positive regulation of myotube differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051155 ! positive regulation of striated muscle cell differentiation relationship: positively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010832 name: negative regulation of myotube differentiation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of myotube differentiation. Myotube differentiation is the process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:dph, GOC:tb] is_a: GO:0010830 ! regulation of myotube differentiation is_a: GO:0051154 ! negative regulation of striated muscle cell differentiation relationship: negatively_regulates GO:0014902 ! myotube differentiation [Term] id: GO:0010833 name: telomere maintenance via telomere lengthening namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and lengthening the telomeric DNA." [GOC:dph, GOC:tb] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0010834 name: obsolete telomere maintenance via telomere shortening namespace: biological_process def: "OBSOLETE. Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and shortening the telomeric DNA." [GOC:dph, GOC:tb] comment: This term was made obsolete because it represents a phenotype. synonym: "telomere maintenance via telomere shortening" EXACT [] is_obsolete: true consider: GO:1903824 [Term] id: GO:0010835 name: regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:dph, GOC:tb] synonym: "regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0031399 ! regulation of protein modification process relationship: regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010836 name: negative regulation of protein ADP-ribosylation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of protein ADP-ribosylation. Protein ADP-ribosylation is the transfer, from NAD, of ADP-ribose to protein amino acids." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of protein amino acid ADP-ribosylation" EXACT [GOC:bf] is_a: GO:0010835 ! regulation of protein ADP-ribosylation is_a: GO:0031400 ! negative regulation of protein modification process relationship: negatively_regulates GO:0006471 ! protein ADP-ribosylation [Term] id: GO:0010837 name: regulation of keratinocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0050678 ! regulation of epithelial cell proliferation relationship: regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010838 name: positive regulation of keratinocyte proliferation namespace: biological_process def: "Any process that increases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050679 ! positive regulation of epithelial cell proliferation relationship: positively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010839 name: negative regulation of keratinocyte proliferation namespace: biological_process def: "Any process that decreases the rate, frequency or extent of keratinocyte proliferation. Keratinocyte proliferation is the multiplication or reproduction of keratinocytes, resulting in the expansion of a cell population." [GOC:dph, GOC:tb] is_a: GO:0010837 ! regulation of keratinocyte proliferation is_a: GO:0050680 ! negative regulation of epithelial cell proliferation relationship: negatively_regulates GO:0043616 ! keratinocyte proliferation [Term] id: GO:0010840 name: regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:dph, GOC:tb] is_a: GO:0042749 ! regulation of circadian sleep/wake cycle relationship: regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010841 name: positive regulation of circadian sleep/wake cycle, wakefulness namespace: biological_process def: "Any process that increases the frequency, or extent of the wakeful phase of the circadian sleep/wake cycle. The wakeful phase is the part of the circadian sleep/wake cycle where the organism is not asleep." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010840 ! regulation of circadian sleep/wake cycle, wakefulness is_a: GO:0042753 ! positive regulation of circadian rhythm is_a: GO:0048520 ! positive regulation of behavior is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0042746 ! circadian sleep/wake cycle, wakefulness [Term] id: GO:0010842 name: retina layer formation namespace: biological_process def: "The process in which the vertebrate retina is organized into three laminae: the outer nuclear layer (ONL), which contains photoreceptor nuclei; the inner nuclear layer (INL), which contains amacrine, bipolar and horizontal cells; and the retinal ganglion cell (RGC) layer. Between the inner and outer nuclear layers, the outer plexiform layer (OPL) contains connections between the photoreceptors and bipolar and horizontal cells. The inner plexiform layer (IPL) is positioned between the INL and the ganglion cell layer and contains the dendrites of RGCs and processes of bipolar and amacrine cells. Spanning all layers of the retina are the radially oriented Mueller glia." [GOC:ascb_2009, GOC:dph, GOC:tb, PMID:1270266] synonym: "retinal lamination" EXACT [GOC:dph, GOC:tb] synonym: "retinal layer formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003407 ! neural retina development relationship: part_of GO:0060042 ! retina morphogenesis in camera-type eye [Term] id: GO:0010843 name: obsolete promoter binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with the regulatory region composed of the transcription start site and binding sites for transcription factor complexes of the basal transcription machinery." [GOC:dph, GOC:tb, SO:0000167] comment: This term was made obsolete because the word "promoter" is used ambiguously in the literature. It sometimes is used to refer specifically to the "core promoter" region recognized by the basal transcription machinery, and other times is used to refer to a larger regulatory region composed of the core promoter and also the regulatory region adjacent (proximal) to the core promoter. The core promoter proximal region is typically recognized by "regulatory transcription factors", such as Gal4 in S. cerevisiae. synonym: "DNA binding, transcription promoter" EXACT [GOC:dph, GOC:tb] synonym: "promoter binding" EXACT [] is_obsolete: true consider: GO:0001047 consider: GO:0044212 [Term] id: GO:0010844 name: recombination hotspot binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region in a genome which promotes recombination." [GOC:dph, GOC:tb] synonym: "DNA binding, recombination hotspot" EXACT [GOC:dph, GOC:tb] is_a: GO:0003677 ! DNA binding [Term] id: GO:0010845 name: positive regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that increases the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "positive regulation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination is_a: GO:0045911 ! positive regulation of DNA recombination is_a: GO:0060903 ! positive regulation of meiosis I relationship: positively_regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010846 name: activation of reciprocal meiotic recombination namespace: biological_process def: "Any process that starts the inactive process of reciprocal meiotic recombination. Reciprocal meiotic recombination is the cell cycle process in which double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] synonym: "activation of meiotic recombination" RELATED [GOC:dph, GOC:tb] is_a: GO:0010845 ! positive regulation of reciprocal meiotic recombination [Term] id: GO:0010847 name: regulation of chromatin assembly namespace: biological_process def: "Any process the modulates the frequency, rate or extent of chromatin assembly. Chromatin assembly is the assembly of DNA, histone proteins, and other associated proteins into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0031497 ! chromatin assembly [Term] id: GO:0010848 name: regulation of chromatin disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin disassembly. Chromatin disassembly is the controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, and other proteins." [GOC:dph, GOC:tb] is_a: GO:0001672 ! regulation of chromatin assembly or disassembly relationship: regulates GO:0031498 ! chromatin disassembly [Term] id: GO:0010849 name: regulation of proton-transporting ATPase activity, rotational mechanism namespace: biological_process def: "Any process that modulates the rate of ATP hydrolysis by an ATPase. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out), by a rotational mechanism." [GOC:dph, GOC:tb] synonym: "regulation of hydrogen ion transporting ATPase activity, rotational mechanism" EXACT [GOC:dph, GOC:tb] synonym: "regulation of V-type ATPase activity" BROAD [GOC:dph, GOC:tb] is_a: GO:0010155 ! regulation of proton transport is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0043462 ! regulation of ATPase activity [Term] id: GO:0010850 name: regulation of blood pressure by chemoreceptor signaling pathway namespace: biological_process def: "A series of reactions within the cell that occur as a result of a single trigger reaction or compound interacting with a chemoreceptor resulting in a modulation of the force with which blood travels through the circulatory system. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb] synonym: "regulation of blood pressure by chemoreceptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0010851 name: cyclase regulator activity namespace: molecular_function def: "Modulates the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0010852 name: cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010853 name: cyclase activator activity namespace: molecular_function def: "Increases the activity of an enzyme that catalyzes a ring closure reaction." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010854 name: adenylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0010855 name: adenylate cyclase inhibitor activity namespace: molecular_function def: "Decreases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0010854 ! adenylate cyclase regulator activity [Term] id: GO:0010856 name: adenylate cyclase activator activity namespace: molecular_function def: "Increases the activity of the enzyme that catalyzes the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [GOC:dph, GOC:tb] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0010857 name: calcium-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP. This reaction requires the presence of calcium." [GOC:dph, GOC:tb] xref: reactome:R-HSA-8986937 "MECP2 is phosphorylated at T308" xref: reactome:R-HSA-9005561 "Active PKA, CaMK IV do not phosphorylate MECP2 mutants R306C,(R306H) at T308" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0010858 name: calcium-dependent protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a calcium-dependent protein kinase, an enzyme which phosphorylates a protein in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0010859 name: calcium-dependent cysteine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile in a calcium-dependent manner." [GOC:dph, GOC:tb] is_a: GO:0004869 ! cysteine-type endopeptidase inhibitor activity [Term] id: GO:0010860 name: obsolete proteasome regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:dph, GOC:tb] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "proteasome regulator activity" EXACT [] is_obsolete: true consider: GO:0061135 consider: GO:0061136 [Term] id: GO:0010862 name: positive regulation of pathway-restricted SMAD protein phosphorylation namespace: biological_process def: "Any process that increases the rate, frequency or extent of pathway-restricted SMAD protein phosphorylation. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph, GOC:tb] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0060393 ! regulation of pathway-restricted SMAD protein phosphorylation is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0060389 ! pathway-restricted SMAD protein phosphorylation [Term] id: GO:0010863 name: positive regulation of phospholipase C activity namespace: biological_process def: "Any process that increases the rate of phospholipase C activity." [GOC:dph, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:1900274 ! regulation of phospholipase C activity [Term] id: GO:0010864 name: positive regulation of protein histidine kinase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of protein histidine kinase activity." [GOC:dph, GOC:tb] is_a: GO:0032110 ! regulation of protein histidine kinase activity is_a: GO:0045860 ! positive regulation of protein kinase activity [Term] id: GO:0010865 name: stipule development namespace: biological_process def: "The process whose specific outcome is the progression of the stipule over time, from its formation to the mature structure. A stipule is one of (usually) a pair of appendages at the bases of leaves in many broad-leaved angiosperms." [GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0010866 name: regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010867 name: positive regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "positive regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process relationship: positively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010868 name: negative regulation of triglyceride biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of triglyceride biosynthesis. Triglyceride biosynthesis is the collection of chemical reactions and pathways resulting in the formation of triglyceride, any triester of glycerol." [GOC:BHF, GOC:tb] synonym: "negative regulation of triacylglycerol biosynthetic process" EXACT [GOC:mah] is_a: GO:0010866 ! regulation of triglyceride biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process relationship: negatively_regulates GO:0019432 ! triglyceride biosynthetic process [Term] id: GO:0010869 name: regulation of receptor biosynthetic process namespace: biological_process def: "Any process that modulates the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010870 name: positive regulation of receptor biosynthetic process namespace: biological_process def: "Any process that increases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process relationship: positively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010871 name: negative regulation of receptor biosynthetic process namespace: biological_process def: "Any process that decreases the frequency or rate of receptor biosynthesis. Receptor biosynthesis is the collection of chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:BHF, GOC:tb] is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0010869 ! regulation of receptor biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process relationship: negatively_regulates GO:0032800 ! receptor biosynthetic process [Term] id: GO:0010872 name: regulation of cholesterol esterification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:dph, GOC:tb] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010873 name: positive regulation of cholesterol esterification namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol esterification. Cholesterol esterification is the lipid modification process in which a sterol ester is formed by the combination of a carboxylic acid (often a fatty acid) and cholesterol. In the blood this process is associated with the conversion of free cholesterol into cholesteryl ester, which is then sequestered into the core of a lipoprotein particle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010872 ! regulation of cholesterol esterification is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0034435 ! cholesterol esterification [Term] id: GO:0010874 name: regulation of cholesterol efflux namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0032374 ! regulation of cholesterol transport relationship: regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010875 name: positive regulation of cholesterol efflux namespace: biological_process def: "Any process that increases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010874 ! regulation of cholesterol efflux is_a: GO:0032376 ! positive regulation of cholesterol transport relationship: positively_regulates GO:0033344 ! cholesterol efflux [Term] id: GO:0010876 name: lipid localization namespace: biological_process def: "Any process in which a lipid is transported to, or maintained in, a specific location." [GOC:BHF, GOC:dph, GOC:tb] synonym: "lipid localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0010877 name: lipid transport involved in lipid storage namespace: biological_process def: "The directed movement of lipids into cells that is part of their accumulation and maintenance." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0019915 ! lipid storage [Term] id: GO:0010878 name: cholesterol storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "cholesterol sequestration" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of cholesterol" NARROW [GOC:dph, GOC:tb] is_a: GO:0019915 ! lipid storage [Term] id: GO:0010879 name: cholesterol transport involved in cholesterol storage namespace: biological_process def: "The directed movement of cholesterol into cells that is part of their accumulation and maintenance." [GOC:dph, GOC:tb] is_a: GO:0010877 ! lipid transport involved in lipid storage is_a: GO:0030301 ! cholesterol transport relationship: part_of GO:0010878 ! cholesterol storage [Term] id: GO:0010880 name: regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "Any process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol relationship: regulates GO:0014808 ! release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [Term] id: GO:0010881 name: regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0010882 ! regulation of cardiac muscle contraction by calcium ion signaling [Term] id: GO:0010882 name: regulation of cardiac muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardiac muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of cardiac muscle contraction by calcium ion signalling" EXACT [GOC:mah] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0055117 ! regulation of cardiac muscle contraction [Term] id: GO:0010883 name: regulation of lipid storage namespace: biological_process def: "Any process that modulates the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0065008 ! regulation of biological quality is_a: GO:1905952 ! regulation of lipid localization relationship: regulates GO:0019915 ! lipid storage [Term] id: GO:0010884 name: positive regulation of lipid storage namespace: biological_process def: "Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of lipid sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:1905954 ! positive regulation of lipid localization relationship: positively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010885 name: regulation of cholesterol storage namespace: biological_process def: "Any process that modulates the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage relationship: regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010886 name: positive regulation of cholesterol storage namespace: biological_process def: "Any process that increases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010885 ! regulation of cholesterol storage relationship: positively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010887 name: negative regulation of cholesterol storage namespace: biological_process def: "Any process that decreases the rate or extent of cholesterol storage. Cholesterol storage is the accumulation and maintenance in cells or tissues of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of cholesterol sequestration" NARROW [GOC:dph, GOC:tb] is_a: GO:0010885 ! regulation of cholesterol storage is_a: GO:0010888 ! negative regulation of lipid storage relationship: negatively_regulates GO:0010878 ! cholesterol storage [Term] id: GO:0010888 name: negative regulation of lipid storage namespace: biological_process def: "Any process that decreases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage is_a: GO:1905953 ! negative regulation of lipid localization relationship: negatively_regulates GO:0019915 ! lipid storage [Term] id: GO:0010889 name: regulation of sequestering of triglyceride namespace: biological_process def: "Any process that modulates the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "regulation of triacylglycerol sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010883 ! regulation of lipid storage relationship: regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010890 name: positive regulation of sequestering of triglyceride namespace: biological_process def: "Any process that increases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "positive regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "positive regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010884 ! positive regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride relationship: positively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010891 name: negative regulation of sequestering of triglyceride namespace: biological_process def: "Any process that decreases the rate, frequency or extent of sequestering of triglyceride. Triglyceride sequestration is the process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of sequestering of triacylglycerol" EXACT [GOC:mah] synonym: "negative regulation of triglyceride sequestration" EXACT [GOC:dph, GOC:tb] is_a: GO:0010888 ! negative regulation of lipid storage is_a: GO:0010889 ! regulation of sequestering of triglyceride relationship: negatively_regulates GO:0030730 ! sequestering of triglyceride [Term] id: GO:0010892 name: positive regulation of mitochondrial translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mitochondrial translation as a result of a stimulus indicating the organism is under stress." [GOC:dph, GOC:jp, GOC:tb, PMID:8830768] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0070131 ! positive regulation of mitochondrial translation [Term] id: GO:0010893 name: positive regulation of steroid biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:tb] is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process is_a: GO:0050810 ! regulation of steroid biosynthetic process relationship: positively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010894 name: negative regulation of steroid biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:BHF, GOC:tb] is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0050810 ! regulation of steroid biosynthetic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process relationship: negatively_regulates GO:0006694 ! steroid biosynthetic process [Term] id: GO:0010895 name: negative regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:tb] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032443 ! regulation of ergosterol biosynthetic process is_a: GO:0106119 ! negative reguation of sterol biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process relationship: negatively_regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0010896 name: regulation of triglyceride catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0050994 ! regulation of lipid catabolic process is_a: GO:0090207 ! regulation of triglyceride metabolic process relationship: regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010897 name: negative regulation of triglyceride catabolic process namespace: biological_process def: "Any process that decreases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "negative regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0090209 ! negative regulation of triglyceride metabolic process relationship: negatively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010898 name: positive regulation of triglyceride catabolic process namespace: biological_process def: "Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride." [GOC:rn, GOC:tb] synonym: "positive regulation of triacylglycerol catabolic process" EXACT [GOC:mah] is_a: GO:0010896 ! regulation of triglyceride catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process is_a: GO:0090208 ! positive regulation of triglyceride metabolic process relationship: positively_regulates GO:0019433 ! triglyceride catabolic process [Term] id: GO:0010899 name: regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0060696 ! regulation of phospholipid catabolic process relationship: regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010900 name: negative regulation of phosphatidylcholine catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of phosphatidylcholine catabolism. Phosphatidylcholine catabolic processes are the chemical reactions and pathways resulting in the breakdown of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:BHF, GOC:tb] is_a: GO:0010899 ! regulation of phosphatidylcholine catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process is_a: GO:0051172 ! negative regulation of nitrogen compound metabolic process is_a: GO:1903726 ! negative regulation of phospholipid metabolic process relationship: negatively_regulates GO:0034638 ! phosphatidylcholine catabolic process [Term] id: GO:0010901 name: regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010902 name: positive regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that increases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "positive regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051130 ! positive regulation of cellular component organization is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010903 name: negative regulation of very-low-density lipoprotein particle remodeling namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle remodeling. Very-low-density lipoprotein particle remodeling is the acquisition, loss or modification of a protein or lipid within a very-low-density lipoprotein particle, including the hydrolysis of triglyceride by hepatic lipase or lipoprotein lipase and the subsequent loss of free fatty acid." [GOC:tb] synonym: "negative regulation of VLDL remodeling" EXACT [GOC:tb] is_a: GO:0010901 ! regulation of very-low-density lipoprotein particle remodeling is_a: GO:0051129 ! negative regulation of cellular component organization is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0034372 ! very-low-density lipoprotein particle remodeling [Term] id: GO:0010904 name: regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010905 name: negative regulation of UDP-glucose catabolic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of UDP-glucose catabolism. UDP-glucose catabolic processes are the chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:BHF, GOC:tb] synonym: "negative regulation of UDP-glucose catabolism" EXACT [GOC:tb] is_a: GO:0010563 ! negative regulation of phosphorus metabolic process is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010904 ! regulation of UDP-glucose catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process relationship: negatively_regulates GO:0006258 ! UDP-glucose catabolic process [Term] id: GO:0010906 name: regulation of glucose metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010907 name: positive regulation of glucose metabolic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of glucose metabolism. Glucose metabolic processes are the chemical reactions and pathways involving glucose, the aldohexose gluco-hexose." [GOC:BHF, GOC:tb] synonym: "positive regulation of glucose metabolism" EXACT [GOC:tb] is_a: GO:0010676 ! positive regulation of cellular carbohydrate metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process relationship: positively_regulates GO:0006006 ! glucose metabolic process [Term] id: GO:0010908 name: regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010559 ! regulation of glycoprotein biosynthetic process relationship: regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010909 name: positive regulation of heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis. Heparan sulfate proteoglycan biosynthetic processes are the chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues." [GOC:dph, GOC:tb] is_a: GO:0010908 ! regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:1902730 ! positive regulation of proteoglycan biosynthetic process relationship: positively_regulates GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0010910 name: positive regulation of heparan sulfate proteoglycan biosynthesis by positive regulation of epimerase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of heparan sulfate proteoglycan biosynthesis by an increase in epimerase activity. This epimerase activity catalyzes the reaction that converts D-glucuronate into its diastereoisomer in heparan sulfate." [GOC:dph, GOC:tb] is_a: GO:0010909 ! positive regulation of heparan sulfate proteoglycan biosynthetic process is_a: GO:0010912 ! positive regulation of isomerase activity [Term] id: GO:0010911 name: regulation of isomerase activity namespace: biological_process def: "Any process that modulates the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0010912 name: positive regulation of isomerase activity namespace: biological_process def: "Any process that increases the activity of an isomerase. An isomerase catalyzes the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [GOC:dph, GOC:tb] is_a: GO:0010911 ! regulation of isomerase activity is_a: GO:0043085 ! positive regulation of catalytic activity [Term] id: GO:0010913 name: regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:1900376 ! regulation of secondary metabolite biosynthetic process relationship: regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010914 name: positive regulation of sterigmatocystin biosynthetic process namespace: biological_process def: "Any process that increases the rate, frequency, or extent of sterigmatocystin biosynthesis. Sterigmatocystin biosynthetic processes are the chemical reactions and pathways resulting in the formation of sterigmatocystin, a carcinogenic mycotoxin produced in high yields by strains of the common molds." [GOC:dph, GOC:tb] is_a: GO:0010913 ! regulation of sterigmatocystin biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:1900378 ! positive regulation of secondary metabolite biosynthetic process relationship: positively_regulates GO:0045461 ! sterigmatocystin biosynthetic process [Term] id: GO:0010915 name: regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010916 name: negative regulation of very-low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of very-low-density lipoprotein particle clearance. Very-low-density lipoprotein particle clearance is the process in which a very-low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] synonym: "negative regulation of VLDL clearance" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of VLDL particle clearance" EXACT [GOC:dph, GOC:tb] is_a: GO:0010915 ! regulation of very-low-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance relationship: negatively_regulates GO:0034447 ! very-low-density lipoprotein particle clearance [Term] id: GO:0010917 name: negative regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "reduction of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045837 ! negative regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010918 name: positive regulation of mitochondrial membrane potential namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of establishment or extent of a mitochondrial membrane potential, the electric potential existing across any mitochondrial membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:dph, GOC:tb] synonym: "elevation of mitochondrial membrane potential" EXACT [GOC:rph] is_a: GO:0045838 ! positive regulation of membrane potential is_a: GO:0051881 ! regulation of mitochondrial membrane potential [Term] id: GO:0010919 name: regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:BHF, GOC:dph, GOC:tb] synonym: "regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019220 ! regulation of phosphate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process relationship: regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010920 name: negative regulation of inositol phosphate biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of inositol phosphate biosynthesis. Inositol phosphate biosynthetic processes are the chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [GOC:dph, GOC:tb] synonym: "negative regulation of inositol phosphate biosynthesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045936 ! negative regulation of phosphate metabolic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process relationship: negatively_regulates GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0010921 name: regulation of phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0035303 ! regulation of dephosphorylation is_a: GO:0051336 ! regulation of hydrolase activity [Term] id: GO:0010922 name: positive regulation of phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0035306 ! positive regulation of dephosphorylation is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0010923 name: negative regulation of phosphatase activity namespace: biological_process def: "Any process that decreases the rate or frequency of phosphatase activity. Phosphatases catalyze the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity is_a: GO:0035305 ! negative regulation of dephosphorylation is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0010924 name: regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that modulates the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0010925 name: positive regulation of inositol-polyphosphate 5-phosphatase activity namespace: biological_process def: "Any process that increases the rate or frequency of inositol-polyphosphate 5-phosphatase activity, the catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0010924 ! regulation of inositol-polyphosphate 5-phosphatase activity [Term] id: GO:0010926 name: obsolete anatomical structure formation namespace: biological_process def: "OBSOLETE. The process pertaining to the initial formation of an anatomical structure from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structure is recognizable. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome." [GOC:dph, GOC:tb] comment: The reason for obsoletion is that the term is confusing - it sounds developmental and has a developmental sounding def, but it is not a child of developmental process and its children included 'cellular component assembly'. The term was created to group together 'cellular component assembly' and 'anatomical structure formation involved in morphogenesis', but we no longer feel that this grouping is useful. synonym: "anatomical structure formation" EXACT [] is_obsolete: true consider: GO:0022607 consider: GO:0048646 [Term] id: GO:0010927 name: cellular component assembly involved in morphogenesis namespace: biological_process def: "The cellular component assembly that is part of the initial shaping of the component during its developmental progression." [GOC:dph, GOC:tb] is_a: GO:0022607 ! cellular component assembly is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0032989 ! cellular component morphogenesis [Term] id: GO:0010928 name: regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that modulates the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010929 name: positive regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that increases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "positive regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway relationship: positively_regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010930 name: negative regulation of auxin mediated signaling pathway namespace: biological_process def: "Any process that decreases the rate, frequency or extent of auxin mediated signaling pathway. Auxin mediated signaling pathway is the series of molecular signals generated in response to detection of auxin." [GOC:dph, GOC:tb] synonym: "negative regulation of auxin mediated signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0010928 ! regulation of auxin mediated signaling pathway relationship: negatively_regulates GO:0009734 ! auxin-activated signaling pathway [Term] id: GO:0010931 name: macrophage tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in macrophages." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0010932 name: regulation of macrophage tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002643 ! regulation of tolerance induction relationship: regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010933 name: positive regulation of macrophage tolerance induction namespace: biological_process def: "Any process that increases the frequency, rate, or extent of B cell tolerance induction." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0010932 ! regulation of macrophage tolerance induction relationship: positively_regulates GO:0010931 ! macrophage tolerance induction [Term] id: GO:0010934 name: macrophage cytokine production namespace: biological_process def: "The appearance of a macrophage cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:dph, GOC:rl, GOC:tb] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0010935 name: regulation of macrophage cytokine production namespace: biological_process def: "Any process that modulates the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010936 name: negative regulation of macrophage cytokine production namespace: biological_process def: "Any process that decreases the rate, frequency or extent of macrophage cytokine production. Macrophage cytokine production is the appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:BHF, GOC:rl] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0010935 ! regulation of macrophage cytokine production relationship: negatively_regulates GO:0010934 ! macrophage cytokine production [Term] id: GO:0010937 name: regulation of cytoplasmic microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cytoplasmic microtubule depolymerization." [GOC:dph, GOC:tb] is_a: GO:0031114 ! regulation of microtubule depolymerization relationship: regulates GO:0010938 ! cytoplasmic microtubule depolymerization [Term] id: GO:0010938 name: cytoplasmic microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a cytoplasmic microtubule." [GOC:dph, GOC:tb] is_a: GO:0007019 ! microtubule depolymerization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0010939 name: regulation of necrotic cell death namespace: biological_process def: "Any process that modulates the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010941 ! regulation of cell death relationship: regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010940 name: positive regulation of necrotic cell death namespace: biological_process def: "Any process that increases the rate, frequency or extent of necrotic cell death. Necrotic cell death is a cell death process that is morphologically characterized by a gain in cell volume (oncosis), swelling of organelles, plasma membrane rupture and subsequent loss of intracellular contents." [PMID:16507998] is_a: GO:0010939 ! regulation of necrotic cell death is_a: GO:0010942 ! positive regulation of cell death relationship: positively_regulates GO:0070265 ! necrotic cell death [Term] id: GO:0010941 name: regulation of cell death namespace: biological_process def: "Any process that modulates the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0008219 ! cell death [Term] id: GO:0010942 name: positive regulation of cell death namespace: biological_process def: "Any process that increases the rate or frequency of cell death. Cell death is the specific activation or halting of processes within a cell so that its vital functions markedly cease, rather than simply deteriorating gradually over time, which culminates in cell death." [GOC:dph, GOC:tb] is_a: GO:0010941 ! regulation of cell death is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0008219 ! cell death [Term] id: GO:0010943 name: NADPH pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H2O = NMNH + ADP." [GOC:tb] is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0010944 name: negative regulation of transcription by competitive promoter binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA-dependent transcription using a mechanism that involves direct competition for interaction with a promoter binding site." [GOC:tb] is_a: GO:0045892 ! negative regulation of transcription, DNA-templated [Term] id: GO:0010945 name: CoA pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: coenzyme A + H2O = 3',5'-ADP + 4'-phosphopantetheine." [GOC:tb] is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0010946 name: regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010520 ! regulation of reciprocal meiotic recombination relationship: regulates GO:0000709 ! meiotic joint molecule formation [Term] id: GO:0010947 name: negative regulation of meiotic joint molecule formation namespace: biological_process def: "Any process that decreases the frequency, rate or extent of meiotic joint molecule formation. Meiotic joint molecule formation is the conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination." [GOC:dph, GOC:tb] is_a: GO:0010946 ! regulation of meiotic joint molecule formation is_a: GO:0045128 ! negative regulation of reciprocal meiotic recombination relationship: negatively_regulates GO:0000709 ! meiotic joint molecule formation [Term] id: GO:0010948 name: negative regulation of cell cycle process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events." [GOC:dph, GOC:tb] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle relationship: negatively_regulates GO:0022402 ! cell cycle process [Term] id: GO:0010949 name: negative regulation of intestinal phytosterol absorption namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of phytosterols into the blood by absorption from the small intestine." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:1904730 ! negative regulation of intestinal lipid absorption relationship: negatively_regulates GO:0060752 ! intestinal phytosterol absorption [Term] id: GO:0010950 name: positive regulation of endopeptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0010952 ! positive regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:0010951 name: negative regulation of endopeptidase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of endopeptidase activity, the endohydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] subset: goslim_chembl is_a: GO:0010466 ! negative regulation of peptidase activity is_a: GO:0052548 ! regulation of endopeptidase activity [Term] id: GO:0010952 name: positive regulation of peptidase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0051345 ! positive regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity [Term] id: GO:0010954 name: positive regulation of protein processing namespace: biological_process def: "Any process that increases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "positive regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045862 ! positive regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903319 ! positive regulation of protein maturation relationship: positively_regulates GO:0016485 ! protein processing [Term] id: GO:0010955 name: negative regulation of protein processing namespace: biological_process def: "Any process that decreases the rate, frequency or extent of protein maturation by peptide bond cleavage." [GOC:dph, GOC:mah, GOC:tb] synonym: "negative regulation of protein maturation by peptide bond cleavage" EXACT [GOC:bf] is_a: GO:0045861 ! negative regulation of proteolysis is_a: GO:0070613 ! regulation of protein processing is_a: GO:1903318 ! negative regulation of protein maturation relationship: negatively_regulates GO:0016485 ! protein processing [Term] id: GO:0010956 name: negative regulation of calcidiol 1-monooxygenase activity namespace: biological_process def: "Any process that decreases the rate, frequency or extent of calcidiol 1-monooxygenase activity. Calcidiol 1-monooxygenase activity is the catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010957 ! negative regulation of vitamin D biosynthetic process is_a: GO:0032353 ! negative regulation of hormone biosynthetic process is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0060558 ! regulation of calcidiol 1-monooxygenase activity is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process [Term] id: GO:0010957 name: negative regulation of vitamin D biosynthetic process namespace: biological_process def: "Any process that decreases the rate, frequency or extent of a vitamin D biosynthetic process. Vitamin D biosynthesis is the chemical reactions and pathways resulting in the formation of vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010894 ! negative regulation of steroid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0046137 ! negative regulation of vitamin metabolic process is_a: GO:0060556 ! regulation of vitamin D biosynthetic process relationship: negatively_regulates GO:0042368 ! vitamin D biosynthetic process [Term] id: GO:0010958 name: regulation of amino acid import across plasma membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of amino acid import into a cell." [GOC:dph, GOC:tb] synonym: "regulation of amino acid import" BROAD [] is_a: GO:1903789 ! regulation of amino acid transmembrane transport relationship: regulates GO:0089718 ! amino acid import across plasma membrane [Term] id: GO:0010959 name: regulation of metal ion transport namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of metal ion transport. Metal ion transport is the directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0043269 ! regulation of ion transport relationship: regulates GO:0030001 ! metal ion transport [Term] id: GO:0010960 name: magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions within an organism or cell." [GOC:dph, GOC:tb] is_a: GO:0055065 ! metal ion homeostasis is_a: GO:0072507 ! divalent inorganic cation homeostasis [Term] id: GO:0010961 name: cellular magnesium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of magnesium ions at the level of a cell." [GOC:dph, GOC:tb] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0010960 ! magnesium ion homeostasis is_a: GO:0072503 ! cellular divalent inorganic cation homeostasis [Term] id: GO:0010962 name: regulation of glucan biosynthetic process namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of glucan biosynthesis. Glucan biosynthetic processes are the chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:dph, GOC:tb] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process is_a: GO:2000112 ! regulation of cellular macromolecule biosynthetic process relationship: regulates GO:0009250 ! glucan biosynthetic process [Term] id: GO:0010963 name: regulation of L-arginine import namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-arginine import. L-arginine import is the directed movement of L-arginine, the L-enantiomer of 2-amino-5-guanidinopentanoic acid, into a cell or organelle." [GOC:dph, GOC:tb] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:2001023 ! regulation of response to drug relationship: regulates GO:1902023 ! L-arginine transport [Term] id: GO:0010964 name: regulation of chromatin silencing by small RNA namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin silencing by small RNA. Chromatin silencing by small RNA is the repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:tb] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0060966 ! regulation of gene silencing by RNA relationship: regulates GO:0031048 ! chromatin silencing by small RNA [Term] id: GO:0010965 name: regulation of mitotic sister chromatid separation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitotic sister chromatid separation. Mitotic sister chromatid separation is the process in which sister chromatids are physically detached from each other during mitosis." [GOC:dph, GOC:tb] is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:1905818 ! regulation of chromosome separation relationship: regulates GO:0051306 ! mitotic sister chromatid separation [Term] id: GO:0010966 name: regulation of phosphate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphate transport. Phosphate transport is the directed movement of phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:tb] is_a: GO:0044070 ! regulation of anion transport relationship: regulates GO:0006817 ! phosphate ion transport [Term] id: GO:0010967 name: regulation of polyamine biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polyamine biosynthesis. Polyamine biosynthesis is the chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [GOC:dph, GOC:tb] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006596 ! polyamine biosynthetic process [Term] id: GO:0010968 name: regulation of microtubule nucleation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [GOC:dph, GOC:tb] is_a: GO:0031113 ! regulation of microtubule polymerization relationship: regulates GO:0007020 ! microtubule nucleation [Term] id: GO:0010969 name: regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0060238 ! regulation of signal transduction involved in conjugation with cellular fusion relationship: regulates GO:0000750 ! pheromone-dependent signal transduction involved in conjugation with cellular fusion [Term] id: GO:0010970 name: transport along microtubule namespace: biological_process def: "The movement of organelles or other particles from one location in the cell to another along microtubules, driven by motor activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "establishment of localization by movement along microtubule" EXACT [GOC:dph] synonym: "microtubule-based transport" BROAD [] synonym: "movement along microtubule" EXACT [] is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport is_a: GO:0099111 ! microtubule-based transport [Term] id: GO:0010971 name: positive regulation of G2/M transition of mitotic cell cycle namespace: biological_process alt_id: GO:0031662 def: "Any signalling pathway that activates or increases the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:dph, GOC:mtg_cell_cycle, GOC:tb] synonym: "positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle" RELATED [] synonym: "positive regulation of mitotic entry" EXACT [GOC:mah] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition is_a: GO:1902751 ! positive regulation of cell cycle G2/M phase transition relationship: positively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010972 name: negative regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any signalling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G2 phase to M phase of the mitotic cell cycle." [GOC:mtg_cell_cycle] synonym: "negative regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle is_a: GO:1901991 ! negative regulation of mitotic cell cycle phase transition is_a: GO:1902750 ! negative regulation of cell cycle G2/M phase transition relationship: negatively_regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010973 name: positive regulation of division septum assembly namespace: biological_process alt_id: GO:1901912 alt_id: GO:1902470 def: "Any process that increases the frequency, rate or extent of division septum formation. division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "positive regulation of division septum formation" EXACT [] synonym: "positive regulation of division septum formation involved in cell cycle cytokinesis" EXACT [GOC:TermGenie] synonym: "upregulation of mitotic division septum assembly" EXACT [GOC:TermGenie] is_a: GO:0032955 ! regulation of division septum assembly is_a: GO:1901893 ! positive regulation of cell septum assembly relationship: positively_regulates GO:0000917 ! division septum assembly [Term] id: GO:0010974 name: negative regulation of division septum assembly namespace: biological_process alt_id: GO:1901139 alt_id: GO:1902469 def: "Any process that decreases the frequency, rate or extent of division septum formation. division septum formation is he assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "inhibition of division septum assembly involved in cell cycle cytokinesis" NARROW [GOC:TermGenie] synonym: "negative regulation of division septum formation" EXACT [] is_a: GO:0032955 ! regulation of division septum assembly is_a: GO:1901892 ! negative regulation of cell septum assembly relationship: negatively_regulates GO:0000917 ! division septum assembly [Term] id: GO:0010975 name: regulation of neuron projection development namespace: biological_process def: "Any process that modulates the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "regulation of neurite development" NARROW [GOC:mah] synonym: "regulation of neurite formation" NARROW [GOC:mah] synonym: "regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization relationship: regulates GO:0031175 ! neuron projection development [Term] id: GO:0010976 name: positive regulation of neuron projection development namespace: biological_process def: "Any process that increases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "positive regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "positive regulation of neurite development" NARROW [GOC:mah] synonym: "positive regulation of neurite formation" NARROW [GOC:mah] synonym: "positive regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031346 ! positive regulation of cell projection organization is_a: GO:0045666 ! positive regulation of neuron differentiation relationship: positively_regulates GO:0031175 ! neuron projection development [Term] id: GO:0010977 name: negative regulation of neuron projection development namespace: biological_process def: "Any process that decreases the rate, frequency or extent of neuron projection development. Neuron projection development is the process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:dph, GOC:tb] synonym: "growth cone collapse" RELATED [GOC:pr] synonym: "negative regulation of neurite biosynthesis" NARROW [GOC:mah] synonym: "negative regulation of neurite development" NARROW [GOC:mah] synonym: "negative regulation of neurite formation" NARROW [GOC:mah] synonym: "negative regulation of neurite growth" NARROW [GOC:mah] is_a: GO:0010975 ! regulation of neuron projection development is_a: GO:0031345 ! negative regulation of cell projection organization is_a: GO:0045665 ! negative regulation of neuron differentiation relationship: negatively_regulates GO:0031175 ! neuron projection development [Term] id: GO:0010978 name: gene silencing involved in chronological cell aging namespace: biological_process def: "Any transcriptional or post-transcriptional process, arising in non-dividing cells as they age, carried out at the cellular level that results in long-term gene inactivation." [GOC:dph, GOC:jp, GOC:tb] is_a: GO:0016458 ! gene silencing relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0010979 name: regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that modulates the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0010980 name: positive regulation of vitamin D 24-hydroxylase activity namespace: biological_process def: "Any process that increases the rate, frequency or extent of vitamin D 24-hydroxylase activity. Vitamin D 24-hydroxylase activity catalyzes the hydroxylation of C-24 of any form of vitamin D." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010979 ! regulation of vitamin D 24-hydroxylase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity [Term] id: GO:0010981 name: regulation of cell wall macromolecule metabolic process namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell wall macromolecule metabolism. Cell wall macromolecule metabolic processes are the chemical reactions and pathways involving macromolecules forming, or destined to form, part of the cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:tb] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process is_a: GO:1903338 ! regulation of cell wall organization or biogenesis relationship: regulates GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010982 name: regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010983 name: positive regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010986 ! positive regulation of lipoprotein particle clearance relationship: positively_regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010984 name: regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010985 name: negative regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010986 name: positive regulation of lipoprotein particle clearance namespace: biological_process def: "Any process that increases the rate, frequency, or extent of lipoprotein particle clearance. Lipoprotein particle clearance is the process in which a lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0034381 ! plasma lipoprotein particle clearance [Term] id: GO:0010987 name: negative regulation of high-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of high-density lipoprotein particle clearance. High-density lipoprotein particle clearance is the process in which a high-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010982 ! regulation of high-density lipoprotein particle clearance is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance relationship: negatively_regulates GO:0034384 ! high-density lipoprotein particle clearance [Term] id: GO:0010988 name: regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that modulates the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010984 ! regulation of lipoprotein particle clearance relationship: regulates GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0010989 name: negative regulation of low-density lipoprotein particle clearance namespace: biological_process def: "Any process that decreases the rate, frequency or extent of low-density lipoprotein particle clearance. Low-density lipoprotein particle clearance is the process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010985 ! negative regulation of lipoprotein particle clearance is_a: GO:0010988 ! regulation of low-density lipoprotein particle clearance relationship: negatively_regulates GO:0034383 ! low-density lipoprotein particle clearance [Term] id: GO:0010990 name: regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0007183 ! SMAD protein complex assembly [Term] id: GO:0010991 name: negative regulation of SMAD protein complex assembly namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of SMAD protein complex assembly. SMAD protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010990 ! regulation of SMAD protein complex assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0007183 ! SMAD protein complex assembly [Term] id: GO:0010992 name: ubiquitin recycling namespace: biological_process alt_id: GO:0010993 def: "Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates." [GOC:BHF, GOC:dph, GOC:PG, GOC:tb, PMID:19410548] synonym: "regulation of ubiquitin homeostasis" NARROW [] synonym: "ubiquitin homeostasis" RELATED [] is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0010994 name: free ubiquitin chain polymerization namespace: biological_process def: "The process of creating free ubiquitin chains, compounds composed of a large number of ubiquitin monomers. These chains are not conjugated to a protein." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0010992 ! ubiquitin recycling [Term] id: GO:0010995 name: free ubiquitin chain depolymerization namespace: biological_process def: "The process in which free ubiquitin chains, compounds composed of a large number of ubiquitin monomers, are broken down." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0010992 ! ubiquitin recycling [Term] id: GO:0010996 name: response to auditory stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auditory stimulus." [GOC:BHF, GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound" EXACT [GOC:dph, GOC:sl, GOC:tb] synonym: "response to sound stimulus" EXACT [GOC:dph, GOC:tb] is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0010997 name: anaphase-promoting complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis." [GOC:BHF, GOC:dph, GOC:tb] synonym: "APC binding" EXACT [GOC:dph, GOC:tb] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0010998 name: regulation of translational initiation by eIF2 alpha phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the phosphorylation of eIF2 alpha." [GOC:BHF, GOC:dph, GOC:hjd, GOC:tb] comment: Consider also annotating to 'eukaryotic translation initiation factor 2alpha kinase activity ; GO:0004694'. synonym: "eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] synonym: "regulation of translational initiation by eIF2 alpha phosphorylation in response to stress" EXACT [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0043558 ! regulation of translational initiation in response to stress [Term] id: GO:0010999 name: regulation of eIF2 alpha phosphorylation by heme namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of eIF2 alpha phosphorylation as a result of heme levels." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0001932 ! regulation of protein phosphorylation is_a: GO:0006446 ! regulation of translational initiation is_a: GO:0080135 ! regulation of cellular response to stress relationship: regulates GO:0010998 ! regulation of translational initiation by eIF2 alpha phosphorylation [Term] id: GO:0011000 name: replication fork arrest at mating type locus namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the mating type locus." [GOC:dph, GOC:tb] is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0012501 name: programmed cell death namespace: biological_process alt_id: GO:0016244 def: "A process which begins when a cell receives an internal or external signal and activates a series of biochemical events (signaling pathway). The process ends with the death of the cell." [GOC:lr, GOC:mtg_apoptosis] comment: Note that this term should be used to annotate gene products in the organism undergoing the programmed cell death. To annotate genes in another organism whose products modulate programmed cell death in a host organism, consider the term 'modulation by symbiont of host programmed cell death ; GO:0052040'. Also, note that 'programmed cell death ; GO:0012501' should be used to refer to instances of caspase-independent cell death mechanisms, in the absence of further indications on the process taking place. At present, caspase-independent cell death is not yet represented in GO due to the lack of consensus and in-depth research on the topic. 'programmed cell death ; GO:0012501' may also be used to annotate gene products in taxa where apoptosis as defined in GO:0006915 does not occur, such as plants. You may also consider these specific children: GO:0097468 'programmed cell death in response to reactive oxygen species' (with descendants GO:0010421 'hydrogen peroxide-mediated programmed cell death' and GO:0010343 'singlet oxygen-mediated programmed cell death'), and GO:0009626 'plant-type hypersensitive response' and its children. synonym: "caspase-independent apoptosis" RELATED [] synonym: "caspase-independent cell death" NARROW [] synonym: "non-apoptotic programmed cell death" NARROW [] synonym: "nonapoptotic programmed cell death" NARROW [] synonym: "PCD" RELATED [] synonym: "RCD" RELATED [] synonym: "regulated cell death" BROAD [] xref: Wikipedia:Programmed_cell_death is_a: GO:0008219 ! cell death [Term] id: GO:0012502 name: induction of programmed cell death namespace: biological_process alt_id: GO:0012503 def: "A process which directly activates any of the steps required for programmed cell death." [GOC:lr] synonym: "induction of non-apoptotic programmed cell death" NARROW [] synonym: "induction of nonapoptotic programmed cell death" NARROW [] is_a: GO:0043068 ! positive regulation of programmed cell death [Term] id: GO:0012505 name: endomembrane system namespace: cellular_component def: "A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles." [GOC:lh] subset: goslim_aspergillus subset: goslim_candida subset: goslim_flybase_ribbon subset: goslim_yeast xref: Wikipedia:Endomembrane_system is_a: GO:0044464 ! cell part [Term] id: GO:0012506 name: vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding any membrane-bounded vesicle in the cell." [GOC:mah, GOC:vesicle] xref: NIF_Subcellular:sao1153182838 is_a: GO:0031090 ! organelle membrane relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0012507 name: ER to Golgi transport vesicle membrane namespace: cellular_component alt_id: GO:0030664 def: "The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi." [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "COPII coated vesicle membrane" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle membrane" EXACT [] synonym: "endoplasmic reticulum-Golgi transport vesicle membrane" EXACT [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "ER-Golgi transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030134 ! COPII-coated ER to Golgi transport vesicle [Term] id: GO:0012508 name: Golgi to ER transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances from the Golgi to the ER." [GOC:ai] synonym: "Golgi to endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi to ER constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle membrane" EXACT [] synonym: "Golgi-ER transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI-coated vesicle membrane relationship: part_of GO:0030142 ! COPI-coated Golgi to ER transport vesicle [Term] id: GO:0012509 name: inter-Golgi transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances within the Golgi." [GOC:ai] synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030663 ! COPI-coated vesicle membrane relationship: part_of GO:0030143 ! COPI-coated inter-Golgi transport vesicle [Term] id: GO:0012510 name: trans-Golgi network transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle transporting substances between the trans-Golgi network and other parts of the cell." [GOC:ai] synonym: "TGN transport vesicle membrane" EXACT [] synonym: "trans-Golgi network constitutive secretory pathway transport vesicle membrane" EXACT [] is_a: GO:0030658 ! transport vesicle membrane is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030665 ! clathrin-coated vesicle membrane relationship: part_of GO:0030140 ! trans-Golgi network transport vesicle [Term] id: GO:0012511 name: monolayer-surrounded lipid storage body namespace: cellular_component alt_id: GO:0009520 def: "A subcellular organelle of plant cells surrounded by 'half-unit' or a monolayer membrane instead of the more usual bilayer. The storage body has a droplet of triglyceride surrounded by a monolayer of phospholipids, interacting with the triglycerides and the hydrophilic head groups facing the cytosol, and containing major protein components called oleosins." [GOC:mtg_sensu, ISBN:0943088372] synonym: "oil body" EXACT [] synonym: "oilbody" EXACT [] synonym: "oleosome" EXACT [] synonym: "spherosome" EXACT [] xref: Wikipedia:Oil_body is_a: GO:0005811 ! lipid droplet [Term] id: GO:0014001 name: sclerenchyma cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sclerenchyma cell. A sclerenchyma cell is a plant cell with thick lignified walls, normally dead at maturity and specialized for structural strength. Includes fiber cells, that are greatly elongated; and sclereids, that are more isodiametric. Intermediate types exist. Cells may or may not be devoid of protoplasm at maturity. Cell form and size are variable." [CL:0000276, GOC:ef, GOC:jid, PO:0000077] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0014002 name: astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GOC:dgh, GOC:ef] synonym: "astrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048708 ! astrocyte differentiation [Term] id: GO:0014003 name: oligodendrocyte development namespace: biological_process def: "The process aimed at the progression of an oligodendrocyte over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. An oligodendrocyte is a type of glial cell involved in myelinating the axons in the central nervous system." [GOC:dgh, GOC:ef] synonym: "oligodendrocyte cell development" EXACT [] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0014004 name: microglia differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a microglial cell. Microglia are glial cells that act as the immune cells of the central nervous system. They form part of the supporting structure of this system." [GOC:ef] synonym: "microglial cell differentiation" EXACT [] is_a: GO:0010001 ! glial cell differentiation is_a: GO:0030225 ! macrophage differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014005 name: microglia development namespace: biological_process def: "The process aimed at the progression of a microglial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dgh, GOC:ef] synonym: "microglial cell development" EXACT [] is_a: GO:0021782 ! glial cell development is_a: GO:0061515 ! myeloid cell development relationship: part_of GO:0014004 ! microglia differentiation [Term] id: GO:0014006 name: regulation of microglia differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "regulation of microglial cell differentiation" EXACT [] is_a: GO:0045649 ! regulation of macrophage differentiation is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014007 name: negative regulation of microglia differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "down regulation of microglia differentiation" EXACT [] synonym: "down-regulation of microglia differentiation" EXACT [] synonym: "downregulation of microglia differentiation" EXACT [] synonym: "inhibition of microglia differentiation" NARROW [] synonym: "negative regulation of microglial cell differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045650 ! negative regulation of macrophage differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation relationship: negatively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014008 name: positive regulation of microglia differentiation namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of microglia differentiation, the process in which a relatively unspecialized cell acquires specialized features of a microglial cell." [GOC:ef] synonym: "activation of microglia differentiation" NARROW [] synonym: "positive regulation of microglial cell differentiation" EXACT [] synonym: "stimulation of microglia differentiation" NARROW [] synonym: "up regulation of microglia differentiation" EXACT [] synonym: "up-regulation of microglia differentiation" EXACT [] synonym: "upregulation of microglia differentiation" EXACT [] is_a: GO:0014006 ! regulation of microglia differentiation is_a: GO:0045651 ! positive regulation of macrophage differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation relationship: positively_regulates GO:0014004 ! microglia differentiation [Term] id: GO:0014009 name: glial cell proliferation namespace: biological_process def: "The multiplication or reproduction of glial cells by cell division, resulting in the expansion of their population. Glial cells exist throughout the nervous system, and include Schwann cells, astrocytes, and oligodendrocytes among others." [GOC:ef, ISBN:0878932585] synonym: "glia proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0014010 name: Schwann cell proliferation namespace: biological_process def: "The multiplication or reproduction of Schwann cells, resulting in the expansion of their population. Schwann cells are a type of glial cell in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014009 ! glial cell proliferation [Term] id: GO:0014011 name: Schwann cell proliferation involved in axon regeneration namespace: biological_process def: "The multiplication or reproduction of Schwann cells by cell division, resulting in the expansion of their population in response to an axonal lesion. The newly generated Schwann cells support subsequent axon regeneration in the peripheral nervous system." [GOC:ef, ISBN:0878932585] is_a: GO:0014010 ! Schwann cell proliferation relationship: part_of GO:0014012 ! peripheral nervous system axon regeneration [Term] id: GO:0014012 name: peripheral nervous system axon regeneration namespace: biological_process def: "The regrowth of axons outside the central nervous system (outside the brain and spinal cord) following an axonal injury." [GOC:ef] synonym: "axon regeneration in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014013 name: regulation of gliogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] is_a: GO:0050767 ! regulation of neurogenesis relationship: regulates GO:0042063 ! gliogenesis [Term] id: GO:0014014 name: negative regulation of gliogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "down regulation of gliogenesis" EXACT [] synonym: "down-regulation of gliogenesis" EXACT [] synonym: "downregulation of gliogenesis" EXACT [] synonym: "inhibition of gliogenesis" NARROW [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050768 ! negative regulation of neurogenesis relationship: negatively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014015 name: positive regulation of gliogenesis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gliogenesis, the formation of mature glia." [GOC:ef] synonym: "activation of gliogenesis" NARROW [] synonym: "stimulation of gliogenesis" NARROW [] synonym: "up regulation of gliogenesis" EXACT [] synonym: "up-regulation of gliogenesis" EXACT [] synonym: "upregulation of gliogenesis" EXACT [] is_a: GO:0014013 ! regulation of gliogenesis is_a: GO:0050769 ! positive regulation of neurogenesis relationship: positively_regulates GO:0042063 ! gliogenesis [Term] id: GO:0014016 name: neuroblast differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuroblast. There are at least four stages through which the pluripotent cells of epiblast or blastula become neuroblasts." [GOC:ef, ISBN:0878932585] is_a: GO:0048863 ! stem cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0014017 name: neuroblast fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will differentiate into a neuroblast." [GOC:ef, ISBN:0878932585] is_a: GO:0048865 ! stem cell fate commitment relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014018 name: neuroblast fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neuroblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, ISBN:0878932585] is_a: GO:0048866 ! stem cell fate specification relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0014019 name: neuroblast development namespace: biological_process def: "The process aimed at the progression of a neuroblast over time, from initial commitment of the cell to a specific state, to the mature neuroblast. It does not include processes where the neuroblast turns into a glial cell or a neuron." [GOC:ef, ISBN:0878932585] is_a: GO:0048864 ! stem cell development relationship: part_of GO:0014016 ! neuroblast differentiation [Term] id: GO:0014020 name: primary neural tube formation namespace: biological_process def: "The formation of the neural tube from an epithelial cell sheet (the neuroepithelium or neural plate). In primary neurulation, the cells surrounding the neural plate direct the neural plate cells to proliferate, invaginate, and pinch off from the surface to form a hollow epithelial tube. Primary neurulation is the typical mechanism of formation of the anterior neural tube." [GOC:ef, ISBN:0878932585] synonym: "primary neural tube morphogenesis" EXACT [GOC:dph] synonym: "primary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014021 name: secondary neural tube formation namespace: biological_process alt_id: GO:0014026 def: "The formation of the neural tube by coalescence of mesenchymal cells followed by their conversion to epithelial cells to form a solid cord that subsequently hollows out (cavitates) to create a hollow tube. Secondary neurulation is the typical mechanism of formation of the neural tube posterior to the posterior neuropore in mammals." [GOC:ef, ISBN:0878932585] synonym: "medullary cord biosynthesis" EXACT [] synonym: "medullary cord formation" EXACT [] synonym: "neural rod formation" RELATED [] synonym: "secondary neurulation" EXACT [] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0014022 name: neural plate elongation namespace: biological_process def: "The process in which the neural plate is shaped by the intrinsic movement of the epidermal and neural plate regions." [GOC:ef, ISBN:0878932585] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0014023 name: neural rod formation namespace: biological_process def: "The formation of a solid rod of neurectoderm derived from the neural keel. The neural rod is roughly circular in cross section. Neural rod formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014024 name: neural rod cavitation namespace: biological_process def: "The process of rod cavitation, which is the formation of a lumen in the neural rod during primary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0014025 name: neural keel formation namespace: biological_process def: "The formation of a thickened region of the neurectoderm that is roughly triangular in cross section. The neural keel develops from the neural plate and develops into the neural rod. Neural keel formation occurs during primary neurulation in teleosts." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0014023 ! neural rod formation [Term] id: GO:0014027 name: secondary neural tube rod cavitation namespace: biological_process def: "The process of medullary cavitation, which is the formation of a lumen in the medullary cord during secondary neurulation, producing the neural tube." [GOC:ef, PMID:15327780] synonym: "medullary rod cavitation" EXACT [] is_a: GO:0060605 ! tube lumen cavitation relationship: part_of GO:0014021 ! secondary neural tube formation [Term] id: GO:0014028 name: notochord formation namespace: biological_process def: "The formation of the notochord from the chordamesoderm. The notochord is composed of large cells packed within a firm connective tissue sheath and is found in all chordates at the ventral surface of the neural tube. In vertebrates, the notochord contributes to the vertebral column." [GOC:dh, GOC:ef] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0048570 ! notochord morphogenesis [Term] id: GO:0014029 name: neural crest formation namespace: biological_process def: "The formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes." [GOC:dh, GOC:ef] is_a: GO:0001837 ! epithelial to mesenchymal transition is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0014030 name: mesenchymal cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a mesenchymal cell." [GOC:dh, GOC:ef] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014031 name: mesenchymal cell development namespace: biological_process def: "The process aimed at the progression of a mesenchymal cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0048468 ! cell development relationship: part_of GO:0048762 ! mesenchymal cell differentiation [Term] id: GO:0014032 name: neural crest cell development namespace: biological_process def: "The process aimed at the progression of a neural crest cell over time, from initial commitment of the cell to its specific fate, to the fully functional differentiated cell." [GOC:dh, GOC:ef] is_a: GO:0014031 ! mesenchymal cell development is_a: GO:0048864 ! stem cell development relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014033 name: neural crest cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048762 ! mesenchymal cell differentiation is_a: GO:0048863 ! stem cell differentiation [Term] id: GO:0014034 name: neural crest cell fate commitment namespace: biological_process def: "The process in which a cell becomes committed to become a neural crest cell." [GOC:dh, GOC:ef] is_a: GO:0048865 ! stem cell fate commitment relationship: part_of GO:0014029 ! neural crest formation relationship: part_of GO:0014033 ! neural crest cell differentiation [Term] id: GO:0014035 name: neural crest cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:dh, GOC:ef] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014036 name: neural crest cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a neural crest cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:dh, GOC:ef] is_a: GO:0048866 ! stem cell fate specification relationship: part_of GO:0014034 ! neural crest cell fate commitment [Term] id: GO:0014037 name: Schwann cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a Schwann cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:ef] is_a: GO:0010001 ! glial cell differentiation relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0014038 name: regulation of Schwann cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] is_a: GO:0045685 ! regulation of glial cell differentiation relationship: regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014039 name: negative regulation of Schwann cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "down regulation of Schwann cell differentiation" EXACT [] synonym: "down-regulation of Schwann cell differentiation" EXACT [] synonym: "downregulation of Schwann cell differentiation" EXACT [] synonym: "inhibition of Schwann cell differentiation" NARROW [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045686 ! negative regulation of glial cell differentiation relationship: negatively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014040 name: positive regulation of Schwann cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Schwann cell differentiation." [GOC:ef] synonym: "activation of Schwann cell differentiation" NARROW [] synonym: "stimulation of Schwann cell differentiation" NARROW [] synonym: "up regulation of Schwann cell differentiation" EXACT [] synonym: "up-regulation of Schwann cell differentiation" EXACT [] synonym: "upregulation of Schwann cell differentiation" EXACT [] is_a: GO:0014038 ! regulation of Schwann cell differentiation is_a: GO:0045687 ! positive regulation of glial cell differentiation relationship: positively_regulates GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014041 name: regulation of neuron maturation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of neuron maturation, the process leading to the attainment of the full functional capacity of a neuron. This process is independent of morphogenetic change." [GOC:ef] is_a: GO:0045664 ! regulation of neuron differentiation is_a: GO:1903429 ! regulation of cell maturation relationship: regulates GO:0042551 ! neuron maturation [Term] id: GO:0014042 name: positive regulation of neuron maturation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "activation of neuron maturation" NARROW [] synonym: "stimulation of neuron maturation" NARROW [] synonym: "up regulation of neuron maturation" EXACT [] synonym: "up-regulation of neuron maturation" EXACT [] synonym: "upregulation of neuron maturation" EXACT [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045666 ! positive regulation of neuron differentiation is_a: GO:1903431 ! positive regulation of cell maturation relationship: positively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014043 name: negative regulation of neuron maturation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of neuron maturation." [GOC:ef] synonym: "down regulation of neuron maturation" EXACT [] synonym: "down-regulation of neuron maturation" EXACT [] synonym: "downregulation of neuron maturation" EXACT [] synonym: "inhibition of neuron maturation" NARROW [] is_a: GO:0014041 ! regulation of neuron maturation is_a: GO:0045665 ! negative regulation of neuron differentiation is_a: GO:1903430 ! negative regulation of cell maturation relationship: negatively_regulates GO:0042551 ! neuron maturation [Term] id: GO:0014044 name: Schwann cell development namespace: biological_process def: "The process aimed at the progression of a Schwann cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Schwann cells are found in the peripheral nervous system, where they insulate neurons and axons, and regulate the environment in which neurons function." [GOC:dgh, GOC:ef] is_a: GO:0021782 ! glial cell development relationship: part_of GO:0014037 ! Schwann cell differentiation [Term] id: GO:0014045 name: establishment of endothelial blood-brain barrier namespace: biological_process def: "Establishment of the endothelial barrier between the blood and the brain. The endothelial cells in the brain capillaries are packed tightly together preventing the passage of most molecules from the blood into the brain. Only lipid soluble molecules or those that are actively transported can pass through the blood-brain barrier." [GOC:dgh, GOC:dph, GOC:sart] synonym: "establishment of endothelial BBB" EXACT [PMID:20080302] synonym: "establishment of endothelial blood/brain barrier" EXACT [] is_a: GO:0060856 ! establishment of blood-brain barrier is_a: GO:0061028 ! establishment of endothelial barrier relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0014046 name: dopamine secretion namespace: biological_process def: "The regulated release of dopamine by a cell. Dopamine is a catecholamine and a precursor of adrenaline and noradrenaline. It acts as a neurotransmitter in the central nervous system but it is also produced peripherally and acts as a hormone." [GOC:ef] is_a: GO:0015872 ! dopamine transport is_a: GO:0050432 ! catecholamine secretion [Term] id: GO:0014047 name: glutamate secretion namespace: biological_process def: "The controlled release of glutamate by a cell. The glutamate is the most abundant excitatory neurotransmitter in the nervous system." [GOC:ef] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:0032940 ! secretion by cell is_a: GO:0046717 ! acid secretion [Term] id: GO:0014048 name: regulation of glutamate secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] is_a: GO:0051955 ! regulation of amino acid transport is_a: GO:1903530 ! regulation of secretion by cell relationship: regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014049 name: positive regulation of glutamate secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "activation of glutamate secretion" NARROW [] synonym: "stimulation of glutamate secretion" NARROW [] synonym: "up regulation of glutamate secretion" EXACT [] synonym: "up-regulation of glutamate secretion" EXACT [] synonym: "upregulation of glutamate secretion" EXACT [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0051957 ! positive regulation of amino acid transport is_a: GO:1903532 ! positive regulation of secretion by cell relationship: positively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014050 name: negative regulation of glutamate secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of glutamate." [GOC:ef] synonym: "down regulation of glutamate secretion" EXACT [] synonym: "down-regulation of glutamate secretion" EXACT [] synonym: "downregulation of glutamate secretion" EXACT [] synonym: "inhibition of glutamate secretion" NARROW [] is_a: GO:0014048 ! regulation of glutamate secretion is_a: GO:0051956 ! negative regulation of amino acid transport is_a: GO:1903531 ! negative regulation of secretion by cell relationship: negatively_regulates GO:0014047 ! glutamate secretion [Term] id: GO:0014051 name: gamma-aminobutyric acid secretion namespace: biological_process def: "The regulated release of gamma-aminobutyric acid by a cell or a tissue. The gamma-aminobutyric acid is the principal inhibitory neurotransmitter in the brain but is also found in several extraneural tissues." [GOC:ef] synonym: "GABA secretion" EXACT [] is_a: GO:0015812 ! gamma-aminobutyric acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0014052 name: regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "regulation of GABA secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:0051955 ! regulation of amino acid transport relationship: regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014053 name: negative regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "down regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "down-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "downregulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "inhibition of gamma-aminobutyric acid secretion" NARROW [] synonym: "negative regulation of GABA secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:0051956 ! negative regulation of amino acid transport relationship: negatively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014054 name: positive regulation of gamma-aminobutyric acid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of gamma-aminobutyric acid." [GOC:ef] synonym: "activation of gamma-aminobutyric acid secretion" NARROW [] synonym: "positive regulation of GABA secretion" EXACT [] synonym: "stimulation of gamma-aminobutyric acid secretion" NARROW [] synonym: "up regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "up-regulation of gamma-aminobutyric acid secretion" EXACT [] synonym: "upregulation of gamma-aminobutyric acid secretion" EXACT [] is_a: GO:0014052 ! regulation of gamma-aminobutyric acid secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:0051957 ! positive regulation of amino acid transport relationship: positively_regulates GO:0014051 ! gamma-aminobutyric acid secretion [Term] id: GO:0014055 name: acetylcholine secretion, neurotransmission namespace: biological_process def: "The regulated release of acetylcholine by a cell. The acetylcholine acts as a neurotransmitter that acts in both the peripheral nervous system (PNS) and central nervous system (CNS)." [GOC:ef] is_a: GO:0007269 ! neurotransmitter secretion is_a: GO:0061526 ! acetylcholine secretion relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0014056 name: regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0043269 ! regulation of ion transport is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0051952 ! regulation of amine transport is_a: GO:2001023 ! regulation of response to drug relationship: regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014057 name: positive regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "activation of acetylcholine secretion" NARROW [] synonym: "stimulation of acetylcholine secretion" NARROW [] synonym: "up regulation of acetylcholine secretion" EXACT [] synonym: "up-regulation of acetylcholine secretion" EXACT [] synonym: "upregulation of acetylcholine secretion" EXACT [] is_a: GO:0001956 ! positive regulation of neurotransmitter secretion is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032224 ! positive regulation of synaptic transmission, cholinergic is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051954 ! positive regulation of amine transport is_a: GO:2001025 ! positive regulation of response to drug relationship: positively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014058 name: negative regulation of acetylcholine secretion, neurotransmission namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of acetylcholine." [GOC:ef] synonym: "down regulation of acetylcholine secretion" EXACT [] synonym: "down-regulation of acetylcholine secretion" EXACT [] synonym: "downregulation of acetylcholine secretion" EXACT [] synonym: "inhibition of acetylcholine secretion" NARROW [] is_a: GO:0014056 ! regulation of acetylcholine secretion, neurotransmission is_a: GO:0032223 ! negative regulation of synaptic transmission, cholinergic is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0046929 ! negative regulation of neurotransmitter secretion is_a: GO:0051953 ! negative regulation of amine transport is_a: GO:2001024 ! negative regulation of response to drug relationship: negatively_regulates GO:0014055 ! acetylcholine secretion, neurotransmission [Term] id: GO:0014059 name: regulation of dopamine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of dopamine." [GOC:ef] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0050433 ! regulation of catecholamine secretion is_a: GO:2001023 ! regulation of response to drug relationship: regulates GO:0014046 ! dopamine secretion [Term] id: GO:0014060 name: regulation of epinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of epinephrine." [GOC:ef] synonym: "regulation of adrenaline secretion" EXACT [] is_a: GO:0046883 ! regulation of hormone secretion is_a: GO:0050433 ! regulation of catecholamine secretion relationship: regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0014061 name: regulation of norepinephrine secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of norepinephrine." [GOC:ef] synonym: "regulation of noradrenaline secretion" EXACT [] is_a: GO:0050433 ! regulation of catecholamine secretion relationship: regulates GO:0048243 ! norepinephrine secretion [Term] id: GO:0014062 name: regulation of serotonin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0043269 ! regulation of ion transport is_a: GO:0051588 ! regulation of neurotransmitter transport is_a: GO:1903530 ! regulation of secretion by cell relationship: regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014063 name: negative regulation of serotonin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "down regulation of serotonin secretion" EXACT [] synonym: "down-regulation of serotonin secretion" EXACT [] synonym: "downregulation of serotonin secretion" EXACT [] synonym: "inhibition of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051589 ! negative regulation of neurotransmitter transport is_a: GO:1903531 ! negative regulation of secretion by cell relationship: negatively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014064 name: positive regulation of serotonin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of serotonin." [GOC:ef] synonym: "activation of serotonin secretion" NARROW [] synonym: "positive regulation of serotonin release" RELATED [GOC:tb] synonym: "stimulation of serotonin secretion" NARROW [] synonym: "up regulation of serotonin secretion" EXACT [] synonym: "up-regulation of serotonin secretion" EXACT [] synonym: "upregulation of serotonin secretion" EXACT [] is_a: GO:0014062 ! regulation of serotonin secretion is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051590 ! positive regulation of neurotransmitter transport is_a: GO:1903532 ! positive regulation of secretion by cell relationship: positively_regulates GO:0001820 ! serotonin secretion [Term] id: GO:0014065 name: phosphatidylinositol 3-kinase signaling namespace: biological_process def: "A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions." [GOC:ef, http://www.biocarta.com, PMID:22525052, Wikipedia:PI3K] synonym: "phosphatidylinositol 3-kinase cascade" RELATED [GOC:signaling] synonym: "phosphatidylinositol 3-kinase signal transduction" EXACT [GOC:signaling] synonym: "phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "PI 3-kinase cascade" EXACT [] synonym: "PI3K cascade" EXACT [] synonym: "PI3K signal transduction" EXACT [GOC:signaling] synonym: "PI3K signaling" EXACT [GOC:signaling] is_a: GO:0048015 ! phosphatidylinositol-mediated signaling [Term] id: GO:0014066 name: regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "regulation of PI 3-kinase cascade" RELATED [] synonym: "regulation of PI3K cascade" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction relationship: regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014067 name: negative regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "down regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "down-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "downregulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "inhibition of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "negative regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "negative regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "negative regulation of PI 3-kinase cascade" EXACT [] synonym: "negative regulation of PI3K cascade" EXACT [] is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction relationship: negatively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014068 name: positive regulation of phosphatidylinositol 3-kinase signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the phosphatidylinositol 3-kinase cascade." [GOC:ef] synonym: "activation of phosphoinositide 3-kinase cascade" NARROW [] synonym: "positive regulation of phosphatidylinositol 3-kinase cascade" RELATED [] synonym: "positive regulation of phosphoinositide 3-kinase cascade" EXACT [GOC:curators] synonym: "positive regulation of PI 3-kinase cascade" EXACT [] synonym: "positive regulation of PI3K cascade" EXACT [] synonym: "stimulation of phosphatidylinositol 3-kinase cascade" NARROW [] synonym: "up regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "up-regulation of phosphatidylinositol 3-kinase cascade" EXACT [] synonym: "upregulation of phosphatidylinositol 3-kinase cascade" EXACT [] is_a: GO:0014066 ! regulation of phosphatidylinositol 3-kinase signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction relationship: positively_regulates GO:0014065 ! phosphatidylinositol 3-kinase signaling [Term] id: GO:0014069 name: postsynaptic density namespace: cellular_component alt_id: GO:0097481 alt_id: GO:0097483 def: "An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components." [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] subset: goslim_synapse synonym: "neuronal postsynaptic density" EXACT [GO:0097481] synonym: "post synaptic density" EXACT [] synonym: "post-synaptic density" EXACT [] synonym: "postsynaptic density of dendrite" NARROW [] xref: NIF_Subcellular:sao1196688972 xref: Wikipedia:Postsynaptic_density is_a: GO:0097458 ! neuron part is_a: GO:0099572 ! postsynaptic specialization relationship: part_of GO:0032279 ! asymmetric synapse [Term] id: GO:0014070 name: response to organic cyclic compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus." [CHEBI:33832, GOC:ef] synonym: "response to organic cyclic substance" EXACT [GOC:mah] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0014071 name: response to cycloalkane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cycloalkane stimulus. A cycloalkane is a cyclic saturated hydrocarbon having the general formula CnH2n." [CHEBI:23453, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014072 name: response to isoquinoline alkaloid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an isoquinoline alkaloid stimulus. An isoquinoline alkaloid is any member of a group of compounds with the heterocyclic ring structure of benzo(c)pyridine which is a structure characteristic of the group of opium alkaloids." [CHEBI:24921, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014073 name: response to tropane namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tropane stimulus. Tropane is a nitrogenous bicyclic organic compound mainly known for a group of alkaloids derived from it (called tropane alkaloids), which include, among others, atropine and cocaine." [CHEBI:35615, GOC:ef] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0014074 name: response to purine-containing compound namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a purine-containing compound stimulus." [CHEBI:26401, GOC:ef] synonym: "response to purine" RELATED [GOC:curators] is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound [Term] id: GO:0014075 name: response to amine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups." [CHEBI:32952, GOC:ef] synonym: "response to amine stimulus" EXACT [GOC:dos] is_a: GO:0010243 ! response to organonitrogen compound [Term] id: GO:0014076 name: response to fluoxetine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fluoxetine stimulus. Fluoxetine increases the extracellular level of the neurotransmitter serotonin by inhibiting its reuptake into the presynaptic cell, increasing the level of serotonin available to bind to the postsynaptic receptor." [CHEBI:5118, GOC:ef, GOC:pr] comment: Note that this term is in the subset of terms that should not be used for direct manual annotation of gene products. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "response to selective serotonin reuptake inhibitor" RELATED [GOC:curators] synonym: "response to SSRI" RELATED [GOC:curators] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0036276 ! response to antidepressant [Term] id: GO:0014701 name: junctional sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium release channels, is devoted to calcium release and is juxtaposed to transverse tubule membrane. The junctional sarcoplasmic reticulum membrane consists of the junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014702 name: free sarcoplasmic reticulum membrane namespace: cellular_component def: "The part of the sarcoplasmic reticulum membrane that contains calcium pumps and is devoted to calcium uptake. The free sarcoplasmic reticulum membrane consists of the longitudinal sarcoplasmic reticulum membrane and the non-junctional region of the terminal cisterna membrane." [GOC:mtg_muscle] is_a: GO:0033017 ! sarcoplasmic reticulum membrane [Term] id: GO:0014703 name: oscillatory muscle contraction namespace: biological_process def: "A process in which force is generated within oscillatory skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Oscillatory muscle contraction occurs in insect wing muscles and is characterized by asynchrony between action potential and contraction and by stretch activation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014704 name: intercalated disc namespace: cellular_component def: "A complex cell-cell junction at which myofibrils terminate in cardiomyocytes; mediates mechanical and electrochemical integration between individual cardiomyocytes. The intercalated disc contains regions of tight mechanical attachment (fasciae adherentes and desmosomes) and electrical coupling (gap junctions) between adjacent cells." [GOC:mtg_muscle, PMID:11732910] synonym: "intercalated disk" EXACT [] xref: Wikipedia:Intercalated_disc is_a: GO:0044291 ! cell-cell contact zone [Term] id: GO:0014705 name: C zone namespace: cellular_component def: "A region of the A band in which myosin-binding protein C is located and that can be seen by electron microscopy. This is a functional zone that also includes myosin." [GOC:mtg_muscle] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0014706 name: striated muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a striated muscle over time, from its formation to the mature structure. Striated muscle contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle. Skeletal muscle myoblasts fuse to form myotubes and eventually multinucleated muscle fibers. The fusion of cardiac cells is very rare and can only form binucleate cells." [CL:0000737, GOC:dph, GOC:mtg_muscle] is_a: GO:0060537 ! muscle tissue development [Term] id: GO:0014707 name: branchiomeric skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure. The branchiomeric muscle is derived from cranial mesoderm and controls facial expression, pharyngeal and laryngeal function, operating the jaw. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. Branchiomeric muscles of mammals correspond to the gill musculature of fish." [GOC:mtg_muscle] is_a: GO:0007517 ! muscle organ development is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014708 name: regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitomeric trunk muscle development." [GOC:mtg_muscle] is_a: GO:0048634 ! regulation of muscle organ development relationship: regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014709 name: positive regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048636 ! positive regulation of muscle organ development relationship: positively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014710 name: negative regulation of somitomeric trunk muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of somitomeric trunk muscle development. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014708 ! regulation of somitomeric trunk muscle development is_a: GO:0048635 ! negative regulation of muscle organ development relationship: negatively_regulates GO:0002075 ! somitomeric trunk muscle development [Term] id: GO:0014711 name: regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014712 name: positive regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014713 name: negative regulation of branchiomeric skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of branchiomeric skeletal muscle development. Branchiomeric skeletal muscle development is the process whose specific outcome is the progression of the branchiomeric skeletal muscle over time, from its formation to the mature structure." [GOC:mtg_muscle] is_a: GO:0014711 ! regulation of branchiomeric skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0014707 ! branchiomeric skeletal muscle development [Term] id: GO:0014714 name: myoblast fate commitment in head namespace: biological_process def: "The process, taking place in the head, whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast fate commitment [Term] id: GO:0014715 name: myoblast fate commitment in trunk namespace: biological_process def: "The process taking place in the trunk whereby the developmental fate of a cell becomes restricted such that it will develop into a myoblast. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048625 ! myoblast fate commitment [Term] id: GO:0014716 name: skeletal muscle satellite stem cell asymmetric division involved in skeletal muscle regeneration namespace: biological_process def: "Skeletal muscle satellite cell asymmetric division that occurs during a process in which damaged muscle tissue is being rebuilt." [GOC:mtg_muscle] comment: Occurrence of this process outside of the context of muscle repair is probably very rare, so there is a good case for merging this with the parent class. synonym: "satellite cell asymmetric division involved in skeletal muscle regeneration" EXACT [] is_a: GO:0014833 ! skeletal muscle satellite stem cell asymmetric division relationship: part_of GO:0014834 ! skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration [Term] id: GO:0014717 name: regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell activation. The satellite cell activation is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0043416 ! regulation of skeletal muscle tissue regeneration is_a: GO:0050865 ! regulation of cell activation relationship: regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014718 name: positive regulation of satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of activation of satellite cell involved in skeletal muscle regeneration. The activation of satellite cell is the process that initiates satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate." [GOC:mtg_muscle] is_a: GO:0014717 ! regulation of satellite cell activation involved in skeletal muscle regeneration is_a: GO:0043415 ! positive regulation of skeletal muscle tissue regeneration is_a: GO:0050867 ! positive regulation of cell activation relationship: positively_regulates GO:0014901 ! satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014719 name: skeletal muscle satellite cell activation namespace: biological_process def: "The change of a skeletal muscle satellite cell from a mitotically quiescent to a mitotically active state following exposure to some activating factor such as a cellular or soluble ligand. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle, PMID:23303905] is_a: GO:0001775 ! cell activation [Term] id: GO:0014720 name: tonic skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within tonic skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The tonic skeletal muscle is characterized by long lasting contractile responses and high resistance to fatigue." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014721 name: twitch skeletal muscle contraction namespace: biological_process def: "A process in which force is generated within twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The twitch skeletal muscle responds to neurostimulations with a contraction followed by a relaxation." [GOC:mtg_muscle] is_a: GO:0003010 ! voluntary skeletal muscle contraction [Term] id: GO:0014722 name: regulation of skeletal muscle contraction by calcium ion signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing the calcium ion signals that trigger contraction." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction by calcium ion signalling" EXACT [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0019722 ! calcium-mediated signaling [Term] id: GO:0014723 name: regulation of skeletal muscle contraction by modulation of calcium ion sensitivity of myofibril namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by changing calcium ion binding affinity of the myofibril." [GOC:mtg_muscle] synonym: "regulation of calcium ion sensitivity of myofibril involved in skeletal muscle contraction" EXACT [] is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014724 name: regulation of twitch skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of twitch skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction relationship: regulates GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0014725 name: regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0048641 ! regulation of skeletal muscle tissue development relationship: regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014726 name: negative regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048642 ! negative regulation of skeletal muscle tissue development relationship: negatively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014727 name: positive regulation of extraocular skeletal muscle development namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of extraocular skeletal muscle development. Extraocular skeletal muscle development is the process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle." [GOC:mtg_muscle] is_a: GO:0014725 ! regulation of extraocular skeletal muscle development is_a: GO:0048643 ! positive regulation of skeletal muscle tissue development relationship: positively_regulates GO:0002074 ! extraocular skeletal muscle development [Term] id: GO:0014728 name: regulation of the force of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the force of skeletal muscle contraction. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through the formation of cross bridges." [GOC:mtg_muscle] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion [Term] id: GO:0014729 name: regulation of the velocity of shortening of skeletal muscle modulating contraction namespace: biological_process def: "Any process that modulates velocity of shortening of a skeletal muscle contraction. The shortening leads to reduction of the length of muscle fibers and sarcomeres." [GOC:mtg_muscle] synonym: "regulation of the velocity of shortening of skeletal muscle during contraction" RELATED [GOC:dph] is_a: GO:0014862 ! regulation of skeletal muscle contraction by chemo-mechanical energy conversion is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014730 name: skeletal muscle regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of muscle tissue to repair injured or damaged muscle fibers in the postnatal stage at the neuromuscular junction. Regeneration of neuromuscular junctions occurs in an orderly way and relies on communication between nerve and muscle. Skeletal myofibers regenerate after injury and form neuro-muscular junctions with motor axons similar to normal ones. Regenerating myofibers develop within the basal lamina sheaths (satellite cells) of original myofibers." [GOC:mtg_muscle] is_a: GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014731 name: spectrin-associated cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton composed of spectrin, protein 4.1 and ankyrin. Spectrin-associated cytoskeleton is associated with the plasma membrane." [GOC:mtg_muscle, PMID:15970557] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0014732 name: skeletal muscle atrophy namespace: biological_process def: "A process, occurring in skeletal muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014891 ! striated muscle atrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014733 name: regulation of skeletal muscle adaptation namespace: biological_process def: "Any process in which skeletal muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "regulation of skeletal muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014734 name: skeletal muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size (not length) of individual muscle fibers without cell division. In the case of skeletal muscle cells this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014897 ! striated muscle hypertrophy is_a: GO:0043501 ! skeletal muscle adaptation [Term] id: GO:0014735 name: regulation of muscle atrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014736 name: negative regulation of muscle atrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014737 name: positive regulation of muscle atrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle atrophy." [GOC:mtg_muscle] is_a: GO:0014735 ! regulation of muscle atrophy is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014889 ! muscle atrophy [Term] id: GO:0014738 name: regulation of muscle hyperplasia namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0043502 ! regulation of muscle adaptation relationship: regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014739 name: positive regulation of muscle hyperplasia namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014744 ! positive regulation of muscle adaptation relationship: positively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014740 name: negative regulation of muscle hyperplasia namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hyperplasia." [GOC:mtg_muscle] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0014745 ! negative regulation of muscle adaptation relationship: negatively_regulates GO:0014900 ! muscle hyperplasia [Term] id: GO:0014741 name: negative regulation of muscle hypertrophy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014742 name: positive regulation of muscle hypertrophy namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014743 name: regulation of muscle hypertrophy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle hypertrophy." [GOC:mtg_muscle] is_a: GO:0090257 ! regulation of muscle system process relationship: regulates GO:0014896 ! muscle hypertrophy [Term] id: GO:0014744 name: positive regulation of muscle adaptation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "positive regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048584 ! positive regulation of response to stimulus is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014745 name: negative regulation of muscle adaptation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of muscle adaptation." [GOC:mtg_muscle] synonym: "negative regulation of muscle plasticity" RELATED [] is_a: GO:0043502 ! regulation of muscle adaptation is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0043500 ! muscle adaptation [Term] id: GO:0014746 name: regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction relationship: regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014747 name: positive regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014748 name: negative regulation of tonic skeletal muscle contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of tonic skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014746 ! regulation of tonic skeletal muscle contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0014720 ! tonic skeletal muscle contraction [Term] id: GO:0014801 name: longitudinal sarcoplasmic reticulum namespace: cellular_component def: "The portion of the free sarcoplasmic reticulum consisting of longitudinal tubules that connect terminal cisternae." [GOC:mtg_muscle] is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014802 name: terminal cisterna namespace: cellular_component def: "The portion of sarcoplasmic reticulum devoted to calcium ion storage and calcium ion release." [GOC:mtg_muscle] xref: Wikipedia:Terminal_cisterna is_a: GO:0098827 ! endoplasmic reticulum subcompartment relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0014803 name: longitudinal sarcoplasmic reticulum lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the longitudinal sarcoplasmic reticulum envelope. The longitudinal sarcoplasmic reticulum lumen is continuous with the lumen contained within the terminal cisternae." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen relationship: part_of GO:0014801 ! longitudinal sarcoplasmic reticulum [Term] id: GO:0014804 name: terminal cisterna lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the terminal cisterna envelope. This space is enriched in calsequestrin." [GOC:mtg_muscle] is_a: GO:0033018 ! sarcoplasmic reticulum lumen relationship: part_of GO:0014802 ! terminal cisterna [Term] id: GO:0014805 name: smooth muscle adaptation namespace: biological_process def: "Any process in which smooth muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "smooth muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014806 name: smooth muscle hyperplasia namespace: biological_process def: "A process, occurring in smooth muscle, in which there is an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014900 ! muscle hyperplasia [Term] id: GO:0014807 name: regulation of somitogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of somitogenesis." [GOC:mtg_muscle] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development relationship: regulates GO:0001756 ! somitogenesis [Term] id: GO:0014808 name: release of sequestered calcium ion into cytosol by sarcoplasmic reticulum namespace: biological_process def: "The process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels." [GOC:mtg_muscle] synonym: "release of sequestered calcium ion by sarcoplasmic reticulum into cytosol" RELATED [GOC:dph, GOC:tb] is_a: GO:0070296 ! sarcoplasmic reticulum calcium ion transport is_a: GO:1903514 ! release of sequestered calcium ion into cytosol by endoplasmic reticulum [Term] id: GO:0014809 name: regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0010880 ! regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum is_a: GO:0014722 ! regulation of skeletal muscle contraction by calcium ion signaling [Term] id: GO:0014810 name: positive regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045989 ! positive regulation of striated muscle contraction [Term] id: GO:0014811 name: negative regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle contraction via the regulation of the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol. The sarcoplasmic reticulum is the endoplasmic reticulum of striated muscle, specialised for the sequestration of calcium ions that are released upon receipt of a signal relayed by the T tubules from the neuromuscular junction." [GOC:mtg_muscle] is_a: GO:0014809 ! regulation of skeletal muscle contraction by regulation of release of sequestered calcium ion is_a: GO:0045988 ! negative regulation of striated muscle contraction [Term] id: GO:0014812 name: muscle cell migration namespace: biological_process def: "The orderly movement of a muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000187, GOC:mtg_muscle] is_a: GO:0016477 ! cell migration [Term] id: GO:0014813 name: skeletal muscle satellite cell commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0014816 ! skeletal muscle satellite cell differentiation [Term] id: GO:0014814 name: axon regeneration at neuromuscular junction namespace: biological_process def: "The regrowth of axons following their loss or damage at the neuromuscular junction. Motor axons regenerate after injury and they form neuro-muscular junctions with skeletal myofibers similar to normal ones." [GOC:ef, GOC:mtg_muscle] is_a: GO:0031103 ! axon regeneration [Term] id: GO:0014815 name: initiation of skeletal muscle satellite cell activation by growth factor signaling, involved in skeletal muscle regeneration namespace: biological_process def: "Signalling between growth factors and their receptors that results in the activation of satellite cell, where this process is involved in skeletal muscle regeneration. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014718 ! positive regulation of satellite cell activation involved in skeletal muscle regeneration [Term] id: GO:0014816 name: skeletal muscle satellite cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a satellite cell." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0035914 ! skeletal muscle cell differentiation [Term] id: GO:0014817 name: skeletal muscle satellite cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment [Term] id: GO:0014818 name: skeletal muscle satellite cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a skeletal muscle satellite cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048867 ! stem cell fate determination relationship: part_of GO:0014813 ! skeletal muscle satellite cell commitment [Term] id: GO:0014819 name: regulation of skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction." [GOC:ef, GOC:mtg_muscle] is_a: GO:0006942 ! regulation of striated muscle contraction relationship: regulates GO:0003009 ! skeletal muscle contraction [Term] id: GO:0014820 name: tonic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within tonic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the tonic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Tonic smooth muscle contraction occurs as a sustained continuous contraction." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014821 name: phasic smooth muscle contraction namespace: biological_process def: "A process in which force is generated within phasic smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the phasic smooth muscle, the muscle contraction occurs without an ordered sarcomeric structure. Phasic smooth muscle contraction occurs in a series of discrete contractions and relaxations." [GOC:mtg_muscle] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014822 name: detection of wounding namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal." [GOC:mtg_muscle] synonym: "detection of injury" EXACT [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009611 ! response to wounding [Term] id: GO:0014823 name: response to activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an activity stimulus." [GOC:mtg_muscle] synonym: "response to exercise" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014824 name: artery smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the artery. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The artery is a vessel carrying blood away from the heart." [GOC:mtg_muscle, MA:0000708, MSH:D001158] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014825 name: stomach fundus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the fundus of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fundus is the portion of the stomach that lies above the cardiac notch." [GOC:mtg_muscle, MA:0001612] is_a: GO:0014847 ! proximal stomach smooth muscle contraction [Term] id: GO:0014826 name: vein smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the vein. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The vein is a vessel carrying blood away from the capillary beds." [GOC:mtg_muscle, MA:0000715, MSH:D014680] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0014827 name: intestine smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the intestine. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The intestine is the section of the alimentary canal from the stomach to the anal canal. It includes the large intestine and small intestine." [GOC:mtg_muscle, MA:0001539, MSH:D007422] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014828 name: distal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the distal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The distal stomach is composed of the lower body and antrum and develops strong peristaltic phasic contractions that increase in amplitude as they propagate toward the pylorus." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0120063 ! stomach smooth muscle contraction [Term] id: GO:0014829 name: vascular smooth muscle contraction namespace: biological_process def: "A process, occurring in the vascular tissue, whereby actin/myosin complex activity generates force through ATP hydrolysis resulting in a change in smooth muscle geometry. This process is always coupled to chemo-mechanical energy conversion." [GOC:mtg_muscle, MA:0002718] is_a: GO:0006939 ! smooth muscle contraction is_a: GO:0042310 ! vasoconstriction [Term] id: GO:0014830 name: arteriole smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the arteriole. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The arteriole is the smallest division of the artery located between the muscular arteries and the capillaries." [GOC:mtg_muscle, MA:0000706, MSH:D001160] is_a: GO:0014824 ! artery smooth muscle contraction [Term] id: GO:0014831 name: gastro-intestinal system smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the gastro-intestinal system. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The gastro-intestinal system generally refers to the digestive structures stretching from the mouth to anus, but does not include the accessory glandular organs (liver, pancreas and biliary tract)." [GOC:mtg_muscle, MA:0001523, MSH:D041981] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014832 name: urinary bladder smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary bladder. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary bladder is a musculomembranous sac along the urinary tract." [GOC:mr, GOC:mtg_muscle, http://en.wikipedia.org/wiki/Rhea_(bird), MA:0001697, MSH:D001743, PMID:11768524, PMID:18276178, PMID:538956] is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014833 name: skeletal muscle satellite stem cell asymmetric division namespace: biological_process def: "The asymmetric division of a skeletal muscle satellite stem cell to produce two daughter cells, one of which is destined to differentiate and the other to be a quiescent cell that restocks the satellite cell pool." [GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "satellite cell asymmetric division" EXACT [] is_a: GO:0098722 ! asymmetric stem cell division relationship: part_of GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0014834 name: skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration namespace: biological_process def: "Any process by which the number of skeletal muscle satellite cells in a skeletal muscle is maintained during muscle regeneration. There are at least three mechanisms by which this is achieved. Skeletal muscle satellite stem cell asymmetric division ensures satellite stem cell numbers are kept constant. Symmetric division of these cells amplifies the number of skeletal muscle satellite stem cells. Some adult skeletal muscle myoblasts (descendants of activated satellite cells) can develop back into quiescent satellite cells, replenishing the overall pool of satellite cells." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb, PMID:23303905] synonym: "satellite cell compartment self-renewal involved in skeletal muscle regeneration" EXACT [GOC:dph, GOC:tb] synonym: "satellite cell population maintenance" EXACT [] synonym: "satellite cell self-renewal" BROAD [] is_a: GO:0098727 ! maintenance of cell number relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014835 name: myoblast differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized satellite cell acquires specialized features of a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0045445 ! myoblast differentiation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014836 name: myoblast fate commitment involved in skeletal muscle regeneration namespace: biological_process def: "The process in which the developmental fate of a satellite cell becomes restricted such that it will develop into a myoblast. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048625 ! myoblast fate commitment relationship: part_of GO:0014835 ! myoblast differentiation involved in skeletal muscle regeneration [Term] id: GO:0014837 name: myoblast fate determination involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast regardless of its environment; upon determination, the cell fate cannot be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0007518 ! myoblast fate determination relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014838 name: myoblast fate specification involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a satellite cell becomes capable of differentiating autonomously into a myoblast in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0048626 ! myoblast fate specification relationship: part_of GO:0014836 ! myoblast fate commitment involved in skeletal muscle regeneration [Term] id: GO:0014839 name: myoblast migration involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a myoblast migrates along an entire fiber to the site of injury. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] synonym: "mononucleate cell migration involved in skeletal muscle regeneration" BROAD [] is_a: GO:0051451 ! myoblast migration relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014841 name: skeletal muscle satellite cell proliferation namespace: biological_process def: "The multiplication or reproduction of satellite cells, resulting in the expansion of the cell population. Satellite cells are quiescent cells that are located between the basal lamina and the plasmalemma of the muscle fiber, which are the main contributors to postnatal muscle growth. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014842 name: regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle satellite cell proliferation." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation relationship: regulates GO:0014841 ! skeletal muscle satellite cell proliferation [Term] id: GO:0014843 name: growth factor dependent regulation of skeletal muscle satellite cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of satellite cell proliferation; dependent on specific growth factor activity such as fibroblast growth factors and transforming growth factor beta." [GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0014842 ! regulation of skeletal muscle satellite cell proliferation [Term] id: GO:0014844 name: myoblast proliferation involved in skeletal muscle regeneration namespace: biological_process def: "The multiplication or reproduction of myoblasts, resulting in the expansion of the cell population. This occurs as part of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle, PMID:16607119] is_a: GO:0051450 ! myoblast proliferation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014845 name: stomach body smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the body of stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The body of stomach is the part of the stomach that lies between the fundus above and the pyloric antrum below; its boundaries are poorly defined." [GOC:ef, GOC:mtg_muscle, MA:0002559] is_a: GO:0014828 ! distal stomach smooth muscle contraction [Term] id: GO:0014846 name: esophagus smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the esophagus. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The esophagus is the muscular membranous segment between the pharynx and the stomach in the upper gastrointestinal tract." [GOC:ef, GOC:mtg_muscle, MA:0001573, MSH:D041742] synonym: "oesophagus smooth muscle contraction" RELATED [GOC:dph] is_a: GO:0014831 ! gastro-intestinal system smooth muscle contraction [Term] id: GO:0014847 name: proximal stomach smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the proximal stomach. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The proximal stomach, composed of the fundus and upper body, shows low frequency, sustained tonic contractions that are responsible for generating a basal pressure within the stomach." [GOC:mtg_muscle, http://biology.about.com] is_a: GO:0014820 ! tonic smooth muscle contraction is_a: GO:0120063 ! stomach smooth muscle contraction [Term] id: GO:0014848 name: urinary tract smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the urinary tract. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The urinary tract consists of organs of the body that produce and discharge urine. These include the kidneys, ureters, bladder, and urethra." [GOC:ef, GOC:mtg_muscle, MA:0000325, MSH:D014551] is_a: GO:0006939 ! smooth muscle contraction [Term] id: GO:0014849 name: ureter smooth muscle contraction namespace: biological_process def: "A process in which force is generated within smooth muscle tissue, resulting in a change in muscle geometry. This process occurs in the ureter. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The ureter is one of a pair of thick-walled tubes that transports urine from the kidney pelvis to the urinary bladder." [GOC:mtg_muscle, MA:0000378] is_a: GO:0014821 ! phasic smooth muscle contraction is_a: GO:0014848 ! urinary tract smooth muscle contraction [Term] id: GO:0014850 name: response to muscle activity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity [Term] id: GO:0014852 name: regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by variation of the pattern of stimulation by nervous system." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014853 name: regulation of excitatory postsynaptic membrane potential involved in skeletal muscle contraction namespace: biological_process def: "Any process, involved in skeletal muscle contraction, that modulates the establishment or extent of the excitatory postsynaptic potential (EPSP). Excitatory postsynaptic potential (EPSP) is a temporay increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential." [GOC:ef, GOC:mtg_muscle] synonym: "regulation of excitatory post-synaptic membrane potential involved in skeletal muscle contraction" EXACT [] is_a: GO:0098815 ! modulation of excitatory postsynaptic potential relationship: part_of GO:0003009 ! skeletal muscle contraction relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014854 name: response to inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0014855 name: striated muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of striated muscle cells, resulting in the expansion of a cell population. Striated muscles contain fibers that are divided by transverse bands into striations, and cardiac and skeletal muscle are types of striated muscle." [CL:0000737, GOC:ef, GOC:mtg_muscle] is_a: GO:0033002 ! muscle cell proliferation [Term] id: GO:0014856 name: skeletal muscle cell proliferation namespace: biological_process def: "The multiplication or reproduction of skeletal muscle cells, resulting in the expansion of a cell population." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0014855 ! striated muscle cell proliferation [Term] id: GO:0014857 name: regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0042127 ! regulation of cell population proliferation relationship: regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014858 name: positive regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008284 ! positive regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation relationship: positively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014859 name: negative regulation of skeletal muscle cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of skeletal muscle cell proliferation." [CL:0000188, GOC:ef, GOC:mtg_muscle] is_a: GO:0008285 ! negative regulation of cell population proliferation is_a: GO:0014857 ! regulation of skeletal muscle cell proliferation relationship: negatively_regulates GO:0014856 ! skeletal muscle cell proliferation [Term] id: GO:0014860 name: neurotransmitter secretion involved in regulation of skeletal muscle contraction namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft involved in skeletal muscle contraction. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, GOC:mtg_muscle, GOC:tb] synonym: "neurotransmitter secretion involved in control of skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0007269 ! neurotransmitter secretion relationship: part_of GO:0014852 ! regulation of skeletal muscle contraction by neural stimulation via neuromuscular junction [Term] id: GO:0014861 name: regulation of skeletal muscle contraction via regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by depolarization of muscle membrane and ionic fluxes." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] synonym: "regulation of skeletal muscle contraction via membrane action potential" RELATED [] is_a: GO:0014819 ! regulation of skeletal muscle contraction is_a: GO:0098900 ! regulation of action potential relationship: regulates GO:0100001 ! regulation of skeletal muscle contraction by action potential [Term] id: GO:0014862 name: regulation of skeletal muscle contraction by chemo-mechanical energy conversion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of skeletal muscle contraction by regulating force and velocity of shortening. The force of skeletal muscle contraction is produced by acto-myosin interaction processes through formation of cross bridges. The shortening leads to reduction of length of muscle fiber and sarcomeres." [GOC:mtg_muscle] is_a: GO:0014819 ! regulation of skeletal muscle contraction [Term] id: GO:0014863 name: detection of inactivity namespace: biological_process def: "The series of events in which a inactivity stimulus is received by a cell or organism and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014864 name: detection of muscle activity namespace: biological_process def: "The series of events in which a muscle activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014865 ! detection of activity [Term] id: GO:0014865 name: detection of activity namespace: biological_process def: "The series of events in which an activity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014823 ! response to activity is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0014866 name: skeletal myofibril assembly namespace: biological_process def: "The process whose specific outcome is the progression of the skeletal myofibril over time, from its formation to the mature structure. A skeletal myofibril is a myofibril specific to skeletal muscle cells." [GOC:ef, GOC:mtg_muscle] is_a: GO:0030239 ! myofibril assembly [Term] id: GO:0014868 name: cross bridge cycling involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "A process in which cross bridges are broken and reformed during filament sliding as part of the regulation of the velocity of shortening in skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014869 name: detection of muscle inactivity namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_muscle] is_a: GO:0014863 ! detection of inactivity is_a: GO:0014870 ! response to muscle inactivity [Term] id: GO:0014870 name: response to muscle inactivity namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus." [GOC:mtg_muscle] is_a: GO:0014854 ! response to inactivity [Term] id: GO:0014871 name: cross bridge formation involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "The process in which actin and myosin interact, split ATP and generate force during skeletal muscle contraction. This process is one of the components of the regulation of the force of skeletal muscle contraction." [GOC:mtg_muscle] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction [Term] id: GO:0014872 name: myoblast division namespace: biological_process def: "The process resulting in the physical partitioning and separation of a myoblast into daughter cells. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:ef, GOC:mtg_muscle] is_a: GO:0051301 ! cell division [Term] id: GO:0014873 name: response to muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle activity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to fatigue" EXACT [] synonym: "response to muscle activity involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014850 ! response to muscle activity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014874 name: response to stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0050896 ! response to stimulus relationship: part_of GO:0043502 ! regulation of muscle adaptation [Term] id: GO:0014875 name: detection of muscle activity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which a muscle activity stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of fatigue" EXACT [] is_a: GO:0014864 ! detection of muscle activity is_a: GO:0014873 ! response to muscle activity involved in regulation of muscle adaptation [Term] id: GO:0014876 name: response to injury involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a injury. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0009611 ! response to wounding is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014877 name: response to muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muscle inactivity stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014870 ! response to muscle inactivity is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation [Term] id: GO:0014878 name: response to electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "response to electrical stimulus involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014874 ! response to stimulus involved in regulation of muscle adaptation is_a: GO:0051602 ! response to electrical stimulus [Term] id: GO:0014879 name: detection of electrical stimulus involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an electrical stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014878 ! response to electrical stimulus involved in regulation of muscle adaptation is_a: GO:0050981 ! detection of electrical stimulus [Term] id: GO:0014880 name: regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding relationship: part_of GO:0014729 ! regulation of the velocity of shortening of skeletal muscle modulating contraction [Term] id: GO:0014881 name: regulation of myofibril size namespace: biological_process def: "Any process that modulates the size of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril size" EXACT [] is_a: GO:0014743 ! regulation of muscle hypertrophy is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0014882 name: regulation of myofibril number namespace: biological_process def: "Any process that modulates the number of myofibrils. A myofibril is the contractile element of skeletal and cardiac muscle. It is a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [GOC:dph, GOC:ef, GOC:mtg_muscle, GOC:tb] synonym: "change of myofibril number" EXACT [] is_a: GO:0014738 ! regulation of muscle hyperplasia is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0014883 name: transition between fast and slow fiber namespace: biological_process def: "The process of conversion of fast-contracting muscle fibers to a slower character. This may involve slowing of contractile rate, slow myosin gene induction, increase in oxidative metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between fast and slow fibre" EXACT [] synonym: "transition fast-slow fiber" EXACT [] synonym: "transition fast-slow fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014884 name: detection of muscle inactivity involved in regulation of muscle adaptation namespace: biological_process def: "The series of events in which a muscle inactivity stimulus is received by a cell and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] is_a: GO:0014869 ! detection of muscle inactivity is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014885 name: detection of injury involved in regulation of muscle adaptation namespace: biological_process def: "The series of events by which an injury stimulus is received and converted into a molecular signal. This occurs as part of the regulation of muscle adaptation." [GOC:ef, GOC:mtg_muscle] synonym: "detection of injury involved in regulation of muscle plasticity" RELATED [] is_a: GO:0014822 ! detection of wounding is_a: GO:0014876 ! response to injury involved in regulation of muscle adaptation [Term] id: GO:0014886 name: transition between slow and fast fiber namespace: biological_process def: "The process of conversion of slow-contracting muscle fibers to a faster character. This may involve increasing of contractile rate, fast myosin gene induction, increase in glycolytic metabolic properties, altered electrophysiology and altered innervation. This process also regulates skeletal muscle adapatation." [GOC:ef, GOC:mtg_muscle] synonym: "transition between slow and fast fibre" EXACT [] synonym: "transition slow-fast fiber" EXACT [] synonym: "transition slow-fast fibre" EXACT [] is_a: GO:0014733 ! regulation of skeletal muscle adaptation [Term] id: GO:0014887 name: cardiac muscle adaptation namespace: biological_process def: "The process in which cardiac muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors." [GOC:mtg_muscle] synonym: "cardiac muscle plasticity" RELATED [] is_a: GO:0014888 ! striated muscle adaptation [Term] id: GO:0014888 name: striated muscle adaptation namespace: biological_process def: "Any process in which striated muscle adapts, with consequent modifications to structural and/or functional phenotypes, in response to a stimulus. Stimuli include contractile activity, loading conditions, substrate supply, and environmental factors. These adaptive events occur in both muscle fibers and associated structures (motoneurons and capillaries), and they involve alterations in regulatory mechanisms, contractile properties and metabolic capacities." [GOC:mtg_muscle] synonym: "striated muscle plasticity" RELATED [] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014889 name: muscle atrophy namespace: biological_process def: "A process, occurring in the muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] comment: GO:0014889 should only be used for annotation when muscle atrophy is a normal physiological process and not a disease process. xref: Wikipedia:Muscle_atrophy is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014890 name: smooth muscle atrophy namespace: biological_process def: "A process, occurring in smooth muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014891 name: striated muscle atrophy namespace: biological_process def: "A process, occurring in striated muscle, that is characterized by a decrease in protein content, fiber diameter, force production and fatigue resistance in response to different conditions such as starvation, aging and disuse." [GOC:mtg_muscle] is_a: GO:0014888 ! striated muscle adaptation is_a: GO:0014889 ! muscle atrophy [Term] id: GO:0014893 name: response to rest involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rest stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014894 name: response to denervation involved in regulation of muscle adaptation namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a denervation stimulus. This process occurs as part of the regulation of muscle adaptation." [GOC:mtg_muscle] is_a: GO:0014877 ! response to muscle inactivity involved in regulation of muscle adaptation [Term] id: GO:0014895 name: smooth muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of its smooth muscle cells without cell division. Physiological hypertrophy is a normal process during development, and can also occur in mature structures on demand. In the uterus, smooth muscle cells undergo hypertrophy during pregnancy." [GOC:mtg_muscle] is_a: GO:0014805 ! smooth muscle adaptation is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014896 name: muscle hypertrophy namespace: biological_process def: "The muscle system process that results in enlargement or overgrowth of all or part of a muscle organ due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development (it stops in cardiac muscle after adolescence) and can also be brought on in response to demand. In athletes cardiac and skeletal muscles undergo hypertrophy stimulated by increasing muscle activity on exercise. Smooth muscle cells in the uterus undergo hypertrophy during pregnancy." [GOC:mtg_muscle] xref: Wikipedia:Muscle_hypertrophy is_a: GO:0003012 ! muscle system process [Term] id: GO:0014897 name: striated muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of an organ due to an increase in size of muscle cells without cell division. In the case of striated muscle, this happens due to the additional synthesis of sarcomeric proteins and assembly of myofibrils." [GOC:mtg_muscle] is_a: GO:0014896 ! muscle hypertrophy [Term] id: GO:0014898 name: cardiac muscle hypertrophy in response to stress namespace: biological_process def: "The physiological enlargement or overgrowth of all or part of the heart muscle due to an increase in size (not length) of individual cardiac muscle fibers, without cell division, as a result of a disturbance in organismal or cellular homeostasis." [GOC:BHF, GOC:mtg_cardiac_conduct_nov11, GOC:mtg_muscle] is_a: GO:0003299 ! muscle hypertrophy in response to stress is_a: GO:0003300 ! cardiac muscle hypertrophy is_a: GO:0014887 ! cardiac muscle adaptation [Term] id: GO:0014899 name: cardiac muscle atrophy namespace: biological_process def: "A process, occurring in the heart, in which a decrease in cell mass and then in heart size occurs due to shrinking of the individual cells. The shrinkage is caused by protein degradation." [GOC:mtg_muscle] is_a: GO:0014887 ! cardiac muscle adaptation is_a: GO:0014891 ! striated muscle atrophy [Term] id: GO:0014900 name: muscle hyperplasia namespace: biological_process def: "A muscle system process that results in an increase in cell number by cell division, often leading to an increase in the size of an organ." [GOC:mtg_muscle] is_a: GO:0043500 ! muscle adaptation [Term] id: GO:0014901 name: satellite cell activation involved in skeletal muscle regeneration namespace: biological_process def: "The process that initiates skeletal muscle satellite cell division by causing it to move from quiescence to the G1 stage of the cell cycle. The cell swells and there are a number of other small changes. The cells then start to divide. Following cell division the cells will differentiate. In adult muscle, satellite cells become activated to divide and differentiate in response to muscle damage." [GOC:mtg_muscle] is_a: GO:0014719 ! skeletal muscle satellite cell activation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014902 name: myotube differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0051146 ! striated muscle cell differentiation [Term] id: GO:0014904 name: myotube cell development namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0055002 ! striated muscle cell development relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0014905 name: myoblast fusion involved in skeletal muscle regeneration namespace: biological_process def: "A process in which non-proliferating myoblasts, after migrating to the site of injury, fuse into existing damaged fibers or fuse to myotubes to form new fibers, as part of the process of skeletal muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0007520 ! myoblast fusion relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014906 name: myotube cell development involved in skeletal muscle regeneration namespace: biological_process def: "The process aimed at the progression of a myotube cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. This occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014904 ! myotube cell development relationship: part_of GO:0014908 ! myotube differentiation involved in skeletal muscle regeneration [Term] id: GO:0014908 name: myotube differentiation involved in skeletal muscle regeneration namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a myotube cell. Myotube differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual myotubes can fuse to form bigger myotubes and start to contract. This process occurs as part of the process of skeletal muscle regeneration. Myotubes are multinucleated cells that are formed when proliferating myoblasts exit the cell cycle, differentiate and fuse." [GOC:mtg_muscle] is_a: GO:0014902 ! myotube differentiation relationship: part_of GO:0043403 ! skeletal muscle tissue regeneration [Term] id: GO:0014909 name: smooth muscle cell migration namespace: biological_process def: "The orderly movement of a smooth muscle cell from one site to another, often during the development of a multicellular organism." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014812 ! muscle cell migration [Term] id: GO:0014910 name: regulation of smooth muscle cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0030334 ! regulation of cell migration relationship: regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014911 name: positive regulation of smooth muscle cell migration namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030335 ! positive regulation of cell migration relationship: positively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014912 name: negative regulation of smooth muscle cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smooth muscle cell migration." [CL:0000192, GOC:mtg_muscle] is_a: GO:0014910 ! regulation of smooth muscle cell migration is_a: GO:0030336 ! negative regulation of cell migration relationship: negatively_regulates GO:0014909 ! smooth muscle cell migration [Term] id: GO:0014914 name: myoblast maturation involved in muscle regeneration namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a myoblast cell to attain its fully functional state involved in muscle regeneration. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle] is_a: GO:0048628 ! myoblast maturation [Term] id: GO:0014915 name: regulation of muscle filament sliding speed involved in regulation of the velocity of shortening in skeletal muscle contraction namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding, and consequently contributes to the regulation of the velocity of shortening of skeletal muscle contraction." [GOC:dph, GOC:mtg_muscle, GOC:tb] is_a: GO:0014880 ! regulation of muscle filament sliding involved in regulation of the velocity of shortening in skeletal muscle contraction is_a: GO:0032972 ! regulation of muscle filament sliding speed [Term] id: GO:0014916 name: regulation of lung blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the lungs. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] synonym: "regulation of pulmonary blood pressure" EXACT [] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0014917 name: obsolete positive regulation of diuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases the rate of diuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of diuresis by pressure natriuresis" EXACT [] is_obsolete: true replaced_by: GO:0035818 [Term] id: GO:0014918 name: obsolete positive regulation of natriuresis by pressure natriuresis namespace: biological_process def: "OBSOLETE. The process in which pressure natriuresis increases rate of natriuresis." [GOC:mtg_cardio] comment: This term was made obsolete because its definition was inaccurate. synonym: "positive regulation of natriuresis by pressure natriuresis" EXACT [] is_obsolete: true replaced_by: GO:0035819 [Term] id: GO:0015000 name: obsolete polyferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. synonym: "polyferredoxin" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015001 name: obsolete high-potential iron-sulfur carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "high-potential iron-sulfur carrier" EXACT [] synonym: "high-potential iron-sulphur carrier" EXACT [] synonym: "HiPIP" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015002 name: heme-copper terminal oxidase activity namespace: molecular_function def: "Catalysis of the four-electron reduction of dioxygen (O2) to water, coupled to generation of a proton electrochemical gradient across a membrane." [GOC:kd] synonym: "haem-copper terminal oxidase activity" EXACT [] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015003 name: obsolete copper electron carrier namespace: molecular_function def: "OBSOLETE. A copper-containing entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "copper electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015004 name: obsolete small blue copper electron carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "small blue copper electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015005 name: obsolete azurin namespace: molecular_function def: "OBSOLETE. Brilliant blue copper-containing protein of low molecular weight found in some bacteria; thought to transfer electrons to cytochrome oxidase. This definition includes pseudoazurin." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "azurin" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0015006 name: obsolete plastocyanin namespace: molecular_function def: "OBSOLETE. A copper-containing electron carrier acting between cytochrome b(6)-f and P700 of photosystem I." [ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. synonym: "plastocyanin" EXACT [] is_obsolete: true replaced_by: GO:0046028 [Term] id: GO:0015007 name: obsolete electron carrier, chlorophyll electron transport system namespace: molecular_function def: "OBSOLETE. A molecular entity that serves as an electron acceptor and electron donor in a chlorophyll electron transport system." [ISBN:0198506732] comment: This term was made obsolete because it contains both process and function information. synonym: "chlorophyll electron carrier" RELATED [] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] is_obsolete: true consider: GO:0009055 consider: GO:0009767 [Term] id: GO:0015009 name: corrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving corrin, C19H22N4, the fundamental heterocyclic skeleton of the corrinoids. It consists of four reduced pyrrole rings joined into a macrocyclic ring. Corrin is the core of the vitamin B12 molecule." [GOC:ai, ISBN:0198506732] synonym: "corrin metabolism" EXACT [] is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0015010 name: tetrahydrocorphin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrocorphins, tetrapyrroles that combine the structural elements of both porphyrins and corrins." [http://findarticles.com/p/articles/mi_m0841/is_n1_v28/ai_13746418, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44] synonym: "tetrahydrocorphin metabolism" EXACT [] is_a: GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process [Term] id: GO:0015011 name: nickel-tetrapyrrole coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an enzyme cofactor consisting of a tetrapyrrole structure containing nickel, such as the F-430 cofactor found in methyl-coenzyme M reductase." [GOC:mah, http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#44, http://www.chem.qmul.ac.uk/iupac/bioinorg/EG.html#33] synonym: "coenzyme F430 metabolic process" NARROW [] synonym: "nickel-tetrapyrrole coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process [Term] id: GO:0015012 name: heparan sulfate proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the heparan sulfate proteoglycan, a glycosaminoglycan with repeat unit consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues; the former are a mixture of sulfated and nonsulfated D-glucuronic acid and L-iduronic acid; the L-iduronic acid is either sulfated or acetylated on its amino group as well as being sulfated on one of its hydroxyl groups; heparan sulfate chains are covalently linked to peptidyl-serine by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylosyl to serine residues." [GOC:mah, ISBN:0198506732, ISBN:0198547684, RESID:AA0210] synonym: "heparan sulfate proteoglycan anabolism" EXACT [] synonym: "heparan sulfate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process" RELATED [] xref: RESID:AA0210 is_a: GO:0030166 ! proteoglycan biosynthetic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process [Term] id: GO:0015013 name: heparan sulfate proteoglycan biosynthetic process, linkage to polypeptide namespace: biological_process def: "The polymerization of one or more heparan sulfate chains via a xylose link onto serine residues in the core protein of a proteoglycan." [ISBN:0815316194] synonym: "heparan sulfate proteoglycan anabolism, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan formation, linkage to polypeptide" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, linkage to polypeptide" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, linkage to polypeptide" EXACT [] synonym: "heparin proteoglycan biosynthetic process, linkage to polypeptide" RELATED [] is_a: GO:0018242 ! protein O-linked glycosylation via serine is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015014 name: heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharide chain component of heparan sulfate proteoglycan." [GOC:ai] synonym: "heparan sulfate proteoglycan anabolism, polysaccharide chain anabolism" EXACT [] synonym: "heparan sulfate proteoglycan chain elongation" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulfate proteoglycan formation, polysaccharide chain formation" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, polysaccharide chain synthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthesis" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, polysaccharide chain biosynthetic process" EXACT [] synonym: "heparin proteoglycan biosynthetic process, polysaccharide chain biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015015 name: heparan sulfate proteoglycan biosynthetic process, enzymatic modification namespace: biological_process def: "The modification, often by sulfation, of sugars incorporated into heparan sulfate after polymerization." [ISBN:0815316194] synonym: "heparan sulfate proteoglycan anabolism, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan formation, enzymatic modification" EXACT [] synonym: "heparan sulfate proteoglycan synthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthesis, enzymatic modification" EXACT [] synonym: "heparan sulphate proteoglycan biosynthetic process, enzymatic modification" EXACT [] synonym: "heparin proteoglycan biosynthetic process, enzymatic modification" RELATED [] is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process relationship: part_of GO:0015012 ! heparan sulfate proteoglycan biosynthetic process [Term] id: GO:0015016 name: [heparan sulfate]-glucosamine N-sulfotransferase activity namespace: molecular_function alt_id: GO:0004393 alt_id: GO:0015022 alt_id: GO:0051910 def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-N-sulfoglucosamine." [EC:2.8.2.8] comment: Note that this activity includes EC:2.8.2.12 (deleted from EC). synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:heparitin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylyl-sulfate:N-desulfoheparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "3'-phosphoadenylylsulfate:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "[heparan sulphate]-glucosamine N-sulphotransferase activity" EXACT [] synonym: "desulfoheparin sulfotransferase activity" EXACT [] synonym: "glucosaminyl N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate 2-N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-deacetylase/N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparan sulfate N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin N-deacetylase/N-sulfotransferase activity" RELATED [] synonym: "heparin N-deacetylase/N-sulphotransferase activity" RELATED [] synonym: "heparin N-sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "heparin-glucosamine N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulfotransferase activity" EXACT [] synonym: "heparitin N-sulphotransferase activity" EXACT [] synonym: "heparitin sulfotransferase activity" EXACT [] synonym: "N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-heparan sulfate sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "N-HSST activity" EXACT [EC:2.8.2.8] synonym: "PAPS:DSH sulfotransferase activity" EXACT [EC:2.8.2.8] synonym: "PAPS:N-desulfoheparin sulfotransferase activity" EXACT [EC:2.8.2.8] xref: EC:2.8.2.8 xref: MetaCyc:HEPARITIN-SULFOTRANSFERASE-RXN xref: reactome:R-HSA-2022860 "NDST1-4 can sulfate a glucosamine residue in heparan to form heparan sulfate (HS)" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0015017 name: obsolete glypican namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product (was misspelled 'glycipan'). synonym: "glypican" EXACT [] is_obsolete: true [Term] id: GO:0015018 name: galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucuronate + 3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein = UDP + 3-beta-D-glucuronosyl-3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosylprotein." [EC:2.4.1.135] synonym: "glucuronosyltransferase I activity" NARROW [EC:2.4.1.135] synonym: "UDP-glucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "UDPglucuronate:3-beta-D-galactosyl-4-beta-D-galactosyl-O-beta-D-xylosyl-protein D-glucuronosyltransferase activity" EXACT [EC:2.4.1.135] synonym: "uridine diphosphate glucuronic acid:acceptor glucuronosyltransferase activity" EXACT [EC:2.4.1.135] xref: EC:2.4.1.135 xref: MetaCyc:2.4.1.135-RXN xref: reactome:R-HSA-1889955 "B3GATs transfer GlcA to tetrasaccharide linker" is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0015019 name: heparan-alpha-glucosaminide N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + heparan alpha-D-glucosaminide = CoA + heparan N-acetyl-alpha-D-glucosaminide." [EC:2.3.1.78] synonym: "acetyl-CoA:alpha-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "acetyl-CoA:heparan-alpha-D-glucosaminide N-acetyltransferase activity" EXACT [EC:2.3.1.78] synonym: "heparin-alpha-glucosaminide N-acetyltransferase activity" RELATED [] xref: EC:2.3.1.78 xref: MetaCyc:2.3.1.78-RXN xref: reactome:R-HSA-1678660 "HGSNAT oligomer acetylates Heparan sulfate chain(3)" xref: reactome:R-HSA-2090085 "HGSNAT oligomer acetylates Heparan chain(1)" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0015020 name: glucuronosyltransferase activity namespace: molecular_function alt_id: GO:0003981 def: "Catalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside." [EC:2.4.1.17] synonym: "1-naphthol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "1-naphthol-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "17-OH steroid UDPGT activity" NARROW [EC:2.4.1.17] synonym: "17beta-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "3-OH androgenic UDPGT activity" NARROW [EC:2.4.1.17] synonym: "3alpha-hydroxysteroid UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-hydroxybiphenyl UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-methylumbelliferone UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "4-nitrophenol UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin monoglucuronide glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "bilirubin UDPGT activity" NARROW [EC:2.4.1.17] synonym: "bilirubin uridine diphosphoglucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "ciramadol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estriol UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "estrone UDPglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "GT activity" EXACT [EC:2.4.1.17] synonym: "morphine glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-hydroxybiphenyl UDP glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenol UDP-glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-nitrophenylglucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "p-phenylphenol glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "phenyl-UDP-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "PNP-UDPGT" RELATED [EC:2.4.1.17] synonym: "pnp-UDPGT activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estradiol-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP glucuronic acid transferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate beta-D-glucuronosyltransferase (acceptor-unspecific)" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronate-bilirubin glucuronyltransferase activity" NARROW [EC:2.4.1.17] synonym: "UDP-glucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDP-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA transferase activity" EXACT [EC:2.4.1.17] synonym: "UDPGA-glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "UDPglucuronate beta-D-glucuronosyltransferase (acceptor-unspecific) activity" NARROW [EC:2.4.1.17] synonym: "UDPGT activity" EXACT [EC:2.4.1.17] synonym: "uridine 5'-diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphate glucuronyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-1,2-diacylglycerol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-4-hydroxybiphenyl glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronoside glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-bilirubin glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estradiol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16-alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol 16alpha-glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronate-estriol glucuronosyltransferase activity" NARROW [EC:2.4.1.17] synonym: "uridine diphosphoglucuronosyltransferase activity" EXACT [EC:2.4.1.17] synonym: "uridine diphosphoglucuronyltransferase activity" EXACT [EC:2.4.1.17] xref: EC:2.4.1.17 xref: MetaCyc:UDP-GLUCURONOSYLTRANSFERASE-RXN xref: reactome:R-HSA-159179 "UGT1A1 tetramer, UGT1A4 transfer GlcA from UDP-GlcA to BMG to form BDG" xref: reactome:R-HSA-159194 "UGT1A1,4 transfer GlcA from UDP-GlcA to BIL to form BMG" xref: reactome:R-HSA-174916 "Formation of N-glucuronides" xref: reactome:R-HSA-174931 "UGTs transfer GlcA from UDP-GlcA to O-centre substrates" xref: reactome:R-HSA-2162099 "abacavir + UDP-glucuronate => abacavir 5'-glucuronide + UDP" xref: reactome:R-HSA-5617143 "B4GAT1:LARGE,GYLTL1B transfers GlcA from UDP-GlcA to Xyl-GlcA" xref: reactome:R-HSA-8941701 "UGT1A10 transfers GlcA from UDP-GlcA to GCTN" is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0015021 name: heparin-sulfate lyase activity namespace: molecular_function def: "Catalysis of the elimination of sulfate; appears to act on linkages between N-acetyl-D-glucosamine and uronate. Product is an unsaturated sugar." [EC:4.2.2.8] synonym: "[heparan sulfate]-sulfate lyase activity" RELATED [] synonym: "heparin-sulfate eliminase activity" RELATED [EC:4.2.2.8] synonym: "heparin-sulphate lyase activity" EXACT [] synonym: "heparitin-sulfate lyase activity" EXACT [] synonym: "heparitinase I" RELATED [EC:4.2.2.8] synonym: "heparitinase II" RELATED [EC:4.2.2.8] xref: EC:4.2.2.8 xref: MetaCyc:4.2.2.8-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0015023 name: obsolete syndecan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "syndecan" EXACT [] is_obsolete: true [Term] id: GO:0015024 name: glucuronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate." [EC:3.1.6.18] synonym: "chondro-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "glucuronate-2-sulphatase activity" EXACT [] synonym: "glucurono-2-sulfatase activity" EXACT [EC:3.1.6.18] synonym: "polysaccharide-2-O-sulfo-D-glucuronate 2-sulfohydrolase activity" EXACT [EC:3.1.6.18] xref: EC:3.1.6.18 xref: MetaCyc:3.1.6.18-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0015025 name: obsolete GPI-anchored membrane-bound receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "GPI-anchored membrane-bound receptor" EXACT [] is_obsolete: true replaced_by: GO:0031225 [Term] id: GO:0015026 name: coreceptor activity namespace: molecular_function alt_id: GO:0015027 alt_id: GO:0015028 def: "Combining with an extracellular or intracellular messenger, and in cooperation with a nearby primary receptor, initiating a change in cell activity." [GOC:go_curators] synonym: "coreceptor, insoluble ligand activity" RELATED [GOC:mah] synonym: "coreceptor, soluble ligand activity" RELATED [GOC:mah] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0015029 name: obsolete internalization receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because internalization is a process, not a ligand to which a receptor might bind. synonym: "internalization receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0015030 name: Cajal body namespace: cellular_component def: "A class of nuclear body, first seen after silver staining by Ramon y Cajal in 1903, enriched in small nuclear ribonucleoproteins, and certain general RNA polymerase II transcription factors; ultrastructurally, they appear as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter; involved in aspects of snRNP biogenesis; the protein coilin serves as a marker for Cajal bodies. Some argue that Cajal bodies are the sites for preassembly of transcriptosomes, unitary particles involved in transcription and processing of RNA." [NIF_Subcellular:nlx_subcell_090901, PMID:10944589, PMID:11031238, PMID:7559785] synonym: "coiled body" EXACT [] synonym: "Gemini of coiled bodies" RELATED [] synonym: "Gems" RELATED [] xref: NIF_Subcellular:nlx_subcell_090901 xref: Wikipedia:Cajal_body is_a: GO:0016604 ! nuclear body [Term] id: GO:0015031 name: protein transport namespace: biological_process alt_id: GO:0015831 def: "The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir synonym: "enzyme transport" NARROW [] is_a: GO:0015833 ! peptide transport is_a: GO:0045184 ! establishment of protein localization [Term] id: GO:0015032 name: obsolete storage protein import into fat body namespace: biological_process def: "OBSOLETE. The incorporation of hemolymph proteins by cells of the fat body of holometabolous insects, during the final larval stage. Uptake of these proteins prepares the insect for pupation and metamorphosis, since insect pupae do not feed and therefore depend on material that has been accumulated during larval life." [GOC:bf, PMID:10231363] comment: The reason for obsoletion is that the data from the paper for which the term was requested can be accurately described using 'receptor-mediated endocytosis', https://github.com/geneontology/go-ontology/issues/12935 synonym: "fat body metabolic process" BROAD [] synonym: "fat body metabolism" BROAD [] synonym: "fat body storage protein uptake" EXACT [] synonym: "import of storage protein into fat body" EXACT [] synonym: "storage protein import by fat body cells" EXACT [] synonym: "storage protein import into fat body cells" EXACT [] synonym: "storage protein transport into fat body cells" EXACT [] synonym: "storage protein uptake into fat body cells" EXACT [] is_obsolete: true [Term] id: GO:0015034 name: obsolete cytochrome P450 activity namespace: molecular_function def: "OBSOLETE. A cytochrome b-like protein that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes: typically monooxygenases acting on, typically, lipophilic substrates. The characteristic mode of action of these enzymes is not electron transfer (some P450 enzymes probably do not even involve the reversible Fe(II)/Fe(III) equilibrium), but rather oxygen atom transfer." [ISBN:0198547684, PMID:1655423] comment: This term was made obsolete because it is a grouping term representing a set of gene products. synonym: "cytochrome P450 activity" EXACT [] is_obsolete: true consider: GO:0019825 [Term] id: GO:0015035 name: protein disulfide oxidoreductase activity namespace: molecular_function alt_id: GO:0008895 def: "Catalysis of the reaction: a protein with reduced sulfide groups = a protein with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] synonym: "haem lyase disulphide oxidoreductase activity" NARROW [] synonym: "heme lyase disulfide oxidoreductase activity" NARROW [] synonym: "protein disulphide oxidoreductase activity" EXACT [] synonym: "thioredoxin activity" NARROW [GOC:mah, GOC:vw] xref: MetaCyc:DISULFOXRED-RXN xref: reactome:R-HSA-1307802 "MIA40:ERV1 (CHCHD4:GFER) oxidizes cysteine residues to cystine disulfide bonds" xref: reactome:R-HSA-3299753 "CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1" is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015036 name: disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds." [MetaCyc:DISULFOXRED-RXN] synonym: "disulphide oxidoreductase activity" EXACT [] xref: reactome:R-HSA-1222417 "TrxA reactivates AhpC" xref: reactome:R-HSA-1222644 "TrxA/B1 reactivates Tpx" xref: reactome:R-HSA-1222655 "AhpD reactivates AhpC" xref: reactome:R-HSA-1222690 "DlaT reactivates AhpD" xref: reactome:R-HSA-264997 "Oxidation of cysteine to cystine in Proinsulin" is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0015037 name: peptide disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: a peptide with reduced sulfide groups = a peptide with oxidized disulfide bonds." [GOC:mah, MetaCyc:DISULFOXRED-RXN] synonym: "peptide disulphide oxidoreductase activity" EXACT [] is_a: GO:0015036 ! disulfide oxidoreductase activity [Term] id: GO:0015038 name: glutathione disulfide oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + electron acceptor = glutathione disulfide + electron donor." [GOC:mah] synonym: "glutaredoxin" RELATED [] synonym: "glutathione disulphide oxidoreductase activity" EXACT [] xref: reactome:R-HSA-111746 "glutaredoxin (oxidized) + glutathione (reduced) => glutaredoxin (reduced) + glutathione (oxidized)" is_a: GO:0015037 ! peptide disulfide oxidoreductase activity [Term] id: GO:0015039 name: NADPH-adrenodoxin reductase activity namespace: molecular_function def: "Catalysis of the reaction: oxidized adrenodoxin + NADPH + H+ = reduced adrenodoxin + NADP+." [EC:1.18.1.6, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; under physiological conditions adrenodoxin reduction by adrenodoxin reductase is coupled with electron transfer from AdR to P450, which catalyzes an irreversible monooxygenation reaction. This term should therefore be used to annotate gene products that catalyze the reduction of oxidized adrenodoxin; also consider annotating to the molecular function term 'ferredoxin-NADP+ reductase activity ; GO:0004324'. synonym: "adrenodoxin reductase activity" BROAD [EC:1.18.1.2] synonym: "adrenodoxin-type ferredoxin reductase activity" EXACT [GOC:kd] synonym: "NADPH:adrenodoxin oxidoreductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.6 xref: MetaCyc:RXN-13685 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015040 name: obsolete electron transfer flavoprotein, group I namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that links acyl-CoA dehydrogenase reactions with the respiratory chain, such as in the fatty acid degradation pathway." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein, group I" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015041 name: obsolete electron transfer flavoprotein, group II namespace: molecular_function def: "OBSOLETE. An electron transfer flavoprotein that functions as a housekeeping protein that is synthesized only under certain specific growth conditions and receives electrons from the oxidation of specific substrates, e.g. trimethylamine, carnitine and in nitrogen fixation." [PMID:8599534] comment: This term was made obsolete because it refers to a class of gene products. synonym: "electron transfer flavoprotein, group II" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015042 name: trypanothione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + trypanothione = NADPH + H+ + trypanothione disulfide." [EC:1.8.1.12] comment: Note that this function was formerly EC:1.6.4.8. synonym: "N(1),N(8)-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "N1,N8-bis(glutathionyl)spermidine reductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH2:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "NADPH:trypanothione oxidoreductase activity" EXACT [EC:1.8.1.12] synonym: "trypanothione reductase activity" EXACT [] synonym: "trypanothione-disulphide reductase activity" EXACT [] synonym: "trypanothione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.12] xref: EC:1.8.1.12 xref: MetaCyc:1.8.1.12-RXN xref: RHEA:16757 is_a: GO:0015036 ! disulfide oxidoreductase activity is_a: GO:0016668 ! oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor [Term] id: GO:0015043 name: leghemoglobin reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferrileghemoglobin = NADP+ + 2 ferroleghemoglobin." [EC:1.6.2.6] synonym: "ferric leghemoglobin reductase activity" EXACT [EC:1.6.2.6] synonym: "NAD(P)H:ferrileghemoglobin oxidoreductase activity" EXACT [EC:1.6.2.6] xref: EC:1.6.2.6 xref: MetaCyc:LEGHEMOGLOBIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0015044 name: rubredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD+ = oxidized rubredoxin + NADH + H+." [EC:1.18.1.1] synonym: "dihydronicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "DPNH-rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.1] synonym: "NADH:rubredoxin reductase activity" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide--rubredoxin reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--NAD reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin--nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.1] synonym: "rubredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.1] xref: EC:1.18.1.1 xref: MetaCyc:RUBREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015045 name: rubredoxin-NAD(P)+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NAD(P)+ = oxidized rubredoxin + NAD(P)H + H+." [EC:1.18.1.4] synonym: "dinucleotide phosphate reductase activity" RELATED [EC:1.18.1.4] synonym: "NAD(P)--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NAD(P)H--rubredoxin oxidoreductase activity" EXACT [EC:1.18.1.4] synonym: "NADPH:rubredoxin reductase activity" EXACT [] synonym: "rubredoxin--nicotinamide adenine activity" RELATED [EC:1.18.1.4] synonym: "rubredoxin--nicotinamide adenine dinucleotide (phosphate) reductase activity" EXACT [EC:1.18.1.4] synonym: "rubredoxin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.18.1.4] xref: EC:1.18.1.4 xref: MetaCyc:RUBREDOXIN--NADP+-REDUCTASE-RXN is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015046 name: rubredoxin-NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced rubredoxin + NADP+ = oxidized rubredoxin + NADPH + H+." [EC:1.18.1.-] xref: EC:1.18.1 is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0015047 name: NADPH-cytochrome-c2 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + 2 ferricytochrome c2 = NADP+ + 2 ferrocytochrome c2." [EC:1.6.2.5] synonym: "cytochrome c2 reductase (reduced nicotinamide adinine dinucleotide phosphate, NADPH)" EXACT [EC:1.6.2.5] synonym: "NADPH:ferricytochrome-c2 oxidoreductase activity" EXACT [EC:1.6.2.5] synonym: "reductase, cytochrome c2 (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.6.2.5] xref: EC:1.6.2.5 xref: MetaCyc:NADPH--CYTOCHROME-C2-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor [Term] id: GO:0015048 name: phthalate dioxygenase reductase activity namespace: molecular_function def: "Catalysis of the transfer of electrons between pyridine nucleotides (obligatory two-electron carriers) and hemes or (2Fe-2S) centers (obligatory one-electron carriers) in respiration, photosynthesis, and many oxygenase systems." [PMID:7589982] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0015049 name: methane monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methane + NAD(P)H + H+ + O2 = methanol + NAD(P)+ + H2O." [EC:1.14.13.25] synonym: "methane hydroxylase activity" EXACT [EC:1.14.13.25] synonym: "methane,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.25] xref: EC:1.14.13.25 xref: KEGG:R01142 xref: KEGG:R01143 xref: MetaCyc:METHANE-MONOOXYGENASE-RXN xref: RHEA:13637 xref: RHEA:13641 xref: UM-BBD_enzymeID:e0007 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0015050 name: methane monooxygenase complex namespace: cellular_component def: "A protein complex that possesses methane monooxygenase activity; dimeric and trimeric complexes have been characterized." [BRENDA:1.14.13.25, GOC:mah] is_a: GO:1902494 ! catalytic complex [Term] id: GO:0015051 name: obsolete X-opioid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an opioid to initiate a change in cell activity, with the pharmacological characteristics of X-opioid receptors." [InterPro:IPR001420] comment: This term was made obsolete because the receptor is defined based on its pharmacological properties. synonym: "X-opioid receptor activity" EXACT [] is_obsolete: true consider: GO:0001626 [Term] id: GO:0015052 name: beta3-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta3 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0015053 name: obsolete opsin namespace: molecular_function def: "OBSOLETE. Hydrophobic glycoprotein to which 11-cis-retinal binds as a Schiff base (in rhodopsin) or 3,4-didehydro-11-cis-retinal binds as a Schiff base in cyanopsin and porphyropsin." [ISBN:0198547684] comment: This term was made obsolete because it refers to a class of proteins. synonym: "opsin" EXACT [] is_obsolete: true consider: GO:0007602 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015054 name: gastrin receptor activity namespace: molecular_function def: "Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity." [GOC:ai, GOC:signaling] synonym: "cholecystokinin-B receptor activity" RELATED [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0015055 name: secretin receptor activity namespace: molecular_function def: "Combining with secretin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0015056 name: corticotrophin-releasing factor receptor activity namespace: molecular_function def: "Combining with the corticotrophin-releasing factor family of ligands, including the urocortins, to initiate a change in cell activity." [PMID:12032352] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0015057 name: thrombin-activated receptor activity namespace: molecular_function alt_id: GO:0010655 def: "A G protein-coupled receptor activity that is activated by cleavage by thrombin, which exposes a tethered ligand corresponding to the new N-terminus, which binds to the receptor and activates it." [GOC:ai, GOC:pg, PMID:20423334] synonym: "thrombin receptor activity" EXACT [] synonym: "thrombin receptor activity, G-protein coupled" EXACT [] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0015058 name: obsolete epidermal growth factor-like module containing hormone receptor activity namespace: molecular_function alt_id: GO:0016523 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "EGF-like module containing hormone receptor activity" EXACT [] synonym: "Egr1 hormone receptor" EXACT [] synonym: "epidermal growth factor-like module containing hormone receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0015059 name: obsolete blue-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "blue-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015060 name: obsolete green-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "green-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015061 name: obsolete red-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "red-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009585 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015062 name: obsolete violet-sensitive opsin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of proteins. synonym: "violet-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015063 name: obsolete long-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption above 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "long-wave-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015064 name: obsolete UV-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption below 400 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "UV-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007604 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0015065 name: uridine nucleotide receptor activity namespace: molecular_function def: "Combining with UTP or UDP to initiate a change in cell activity." [GOC:curators, PMID:8537335] synonym: "purinoceptor type U" EXACT [] is_a: GO:0071553 ! G protein-coupled pyrimidinergic nucleotide receptor activity [Term] id: GO:0015066 name: alpha-amylase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of alpha-amylase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0015067 name: amidinotransferase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an amidino group to an acceptor." [GOC:ai] synonym: "transamidinase activity" EXACT [] xref: EC:2.1.4 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0015068 name: glycine amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + glycine = L-ornithine + guanidinoacetate." [EC:2.1.4.1] synonym: "arginine-glycine amidinotransferase activity" EXACT [EC:2.1.4.1] synonym: "arginine-glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "glycine transamidinase activity" EXACT [EC:2.1.4.1] synonym: "L-arginine:glycine amidinotransferase activity" EXACT [EC:2.1.4.1] xref: EC:2.1.4.1 xref: MetaCyc:GLYCINE-AMIDINOTRANSFERASE-RXN xref: reactome:R-HSA-71275 "arginine + glycine => ornithine + guanidoacetate" xref: RHEA:13201 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015069 name: scyllo-inosamine-4-phosphate amidinotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-amino-1-deoxy-scyllo-inositol 4-phosphate + L-arginine = 1-guanidino-1-deoxy-scyllo-inositol 4-phosphate + L-ornithine." [EC:2.1.4.2, RHEA:13265] synonym: "inosamine-P amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "inosamine-phosphate amidinotransferase activity" EXACT [] synonym: "L-arginine:1-amino-1-deoxy-scyllo-inositol-4-phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine phosphate amidinotransferase activity" EXACT [EC:2.1.4.2] synonym: "L-arginine:inosamine-P-amidinotransferase activity" EXACT [EC:2.1.4.2] xref: EC:2.1.4.2 xref: KEGG:R03477 xref: MetaCyc:2.1.4.2-RXN xref: RHEA:13265 is_a: GO:0015067 ! amidinotransferase activity [Term] id: GO:0015070 name: obsolete toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living organisms." [GOC:jl] comment: This term was made obsolete because it represents a classification of molecules and not a molecular function. synonym: "toxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0015072 name: obsolete phosphatidylinositol 3-kinase, class I, catalyst activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0015073 name: obsolete phosphatidylinositol 3-kinase, class I, regulator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 3-phosphate." [EC:2.7.1.137] comment: This term was made obsolete because it refers to a class of gene products. synonym: "phosphatidylinositol 3-kinase, class I, regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0046935 [Term] id: GO:0015074 name: DNA integration namespace: biological_process def: "The process in which a segment of DNA is incorporated into another, usually larger, DNA molecule such as a chromosome." [GOC:mah] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0015075 name: ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other." [GOC:dgf, GOC:mtg_transport, ISBN:0815340729] synonym: "ion transporter activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015076 name: obsolete heavy metal ion transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of heavy metal ions into, out of or within a cell, or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy metal ion transporter activity" EXACT [] is_obsolete: true consider: GO:0046873 [Term] id: GO:0015077 name: monovalent inorganic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a inorganic cations with a valency of one from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0015078 name: proton transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a proton from one side of a membrane to the other." [GOC:ai] synonym: "hydrogen ion transmembrane transporter activity" EXACT [] synonym: "proton transporter activity" EXACT [] xref: reactome:R-HSA-1222516 "Intraphagosomal pH is lowered to 5 by V-ATPase" xref: reactome:R-HSA-164834 "Enzyme-bound ATP is released" xref: reactome:R-HSA-170026 "Protons are translocated from the intermembrane space to the matrix" xref: reactome:R-HSA-74723 "Endosome acidification" xref: reactome:R-HSA-917841 "Acidification of Tf:TfR1 containing endosome" is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity [Term] id: GO:0015079 name: potassium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0015388 alt_id: GO:0022817 def: "Enables the transfer of potassium ions (K+) from one side of a membrane to the other." [GOC:ai] synonym: "potassium transporter activity" EXACT [] synonym: "potassium uptake permease activity" RELATED [] synonym: "potassium uptake transmembrane transporter activity" RELATED [] xref: RHEA:29463 is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015080 name: silver ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silver (Ag) ions from one side of a membrane to the other." [GOC:ai] synonym: "silver transporter activity" EXACT [] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015081 name: sodium ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0022816 def: "Enables the transfer of sodium ions (Na+) from one side of a membrane to the other." [GOC:ai, GOC:BHF] synonym: "sodium transporter activity" EXACT [] is_a: GO:0015077 ! monovalent inorganic cation transmembrane transporter activity is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015083 name: aluminum ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0015084 def: "Enables the transfer of aluminum (Al) ions from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aluminium ion transporter activity" EXACT [] synonym: "aluminium resistance permease activity" EXACT [] synonym: "aluminum resistance permease activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015085 name: calcium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of calcium (Ca) ions from one side of a membrane to the other." [GOC:dgf] xref: reactome:R-HSA-2534359 "CatSper Channel Mediated Calcium Transport" is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015086 name: cadmium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cadmium (Cd) ions from one side of a membrane to the other." [GOC:dgf] synonym: "zinc, cadmium uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015087 name: cobalt ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cobalt (Co) ions from one side of a membrane to the other." [GOC:dgf] synonym: "cobalt, zinc uptake permease activity" RELATED [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] xref: RHEA:28578 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015089 name: high-affinity copper ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a copper ions (Cu2+) from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:9.A.11.1.1] synonym: "high affinity copper ion transmembrane transporter activity" EXACT [] synonym: "high affinity copper transporter activity" EXACT [] is_a: GO:0005375 ! copper ion transmembrane transporter activity [Term] id: GO:0015090 name: low-affinity ferric iron ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Fe2+(out) = Fe2+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:9.A.9.1.1] synonym: "low affinity iron ion transmembrane transporter activity" EXACT [] synonym: "low affinity iron transporter activity" EXACT [] is_a: GO:0005381 ! iron ion transmembrane transporter activity [Term] id: GO:0015091 name: ferric iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other." [ISBN:0198506732] comment: Ferric iron is rarely transported in the free form. Some bacteria have a system in which an outer membrane protein takes iron away from host ferritin or lactoferrin and transport it to a Fe3+ binding protein in the periplasm. The periplasmic protein then delivers the Fe3+ to a transport system located in the cytoplasmic membrane. Consider also GO:0015343 siderophore transmembrane transporter activity. is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072510 ! trivalent inorganic cation transmembrane transporter activity [Term] id: GO:0015092 name: high-affinity ferric iron transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric iron (Fe(III) or Fe3+) ions from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:ai, PMID:1447137] comment: https://github.com/geneontology/go-ontology/issues/14372 synonym: "high affinity ferric uptake transmembrane transporter activity" RELATED [] is_a: GO:0015091 ! ferric iron transmembrane transporter activity [Term] id: GO:0015093 name: ferrous iron transmembrane transporter activity namespace: molecular_function alt_id: GO:0015639 def: "Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other." [ISBN:0198506732] synonym: "ferrous iron uptake transmembrane transporter activity" RELATED [] xref: reactome:R-HSA-1362417 "Mitoferrin translocates iron from the mitochondrial intermembrane space to the mitochondrial matrix" xref: reactome:R-HSA-442368 "SLC40A1:HEPH:6Cu2+ transports Fe2+ from cytosol to extracellular region" xref: RHEA:28486 is_a: GO:0005381 ! iron ion transmembrane transporter activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015094 name: lead ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lead (Pb) ions from one side of a membrane to the other." [GOC:ai] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015095 name: magnesium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of magnesium (Mg) ions from one side of a membrane to the other." [GOC:dgf] xref: reactome:R-HSA-442661 "SLC41A1,2 transport Mg2+ from extracellular region to cytosol" xref: reactome:R-HSA-5336453 "NIPAs transport Mg2+ from extracellular region to cytosol" xref: reactome:R-HSA-5336454 "MMGT1 transports Mg2+ from cytosol to Golgi lumen" xref: reactome:R-HSA-5336466 "MRS2 transports Mg2+ from cytosol to mitochondrial matrix" xref: reactome:R-HSA-5339528 "TUSC3 transports Mg2+ from extracellular region to cytosol" xref: reactome:R-HSA-5339538 "MAGT1 transports Mg2+ from extracellular region to cytosol" xref: RHEA:29827 is_a: GO:0046873 ! metal ion transmembrane transporter activity [Term] id: GO:0015096 name: obsolete manganese resistance permease activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because the term is undefined and we don't know the mechanism so we can't make a correct definition. synonym: "manganese resistance permease activity" EXACT [] is_obsolete: true [Term] id: GO:0015097 name: mercury ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of mercury (Hg) ions from one side of a membrane to the other." [GOC:ai] xref: RHEA:32815 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015098 name: molybdate ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of molybdate (MoO4 2-) ions from one side of a membrane to the other. Molybdate is the bivalent anion derived from molybdic acid." [ISBN:0198506732] synonym: "molybdate transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015099 name: nickel cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nickel (Ni) cations from one side of a membrane to the other." [GOC:ai] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" RELATED [] xref: RHEA:29831 is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015100 name: vanadium ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of vanadium (V) ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0046915 ! transition metal ion transmembrane transporter activity [Term] id: GO:0015101 name: organic cation transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic cations from one side of a membrane to the other. Organic cations are atoms or small molecules with a positive charge that contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-2161500 "abacavir [extracellular] => abacavir [cytosol]" xref: reactome:R-HSA-549129 "OCT1 transports organic cations into hepatic cells" xref: reactome:R-HSA-549279 "OCT2 mediates tubular uptake of organic cations in the kidney" xref: reactome:R-HSA-549304 "OCT3 mediates renal clearance of organic cations" xref: reactome:R-HSA-549322 "OCT1 transports organic cations out of hepatic cells" xref: reactome:R-HSA-561054 "OCT2 mediates tubular secretion of organic cations in the kidney" xref: reactome:R-HSA-561072 "OCT3 mediates renal uptake of organic cations" is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0015103 name: inorganic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic anions from one side of a membrane to the other. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:ai] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015104 name: antimonite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of antimonite from one side of a membrane to the other." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015105 name: arsenite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of arsenite from one side of a membrane to the other." [GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015106 name: bicarbonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicarbonate from one side of a membrane to the other. Bicarbonate is the hydrogencarbonate ion, HCO3-." [GOC:ai] xref: reactome:R-HSA-2752067 "BESTs transport cytosolic HCO3- to extracellular region" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015107 name: chlorate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chlorate, ClO3-, from one side of a membrane to the other." [CHEBI:49709, GOC:curators] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015108 name: chloride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chloride ions from one side of a membrane to the other." [GOC:ai] synonym: "chloride ion transmembrane transporter activity" EXACT [GOC:pr] xref: reactome:R-HSA-5678863 "CFTR transports Cl- from cytosol to extracellular region" xref: reactome:R-HSA-5678992 "Ivacaftor:CFTR G551D transports Cl- from cytosol to extracellular region" xref: RHEA:29823 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015109 name: chromate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of chromate from one side of a membrane to the other. Chromate is the anion of chromic acid, H2CrO4 (aq) or CrO3." [GOC:ai] xref: RHEA:32819 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015110 name: cyanate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyanate, NCO-, the anion of cyanic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015111 name: iodide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of iodide ions from one side of a membrane to the other." [GOC:ai] xref: reactome:R-HSA-209910 "Iodide is taken up by thyroid epithelial cells" xref: reactome:R-HSA-5627802 "SLC26A4 transports I- from cytosol to extracellular region" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015112 name: nitrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrate ions (NO3-) from one side of a membrane to the other." [GOC:ai] synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015113 name: nitrite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrite (NO2-) ions from one side of a membrane to the other." [GOC:ai] synonym: "nitrite/nitrate porter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015114 name: phosphate ion transmembrane transporter activity namespace: molecular_function alt_id: GO:1901677 def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other." [GOC:ai] synonym: "phosphate transmembrane transporter activity" RELATED [GOC:vw] xref: RHEA:32823 is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015115 name: silicate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silicates from one side of a membrane to the other. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [CHEBI:48123, GOC:ai] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015116 name: sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfate ions, SO4(2-), from one side of a membrane to the other." [GOC:ai] synonym: "sulfate permease activity" RELATED [] synonym: "sulphate transporter activity" EXACT [] xref: reactome:R-HSA-427555 "SLC26A1,2 cotransport SO4(2-), H+ from extracellular region to cytosol" xref: reactome:R-HSA-8875871 "SLC26A11 transports SO4(2-) from extracellular region to cytosol" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015117 name: thiosulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thiosulfate ions, S2O3(2-), from one side of a membrane to the other." [GOC:ai] synonym: "thiosulfate permease activity" RELATED [] synonym: "thiosulphate transporter activity" EXACT [] xref: RHEA:32807 is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015119 name: hexose phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of hexose phosphate from one side of a membrane to the other. Hexose phosphates is any of a group of monophosphorylated aldoses with a chain of six carbon atoms in the molecule." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015120 name: phosphoglycerate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphoglycerates from one side of a membrane to the other. Phosphoglycerates are important intermediates in glycolysis and 3-phosphoglycerate is a precursor in serine biosynthesis." [GOC:ai] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015121 name: phosphoenolpyruvate:phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphoenolpyruvate(out) + phosphate(in) = phosphoenolpyruvate(in) + phosphate(out)." [GOC:bf, GOC:jl] synonym: "phosphoenolpyruvate/phosphate translocator" EXACT [] synonym: "PPT" BROAD [PMID:10488230] is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0089721 ! phosphoenolpyruvate transmembrane transporter activity [Term] id: GO:0015123 name: acetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acetate from one side of a membrane to the other. Acetate is the 2-carbon carboxylic acid ethanoic acid." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015124 name: allantoate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of allantoate from one side of a membrane to the other. Allantoate is the end product of purine metabolism in mammals and some fish, formed form allantoin. It is widely distributed in plants as an important source of stored nitrogen." [GOC:ai, ISBN:0198547684] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015125 name: bile acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bile acid from one side of a membrane to the other. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:ai] xref: reactome:R-HSA-194079 "SLCO1B3 transports ALB:(GCCA, TCCA) from extracellular region to cytosol" xref: reactome:R-HSA-194083 "SLCO1B1 transports ALB:(GCCA,TCCA) from extracellular region to cytosol" xref: reactome:R-HSA-194130 "Transport (influx) of bile salts and acids by OATP-A" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015126 name: canalicular bile acid transmembrane transporter activity namespace: molecular_function def: "The directed movement of bile acid and bile salts out of a hepatocyte and into the bile canaliculus by means of an agent such as a transporter or pore. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015125 ! bile acid transmembrane transporter activity [Term] id: GO:0015127 name: bilirubin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other. Bilirubin is a linear tetrapyrrole produced in the reticuloendothelial system from biliverdin and transported to the liver as a complex with serum albumin. In the liver, bilirubin is converted to bilirubin bisglucuronide, which is excreted in the bile." [GOC:ai, ISBN:0198547684] xref: reactome:R-HSA-5679041 "ABCC2 transports BMG,BDG from cytosol to extracellular region" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015128 name: gluconate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose." [GOC:ai, ISBN:0198506732] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0015129 name: lactate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lactate from one side of a membrane to the other. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] xref: reactome:R-HSA-373867 "BSG:MCTs cotransport LACT, H+ from extracellular region to cytosol" xref: reactome:R-HSA-373875 "BSG:MCTs cotransport LACT, H+ from cytosol to extracellular region" is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015130 name: mevalonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of mevalonate from one side of a membrane to the other. Mevalonate is the anion of mevalonic acid; its (R)-enantiomer is a strategic intermediate derived from hydroxymethylglutaryl-CoA in the biosynthesis of polyprenyl compounds." [GOC:ai, ISBN:0198506732] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015131 name: oxaloacetate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxaloacetate, the anion of oxobutanedioic acid, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015132 name: prostaglandin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of prostaglandins from one side of a membrane to the other. A prostaglandin is any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [GOC:ai] synonym: "prostaglandin/thromboxane transporter activity" BROAD [] xref: reactome:R-HSA-879528 "SLCO2A1 transports PGT substrates from extracellular region to cytosol" is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0071714 ! icosanoid transmembrane transporter activity [Term] id: GO:0015133 name: uronic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uronic acid from one side of a membrane to the other. Uronic acids are any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015134 name: hexuronate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015163 def: "Enables the transfer of hexuronates from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "hexuronide transmembrane transporter activity" EXACT [] is_a: GO:0015133 ! uronic acid transmembrane transporter activity [Term] id: GO:0015135 name: glucuronate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucuronate from one side of a membrane to the other. Glucuronate is the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity [Term] id: GO:0015136 name: sialic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sialic acid from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015137 name: citrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, from one side of a membrane to the other." [GOC:ai] synonym: "tricarboxylate transport protein" RELATED [] {comment="WIkipedia:Mitochondrial_carrier"} xref: reactome:R-HSA-433104 "NACT co-transports trivalent citrate and a sodium ion" is_a: GO:0015142 ! tricarboxylic acid transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015138 name: fumarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fumarate from one side of a membrane to the other. Fumarate is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015139 name: alpha-ketoglutarate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alpha-ketoglutarate from one side of a membrane to the other. Alpha-ketoglutarate (or oxoglutarate) is a compound with important roles in carbohydrate and amino acid metabolism, especially in transamination reactions and as a component of the TCA cycle." [GOC:ai, ISBN:0198547684] synonym: "2-oxoglutarate transporter activity" EXACT [] xref: reactome:R-HSA-372480 "2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]" is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity [Term] id: GO:0015140 name: malate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of malate from one side of a membrane to the other. Malate is a chiral hydroxydicarboxylic acid, hydroxybutanedioic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [GOC:ai] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015141 name: succinate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of succinate, the dianion of ethane dicarboxylic acid, from one side of a membrane to the other." [ISBN:0198506732] synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" RELATED [] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015142 name: tricarboxylic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tricarboxylic acids from one side of a membrane to the other. Tricarboxylic acid are organic acids with three COOH groups." [GOC:ai] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: reactome:R-HSA-372449 "phosphoenolpyruvate [mitochondrial matrix] + citrate [cytosol] => phosphoenolpyruvate [cytosol] + citrate [mitochondrial matrix]" xref: reactome:R-HSA-75849 "Transport of Citrate from Mitochondrial Matrix to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0015143 name: urate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of urate from one side of a membrane to the other. Urate is the anion of uric acid, 2,6,8-trioxypurine, the end product of purine metabolism in certain mammals and the main excretory product in uricotelic animals." [GOC:ai] synonym: "uric acid transmembrane transporter activity" EXACT [] xref: reactome:R-HSA-2872497 "SLC17A3-2 transports cytosolic urate to extracellular region" xref: reactome:R-HSA-561253 "SLC22A12 exchanges extracellular urate for cytosolic LACT" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:1901702 ! salt transmembrane transporter activity [Term] id: GO:0015144 name: carbohydrate transmembrane transporter activity namespace: molecular_function alt_id: GO:1901476 def: "Enables the transfer of carbohydrate from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "carbohydrate transporter activity" RELATED [] synonym: "sugar transporter" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015145 name: monosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a monosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0015146 name: pentose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pentose sugar from one side of a membrane to the other. Pentose is a monosaccharide with 5 carbon atoms," [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015147 name: L-arabinose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-arabinose from one side of a membrane to the other. Arabinose occurs free, for example in the heartwood of many conifers and in the combined states, in both furanose and pyranose forms, as a constituent of various plant hemicelluloses, bacterial polysaccharides, etc." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015148 name: D-xylose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-xylose from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015146 ! pentose transmembrane transporter activity [Term] id: GO:0015149 name: hexose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a hexose sugar, a monosaccharide with 6 carbon atoms, from one side of a membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-189242 "SLC2A2 tetramer transports Fru, Gal, Glc from cytosol to extracellular region" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity [Term] id: GO:0015150 name: fucose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fucose from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015151 name: alpha-glucoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alpha-glucosides from one side of a membrane to the other. Alpha-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] is_a: GO:0042947 ! glucoside transmembrane transporter activity [Term] id: GO:0015152 name: glucose-6-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glucose-6-phosphate from one side of a membrane to the other. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015153 name: rhamnose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of rhamnose from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015154 name: disaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of disaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity [Term] id: GO:0015155 name: lactose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019189 def: "Enables the transfer of lactose from one side of a membrane to the other. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "lactose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015156 name: melibiose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of melibiose from one side of a membrane to the other. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose and occurs as a constituent of the trisaccharide raffinose or in the exudates and nectaries of a number of plants." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015157 name: oligosaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oligosaccharide from one side of a membrane to the other." [GOC:jl, GOC:mtg_transport, ISBN:0815340729] synonym: "endosomal oligosaccharide transporter" NARROW [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity [Term] id: GO:0015158 name: raffinose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of raffinose from one side of a membrane to the other. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "raffinose permease" RELATED [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity [Term] id: GO:0015159 name: polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polysaccharides from one side of a membrane to the other. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity [Term] id: GO:0015160 name: beta-glucan transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of beta-glucans from one side of a membrane to the other. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015161 name: capsular polysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of capsular-polysaccharides from one side of a membrane to the other. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "capsule polysaccharide transporter activity" EXACT [] is_a: GO:0015159 ! polysaccharide transmembrane transporter activity [Term] id: GO:0015162 name: teichoic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of teichoic acid from one side of a membrane to the other. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015164 name: glucuronoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a glucuronosides from one side of a membrane to the other. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glucuronide transporter activity" EXACT [] is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015165 name: pyrimidine nucleotide-sugar transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleotide-sugar from one side of a membrane to the other. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005338 ! nucleotide-sugar transmembrane transporter activity [Term] id: GO:0015166 name: polyol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a polyol from one side of a membrane to the other. A polyol is any polyhydric alcohol." [ISBN:0198506732] synonym: "sugar/polyol channel activity" NARROW [] xref: reactome:R-HSA-429571 "Co-transport (influx) of myo-inositol/D-chiro-inositol and two Na+ ions by SGLT6" is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015167 name: arabitol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an arabitol from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "arabinitol transporter activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015168 name: glycerol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerol from one side of a membrane to the other. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015169 name: glycerol-3-phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycerol-3-phosphate from one side of a membrane to the other. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015170 name: propanediol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of propanediol from one side of a membrane to the other. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [GOC:ai] is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015171 name: amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015359 def: "Enables the transfer of amino acids from one side of a membrane to the other. Amino acids are organic molecules that contain an amino group and a carboxyl group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "amino acid permease activity" EXACT [] synonym: "amino acid transporter activity" BROAD [] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "general amino acid permease activity" RELATED [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] xref: reactome:R-HSA-210404 "SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+" xref: reactome:R-HSA-210439 "glutamate uptake by astrocytes" xref: reactome:R-HSA-212642 "L-Glutamine transport into neurons" xref: reactome:R-HSA-351963 "SLC6A18 transports Gly from extracellular region to cytosol" xref: reactome:R-HSA-351987 "SLC6A6-mediated uptake of taurine and beta-alanine" xref: reactome:R-HSA-352029 "SLC6A12 (BGT-1)-mediated uptake of GABA and betaine" xref: reactome:R-HSA-352052 "SLC6A20 cotransports L-Pro, Na+ from the extracellular region to cytosol" xref: reactome:R-HSA-352059 "SLC6A15-mediated amino acid uptake" xref: reactome:R-HSA-352103 "SLC43A1 (LAT3)-mediated uptake of large neutral amino acids" xref: reactome:R-HSA-352107 "SLC43A2 (LAT4)-mediated uptake of large neutral amino acids" xref: reactome:R-HSA-352108 "SLC38A2 (ATA2)-mediated uptake of neutral amino acids" xref: reactome:R-HSA-352119 "SLC38A1 (ATA1)-mediated uptake of neutral amino acids" xref: reactome:R-HSA-352136 "SLC38A4 (ATA3)-mediated uptake of arginine and lysine" xref: reactome:R-HSA-352158 "SLC16A10-mediated uptake of aromatic amino acids" xref: reactome:R-HSA-352174 "SLC38A3-mediated uptake of glutamine, histidine, asparagine, and alanine" xref: reactome:R-HSA-352182 "SLC38A5-mediated uptake of glutamine, histidine, asparagine, and serine" xref: reactome:R-HSA-352191 "SLC7A8-mediated uptake of neutral amino acids" xref: reactome:R-HSA-352232 "SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol" xref: reactome:R-HSA-352347 "SLC1A4-mediated exchange of extracellular serine for cytosolic alanine, threonine, or cysteine" xref: reactome:R-HSA-352354 "SLC1A4-mediated exchange of extracellular cysteine for cytosolic alanine, serine, or threonine" xref: reactome:R-HSA-352364 "SLC1A4-mediated exchange of extracellular alanine for cytosolic serine, threonine, or cysteine" xref: reactome:R-HSA-352371 "SLC1A4-mediated exchange of extracellular threonine for cytosolic alanine, serine, or cysteine" xref: reactome:R-HSA-352379 "SLC1A5-mediated exchange of alanine and glutamine across the plasma membrane" xref: reactome:R-HSA-352385 "SLC1A5-mediated exchange of glutamine and alanine across the plasma membrane" xref: reactome:R-HSA-375405 "SLC36A2 cotransports Gly, L-Pro with H+ from extracellular region to cytosol" xref: reactome:R-HSA-375417 "SLC36A1-mediated uptake of glycine, proline, and alanine" xref: reactome:R-HSA-375473 "SLC6A19 cotransports neutral amino acids, Na+ from extracellular region to cytosol" xref: reactome:R-HSA-375487 "SLC6A14 cotransports SLC6A14 ligands, Cl-, 2Na+ from extracellular region to cytosol" xref: reactome:R-HSA-375768 "SLC7A2, isoform B (CAT-2B)-mediated uptake of cationic amino acids" xref: reactome:R-HSA-375770 "SLC7A3 (CAT-3)-mediated uptake of cationic amino acids" xref: reactome:R-HSA-375776 "SLC7A1 (CAT-1)-mediated uptake of cationic amino acids" xref: reactome:R-HSA-375790 "SLC7A2, isoform A (CAT-2A)-mediated uptake of cationic amino acids" xref: reactome:R-HSA-376200 "SLC7A10-mediated uptake of small neutral amino acids" xref: reactome:R-HSA-378513 "SLC7A11-mediated exchange of extracellular cysteine and cytosolic glutamate" xref: reactome:R-HSA-379415 "SLC7A7:SLC3A2 exchanges L-Arg for L-Leu, Na+ across the plasma membrane" xref: reactome:R-HSA-379426 "SLC7A6 (y+LAT2)-mediated exchange of extracellular leucine for cytosolic arginine" xref: reactome:R-HSA-379432 "SLC7A9:SLC3A1 exchanges L-Arg, CySS-, L-Lys for L-Leu" xref: reactome:R-HSA-888592 "Loading of GABA into clathrin sculpted GABA transport vesicle lumen" xref: reactome:R-HSA-8952726 "SLC38A9 transports L-Arg from lysosomal lumen to cytosol" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity [Term] id: GO:0015172 name: acidic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acidic amino acids from one side of a membrane to the other. Acidic amino acids have a pH below 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "acidic amino acid transporter activity" BROAD [] xref: reactome:R-HSA-372448 "SLC25A12,13 exchange cytosolic L-Glu for mitochondrial matrix L-Asp" is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015173 name: aromatic amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aromatic amino acids from one side of a membrane to the other. Aromatic amino acids have an aromatic ring." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "aromatic amino acid transporter activity" BROAD [] synonym: "hydroxy/aromatic amino acid permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015174 name: basic amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005286 alt_id: GO:0015326 def: "Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "basic amino acid permease activity" EXACT [] synonym: "basic amino acid transporter activity" BROAD [] synonym: "cationic amino acid transmembrane transporter activity" RELATED [] xref: reactome:R-HSA-8932851 "PQLC2 transports L-Arg,L-His,L-Lys from lysosomal lumen to cytosol" xref: reactome:R-HSA-8959781 "SLC25A29 transports basic amino acids from cytosol to mitochondrial matrix" is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015175 name: neutral amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of neutral amino acids from one side of a membrane to the other. Neutral amino acids have a pH of 7." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "neutral amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015176 name: obsolete holin namespace: molecular_function def: "OBSOLETE. Primary function of holins appears to be transport of murein hydrolases across the cytoplasmic membrane to the cell wall of bacteria, where these enzymes hydrolyze the cell wall polymer as a prelude to cell lysis. When chromosomally encoded, these enzymes are therefore autolysins. Holins may also facilitate leakage of electrolytes and nutrients from the cell cytoplasm, thereby promoting cell death. Some catalyze export of nucleases." [TC:1.A.38.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "holin" EXACT [] is_obsolete: true consider: GO:0008565 consider: GO:0019835 [Term] id: GO:0015179 name: L-amino acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an L-amino acid from one side of a membrane to the other. L-amino acids are the L-enantiomers of amino acids." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-amino acid transporter activity" BROAD [] xref: reactome:R-HSA-212614 "Glutamine transport from astrocytes" is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015180 name: L-alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-alanine from one side of a membrane to the other. L-alanine is the L-enantiomer of 2-aminopropanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "L-alanine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity [Term] id: GO:0015181 name: arginine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005288 def: "Enables the stereospecific transfer of arginine, 2-amino-5-guanidinopentanoic acid, across a biological membrane." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "arginine permease activity" EXACT [] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-arginine transporter activity" NARROW [] xref: RHEA:32143 is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity [Term] id: GO:0015182 name: L-asparagine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-asparagine from one side of a membrane to the other. L-asparagine is the L-enantiomer of alpha-aminosuccinamic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "asparagine/glutamine permease activity" NARROW [] synonym: "L-asparagine transporter activity" BROAD [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015183 name: L-aspartate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-aspartate from one side of a membrane to the other. L-aspartate is the anion derived from aspartic acid." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-aspartate transporter activity" BROAD [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015556 ! C4-dicarboxylate transmembrane transporter activity [Term] id: GO:0015184 name: L-cystine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-cystine from one side of a membrane to the other." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-cystine transporter activity" BROAD [] xref: reactome:R-HSA-5340130 "CTNS cotransports CySS-, H+ from lysosomal lumen to cytosol" is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015185 name: gamma-aminobutyric acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of gamma-aminobutyric acid from one side of a membrane to the other. Gamma-aminobutyric acid is 4-aminobutyrate (GABA)." [GOC:go_curators, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "4-aminobutanoate transporter activity" EXACT [] synonym: "4-aminobutyrate transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "GABA transporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015186 name: L-glutamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-glutamine from one side of a membrane to the other. L-glutamine is 2-amino-4-carbamoylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "asparagine/glutamine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015187 name: glycine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glycine from one side of a membrane to the other. Glycine is aminoethanoic acid." [GOC:ai] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "glycine transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015188 name: L-isoleucine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-isoleucine from one side of a membrane to the other. L-isoleucine is (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-isoleucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0015189 name: L-lysine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005293 def: "Enables the transfer of L-lysine from one side of a membrane to the other. L-lysine is 2,6-diaminohexanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-lysine permease" RELATED [] synonym: "lysine permease activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015190 name: L-leucine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-leucine from one side of a membrane to the other. L-leucine is 2-amino-4-methylpentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-leucine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0015191 name: L-methionine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-methionine from one side of a membrane to the other. L-methionine is 2-amino-4-(methylthio)butanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-methionine transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0043865 ! methionine transmembrane transporter activity [Term] id: GO:0015192 name: L-phenylalanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-phenylalanine from one side of a membrane to the other. L-phenylalanine is 2-amino-3-phenylpropanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-phenylalanine permease activity" EXACT [] synonym: "L-phenylalanine transporter activity" BROAD [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015193 name: L-proline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005296 def: "Enables the transfer of L-proline from one side of a membrane to the other. L-proline is pyrrolidine-2-carboxylic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "L-proline permease activity" RELATED [] synonym: "L-proline transporter activity" BROAD [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: reactome:R-HSA-8870354 "SLC36A4 transports extracellular L-Pro to the cytosol" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015194 name: L-serine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015511 alt_id: GO:1905361 def: "Enables the transfer of L-serine from one side of a membrane to the other. L-serine is the L-enantiomer of 2-amino-3-hydroxypropanoic acid." [GOC:ai, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0815340729] synonym: "L-serine permease activity" RELATED [] synonym: "L-serine transporter activity" BROAD [] synonym: "serine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] xref: reactome:R-HSA-8932980 "SERINC3,5,(1,2,4) transport L-Ser from cytosol to plasma membrane" is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0022889 ! serine transmembrane transporter activity [Term] id: GO:0015195 name: L-threonine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015512 def: "Enables the transfer of L-threonine from one side of a membrane to the other. L-threonine is (2R*,3S*)-2-amino-3-hydroxybutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-threonine permease activity" RELATED [] synonym: "L-threonine transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" RELATED [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015196 name: L-tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0005299 def: "Enables the transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-tryptophan permease activity" EXACT [] synonym: "L-tryptophan transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] xref: reactome:R-HSA-8870352 "SLC36A4 transports L-Trp from extracellular region to cytosol" is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015199 name: amino-acid betaine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of betaine from one side of a membrane to the other. Betaine is the N-trimethyl derivative of an amino acid." [GOC:ai] synonym: "betaine transmembrane transporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" NARROW [] synonym: "glycine betaine/proline porter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015200 name: methylammonium transmembrane transporter activity namespace: molecular_function def: "Enables directed movement of methylammonium, CH3NH2, from one side of a membrane to the other." [GOC:ai] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity [Term] id: GO:0015203 name: polyamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of polyamines, organic compounds containing two or more amino groups, from one side of a membrane to the other." [GOC:ai] synonym: "amine/amide/polyamine channel activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015204 name: urea transmembrane transporter activity namespace: molecular_function alt_id: GO:0015287 def: "Enables the transfer of urea from one side of a membrane to the other. Urea is the water soluble compound H2N-CO-NH2." [ISBN:0198506732] synonym: "urea transporter activity" BROAD [] xref: reactome:R-HSA-444126 "HUT2 and HUT11 mediate urea transport in kidney and erythrocytes respectively" xref: RHEA:32799 is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015205 name: nucleobase transmembrane transporter activity namespace: molecular_function alt_id: GO:0015392 def: "Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015207 name: adenine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of adenine, 6-aminopurine, from one side of a membrane to the other." [GOC:go_curators] xref: reactome:R-HSA-163215 "SLC25A5,6 dimers exchange ATP for ADP across the mitochondrial inner membrane" xref: reactome:R-HSA-5672027 "ARL2:GTP:ARL2BP:SLC25A4 dimer exchanges ATP for ADP across the mitochondrial inner membrane" is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity [Term] id: GO:0015208 name: guanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of guanine, 2-amino-6-hydroxypurine, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity [Term] id: GO:0015209 name: cytosine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cytosine, 4-amino-2-hydroxypyrimidine from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity [Term] id: GO:0015210 name: uracil transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uracil, 2,4-dioxopyrimidine, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" RELATED [] is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015211 name: purine nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleoside, a purine base covalently bonded to a ribose or deoxyribose sugar, from one side of a membrane to the other." [GOC:ai] is_a: GO:0005337 ! nucleoside transmembrane transporter activity [Term] id: GO:0015212 name: cytidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cytidine, cytosine riboside, from one side of a membrane to the other." [GOC:go_curators] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: GO:0015213 name: uridine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of uridine, uracil riboside, from one side of a membrane to the other." [GOC:go_curators] synonym: "uracil/uridine permease activity" NARROW [] is_a: GO:0015214 ! pyrimidine nucleoside transmembrane transporter activity [Term] id: GO:0015214 name: pyrimidine nucleoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar from one side of a membrane to the other." [GOC:ai] is_a: GO:0005337 ! nucleoside transmembrane transporter activity [Term] id: GO:0015215 name: nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, from one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0015932 ! nucleobase-containing compound transmembrane transporter activity [Term] id: GO:0015216 name: purine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0015217 name: ADP transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ADP, adenosine diphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity is_a: GO:0005346 ! purine ribonucleotide transmembrane transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity [Term] id: GO:0015218 name: pyrimidine nucleotide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0015219 name: obsolete protein-DNA complex transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of protein-DNA complexes from one side of a membrane to the other." [GOC:ai] comment: This term was obsoleted because there is no experimental evidence that this function exists. See https://github.com/geneontology/go-ontology/issues/17005 synonym: "DNA-protein complex transmembrane transporter activity" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0015220 name: choline transmembrane transporter activity namespace: molecular_function alt_id: GO:0005306 def: "Enables the transfer of choline from one side of a membrane to the other. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] synonym: "amino acid/choline transmembrane transporter activity" NARROW [] synonym: "choline permease activity" EXACT [] xref: reactome:R-HSA-429594 "SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol" xref: reactome:R-HSA-444433 "Cho transports from the extracellular space to the cytosol" xref: reactome:R-HSA-6797956 "SLC44A1 transports Cho from cytosol to mitochondrial matrix" is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity [Term] id: GO:0015221 name: lipopolysaccharide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "LPS transmembrane transporter activity" EXACT [] is_a: GO:0005319 ! lipid transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015223 name: obsolete vitamin or cofactor transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed transport of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "vitamin or cofactor transporter activity" EXACT [] synonym: "vitamin/cofactor transporter activity" EXACT [] is_obsolete: true consider: GO:0051184 consider: GO:0090482 [Term] id: GO:0015224 name: biopterin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of biopterin from one side of a membrane to the other. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [ISBN:0198506732] synonym: "biopterin transporter activity" RELATED [] is_a: GO:0051185 ! coenzyme transmembrane transporter activity [Term] id: GO:0015225 name: biotin transmembrane transporter activity namespace: molecular_function alt_id: GO:1901603 def: "Enables the transfer of biotin from one side of a membrane to the other. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "biotin transporter activity" RELATED [] synonym: "vitamin B7 transporter activity" RELATED [] synonym: "vitamin H transporter activity" RELATED [] xref: RHEA:28458 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015226 name: carnitine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carnitine across a membrane. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] synonym: "vitamin Bt transporter activity" EXACT [] xref: reactome:R-HSA-164967 "Unknown carnitine exporter transports CAR from the cytosol to the extracellular space" xref: reactome:R-HSA-165026 "OCTN2 / SLC22A5 transports CAR from extracellular space to cytosol" xref: reactome:R-HSA-549297 "SLC22A4, 5,15,16 cotransport CAR, Na+ from extracellular region to cytosol" is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015227 name: acyl carnitine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of acyl carnitine from one side of a membrane to the other. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [CHEBI:17387, GOC:ai] synonym: "acylcarnitine transporter activity" BROAD [] xref: reactome:R-HSA-200424 "Exchange of palmitoylcarnitine and carnitine across the inner mitochondrial membrane" is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015228 name: coenzyme A transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of coenzyme A from one side of a membrane to the other. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] synonym: "coenzyme A transporter activity" BROAD [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity [Term] id: GO:0015229 name: L-ascorbic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-ascorbate from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, ISBN:0198506732] synonym: "L-ascorbate transporter activity" EXACT [] synonym: "vitamin C transporter activity" EXACT [] xref: reactome:R-HSA-198870 "SVCT1/2 cotransports extracellular VitC and 2Na+ to cytosol" is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0015230 name: FAD transmembrane transporter activity namespace: molecular_function alt_id: GO:0005472 def: "Enables the directed movement of flavin-adenine dinucleotide (FAD) from one side of a membrane to the other. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] synonym: "FAD carrier activity" RELATED [] synonym: "FAD transporter activity" BROAD [] synonym: "flavin adenine dinucleotide carrier activity" RELATED [] synonym: "flavin adenine dinucleotide transmembrane transporter activity" EXACT [] synonym: "flavin-adenine dinucleotide carrier activity" RELATED [] synonym: "flavin-adenine dinucleotide transmembrane transporter activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity [Term] id: GO:0015231 name: 5-formyltetrahydrofolate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, from one side of a membrane to the other." [GOC:ai] synonym: "5-formyltetrahydrofolate transporter activity" EXACT [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015232 name: heme transporter activity namespace: molecular_function def: "Enables the directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells." [GOC:ai] synonym: "haem transporter activity" EXACT [] xref: reactome:R-HSA-1369065 "ABCB6 transports porphyrin from cytosol to mitchondrial matrix" xref: reactome:R-HSA-382560 "ABC7, mABC1 and mABC2 mediate heme transport" xref: reactome:R-HSA-917870 "SLC46A1 transports FeHM from extracellular region to cytosol" xref: reactome:R-HSA-917892 "FLVCR transports heme from cytosol to extracellular region" xref: reactome:R-HSA-917979 "ABCG2 dimer transports heme from cytosol to extracellular region" is_a: GO:0051184 ! cofactor transmembrane transporter activity [Term] id: GO:0015233 name: pantothenate transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of pantothenate across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate transporter activity" BROAD [GOC:mah] synonym: "vitamin B5 transmembrane transporter activity" EXACT [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0015234 name: thiamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015402 alt_id: GO:0015403 def: "Enables the transfer of thiamine from one side of a membrane to the other. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "thiamin permease activity" EXACT [] synonym: "thiamin transmembrane transporter activity" EXACT [GOC:curators] synonym: "thiamin uptake transporter activity" RELATED [GOC:curators] synonym: "thiamine permease activity" EXACT [] synonym: "thiamine uptake transmembrane transporter activity" RELATED [] synonym: "vitamin B1 transporter activity" EXACT [] xref: reactome:R-HSA-199626 "SLC19A2/3 transport extracellular THMN to cytosol" is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015238 name: drug transmembrane transporter activity namespace: molecular_function alt_id: GO:0015239 alt_id: GO:0015559 alt_id: GO:0015564 alt_id: GO:0090484 def: "Enables the transfer of a drug from one side of a membrane to the other. A drug is any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [ISBN:0198506732] subset: goslim_metagenomics synonym: "drug transporter activity" RELATED [] synonym: "multidrug efflux pump activity" RELATED [] synonym: "multidrug transporter activity" RELATED [] synonym: "multidrug, alkane resistant pump activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015240 name: amiloride transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of amiloride from one side of a membrane to the other. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [ISBN:0198506732] synonym: "amiloride transporter activity" RELATED [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015243 name: cycloheximide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cycloheximide from one side of a membrane to the other. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] synonym: "cycloheximide transporter activity" RELATED [] is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015244 name: fluconazole transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of fluconazole from one side of a membrane to the other. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators] synonym: "fluconazole transporter activity" RELATED [] is_a: GO:0015665 ! alcohol transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity [Term] id: GO:0015245 name: fatty acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015246 def: "Enables the transfer of fatty acids from one side of a membrane to the other. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732] synonym: "fatty acid transporter activity" RELATED [] synonym: "fatty acyl transporter activity" EXACT [GOC:curators] synonym: "fatty-acyl group transporter activity" BROAD [] synonym: "peroxisomal fatty acyl transporter" NARROW [] xref: reactome:R-HSA-879585 "SLC27A1,4,6 transport LCFAs from extracellular region to cytosol" is_a: GO:0005319 ! lipid transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity [Term] id: GO:0015247 name: aminophospholipid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of aminophospholipids from one side of a membrane to the other. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] synonym: "aminophospholipid transporter activity" RELATED [] is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity [Term] id: GO:0015248 name: sterol transporter activity namespace: molecular_function def: "Enables the directed movement of sterols into, out of or within a cell, or between cells. Sterol are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] xref: reactome:R-HSA-265783 "ABCG5:ABCG8 transports sterols from cytosol to extracellular region" xref: reactome:R-HSA-5250531 "ARV1 transports CHOL from ER membrane to plasma membrane" xref: reactome:R-HSA-8867667 "OSBPs transport 25OH-CHOL from ER membrane to plasma membrane" xref: reactome:R-HSA-8868402 "OSBP exchanges 25OH-CHOL with PI4P from ER membrane to Golgi membrane" is_a: GO:0005319 ! lipid transporter activity [Term] id: GO:0015250 name: water channel activity namespace: molecular_function def: "Transport systems of this type enable facilitated diffusion of water (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] synonym: "aquaporin" NARROW [] xref: reactome:R-HSA-432010 "Aquaporin-1 passively transports water into cell" xref: reactome:R-HSA-432054 "Aquaporin-1 passively transports water out of cell" xref: reactome:R-HSA-432065 "p-S256-Aquaporin-2 passively transports water into cell" xref: reactome:R-HSA-432067 "Aquaporin-4 passively transports water out of cell" xref: reactome:R-HSA-445714 "Aquaporin-3 passively transports water out of cell" xref: reactome:R-HSA-507868 "Aquaporins passively transport water into cells" xref: reactome:R-HSA-507870 "Aquaporins passively transport water out of cells" is_a: GO:0005372 ! water transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015251 name: ammonium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of ammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity is_a: GO:0008519 ! ammonium transmembrane transporter activity [Term] id: GO:0015252 name: proton channel activity namespace: molecular_function def: "Enables the facilitated diffusion of a hydrogen ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "hydrogen ion channel activity" EXACT [] is_a: GO:0005261 ! cation channel activity is_a: GO:0015078 ! proton transmembrane transporter activity [Term] id: GO:0015253 name: obsolete sugar/polyol channel activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. synonym: "sugar/polyol channel activity" EXACT [] is_obsolete: true consider: GO:0015166 consider: GO:0051119 [Term] id: GO:0015254 name: glycerol channel activity namespace: molecular_function def: "Enables the facilitated diffusion of glycerol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-432049 "Aquaporin-9 passively transports glycerol into cell" xref: reactome:R-HSA-432074 "Aquaporin-7 passively transports glycerol out of cell" xref: reactome:R-HSA-507869 "Aquaporins passively transport glycerol into cells" xref: reactome:R-HSA-507871 "Aquaporins passively transport glycerol out of cells" is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015255 name: propanediol channel activity namespace: molecular_function def: "Enables the facilitated diffusion of propanediol (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] is_a: GO:0015170 ! propanediol transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015256 name: obsolete monocarboxylate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "monocarboxylate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015257 name: obsolete organic anion channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "organic anion channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015258 name: obsolete gluconate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "gluconate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015259 name: obsolete glutamate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "glutamate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015260 name: obsolete isethionate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "isethionate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015261 name: obsolete lactate channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "lactate channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015262 name: obsolete taurine channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because this solute is transported by an active transporter rather than a channel. synonym: "taurine channel activity" EXACT [] is_obsolete: true [Term] id: GO:0015263 name: obsolete amine/amide/polyamine channel activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents three molecular functions. synonym: "amine/amide/polyamine channel activity" EXACT [] is_obsolete: true consider: GO:0005275 consider: GO:0015203 consider: GO:0042887 [Term] id: GO:0015264 name: methylammonium channel activity namespace: molecular_function def: "Enables the facilitated diffusion of methylammonium (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism. Methylammonium is CH3NH2." [GOC:mtg_transport, GOC:pr] is_a: GO:0015200 ! methylammonium transmembrane transporter activity is_a: GO:0015251 ! ammonium channel activity [Term] id: GO:0015265 name: urea channel activity namespace: molecular_function def: "Enables the facilitated diffusion of urea (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] xref: reactome:R-HSA-507873 "Aquaporins passively transport urea out of cells" xref: reactome:R-HSA-507875 "Aquaporins passively transport urea into cells" is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0015267 ! channel activity [Term] id: GO:0015267 name: channel activity namespace: molecular_function alt_id: GO:0015249 alt_id: GO:0015268 alt_id: GO:0022838 def: "Enables the energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel. Stereospecificity is not exhibited but this transport may be specific for a particular molecular species or class of molecules." [GOC:mtg_transport, ISBN:0815340729, TC:1.-.-.-.-] synonym: "alpha-type channel activity" RELATED [] synonym: "channel-forming toxin activity" RELATED [] synonym: "channel/pore class transporter activity" EXACT [] synonym: "nonselective channel activity" EXACT [] synonym: "pore activity" BROAD [] synonym: "pore class transporter activity" RELATED [] synonym: "substrate-specific channel activity" RELATED [] xref: reactome:R-HSA-3779381 "H2O2 diffuses from the mitochondrial matrix to the cytosol" xref: reactome:R-HSA-8953430 "PXMP2 trimer transports glycolate from cytosol to peroxisomal matrix" xref: TC:1 is_a: GO:0022803 ! passive transmembrane transporter activity [Term] id: GO:0015269 name: calcium-activated potassium channel activity namespace: molecular_function def: "Enables the calcium concentration-regulatable energy-independent passage of potassium ions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] is_a: GO:0005227 ! calcium activated cation channel activity is_a: GO:0005267 ! potassium channel activity [Term] id: GO:0015271 name: outward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel. An outwardly rectifying current-voltage relation is one where at any given driving force the outward flow of K+ ions exceeds the inward flow for the opposite driving force." [GOC:mah] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0015272 name: ATP-activated inward rectifier potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by ATP. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] xref: reactome:R-HSA-5683209 "Activating ABCC8 mutants cause hyperglycemia in permanent neonatal diabetes mellitus (PNDM) and transient neonatal DM (TNDM)." is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015274 name: organellar voltage-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. The membrane is an organellar membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "organellar voltage gated chloride channel activity" EXACT [] synonym: "organellar voltage-dependent chloride channel activity" EXACT [] is_a: GO:0005247 ! voltage-gated chloride channel activity [Term] id: GO:0015275 name: stretch-activated, cation-selective, calcium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching." [GOC:mtg_transport] is_a: GO:0005262 ! calcium channel activity is_a: GO:0140135 ! mechanosensitive cation channel activity [Term] id: GO:0015276 name: ligand-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic receptor activity" NARROW [GOC:bf, GOC:sart] xref: reactome:R-HSA-451310 "Activation of Edited Kainate receptors" xref: reactome:R-HSA-451311 "Activation of Ca-permeable Kainate receptors" xref: reactome:R-HSA-622325 "Activation of highly sodium permeable nicotinic acetylcholine receptors" xref: reactome:R-HSA-622326 "Activation of highly calcium permeable nicotinic acetylcholine receptors" xref: reactome:R-HSA-629595 "Activation of highly calcium permeable postsynaptic nicotinic acetylcholine receptors" is_a: GO:0005216 ! ion channel activity is_a: GO:0022834 ! ligand-gated channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0015277 name: kainate selective glutamate receptor activity namespace: molecular_function def: "An ionotropic glutamate receptor activity that exhibits fast gating by glutamate, acts by opening a cation channel permeable to sodium and potassium, and for which kainate is an agonist." [GOC:mah, PMID:10049997, PMID:8804111] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0005267 ! potassium channel activity is_a: GO:0005272 ! sodium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0015278 name: calcium-release channel activity namespace: molecular_function alt_id: GO:0005218 def: "Enables the transmembrane transfer of a calcium ion from intracellular stores by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "intracellular ligand-gated calcium channel activity" RELATED [GO:0015278] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0099604 ! ligand-gated calcium channel activity [Term] id: GO:0015279 name: store-operated calcium channel activity namespace: molecular_function def: "A ligand-gated ion channel activity which transports calcium in response to emptying of intracellular calcium stores." [GOC:dph, GOC:tb, PMID:15788710] xref: reactome:R-HSA-434798 "CRAC translocates calcium from the extracellular region to the cytosol" is_a: GO:0005262 ! calcium channel activity [Term] id: GO:0015280 name: ligand-gated sodium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a sodium ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mah] synonym: "acid-sensing ion channel activity" NARROW [GOC:fj] synonym: "amiloride-sensitive sodium channel activity" NARROW [GOC:fj] synonym: "ASIC activity" NARROW [GOC:fj] synonym: "epithelial sodium channel" NARROW [GOC:fj] xref: reactome:R-HSA-2672334 "SCNN channels transport extracellular Na+ to cytosol" is_a: GO:0005272 ! sodium channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0015282 name: obsolete NADPH oxidase-associated cytochrome b558 hydrogen channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it describes a gene product rather than a function. synonym: "NADPH oxidase-associated cytochrome b558 hydrogen channel activity" EXACT [] synonym: "NADPH oxidase-associated cytochrome b558 proton channel" EXACT [] is_obsolete: true [Term] id: GO:0015283 name: obsolete apoptogenic cytochrome c release channel activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a gene product. synonym: "apoptogenic cytochrome c release channel activity" EXACT [] synonym: "Bcl-2" NARROW [] is_obsolete: true [Term] id: GO:0015284 name: fructose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fructose(out) = fructose(in)." [TC:2.A.1.1.13] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015288 name: porin activity namespace: molecular_function def: "Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820, TC:1.B.1.-.-] synonym: "outer membrane exporter porin" NARROW [] synonym: "porin" EXACT [] xref: Wikipedia:Porin_(protein) is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0015289 name: obsolete pore-forming toxin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transport of electrolytes and other small molecules across a cell membrane. They are synthesized by one cell and secreted for insertion into the membrane of another cell where they form transmembrane pores. They may exert their toxic effects by allowing the free flow of electrolytes and other small molecules across the membrane, or they may allow entry into the target cell cytoplasm of a toxin protein that ultimately kills the cell." [PMID:10839820] comment: This term was made obsolete because it represents a class of gene products. synonym: "pore-forming toxin activity" EXACT [] is_obsolete: true consider: GO:0005198 consider: GO:0009405 consider: GO:0046930 consider: GO:0046931 consider: GO:0090729 [Term] id: GO:0015291 name: secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0015290 alt_id: GO:0015353 alt_id: GO:0015404 alt_id: GO:0015570 def: "Enables the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy, not direct ATP coupling. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729, PMID:10839820] synonym: "active transporter" BROAD [] synonym: "coupled carrier" EXACT [] synonym: "electrochemical potential-driven transporter activity" EXACT [] synonym: "energizer of outer membrane receptor-mediated transport activity" NARROW [] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] synonym: "heavy metal ion porter activity" NARROW [] synonym: "ion-gradient-driven energizer activity" NARROW [] synonym: "multidrug endosomal transmembrane transporter activity" NARROW [] synonym: "nitrite/nitrate porter activity" NARROW [] synonym: "porter activity" EXACT [] synonym: "porters" EXACT [] synonym: "secondary carrier-type facilitators" EXACT [] xref: reactome:R-HSA-199216 "SLC25A16 transports cytosolic CoA-SH to mitichondrial matrix" xref: TC:2.A is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015292 name: uniporter activity namespace: molecular_function def: "Catalysis of the transport of a single molecular species across a membrane; transport is independent of the movement of any other molecular species." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "facilitated diffusion carrier" EXACT [] synonym: "single-species transporter activity" EXACT [] synonym: "uniport" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015293 name: symporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "cotransporter activity" BROAD [] synonym: "porter activity" BROAD [] synonym: "symport" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015294 name: solute:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(out) = solute(in) + cation(in)." [GOC:ai] is_a: GO:0015293 ! symporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity [Term] id: GO:0015295 name: solute:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(out) = solute(in) + H+(in)." [GOC:ai] synonym: "heavy metal ion:hydrogen symporter activity" NARROW [] synonym: "high affinity metal ion uptake transporter activity" NARROW [] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] synonym: "low affinity metal ion uptake transporter activity" NARROW [] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] synonym: "solute:hydrogen symporter activity" EXACT [] is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015296 name: anion:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion(out) + cation(out) = anion(in) + cation(in)." [TC:2.A.1.14.-] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015297 name: antiporter activity namespace: molecular_function alt_id: GO:0015300 def: "Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. The reaction is: solute A(out) + solute B(in) = solute A(in) + solute B(out)." [GOC:mtg_transport, ISBN:0815340729, PMID:10839820] synonym: "antiport" RELATED [] synonym: "countertransporter activity" EXACT [] synonym: "exchange transporter activity" EXACT [] synonym: "exchanger" BROAD [] synonym: "porter" BROAD [] synonym: "solute:solute antiporter activity" EXACT [] synonym: "solute:solute exchange" RELATED [] xref: reactome:R-HSA-2730692 "CLCN4/5/6 exchange Cl- for H+" xref: reactome:R-HSA-2730959 "CLCN7:OSTM1 exchanges Cl- for H+" xref: reactome:R-HSA-2731002 "CLCN3 exchanges Cl- for H+" is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015298 name: solute:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + cation(in) = solute(in) + cation(out)." [GOC:ai] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0015299 name: solute:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + H+(in) = solute(in) + H+(out)." [GOC:ai] synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" NARROW [] synonym: "solute:hydrogen antiporter activity" EXACT [] is_a: GO:0015078 ! proton transmembrane transporter activity is_a: GO:0015298 ! solute:cation antiporter activity [Term] id: GO:0015301 name: anion:anion antiporter activity namespace: molecular_function alt_id: GO:0015380 alt_id: GO:0015384 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: anion A(out) + anion B(in) = anion A(in) + anion B(out)." [GOC:ai, GOC:mtg_transport] synonym: "anion exchanger activity" EXACT [] synonym: "bicarbonate:chloride antiporter" NARROW [] xref: reactome:R-HSA-561041 "OAT1-3 transport organic anions with antiport of dicarboxylic acids" is_a: GO:0008509 ! anion transmembrane transporter activity is_a: GO:0099516 ! ion antiporter activity [Term] id: GO:0015303 name: obsolete galactose, glucose uniporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: galactose or glucose(out) = galactose or glucose(in)." [TC:2.A.1.1.6] comment: This term was made obsolete because it represents two molecular functions. synonym: "galactose, glucose uniporter activity" EXACT [] is_obsolete: true consider: GO:0015304 consider: GO:0050782 [Term] id: GO:0015304 name: glucose uniporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) = glucose(in)." [TC:2.A.1.1.12, TC:2.A.1.1.4, TC:2.A.1.1.6] synonym: "galactose, glucose uniporter activity" NARROW [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008516 ! hexose uniporter activity [Term] id: GO:0015305 name: obsolete lactose, galactose:proton symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (lactose or galactose)(out) + H+(out) = (lactose or galactose)(in) + H+(in)." [TC:2.A.1.1.9] comment: This term was made obsolete because it represents two molecular functions. synonym: "lactose, galactose:hydrogen symporter activity" EXACT [] synonym: "lactose, galactose:proton symporter activity" EXACT [] synonym: "lactose,galactose:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015517 consider: GO:0015528 [Term] id: GO:0015306 name: sialate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + cation(out) = sialate(in) + cation(in)." [TC:2.A.1.14.10] synonym: "cation/sialate symporter activity" EXACT [] synonym: "cation:sialate symporter activity" EXACT [] synonym: "sialate transporter activity" BROAD [] synonym: "sialate/cation symporter activity" EXACT [] is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015307 name: drug:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + drug(in) = H+(in) + drug(out)." [TC:2.A.1.2.-, TC:2.A.1.3.-] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "drug:hydrogen antiporter activity" EXACT [] xref: reactome:R-HSA-434650 "MATEs mediate extrusion of xenobiotics" xref: reactome:R-HSA-597628 "SLC22A18 exchanges extracellular organic cations for cytosolic H+" is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015308 name: amiloride:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + amiloride(in) = H+(in) + amiloride(out)." [TC:2.A.1.2.1] synonym: "amiloride:hydrogen antiporter activity" EXACT [] is_a: GO:0015240 ! amiloride transmembrane transporter activity is_a: GO:0015307 ! drug:proton antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0015309 name: cycloheximide:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + cycloheximide(in) = H+(in) + cycloheximide(out)." [TC:2.A.1.2.2] synonym: "cycloheximide:hydrogen antiporter activity" EXACT [] is_a: GO:0015243 ! cycloheximide transmembrane transporter activity is_a: GO:0015307 ! drug:proton antiporter activity [Term] id: GO:0015310 name: benomyl:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + benomyl(in) = H+(in) + benomyl(out)." [TC:2.A.1.2.6] synonym: "benomyl:hydrogen antiporter activity" EXACT [] is_a: GO:0015307 ! drug:proton antiporter activity is_a: GO:1901479 ! benomyl transmembrane transporter activity [Term] id: GO:0015311 name: monoamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + monoamine(in) = H+(in) + monoamine(out)." [TC:2.A.1.2.11, TC:2.A.1.2.12] synonym: "monoamine:hydrogen antiporter activity" EXACT [] is_a: GO:0008504 ! monoamine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015312 name: polyamine:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + polyamine(in) = H+(in) + polyamine(out)." [TC:2.A.1.2.16] synonym: "polyamine:hydrogen antiporter activity" EXACT [] is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0015299 ! solute:proton antiporter activity [Term] id: GO:0015313 name: fluconazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + fluconazole(in) = H+(in) + fluconazole(out)." [TC:2.A.1.2.17] synonym: "fluconazole:hydrogen antiporter activity" EXACT [] is_a: GO:0015244 ! fluconazole transmembrane transporter activity is_a: GO:0045119 ! azole:proton antiporter activity [Term] id: GO:0015314 name: aminotriazole:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + aminotriazole(in) = H+(in) + aminotriazole(out)." [TC:2.A.1.3.1] synonym: "aminotriazole:hydrogen antiporter activity" EXACT [] is_a: GO:0045119 ! azole:proton antiporter activity [Term] id: GO:0015315 name: organophosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organophosphate(out) + inorganic phosphate(in) = organophosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.-] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015316 name: obsolete nitrite/nitrate porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "nitrite/nitrate porter activity" EXACT [] is_obsolete: true consider: GO:0015112 consider: GO:0015113 consider: GO:0015291 [Term] id: GO:0015317 name: phosphate:proton symporter activity namespace: molecular_function alt_id: GO:0015320 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phosphate(out) + H+(out) = phosphate(in) + H+(in)." [TC:2.A.1.9.-] comment: Merge phosphate ion carrier activity and phosphate:proton symporter activity, https://github.com/geneontology/go-ontology/issues/14221 synonym: "phosphate ion carrier activity" EXACT [] synonym: "phosphate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015318 name: inorganic molecular entity transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an inorganic molecular entity from the outside of a cell to the inside of the cell across a membrane. An inorganic molecular entity is a molecular entity that contains no carbon." [GOC:mtg_transport, ISBN:0815340729] comment: Renamed term see https://github.com/geneontology/go-ontology/issues/14372 subset: gocheck_do_not_annotate synonym: "inorganic solute uptake transmembrane transporter activity" EXACT [] synonym: "inorganic uptake permease activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015319 name: sodium:inorganic phosphate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + inorganic phosphate(out) = Na+(in) + inorganic phosphate(in)." [TC:2.A.1.14.6] is_a: GO:0005315 ! inorganic phosphate transmembrane transporter activity is_a: GO:0005436 ! sodium:phosphate symporter activity [Term] id: GO:0015321 name: sodium-dependent phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphate (PO4 3-) ions from one side of a membrane to the other, requiring sodium ions." [GOC:jl] xref: reactome:R-HSA-427605 "SLC20A1,2 cotransport Pi, Na+ from extracellular region to cytosol" xref: reactome:R-HSA-427645 "SLC34A3 cotransports Pi, 2Na+" xref: reactome:R-HSA-427656 "SLC34A1,2 cotransports HPO4(2-), 3Na+ from extracellular region to cytosol" xref: reactome:R-HSA-428609 "Type I Na+-coupled phosphate co-transport" is_a: GO:0015114 ! phosphate ion transmembrane transporter activity [Term] id: GO:0015322 name: secondary active oligopeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an oligopeptide or oligopeptides from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "oligopeptide porter activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015323 name: obsolete type V protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type V protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015324 name: peptide-acetyl-CoA secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptide-acetyl-CoA from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "peptide-acetyl-CoA transporter activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015325 name: acetyl-CoA:CoA antiporter activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA(out) + CoA(in) = acetyl-CoA(in) + CoA(out)." [TC:2.A.1.25.1] is_a: GO:0008521 ! acetyl-CoA transmembrane transporter activity is_a: GO:0015297 ! antiporter activity is_a: GO:0015324 ! peptide-acetyl-CoA secondary active transmembrane transporter activity [Term] id: GO:0015327 name: cystine:glutamate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cystine(out) + glutamate(in) = cystine(in) + glutamate(out)." [TC:2.A.3.8.5] is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015328 ! cystine secondary active transmembrane transporter activity [Term] id: GO:0015328 name: cystine secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cystine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "cystine porter activity" RELATED [] synonym: "cystinosin" NARROW [] synonym: "lysosomal cystine transporter" NARROW [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:1901680 ! sulfur-containing amino acid secondary active transmembrane transporter activity [Term] id: GO:0015330 name: high-affinity glutamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of glutamine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity glutamine permease activity" RELATED [] synonym: "high affinity glutamine transmembrane transporter activity" EXACT [] is_a: GO:0005287 ! high-affinity basic amino acid transmembrane transporter activity is_a: GO:0015186 ! L-glutamine transmembrane transporter activity [Term] id: GO:0015331 name: obsolete asparagine/glutamine permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the stereospecific transfer of asparagine or glutamine across a biological membrane." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "asparagine/glutamine permease activity" EXACT [] is_obsolete: true consider: GO:0015182 consider: GO:0015186 consider: GO:0022857 [Term] id: GO:0015332 name: obsolete leucine/valine/isoleucine permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "leucine/valine/isoleucine permease activity" EXACT [] is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0022857 [Term] id: GO:0015333 name: peptide:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: peptide(out) + H+(out) = peptide(in) + H+(in), up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by hydrogen ion movement." [GOC:mtg_transport, TC:2.A.17.-.-] synonym: "peptide:hydrogen symporter activity" EXACT [] xref: reactome:R-HSA-427998 "Proton-coupled di- and tri-peptide cotransport" xref: reactome:R-HSA-428007 "Proton-coupled histidine and di-peptide cotransport" is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity [Term] id: GO:0015334 name: high-affinity oligopeptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oligopeptide from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [GOC:mtg_transport] synonym: "high affinity oligopeptide transporter activity" EXACT [] synonym: "high-affinity oligopeptide transporter activity" RELATED [] is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015335 name: obsolete heavy metal ion:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in), where Me2+ is Fe2+, Zn2+, Mn2+, Cu2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:2.A.55.2.1, TC:2.A.55.2.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "heavy metal ion:hydrogen symporter activity" EXACT [] synonym: "heavy metal ion:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015336 name: obsolete high affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Fe2+, Mn2+, Zn2+, Cu2+, Cd2+, Ni2+ or Co2+." [TC:2.A.55.1.1] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "high affinity metal ion uptake transporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015337 name: obsolete low affinity metal ion uptake transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(out) + H+(out) = Me2+(in) + H+(in). Me can be Mn2+ or Cu2+." [TC:2.A.55.1.2] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "low affinity metal ion uptake transporter activity" EXACT [] is_obsolete: true consider: GO:0015295 consider: GO:0046873 [Term] id: GO:0015339 name: obsolete cobalt, zinc uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Co2+)(out) = (Zn2+ or Co2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.1] comment: This term was made obsolete because it represents more than one molecular function. synonym: "cobalt, zinc uptake permease activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015087 [Term] id: GO:0015340 name: obsolete zinc, cadmium uptake permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Cd2+)(out) = (Zn2+ or Cd2+)(in). The activity is driven by proton motive force, possibly by proton symport." [TC:2.A.4.2.2] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, cadmium uptake permease activity" EXACT [] is_obsolete: true consider: GO:0005385 consider: GO:0015086 [Term] id: GO:0015341 name: zinc efflux active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane: Zn2+(out) = Zn2+(in). The activity is driven by proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.4.1.4, TC:2.A.4.2.3] synonym: "zinc efflux permease activity" BROAD [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0022883 ! zinc efflux transmembrane transporter activity [Term] id: GO:0015342 name: obsolete zinc, iron permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (Zn2+ or Fe2+)(out) = (Zn2+ or Fe2+)(in), probably powered by proton motive force." [TC:2.A.5.-.-] comment: This term was made obsolete because it represents more than one molecular function. synonym: "zinc, iron permease activity" EXACT [] is_obsolete: true consider: GO:0005381 consider: GO:0005385 [Term] id: GO:0015343 name: siderophore transmembrane transporter activity namespace: molecular_function alt_id: GO:0015236 alt_id: GO:0015237 alt_id: GO:0042927 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in)." [TC:2.A.1.16.-] synonym: "iron-siderophore transporter activity" EXACT [] synonym: "siderochrome transporter activity" NARROW [] synonym: "siderochrome-iron transporter activity" NARROW [] synonym: "siderophore transporter activity" RELATED [] synonym: "siderophore-iron transmembrane transporter activity" RELATED [] synonym: "siderophore-iron transporter activity" RELATED [] xref: reactome:R-HSA-1222597 "Loaded mycobactin gets imported" is_a: GO:0051184 ! cofactor transmembrane transporter activity [Term] id: GO:0015344 name: siderophore uptake transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(ferrioxamine)(out) + H+(out) = siderophore-iron(ferrioxamine)(in) + H+(in)." [TC:2.A.1.16.1] synonym: "ferrioxamine uptake transmembrane transporter activity" RELATED [] synonym: "siderochrome-iron (ferrioxamine) uptake transporter" NARROW [] synonym: "siderophore-iron uptake transmembrane transporter activity" RELATED [] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015345 name: ferric enterobactin:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric enterobactin(out) + H+(out) = ferric enterobactin(in) + H+(in)." [TC:2.A.1.16.2] synonym: "ferric enterobactin:hydrogen symporter activity" EXACT [] synonym: "ferric-enterobactin:proton symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:0042931 ! enterobactin transmembrane transporter activity [Term] id: GO:0015346 name: ferric triacetylfusarinine C:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ferric triacetylfusarinine C(out) + H+(out) = ferric triacetylfusarinine C(in) + H+(in)." [TC:2.A.1.16.3] synonym: "ferric triacetylfusarinine C:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015621 ! ferric triacetylfusarinine C transmembrane transporter activity [Term] id: GO:0015347 name: sodium-independent organic anion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organic anions from one side of a membrane to the other, in a sodium independent manner." [GOC:go_curators] xref: reactome:R-HSA-561059 "OAT2 and OAT4 mediate transport of sulphate conjugates" xref: reactome:R-HSA-879562 "SLCO2B1 has a narrow substrate specificity" xref: reactome:R-HSA-879584 "SLCO3A1 isoform 1 has abroad substrate specificity" xref: reactome:R-HSA-879594 "SLCO4C1 mediates the transport of digoxin" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015348 name: obsolete prostaglandin/thromboxane transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "prostaglandin/thromboxane transporter activity" EXACT [] is_obsolete: true consider: GO:0008028 consider: GO:0015132 [Term] id: GO:0015349 name: thyroid hormone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of thyroid hormones from one side of a membrane to the other. Thyroid hormone are any of the compounds secreted by the thyroid gland, largely thyroxine and triiodothyronine." [GOC:ai] xref: reactome:R-HSA-879575 "SLCOs, SLC16A2 transport T3,T4 from extracellular region to cytosol" is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015350 name: methotrexate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of methotrexate, 4-amino-10-methylformic acid from one side of a membrane to the other. Methotrexate is a folic acid analogue and a potent competitive inhibitor of dihydrofolate reductase." [GOC:ai] synonym: "methotrexate transporter activity" RELATED [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity [Term] id: GO:0015351 name: bilirubin secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bilirubin from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters." [GOC:mtg_transport] synonym: "bilirubin porter activity" RELATED [] synonym: "bilitranslocase" NARROW [] is_a: GO:0015127 ! bilirubin transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015352 name: secondary active sterol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sterol from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport] synonym: "sterol porter activity" RELATED [] is_a: GO:0015248 ! sterol transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015355 name: secondary active monocarboxylate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the movement of a monocarboxylate, any compound containing a single carboxyl group (COOH or COO-), by uniport, symport or antiport across a membrane by a carrier-mediated mechanism." [GOC:bf, GOC:jl] synonym: "monocarboxylate porter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015356 name: obsolete monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" EXACT [] is_obsolete: true consider: GO:0015129 consider: GO:0015130 consider: GO:0015562 consider: GO:0050833 [Term] id: GO:0015358 name: obsolete amino acid/choline transmembrane transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "amino acid/choline transmembrane transporter activity" EXACT [] is_obsolete: true consider: GO:0015171 consider: GO:0015220 [Term] id: GO:0015360 name: acetate:proton symporter activity namespace: molecular_function alt_id: GO:0015357 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: acetate(out) + H+(out) = acetate(in) + H+(in)." [TC:2.A.44.4.1] synonym: "acetate:hydrogen symporter activity" EXACT [] synonym: "hydrogen:acetate symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0043893 ! acetate:cation symporter activity [Term] id: GO:0015361 name: low-affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.47.1.1] synonym: "low affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "low affinity sodium:dicarboxylate symporter activity" EXACT [] xref: reactome:R-HSA-433131 "NaDC1 co-transports dicarboxylic acids and a sodium ion" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015362 name: high-affinity sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in). In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.47.1.4] synonym: "high affinity sodium:dicarboxylate cotransporter activity" BROAD [] synonym: "high affinity sodium:dicarboxylate symporter activity" EXACT [] xref: reactome:R-HSA-433101 "NaDC3 co-transports the dicarboxylic acid succinate and three sodium ion" is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015363 name: obsolete dicarboxylate (succinate/fumarate/malate) antiporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" EXACT [] is_obsolete: true consider: GO:0005310 consider: GO:0015138 consider: GO:0015140 consider: GO:0015141 consider: GO:0015297 [Term] id: GO:0015364 name: dicarboxylate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + inorganic phosphate(in) = dicarboxylate(in) + inorganic phosphate(out)." [TC:2.A.29.2.3] is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0015366 name: malate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: malate(out) + H+(out) = malate(in) + H+(in)." [TC:2.A.16.2.1] synonym: "L-malic acid permease" RELATED [GOC:vw] synonym: "L-malic acid:proton symporter activity" RELATED [GOC:vw] synonym: "malate permease" RELATED [GOC:vw] synonym: "malate:hydrogen symporter activity" EXACT [] is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015367 name: oxoglutarate:malate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: oxoglutarate(out) + malate(in) = oxoglutarate(in) + malate(out)." [TC:2.A.29.2.1] synonym: "2-oxoglutarate/malate carrier protein" EXACT [Wikipedia:Mitochondrial_carrier] xref: reactome:R-HSA-198440 "malate [mitochondrial matrix] + alpha-ketoglutarate [cytosol] <=> malate [cytosol] + alpha-ketoglutarate [mitochondrial matrix]" xref: reactome:R-HSA-376851 "Exchange of alpha-ketoglutarate (2-oxoglutarate) and malate across the inner mitochondrial membrane" is_a: GO:0015140 ! malate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015368 name: calcium:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + cation(out) = Ca2+(out) + cation(in)." [TC:2.A.19.-.-] xref: reactome:R-HSA-425822 "K+-independent Li+/Ca2+ exchanger transport" is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0015369 name: calcium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + H+(out) = Ca2+(out) + H+(in)." [TC:2.A.19.2.-] synonym: "calcium:hydrogen antiporter activity" EXACT [] xref: reactome:R-HSA-8949687 "LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)" xref: RHEA:29671 is_a: GO:0015368 ! calcium:cation antiporter activity is_a: GO:0051139 ! metal ion:proton antiporter activity [Term] id: GO:0015370 name: solute:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: solute(out) + Na+(out) = solute(in) + Na+(in)." [GOC:ai] synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" NARROW [] xref: reactome:R-HSA-8876283 "SLC5A10 cotransports Na+ with Man, Fru from extracellular region to cytosol" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015371 name: galactose:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015372 name: obsolete glutamate/aspartate:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (glutamate or aspartate)(out) + Na+(out) = (glutamate or aspartate)(in) + Na+(in)." [TC:2.A.23.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glutamate/aspartate:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0005313 consider: GO:0015183 [Term] id: GO:0015373 name: anion:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent anion(out) + Na+(out) = monovalent anion(in) + Na+(in)." [TC:2.A.21.5.-] synonym: "monovalent anion:sodium symporter activity" EXACT [] is_a: GO:0015296 ! anion:cation symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015374 name: neutral, basic amino acid:sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral/basic amino acid(out) + Na+(out) + Cl-(out) = neutral/basic amino acid(in) + Na+(in) + Cl-(in)." [TC:2.A.22.2.3] synonym: "neutral, cationic amino acid:sodium:chloride symporter activity" RELATED [] is_a: GO:0005283 ! amino acid:sodium symporter activity [Term] id: GO:0015375 name: glycine:sodium symporter activity namespace: molecular_function alt_id: GO:0015656 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine(out) + Na+(out) = glycine(in) + Na+(in)." [GOC:ai] xref: reactome:R-HSA-444120 "SLC6A5,9 cotransport Gly, Cl-, Na+ from extracellular region to cytosol" is_a: GO:0005295 ! neutral amino acid:sodium symporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0015187 ! glycine transmembrane transporter activity [Term] id: GO:0015376 name: obsolete betaine/GABA:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (betaine or gamma-aminobutyric acid)(out) + Na+(out) = (betaine or gamma-aminobutyric acid)(in) + Na+(in)." [TC:2.A.22.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "betaine/GABA:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005332 consider: GO:0015185 consider: GO:0015199 consider: GO:0015370 [Term] id: GO:0015377 name: cation:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation(out) + Cl-(out) = cation(in) + Cl-(in)." [TC:2.A.30.-.-] synonym: "cation:chloride cotransporter activity" BROAD [] is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0015378 name: sodium:chloride symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + Cl-(out) = Na+(in) + Cl-(in)." [TC:2.A.30.4.-] xref: reactome:R-HSA-426130 "SLC12A3 cotransports Cl-, Na+ from extracellular region to cytosol" is_a: GO:0015373 ! anion:sodium symporter activity is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015379 name: potassium:chloride symporter activity namespace: molecular_function alt_id: GO:0022820 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Cl-(out) = K+(in) + Cl-(in)." [TC:2.A.30.5.-] synonym: "potassium ion symporter activity" BROAD [] xref: reactome:R-HSA-426155 "SLC12A4,5,6,7 cotransport K+, Cl- from cytosol to extracellular region" is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0015381 name: high-affinity sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the secondary active high affinity transfer of sulfate from one side of a membrane to the other. Secondary active transport is the transfer of a solute across a membrane, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind thesolute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity sulfate permease activity" RELATED [] synonym: "high affinity sulfate transmembrane transporter activity" EXACT [] synonym: "high affinity sulphate permease activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity [Term] id: GO:0015382 name: sodium:sulfate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + Na+(out) = sulfate(in) + Na+(in)." [TC:2.A.47.1.2] synonym: "sodium:sulfate cotransporter activity" BROAD [] synonym: "sodium:sulphate symporter activity" EXACT [] xref: reactome:R-HSA-433099 "NaS2 co-transports sulphate and two sodium ions" xref: reactome:R-HSA-433114 "NaS1 co-transports sulphate and a sodium ion" is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015373 ! anion:sodium symporter activity [Term] id: GO:0015383 name: sulfate:bicarbonate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + bicarbonate(in) = sulfate(in) + bicarbonate(out)." [TC:2.A.53.2.2] synonym: "sulphate:bicarbonate antiporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity [Term] id: GO:0015385 name: sodium:proton antiporter activity namespace: molecular_function alt_id: GO:0015502 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [TC:2.A.35.1.1, TC:2.A.36.-.-] synonym: "pH-dependent sodium:hydrogen antiporter activity" NARROW [] synonym: "pH-dependent sodium:proton antiporter activity" NARROW [] synonym: "sodium/hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen antiporter activity" EXACT [] synonym: "sodium:hydrogen exchange activity" EXACT [] synonym: "sodium:hydrogen exchanger" EXACT [] xref: reactome:R-HSA-2872444 "SLC9B1/C2 exchange Na+ for H+" xref: reactome:R-HSA-2872463 "SLC9C1 exchanges Na+ for H+" xref: reactome:R-HSA-425965 "SLC9A9 exchanges Na+ for H+ across the late endosome membrane" xref: reactome:R-HSA-425983 "SLC9A6,7 exchange Na+ for H+ across the early endosome membrane" xref: reactome:R-HSA-425994 "Na+/H+ exchanger transport (at cell membrane)" xref: reactome:R-HSA-426015 "Na+/H+ exchanger transport (at trans-golgi membrane)" xref: RHEA:29251 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity [Term] id: GO:0015386 name: potassium:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in)." [TC:2.A.37.-.-] synonym: "potassium:hydrogen antiporter activity" EXACT [] xref: RHEA:29467 is_a: GO:0005451 ! monovalent cation:proton antiporter activity is_a: GO:0022821 ! potassium ion antiporter activity [Term] id: GO:0015387 name: potassium:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + H+(out) = K+(in) + H+(in)." [TC:2.A.38.-.-] synonym: "potassium:hydrogen symporter activity" EXACT [] xref: RHEA:28490 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015389 name: pyrimidine- and adenine-specific:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (pyrimidine nucleoside or adenine)(out) + Na+(out) = (pyrimidine nucleoside or adenine)(in) + Na+(in)." [TC:2.A.41.2.3] is_a: GO:0005345 ! purine nucleobase transmembrane transporter activity is_a: GO:0005350 ! pyrimidine nucleobase transmembrane transporter activity is_a: GO:0005415 ! nucleoside:sodium symporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015390 name: purine-specific nucleoside:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: purine(out) + Na+(out) = nucleoside(in) + Na+(in)." [TC:2.A.41.2.1] is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015391 name: nucleobase:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleobase(out) + cation(out) = nucleobase(in) + cation(in)." [GOC:ai] is_a: GO:0015205 ! nucleobase transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0015393 name: obsolete uracil/uridine permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "uracil/uridine permease activity" EXACT [] is_obsolete: true consider: GO:0015210 consider: GO:0015213 consider: GO:0022857 [Term] id: GO:0015394 name: uridine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uridine(out) + H+(out) = uridine(in) + H+(in)." [GOC:mtg_transport] synonym: "nucleoside (uridine) permease activity" RELATED [] synonym: "uridine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015213 ! uridine transmembrane transporter activity is_a: GO:0015506 ! nucleoside:proton symporter activity [Term] id: GO:0015395 name: nucleoside transmembrane transporter activity, down a concentration gradient namespace: molecular_function alt_id: GO:0015396 alt_id: GO:0015397 def: "Enables the transfer of a nucleoside, from one side of a membrane to the other, down the concentration gradient." [PMID:10353709, PMID:11749958, PMID:12446811] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-insensitive activity" NARROW [] synonym: "equilibrative nucleoside transmembrane transporter, nitrobenzyl-thioinosine-sensitive activity" NARROW [] synonym: "equilibrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015398 name: high-affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity secondary active ammonium transmembrane transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015399 name: primary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute from one side of a membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is powered by a primary energy source, directly using ATP. Primary energy sources known to be coupled to transport are chemical, electrical and solar sources." [GOC:mtg_transport, ISBN:0815340729, TC:3.-.-.-.-] synonym: "primary active transporter" RELATED [] xref: TC:3 is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015400 name: low-affinity secondary active ammonium transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ammonium from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low affinity ammonium transmembrane transporter activity" RELATED [] synonym: "low affinity secondary active ammonium transmembrane transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015401 name: urea:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: urea(out) + Na+(out) = urea(in) + Na+(in)." [TC:2.A.21.6.1] synonym: "urea active transmembrane transporter activity" EXACT [] is_a: GO:0015204 ! urea transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0015405 name: P-P-bond-hydrolysis-driven transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.-.-.-] synonym: "P-P-bond-hydrolysis-driven transporters" EXACT [] xref: TC:3.A is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015406 name: obsolete ABC-type uptake permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type uptake permease activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015407 name: monosaccharide-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + monosaccharide(out) = ADP + phosphate + monosaccharide(in). Ribose, xylose, arabinose, galactose and methylgalactoside are imported." [EC:3.6.3.17] synonym: "ATP phosphohydrolase (monosaccharide-importing)" EXACT [EC:3.6.3.17] synonym: "monosaccharide ABC transporter" NARROW [] synonym: "monosaccharide-importing ATPase activity" NARROW [] xref: EC:3.6.3.17 xref: MetaCyc:3.6.3.17-RXN xref: RHEA:29900 is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0015408 name: ferric-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Fe3+(out) = ADP + phosphate + Fe3+(in)." [EC:3.6.3.30] synonym: "ATP phosphohydrolase (ferric-ion-transporting)" EXACT [EC:3.6.3.30] synonym: "Fe3+-transporting ATPase activity" EXACT [EC:3.6.3.30] synonym: "ferric ABC transporter" NARROW [] synonym: "ferric transporting ATPase activity" EXACT [] xref: EC:3.6.3.30 xref: MetaCyc:3.6.3.30-RXN xref: RHEA:12332 is_a: GO:0015091 ! ferric iron transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015410 name: manganese-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mn2+(out) = ADP + phosphate + Mn2+(in)." [EC:3.6.3.35] synonym: "ABC-type manganese permease complex" RELATED [EC:3.6.3.35] synonym: "ATP phosphohydrolase (manganese-importing)" EXACT [EC:3.6.3.35] synonym: "manganese ABC transporter" NARROW [] synonym: "manganese transporting ATPase activity" EXACT [] xref: EC:3.6.3.35 xref: MetaCyc:3.6.3.35-RXN xref: reactome:R-HSA-5692462 "ATP13A1 transports Mn2+ from cytosol to ER lumen" xref: RHEA:17365 is_a: GO:0005384 ! manganese ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015411 name: taurine-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + taurine(out) = ADP + phosphate + taurine(in)." [EC:3.6.3.36] synonym: "ATP phosphohydrolase (taurine-importing)" EXACT [EC:3.6.3.36] synonym: "taurine (2-aminoethane sulfonate) porter activity" EXACT [] synonym: "taurine ABC transporter" NARROW [] xref: EC:3.6.3.36 xref: MetaCyc:3.6.3.36-RXN xref: RHEA:14614 is_a: GO:0005368 ! taurine transmembrane transporter activity is_a: GO:0008559 ! xenobiotic transmembrane transporting ATPase activity is_a: GO:0033283 ! organic acid-transporting ATPase activity [Term] id: GO:0015412 name: ATPase-coupled molybdate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + molybdate(out) = ADP + phosphate + molybdate(in)." [EC:3.6.3.29] synonym: "ATP phosphohydrolase (molybdate-importing)" EXACT [EC:3.6.3.29] synonym: "molybdate ABC transporter" NARROW [] synonym: "molybdate porter activity" EXACT [] synonym: "molybdate transmembrane-transporting ATPase activity" RELATED [] synonym: "molybdate transporting ATPase activity" EXACT [] synonym: "molybdate-transporting ATPase activity" EXACT [EC:3.6.3.29] xref: EC:3.6.3.29 xref: MetaCyc:3.6.3.29-RXN xref: RHEA:22020 is_a: GO:0015098 ! molybdate ion transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0015413 name: nickel-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ni2+(out) = ADP + phosphate + Ni2+(in)." [EC:3.6.3.24] synonym: "ATP phosphohydrolase (nickel-importing)" EXACT [EC:3.6.3.24] synonym: "nickel ABC transporter" NARROW [] synonym: "nickel porter activity" EXACT [] synonym: "nickel transporting ATPase activity" EXACT [] xref: EC:3.6.3.24 xref: MetaCyc:3.6.3.24-RXN xref: RHEA:15557 is_a: GO:0015099 ! nickel cation transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity is_a: GO:0072509 ! divalent inorganic cation transmembrane transporter activity [Term] id: GO:0015414 name: ATPase-coupled nitrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nitrate(out) = ADP + phosphate + nitrate(in)." [EC:3.6.3.26] synonym: "ATP phosphohydrolase (nitrate-importing)" EXACT [EC:3.6.3.26] synonym: "nitrate ABC transporter" NARROW [] synonym: "nitrate transmembrane-transporting ATPase activity" RELATED [] synonym: "nitrate transporting ATPase activity" EXACT [] synonym: "nitrate-transporting ATPase activity" EXACT [EC:3.6.3.26] xref: EC:3.6.3.26 xref: MetaCyc:3.6.3.26-RXN xref: RHEA:13181 is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0015415 name: ATPase-coupled phosphate ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphate(out) = ADP + phosphate + phosphate(in)." [EC:3.6.3.27] synonym: "ABC phosphate transporter activity" NARROW [EC:3.6.3.27] synonym: "ATP phosphohydrolase (phosphate-importing)" EXACT [EC:3.6.3.27] synonym: "phosphate ABC transporter" NARROW [] synonym: "phosphate ion transmembrane-transporting ATPase activity" RELATED [] synonym: "phosphate porter activity" EXACT [] synonym: "phosphate transporting ATPase activity" EXACT [] synonym: "phosphate-transporting ATPase activity" EXACT [EC:3.6.3.27] xref: EC:3.6.3.27 xref: MetaCyc:3.6.3.27-RXN xref: RHEA:24440 is_a: GO:0015114 ! phosphate ion transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0015416 name: ATPase-coupled organic phosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [EC:3.6.3.28] synonym: "ATP phosphohydrolase (phosphonate-transporting)" EXACT [EC:3.6.3.28] synonym: "organic phosphonate transmembrane-transporting ATPase activity" RELATED [] synonym: "phosphonate ABC transporter" NARROW [] synonym: "phosphonate transporting ATPase activity" EXACT [] synonym: "phosphonate-transporting ATPase activity" EXACT [EC:3.6.3.28] xref: EC:3.6.3.28 xref: MetaCyc:3.6.3.28-RXN xref: RHEA:18065 is_a: GO:0015604 ! organic phosphonate transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0015417 name: polyamine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + polyamine(out) = ADP + phosphate + polyamine(in)." [EC:3.6.3.31] synonym: "ATP phosphohydrolase (polyamine-importing) activity" EXACT [EC:3.6.3.31] synonym: "polyamine ABC transporter" NARROW [] synonym: "polyamine porter activity" EXACT [] synonym: "polyamine-importing ATPase activity" NARROW [] xref: EC:3.6.3.31 xref: MetaCyc:3.6.3.31-RXN is_a: GO:0015203 ! polyamine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015418 name: quaternary-ammonium-compound-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32] synonym: "ATP phosphohydrolase (quaternary-amine-importing) activity" EXACT [EC:3.6.3.32] synonym: "glycine betaine/proline porter activity" RELATED [] synonym: "quaternary amine uptake transporter activity" EXACT [] synonym: "quaternary-amine-transporting ATPase activity" EXACT [] synonym: "quaternary-ammonium-compound ABC transporter" NARROW [] xref: EC:3.6.3.32 xref: MetaCyc:3.6.3.32-RXN is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015419 name: ATPase-coupled sulfate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in)." [EC:3.6.3.25] synonym: "ATP phosphohydrolase (sulfate-importing) activity" EXACT [EC:3.6.3.25] synonym: "sulfate ABC transporter" NARROW [] synonym: "sulfate transmembrane-transporting ATPase activity" RELATED [] synonym: "sulfate transporting ATPase activity" EXACT [] synonym: "sulfate-transporting ATPase activity" EXACT [EC:3.6.3.25] synonym: "sulfate/thiosulfate porter activity" EXACT [] synonym: "sulphate transporting ATPase activity" EXACT [] synonym: "sulphate-transporting ATPase activity" EXACT [] xref: EC:3.6.3.25 xref: MetaCyc:3.6.3.25-RXN xref: RHEA:10192 is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity [Term] id: GO:0015420 name: cobalamin-transporting ATPase activity namespace: molecular_function alt_id: GO:0015235 def: "Catalysis of the reaction: ATP + H2O + cob(III)alamin(out) = ADP + phosphate + cob(III)alamin(in). Cobalamin is also known as vitamin B12." [EC:3.6.3.33] synonym: "ATP phosphohydrolase (vitamin B12-importing)" EXACT [EC:3.6.3.33] synonym: "cobalamin ABC transporter" NARROW [] synonym: "cobalamin porter activity" BROAD [] synonym: "cobalamin transporter activity" BROAD [] synonym: "vitamin B12 porter activity" BROAD [] synonym: "vitamin B12 transporter activity" BROAD [] synonym: "vitamin B12-transporting ATPase activity" BROAD [] xref: EC:3.6.3.33 xref: MetaCyc:3.6.3.33-RXN xref: reactome:R-HSA-3000122 "CD320 transports extracellular TCII:Cbl to endosome" xref: reactome:R-HSA-3000238 "LMBRD1 transports lysosomal Cbl to cytosol" xref: reactome:R-HSA-3095901 "ABCC1 transports cytosolic Cbl to extracellular region" xref: RHEA:17873 xref: RHEA:32831 is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0015421 name: oligopeptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + oligopeptide(out) = ADP + phosphate + oligopeptide(in)." [EC:3.6.3.23] synonym: "ATP phosphohydrolase (oligopeptide-importing)" EXACT [EC:3.6.3.23] synonym: "oligopeptide ABC transporter" NARROW [] synonym: "oligopeptide permease activity" RELATED [EC:3.6.3.23] xref: EC:3.6.3.23 xref: MetaCyc:3.6.3.23-RXN xref: reactome:R-HSA-5223317 "ABCB9 transports peptides from cytosol to lysosomal lumen" is_a: GO:0015440 ! peptide-transporting ATPase activity is_a: GO:0035673 ! oligopeptide transmembrane transporter activity [Term] id: GO:0015422 name: oligosaccharide-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligosaccharide(out) = ADP + phosphate + oligosaccharide(in)." [EC:3.6.3.18] synonym: "ATP phosphohydrolase (disaccharide-importing)" EXACT [EC:3.6.3.18] synonym: "oligosaccharide ABC transporter" NARROW [] xref: EC:3.6.3.18 xref: MetaCyc:3.6.3.18-RXN xref: RHEA:20364 is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0015423 name: maltose-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltose(out) = ADP + phosphate + maltose(in)." [EC:3.6.3.19] synonym: "ATP phosphohydrolase (maltose-importing)" EXACT [EC:3.6.3.19] synonym: "maltose ABC transporter" NARROW [] xref: EC:3.6.3.19 xref: MetaCyc:3.6.3.19-RXN xref: RHEA:22132 is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015422 ! oligosaccharide-transporting ATPase activity [Term] id: GO:0015424 name: amino acid-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out/in) = ADP + phosphate + amino acid(in/out)." [GOC:ai, GOC:mah] synonym: "amino acid ABC transporter" NARROW [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity is_a: GO:0033284 ! carboxylic acid-transporting ATPase activity [Term] id: GO:0015425 name: nonpolar-amino acid-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22] synonym: "ATP phosphohydrolase (nonpolar-amino-acid-transporting) activity" EXACT [EC:3.6.3.22] synonym: "leucine/isoleucine/valine porter activity" RELATED [] synonym: "nonpolar amino acid-transporting ATPase activity" EXACT [] synonym: "nonpolar-amino acid ABC transporter" NARROW [] synonym: "nonpolar-amino-acid-transporting ATPase activity" EXACT [] xref: EC:3.6.3.22 xref: MetaCyc:3.6.3.22-RXN is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0015426 name: polar-amino acid-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21] synonym: "ATP phosphohydrolase (polar-amino-acid-importing) activity" EXACT [EC:3.6.3.21] synonym: "cystine/diaminopimelate porter activity" RELATED [] synonym: "glutamate/aspartate porter activity" RELATED [] synonym: "histidine permease activity" NARROW [EC:3.6.3.21] synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "polar amino acid uptake transporter activity" EXACT [] synonym: "polar amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino acid ABC transporter" NARROW [] synonym: "polar-amino acid-importing ATPase activity" EXACT [] synonym: "polar-amino-acid-transporting ATPase activity" EXACT [EC:3.6.3.21] xref: EC:3.6.3.21 xref: MetaCyc:3.6.3.21-RXN is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0015427 name: obsolete ABC-type efflux porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type efflux porter activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015428 name: obsolete type I protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type I protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015429 name: obsolete peroxisomal fatty acyl transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains both component and function information. synonym: "peroxisomal fatty acyl transporter" EXACT [] is_obsolete: true [Term] id: GO:0015430 name: glycerol-3-phosphate-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-3-phosphate(out) = ADP + phosphate + glycerol-3-phosphate(in)." [EC:3.6.3.20] synonym: "ATP phosphohydrolase (glycerol-3-phosphate-importing)" EXACT [EC:3.6.3.20] synonym: "glycerol-3-phosphate ABC transporter" NARROW [] xref: EC:3.6.3.20 xref: MetaCyc:3.6.3.20-RXN xref: RHEA:21669 is_a: GO:0015169 ! glycerol-3-phosphate transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015431 name: glutathione S-conjugate-exporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out)." [GOC:jl, PMID:1455517] synonym: "ATP-dependent glutathione S-conjugate export pump" EXACT [] synonym: "conjugate transporter activity" BROAD [] synonym: "GS-X pump" EXACT [] synonym: "MRP1/GS-X pump" EXACT [] is_a: GO:0071997 ! glutathione S-conjugate-transporting ATPase activity [Term] id: GO:0015432 name: bile acid-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(in) + ATP + H2O -> bile acid(out) + ADP + phosphate." [TC:3.A.1.207.2] synonym: "bile acid porter activity" NARROW [] xref: reactome:R-HSA-193362 "ABCB11 transports bile salts from cytosol to extracellular region" xref: reactome:R-HSA-194153 "Transport (efflux) of bile salts by ABCC3 (MRP3)" is_a: GO:0015125 ! bile acid transmembrane transporter activity is_a: GO:0033285 ! monocarboxylic acid-transporting ATPase activity is_a: GO:0034040 ! lipid-transporting ATPase activity [Term] id: GO:0015433 name: peptide antigen-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: peptide antigen(in) + ATP = peptide antigen(out) + ADP + phosphate." [TC:3.A.1.209.1] synonym: "major histocompatibility peptide transporter activity" EXACT [] synonym: "peptide antigen ABC transporter" NARROW [] synonym: "peptide antigen transporter activity" BROAD [] xref: reactome:R-HSA-1236949 "Translocation of antigenic peptides back to phagosomes via TAP" xref: reactome:R-HSA-983144 "Transport of Antigen peptide in to ER" is_a: GO:0015440 ! peptide-transporting ATPase activity [Term] id: GO:0015434 name: cadmium-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd (cytosol) = ADP + phosphate + Cd (vacuole)." [EC:3.6.3.46] synonym: "ATP phosphohydrolase (heavy-metal-exporting)" EXACT [EC:3.6.3.46] synonym: "cadmium ABC transporter" NARROW [] synonym: "yeast cadmium factor" RELATED [EC:3.6.3.46] xref: EC:3.6.3.46 xref: MetaCyc:3.6.3.46-RXN is_a: GO:0015086 ! cadmium ion transmembrane transporter activity [Term] id: GO:0015435 name: obsolete ABC-type efflux permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. synonym: "ABC-type efflux permease activity" EXACT [] is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0015436 name: capsular-polysaccharide-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + capsular polysaccharide(in) = ADP + phosphate + capsular polysaccharide(out)." [EC:3.6.3.38] synonym: "ATP phosphohydrolase (capsular-polysaccharide-exporting)" EXACT [EC:3.6.3.38] synonym: "capsular-polysaccharide ABC transporter" NARROW [] xref: EC:3.6.3.38 xref: MetaCyc:3.6.3.38-RXN is_a: GO:0015161 ! capsular polysaccharide transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015437 name: lipopolysaccharide-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipopolysaccharide(in) = ADP + phosphate + lipopolysaccharide(out)." [EC:3.6.3.39] synonym: "ATP phosphohydrolase (lipopolysaccharide-exporting)" EXACT [EC:3.6.3.39] synonym: "lipopolysaccharide ABC transporter" NARROW [] synonym: "LPS-transporting ATPase activity" EXACT [] xref: EC:3.6.3.39 xref: MetaCyc:3.6.3.39-RXN is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity is_a: GO:0034040 ! lipid-transporting ATPase activity [Term] id: GO:0015438 name: teichoic-acid-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + teichoic acid(in) = ADP + phosphate + teichoic acid(out)." [EC:3.6.3.40] synonym: "ATP phosphohydrolase (teichoic-acid-exporting)" EXACT [EC:3.6.3.40] synonym: "teichoic-acid ABC transporter" NARROW [] xref: EC:3.6.3.40 xref: MetaCyc:3.6.3.40-RXN is_a: GO:0015162 ! teichoic acid transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015439 name: heme-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + heme(in) = ADP + phosphate + heme(out)." [EC:3.6.3.41] synonym: "ATP phosphohydrolase (heme-exporting)" EXACT [EC:3.6.3.41] synonym: "haem-transporting ATPase activity" EXACT [] synonym: "heme ABC transporter" NARROW [] xref: EC:3.6.3.41 xref: MetaCyc:3.6.3.41-RXN is_a: GO:0015232 ! heme transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015440 name: peptide-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + peptide(in) = ADP + phosphate + peptide(out). Peptides exported include alpha-hemolysin, cyclolysin, colicin V and siderophores from Gram-negative bacteria, and bacteriocin, subtilin, competence factor and pediocin from Gram-positive bacteria." [EC:3.6.3.43] synonym: "ATP phosphohydrolase (peptide-exporting)" EXACT [EC:3.6.3.43] synonym: "peptide ABC transporter" NARROW [] xref: EC:3.6.3.43 xref: MetaCyc:3.6.3.43-RXN is_a: GO:0033220 ! amide-transporting ATPase activity is_a: GO:1904680 ! peptide transmembrane transporter activity [Term] id: GO:0015441 name: beta-glucan-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + beta-glucan(in) = ADP + phosphate + beta-glucan(out)." [EC:3.6.3.42] synonym: "ATP phosphohydrolase (beta-glucan-exporting)" EXACT [EC:3.6.3.42] synonym: "beta-glucan ABC transporter" NARROW [] xref: EC:3.6.3.42 xref: MetaCyc:3.6.3.42-RXN is_a: GO:0015160 ! beta-glucan transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015442 name: obsolete hydrogen-/sodium-translocating ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + (Na+ or H+)(in) = ADP + phosphate + (Na+ or H+)(out)." [TC:3.A.2.-.-] comment: This term was made obsolete because it is a redundant grouping term based on a TC-DB classification. synonym: "hydrogen-/sodium-translocating ATPase activity" EXACT [] synonym: "proton-/sodium-translocating ATPase activity" EXACT [] is_obsolete: true consider: GO:0008553 consider: GO:0008554 [Term] id: GO:0015443 name: obsolete sodium-transporting two-sector ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out)." [EC:3.6.3.15] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "sodium-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046932 consider: GO:0046962 [Term] id: GO:0015444 name: magnesium-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Mg2+(out) -> ADP + phosphate + Mg2+(in)." [EC:3.6.3.2] synonym: "ATP phosphohydrolase (Mg2+-importing)" EXACT [EC:3.6.3.2] synonym: "magnesium importing ATPase activity" EXACT [] synonym: "magnesium-translocating P-type ATPase activity" RELATED [EC:3.6.3.2] synonym: "Mg(2+)-importing ATPase activity" EXACT [EC:3.6.3.2] synonym: "Mg2+-importing ATPase activity" EXACT [EC:3.6.3.2] xref: EC:3.6.3.2 xref: MetaCyc:3.6.3.2-RXN xref: RHEA:10260 is_a: GO:0015095 ! magnesium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015445 name: silver-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ag+(in) -> ADP + phosphate + Ag+(out)." [EC:3.6.3.53] synonym: "Ag+-exporting ATPase activity" EXACT [EC:3.6.3.53] synonym: "ATP phosphohydrolase (Ag+-exporting)" EXACT [EC:3.6.3.53] synonym: "silver exporting ATPase activity" EXACT [] xref: EC:3.6.3.53 xref: MetaCyc:3.6.3.53-RXN xref: RHEA:14733 is_a: GO:0015080 ! silver ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0015446 name: ATPase-coupled arsenite transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out)." [EC:3.6.3.16] synonym: "arsenical pump-driving ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenical resistance efflux pump" EXACT [] synonym: "arsenite ABC transporter" NARROW [] synonym: "arsenite transporting ATPase activity" EXACT [] synonym: "arsenite-translocating ATPase activity" EXACT [EC:3.6.3.16] synonym: "arsenite-transmembrane transporting ATPase activity" RELATED [] synonym: "arsenite-transporting ATPase activity" EXACT [EC:3.6.3.16, GOC:vw] synonym: "ATP phosphohydrolase (arsenite-exporting) activity" EXACT [EC:3.6.3.16] xref: EC:3.6.3.16 xref: MetaCyc:3.6.3.16-RXN xref: RHEA:11348 is_a: GO:0008490 ! arsenite secondary active transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity is_a: GO:0043225 ! ATPase-coupled anion transmembrane transporter activity is_a: GO:1901683 ! arsenate ion transmembrane transporter activity [Term] id: GO:0015447 name: obsolete type II protein secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type II protein secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015448 name: obsolete type III protein (virulence-related) secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type III protein (virulence-related) secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015449 name: obsolete type IV protein (DNA-protein) secretor activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport] comment: This term was made obsolete because it does not accurately reflect the function of the proteins involved. synonym: "type IV protein (DNA-protein) secretor activity" EXACT [] is_obsolete: true [Term] id: GO:0015450 name: P-P-bond-hydrolysis-driven protein transmembrane transporter activity namespace: molecular_function def: "Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated." [GOC:mtg_transport, ISBN:0815340729] synonym: "protein translocase activity" EXACT [] xref: reactome:R-HSA-1222523 "SodB gets secreted" is_a: GO:0008320 ! protein transmembrane transporter activity is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity [Term] id: GO:0015451 name: decarboxylation-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by decarboxylation of a cytoplasmic substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.B.-.-.-] synonym: "Decarboxylation-driven transporters" RELATED [] xref: TC:3.B is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015452 name: methyl transfer-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane driven by a methyl transfer reaction. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.C.-.-.-] synonym: "Methyltransfer-driven transporters" EXACT [] xref: TC:3.C is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015453 name: oxidoreduction-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by exothermic flow of electrons from a reduced substrate to an oxidized substrate. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.D.-.-.-] synonym: "Oxidoreduction-driven transporters" EXACT [] xref: TC:3.D is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015454 name: light-driven active transmembrane transporter activity namespace: molecular_function def: "Primary active transport of a solute across a membrane, driven by light. Primary active transport is catalysis of the transport of a solute across a membrane, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction and is driven by a primary energy source." [GOC:mtg_transport, ISBN:0815340729, TC:3.E.-.-.-] synonym: "Light absorption-driven transporters" EXACT [] synonym: "light-driven pumps" EXACT [] xref: TC:3.E is_a: GO:0015399 ! primary active transmembrane transporter activity [Term] id: GO:0015459 name: potassium channel regulator activity namespace: molecular_function def: "Modulates potassium channel activity via direct interaction interaction with a potassium channel (binding or modification)." [GOC:dos, GOC:mah] synonym: "potassium channel gating activity" EXACT [] is_a: GO:0099106 ! ion channel regulator activity [Term] id: GO:0015461 name: obsolete endosomal oligosaccharide transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "endosomal oligosaccharide transporter" EXACT [] is_obsolete: true consider: GO:0005768 consider: GO:0015157 [Term] id: GO:0015462 name: ATPase-coupled protein transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein(out) = ADP + phosphate + protein(in)." [EC:3.6.1.3, GOC:jl] synonym: "pilin/fimbrilin exporter activity" NARROW [] synonym: "protein ABC transporter" NARROW [] synonym: "protein-transmembrane transporting ATPase activity" RELATED [] synonym: "protein-transporting ATPase activity" EXACT [] is_a: GO:0015440 ! peptide-transporting ATPase activity is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0015464 name: acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: For nicotinic acetylcholine receptors that act as ion channels, instead use 'acetylcholine-gated cation channel activity ; GO:0022848'. is_a: GO:0004888 ! transmembrane signaling receptor activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0015465 name: obsolete lysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse cells." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products. synonym: "lysin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015466 name: obsolete autolysin activity namespace: molecular_function def: "OBSOLETE. An agent that can lyse the cell in which it is synthesized." [GOC:ma] comment: This term was made obsolete because it represents a class of gene products. synonym: "autolysin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015467 name: G-protein activated inward rectifier potassium channel activity namespace: molecular_function alt_id: GO:0015273 def: "Enables the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel, where the inward rectification is due to a voltage-dependent block of the channel pore by a G protein. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force." [GOC:cb, GOC:mah] synonym: "G protein activated inward rectifier potassium channel activity" EXACT [] synonym: "G protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein enhanced inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-activated inward rectifier potassium channel activity" EXACT [] synonym: "G-protein-enhanced inward rectifier potassium channel activity" EXACT [] xref: reactome:R-HSA-1013020 "Activation of GIRK/Kir3 Channels" is_a: GO:0005242 ! inward rectifier potassium channel activity [Term] id: GO:0015468 name: obsolete colicin namespace: molecular_function def: "OBSOLETE. Plasmid-encoded bacteriocins which are produced by enteric bacteria. Exert a lethal effect on other bacteria including E. coli strains that lack the Col plasmid. Bind to a cell surface receptor and are transported into the periplasm via an energy-dependent process involving a TonB- or TolA-dependent hetero-oligomeric protein complex. Some colicins kill their target cell by inserting into the cytoplasmic membrane where they form voltage-sensitive (trans-negative) channels that depolarize and deenergize the cell, and thereby kill it." [TC:1.C.1.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "colicin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005198 consider: GO:0009405 consider: GO:0019835 consider: GO:0046930 consider: GO:0046931 consider: GO:0090729 [Term] id: GO:0015469 name: obsolete channel-forming toxin activity namespace: molecular_function def: "OBSOLETE. A toxin that exerts its effects by forming a channel in a membrane that allows the unregulated passage of substances into and out of the cell." [GOC:ai] comment: This term was made obsolete because it represents a class of gene products. synonym: "channel-forming toxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0015267 consider: GO:0035915 consider: GO:0046930 consider: GO:0090729 [Term] id: GO:0015470 name: obsolete bacteriocin activity namespace: molecular_function def: "OBSOLETE. Polypeptide antibiotic secreted by bacteria and able to kill bacteria of susceptible strains after absorption by specific cell surface receptor." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "bacteriocin activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0019835 [Term] id: GO:0015471 name: nucleoside-specific channel forming porin activity namespace: molecular_function def: "Enables the energy independent passage of nucleoside, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015472 name: obsolete fimbrium-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of fimbria, extracellular organelles that are used to attach a bacterial cell to a surface, but is not a component of the fimbrium when performing its normal biological function." [GOC:jl, GOC:rb, PMID:7906046] comment: This term was made obsolete because it refers to a class of proteins and a biological process rather than a molecular function. synonym: "fimbrium-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0009297 consider: GO:0030674 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0015473 name: fimbrial usher porin activity namespace: molecular_function def: "A porin that acts in the assembly of fimbria together with fimbrial chaperone." [TC:1.B.11.-.-] is_a: GO:0015288 ! porin activity [Term] id: GO:0015474 name: autotransporter activity namespace: molecular_function def: "Transports a passenger protein from the periplasm to the external milieu; the passenger protein and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.12.-.-] is_a: GO:0015288 ! porin activity [Term] id: GO:0015475 name: adhesin autotransporter activity namespace: molecular_function def: "Enables the transfer of adhesin from the periplasm to the external milieu; the adhesin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015476 name: hemaglutinin autotransporter activity namespace: molecular_function def: "Enables the transfer of hemaglutinin from the periplasm to the external milieu; the hemaglutinin and the porin are the N- and C-terminal regions of the same protein, respectively." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015474 ! autotransporter activity [Term] id: GO:0015477 name: obsolete receptor porin activity namespace: molecular_function def: "OBSOLETE. A porin of the bacterial outer membrane that forms transmembrane pores and transports relatively large molecules from the external milieu to the periplasm in an energized process. Energizing of transport across the outer membrane requires a heterotrimeric complex of proteins, the TonB-ExbB-ExbD complex, or in some cases, the TolA-TolQ-TolR complex. Energizing requires proton motive force across the cytoplasmic membrane." [GOC:mtg_transport, ISBN:0815340729, TC:1.B.13.-.-] comment: This term was made obsolete because it combines two functions that are not linked. synonym: "receptor porin activity" EXACT [] is_obsolete: true [Term] id: GO:0015478 name: oligosaccharide transporting porin activity namespace: molecular_function def: "Enables the transfer of oligosaccharide, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "raffinose porin" NARROW [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015479 name: obsolete outer membrane exporter porin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "outer membrane exporter porin" EXACT [] is_obsolete: true consider: GO:0009279 consider: GO:0015288 [Term] id: GO:0015480 name: obsolete secretin (sensu Bacteria) namespace: molecular_function def: "OBSOLETE. Secretins are Gram-negative bacterial outer membrane proteins that form multimeric pores through which macromolecules, usually proteins, can pass. Form homomultimeric ring structures, 10-20 subunits per complex, with large central pores (inner diameters of 5-10 nm)." [TC:1.B.22.-.-] comment: This term was made obsolete because it represents a class of gene products. synonym: "secretin (sensu Bacteria)" EXACT [] is_obsolete: true consider: GO:0008565 consider: GO:0045203 [Term] id: GO:0015481 name: maltose transporting porin activity namespace: molecular_function def: "Enables the transfer of maltose from one side of a membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch. This transporter is a porin so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] synonym: "maltoporin" EXACT [] xref: Wikipedia:Maltoporin is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015482 name: obsolete voltage-gated anion channel porin activity namespace: molecular_function def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it wrongly combines voltage-gated anion channel activity and porin activity. synonym: "voltage-dependent anion channel porin activity" EXACT [] synonym: "voltage-gated anion channel porin activity" EXACT [] is_obsolete: true [Term] id: GO:0015483 name: long-chain fatty acid transporting porin activity namespace: molecular_function def: "Enables the transfer of long-chain fatty acids from one side of a membrane to the other. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22. This transporter is a porin and so enables the energy independent passage of substances, sized less than 1000 Da, across a membrane. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [CHEBI:15904, GOC:mtg_transport] is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015245 ! fatty acid transmembrane transporter activity is_a: GO:0015288 ! porin activity [Term] id: GO:0015484 name: obsolete hemolysin activity namespace: molecular_function def: "OBSOLETE. Any substance that causes the lysis of red blood cells." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemolysin activity" EXACT [] is_obsolete: true consider: GO:0019836 [Term] id: GO:0015485 name: cholesterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:jl, ISBN:0198506732] is_a: GO:0032934 ! sterol binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0015486 name: glycoside-pentoside-hexuronide:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: (glycoside, pentoside or hexuronide)(out) + monovalent cation(out) = (glycoside, pentoside or hexuronide)(in) + monovalent cation(in). The cation is Na+, Li+ or H+." [TC:2.A.2.-.-] is_a: GO:0005402 ! carbohydrate:cation symporter activity [Term] id: GO:0015487 name: melibiose:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: melibiose(out) + monovalent cation(out) = melibiose(in) + monovalent cation(in)." [TC:2.A.2.1.1] synonym: "melibiose permease activity" RELATED [] synonym: "melibiose:monovalent cation symporter activity" EXACT [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015156 ! melibiose transmembrane transporter activity [Term] id: GO:0015488 name: glucuronide:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucuronide(out) + monovalent cation(out) = glucuronide(in) + monovalent cation(in)." [TC:2.A.2.3.1] synonym: "glucuronide:monovalent cation symporter activity" EXACT [] synonym: "glucuronoside permease activity" RELATED [] is_a: GO:0015164 ! glucuronoside transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0015489 name: putrescine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of putrescine from one side of a membrane to the other. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0015490 name: cadaverine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cadaverine, 1,5-pentanediamine, from one side of a membrane to the other." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015491 name: cation:cation antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cation A(out) + cation B(in) = cation A(in) + cation B(out)." [GOC:ai] is_a: GO:0015298 ! solute:cation antiporter activity is_a: GO:0099516 ! ion antiporter activity [Term] id: GO:0015492 name: phenylalanine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: phenylalanine(out) + H+(out) = phenylalanine(in) + H+(in)." [TC:2.A.3.1.1] synonym: "phenylalanine:hydrogen symporter activity" EXACT [] is_a: GO:0015494 ! aromatic amino acid:proton symporter activity [Term] id: GO:0015493 name: lysine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lysine(out) + H+(out) = lysine(in) + H+(in)." [TC:2.A.3.1.2] synonym: "lysine:hydrogen symporter activity" EXACT [] is_a: GO:0005280 ! amino acid:proton symporter activity [Term] id: GO:0015494 name: aromatic amino acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: aromatic amino acid(out) + H+(out) = aromatic amino acid(in) + H+(in)." [TC:2.A.3.1.3] synonym: "aromatic amino acid:hydrogen symporter activity" EXACT [] is_a: GO:0005280 ! amino acid:proton symporter activity is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity [Term] id: GO:0015495 name: gamma-aminobutyric acid:proton symporter activity namespace: molecular_function alt_id: GO:0005331 alt_id: GO:0015329 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + H+(out) = gamma-aminobutyric acid(in) + H+(in)." [TC:2.A.18.5.1, TC:2.A.3.1.4, TC:2.A.3.4.2] comment: See also the molecular function term 'neurotransmitter transporter activity ; GO:0005326'. synonym: "4-aminobutanoate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutanoate:proton symporter activity" EXACT [] synonym: "4-aminobutyrate:hydrogen symporter activity" EXACT [] synonym: "4-aminobutyrate:proton symporter activity" EXACT [] synonym: "GABA:hydrogen symporter activity" EXACT [] synonym: "GABA:proton symporter activity" EXACT [] synonym: "gamma-aminobutyric acid permease activity" EXACT [] synonym: "gamma-aminobutyric acid:hydrogen symporter activity" EXACT [] xref: reactome:R-HSA-428625 "Vesicular inhibitory amino acid transport" is_a: GO:0005280 ! amino acid:proton symporter activity is_a: GO:0015185 ! gamma-aminobutyric acid transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015496 name: putrescine:ornithine antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: putrescine(out) + ornithine(in) = putrescine(in) + ornithine(out)." [TC:2.A.3.2.1] synonym: "putrescine-ornithine antiporter activity" EXACT [] synonym: "putrescine/ornithine antiporter activity" EXACT [] synonym: "putrescine:hydrogen symporter activity" EXACT [] is_a: GO:0000064 ! L-ornithine transmembrane transporter activity is_a: GO:0015489 ! putrescine transmembrane transporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0015498 name: pantothenate:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: pantothenate(out) + Na+(out) = pantothenate(in) + Na+(in)." [TC:2.A.21.1.1] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity is_a: GO:0140161 ! monocarboxylate:sodium symporter activity [Term] id: GO:0015499 name: formate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015659 def: "Enables the transfer of formate from one side of a membrane to the other. Formate is also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [GOC:ai] synonym: "formate uptake permease activity" EXACT [] synonym: "formate uptake transmembrane transporter activity" RELATED [] xref: RHEA:29679 is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015500 name: obsolete threonine/serine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (threonine or serine)(out) + Na+(out) = (threonine or serine)(in) + Na+(in)." [TC:2.A.23.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "threonine/serine:sodium symporter activity" EXACT [] is_obsolete: true consider: GO:0005283 consider: GO:0015194 consider: GO:0015195 [Term] id: GO:0015501 name: glutamate:sodium symporter activity namespace: molecular_function alt_id: GO:0008027 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + Na+(out) = glutamate(in) + Na+(in)." [TC:2.A.27.1.1] synonym: "sodium/excitatory glutamate cotransporter activity" BROAD [] synonym: "sodium/excitatory glutamate symporter activity" EXACT [] xref: RHEA:29031 is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0017153 ! sodium:dicarboxylate symporter activity [Term] id: GO:0015503 name: glutathione-regulated potassium exporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(in) + H+(out) = K+(out) + H+(in), where glutathione maintains the closed state." [PMID:11053405, TC:2.A.37.1.1, TC:2.A.37.1.2] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015504 name: cytosine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: cytosine(out) + H+(out) = cytosine(in) + H+(in)." [TC:2.A.39.1.1] synonym: "cytosine permease activity" RELATED [] synonym: "cytosine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015209 ! cytosine transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015505 name: uracil:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: uracil(out) + cation(out) = uracil(in) + cation(in)." [GOC:mtg_transport] synonym: "uracil permease activity" RELATED [] is_a: GO:0015210 ! uracil transmembrane transporter activity is_a: GO:0015391 ! nucleobase:cation symporter activity [Term] id: GO:0015506 name: nucleoside:proton symporter activity namespace: molecular_function alt_id: GO:0015536 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + H+(out) = nucleoside(in) + H+(in)." [TC:2.A.1.10.1, TC:2.A.41.1.1] synonym: "nucleoside permease activity" RELATED [] synonym: "nucleoside:hydrogen ion symporter activity" EXACT [] synonym: "nucleoside:hydrogen symporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015507 name: obsolete hydroxy/aromatic amino acid permease activity namespace: molecular_function def: "OBSOLETE. Permease for hydroxy and aromatic amino acids." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "hydroxy/aromatic amino acid permease activity" EXACT [] is_obsolete: true consider: GO:0015171 consider: GO:0015173 [Term] id: GO:0015513 name: high-affinity secondary active nitrite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of nitrite from one side of the membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite uptake permease activity" EXACT [] is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015514 name: nitrite efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitrite from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "nitrite extrusion permease activity" EXACT [] is_a: GO:0015113 ! nitrite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015515 name: citrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + succinate(in) = citrate(in) + succinate(out)." [TC:2.A.47.3.2] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity [Term] id: GO:0015516 name: tartrate:succinate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: tartrate(out) + succinate(in) = tartrate(in) + succinate(out)." [TC:2.A.47.3.3] is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity is_a: GO:0015554 ! tartrate transmembrane transporter activity [Term] id: GO:0015517 name: galactose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: galactose(out) + H+(out) = galactose(in) + H+(in)." [TC:2.A.1.1.1, TC:2.A.1.1.9] synonym: "galactose:hydrogen symporter activity" EXACT [] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] is_a: GO:0005354 ! galactose transmembrane transporter activity is_a: GO:0009679 ! hexose:proton symporter activity [Term] id: GO:0015518 name: arabinose:proton symporter activity namespace: molecular_function alt_id: GO:0015523 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: arabinose(out) + H+(out) = arabinose(in) + H+(in)." [TC:2.A.1.1.2] synonym: "arabinose efflux permease activity" BROAD [] synonym: "arabinose efflux transmembrane transporter activity" BROAD [] synonym: "arabinose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0042900 ! arabinose transmembrane transporter activity [Term] id: GO:0015519 name: D-xylose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: D-xylose(out) + H+(out) = D-xylose(in) + H+(in)." [TC:2.A.1.1.3] synonym: "D-xylose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015148 ! D-xylose transmembrane transporter activity [Term] id: GO:0015520 name: tetracycline:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + tetracycline(in) = H+(in) + tetracycline(out)." [TC:2.A.1.2.4] synonym: "tetracyclin:hydrogen antiporter activity" EXACT [] synonym: "tetracyclin:proton antiporter activity" EXACT [] synonym: "tetracycline:hydrogen antiporter activity" EXACT [] is_a: GO:0008493 ! tetracycline transmembrane transporter activity is_a: GO:0015307 ! drug:proton antiporter activity is_a: GO:0099516 ! ion antiporter activity [Term] id: GO:0015521 name: obsolete bicyclomycin/sulfathiazole:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (bicyclomycin or sulfathiazole)(in) + H+(out) = (bicyclomycin or sulfathiazole)(out) + H+(in)." [TC:2.A.1.2.7] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" EXACT [] synonym: "bicyclomycin/sulfathiazole:proton antiporter activity" EXACT [] synonym: "bicyclomycin/sulphathiazole:hydrogen antiporter activity" EXACT [] is_obsolete: true consider: GO:0015545 consider: GO:0015546 consider: GO:0045119 [Term] id: GO:0015522 name: hydrophobic uncoupler:proton antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hydrophobic uncoupler(in) + H+(out) = hydrophobic uncoupler(out) + H+(in). Hydrophobic uncouplers include CCCP, benzalkonium and SDS." [TC:2.A.1.2.9] synonym: "hydrophobic uncoupler:hydrogen antiporter activity" EXACT [] is_a: GO:0015307 ! drug:proton antiporter activity is_a: GO:0017077 ! oxidative phosphorylation uncoupler activity [Term] id: GO:0015524 name: obsolete L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: H+(out) + (L-arabinose or beta-D-thiogalactopyranoside)(in) = H+(in) + (L-arabinose or beta-D-thiogalactopyranoside)(out)." [TC:2.A.1.2.15] comment: This term was made obsolete because it represents a gene product rather than a single discrete molecular function. synonym: "L-arabinose/beta-D-thiogalactopyranoside:hydrogen antiporter activity" EXACT [] synonym: "L-arabinose/beta-D-thiogalactopyranoside:proton antiporter activity" EXACT [] is_obsolete: true consider: GO:0015147 consider: GO:0015299 consider: GO:0051119 [Term] id: GO:0015525 name: obsolete carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" EXACT [] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:proton antiporter activity" EXACT [] is_obsolete: true consider: GO:0015307 consider: GO:0015547 consider: GO:0015548 consider: GO:0015549 [Term] id: GO:0015526 name: hexose-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose phosphate(out) + inorganic phosphate(in) = hexose phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.1] is_a: GO:0015119 ! hexose phosphate transmembrane transporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0015527 name: glycerol-phosphate:inorganic phosphate antiporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycerol phosphate(out) + inorganic phosphate(in) = glycerol phosphate(in) + inorganic phosphate(out)." [TC:2.A.1.4.3] is_a: GO:0015168 ! glycerol transmembrane transporter activity is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity [Term] id: GO:0015528 name: lactose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactose(out) + H+(out) = lactose(in) + H+(in)." [TC:2.A.1.1.9, TC:2.A.1.5.1] synonym: "lactose, galactose:hydrogen symporter activity" BROAD [] synonym: "lactose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0015529 name: raffinose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: raffinose(out) + H+(out) = raffinose(in) + H+(in)." [TC:2.A.1.5.2] synonym: "raffinose:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015158 ! raffinose transmembrane transporter activity [Term] id: GO:0015530 name: shikimate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of shikimate from one side of a membrane to the other. Shikimate is an important intermediate in the biosynthesis of aromatic amino acids." [GOC:ai] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015531 name: citrate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: citrate(out) + H+(out) = citrate(in) + H+(in)." [TC:2.A.1.6.1] synonym: "citrate:hydrogen symporter activity" EXACT [] xref: RHEA:32123 is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0071913 ! citrate secondary active transmembrane transporter activity [Term] id: GO:0015532 name: alpha-ketoglutarate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-ketoglutarate(out) + H+(out) = alpha-ketoglutarate(in) + H+(in)." [TC:2.A.1.6.2] synonym: "2-oxoglutarate:hydrogen symporter activity" EXACT [] synonym: "2-oxoglutarate:proton symporter activity" EXACT [] synonym: "alpha-ketoglutarate:hydrogen symporter activity" EXACT [] is_a: GO:0015139 ! alpha-ketoglutarate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015533 name: shikimate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: shikimate(out) + H+(out) = shikimate(in) + H+(in)." [TC:2.A.1.6.6] synonym: "shikimate:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0015530 ! shikimate transmembrane transporter activity [Term] id: GO:0015534 name: obsolete proline/glycine/betaine:hydrogen/sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (proline, glycine or betaine)(out) + (H+ or Na+)(out) = (proline, glycine or betaine)(in) + (H+ or Na+)(in)." [TC:2.A.1.6.4] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "proline/glycine/betaine:hydrogen/sodium symporter activity" EXACT [] synonym: "proline/glycine/betaine:proton/sodium symporter" EXACT [] is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015294 consider: GO:0015295 consider: GO:0015370 [Term] id: GO:0015535 name: fucose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: fucose(out) + H+(out) = fucose(in) + H+(in)." [TC:2.A.1.7.1] synonym: "fucose:hydrogen symporter activity" EXACT [] xref: RHEA:29023 is_a: GO:0009679 ! hexose:proton symporter activity is_a: GO:0015150 ! fucose transmembrane transporter activity [Term] id: GO:0015537 name: xanthosine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: xanthosine(out) + H+(out) = xanthosine(in) + H+(in)." [TC:2.A.1.10.2] synonym: "xanthosine permease activity" RELATED [] synonym: "xanthosine:hydrogen ion symporter activity" EXACT [] is_a: GO:0015506 ! nucleoside:proton symporter activity is_a: GO:0015553 ! xanthosine transmembrane transporter activity [Term] id: GO:0015538 name: sialic acid:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sialate(out) + H+(out) = sialate(in) + H+(in)." [TC:2.A.1.12.1] synonym: "sialic acid permease activity" RELATED [] synonym: "sialic acid:hydrogen symporter activity" EXACT [] xref: reactome:R-HSA-428585 "SLC17A5 cotransports Neu5Ac, H+ from lysosomal lumen to cytosol" is_a: GO:0015136 ! sialic acid transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity [Term] id: GO:0015539 name: hexuronate:cation symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexuronate(out) + cation(out) = hexuronate(in) + cation(in). The hexuronate may be glucuronate or galacturonate." [TC:2.A.1.14.2] synonym: "hexuronate (glucuronate/galacturonate) porter activity" NARROW [] synonym: "hexuronate porter activity" RELATED [] is_a: GO:0005402 ! carbohydrate:cation symporter activity is_a: GO:0015134 ! hexuronate transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015540 name: 3-hydroxyphenyl propionate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 3-hydroxyphenyl propionate(out) + H+(out) = 3-hydroxyphenyl propionate(in) + H+(in)." [TC:2.A.1.15.2] synonym: "3-hydroxyphenyl propionate porter activity" RELATED [] synonym: "3-hydroxyphenyl propionate:hydrogen ion symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015551 ! 3-hydroxyphenyl propanoate transmembrane transporter activity [Term] id: GO:0015541 name: secondary active cyanate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of cyanate from one side of a membrane to the other." [TC:2.A.1.17.1] synonym: "cyanate porter activity" RELATED [] is_a: GO:0015110 ! cyanate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0015543 name: obsolete lactose/glucose efflux transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: glucose or lactose(in) = glucose or lactose(out)." [TC:2.A.1.20.2] comment: This term was made obsolete because it represents two molecular functions. synonym: "lactose/glucose efflux transporter activity" EXACT [] is_obsolete: true consider: GO:0015155 [Term] id: GO:0015544 name: phenyl propionate uniporter activity namespace: molecular_function def: "Enables the transfer of phenyl propionate from one side of a membrane to the other." [GOC:mtg_transport, TC:2.A.1.27.1] synonym: "phenyl propionate permease activity" RELATED [] is_a: GO:0015292 ! uniporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0015552 ! propionate transmembrane transporter activity [Term] id: GO:0015545 name: bicyclomycin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of bicyclomycin from one side of a membrane to the other. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] synonym: "bicyclomycin transporter activity" RELATED [] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015546 name: sulfathiazole transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of sulfathiazole from one side of a membrane to the other. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators] synonym: "bicyclomycin/sulfathiazole:hydrogen antiporter activity" RELATED [] synonym: "sulphathiazole transporter activity" EXACT [] is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015547 name: nalidixic acid transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nalidixic acid from one side of a membrane to the other. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] synonym: "nalidixic acid transporter activity" RELATED [] is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity [Term] id: GO:0015548 name: organomercurial transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organomercurial compounds from one side of a membrane to the other. Organomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" NARROW [] synonym: "organomercurial transporter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015549 name: carbonyl cyanide m-chlorophenylhydrazone transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of carbonyl cyanide m-chlorophenylhydrazone from one side of a membrane to the other. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators] synonym: "carbonyl cyanide m-chlorophenylhydrazone transporter activity" RELATED [] synonym: "carbonyl cyanide m-chlorophenylhydrazone/nalidixic acid/organomercurials:hydrogen antiporter activity" RELATED [] synonym: "CCCP transporter activity" EXACT [] is_a: GO:0015238 ! drug transmembrane transporter activity [Term] id: GO:0015550 name: galacturonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of galacturonate from one side of a membrane to the other. Galacturonate is the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:ai] is_a: GO:0015134 ! hexuronate transmembrane transporter activity [Term] id: GO:0015551 name: 3-hydroxyphenyl propanoate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of 3-hydroxyphenyl propanoate from one side of a membrane to the other." [GOC:ai] synonym: "3-hydroxyphenyl propionate transmembrane transporter activity" EXACT [] is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015552 name: propionate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of propionate from one side of a membrane to the other. Propionate (or propanoate) is the organic acid CH3-CH2-COOH." [GOC:ai] is_a: GO:0015636 ! short-chain fatty acid transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0015553 name: xanthosine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of xanthosine, xanthine riboside, from one side of a membrane to the other." [ISBN:0198506732] is_a: GO:0015211 ! purine nucleoside transmembrane transporter activity [Term] id: GO:0015554 name: tartrate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of tartrate from one side of a membrane to the other. Tartrate is the anion of 2,3-dihydroxybutanedioic acid, one of the aldaric acids. The L(+) enantiomer occurs widely in plants, especially in grape juice, and in fungi and bacteria." [GOC:ai] is_a: GO:1901702 ! salt transmembrane transporter activity [Term] id: GO:0015556 name: C4-dicarboxylate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of C4-dicarboxylate from one side of a membrane to the other." [GOC:krc] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0015558 name: secondary active p-aminobenzoyl-glutamate transmembrane transporter activity namespace: molecular_function alt_id: GO:0015569 def: "Enables the transfer of p-aminobenzoyl-glutamate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Secondary active transporters include symporters and antiporters. p-aminobenzoyl-glutamate is the anion of p-aminobenzoyl-glutamic acid." [GOC:ai] synonym: "p-aminobenzoyl-glutamate transmembrane transporter activity" NARROW [] synonym: "p-aminobenzoyl-glutamate transporter activity" RELATED [] synonym: "p-aminobenzoyl-glutamate uptake permease activity" RELATED [] synonym: "p-aminobenzoyl-glutamate uptake transmembrane transporter activity" RELATED [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0071916 ! dipeptide transmembrane transporter activity is_a: GO:0072349 ! modified amino acid transmembrane transporter activity [Term] id: GO:0015560 name: obsolete L-idonate/D-gluconate:hydrogen symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (L-idonate or D-gluconate)(out) + H+(out) = (L-iodonate or D-gluconate)(in) + H+(in)." [TC:2.A.8.1.2] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "L-idonate/D-gluconate:hydrogen symporter activity" EXACT [] synonym: "L-idonate/D-gluconate:proton symporter" EXACT [] is_obsolete: true consider: GO:0015128 consider: GO:0015295 consider: GO:0015568 [Term] id: GO:0015561 name: rhamnose:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: rhamnose(out) + H+(out) = rhamnose(in) + H+(in)." [TC:2.A.7.6.1] synonym: "rhamnose:hydrogen symporter activity" EXACT [] is_a: GO:0009679 ! hexose:proton symporter activity is_a: GO:0015153 ! rhamnose transmembrane transporter activity [Term] id: GO:0015562 name: efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "efflux permease activity" EXACT [] synonym: "monocarboxylate (lactate, pyruvate, mevalonate) uptake/efflux porter activity" RELATED [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015565 name: threonine efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of threonine from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "threonine efflux permease activity" EXACT [] synonym: "threonine export protein" RELATED [] synonym: "threonine export transporter activity" EXACT [] is_a: GO:0015195 ! L-threonine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015566 name: acriflavine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015555 def: "Enables the directed movement of acriflavin from one side of a membrane to the other. Acriflavin is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [PubChem_Compound:6842] synonym: "acriflavin resistant pump activity" RELATED [GOC:dph, GOC:tb] synonym: "acriflavin transporter activity" RELATED [GOC:dph, GOC:tb] synonym: "acriflavine transporter activity" RELATED [] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042910 ! xenobiotic transmembrane transporter activity [Term] id: GO:0015567 name: alkane transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alkanes from one side of a membrane to the other. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0015568 name: L-idonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-idonate from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:ai] synonym: "L-idonate/D-gluconate:hydrogen symporter activity" NARROW [] is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0015571 name: N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015590 def: "Enables the transfer of N-acetylgalactosamine from one side of a membrane to the other. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine permease activity" EXACT [] is_a: GO:0019196 ! galactosamine transmembrane transporter activity [Term] id: GO:0015572 name: N-acetylglucosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015580 def: "Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "D-GlcNAc transmembrane transporter activity" EXACT [] synonym: "N-Acetyl-D-glucosamine permease" RELATED [] synonym: "N-acetyl-D-glucosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylchitosamine transmembrane transporter activity" EXACT [] synonym: "N-acetylglucosamine permease activity" RELATED [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015573 name: beta-glucoside transmembrane transporter activity namespace: molecular_function alt_id: GO:0015582 def: "Enables the transfer of beta-glucosides from one side of a membrane to the other. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, GOC:mtg_transport, http://www.biochem.purdue.edu/, ISBN:0198506732, ISBN:0815340729] synonym: "beta-glucoside permease activity" EXACT [] is_a: GO:0042947 ! glucoside transmembrane transporter activity [Term] id: GO:0015574 name: trehalose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015584 def: "Enables the transfer of trehalose from one side of a membrane to the other. Trehalose is the disaccharide alpha-D-glucopyranosyl-alpha-D-glucopyranoside that acts of a reserve carbohydrate in certain fungi, algae and lichens." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "trehalose permease activity" EXACT [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0015575 name: mannitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015586 def: "Enables the transfer of mannitol from one side of a membrane to the other. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol permease activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015576 name: sorbitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015587 def: "Enables the transfer of sorbitol from one side of a membrane to the other. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] synonym: "glucitol permease activity" EXACT [] synonym: "glucitol transporter activity" EXACT [] synonym: "sorbitol permease activity" EXACT [] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0015577 name: galactitol transmembrane transporter activity namespace: molecular_function alt_id: GO:0015588 def: "Enables the transfer of a galactitol from one side of a membrane to the other. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol permease activity" EXACT [] xref: RHEA:33143 is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0015166 ! polyol transmembrane transporter activity [Term] id: GO:0015578 name: mannose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015589 def: "Enables the transfer of mannose from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "mannose permease activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015583 name: obsolete beta-glucoside [arbutin-salicin-cellobiose] permease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). The beta-glucoside may be arbutin, salicin or cellobiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it arbitrarily groups three substrates. synonym: "beta-glucoside [arbutin-salicin-cellobiose] permease activity" EXACT [] is_obsolete: true [Term] id: GO:0015591 name: D-ribose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of D-ribose from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] is_a: GO:0015146 ! pentose transmembrane transporter activity [Term] id: GO:0015592 name: methylgalactoside transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of methylgalactoside from one side of a membrane to the other. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:mtg_transport, ISBN:0815340729] synonym: "galactose/glucose (methylgalactoside) porter activity" RELATED [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015593 name: allose transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of allose from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0015594 name: putrescine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + putrescine(out) -> ADP + phosphate + putrescine(in)." [EC:3.6.3.31] synonym: "putrescine porter activity" BROAD [] xref: RHEA:29995 is_a: GO:0015417 ! polyamine-transporting ATPase activity is_a: GO:0015489 ! putrescine transmembrane transporter activity [Term] id: GO:0015595 name: spermidine-importing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + spermidine(out) -> ADP + phosphate + spermidine(in)." [EC:3.6.3.31] synonym: "spermidine porter activity" BROAD [] xref: MetaCyc:ABC-24-RXN xref: RHEA:29999 is_a: GO:0015417 ! polyamine-transporting ATPase activity is_a: GO:0015606 ! spermidine transmembrane transporter activity [Term] id: GO:0015596 name: obsolete glycine betaine/proline porter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + quaternary amine(out) = ADP + phosphate + quaternary amine(in)." [EC:3.6.3.32, TC:3.A.1.12.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glycine betaine/proline porter activity" EXACT [] is_obsolete: true consider: GO:0015187 consider: GO:0015193 consider: GO:0015199 consider: GO:0015418 [Term] id: GO:0015597 name: obsolete histidine/arginine/lysine/ornithine porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "histidine/arginine/lysine/ornithine porter activity" EXACT [] is_obsolete: true consider: GO:0000064 consider: GO:0005290 consider: GO:0015181 consider: GO:0015189 consider: GO:0015426 [Term] id: GO:0015598 name: arginine-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arginine(out) -> ADP + phosphate + arginine(in)." [EC:3.6.3.21] synonym: "arginine porter activity" EXACT [] is_a: GO:0015181 ! arginine transmembrane transporter activity is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity [Term] id: GO:0015599 name: glutamine-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glutamine(out) -> ADP + phosphate + glutamine(in)." [EC:3.6.3.21] synonym: "glutamine porter activity" BROAD [] xref: MetaCyc:ABC-12-RXN is_a: GO:0015186 ! L-glutamine transmembrane transporter activity is_a: GO:0015426 ! polar-amino acid-transporting ATPase activity [Term] id: GO:0015600 name: obsolete glutamate/aspartate porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.4] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "glutamate/aspartate porter activity" EXACT [] is_obsolete: true consider: GO:0005313 consider: GO:0015183 consider: GO:0015426 [Term] id: GO:0015601 name: obsolete cystine/diaminopimelate porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + polar amino acid(out) = ADP + phosphate + polar amino acid(in)." [EC:3.6.3.21, TC:3.A.1.3.10] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "cystine/diaminopimelate porter activity" EXACT [] is_obsolete: true consider: GO:0015184 consider: GO:0015426 consider: GO:0015626 [Term] id: GO:0015602 name: obsolete leucine/isoleucine/valine porter activity namespace: molecular_function def: "OBSOLETE. Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + nonpolar amino acid(out) = ADP + phosphate + nonpolar amino acid(in)." [EC:3.6.3.22, TC:3.A.1.4.1] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "leucine/isoleucine/valine porter activity" EXACT [] is_obsolete: true consider: GO:0005304 consider: GO:0015188 consider: GO:0015190 consider: GO:0015425 [Term] id: GO:0015603 name: iron chelate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an iron chelate from one side of a membrane to the other. An iron chelate is a heterocyclic compound having a metal ion attached by coordinate bonds to at least two nonmetal ions." [http://www.onelook.com] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015604 name: organic phosphonate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of phosphonate from one side of a membrane to the other. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:ai] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015605 name: organophosphate ester transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of organophosphate esters from one side of a membrane to the other. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015606 name: spermidine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, from one side of a membrane to the other." [GOC:ai] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015203 ! polyamine transmembrane transporter activity [Term] id: GO:0015607 name: fatty-acyl-CoA transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a fatty acyl CoA group from one side of a membrane to the other. A fatty acyl CoA group is any acyl group derived from a fatty acid with a coenzyme A group attached to it." [GOC:ai] synonym: "fatty acyl CoA transporter activity" EXACT [GOC:curators] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0042887 ! amide transmembrane transporter activity is_a: GO:0071077 ! adenosine 3',5'-bisphosphate transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015608 name: carbohydrate-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + carbohydrate(out) -> ADP + phosphate + carbohydrate(in)." [GOC:ai, TC:3.A.1.1.-, TC:3.A.1.2.-] synonym: "carbohydrate uptake transporter activity" EXACT [] synonym: "sugar transporter" NARROW [] is_a: GO:0043211 ! carbohydrate-transporting ATPase activity [Term] id: GO:0015609 name: maltooligosaccharide-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + maltooligosaccharide(out) -> ADP + phosphate + maltooligosaccharide(in)." [TC:3.A.1.-.-] synonym: "maltooligosaccharide porter activity" BROAD [] is_a: GO:0015157 ! oligosaccharide transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015610 name: glycerol phosphate-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + glycerol-phosphate(out) -> ADP + phosphate + glycerol-phosphate(in)." [TC:3.A.1.-.-] synonym: "glycerol-phosphate porter activity" BROAD [] is_a: GO:0015430 ! glycerol-3-phosphate-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015611 name: D-ribose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-ribose(out) -> ADP + phosphate + D-ribose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "D-ribose porter activity" BROAD [] xref: MetaCyc:ABC-28-RXN is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015591 ! D-ribose transmembrane transporter activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015612 name: L-arabinose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + L-arabinose(out) -> ADP + phosphate + L-arabinose(in)." [EC:3.6.3.17, TC:3.A.1.-.-] synonym: "L-arabinose porter activity" EXACT [] xref: MetaCyc:ABC-2-RXN is_a: GO:0015147 ! L-arabinose transmembrane transporter activity is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015613 name: obsolete galactose/glucose (methylgalactoside) porter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "galactose/glucose (methylgalactoside) porter activity" EXACT [] is_obsolete: true consider: GO:0005354 consider: GO:0005355 consider: GO:0015291 consider: GO:0015592 [Term] id: GO:0015614 name: D-xylose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-xylose(out) -> ADP + phosphate + D-xylose(in)." [TC:3.A.1.-.-] synonym: "D-xylose porter activity" BROAD [] xref: RHEA:29899 is_a: GO:0015148 ! D-xylose transmembrane transporter activity is_a: GO:0015407 ! monosaccharide-transporting ATPase activity is_a: GO:0015608 ! carbohydrate-importing ATPase activity [Term] id: GO:0015615 name: D-allose-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-allose(out) -> ADP + phosphate + D-allose(in)." [TC:3.A.1.-.-] synonym: "D-allose porter activity" BROAD [] is_a: GO:0015593 ! allose transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015616 name: DNA translocase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule." [GOC:mah, PMID:16428451, PMID:17631491] comment: Note that some gene products that possess DNA translocase activity, such as members of the FtsK/SpoIIIE family, can be fixed in place by interactions with other components of the cell; the relative movement between the protein and DNA bound to it results in movement of the DNA within the cell, often across a membrane. is_a: GO:0008094 ! DNA-dependent ATPase activity is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0015617 name: obsolete pilin/fimbrilin exporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "pilin/fimbrilin exporter activity" EXACT [] is_obsolete: true consider: GO:0015462 [Term] id: GO:0015619 name: thiamine pyrophosphate-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + thiamine pyrophosphate(out) = ADP + phosphate + thiamine pyrophosphate(in)." [TC:3.A.1.19.1] synonym: "thiamin pyrophosphate ABC transporter" NARROW [] synonym: "thiamin pyrophosphate porter activity" BROAD [] synonym: "thiamin pyrophosphate transporting ATPase activity" EXACT [GOC:curators] synonym: "TPP transporting ATPase activity" EXACT [] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:1901474 ! azole transmembrane transporter activity is_a: GO:1901682 ! sulfur compound transmembrane transporter activity [Term] id: GO:0015620 name: ferric-enterobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric-enterobactin from one side of a membrane to the other." [GOC:ai] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015621 name: ferric triacetylfusarinine C transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric triacetylfusarinine C from one side of a membrane to the other." [GOC:ai] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015622 name: ferric-hydroxamate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric-hydroxamate from one side of a membrane to the other." [GOC:ai] is_a: GO:0015343 ! siderophore transmembrane transporter activity [Term] id: GO:0015623 name: iron-chelate-transporting ATPase activity namespace: molecular_function alt_id: GO:0015409 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + iron chelate(out) = ADP + phosphate + iron chelate(in). Fe-enterobactin, Fe-dicitrate, Fe-hydroxamate and other siderophores are imported." [EC:3.6.3.34] synonym: "ATP phosphohydrolase (iron-chelate-importing)" EXACT [EC:3.6.3.34] synonym: "ferric/ferric-dicitrate porter" BROAD [] synonym: "iron-chelate ABC transporter" NARROW [] xref: EC:3.6.3.34 xref: MetaCyc:3.6.3.34-RXN is_a: GO:0015603 ! iron chelate transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0015624 name: ferric-enterobactin-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-enterobactin(out) = ADP + phosphate + ferric-enterobactin(in)." [EC:3.6.3.34, TC:3.A.1.-.-] synonym: "ferric-enterobactin ABC transporter" NARROW [] synonym: "ferric-enterobactin porter activity" BROAD [] xref: MetaCyc:ABC-10-RXN is_a: GO:0015620 ! ferric-enterobactin transmembrane transporter activity is_a: GO:0015623 ! iron-chelate-transporting ATPase activity [Term] id: GO:0015625 name: ferric-hydroxamate-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + ferric-hydroxamate(out) = ADP + phosphate + ferric-hydroxamate(in)." [EC:3.6.3.34, TC:3.A.1.-.-] synonym: "ferric-hydroxamate ABC transporter" NARROW [] synonym: "ferric-hydroxamate porter activity" BROAD [] xref: MetaCyc:ABC-11-RXN is_a: GO:0015622 ! ferric-hydroxamate transmembrane transporter activity is_a: GO:0015623 ! iron-chelate-transporting ATPase activity [Term] id: GO:0015626 name: L-diaminopimelate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-diaminopimelate from one side of a membrane to the other. L-diaminopimelate is the L-enantiomer anion of 2,6-diaminoheptanedioic acid." [GOC:go_curators, GOC:jsg, GOC:mah, GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cystine/diaminopimelate porter activity" NARROW [] synonym: "L-diaminopimelate transporter activity" BROAD [] is_a: GO:0015179 ! L-amino acid transmembrane transporter activity [Term] id: GO:0015627 name: type II protein secretion system complex namespace: cellular_component def: "A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex." [PMID:16448494] comment: Note that the type II protein secretion system complex does not include components of the Sec or Tat pathways. For components of these pathways, consider annotating to 'cell envelope Sec complex ; GO:0031522' or 'TAT protein translocation system complex ; GO:0033281'. synonym: "general secretion pathway-associated complex" RELATED [] synonym: "main terminal branch" EXACT [] synonym: "MTB" EXACT [] synonym: "Sec-dependent secretion system-associated complex" RELATED [] synonym: "T2SS-associated complexes" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0015628 name: protein secretion by the type II secretion system namespace: biological_process def: "The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type II protein secretion system complex ; GO:0015627'. This process refers specifically to secretion across the outer membrane. For components of the Sec and Tat pathways, consider annotating to 'protein transport by the Sec complex ; GO:0043952' and 'protein transport by the Tat complex ; GO:0043953'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. synonym: "protein secretion by the general secretion pathway" RELATED [] synonym: "protein secretion by the general secretory pathway" RELATED [] synonym: "protein secretion by the T2S" EXACT [] synonym: "protein secretion by the T2SS" EXACT [] synonym: "protein secretion by the type II protein secretion system" EXACT [] synonym: "type II protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0098776 ! protein transport across the cell outer membrane [Term] id: GO:0015629 name: actin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of actin and associated proteins. Includes actin cytoskeleton-associated complexes." [GOC:jl, ISBN:0395825172, ISBN:0815316194] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015630 name: microtubule cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of microtubules and associated proteins." [GOC:jl, ISBN:0395825172] subset: goslim_aspergillus is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0015631 name: tubulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of tubulin, including microtubules." [GOC:clt] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0015633 name: zinc-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(out) = ADP + phosphate + Zn2+(in)." [TC:3.A.1.-.-] synonym: "zinc porter activity" RELATED [] synonym: "zinc transporting ATPase activity" RELATED [] xref: RHEA:29795 is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0015634 name: lipopolysaccharide exporter activity namespace: molecular_function def: "Enables the transfer of lipopolysaccharide from the inside of the cell to the outside of the cell across a membrane. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:mtg_transport, ISBN:0815340729] synonym: "LPS exporter activity" EXACT [] is_a: GO:0015221 ! lipopolysaccharide transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015636 name: short-chain fatty acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0015635 def: "Enables the transfer of short-chain fatty acids from one side of a membrane to the other. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:mah] synonym: "short-chain fatty acid transporter activity" RELATED [] synonym: "short-chain fatty acid uptake transporter activity" RELATED [] is_a: GO:0015245 ! fatty acid transmembrane transporter activity [Term] id: GO:0015638 name: microcin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a microcin from one side of a membrane to the other." [GOC:mah] synonym: "microcin uptake permease activity" EXACT [] is_a: GO:0042895 ! antibiotic transmembrane transporter activity is_a: GO:1904680 ! peptide transmembrane transporter activity [Term] id: GO:0015640 name: peptidoglycan peptide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptidoglycan peptides from one side of a membrane to the other. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] synonym: "murein peptide transporter activity" EXACT [] synonym: "muropeptide transporter activity" EXACT [] is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity [Term] id: GO:0015641 name: obsolete lipoprotein toxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "lipoprotein toxin" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0015642 name: obsolete bacteriolytic toxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause lysis of bacterial cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products and not a molecular function. synonym: "bacteriolytic toxin activity" EXACT [] is_obsolete: true consider: GO:0019835 [Term] id: GO:0015643 name: toxic substance binding namespace: molecular_function def: "Interacting selectively and non-covalently with a toxic substance, a poisonous substance that causes damage to biological systems." [GOC:bf, GOC:curators, GOC:jl, GOC:pr] synonym: "antitoxin activity" RELATED [] synonym: "lipoprotein antitoxin" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0015644 name: obsolete lipoprotein antitoxin namespace: molecular_function def: "OBSOLETE. Binds to a lipoprotein toxin, which is usually derived from a microorganism, thereby neutralizing it." [GOC:jl] comment: This term was made obsolete because it does not represent a function distinct from its parent term. synonym: "lipoprotein antitoxin" EXACT [] is_obsolete: true replaced_by: GO:0015643 [Term] id: GO:0015645 name: fatty acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of a fatty acid to an acceptor, coupled to the hydrolysis of ATP." [EC:6.2.1.3, GOC:cjk, GOC:mah] synonym: "acid:CoA ligase (AMP-forming) activity" EXACT [EC:6.2.1.3] synonym: "acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "acyl-coenzyme A ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acid CoA ligase activity" EXACT [EC:6.2.1.3] synonym: "fatty acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "fatty-acid ligase activity" EXACT [] is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0015647 name: peptidoglycan transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, from one side of a membrane to the other." [GOC:ai] synonym: "murein transporter activity" EXACT [] is_a: GO:0022884 ! macromolecule transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015648 name: lipid-linked peptidoglycan transporter activity namespace: molecular_function def: "Enables the directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells." [GOC:mah] synonym: "lipid-linked murein transporter activity" EXACT [] is_a: GO:0015647 ! peptidoglycan transmembrane transporter activity [Term] id: GO:0015649 name: 2-keto-3-deoxygluconate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 2-keto-3-deoxygluconate(out) + H+(out) = 2-keto-3-deoxygluconate(in) + H+(in)." [TC:2.A.10.1.1] synonym: "2-keto-3-deoxygluconate:hydrogen symporter activity" EXACT [] is_a: GO:0005351 ! carbohydrate:proton symporter activity is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity is_a: GO:0042879 ! aldonate transmembrane transporter activity [Term] id: GO:0015650 name: lactate:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: lactate (out) + H+ (out) = lactate (in) + H+ (in)." [TC:2.A.14.1.1] synonym: "lactate permease" BROAD [] synonym: "lactate:hydrogen porter activity" EXACT [] synonym: "lactate:hydrogen symporter activity" EXACT [] synonym: "lactate:proton porter activity" EXACT [] is_a: GO:0015129 ! lactate transmembrane transporter activity is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015355 ! secondary active monocarboxylate transmembrane transporter activity [Term] id: GO:0015651 name: quaternary ammonium group transmembrane transporter activity namespace: molecular_function alt_id: GO:0015202 def: "Enables the transfer of quaternary ammonium groups from one side of a membrane to the other. Quaternary ammonium groups are any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [ISBN:0198506732] synonym: "quaternary amine transmembrane transporter activity" EXACT [] synonym: "quaternary ammonium compound transporter activity" EXACT [] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity [Term] id: GO:0015652 name: quaternary ammonium group:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: quaternary ammonium group(out) + H+(out) = quaternary ammonium group(in) + H+(in)." [GOC:ai] synonym: "quaternary ammonium group:hydrogen symporter activity" EXACT [] is_a: GO:0015295 ! solute:proton symporter activity is_a: GO:0015651 ! quaternary ammonium group transmembrane transporter activity [Term] id: GO:0015653 name: glycine betaine:proton symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glycine betaine(out) + H+(out) = glycine betaine(in) + H+(in)." [TC:2.A.15.1.1] synonym: "glycine betaine:hydrogen symporter activity" EXACT [] is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity is_a: GO:0015652 ! quaternary ammonium group:proton symporter activity [Term] id: GO:0015654 name: tellurite transmembrane transporter activity namespace: molecular_function alt_id: GO:0015118 def: "Enables the transfer of tellurite from one side of a membrane to the other. Tellurite is a salt of tellurous acid or an oxide of tellurium which occurs sparingly in tufts of white or yellowish crystals." [CHEBI:30477, GOC:ai] synonym: "tellurite uptake transmembrane transporter activity" RELATED [] synonym: "tellurite-resistance uptake permease activity" RELATED [] synonym: "tellurite-resistance uptake transmembrane transporter activity" RELATED [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0015655 name: alanine:sodium symporter activity namespace: molecular_function alt_id: GO:0044670 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alanine(out) + Na+(out) = alanine(in) + Na+(in)." [GOC:ai] synonym: "sodium:alanine symporter activity" EXACT [] xref: RHEA:29283 is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0022858 ! alanine transmembrane transporter activity [Term] id: GO:0015657 name: branched-chain amino acid:sodium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: branched-chain amino acid(out) + cation(out) = branched-chain amino acid(in) + cation(in)." [TC:2.A.26.1.1] is_a: GO:0005283 ! amino acid:sodium symporter activity is_a: GO:0015658 ! branched-chain amino acid transmembrane transporter activity [Term] id: GO:0015658 name: branched-chain amino acid transmembrane transporter activity namespace: molecular_function alt_id: GO:1901240 def: "Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [CHEBI:22918, GOC:ai, GOC:bf, GOC:mtg_transport, ISBN:0815340729] synonym: "branched-chain aliphatic amino acid transmembrane transporter activity" EXACT [GOC:bf] synonym: "branched-chain aliphatic amino acid transporter activity" EXACT [] synonym: "leucine/valine/isoleucine permease activity" RELATED [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015171 ! amino acid transmembrane transporter activity [Term] id: GO:0015660 name: formate efflux transmembrane transporter activity namespace: molecular_function alt_id: GO:0015509 def: "Enables the transfer of formate from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "formate efflux permease activity" RELATED [] is_a: GO:0015499 ! formate transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0015661 name: L-lysine efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "L-lysine exporter activity" EXACT [] synonym: "L-lysine, 2,6-diaminohexanoic acid efflux transmembrane transporter activity" EXACT [] is_a: GO:0015189 ! L-lysine transmembrane transporter activity is_a: GO:0034639 ! L-amino acid efflux transmembrane transporter activity [Term] id: GO:0015662 name: ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of ions across a membrane. The reaction is characterized by the transient formation of a high-energy aspartyl-phosphoryl-enzyme intermediate." [PMID:10322420, PMID:10600683] synonym: "P-type ATPase activity" EXACT [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] xref: reactome:R-HSA-429157 "ABCC4 accumulation of dense granule contents" is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity [Term] id: GO:0015663 name: nicotinamide mononucleotide transmembrane transporter activity namespace: molecular_function alt_id: GO:0015664 def: "Enables the directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of d-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544] synonym: "nicotinamide mononucleotide permease activity" RELATED [] synonym: "nicotinamide ribonucleotide transmembrane transporter activity" EXACT [] is_a: GO:0015215 ! nucleotide transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0015665 name: alcohol transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an alcohol from one side of a membrane to the other. An alcohol is any carbon compound that contains a hydroxyl group." [ISBN:0198506732] is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0015666 name: restriction endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mlg] synonym: "restriction endonuclease activity" EXACT [] synonym: "restriction enzyme activity" EXACT [] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0015667 name: site-specific DNA-methyltransferase (cytosine-N4-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA cytosine = S-adenosyl-L-homocysteine + DNA N4-methylcytosine." [EC:2.1.1.113] synonym: "DNA[cytosine-N4]methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "m4C-forming MTase activity" EXACT [EC:2.1.1.113] synonym: "modification methylase activity" RELATED [EC:2.1.1.113] synonym: "N(4)-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "N4-cytosine-specific DNA methylase activity" EXACT [EC:2.1.1.113] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase activity" EXACT [EC:2.1.1.113] synonym: "S-adenosyl-L-methionine:DNA-cytosine N4-methyltransferase activity" EXACT [EC:2.1.1.113] xref: EC:2.1.1.113 xref: MetaCyc:2.1.1.113-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity [Term] id: GO:0015668 name: type III site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give double-stranded fragments with terminal 5'-phosphates. ATP hydrolysis is required. Cleavage is dependent on the presence of two copies of a specific recognition sequence in an inverse orientation in the DNA. Cleavage occurs at a specific distance from one of the recognition sites." [EC:3.1.21.5, PMID:12654995] synonym: "type III restriction enzyme activity" EXACT [] xref: EC:3.1.21.5 xref: MetaCyc:3.1.21.5-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0015669 name: gas transport namespace: biological_process def: "The directed movement of substances that are gaseous in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport [Term] id: GO:0015670 name: carbon dioxide transport namespace: biological_process def: "The directed movement of carbon dioxide (CO2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport is_a: GO:0015893 ! drug transport is_a: GO:0019755 ! one-carbon compound transport [Term] id: GO:0015671 name: oxygen transport namespace: biological_process def: "The directed movement of oxygen (O2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015669 ! gas transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015672 name: monovalent inorganic cation transport namespace: biological_process def: "The directed movement of inorganic cations with a valency of one into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic cations are atoms or small molecules with a positive charge which do not contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006812 ! cation transport [Term] id: GO:0015673 name: silver ion transport namespace: biological_process def: "The directed movement of silver (Ag) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "silver transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015675 name: nickel cation transport namespace: biological_process def: "The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015676 name: vanadium ion transport namespace: biological_process def: "The directed movement of vanadium (V) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0015677 name: copper ion import namespace: biological_process def: "The directed movement of copper ions into a cell or organelle." [GOC:ai] synonym: "copper ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006825 ! copper ion transport [Term] id: GO:0015679 name: plasma membrane copper ion transport namespace: biological_process def: "The directed movement of copper ions across the plasma membrane." [GOC:ai] synonym: "plasma membrane copper transport" EXACT [] is_a: GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0015680 name: protein maturation by copper ion transfer namespace: biological_process def: "A process that contributes to the delivery of copper ions to a target protein." [GOC:ai] synonym: "intracellular copper delivery" EXACT [] synonym: "intracellular copper ion delivery" RELATED [] synonym: "intracellular copper ion transport" BROAD [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0015685 name: ferric-enterobactin import into cell namespace: biological_process def: "A process in which ferric-enterobactin, the iron-bound form of the siderophore enterobactin, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] synonym: "ferric-enterobactin transport" BROAD [] is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0042930 ! enterobactin transport [Term] id: GO:0015686 name: ferric triacetylfusarinine C import into cell namespace: biological_process def: "The directed movement of ferric triacetylfusarinine C into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "ferric triacetylfusarinine C transport" BROAD [] is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015687 name: ferric-hydroxamate import into cell namespace: biological_process def: "A process in which ferric-hydroxamate, the iron-bound form of the iron chelator hydroxamate, is transported into the cell by specific cell surface receptors." [GOC:pg, PMID:23192658] synonym: "ferric-hydroxamate transport" BROAD [] is_a: GO:0015711 ! organic anion transport is_a: GO:0033214 ! siderophore-dependent iron import into cell is_a: GO:0042886 ! amide transport [Term] id: GO:0015689 name: molybdate ion transport namespace: biological_process def: "The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid." [GOC:ai] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015690 name: aluminum cation transport namespace: biological_process def: "The directed movement of aluminum (Al) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "aluminium ion transport" EXACT [] synonym: "aluminium transport" EXACT [] synonym: "aluminum ion transport" RELATED [] synonym: "aluminum transport" EXACT [] is_a: GO:0030001 ! metal ion transport is_a: GO:0072512 ! trivalent inorganic cation transport [Term] id: GO:0015691 name: cadmium ion transport namespace: biological_process def: "The directed movement of cadmium (Cd) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "cadmium transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015692 name: lead ion transport namespace: biological_process def: "The directed movement of lead (Pb) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0015693 name: magnesium ion transport namespace: biological_process def: "The directed movement of magnesium (Mg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "magnesium transport" RELATED [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0015694 name: mercury ion transport namespace: biological_process def: "The directed movement of mercury (Hg) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "mercuric ion transport" NARROW [] synonym: "mercury transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0072511 ! divalent inorganic cation transport relationship: part_of GO:0050787 ! detoxification of mercury ion [Term] id: GO:0015695 name: organic cation transport namespace: biological_process def: "The directed movement of organic cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic cations are atoms or small molecules with a positive charge which contain carbon in covalent linkage." [GOC:ai] is_a: GO:0006812 ! cation transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015696 name: ammonium transport namespace: biological_process def: "The directed movement of ammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732] synonym: "ammonia transport" RELATED [] is_a: GO:0006812 ! cation transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015697 name: quaternary ammonium group transport namespace: biological_process alt_id: GO:0015845 def: "The directed movement into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore of quaternary ammonium compounds, any compound that can be regarded as derived from ammonium hydroxide or an ammonium salt by replacement of all four hydrogen atoms of the NH4+ ion by organic groups." [GOC:ai, ISBN:0198506732] synonym: "quaternary amine transport" EXACT [] synonym: "quaternary ammonium compound transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015698 name: inorganic anion transport namespace: biological_process def: "The directed movement of inorganic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Inorganic anions are atoms or small molecules with a negative charge which do not contain carbon in covalent linkage." [GOC:krc] is_a: GO:0006820 ! anion transport [Term] id: GO:0015699 name: antimonite transport namespace: biological_process def: "The directed movement of antimonite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015700 name: arsenite transport namespace: biological_process def: "The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015701 name: bicarbonate transport namespace: biological_process def: "The directed movement of bicarbonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport [Term] id: GO:0015702 name: chlorate transport namespace: biological_process def: "The directed movement of chlorate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015703 name: chromate transport namespace: biological_process def: "The directed movement of chromate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015704 name: cyanate transport namespace: biological_process def: "The directed movement of cyanate, NCO-, the anion of cyanic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006820 ! anion transport is_a: GO:0019755 ! one-carbon compound transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015705 name: iodide transport namespace: biological_process def: "The directed movement of iodide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015706 name: nitrate transport namespace: biological_process alt_id: GO:0006872 alt_id: GO:0080055 def: "The directed movement of nitrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "low affinity nitrate transport" NARROW [] synonym: "low-affinity nitrate transport" NARROW [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015707 name: nitrite transport namespace: biological_process def: "The directed movement of nitrite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015708 name: silicic acid import across plasma membrane namespace: biological_process alt_id: GO:0051207 alt_id: GO:1902067 def: "The directed movement of silicates from outside of a cell, across the plasma membrane and into the cytosol. Silicates are the salts of silicic acids, and are usually composed of silicon and oxygen (Si[x]O[y]), one or more metals, and possibly hydrogen. Types of silicate include unisilicates, metasilicates and hydrous silicates." [GOC:ai, GOC:krc, http://www.onelook.com] synonym: "silicate transport" BROAD [] synonym: "silicic acid import" RELATED [] synonym: "silicic acid transport" EXACT [] synonym: "silicon uptake" RELATED [] is_a: GO:0098661 ! inorganic anion transmembrane transport is_a: GO:0098739 ! import across plasma membrane [Term] id: GO:0015709 name: thiosulfate transport namespace: biological_process def: "The directed movement of thiosulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "thiosulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015710 name: tellurite transport namespace: biological_process def: "The directed movement of tellurite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0015711 name: organic anion transport namespace: biological_process def: "The directed movement of organic anions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai, GOC:krc] is_a: GO:0006820 ! anion transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015712 name: hexose phosphate transport namespace: biological_process def: "The directed movement of hexose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015713 name: phosphoglycerate transmembrane transport namespace: biological_process def: "The process in which phosphoglycerate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "phosphoglycerate transport" RELATED [] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0042873 ! aldonate transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015714 name: phosphoenolpyruvate transport namespace: biological_process def: "The directed movement of phosphoenolpyruvate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0015715 name: nucleotide-sulfate transport namespace: biological_process def: "The directed movement of nucleotide sulfate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "nucleotide-sulphate transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0015711 ! organic anion transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015716 name: organic phosphonate transport namespace: biological_process def: "The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2)." [GOC:krc] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015717 name: triose phosphate transport namespace: biological_process def: "The directed movement of triose phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "aldotriose phosphate transport" EXACT [] is_a: GO:0015748 ! organophosphate ester transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015718 name: monocarboxylic acid transport namespace: biological_process def: "The directed movement of monocarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0015719 name: allantoate transport namespace: biological_process def: "The directed movement of allantoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "allantoin/allantoate transport" BROAD [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015720 name: allantoin transport namespace: biological_process def: "The directed movement of allantoin, (2,5-dioxo-4-imidazolidinyl)urea, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "allantoin transmembrane transport" EXACT [GOC:mah] synonym: "allantoin/allantoate transport" BROAD [] is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015721 name: bile acid and bile salt transport namespace: biological_process def: "The directed movement of bile acid and bile salts into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:dph, GOC:krc, PMID:12663868, PMID:14699511] synonym: "bile acid transport" NARROW [] synonym: "bile salt transport" NARROW [] is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015722 name: canalicular bile acid transport namespace: biological_process def: "Enables the transfer of bile acid from one side of a hepatocyte plasma membrane into a bile canaliculus. Bile canaliculi are the thin tubes formed by hepatocyte membranes. Bile acids are any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:dph] is_a: GO:0015721 ! bile acid and bile salt transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0015723 name: bilirubin transport namespace: biological_process def: "The directed movement of bilirubin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015724 name: formate transport namespace: biological_process def: "The directed movement of formate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015726 name: L-idonate transmembrane transport namespace: biological_process def: "The process in which L-idonate is transported across a lipid bilayer, from one side of a membrane to the other. L-idonate is an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [GOC:krc] synonym: "L-idonate transport" RELATED [] is_a: GO:0042873 ! aldonate transmembrane transport [Term] id: GO:0015727 name: lactate transport namespace: biological_process def: "The directed movement of lactate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices." [GOC:ai, ISBN:0198506732] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015728 name: mevalonate transport namespace: biological_process def: "The directed movement of mevalonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015729 name: oxaloacetate transport namespace: biological_process def: "The directed movement of oxaloacetate, the anion of oxobutanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015730 name: propanoate transport namespace: biological_process def: "The directed movement of propionate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "propionate transport" EXACT [] is_a: GO:0015912 ! short-chain fatty acid transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015731 name: 3-hydroxyphenyl propanoate transport namespace: biological_process def: "The directed movement of 3-hydroxyphenyl propanoate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "3-hydroxyphenyl propionate transport" EXACT [] is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015732 name: prostaglandin transport namespace: biological_process def: "The directed movement of prostaglandins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015908 ! fatty acid transport is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0015733 name: shikimate transmembrane transport namespace: biological_process def: "The process in which shikimate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "shikimate transport" RELATED [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015734 name: taurine transport namespace: biological_process def: "The directed movement of taurine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport is_a: GO:0015849 ! organic acid transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015735 name: uronic acid transmembrane transport namespace: biological_process def: "The process in which uronic acid is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "uronic acid transport" RELATED [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015736 name: hexuronate transmembrane transport namespace: biological_process def: "The process in which hexuronate is transported across a lipid bilayer, from one side of a membrane to the other. A hexuronate is any monocarboxylic acid derived from a hexose by oxidation of C-6." [GOC:ai, ISBN:0198506732] synonym: "hexuronate transport" RELATED [] is_a: GO:0015735 ! uronic acid transmembrane transport [Term] id: GO:0015737 name: galacturonate transmembrane transport namespace: biological_process def: "The process in which galacturonate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "galacturonate transport" RELATED [] is_a: GO:0015736 ! hexuronate transmembrane transport [Term] id: GO:0015738 name: glucuronate transmembrane transport namespace: biological_process def: "The process in which glucuronate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "glucuronate transport" RELATED [] is_a: GO:0015736 ! hexuronate transmembrane transport [Term] id: GO:0015739 name: sialic acid transport namespace: biological_process def: "The directed movement of sialic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015740 name: C4-dicarboxylate transport namespace: biological_process def: "The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms." [GOC:krc, GOC:mah] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0015741 name: fumarate transport namespace: biological_process def: "The directed movement of fumarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015742 name: alpha-ketoglutarate transport namespace: biological_process def: "The directed movement of alpha-ketoglutarate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "2-oxoglutarate transport" EXACT [] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0015743 name: malate transport namespace: biological_process def: "The directed movement of malate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "mitochondrial alpha-ketoglutarate/malate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport [Term] id: GO:0015744 name: succinate transport namespace: biological_process def: "The directed movement of succinate, the dianion of ethane dicarboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015745 name: tartrate transmembrane transport namespace: biological_process def: "The process in which tartrate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:krc] synonym: "tartrate transport" RELATED [] is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0042869 ! aldarate transmembrane transport [Term] id: GO:0015746 name: citrate transport namespace: biological_process def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015747 name: urate transport namespace: biological_process def: "The directed movement of urate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc] synonym: "urate transmembrane transport" EXACT [GOC:mah] synonym: "uric acid transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015748 name: organophosphate ester transport namespace: biological_process def: "The directed movement of organophosphate esters into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Organophosphate esters are small organic molecules containing phosphate ester bonds." [GOC:mcc] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015749 name: monosaccharide transmembrane transport namespace: biological_process alt_id: GO:1905950 def: "The process in which a monosaccharide is transported across a lipid bilayer, from one side of a membrane to the other. Monosaccharides are the simplest carbohydrates; they are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [GO_REF:0000069, GOC:TermGenie, GOC:vw] synonym: "monosaccharide transport" RELATED [] is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0015750 name: pentose transmembrane transport namespace: biological_process def: "The process in which pentose is transported across a lipid bilayer, from one side of a membrane to the other. A pentose is any aldose with a chain of five carbon atoms in the molecule." [GOC:ai] synonym: "pentose transport" RELATED [] is_a: GO:0015749 ! monosaccharide transmembrane transport [Term] id: GO:0015751 name: arabinose transmembrane transport namespace: biological_process def: "The process in which arabinose, a pentose monosaccharide that occurs in both D and L configurations, is transported across a lipid bilayer, from one side of a membrane to the other." [CHEBI:22599, GOC:jl] synonym: "arabinose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015752 name: D-ribose transmembrane transport namespace: biological_process def: "The process in which D-ribose is transported across a lipid bilayer, from one side of a membrane to the other. As beta-D-ribofuranose, D-ribose forms the glycose group of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [GOC:ai] synonym: "D-ribose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015753 name: D-xylose transmembrane transport namespace: biological_process def: "The process in which D-xylose is transported across a lipid bilayer, from one side of a membrane to the other. D-xylose (the naturally occurring enantiomer is always D-) is a constituent of plant polysaccharides." [GOC:ai] synonym: "D-xylose transport" RELATED [] is_a: GO:0015750 ! pentose transmembrane transport [Term] id: GO:0015754 name: allose transmembrane transport namespace: biological_process def: "The process in which allose is transported across a lipid bilayer, from one side of a membrane to the other. Allose is an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [GOC:ai] synonym: "allose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015755 name: fructose transmembrane transport namespace: biological_process def: "The directed movement of fructose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai] synonym: "fructose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015756 name: fucose transmembrane transport namespace: biological_process def: "The process in which fucose is transported across a lipid bilayer, from one side of a membrane to the other. Fucose is 6-deoxygalactose and has two enantiomers, D-fucose and L-fucose." [GOC:ai] synonym: "fucose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015757 name: galactose transmembrane transport namespace: biological_process def: "The process in which galactose is transported across a lipid bilayer, from one side of a membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai] synonym: "galactose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015759 name: beta-glucoside transport namespace: biological_process def: "The directed movement of beta-glucosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucosides are glycosides in which the sugar group is a glucose residue, and the anomeric carbon of the bond is in a beta configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0015760 name: glucose-6-phosphate transport namespace: biological_process def: "The directed movement of glucose-6-phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucose-6-phosphate is a monophosphorylated derivative of glucose with the phosphate group attached to C-6." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015712 ! hexose phosphate transport [Term] id: GO:0015761 name: mannose transmembrane transport namespace: biological_process def: "The process in which mannose is transported across a lipid bilayer, from one side of a membrane to the other. Mannose is the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [GOC:ai] synonym: "mannose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015762 name: rhamnose transmembrane transport namespace: biological_process def: "The process in which rhamnose is transported across a lipid bilayer, from one side of a membrane to the other. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [GOC:ai] synonym: "rhamnose transport" RELATED [] is_a: GO:0008645 ! hexose transmembrane transport [Term] id: GO:0015763 name: N-acetylgalactosamine transport namespace: biological_process def: "The directed movement of N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. N-acetylgalactosamine, 2-acetamido-2-deoxygalactopyranose, is the n-acetyl derivative of galactosamine." [GOC:ai] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015764 name: N-acetylglucosamine transport namespace: biological_process def: "The directed movement of N-acetylglucosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015765 name: methylgalactoside transport namespace: biological_process def: "The directed movement of methylgalactoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Methylgalactoside is a compound in which the H of the OH group on carbon-1 of galactose is replaced by a methyl group." [CHEBI:55507, GOC:curators] is_a: GO:1901656 ! glycoside transport [Term] id: GO:0015766 name: disaccharide transport namespace: biological_process def: "The directed movement of disaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Disaccharides are sugars composed of two monosaccharide units." [GOC:ai] is_a: GO:0015772 ! oligosaccharide transport [Term] id: GO:0015767 name: lactose transport namespace: biological_process def: "The directed movement of lactose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Lactose is a disaccharide 4-O-beta-D-galactopyranosyl-D-glucose, and constitutes roughly 5% of the milk in almost all mammals." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015768 name: maltose transport namespace: biological_process def: "The directed movement of maltose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the catabolism of glycogen and starch." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015769 name: melibiose transport namespace: biological_process def: "The directed movement of melibiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Melibiose is the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015770 name: sucrose transport namespace: biological_process def: "The directed movement of sucrose into, out of or within a cell, or between cells by means of some agent such as a transporter or pore. Sucrose is the disaccharide fructofuranosyl-glucopyranoside." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015771 name: trehalose transport namespace: biological_process def: "The directed movement of trehalose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Trehalose is a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0015772 name: oligosaccharide transport namespace: biological_process def: "The directed movement of oligosaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligosaccharides are molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015773 name: raffinose transport namespace: biological_process def: "The directed movement of raffinose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Raffinose occurs in plants almost as commonly as sucrose and is present in cereal grains, cotton seeds, and many legumes. It is synthesized from sucrose by transfer of a galactopyranoside from myo-inositol." [ISBN:0198506732] is_a: GO:2001088 ! trisaccharide transport [Term] id: GO:0015774 name: polysaccharide transport namespace: biological_process def: "The directed movement of polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A polysaccharide is a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:ai] is_a: GO:0008643 ! carbohydrate transport relationship: part_of GO:0033037 ! polysaccharide localization [Term] id: GO:0015775 name: beta-glucan transport namespace: biological_process def: "The directed movement of beta-glucans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Beta-glucans are compounds composed of glucose residues linked by beta-glucosidic bonds." [GOC:ai] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015776 name: capsular polysaccharide transport namespace: biological_process def: "The directed movement of capsular polysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Capsular polysaccharides make up the capsule, a protective structure surrounding some species of bacteria and fungi." [GOC:ai] synonym: "capsular-polysaccharide transport" EXACT [] synonym: "capsule polysaccharide transport" EXACT [] is_a: GO:0015774 ! polysaccharide transport [Term] id: GO:0015777 name: teichoic acid transport namespace: biological_process def: "The directed movement of teichoic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Teichoic acid is any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [GOC:ai] is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015778 name: hexuronide transport namespace: biological_process def: "The directed movement of hexuronide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Hexuronides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of a hexuronate." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0015779 name: glucuronoside transport namespace: biological_process def: "The directed movement of glucuronosides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glucuronosides are any compound formed by combination of glycosidic linkage of a hydroxy compound (e.g. an alcohol or a saccharide) with the anomeric carbon atom of glucuronate." [GOC:ai] synonym: "glucuronide transport" EXACT [] is_a: GO:0046942 ! carboxylic acid transport is_a: GO:1901656 ! glycoside transport [Term] id: GO:0015780 name: nucleotide-sugar transmembrane transport namespace: biological_process def: "The directed movement of nucleotide-sugars into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nucleotide-sugars are any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732] synonym: "nucleotide-sugar transport" RELATED [] is_a: GO:0015931 ! nucleobase-containing compound transport is_a: GO:0055085 ! transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015782 name: CMP-N-acetylneuraminate transmembrane transport namespace: biological_process def: "The directed movement of CMP-N-acetylneuraminate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "CMP-N-acetylneuraminate transport" RELATED [] synonym: "CMP-sialic acid transport" BROAD [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015783 name: GDP-fucose transmembrane transport namespace: biological_process def: "The directed movement of GDP-fucose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-fucose transport" RELATED [] is_a: GO:0090480 ! purine nucleotide-sugar transmembrane transport [Term] id: GO:0015786 name: UDP-glucose transmembrane transport namespace: biological_process def: "The process in which UDP-glucose is transported across a membrane." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015787 name: UDP-glucuronic acid transmembrane transport namespace: biological_process def: "The directed movement of UDP-glucuronic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-glucuronic acid transport" RELATED [] is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015789 name: UDP-N-acetylgalactosamine transmembrane transport namespace: biological_process def: "The directed movement of UDP-N-acetylgalactosamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015790 name: UDP-xylose transmembrane transport namespace: biological_process def: "The directed movement of UDP-xylose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-xylose transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0090481 ! pyrimidine nucleotide-sugar transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0015791 name: polyol transport namespace: biological_process def: "The directed movement of polyols, any polyhydric alcohol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015792 name: arabinitol transmembrane transport namespace: biological_process def: "The process in which arabitol is transported across a lipid bilayer, from one side of a membrane to the other. Arabitol is the pentitol derived from arabinose or lyxose by reduction of the aldehyde group. The D enantiomer is present in lichens and mushrooms." [ISBN:0198506732] synonym: "arabinitol transport" RELATED [] synonym: "arabitol transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0015791 ! polyol transport is_a: GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0015793 name: glycerol transport namespace: biological_process def: "The directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Glycerol is 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015794 name: glycerol-3-phosphate transmembrane transport namespace: biological_process def: "The process in which glycerol-3-phosphate is transported across a membrane. Glycerol-3-phosphate is a phosphoric monoester of glycerol." [GOC:ai] synonym: "glycerol-3-phosphate transport" RELATED [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0098656 ! anion transmembrane transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015795 name: sorbitol transport namespace: biological_process def: "The directed movement of sorbitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sorbitol, also known as glucitol, is the hexitol derived by the reduction of the aldehyde group of glucose." [GOC:ai, ISBN:0198506732] synonym: "glucitol transport" EXACT [] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015796 name: galactitol transport namespace: biological_process def: "The directed movement of galactitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Galactitol is the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015797 name: mannitol transport namespace: biological_process def: "The directed movement of mannitol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Mannitol is the alditol derived from D-mannose by reduction of the aldehyde group." [GOC:ai] is_a: GO:0008643 ! carbohydrate transport is_a: GO:0015791 ! polyol transport [Term] id: GO:0015798 name: myo-inositol transport namespace: biological_process def: "The directed movement of myo-inositol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] synonym: "vitamin Bh transport" EXACT [] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015799 name: propanediol transport namespace: biological_process def: "The directed movement of propanediol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Propanediol is a sweet colorless, viscous, hygroscopic liquid used as an antifreeze and in brake fluid; it is also as a humectant in cosmetics and personal care items, although it can be absorbed through the skin with harmful effects." [http://www.rhymezone.com] is_a: GO:0015791 ! polyol transport [Term] id: GO:0015800 name: acidic amino acid transport namespace: biological_process def: "The directed movement of acidic amino acids, amino acids with a pH below 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015801 name: aromatic amino acid transport namespace: biological_process def: "The directed movement of aromatic amino acids, amino acids with aromatic ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015802 name: basic amino acid transport namespace: biological_process def: "The directed movement of basic amino acids, amino acids with a pH above 7, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015803 name: branched-chain amino acid transport namespace: biological_process alt_id: GO:1900755 def: "The directed movement of branched-chain amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings." [CHEBI:22918, GOC:ai, GOC:bf] synonym: "branched-chain aliphatic amino acid transport" EXACT [GOC:curators] synonym: "branched-chain amino-acid anion transport" EXACT [GOC:jl] synonym: "branched-chain amino-acid anions transport" RELATED [GOC:TermGenie] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015804 name: neutral amino acid transport namespace: biological_process def: "The directed movement of neutral amino acids, amino acids with no net charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015805 name: S-adenosyl-L-methionine transport namespace: biological_process def: "The directed movement of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "S-adenosyl methionine transport" EXACT [] synonym: "S-adenosylmethionine transport" EXACT [] synonym: "SAM transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015806 name: S-methylmethionine transport namespace: biological_process def: "The directed movement of S-methylmethionine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0072337 ! modified amino acid transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015807 name: L-amino acid transport namespace: biological_process def: "The directed movement of L-enantiomer amino acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015808 name: L-alanine transport namespace: biological_process def: "The directed movement of L-alanine, the L-enantiomer of 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032328 ! alanine transport [Term] id: GO:0015809 name: arginine transport namespace: biological_process def: "The directed movement of arginine, 2-amino-5-guanidinopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] synonym: "L-arginine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015810 name: aspartate transmembrane transport namespace: biological_process def: "The process in which aspartate is transported across a lipid bilayer, from one side of a membrane to the other." [GOC:go_curators, ISBN:0198506732] synonym: "aspartate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0015740 ! C4-dicarboxylate transport is_a: GO:0015800 ! acidic amino acid transport [Term] id: GO:0015811 name: L-cystine transport namespace: biological_process def: "The directed movement of L-cystine (also known as dicysteine) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015812 name: gamma-aminobutyric acid transport namespace: biological_process def: "The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] comment: See also the biological process term 'neurotransmitter transport ; GO:0006836'. synonym: "4-aminobutanoate transport" EXACT [] synonym: "4-aminobutyrate transport" EXACT [] synonym: "GABA transport" EXACT [] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006865 ! amino acid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015813 name: L-glutamate transmembrane transport namespace: biological_process alt_id: GO:0089711 def: "The directed movement of L-glutamate across a membrane." [PMID:21307582] synonym: "L-glutamate transport" BROAD [] synonym: "mitochondrial aspartate/glutamate transport" RELATED [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0015800 ! acidic amino acid transport is_a: GO:1902475 ! L-alpha-amino acid transmembrane transport [Term] id: GO:0015814 name: p-aminobenzoyl-glutamate transport namespace: biological_process def: "The directed movement of p-aminobenzoyl-glutamate, the anion of p-aminobenzoyl-glutamic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042938 ! dipeptide transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015816 name: glycine transport namespace: biological_process def: "The directed movement of glycine, aminoethanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006812 ! cation transport is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015804 ! neutral amino acid transport is_a: GO:0015807 ! L-amino acid transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015817 name: histidine transport namespace: biological_process def: "The directed movement of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-histidine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport is_a: GO:0015802 ! basic amino acid transport is_a: GO:0045117 ! azole transport [Term] id: GO:0015818 name: isoleucine transport namespace: biological_process def: "The directed movement of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-isoleucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015819 name: lysine transport namespace: biological_process alt_id: GO:0034226 alt_id: GO:0061461 def: "The directed movement of lysine, 2,6-diaminohexanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-lysine import" NARROW [] synonym: "L-lysine transport" NARROW [] synonym: "lysine import" NARROW [] synonym: "lysine uptake" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015802 ! basic amino acid transport [Term] id: GO:0015820 name: leucine transport namespace: biological_process def: "The directed movement of leucine, 2-amino-4-methylpentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-leucine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015821 name: methionine transport namespace: biological_process def: "The directed movement of methionine, 2-amino-4-(methylthio)butanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-methionine transport" NARROW [] is_a: GO:0000101 ! sulfur amino acid transport is_a: GO:0006812 ! cation transport [Term] id: GO:0015822 name: ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-ornithine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015823 name: phenylalanine transport namespace: biological_process def: "The directed movement of phenylalanine, 2-amino-3-phenylpropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-phenylalanine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015824 name: proline transport namespace: biological_process def: "The directed movement of proline, pyrrolidine-2-carboxylic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-proline transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015825 name: L-serine transport namespace: biological_process alt_id: GO:0090479 def: "The directed movement of L-serine, the L-enantiomer of 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-serine import" NARROW [] is_a: GO:0015807 ! L-amino acid transport is_a: GO:0032329 ! serine transport [Term] id: GO:0015826 name: threonine transport namespace: biological_process def: "The directed movement of threonine, (2R*,3S*)-2-amino-3-hydroxybutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-threonine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015827 name: tryptophan transport namespace: biological_process def: "The directed movement of tryptophan, 2-amino-3-(1H-indol-3-yl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-tryptophan transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015828 name: tyrosine transport namespace: biological_process def: "The directed movement of tyrosine, 2-amino-3-(4-hydroxyphenyl)propanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-tyrosine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015801 ! aromatic amino acid transport [Term] id: GO:0015829 name: valine transport namespace: biological_process def: "The directed movement of valine, 2-amino-3-methylbutanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "L-valine transport" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015803 ! branched-chain amino acid transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0015830 name: diaminopimelate transport namespace: biological_process def: "The directed movement of diaminopimelate, the anion of 2,6-diaminoheptanedioic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0015832 name: obsolete holin namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of gene products. synonym: "holin" EXACT [] is_obsolete: true consider: GO:0008565 consider: GO:0019835 [Term] id: GO:0015833 name: peptide transport namespace: biological_process def: "The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0042886 ! amide transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015834 name: peptidoglycan-associated peptide transport namespace: biological_process def: "The directed movement of peptidoglycan peptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Peptidoglycan peptides are the oligopeptides found in peptidoglycan networks which cross-link the polysaccharide chains." [ISBN:0198506732] synonym: "murein peptide transport" EXACT [] synonym: "muropeptide transport" EXACT [] synonym: "peptidoglycan peptide transport" EXACT [GOC:mah] is_a: GO:0015833 ! peptide transport [Term] id: GO:0015835 name: peptidoglycan transport namespace: biological_process def: "The directed movement of peptidoglycans, a class of glycoconjugates found in bacterial cell walls, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir synonym: "murein transport" EXACT [] is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015836 name: lipid-linked peptidoglycan transport namespace: biological_process def: "The directed movement of lipid-linked peptidoglycans into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "lipid-linked murein transport" EXACT [] is_a: GO:0015835 ! peptidoglycan transport [Term] id: GO:0015837 name: amine transport namespace: biological_process def: "The directed movement of amines, including polyamines, organic compounds containing one or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai, ISBN:0198506732] subset: goslim_pir synonym: "amine/polyamine transport" RELATED [] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015838 name: amino-acid betaine transport namespace: biological_process def: "The directed movement of betaine, the N-trimethyl derivative of an amino acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "betaine transport" EXACT [] is_a: GO:0015697 ! quaternary ammonium group transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015839 name: cadaverine transport namespace: biological_process def: "The directed movement of cadaverine, 1,5-pentanediamine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015840 name: urea transport namespace: biological_process def: "The directed movement of urea into, out of or within the cell. Urea is the water-soluble compound H2N-CO-NH2." [GOC:ai, ISBN:0198506732] is_a: GO:0019755 ! one-carbon compound transport is_a: GO:0042886 ! amide transport [Term] id: GO:0015841 name: chromaffin granule amine transport namespace: biological_process def: "The directed movement of amines into, out of or within chromaffin granules." [GOC:mah] is_a: GO:0015837 ! amine transport [Term] id: GO:0015842 name: aminergic neurotransmitter loading into synaptic vesicle namespace: biological_process def: "The active transport of aminergic neurotransmitters into a synaptic vesicle. This import is fuelled by an electrochemical gradient across the vesicle membrane, established by the action proton pumps." [GOC:ai] is_a: GO:0015837 ! amine transport is_a: GO:0098700 ! neurotransmitter loading into synaptic vesicle [Term] id: GO:0015843 name: methylammonium transport namespace: biological_process def: "The directed movement of methylammonium into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015837 ! amine transport is_a: GO:0019755 ! one-carbon compound transport [Term] id: GO:0015844 name: monoamine transport namespace: biological_process alt_id: GO:0015873 def: "The directed movement of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:25375, GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015846 name: polyamine transport namespace: biological_process def: "The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015847 name: putrescine transport namespace: biological_process def: "The directed movement of putrescine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Putrescine is 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:krc, ISBN:0198506732] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015848 name: spermidine transport namespace: biological_process def: "The directed movement of spermidine, N-(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to putrescine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:krc, ISBN:0198506732] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015846 ! polyamine transport [Term] id: GO:0015849 name: organic acid transport namespace: biological_process def: "The directed movement of organic acids, any acidic compound containing carbon in covalent linkage, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] subset: goslim_pir is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015850 name: organic hydroxy compound transport namespace: biological_process def: "The directed movement of an organic hydroxy compound (organic alcohol) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. An organic hydroxy compound is an organic compound having at least one hydroxy group attached to a carbon atom." [CHEBI:33822, GOC:ai] synonym: "organic alcohol transport" EXACT [CHEBI:33822] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015851 name: nucleobase transport namespace: biological_process def: "The directed movement of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] synonym: "nucleobase transmembrane transport" EXACT [GOC:mah] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015853 name: adenine transport namespace: biological_process def: "The directed movement of adenine, 6-aminopurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators, ISBN:0198506732] synonym: "adenine transmembrane transport" EXACT [GOC:mah] is_a: GO:0006863 ! purine nucleobase transport [Term] id: GO:0015854 name: guanine transport namespace: biological_process def: "The directed movement of guanine, 2-amino-6-hydroxypurine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0006863 ! purine nucleobase transport [Term] id: GO:0015855 name: pyrimidine nucleobase transport namespace: biological_process def: "The directed movement of pyrimidine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [CHEBI:26432, GOC:ai] synonym: "pyrimidine base transmembrane transport" EXACT [GOC:mah] synonym: "pyrimidine base transport" EXACT [GOC:go_curators] synonym: "pyrimidine transmembrane transport" RELATED [GOC:mah] synonym: "pyrimidine transport" RELATED [GOC:curators] is_a: GO:0015851 ! nucleobase transport [Term] id: GO:0015856 name: cytosine transport namespace: biological_process def: "The directed movement of cytosine, 4-amino-2-hydroxypyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] synonym: "cytosine transmembrane transport" EXACT [GOC:mah] is_a: GO:0015855 ! pyrimidine nucleobase transport [Term] id: GO:0015857 name: uracil transport namespace: biological_process def: "The directed movement of uracil, 2,4-dioxopyrimidine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015855 ! pyrimidine nucleobase transport is_a: GO:0015893 ! drug transport [Term] id: GO:0015858 name: nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015931 ! nucleobase-containing compound transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015859 name: intracellular nucleoside transport namespace: biological_process def: "The directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide), within a cell." [GOC:ai] is_a: GO:0015858 ! nucleoside transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0015860 name: purine nucleoside transmembrane transport namespace: biological_process alt_id: GO:0035427 def: "The process in which a purine nucleoside is transported across a membrane. A purine nucleoside is a purine base covalently bonded to a ribose or deoxyribose sugar." [GOC:ai, GOC:vw] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "purine nucleoside membrane transport" EXACT [] synonym: "purine nucleoside transport" BROAD [GOC:vw] is_a: GO:0072530 ! purine-containing compound transmembrane transport is_a: GO:1901642 ! nucleoside transmembrane transport [Term] id: GO:0015861 name: cytidine transport namespace: biological_process def: "The directed movement of cytidine, cytosine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015862 name: uridine transport namespace: biological_process def: "The directed movement of uridine, uracil riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:go_curators] is_a: GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0015863 name: xanthosine transport namespace: biological_process def: "The directed movement of xanthosine, xanthine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [ISBN:0198506732] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0015864 name: pyrimidine nucleoside transport namespace: biological_process def: "The directed movement of a pyrimidine nucleoside, a pyrimidine base covalently bonded to a ribose or deoxyribose sugar, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015858 ! nucleoside transport [Term] id: GO:0015865 name: purine nucleotide transport namespace: biological_process def: "The directed movement of a purine nucleotide, any compound consisting of a purine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0015866 name: ADP transport namespace: biological_process def: "The directed movement of ADP, adenosine diphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015867 name: ATP transport namespace: biological_process def: "The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0015893 ! drug transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015868 name: purine ribonucleotide transport namespace: biological_process def: "The directed movement of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0015865 ! purine nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015869 name: protein-DNA complex transport namespace: biological_process def: "The directed movement of protein-DNA complexes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "DNA-protein complex transport" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0031503 ! protein-containing complex localization is_a: GO:0051027 ! DNA transport [Term] id: GO:0015870 name: acetylcholine transport namespace: biological_process def: "The directed movement of acetylcholine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0009914 ! hormone transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015893 ! drug transport is_a: GO:1901374 ! acetate ester transport [Term] id: GO:0015871 name: choline transport namespace: biological_process def: "The directed movement of choline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Choline (2-hydroxyethyltrimethylammonium) is an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:ai] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport [Term] id: GO:0015872 name: dopamine transport namespace: biological_process def: "The directed movement of dopamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0015696 ! ammonium transport is_a: GO:0015893 ! drug transport is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015874 name: norepinephrine transport namespace: biological_process def: "The directed movement of norepinephrine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [GOC:ai, ISBN:0198506732] synonym: "levarterenol transport" EXACT [] synonym: "noradrenaline transport" EXACT [] is_a: GO:0051937 ! catecholamine transport [Term] id: GO:0015875 name: obsolete vitamin or cofactor transport namespace: biological_process def: "OBSOLETE. The directed movement of vitamins or cofactors into, out of or within a cell, or between cells." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "vitamin or cofactor transport" EXACT [] is_obsolete: true consider: GO:0051180 consider: GO:0051181 [Term] id: GO:0015876 name: acetyl-CoA transport namespace: biological_process def: "The directed movement of acetyl-CoA into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] is_a: GO:0015916 ! fatty-acyl-CoA transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015877 name: biopterin transport namespace: biological_process def: "The directed movement of biopterin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biopterin is a growth factor for certain protozoans and some insects; it is widely distributed in tissues and functions in a reduced form, tetrahydrobiopterin, as a hydroxylation coenzyme." [GOC:ai] is_a: GO:0051182 ! coenzyme transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015878 name: biotin transport namespace: biological_process def: "The directed movement of biotin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Biotin is cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:ai] synonym: "vitamin B7 transport" EXACT [] synonym: "vitamin H transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015879 name: carnitine transport namespace: biological_process def: "The directed movement of carnitine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carnitine is a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:ai] synonym: "vitamin Bt transport" EXACT [] is_a: GO:0015838 ! amino-acid betaine transport [Term] id: GO:0015880 name: coenzyme A transport namespace: biological_process def: "The directed movement of coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, is an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [GOC:ai] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0051503 ! adenine nucleotide transport [Term] id: GO:0015881 name: creatine transmembrane transport namespace: biological_process alt_id: GO:1902598 def: "The directed movement of creatine across a membrane." [GO_REF:0000069, GOC:pr, GOC:TermGenie] synonym: "creatine transport" BROAD [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0006855 ! drug transmembrane transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015882 name: L-ascorbic acid transmembrane transport namespace: biological_process def: "The process in which L-ascorbic acid is transported across a lipid bilayer, from one side of a membrane to the other. L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:ai] synonym: "L-ascorbate transport" EXACT [] synonym: "L-ascorbic acid transport" RELATED [] synonym: "vitamin C transport" EXACT [] is_a: GO:0015749 ! monosaccharide transmembrane transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0051182 ! coenzyme transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015883 name: FAD transport namespace: biological_process def: "The directed movement of flavin-adenine dinucleotide (FAD) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. FAD forms the coenzyme of the prosthetic group of various flavoprotein oxidoreductase enzymes, in which it functions as an electron acceptor by being reversibly converted to its reduced form." [ISBN:0198506732] synonym: "flavin adenine dinucleotide transport" EXACT [] synonym: "flavin-adenine dinucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0015711 ! organic anion transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0015884 name: folic acid transport namespace: biological_process def: "The directed movement of folic acid (pteroylglutamic acid) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transport" EXACT [] synonym: "vitamin B9 transport" EXACT [] synonym: "vitamin M transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0015893 ! drug transport is_a: GO:0042886 ! amide transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015885 name: 5-formyltetrahydrofolate transport namespace: biological_process def: "The directed movement of 5-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate, into, out of, within, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] is_a: GO:0006835 ! dicarboxylic acid transport is_a: GO:0042886 ! amide transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0015886 name: heme transport namespace: biological_process def: "The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "haem transport" EXACT [] is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport is_a: GO:1901678 ! iron coordination entity transport [Term] id: GO:0015887 name: pantothenate transmembrane transport namespace: biological_process def: "The process in which pantothenate is transported across a membrane. Pantothenate is the anion of pantothenic acid, the amide of beta-alanine and pantoic acid; it is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] comment: Note that this term is not intended for use in annotating lateral movement within membranes. synonym: "pantothenate membrane transport" EXACT [] synonym: "pantothenate transport" EXACT [GOC:mah] synonym: "vitamin B5 transport" EXACT [] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0035461 ! vitamin transmembrane transport is_a: GO:0042886 ! amide transport is_a: GO:0051182 ! coenzyme transport is_a: GO:0072337 ! modified amino acid transport is_a: GO:1905039 ! carboxylic acid transmembrane transport [Term] id: GO:0015888 name: thiamine transport namespace: biological_process def: "The directed movement of thiamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Thiamine is vitamin B1, a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:ai] synonym: "thiamin transport" EXACT [GOC:curators] synonym: "vitamin B1 transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0045117 ! azole transport is_a: GO:0051180 ! vitamin transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015889 name: cobalamin transport namespace: biological_process def: "The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "vitamin B12 transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0051181 ! cofactor transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015890 name: nicotinamide mononucleotide transport namespace: biological_process def: "The directed movement of nicotinamide mononucleotide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nicotinamide mononucleotide is a ribonucleotide in which the nitrogenous base, nicotinamide, is in beta-n-glycosidic linkage with the c-1 position of D-ribose. It is a constituent of NAD and NADP." [CHEBI:50383, GOC:curators, ISBN:0721662544] synonym: "nicotinamide ribonucleotide transport" EXACT [] is_a: GO:0006862 ! nucleotide transport is_a: GO:0051181 ! cofactor transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015891 name: siderophore transport namespace: biological_process alt_id: GO:0015892 def: "The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir synonym: "iron-siderochrome transport" NARROW [] synonym: "iron-siderophore transport" EXACT [] synonym: "siderochrome transport" NARROW [] synonym: "siderophore-iron transport" EXACT [] is_a: GO:0051181 ! cofactor transport is_a: GO:1901678 ! iron coordination entity transport [Term] id: GO:0015893 name: drug transport namespace: biological_process def: "The directed movement of a drug, a substance used in the diagnosis, treatment or prevention of a disease, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir is_a: GO:0006810 ! transport relationship: part_of GO:0042493 ! response to drug [Term] id: GO:0015894 name: acriflavine transport namespace: biological_process def: "The directed movement of acriflavine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Acriflavine is a fluorescent dye used as a local antiseptic and also as a biological stain. It intercalates into nucleic acids thereby inhibiting bacterial and viral replication." [GOC:curators, PubChem_Compound:6842] synonym: "acriflavin transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0006821 ! chloride transport is_a: GO:0015695 ! organic cation transport is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport [Term] id: GO:0015895 name: alkane transport namespace: biological_process def: "The directed movement of alkanes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanes are saturated aliphatic hydrocarbon compounds." [GOC:ai] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015896 name: nalidixic acid transport namespace: biological_process def: "The directed movement of nalidixic acid into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Nalidixic acid is a synthetic antibiotic that interferes with DNA gyrase and inhibits prokaryotic replication." [GOC:curators, PMID:12702699, PubChem_Compound:4221] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015897 name: organomercurial transport namespace: biological_process def: "The process in which an organomercurial compound is transported across a membrane.\nOrganomercurial substances are any organic compound containing a mercury atom." [GOC:ai, PMID:18793329] is_a: GO:0055085 ! transmembrane transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015898 name: amiloride transport namespace: biological_process def: "The directed movement amiloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Amiloride is a potent and specific inhibitor of sodium ion entry into cells. It is used as a potassium-sparing diuretic." [GOC:ai] is_a: GO:0015695 ! organic cation transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015899 name: aminotriazole transport namespace: biological_process def: "The directed movement of aminotriazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminotriazole is an effective weed killer that also possesses some antithyroid activity." [CHEBI:40036, GOC:curators] is_a: GO:0045117 ! azole transport [Term] id: GO:0015900 name: benomyl transport namespace: biological_process def: "The directed movement of benomyl into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Benomyl, methyl 1-(butylcarbamoyl)-2-benzimidazolecarbamate, is a systemic agricultural fungicide used for control of certain fungal diseases of stone fruit." [CHEBI:3015, GOC:curators] is_a: GO:0042886 ! amide transport is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0071702 ! organic substance transport [Term] id: GO:0015901 name: cycloheximide transport namespace: biological_process def: "The directed movement of cycloheximide into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cycloheximide is an antibiotic produced by Streptomyces which interferes with protein synthesis in eukaryotes." [ISBN:0198506732] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0042886 ! amide transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015902 name: carbonyl cyanide m-chlorophenylhydrazone transport namespace: biological_process def: "The directed movement of carbonyl cyanide m-chlorophenylhydrazone into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbonyl cyanide m-chlorophenylhydrazone is a proton ionophore, commonly used as an uncoupling agent and inhibitor of photosynthesis because of its effects on mitochondrial and chloroplast membranes." [CHEBI:3259, GOC:curators] synonym: "CCCP transport" EXACT [] is_a: GO:0015893 ! drug transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015903 name: fluconazole transport namespace: biological_process def: "The directed movement of fluconazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fluconazole is an antifungal drug used for oral candidiasis and cryptococcal meningitis; it is still under study for treatment of vaginal candidiasis and other fungal infections." [CHEBI:46081, GOC:curators] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0045117 ! azole transport [Term] id: GO:0015904 name: tetracycline transport namespace: biological_process def: "The directed movement of tetracycline into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [CHEBI:27902, GOC:curators] synonym: "tetracyclin transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0042891 ! antibiotic transport [Term] id: GO:0015905 name: bicyclomycin transport namespace: biological_process def: "The directed movement of bicyclomycin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Bicyclomycin (or bicozamycin) is an antibacterial drug often used as a livestock feed additive." [ISBN:91191028X] is_a: GO:0042891 ! antibiotic transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015906 name: sulfathiazole transport namespace: biological_process def: "The directed movement of sulfathiazole into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sulfathiazole is an antibacterial agent of the sulfonamide group." [CHEBI:9337, GOC:curators] synonym: "sulphathiazole transport" EXACT [] is_a: GO:0042886 ! amide transport is_a: GO:0042891 ! antibiotic transport is_a: GO:0042908 ! xenobiotic transport is_a: GO:0045117 ! azole transport is_a: GO:0072348 ! sulfur compound transport [Term] id: GO:0015908 name: fatty acid transport namespace: biological_process def: "The directed movement of fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acids are aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0015909 name: long-chain fatty acid transport namespace: biological_process def: "The directed movement of long-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015910 name: long-chain fatty acid import into peroxisome namespace: biological_process def: "The directed movement of long-chain fatty acids into a peroxisome. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai] synonym: "peroxisomal long-chain fatty acid import" EXACT [] synonym: "peroxisomal long-chain fatty acid uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0015919 ! peroxisomal membrane transport is_a: GO:0032365 ! intracellular lipid transport is_a: GO:1902001 ! fatty acid transmembrane transport [Term] id: GO:0015911 name: long-chain fatty acid import across plasma membrane namespace: biological_process def: "The directed movement of long-chain fatty acids from outside of a cell, across the plasma membrane and into the cytosol. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, GOC:ai] synonym: "plasma membrane long-chain fatty acid transport" EXACT [] is_a: GO:0044539 ! long-chain fatty acid import into cell is_a: GO:0098739 ! import across plasma membrane is_a: GO:1902001 ! fatty acid transmembrane transport [Term] id: GO:0015912 name: short-chain fatty acid transport namespace: biological_process def: "The directed movement of short-chain fatty acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0015913 name: short-chain fatty acid import namespace: biological_process def: "The directed movement of short-chain fatty acids into a cell or organelle. Short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, GOC:ai] synonym: "short-chain fatty acid uptake" EXACT [] is_a: GO:0015912 ! short-chain fatty acid transport [Term] id: GO:0015914 name: phospholipid transport namespace: biological_process def: "The directed movement of phospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Phospholipids are any lipids containing phosphoric acid as a mono- or diester." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0015915 name: fatty-acyl group transport namespace: biological_process def: "The directed movement of fatty acyl groups into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A fatty acyl group is any acyl group derived from a fatty acid." [GOC:ai] synonym: "fatty acyl transport" EXACT [GOC:curators] is_a: GO:0006810 ! transport [Term] id: GO:0015916 name: fatty-acyl-CoA transport namespace: biological_process def: "The directed movement of fatty acyl coenzyme A into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Fatty acyl coenzyme A is an acyl group linked to 3'-phosphoadenosine-(5')diphospho(4')pantatheine (coenzyme A)." [GOC:ai, ISBN:0198506732] synonym: "fatty acyl CoA transport" EXACT [GOC:curators] synonym: "fatty acyl coenzyme A transport" EXACT [] synonym: "fatty acyl-CoA transport" EXACT [] is_a: GO:0015711 ! organic anion transport is_a: GO:0015868 ! purine ribonucleotide transport is_a: GO:0042886 ! amide transport is_a: GO:0051503 ! adenine nucleotide transport is_a: GO:1901337 ! thioester transport [Term] id: GO:0015917 name: aminophospholipid transport namespace: biological_process def: "The directed movement of aminophospholipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aminophospholipids contain phosphoric acid as a mono- or diester and an amino (NH2) group." [GOC:ai] is_a: GO:0015914 ! phospholipid transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015918 name: sterol transport namespace: biological_process def: "The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:ai] is_a: GO:0006869 ! lipid transport is_a: GO:0015850 ! organic hydroxy compound transport [Term] id: GO:0015919 name: peroxisomal membrane transport namespace: biological_process def: "The directed movement of substances to, from or across the peroxisomal membrane." [GOC:ai] is_a: GO:0043574 ! peroxisomal transport [Term] id: GO:0015920 name: lipopolysaccharide transport namespace: biological_process def: "The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [GOC:ai] subset: goslim_pir synonym: "LPS transport" EXACT [] is_a: GO:0006869 ! lipid transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0015921 name: lipopolysaccharide export namespace: biological_process def: "The directed movement of lipopolysaccharides out of a cell or organelle." [GOC:ai] synonym: "LPS export" EXACT [] is_a: GO:0015920 ! lipopolysaccharide transport [Term] id: GO:0015922 name: aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: aspartate + O2 = iminosuccinate + hydrogen peroxide." [EC:1.4.3.1, EC:1.4.3.16] is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0015923 name: mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of mannosyl compounds, substances containing a group derived from a cyclic form of mannose or a mannose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015924 name: mannosyl-oligosaccharide mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-D-mannose residues in oligo-mannose oligosaccharides." [EC:3.2.1.-, GOC:ai] xref: EC:3.2.1 is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0015925 name: galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of galactosyl compounds, substances containing a group derived from a cyclic form of galactose or a galactose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015926 name: glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of glucosyl compounds, substances containing a group derived from a cyclic form of glucose or a glucose derivative." [ISBN:0198506732] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015927 name: trehalase activity namespace: molecular_function def: "Catalysis of the hydrolysis of trehalose or a trehalose derivative." [GOC:ai] xref: MetaCyc:TREHALA-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015928 name: fucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of fucosyl compounds, substances containing a group derived from a cyclic form of fucose or a fucose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015929 name: hexosaminidase activity namespace: molecular_function def: "Catalysis of the cleavage of hexosamine or N-acetylhexosamine residues (e.g. N-acetylglucosamine) residues from gangliosides or other glycoside oligosaccharides." [http://www.onelook.com/, ISBN:0721662544] xref: MetaCyc:3.2.1.52-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0015930 name: glutamate synthase activity namespace: molecular_function def: "Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors." [EC:1.4.-.-] is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0015931 name: nucleobase-containing compound transport namespace: biological_process def: "The directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: goslim_yeast synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0015932 name: nucleobase-containing compound transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nucleobases, nucleosides, nucleotides and nucleic acids from one side of a membrane to the other." [GOC:ai] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0015933 name: obsolete flavin-containing electron transporter namespace: molecular_function def: "OBSOLETE. An oxidoreductase which contains either flavin-adenine dinucleotide or flavin mononucleotide as a prosthetic group, utilizes either NADH or NADPH and transfers electrons to other electron transfer proteins." [GOC:kd] comment: This term was made obsolete because it does not describe a molecular function. synonym: "flavin-containing electron transporter" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0015934 name: large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site)." [ISBN:0198506732] synonym: "ribosomal large subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit [Term] id: GO:0015935 name: small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a ribosome." [GOC:mah] subset: goslim_pir synonym: "ribosomal small subunit" EXACT [] is_a: GO:0044391 ! ribosomal subunit [Term] id: GO:0015936 name: coenzyme A metabolic process namespace: biological_process alt_id: GO:0006763 def: "The chemical reactions and pathways involving coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA metabolism" EXACT [] synonym: "coenzyme A metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0033875 ! ribonucleoside bisphosphate metabolic process is_a: GO:0034032 ! purine nucleoside bisphosphate metabolic process [Term] id: GO:0015937 name: coenzyme A biosynthetic process namespace: biological_process alt_id: GO:0006764 def: "The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA biosynthesis" EXACT [] synonym: "coenzyme A anabolism" EXACT [] synonym: "coenzyme A biosynthesis" EXACT [] synonym: "coenzyme A formation" EXACT [] synonym: "coenzyme A synthesis" EXACT [] xref: MetaCyc:COA-PWY xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034030 ! ribonucleoside bisphosphate biosynthetic process is_a: GO:0034033 ! purine nucleoside bisphosphate biosynthetic process [Term] id: GO:0015938 name: coenzyme A catabolic process namespace: biological_process alt_id: GO:0006765 def: "The chemical reactions and pathways resulting in the breakdown of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester." [ISBN:0198547684] synonym: "CoA catabolism" EXACT [] synonym: "coenzyme A breakdown" EXACT [] synonym: "coenzyme A catabolism" EXACT [] synonym: "coenzyme A degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015936 ! coenzyme A metabolic process is_a: GO:0034031 ! ribonucleoside bisphosphate catabolic process is_a: GO:0034034 ! purine nucleoside bisphosphate catabolic process [Term] id: GO:0015939 name: pantothenate metabolic process namespace: biological_process alt_id: GO:0006770 def: "The chemical reactions and pathways involving pantothenate, the anion of pantothenic acid, the amide of beta-alanine and pantoic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate metabolism" EXACT [] synonym: "vitamin B5 metabolic process" EXACT [] synonym: "vitamin B5 metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0015940 name: pantothenate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate anabolism" EXACT [] synonym: "pantothenate biosynthesis" EXACT [] synonym: "pantothenate formation" EXACT [] synonym: "pantothenate synthesis" EXACT [] synonym: "vitamin B5 biosynthesis" EXACT [] synonym: "vitamin B5 biosynthetic process" EXACT [] xref: MetaCyc:PANTOSYN-PWY xref: MetaCyc:PWY-4221 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0015941 name: pantothenate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods." [GOC:ai, ISBN:0721662544] synonym: "pantothenate breakdown" EXACT [] synonym: "pantothenate catabolism" EXACT [] synonym: "pantothenate degradation" EXACT [] synonym: "vitamin B5 catabolic process" EXACT [] synonym: "vitamin B5 catabolism" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0015939 ! pantothenate metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0015942 name: formate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0015943 name: formate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid." [ISBN:0198506732] synonym: "formate anabolism" EXACT [] synonym: "formate biosynthesis" EXACT [] synonym: "formate formation" EXACT [] synonym: "formate synthesis" EXACT [] synonym: "formic acid biosynthesis" EXACT [] synonym: "formic acid biosynthetic process" EXACT [] is_a: GO:0015942 ! formate metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0015944 name: formate oxidation namespace: biological_process def: "The chemical reactions and pathways by which formate is converted to CO2." [MetaCyc:PWY-1881] synonym: "formic acid oxidation" EXACT [] xref: MetaCyc:PWY-1881 is_a: GO:0015942 ! formate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015945 name: methanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanol, CH3-OH, a colorless, flammable, mobile, poisonous liquid, widely used as a solvent." [GOC:go_curators, ISBN:0198506732] synonym: "methanol metabolism" EXACT [] is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0015946 name: methanol oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of methanol to methyl-Coenzyme M." [MetaCyc:CO2FORM-PWY] xref: MetaCyc:CO2FORM-PWY is_a: GO:0015945 ! methanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015947 name: methane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [ISBN:0198506732] synonym: "methane metabolism" EXACT [] is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0015948 name: methanogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4. It is the simplest of the alkanes." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir synonym: "methane biosynthesis" EXACT [] synonym: "methane biosynthetic process" EXACT [] xref: UM-BBD_pathwayID:meth xref: Wikipedia:Methanogenesis is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015947 ! methane metabolic process is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0043447 ! alkane biosynthetic process [Term] id: GO:0015949 name: nucleobase-containing small molecule interconversion namespace: biological_process def: "The chemical reactions and pathways by which a nucleobase, nucleoside or nucleotide small molecule is synthesized from another nucleobase, nucleoside or nucleotide small molecule." [GOC:mah, ISBN:0306444747, ISBN:0471394831] subset: goslim_pir xref: MetaCyc:P1-PWY is_a: GO:0055086 ! nucleobase-containing small molecule metabolic process [Term] id: GO:0015950 name: purine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleotide is synthesized from another purine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0015951 name: purine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine ribonucleotide is synthesized from another purine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015952 name: purine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleotide is synthesized from another purine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0015950 ! purine nucleotide interconversion [Term] id: GO:0015953 name: pyrimidine nucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleotide is synthesized from another pyrimidine nucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0015954 name: pyrimidine ribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine ribonucleotide is synthesized from another pyrimidine ribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015955 name: pyrimidine deoxyribonucleotide interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleotide is synthesized from another pyrimidine deoxyribonucleotide." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0015953 ! pyrimidine nucleotide interconversion [Term] id: GO:0015956 name: bis(5'-nucleosidyl) oligophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0015957 name: bis(5'-nucleosidyl) oligophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate anabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate biosynthesis" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate formation" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process [Term] id: GO:0015958 name: bis(5'-nucleosidyl) oligophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a bis(5'-nucleosidyl) oligophosphate, a compound formed of two nucleosides joined together through their 5' carbons by a chain of phosphate molecules." [GOC:mah, PMID:10970777] synonym: "bis(5'-nucleosidyl) oligophosphate breakdown" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate catabolism" EXACT [] synonym: "bis(5'-nucleosidyl) oligophosphate degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0015956 ! bis(5'-nucleosidyl) oligophosphate metabolic process [Term] id: GO:0015959 name: diadenosine polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0015960 name: diadenosine polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate anabolism" EXACT [] synonym: "diadenosine polyphosphate biosynthesis" EXACT [] synonym: "diadenosine polyphosphate formation" EXACT [] synonym: "diadenosine polyphosphate synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015961 name: diadenosine polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine polyphosphate, a derivative of the nucleoside adenosine with phosphate groups attached." [GOC:ai] synonym: "diadenosine polyphosphate breakdown" EXACT [] synonym: "diadenosine polyphosphate catabolism" EXACT [] synonym: "diadenosine polyphosphate degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015962 name: diadenosine triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015963 name: diadenosine triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate anabolism" EXACT [] synonym: "diadenosine triphosphate biosynthesis" EXACT [] synonym: "diadenosine triphosphate formation" EXACT [] synonym: "diadenosine triphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015964 name: diadenosine triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine triphosphate, a derivative of the nucleoside adenosine with three phosphate groups attached." [GOC:ai] synonym: "diadenosine triphosphate breakdown" EXACT [] synonym: "diadenosine triphosphate catabolism" EXACT [] synonym: "diadenosine triphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015962 ! diadenosine triphosphate metabolic process [Term] id: GO:0015965 name: diadenosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate metabolism" EXACT [] is_a: GO:0015959 ! diadenosine polyphosphate metabolic process [Term] id: GO:0015966 name: diadenosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate anabolism" EXACT [] synonym: "diadenosine tetraphosphate biosynthesis" EXACT [] synonym: "diadenosine tetraphosphate formation" EXACT [] synonym: "diadenosine tetraphosphate synthesis" EXACT [] is_a: GO:0015960 ! diadenosine polyphosphate biosynthetic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015967 name: diadenosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diadenosine tetraphosphate, a derivative of the nucleoside adenosine with four phosphate groups attached." [GOC:ai] synonym: "diadenosine tetraphosphate breakdown" EXACT [] synonym: "diadenosine tetraphosphate catabolism" EXACT [] synonym: "diadenosine tetraphosphate degradation" EXACT [] is_a: GO:0015961 ! diadenosine polyphosphate catabolic process is_a: GO:0015965 ! diadenosine tetraphosphate metabolic process [Term] id: GO:0015968 name: stringent response namespace: biological_process def: "A specific global change in the metabolism of a bacterial cell (the downregulation of nucleic acid and protein synthesis, and the simultaneous upregulation of protein degradation and amino acid synthesis) as a result of starvation." [GOC:jl, ISBN:0124325653, PMID:11282471] xref: Wikipedia:Stringent_response is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0015969 name: guanosine tetraphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') metabolism" EXACT [] synonym: "guanosine tetraphosphate metabolism" EXACT [] xref: MetaCyc:PPGPPMET-PWY is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0015970 name: guanosine tetraphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthesis" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine tetraphosphate anabolism" EXACT [] synonym: "guanosine tetraphosphate biosynthesis" EXACT [] synonym: "guanosine tetraphosphate formation" EXACT [] synonym: "guanosine tetraphosphate synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0015971 name: guanosine tetraphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates." [GOC:ai] synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolic process" EXACT [] synonym: "guanosine tetraphosphate (5'-ppGpp-3') catabolism" EXACT [] synonym: "guanosine tetraphosphate breakdown" EXACT [] synonym: "guanosine tetraphosphate catabolism" EXACT [] synonym: "guanosine tetraphosphate degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015969 ! guanosine tetraphosphate metabolic process is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0015972 name: guanosine pentaphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') metabolism" EXACT [] synonym: "guanosine pentaphosphate metabolism" EXACT [] is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0034035 ! purine ribonucleoside bisphosphate metabolic process is_a: GO:1901068 ! guanosine-containing compound metabolic process [Term] id: GO:0015973 name: guanosine pentaphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthesis" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') biosynthetic process" EXACT [] synonym: "guanosine pentaphosphate anabolism" EXACT [] synonym: "guanosine pentaphosphate biosynthesis" EXACT [] synonym: "guanosine pentaphosphate formation" EXACT [] synonym: "guanosine pentaphosphate synthesis" EXACT [] is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process is_a: GO:0034036 ! purine ribonucleoside bisphosphate biosynthetic process is_a: GO:1901070 ! guanosine-containing compound biosynthetic process [Term] id: GO:0015974 name: guanosine pentaphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates." [GOC:ai] synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolic process" EXACT [] synonym: "guanosine pentaphosphate (5'-pppGpp-3') catabolism" EXACT [] synonym: "guanosine pentaphosphate breakdown" EXACT [] synonym: "guanosine pentaphosphate catabolism" EXACT [] synonym: "guanosine pentaphosphate degradation" EXACT [] is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0015972 ! guanosine pentaphosphate metabolic process is_a: GO:0034037 ! purine ribonucleoside bisphosphate catabolic process is_a: GO:1901069 ! guanosine-containing compound catabolic process [Term] id: GO:0015975 name: energy derivation by oxidation of reduced inorganic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from inorganic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemolithotrophie" EXACT [] synonym: "chemolithotrophy" EXACT [] synonym: "lithotrophy" EXACT [Wikipedia:Lithotrophy] xref: Wikipedia:Lithotrophy is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015976 name: carbon utilization namespace: biological_process alt_id: GO:0015978 def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbon sources and then activates genes to scavenge the last traces of the primary carbon source and to transport and metabolize alternative carbon sources such as carbon dioxide or carbonic acid. The utilization process begins when the cell or organism detects carbon levels, includes the activation of genes whose products detect, transport or metabolize carbon-containing substances, and ends when carbon is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: goslim_chembl subset: goslim_pir synonym: "carbon utilization by utilization of organic compounds" EXACT [GOC:mah] synonym: "heterotrophy" EXACT [] xref: Wikipedia:Heterotroph is_a: GO:0008150 ! biological_process [Term] id: GO:0015977 name: carbon fixation namespace: biological_process def: "A metabolic process in which carbon (usually derived from carbon dioxide) is incorporated into organic compounds (usually carbohydrates)." [GOC:jl, GOC:mah] synonym: "autotrophic CO2 fixation" EXACT [] synonym: "autotrophic CO2 fixation pathway" EXACT [] synonym: "autotrophy" EXACT [] synonym: "carbon dioxide fixation" NARROW [] xref: Wikipedia:Carbon_fixation is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0015979 name: photosynthesis namespace: biological_process def: "The synthesis by organisms of organic chemical compounds, especially carbohydrates, from carbon dioxide (CO2) using energy obtained from light rather than from the oxidation of chemical compounds." [ISBN:0198547684] subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant xref: Wikipedia:Photosynthesis is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0015980 name: energy derivation by oxidation of organic compounds namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from organic compounds; results in the oxidation of the compounds from which energy is released." [GOC:mah] synonym: "chemoorganotrophy" EXACT [] is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0015981 name: obsolete passive proton transport, down the electrochemical gradient namespace: biological_process def: "OBSOLETE. The passive movement of protons from areas of high proton concentration and electrical potential to areas where concentration and electrical potential are low." [ISBN:0716731363] comment: This term was made obsolete because it represents a passive process which occurs without the aid of gene products. synonym: "passive proton transport, down the electrochemical gradient" EXACT [] is_obsolete: true consider: GO:1902600 [Term] id: GO:0015982 name: obsolete antiport namespace: biological_process def: "OBSOLETE. The process of coupled solute translocation in which two solutes equilibrate across an osmotic barrier, the translocation of solute being coupled to the translocation of the other in the opposite direction." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "antiport" EXACT [] is_obsolete: true replaced_by: GO:0015297 [Term] id: GO:0015983 name: obsolete symport namespace: biological_process def: "OBSOLETE. The process of solute translocation in which two solutes equilibrate across an osmotic barrier, and the translocation of one solute is coupled to the translocation of the other in the same direction." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "symport" EXACT [] is_obsolete: true replaced_by: GO:0015293 [Term] id: GO:0015984 name: obsolete uniport namespace: biological_process def: "OBSOLETE. The process of noncoupled solute translocation or facilitated diffusion." [ISBN:0198506732] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "uniport" EXACT [] is_obsolete: true replaced_by: GO:0015292 [Term] id: GO:0015985 name: energy coupled proton transport, down electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that provides energy for the synthesis of ATP or GTP." [GOC:mah] is_a: GO:1902600 ! proton transmembrane transport [Term] id: GO:0015986 name: ATP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers ATP synthesis." [ISBN:0716731363] synonym: "chemiosmosis" BROAD [GOC:rs] is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015987 name: GTP synthesis coupled proton transport namespace: biological_process def: "The transport of protons across a membrane to generate an electrochemical gradient (proton-motive force) that powers GTP synthesis." [ISBN:0716731363] is_a: GO:0015985 ! energy coupled proton transport, down electrochemical gradient [Term] id: GO:0015988 name: energy coupled proton transmembrane transport, against electrochemical gradient namespace: biological_process def: "The transport of protons across a membrane and against an electrochemical gradient, using energy from a source such as ATP hydrolysis, light, or electron transport." [GOC:mah] is_a: GO:1902600 ! proton transmembrane transport [Term] id: GO:0015989 name: light-driven proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from light." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient [Term] id: GO:0015990 name: electron transport coupled proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from electron transport." [GOC:mah] is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient [Term] id: GO:0015991 name: ATP hydrolysis coupled proton transport namespace: biological_process def: "The transport of protons against an electrochemical gradient, using energy from ATP hydrolysis." [GOC:mah, GOC:vw] is_a: GO:0015988 ! energy coupled proton transmembrane transport, against electrochemical gradient is_a: GO:0099131 ! ATP hydrolysis coupled ion transmembrane transport is_a: GO:0099132 ! ATP hydrolysis coupled cation transmembrane transport [Term] id: GO:0015993 name: obsolete molecular hydrogen transport namespace: biological_process def: "OBSOLETE. The directed movement of molecular hydrogen (H2) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:jl] comment: The reason for obsoletion is that there molecular hydrogen (H2) diffuses passively through membranes (see https://www.researchgate.net/post/How_molecular_hydrogen_is_transported_through_the_cytoplasmic_membrane_of_Escherichia_coli). is_obsolete: true [Term] id: GO:0015994 name: chlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] synonym: "chlorophyll metabolism" EXACT [] is_a: GO:0006778 ! porphyrin-containing compound metabolic process [Term] id: GO:0015995 name: chlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [GOC:jl] synonym: "chlorophyll anabolism" EXACT [] synonym: "chlorophyll biosynthesis" EXACT [] synonym: "chlorophyll formation" EXACT [] synonym: "chlorophyll synthesis" EXACT [] xref: MetaCyc:CHLOROPHYLL-SYN is_a: GO:0006779 ! porphyrin-containing compound biosynthetic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0015996 name: chlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, into less complex products." [GOC:jl] synonym: "chlorophyll breakdown" EXACT [] synonym: "chlorophyll catabolism" EXACT [] synonym: "chlorophyll degradation" EXACT [] is_a: GO:0006787 ! porphyrin-containing compound catabolic process is_a: GO:0015994 ! chlorophyll metabolic process is_a: GO:0046149 ! pigment catabolic process [Term] id: GO:0015997 name: obsolete ubiquinone biosynthetic process monooxygenase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates biological process information. synonym: "coenzyme Q biosynthesis monooxygenase activity" EXACT [] synonym: "coenzyme Q biosynthetic process monooxygenase activity" EXACT [] synonym: "ubiquinone anabolism monooxygenase activity" EXACT [] synonym: "ubiquinone biosynthetic process monooxygenase activity" EXACT [] synonym: "ubiquinone formation monooxygenase activity" EXACT [] synonym: "ubiquinone synthesis monooxygenase activity" EXACT [] is_obsolete: true [Term] id: GO:0016002 name: sulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: hydrogen sulfide + acceptor + 3 H2O = sulfite + reduced acceptor." [EC:1.8.99.1] synonym: "assimilatory sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "assimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "hydrogen-sulfide:acceptor oxidoreductase activity" EXACT [EC:1.8.99.1] synonym: "siroheme sulfite reductase activity" NARROW [MetaCyc:SULFITE-REDUCTASE-RXN] synonym: "sulphite reductase activity" EXACT [] xref: EC:1.8.99.1 xref: MetaCyc:SULFITE-REDUCTASE-RXN xref: RHEA:10547 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016004 name: phospholipase activator activity namespace: molecular_function def: "Increases the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a glycerophospholipid." [GOC:ai] is_a: GO:0060229 ! lipase activator activity [Term] id: GO:0016005 name: phospholipase A2 activator activity namespace: molecular_function def: "Increases the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0016004 ! phospholipase activator activity [Term] id: GO:0016006 name: Nebenkern namespace: cellular_component def: "A product of the fusion of the mitochondria during spermatogenesis. After the completion of meiosis the mitochondria of the spermatid collect along side the nucleus and fuse into two masses; these wrap around each other to produce the spherical Nebenkern. During flagellum elongation the Nebenkern unfolds and the two derivatives (major and minor mitochondrial derivatives) elongate down the axoneme." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016007 name: mitochondrial derivative namespace: cellular_component def: "The major and minor mitochondrial derivatives are the mitochondria of the sperm tail and derive by the unfolding of the Nebenkern during flagellum elongation." [GOC:ma] is_a: GO:0005739 ! mitochondrion [Term] id: GO:0016008 name: major mitochondrial derivative namespace: cellular_component def: "The larger of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation; the major mitochondrial derivative is ovoid and darker than the minor derivative." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016009 name: minor mitochondrial derivative namespace: cellular_component def: "The smaller of the two mitochondrial derivatives that arise by the unfolding of the Nebenkern during flagellum elongation." [GOC:mah, PMID:17123504] is_a: GO:0016007 ! mitochondrial derivative [Term] id: GO:0016010 name: dystrophin-associated glycoprotein complex namespace: cellular_component def: "A multiprotein complex that forms a strong mechanical link between the cytoskeleton and extracellular matrix; typical of, but not confined to, muscle cells. The complex is composed of transmembrane, cytoplasmic, and extracellular proteins, including dystrophin, sarcoglycans, dystroglycan, dystrobrevins, syntrophins, sarcospan, caveolin-3, and NO synthase." [PMID:15117830, PMID:16710609] subset: goslim_pir synonym: "DGC" EXACT [] synonym: "dystrophin glycoprotein complex" EXACT [] is_a: GO:0090665 ! glycoprotein complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0016011 name: dystroglycan complex namespace: cellular_component def: "A protein complex that includes alpha- and beta-dystroglycan, which are alternative products of the same gene; the laminin-binding component of the dystrophin-associated glycoprotein complex, providing a link between the subsarcolemmal cytoskeleton (in muscle cells) and the extracellular matrix. Alpha-dystroglycan is an extracellular protein binding to alpha-laminin and to beta-dystroglycan; beta-dystroglycan is a transmembrane protein which binds alpha-dystroglycan and dystrophin." [PMID:15117830, PMID:16710609] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016012 name: sarcoglycan complex namespace: cellular_component def: "A protein complex formed of four sarcoglycans plus sarcospan; there are six known sarcoglycans: alpha-, beta-, gamma-, delta-, epsilon- and zeta-sarcoglycan; all are N-glycosylated single-pass transmembrane proteins. The sarcoglycan-sarcospan complex is a subcomplex of the dystrophin glycoprotein complex, and is fixed to the dystrophin axis by a lateral association with the dystroglycan complex." [PMID:15117830, PMID:16710609] synonym: "sarcoglycan-sarcospan complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016011 ! dystroglycan complex [Term] id: GO:0016013 name: syntrophin complex namespace: cellular_component def: "A protein complex that includes alpha-, beta1-, beta2-syntrophins and syntrophin-like proteins; the syntrophin complex binds to the second half of the carboxy-terminal domain of dystrophin; also associates with neuronal nitric oxide synthase." [http://www.dmd.nl/DGC.html#syn] synonym: "nitric oxide synthase-dystrophin complex, skeletal muscle" RELATED [CORUM:416] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016014 name: dystrobrevin complex namespace: cellular_component def: "A protein complex comprising alpha- and beta-dystrobrevin; forms part of the dystrophin glycoprotein complex." [PMID:15117830, PMID:16710609] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0016010 ! dystrophin-associated glycoprotein complex [Term] id: GO:0016015 name: morphogen activity namespace: molecular_function def: "Acts as a trigger for a pattern specification process when present at a specific concentration within a gradient." [GOC:go_curators] is_a: GO:0048018 ! receptor ligand activity [Term] id: GO:0016016 name: obsolete short-wave-sensitive opsin namespace: molecular_function def: "OBSOLETE. An opsin with maximal absorption between 400 and 500 nm." [PMID:10594055] comment: This term was made obsolete because it refers to a class of proteins. synonym: "short-wave-sensitive opsin" EXACT [] is_obsolete: true consider: GO:0007603 consider: GO:0009588 consider: GO:0009881 consider: GO:0016021 consider: GO:0016918 consider: GO:0046876 [Term] id: GO:0016018 name: cyclosporin A binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclosporin A, a cyclic undecapeptide that contains several N-methylated and unusual amino acids." [GOC:mb] synonym: "cyclophilin" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0016019 name: peptidoglycan receptor activity namespace: molecular_function def: "Combining with a peptidoglycan and transmitting the signal to initiate a change in cell activity." [PMID:14698226] comment: Note that only peptidoglycan recognition proteins with receptor activity should be annotated to this term; otherwise use 'peptidoglycan binding ; GO:0042834' instead. synonym: "peptidoglycan recognition activity" NARROW [] is_a: GO:0008329 ! signaling pattern recognition receptor activity [Term] id: GO:0016020 name: membrane namespace: cellular_component def: "A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it." [GOC:dos, GOC:mah, ISBN:0815316194] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: Wikipedia:Biological_membrane is_a: GO:0005575 ! cellular_component [Term] id: GO:0016021 name: integral component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_chembl synonym: "integral to membrane" NARROW [] synonym: "transmembrane" RELATED [GOC:mah] xref: Wikipedia:Transmembrane_protein is_a: GO:0031224 ! intrinsic component of membrane [Term] id: GO:0016024 name: CDP-diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CDP-diacylglycerol, CDP-1,2-diacylglycerol, a substance composed of diacylglycerol in glycosidic linkage with cytidine diphosphate." [CHEBI:17962, GOC:curators] synonym: "CDP-diacylglycerol anabolism" EXACT [] synonym: "CDP-diacylglycerol biosynthesis" EXACT [] synonym: "CDP-diacylglycerol formation" EXACT [] synonym: "CDP-diacylglycerol synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0046341 ! CDP-diacylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0016025 name: obsolete proteasome endopeptidase regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "proteasome endopeptidase regulator" EXACT [] is_obsolete: true consider: GO:0004175 [Term] id: GO:0016026 name: obsolete proteasome endopeptidase core namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. synonym: "proteasome endopeptidase core" EXACT [] is_obsolete: true consider: GO:0004175 [Term] id: GO:0016027 name: inaD signaling complex namespace: cellular_component def: "A complex of proteins that are involved in phototransduction and attached to the transient receptor potential (TRP) channel. The protein connections are mediated through inaD." [GOC:hb, PMID:9010208, PMID:9796815] synonym: "inaD signalling complex" EXACT [] is_a: GO:0098797 ! plasma membrane protein complex is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0016028 ! rhabdomere relationship: part_of GO:0019897 ! extrinsic component of plasma membrane [Term] id: GO:0016028 name: rhabdomere namespace: cellular_component def: "The specialized microvilli-containing organelle on the apical surfaces of a photoreceptor cell containing the visual pigment rhodopsin and most of the proteins involved in phototransduction." [GOC:hb, GOC:sart, PMID:8646774] subset: goslim_pir is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0016029 name: subrhabdomeral cisterna namespace: cellular_component def: "A membrane-bounded compartment that is found at the base of the rhabdomere and contains stored calcium, InsP3 receptors and smooth endoplasmic reticulum Ca2+-ATPase." [PMID:11707492, PMID:8646774] synonym: "SMC" RELATED [] synonym: "submicrovillar cisterna" EXACT [PMID:11707492] is_a: GO:0098827 ! endoplasmic reticulum subcompartment is_a: GO:0120038 ! plasma membrane bounded cell projection part is_a: GO:0120082 ! smooth endoplasmic reticulum cisterna relationship: part_of GO:0016028 ! rhabdomere [Term] id: GO:0016031 name: tRNA import into mitochondrion namespace: biological_process def: "The process in which a tRNA is transported from the cytosol, into the mitochondrial matrix." [GOC:ma, PMID:10988073, PMID:11121736] synonym: "cytoplasmic tRNA import into mitochondria" EXACT [] synonym: "cytoplasmic tRNA import into mitochondrion" NARROW [GOC:bf] synonym: "cytoplasmic tRNA transport into mitochondrion" EXACT [] synonym: "cytoplasmic tRNA, mitochondrial import" EXACT [] synonym: "mitochondrial import of cytoplasmic tRNA" NARROW [] synonym: "nuclear-encoded tRNA import into mitochondrion" NARROW [GOC:bf] is_a: GO:0035927 ! RNA import into mitochondrion is_a: GO:0051031 ! tRNA transport [Term] id: GO:0016032 name: viral process namespace: biological_process alt_id: GO:0022415 def: "A multi-organism process in which a virus is a participant. The other participant is the host. Includes infection of a host cell, replication of the viral genome, and assembly of progeny virus particles. In some cases the viral genetic material may integrate into the host genome and only subsequently, under particular circumstances, 'complete' its life cycle." [GOC:bf, GOC:jl, GOC:mah] comment: See also the biological process terms 'viral infectious cycle ; GO:0019058' and 'lysogeny ; GO:0030069'. subset: goslim_metagenomics subset: goslim_pir synonym: "viral infection" RELATED [] synonym: "virulence" RELATED [] synonym: "virus process" EXACT [GOC:bf, GOC:jl] xref: Wikipedia:Viral_life_cycle is_a: GO:0044403 ! symbiont process [Term] id: GO:0016034 name: maleylacetoacetate isomerase activity namespace: molecular_function alt_id: GO:0018841 def: "Catalysis of the reaction: 4-maleylacetoacetate = 4-fumarylacetoacetate." [EC:5.2.1.2] synonym: "4-maleylacetoacetate cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetoacetic isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone cis-trans-isomerase activity" EXACT [EC:5.2.1.2] synonym: "maleylacetone isomerase activity" EXACT [EC:5.2.1.2] xref: EC:5.2.1.2 xref: MetaCyc:MALEYLACETOACETATE-ISOMERASE-RXN xref: reactome:R-HSA-71173 "maleylacetoacetate => fumarylacetoacetate" xref: RHEA:14817 xref: UM-BBD_reactionID:r0106 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0016035 name: zeta DNA polymerase complex namespace: cellular_component def: "A heterodimeric DNA polymerase complex that catalyzes error-prone DNA synthesis in contexts such as translesion synthesis and double-stranded break repair. First characterized in Saccharomyces, in which the subunits are Rev3p and Rev7p; a third protein, Rev1p, is often associated with the polymerase dimer." [PMID:16631579, PMID:16971464] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044446 ! intracellular organelle part [Term] id: GO:0016036 name: cellular response to phosphate starvation namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate." [GOC:jl] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0016037 name: light absorption namespace: biological_process def: "The reception of a photon by a cell." [GOC:go_curators] synonym: "absorption of light" EXACT [GOC:curators] is_a: GO:0009987 ! cellular process relationship: part_of GO:0009583 ! detection of light stimulus [Term] id: GO:0016038 name: absorption of visible light namespace: biological_process def: "The reception of a (visible light) photon by a cell, visible light being defined as having a wavelength within the range 380-780 nm." [GOC:go_curators, ISBN:0198506732] is_a: GO:0016037 ! light absorption [Term] id: GO:0016039 name: absorption of UV light namespace: biological_process def: "The reception of a (UV light) photon by a cell, UV light being defined as having a wavelength within the range 13.6-400 nm." [GOC:go_curators, ISBN:0198506732] is_a: GO:0016037 ! light absorption [Term] id: GO:0016040 name: glutamate synthase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NAD(+) = 2-oxoglutarate + L-glutamine + H(+) + NADH." [EC:1.4.1.14, RHEA:13753] synonym: "glutamate (reduced nicotinamide adenine dinucleotide) synthase" EXACT [EC:1.4.1.14] synonym: "GOGAT activity" BROAD [] synonym: "L-glutamate synthase (NADH)" EXACT [EC:1.4.1.14] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.14] synonym: "L-glutamate:NAD+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.14] synonym: "NADH-dependent glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH-glutamate synthase activity" EXACT [EC:1.4.1.14] synonym: "NADH: GOGAT" EXACT [EC:1.4.1.14] xref: EC:1.4.1.14 xref: KEGG:R00093 xref: MetaCyc:GLUTAMATE-SYNTHASE-NADH-RXN xref: RHEA:13753 is_a: GO:0045181 ! glutamate synthase activity, NAD(P)H as acceptor [Term] id: GO:0016041 name: glutamate synthase (ferredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + 2 oxidized ferredoxin = L-glutamine + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+. This is a two-step reaction: (a) L-glutamate + NH3 = L-glutamine + H2O, (b) L-glutamate + 2 oxidized ferredoxin + H2O = NH3 + 2-oxoglutarate + 2 reduced ferredoxin + 2 H+." [EC:1.4.7.1] synonym: "ferredoxin-dependent glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "ferredoxin-glutamate synthase activity" EXACT [EC:1.4.7.1] synonym: "glutamate synthase (ferredoxin-dependent)" EXACT [EC:1.4.7.1] synonym: "L-glutamate:ferredoxin oxidoreductase (transaminating)" EXACT [EC:1.4.7.1] xref: EC:1.4.7.1 xref: MetaCyc:GLUTAMATE-SYNTHASE-FERREDOXIN-RXN xref: MetaCyc:PWY-4341 is_a: GO:0015930 ! glutamate synthase activity is_a: GO:0016643 ! oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor [Term] id: GO:0016042 name: lipid catabolic process namespace: biological_process alt_id: GO:0006724 alt_id: GO:0044240 def: "The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] synonym: "lipid breakdown" EXACT [] synonym: "lipid catabolism" EXACT [] synonym: "lipid degradation" EXACT [] synonym: "lipolysis" EXACT [] synonym: "multicellular organism lipid catabolic process" NARROW [] synonym: "multicellular organismal lipid catabolic process" NARROW [] xref: Wikipedia:Lipid_catabolism is_a: GO:0006629 ! lipid metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0016043 name: cellular component organization namespace: biological_process alt_id: GO:0044235 alt_id: GO:0071842 def: "A process that results in the assembly, arrangement of constituent parts, or disassembly of a cellular component." [GOC:ai, GOC:jl, GOC:mah] subset: goslim_agr subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "cell organisation" EXACT [] synonym: "cell organization and biogenesis" RELATED [GOC:mah] synonym: "cellular component organisation at cellular level" EXACT [GOC:mah] synonym: "cellular component organisation in other organism" EXACT [GOC:mah] synonym: "cellular component organization at cellular level" EXACT [] synonym: "cellular component organization in other organism" EXACT [] is_a: GO:0009987 ! cellular process is_a: GO:0071840 ! cellular component organization or biogenesis [Term] id: GO:0016045 name: detection of bacterium namespace: biological_process alt_id: GO:0009598 alt_id: GO:0009681 def: "The series of events in which a stimulus from a bacterium is received and converted into a molecular signal." [GOC:hb] synonym: "detection of bacteria" EXACT [] synonym: "perception of bacteria" RELATED [] synonym: "perception of bacterium" RELATED [] is_a: GO:0009617 ! response to bacterium is_a: GO:0098543 ! detection of other organism [Term] id: GO:0016046 name: detection of fungus namespace: biological_process alt_id: GO:0009599 def: "The series of events in which a stimulus from a fungus is received and converted into a molecular signal." [GOC:hb] synonym: "detection of fungi" EXACT [] synonym: "perception of fungi" RELATED [] synonym: "perception of fungus" RELATED [] is_a: GO:0009620 ! response to fungus is_a: GO:0098543 ! detection of other organism [Term] id: GO:0016047 name: detection of parasitic fungus namespace: biological_process def: "The series of events in which a stimulus from a parasitic fungus (a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection) is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732] synonym: "detection of parasitic fungi" EXACT [] synonym: "perception of parasitic fungi" RELATED [] synonym: "perception of parasitic fungus" RELATED [] is_a: GO:0009603 ! detection of symbiotic fungus is_a: GO:0009623 ! response to parasitic fungus [Term] id: GO:0016048 name: detection of temperature stimulus namespace: biological_process def: "The series of events in which a temperature stimulus (hot or cold) is received and converted into a molecular signal." [GOC:hb] synonym: "detection of temperature" EXACT [] synonym: "detection of thermal stimulus" EXACT [] synonym: "perception of temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0016049 name: cell growth namespace: biological_process alt_id: GO:0048591 def: "The process in which a cell irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:ai] subset: gocheck_do_not_annotate subset: goslim_pir subset: goslim_plant synonym: "cell expansion" RELATED [] synonym: "cellular growth" EXACT [] synonym: "growth of cell" EXACT [] synonym: "metabolic process resulting in cell growth" RELATED [] synonym: "metabolism resulting in cell growth" RELATED [] synonym: "non-developmental cell growth" RELATED [GOC:mah] synonym: "non-developmental growth of a unicellular organism" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0040007 ! growth [Term] id: GO:0016050 name: vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle." [GOC:mah] subset: goslim_pir subset: goslim_yeast synonym: "vesicle organisation" EXACT [GOC:curators] synonym: "vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0016051 name: carbohydrate biosynthetic process namespace: biological_process alt_id: GO:0006093 def: "The chemical reactions and pathways resulting in the formation of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "anabolic carbohydrate metabolic process" EXACT [] synonym: "anabolic carbohydrate metabolism" EXACT [] synonym: "carbohydrate anabolism" EXACT [] synonym: "carbohydrate biosynthesis" EXACT [] synonym: "carbohydrate formation" EXACT [] synonym: "carbohydrate synthesis" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0016052 name: carbohydrate catabolic process namespace: biological_process alt_id: GO:0006095 alt_id: GO:0044276 alt_id: GO:0044724 def: "The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y." [ISBN:0198506732] synonym: "carbohydrate breakdown" EXACT [] synonym: "carbohydrate catabolism" EXACT [] synonym: "carbohydrate degradation" EXACT [] synonym: "catabolic carbohydrate metabolic process" EXACT [] synonym: "catabolic carbohydrate metabolism" EXACT [] synonym: "multicellular organismal carbohydrate catabolic process" NARROW [] synonym: "single-organism carbohydrate catabolic process" RELATED [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0016053 name: organic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid anabolism" EXACT [] synonym: "organic acid biosynthesis" EXACT [] synonym: "organic acid formation" EXACT [] synonym: "organic acid synthesis" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0016054 name: organic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732] synonym: "organic acid breakdown" EXACT [] synonym: "organic acid catabolism" EXACT [] synonym: "organic acid degradation" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0016055 name: Wnt signaling pathway namespace: biological_process alt_id: GO:0007222 def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state." [GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled signaling pathway" EXACT [] synonym: "frizzled signalling pathway" EXACT [] synonym: "Wg signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wg signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signaling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wingless signalling pathway" EXACT [GOC:sart, PMID:8080429] synonym: "Wnt receptor signaling pathway" EXACT [GOC:signaling] synonym: "Wnt receptor signalling pathway" EXACT [] synonym: "Wnt-activated signaling pathway" RELATED [] is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0198738 ! cell-cell signaling by wnt [Term] id: GO:0016056 name: rhodopsin mediated signaling pathway namespace: biological_process alt_id: GO:0009586 def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events that convert the absorbed photons into a cellular response." [GOC:bf, GOC:dph, GOC:hb, GOC:signaling, GOC:tb] synonym: "rhodopsin mediated phototransduction" EXACT [GOC:bf] synonym: "rhodopsin mediated signalling pathway" EXACT [GOC:dph, GOC:tb] synonym: "rhodopsin signaling" EXACT [GOC:bf] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway is_a: GO:0007602 ! phototransduction is_a: GO:0071482 ! cellular response to light stimulus relationship: part_of GO:0007603 ! phototransduction, visible light [Term] id: GO:0016057 name: regulation of membrane potential in photoreceptor cell namespace: biological_process def: "Hyperpolarization (vertebrates) or depolarization (invertebrates) of the photoreceptor cell membrane via closing/opening of cation specific channels as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "changes in polarization state of photoreceptor cell membrane" EXACT [GOC:dph, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0016058 name: maintenance of membrane potential in photoreceptor cell by rhodopsin mediated signaling namespace: biological_process def: "Maintenance of the excited state of a photoreceptor cell to produce a steady-state current as a result of signals generated by rhodopsin activation by a photon." [GOC:dph, GOC:hb, GOC:tb] synonym: "maintenance of rhodopsin mediated signaling" RELATED [] synonym: "maintenance of rhodopsin mediated signalling" EXACT [] is_a: GO:0016057 ! regulation of membrane potential in photoreceptor cell [Term] id: GO:0016059 name: deactivation of rhodopsin mediated signaling namespace: biological_process def: "The process of restoring the photoreceptor cell to its unexcited state after termination of the stimulus (photon)." [PMID:8316831] synonym: "deactivation of rhodopsin mediated signalling" EXACT [] synonym: "rod response recovery" BROAD [GOC:bf] is_a: GO:0022400 ! regulation of rhodopsin mediated signaling pathway [Term] id: GO:0016060 name: metarhodopsin inactivation namespace: biological_process def: "The process in which metarhodopsin is prevented from generating molecular signals. Activated rhodopsin (R*) is inactivated by a two-step process: first, R* is phosphorylated by rhodopsin kinase which lowers the activity of R*. Second, the protein arrestin binds to phosphorylated R* to de-activate it." [GOC:hb, Wikipedia:Visual_phototransduction] is_a: GO:0009968 ! negative regulation of signal transduction relationship: part_of GO:0016059 ! deactivation of rhodopsin mediated signaling [Term] id: GO:0016061 name: regulation of light-activated channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated channel activity." [GOC:go_curators] is_a: GO:0032412 ! regulation of ion transmembrane transporter activity [Term] id: GO:0016062 name: adaptation of rhodopsin mediated signaling namespace: biological_process def: "The process in which a rhodopsin-mediated signaling pathway is adjusted to modulate the sensitivity and response of a visual system to light stimuli (that might vary over more than 6 magnitudes in intensity) without response saturation." [PMID:1962207] synonym: "adaptation of rhodopsin mediated signalling" EXACT [] is_a: GO:0023058 ! adaptation of signaling pathway relationship: part_of GO:0016056 ! rhodopsin mediated signaling pathway relationship: part_of GO:0036367 ! light adaption [Term] id: GO:0016063 name: rhodopsin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhodopsin, a brilliant purplish-red, light-sensitive visual pigment found in the rod cells of the retinas." [ISBN:0198506732] synonym: "rhodopsin anabolism" EXACT [] synonym: "rhodopsin biosynthesis" EXACT [] synonym: "rhodopsin formation" EXACT [] synonym: "rhodopsin synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046154 ! rhodopsin metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0016064 name: immunoglobulin mediated immune response namespace: biological_process def: "An immune response mediated by immunoglobulins, whether cell-bound or in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antibody-mediated immune response" EXACT [] is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0016065 name: obsolete humoral defense mechanism (sensu Protostomia) namespace: biological_process def: "OBSOLETE. The specific immune response mediated by antibodies. As in, but not restricted to, the taxon Protostomia (Protostomia, ncbi_taxonomy_id:33317)." [GOC:add, GOC:jid] comment: This term was made obsolete because antibodies are not found in the taxon Protostomia. synonym: "humoral defence mechanism (sensu Protostomia)" EXACT [] synonym: "humoral defense mechanism (sensu Protostomia)" EXACT [] is_obsolete: true [Term] id: GO:0016068 name: type I hypersensitivity namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells or basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149] comment: Note that localized and systemic anaphylaxis is usually a result of type I hypersensitivity. synonym: "immediate hypersensitivity response" EXACT [] xref: Wikipedia:Type_I_hypersensitivity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0016070 name: RNA metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_metagenomics subset: goslim_pir synonym: "RNA metabolism" EXACT [] is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0016071 name: mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732] subset: goslim_pombe synonym: "mRNA metabolism" EXACT [] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0016072 name: rRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rRNA, ribosomal RNA, a structural constituent of ribosomes." [ISBN:0198506732] synonym: "rRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016073 name: snRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snRNA, small nuclear RNA, any of various low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] subset: goslim_pombe synonym: "snRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016074 name: snoRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins. They participate in the processing or modifications of many RNAs, mostly ribosomal RNAs (rRNAs) though snoRNAs are also known to target other classes of RNA, including spliceosomal RNAs, tRNAs, and mRNAs via a stretch of sequence that is complementary to a sequence in the targeted RNA." [GOC:krc] subset: goslim_pombe synonym: "snoRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0016075 name: rRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rRNA, ribosomal RNA, a structural constituent of ribosomes." [GOC:ai] synonym: "rRNA breakdown" EXACT [] synonym: "rRNA catabolism" EXACT [] synonym: "rRNA degradation" EXACT [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016076 name: snRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snRNA, small nuclear RNA, low-molecular-mass RNA molecules found in the eukaryotic nucleus as components of the small nuclear ribonucleoprotein." [ISBN:0198506732] synonym: "snRNA breakdown" EXACT [] synonym: "snRNA catabolism" EXACT [] synonym: "snRNA degradation" EXACT [] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016077 name: snoRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of snoRNA, small nucleolar RNA, any of a class of small RNAs that are associated with the eukaryotic nucleus as components of small nucleolar ribonucleoproteins." [ISBN:0198506732] synonym: "snoRNA breakdown" EXACT [] synonym: "snoRNA catabolism" EXACT [] synonym: "snoRNA degradation" EXACT [] is_a: GO:0016074 ! snoRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016078 name: tRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis." [GOC:ai] synonym: "tRNA breakdown" EXACT [] synonym: "tRNA catabolism" EXACT [] synonym: "tRNA degradation" EXACT [] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034661 ! ncRNA catabolic process [Term] id: GO:0016079 name: synaptic vesicle exocytosis namespace: biological_process def: "Fusion of intracellular membrane-bounded vesicles with the pre-synaptic membrane of the neuronal cell resulting in release of neurotransmitter into the synaptic cleft." [GOC:jid, GOC:lmg] subset: goslim_synapse is_a: GO:0017156 ! calcium ion regulated exocytosis is_a: GO:0048489 ! synaptic vesicle transport is_a: GO:0099643 ! signal release from synapse relationship: part_of GO:0007269 ! neurotransmitter secretion relationship: part_of GO:0099504 ! synaptic vesicle cycle [Term] id: GO:0016080 name: synaptic vesicle targeting namespace: biological_process def: "The process in which synaptic vesicles are directed to specific destination membranes, mediated by molecules at the vesicle membrane and target membrane surfaces." [GOC:mah] is_a: GO:0006903 ! vesicle targeting is_a: GO:0140029 ! exocytic process relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016081 name: synaptic vesicle docking namespace: biological_process def: "The initial (indirect) attachment of a synaptic vesicle membrane to the presynaptic active zone membrane, mediated by proteins protruding from the membrane and proteins of the presynaptic active zone cytoplasmic component. Synaptic vesicle tethering is the first step in this process." [PMID:15217342] comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission (dos, pvn, fk synapse project 2015). subset: goslim_synapse synonym: "synaptic vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] synonym: "synaptic vesicle docking involved in exocytosis" EXACT [] is_a: GO:0006904 ! vesicle docking involved in exocytosis relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016082 name: synaptic vesicle priming namespace: biological_process def: "A process that converts synaptic vesicles to a state of competence for calcium triggered fusion with the active zone membrane by bringing the two membranes into very close proximity. Priming typically (but not always) occurs after docking (Jahn and Fasshauer, 2012). Primed vesicles are also capable of spontaneously fusing with the active zone membrane." [GOC:mah, PMID:15217342, PMID:23060190] comment: Although this process can occur outside of synaptic transmission, by convention we treat it as a part of synaptic transmission. (dos, pvn, fk synapse project 2015) subset: goslim_synapse is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0140029 ! exocytic process relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0016083 name: obsolete synaptic vesicle fusion namespace: biological_process def: "OBSOLETE. Fusion of the synaptic vesicle with the postsynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle fusion" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016084 name: myostimulatory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that stimulates muscle contraction." [GOC:mah, PMID:12204246] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016085 name: myoinhibitory hormone activity namespace: molecular_function def: "The action characteristic of myostimulatory hormone, a peptide hormone that inhibits muscle contraction." [GOC:mah, PMID:8902848] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016086 name: obsolete allatostatin namespace: molecular_function def: "OBSOLETE. Peptide hormones produced by the corpora allata of insects that reversibly inhibit the production of juvenile hormone." [GOC:ai, PMID:10891383] comment: This term was made obsolete because it refers to a gene product. synonym: "allatostatin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045968 [Term] id: GO:0016087 name: ecdysiostatic hormone activity namespace: molecular_function def: "The action characteristic of ecdysiostatic hormone, a peptide hormone that inhibits ecdysone secretion." [DOI:10.1002/(SICI)1520-6327(1997)35\:1, GOC:mah] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0016088 name: obsolete insulin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone that stimulates glucose uptake by muscle and adipose tissue, and promotes glycogenesis, lipogenesis and the synthesis of proteins and nucleic acids." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "insulin" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0045722 consider: GO:0045727 consider: GO:0045935 consider: GO:0046326 consider: GO:0046889 [Term] id: GO:0016090 name: prenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [ISBN:0198547684] synonym: "prenol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0016091 name: prenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] synonym: "prenol anabolism" EXACT [] synonym: "prenol biosynthesis" EXACT [] synonym: "prenol formation" EXACT [] synonym: "prenol synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0016090 ! prenol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0016092 name: prenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenols, isoprenoids of general formula (H-CH2-C(CH3)=CH-CH2-)n-OH, any primary monohydroxy alcohol whose carbon skeleton consists of two or more isoprenoid residues linked head to tail." [GOC:go_curators] synonym: "prenol breakdown" EXACT [] synonym: "prenol catabolism" EXACT [] synonym: "prenol degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0016090 ! prenol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0016093 name: polyprenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2, ISBN:0198547684] synonym: "polyprenol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0016094 name: polyprenol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] synonym: "polyprenol anabolism" EXACT [] synonym: "polyprenol biosynthesis" EXACT [] synonym: "polyprenol formation" EXACT [] synonym: "polyprenol synthesis" EXACT [] is_a: GO:0008299 ! isoprenoid biosynthetic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0016095 name: polyprenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyprenols, prenols with more than 4 isoprenoid residues, which may be all-trans, or a mixture of cis and trans." [GOC:go_curators, http://www.chem.qmul.ac.uk/iupac/misc/prenol.html#p2] synonym: "polyprenol breakdown" EXACT [] synonym: "polyprenol catabolism" EXACT [] synonym: "polyprenol degradation" EXACT [] is_a: GO:0008300 ! isoprenoid catabolic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0046164 ! alcohol catabolic process [Term] id: GO:0016098 name: monoterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409, ISBN:0198547684] synonym: "monoterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016099 name: monoterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] synonym: "monoterpenoid anabolism" EXACT [] synonym: "monoterpenoid biosynthesis" EXACT [] synonym: "monoterpenoid formation" EXACT [] synonym: "monoterpenoid synthesis" EXACT [] xref: MetaCyc:PWY-3041 is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016100 name: monoterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of monoterpenoid compounds, terpenoids having a C10 skeleton." [CHEBI:25409] synonym: "monoterpenoid breakdown" EXACT [] synonym: "monoterpenoid catabolism" EXACT [] synonym: "monoterpenoid degradation" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016101 name: diterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving diterpenoid compounds, terpenoids with four isoprene units." [ISBN:0198547684] synonym: "diterpene metabolic process" NARROW [] synonym: "diterpene metabolism" NARROW [] synonym: "diterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016102 name: diterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] synonym: "diterpene biosynthesis" NARROW [] synonym: "diterpene biosynthetic process" NARROW [] synonym: "diterpenoid anabolism" EXACT [] synonym: "diterpenoid biosynthesis" EXACT [] synonym: "diterpenoid formation" EXACT [] synonym: "diterpenoid synthesis" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016103 name: diterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of diterpenoid compounds, terpenoids with four isoprene units." [GOC:mah, ISBN:0198547684] synonym: "diterpene catabolic process" NARROW [] synonym: "diterpene catabolism" NARROW [] synonym: "diterpenoid breakdown" EXACT [] synonym: "diterpenoid catabolism" EXACT [] synonym: "diterpenoid degradation" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016104 name: triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] synonym: "triterpene biosynthesis" NARROW [] synonym: "triterpene biosynthetic process" NARROW [] synonym: "triterpenoid anabolism" EXACT [] synonym: "triterpenoid biosynthesis" EXACT [] synonym: "triterpenoid formation" EXACT [] synonym: "triterpenoid synthesis" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016105 name: triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of triterpenoid compounds, terpenoids with six isoprene units." [GOC:go_curators] synonym: "triterpene catabolic process" NARROW [] synonym: "triterpene catabolism" NARROW [] synonym: "triterpenoid breakdown" EXACT [] synonym: "triterpenoid catabolism" EXACT [] synonym: "triterpenoid degradation" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016106 name: sesquiterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid anabolism" EXACT [] synonym: "sesquiterpenoid biosynthesis" EXACT [] synonym: "sesquiterpenoid formation" EXACT [] synonym: "sesquiterpenoid synthesis" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016107 name: sesquiterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sesquiterpenoid compounds, terpenoids with three isoprene units." [GOC:go_curators] synonym: "sesquiterpenoid breakdown" EXACT [] synonym: "sesquiterpenoid catabolism" EXACT [] synonym: "sesquiterpenoid degradation" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016108 name: tetraterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetraterpenoid compounds, terpenoids with eight isoprene units." [ISBN:0198547684] synonym: "tetraterpene metabolic process" NARROW [] synonym: "tetraterpene metabolism" NARROW [] synonym: "tetraterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016109 name: tetraterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene biosynthesis" NARROW [] synonym: "tetraterpene biosynthetic process" NARROW [] synonym: "tetraterpenoid anabolism" EXACT [] synonym: "tetraterpenoid biosynthesis" EXACT [] synonym: "tetraterpenoid formation" EXACT [] synonym: "tetraterpenoid synthesis" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016110 name: tetraterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetraterpenoid compounds, terpenoids with eight isoprene units." [GOC:go_curators] synonym: "tetraterpene catabolic process" NARROW [] synonym: "tetraterpene catabolism" NARROW [] synonym: "tetraterpenoid breakdown" EXACT [] synonym: "tetraterpenoid catabolism" EXACT [] synonym: "tetraterpenoid degradation" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016111 name: polyterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyterpenoid compounds, terpenoids with more than eight isoprene units." [ISBN:0198547684] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] synonym: "polyterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0016112 name: polyterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] synonym: "polyterpenoid anabolism" EXACT [] synonym: "polyterpenoid biosynthesis" EXACT [] synonym: "polyterpenoid formation" EXACT [] synonym: "polyterpenoid synthesis" EXACT [] is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0016113 name: polyterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyterpenoid compounds, terpenoids with more than eight isoprene units." [GOC:go_curators] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] synonym: "polyterpenoid breakdown" EXACT [] synonym: "polyterpenoid catabolism" EXACT [] synonym: "polyterpenoid degradation" EXACT [] is_a: GO:0016111 ! polyterpenoid metabolic process is_a: GO:0016115 ! terpenoid catabolic process [Term] id: GO:0016114 name: terpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid anabolism" EXACT [] synonym: "terpenoid biosynthesis" EXACT [] synonym: "terpenoid formation" EXACT [] synonym: "terpenoid synthesis" EXACT [] xref: Wikipedia:Terpenoid is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0016115 name: terpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure." [GOC:ai] synonym: "terpenoid breakdown" EXACT [] synonym: "terpenoid catabolism" EXACT [] synonym: "terpenoid degradation" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0008300 ! isoprenoid catabolic process [Term] id: GO:0016116 name: carotenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [ISBN:0198547684] synonym: "carotenoid metabolism" EXACT [] is_a: GO:0016108 ! tetraterpenoid metabolic process [Term] id: GO:0016117 name: carotenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid anabolism" EXACT [] synonym: "carotenoid biosynthesis" EXACT [] synonym: "carotenoid formation" EXACT [] synonym: "carotenoid synthesis" EXACT [] xref: MetaCyc:CAROTENOID-PWY is_a: GO:0016109 ! tetraterpenoid biosynthetic process is_a: GO:0016116 ! carotenoid metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0016118 name: carotenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenoids, tetraterpenoid compounds in which two units of 4 isoprenoid residues joined head-to-tail are themselves joined tail-to-tail." [GOC:go_curators] synonym: "carotenoid breakdown" EXACT [] synonym: "carotenoid catabolism" EXACT [] synonym: "carotenoid degradation" EXACT [] is_a: GO:0016110 ! tetraterpenoid catabolic process is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016119 name: carotene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carotenes, hydrocarbon carotenoids." [ISBN:0198547684] synonym: "carotene metabolism" EXACT [] is_a: GO:0042214 ! terpene metabolic process [Term] id: GO:0016120 name: carotene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carotenes, hydrocarbon carotenoids." [GOC:go_curators] synonym: "carotene anabolism" EXACT [] synonym: "carotene biosynthesis" EXACT [] synonym: "carotene formation" EXACT [] synonym: "carotene synthesis" EXACT [] is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046246 ! terpene biosynthetic process [Term] id: GO:0016121 name: carotene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carotenes, hydrocarbon carotenoids." [GOC:go_curators] synonym: "carotene breakdown" EXACT [] synonym: "carotene catabolism" EXACT [] synonym: "carotene degradation" EXACT [] is_a: GO:0016119 ! carotene metabolic process is_a: GO:0046247 ! terpene catabolic process [Term] id: GO:0016122 name: xanthophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xanthophylls, oxygen-containing carotenoids." [ISBN:0198547684] synonym: "xanthophyll metabolism" EXACT [] is_a: GO:0016116 ! carotenoid metabolic process [Term] id: GO:0016123 name: xanthophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll anabolism" EXACT [] synonym: "xanthophyll biosynthesis" EXACT [] synonym: "xanthophyll formation" EXACT [] synonym: "xanthophyll synthesis" EXACT [] is_a: GO:0016117 ! carotenoid biosynthetic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016124 name: xanthophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthophylls, oxygen-containing carotenoids." [GOC:go_curators] synonym: "xanthophyll breakdown" EXACT [] synonym: "xanthophyll catabolism" EXACT [] synonym: "xanthophyll degradation" EXACT [] is_a: GO:0016118 ! carotenoid catabolic process is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0016125 name: sterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [ISBN:0198547684] synonym: "sterol metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0016126 name: sterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] synonym: "sterol anabolism" EXACT [] synonym: "sterol biosynthesis" EXACT [] synonym: "sterol formation" EXACT [] synonym: "sterol synthesis" EXACT [] xref: MetaCyc:PWY-2541 is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016125 ! sterol metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0016127 name: sterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:go_curators] synonym: "sterol breakdown" EXACT [] synonym: "sterol catabolism" EXACT [] synonym: "sterol degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016125 ! sterol metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0016128 name: phytosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosteroids, steroids of higher plants that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:mah, ISBN:0198547684] synonym: "phytosteroid metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0016129 name: phytosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah, ISBN:0471331309] synonym: "phytosteroid anabolism" EXACT [] synonym: "phytosteroid biosynthesis" EXACT [] synonym: "phytosteroid formation" EXACT [] synonym: "phytosteroid synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0016130 name: phytosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phytosteroids, steroids that differ from animal steroids in having substitutions at C24 and/or a double bond at C22. Phytosteroids are so named because they occur in higher plants; some, notably ergosterol, are also found in fungi." [GOC:go_curators, GOC:mah] synonym: "phytosteroid breakdown" EXACT [] synonym: "phytosteroid catabolism" EXACT [] synonym: "phytosteroid degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0016131 name: brassinosteroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid metabolism" EXACT [] is_a: GO:0016128 ! phytosteroid metabolic process is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0016132 name: brassinosteroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid anabolism" EXACT [] synonym: "brassinosteroid biosynthesis" EXACT [] synonym: "brassinosteroid formation" EXACT [] synonym: "brassinosteroid synthesis" EXACT [] xref: MetaCyc:PWY-2582 xref: MetaCyc:PWY-699 is_a: GO:0016129 ! phytosteroid biosynthetic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0016133 name: brassinosteroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of brassinosteroids, any of a group of steroid derivatives that occur at very low concentrations in plant tissues and may have hormone-like effects." [ISBN:0192801023] synonym: "brassinosteroid breakdown" EXACT [] synonym: "brassinosteroid catabolism" EXACT [] synonym: "brassinosteroid degradation" EXACT [] is_a: GO:0016130 ! phytosteroid catabolic process is_a: GO:0016131 ! brassinosteroid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0016134 name: saponin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [ISBN:0198547684] synonym: "saponin metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0016135 name: saponin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] synonym: "saponin anabolism" EXACT [] synonym: "saponin biosynthesis" EXACT [] synonym: "saponin formation" EXACT [] synonym: "saponin synthesis" EXACT [] is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016138 ! glycoside biosynthetic process [Term] id: GO:0016136 name: saponin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of saponins, glycosides of plants in which the aglycan (sapogenin) group is a terpene or steroid and the sugar group is a glucose, a galactose, a pentose, a methylpentose or an oligosaccharide. Saponins are powerful surfactant agents and membrane active; they are, hence, toxic to animals on injection." [GOC:go_curators] synonym: "saponin breakdown" EXACT [] synonym: "saponin catabolism" EXACT [] synonym: "saponin degradation" EXACT [] is_a: GO:0016134 ! saponin metabolic process is_a: GO:0016139 ! glycoside catabolic process [Term] id: GO:0016137 name: glycoside metabolic process namespace: biological_process alt_id: GO:0016140 def: "The chemical reactions and pathways involving glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [ISBN:0198547684] synonym: "glycoside metabolism" EXACT [] synonym: "O-glycoside metabolic process" EXACT [] synonym: "O-glycoside metabolism" EXACT [] is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0016138 name: glycoside biosynthetic process namespace: biological_process alt_id: GO:0016141 def: "The chemical reactions and pathways resulting in the formation of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] synonym: "glycoside anabolism" EXACT [] synonym: "glycoside biosynthesis" EXACT [] synonym: "glycoside formation" EXACT [] synonym: "glycoside synthesis" EXACT [] synonym: "O-glycoside anabolism" EXACT [] synonym: "O-glycoside biosynthesis" EXACT [] synonym: "O-glycoside biosynthetic process" EXACT [] synonym: "O-glycoside formation" EXACT [] synonym: "O-glycoside synthesis" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0016139 name: glycoside catabolic process namespace: biological_process alt_id: GO:0016142 def: "The chemical reactions and pathways resulting in the breakdown of glycosides, compounds in which a glycosyl group is substituted into a hydroxyl, thiol or selenol group in another compound." [GOC:go_curators] synonym: "glycoside breakdown" EXACT [] synonym: "glycoside catabolism" EXACT [] synonym: "glycoside degradation" EXACT [] synonym: "O-glycoside breakdown" EXACT [] synonym: "O-glycoside catabolic process" EXACT [] synonym: "O-glycoside catabolism" EXACT [] synonym: "O-glycoside degradation" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0016143 name: S-glycoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside metabolism" EXACT [] synonym: "thioglycoside metabolic process" EXACT [] synonym: "thioglycoside metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0016144 name: S-glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside anabolism" EXACT [] synonym: "S-glycoside biosynthesis" EXACT [] synonym: "S-glycoside formation" EXACT [] synonym: "S-glycoside synthesis" EXACT [] synonym: "thioglycoside biosynthesis" EXACT [] synonym: "thioglycoside biosynthetic process" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0016145 name: S-glycoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-glycosides, any compound in which a glycosyl group has been substituted into a thiol group." [ISBN:0198506732] synonym: "S-glycoside breakdown" EXACT [] synonym: "S-glycoside catabolism" EXACT [] synonym: "S-glycoside degradation" EXACT [] synonym: "thioglycoside catabolic process" EXACT [] synonym: "thioglycoside catabolism" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:1901658 ! glycosyl compound catabolic process [Term] id: GO:0016146 name: obsolete protein-synthesizing GTPase activity, initiation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, initiation" EXACT [] is_obsolete: true consider: GO:0003743 consider: GO:0003924 consider: GO:0006412 consider: GO:0006413 [Term] id: GO:0016147 name: obsolete protein-synthesizing GTPase activity, elongation namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, elongation" EXACT [] is_obsolete: true consider: GO:0003746 consider: GO:0003924 consider: GO:0006412 consider: GO:0006414 [Term] id: GO:0016148 name: obsolete protein-synthesizing GTPase activity, termination namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.48] comment: This term was made obsolete because it contains both process and function information. synonym: "protein-synthesizing GTPase activity, termination" EXACT [] is_obsolete: true consider: GO:0003924 consider: GO:0006412 consider: GO:0006415 consider: GO:0008079 [Term] id: GO:0016149 name: translation release factor activity, codon specific namespace: molecular_function def: "A translation release factor that is specific for one or more particular termination codons; acts at the ribosomal A-site and require polypeptidyl-tRNA at the P-site." [ISBN:0198547684] is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016150 name: translation release factor activity, codon nonspecific namespace: molecular_function def: "A translation release factor that is not specific to particular codons; binds to guanine nucleotides." [ISBN:0198547684] is_a: GO:0003747 ! translation release factor activity [Term] id: GO:0016151 name: nickel cation binding namespace: molecular_function def: "Interacting selectively and non-covalently with nickel (Ni) cations." [GOC:ai] synonym: "nickel binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0016152 name: mercury (II) reductase activity namespace: molecular_function alt_id: GO:0018692 def: "Catalysis of the reaction: H(+) + Hg + NADP(+) = Hg(2+) + NADPH." [EC:1.16.1.1, RHEA:23856] synonym: "Hg:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.1] synonym: "mer A" RELATED [EC:1.16.1.1] synonym: "mercurate(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric ion reductase activity" EXACT [EC:1.16.1.1] synonym: "mercuric reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury reductase activity" EXACT [EC:1.16.1.1] synonym: "mercury(II) reductase activity" EXACT [EC:1.16.1.1] synonym: "reduced NADP:mercuric ion oxidoreductase activity" EXACT [EC:1.16.1.1] xref: EC:1.16.1.1 xref: KEGG:R02807 xref: MetaCyc:MERCURY-II-REDUCTASE-RXN xref: RHEA:23856 xref: UM-BBD_reactionID:r0406 is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0016153 name: urocanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 4-imidazolone-5-propanoate + H(+) = trans-urocanate + H(2)O." [EC:4.2.1.49, RHEA:13101] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase (urocanate-forming)" EXACT [EC:4.2.1.49] synonym: "3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate hydro-lyase activity" EXACT [EC:4.2.1.49] synonym: "imidazolonepropionate hydrolase activity" EXACT [EC:4.2.1.49] synonym: "urocanase activity" EXACT [EC:4.2.1.49] xref: EC:4.2.1.49 xref: KEGG:R02914 xref: MetaCyc:UROCANATE-HYDRATASE-RXN xref: reactome:R-HSA-70903 "urocanate + H2O => 4-imidazolone-5-propionate" xref: RHEA:13101 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016154 name: pyrimidine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine nucleoside + phosphate = pyrimidine + alpha-D-ribose 1-phosphate." [EC:2.4.2.2] synonym: "Py-NPase activity" EXACT [EC:2.4.2.2] synonym: "pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.2] xref: EC:2.4.2.2 xref: MetaCyc:PYRIMIDINE-NUCLEOSIDE-PHOSPHORYLASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0016155 name: formyltetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H(2)O + NADP(+) = (6S)-5,6,7,8-tetrahydrofolate + CO(2) + H(+) + NADPH." [EC:1.5.1.6, RHEA:10180] synonym: "10-formyl tetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H2PtGlu:NADP oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "10-formyl-H4folate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] synonym: "10-formyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.6] synonym: "N10-formyltetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.6] xref: EC:1.5.1.6 xref: KEGG:R00941 xref: MetaCyc:FORMYLTETRAHYDROFOLATE-DEHYDROGENASE-RXN xref: RHEA:10180 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0016156 name: fumarate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + succinate = fumarate + H(+) + NADH." [EC:1.3.1.6, RHEA:18281] synonym: "NADH-dependent fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "NADH-fumarate reductase activity" EXACT [EC:1.3.1.6] synonym: "succinate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.6] xref: EC:1.3.1.6 xref: KEGG:R00402 xref: MetaCyc:FUMARATE-REDUCTASE-NADH-RXN xref: RHEA:18281 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016157 name: sucrose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-fructose = UDP + sucrose." [EC:2.4.1.13] synonym: "NDP-glucose:D-fructose 2-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose synthetase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-UDP glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "sucrose-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDP-glucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "UDPglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] synonym: "uridine diphosphoglucose-fructose glucosyltransferase activity" EXACT [EC:2.4.1.13] xref: EC:2.4.1.13 xref: MetaCyc:SUCROSE-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016158 name: 3-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = D-myo-inositol 1,2,4,5,6-pentakisphosphate + phosphate." [EC:3.1.3.8] synonym: "1-phytase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexakisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.8] synonym: "myo-inositol-hexaphosphate 3-phosphohydrolase activity" EXACT [] synonym: "phytase activity" BROAD [] synonym: "phytate 1-phosphatase activity" EXACT [EC:3.1.3.8] synonym: "phytate 3-phosphatase activity" EXACT [] xref: EC:3.1.3.8 xref: MetaCyc:RXN0-1001 xref: RHEA:16989 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0016159 name: muconolactone delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = 3,4-dihydro-5-oxofuran-2-acetate." [EC:5.3.3.4] synonym: "5-oxo-4,5-dihydrofuran-2-acetate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.4] synonym: "muconolactone D-isomerase activity" EXACT [] synonym: "muconolactone isomerase activity" EXACT [EC:5.3.3.4] xref: EC:5.3.3.4 xref: MetaCyc:MUCONOLACTONE-DELTA-ISOMERASE-RXN xref: RHEA:12348 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0016160 name: amylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of amylose or an amylose derivative." [GOC:ai] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016161 name: beta-amylase activity namespace: molecular_function def: "Catalysis of the reaction: (1,4-alpha-D-glucosyl)(n+1) + H2O = (1,4-alpha-D-glucosyl)(n-1) + alpha-maltose. This reaction is the hydrolysis of 1,4-alpha-glucosidic linkages in polysaccharides so as to remove successive maltose units from the non-reducing ends of the chains." [EC:3.2.1.2] synonym: "1,4-alpha-D-glucan maltohydrolase activity" EXACT [EC:3.2.1.2] synonym: "beta amylase activity" EXACT [EC:3.2.1.2] synonym: "glycogenase activity" BROAD [EC:3.2.1.2] synonym: "saccharogen amylase activity" EXACT [EC:3.2.1.2] xref: EC:3.2.1.2 xref: MetaCyc:RXN-12279 xref: MetaCyc:RXN-1827 is_a: GO:0016160 ! amylase activity [Term] id: GO:0016162 name: cellulose 1,4-beta-cellobiosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4)-beta-D-glucosidic linkages in cellulose and cellotetraose, releasing cellobiose from the non-reducing ends of the chains." [EC:3.2.1.91] synonym: "1,4-beta-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-D-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "1,4-beta-glucan cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "avicelase activity" BROAD [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "beta-1,4-glucan cellobiosylhydrolase activity" EXACT [EC:3.2.1.91] synonym: "C1 cellulase activity" EXACT [EC:3.2.1.91] synonym: "CBH 1" RELATED [EC:3.2.1.91] synonym: "cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "cellobiohydrolase I" RELATED [EC:3.2.1.91] synonym: "cellobiosidase activity" EXACT [EC:3.2.1.91] synonym: "exo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.91] synonym: "exo-beta-1,4-glucan cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exo-cellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exocellobiohydrolase activity" EXACT [EC:3.2.1.91] synonym: "exoglucanase activity" EXACT [EC:3.2.1.91] xref: EC:3.2.1.91 xref: MetaCyc:3.2.1.91-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016163 name: nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] synonym: "iron-iron nitrogenase activity" NARROW [] synonym: "molybdenum-iron nitrogenase activity" NARROW [] synonym: "reduced ferredoxin:dinitrogen oxidoreductase (ATP-hydrolysing) activity" EXACT [EC:1.18.6.1] synonym: "vanadium-iron nitrogenase activity" NARROW [] xref: EC:1.18.6.1 xref: MetaCyc:NITROGENASE-RXN xref: UM-BBD_enzymeID:e0395 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0016164 name: obsolete Mo-molybdopterin oxidoreductase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the differentia from the parent is a gene product feature (specifically, the presence of a molybdopterin cofactor in the protein). It has also never been defined. synonym: "Mo-molybdopterin oxidoreductase activity" EXACT [] synonym: "molybdopterin oxidoreductase activity" EXACT [] is_obsolete: true replaced_by: GO:0016491 [Term] id: GO:0016165 name: linoleate 13S-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: linoleate + O2 = (9Z,11E)-(13S)-13-hydroperoxyoctadeca-9,11-dienoate." [EC:1.13.11.12, GOC:lb] synonym: "carotene oxidase activity" NARROW [EC:1.13.11.12] synonym: "fat oxidase activity" EXACT [EC:1.13.11.12] synonym: "linoleate:oxygen 13-oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lionoleate:O2 oxidoreductase activity" EXACT [EC:1.13.11.12] synonym: "lipoperoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxidase activity" EXACT [EC:1.13.11.12] synonym: "lipoxydase activity" EXACT [EC:1.13.11.12] synonym: "lipoxygenase activity" BROAD [] xref: EC:1.13.11.12 xref: MetaCyc:LIPOXYGENASE-RXN xref: RHEA:22780 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0016166 name: phytoene dehydrogenase activity namespace: molecular_function def: "Catalysis of the dehydrogenation of phytoene to produce a carotenoid intermediate such as phytofluene." [http://www.chem.qmul.ac.uk/iubmb/enzyme/reaction/terp/carot.html] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016167 name: glial cell-derived neurotrophic factor receptor activity namespace: molecular_function def: "Combining with glial cell line-derived neurotrophic factor and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling] synonym: "GDNF receptor activity" EXACT [GOC:mah] synonym: "glial cell line-derived neurotrophic factor receptor activity" EXACT [GOC:bf] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0016168 name: chlorophyll binding namespace: molecular_function def: "Interacting selectively and non-covalently with chlorophyll; any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment." [GOC:jl] is_a: GO:0043168 ! anion binding is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0016169 name: bacteriochlorophyll c binding namespace: molecular_function def: "Interacting selectively and non-covalently with bacteriochlorophyll c, a chlorophyll of photosynthetic bacteria, for example green sulfur bacteria." [ISBN:0192800981] is_a: GO:0042314 ! bacteriochlorophyll binding [Term] id: GO:0016170 name: interleukin-15 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-15 receptor." [GOC:ai] synonym: "IL-15" NARROW [] synonym: "interleukin-15 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0016171 name: obsolete cell surface antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "cell surface antigen" EXACT [] is_obsolete: true [Term] id: GO:0016172 name: obsolete antifreeze activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals in organismal fluid (e.g. blood) at below freezing exogenous temperatures." [GOC:jl] comment: This term was made obsolete because it refers to a biological process. synonym: "antifreeze activity" EXACT [] is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016173 name: obsolete ice nucleation inhibitor activity namespace: molecular_function def: "OBSOLETE. Inhibits the formation of ice crystals." [GOC:ai] comment: This term was made obsolete because it refers to a biological process. synonym: "ice nucleation inhibitor activity" EXACT [] is_obsolete: true consider: GO:0042309 consider: GO:0050825 consider: GO:0050826 [Term] id: GO:0016174 name: NAD(P)H oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + O2 = NAD(P)+ + hydrogen peroxide." [EC:1.6.3.1] synonym: "dual oxidase activity" RELATED [EC:1.6.3.1] synonym: "NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.6.3.1] synonym: "NADPH oxidase" BROAD [EC:1.6.3.1] synonym: "p138tox" RELATED [EC:1.6.3.1] synonym: "ThOX activity" NARROW [EC:1.6.3.1] synonym: "THOX2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid NADPH oxidase activity" NARROW [] synonym: "thyroid oxidase 2 activity" NARROW [EC:1.6.3.1] synonym: "thyroid oxidase activity" NARROW [EC:1.6.3.1] xref: EC:1.6.3.1 xref: reactome:R-HSA-5693681 "DUOX1,2 reduce O2 to H2O2" is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [Term] id: GO:0016175 name: superoxide-generating NADPH oxidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + O2 = NAD(P)H + O2-." [GOC:ai, PMID:10806195] synonym: "cytochrome B-245" RELATED [] xref: EC:1.6.3 xref: reactome:R-HSA-1222376 "NOX2 generates superoxide from oxygen" xref: reactome:R-HSA-1236967 "Alkalization of the phagosomal lumen by NOX2" xref: reactome:R-HSA-1497810 "Uncoupled eNOS favours the formation of superoxide" xref: reactome:R-HSA-5218841 "NADPH oxidase 2 generates superoxide from oxygen" xref: reactome:R-HSA-5668629 "Production of phagocyte oxygen radicals by NOX2 complex bound to RAC2:GTP" xref: reactome:R-HSA-5668718 "NOX1 complex:RAC1:GTP generates superoxide from oxygen" xref: reactome:R-HSA-5668731 "NOX3 complex:RAC1:GTP generates superoxide from oxygen" xref: reactome:R-HSA-6789092 "NOX2 generates superoxide anion from oxygen" xref: reactome:R-HSA-6807557 "NOX4, NOX5 reduce O2 to O2.-" is_a: GO:0050664 ! oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [Term] id: GO:0016176 name: superoxide-generating NADPH oxidase activator activity namespace: molecular_function def: "Increases the activity of the enzyme superoxide-generating NADPH oxidase." [GOC:ai] synonym: "neutrophil cytosol factor 2" NARROW [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0016180 name: snRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary small nuclear RNA (snRNA) transcript into a mature snRNA molecule." [GOC:jl] is_a: GO:0016073 ! snRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0016182 name: synaptic vesicle budding from endosome namespace: biological_process def: "Budding of synaptic vesicles during the formation of constitutive recycling vesicles from early endosomes." [GOC:curators, PMID:10099709, PMID:24596248] subset: goslim_synapse synonym: "endosome to synaptic vesicle budding" RELATED [GOC:mah] synonym: "synaptic vesicle budding involved in synaptic vesicle exocytosis" EXACT [GOC:mah] is_a: GO:0046907 ! intracellular transport is_a: GO:0070142 ! synaptic vesicle budding is_a: GO:0099003 ! vesicle-mediated transport in synapse relationship: part_of GO:0036466 ! synaptic vesicle recycling via endosome [Term] id: GO:0016183 name: synaptic vesicle coating namespace: biological_process def: "The formation of clathrin coated pits in the presynaptic membrane endocytic zone, triggered by the presence of high concentrations of synaptic vesicle components. This process leads to, but does not include budding of the membrane to form new vesicles." [GOC:curators, PMID:10099709, PMID:20448150] subset: goslim_synapse is_a: GO:0006901 ! vesicle coating relationship: part_of GO:0016185 ! synaptic vesicle budding from presynaptic endocytic zone membrane [Term] id: GO:0016184 name: obsolete synaptic vesicle retrieval namespace: biological_process def: "OBSOLETE. Return of a vesicle from the postsynaptic membrane to presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle retrieval" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016185 name: synaptic vesicle budding from presynaptic endocytic zone membrane namespace: biological_process def: "Evagination of the presynaptic membrane, resulting in the formation of a new synaptic vesicle." [GOC:curators, PMID:10099709, PMID:20448150] subset: goslim_synapse synonym: "synaptic vesicle budding from pre-synaptic membrane" EXACT [] synonym: "synaptic vesicle budding involved in synaptic vesicle endocytosis" EXACT [GOC:mah] is_a: GO:0070142 ! synaptic vesicle budding relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016186 name: obsolete synaptic vesicle fission namespace: biological_process def: "OBSOLETE. Separation of a synaptic vesicle from the presynaptic membrane." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle fission" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016187 name: obsolete synaptic vesicle internalization namespace: biological_process def: "OBSOLETE. Internalization of the contents of a synaptic vesicle into the postsynaptic membrane following endocytosis." [GOC:curators] comment: This term was made obsolete because it was wrongly defined. synonym: "synaptic vesicle internalization" EXACT [] is_obsolete: true consider: GO:0016192 [Term] id: GO:0016188 name: synaptic vesicle maturation namespace: biological_process def: "Steps required to form an initiated synaptic vesicle into a fully formed and transmissible synaptic vesicle." [GOC:curators, PMID:10099709] is_a: GO:0016050 ! vesicle organization is_a: GO:0021700 ! developmental maturation [Term] id: GO:0016189 name: synaptic vesicle to endosome fusion namespace: biological_process def: "Fusion of a synaptic vesicle with an endosome." [GOC:curators, PMID:10099709] comment: This covers fusion of synaptic vesicles trafficked to the synapse as well as fusion of endocytosed vesicles as part of recycling. It is there for not part of the synaptic vesicle cycle. subset: goslim_synapse is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0099532 ! synaptic vesicle endosomal processing [Term] id: GO:0016191 name: synaptic vesicle uncoating namespace: biological_process def: "The removal of the protein coat on a synaptic vesicle following the pinching step at the end of budding from the presynaptic membrane." [GOC:curators, PMID:10099709, PMID:24596248] subset: goslim_synapse synonym: "synaptic vesicle coat depolymerization" EXACT [] synonym: "synaptic vesicle coat protein depolymerization" EXACT [] is_a: GO:0072318 ! clathrin coat disassembly relationship: part_of GO:0048488 ! synaptic vesicle endocytosis [Term] id: GO:0016192 name: vesicle-mediated transport namespace: biological_process alt_id: GO:0006899 def: "A cellular transport process in which transported substances are moved in membrane-bounded vesicles; transported substances are enclosed in the vesicle lumen or located in the vesicle membrane. The process begins with a step that directs a substance to the forming vesicle, and includes vesicle budding and coating. Vesicles are then targeted to, and fuse with, an acceptor membrane." [GOC:ai, GOC:mah, ISBN:08789310662000] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_pombe synonym: "nonselective vesicle transport" NARROW [] synonym: "protein sorting along secretory pathway" RELATED [] synonym: "vesicle trafficking" RELATED [] synonym: "vesicle transport" EXACT [] synonym: "vesicular transport" EXACT [GOC:mah] is_a: GO:0006810 ! transport [Term] id: GO:0016197 name: endosomal transport namespace: biological_process alt_id: GO:0032439 def: "The directed movement of substances mediated by an endosome, a membrane-bounded organelle that carries materials enclosed in the lumen or located in the endosomal membrane." [ISBN:0198506732] subset: goslim_yeast synonym: "endosome localisation" EXACT [GOC:mah] synonym: "endosome localization" RELATED [] synonym: "endosome transport" RELATED [GOC:bf] is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0016198 name: axon choice point recognition namespace: biological_process def: "The recognition of molecules at a choice point by an axon growth cone; at a choice point the growth cone determines the direction of its future growth." [PMID:10218152] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0016199 name: axon midline choice point recognition namespace: biological_process def: "The recognition of molecules at the central nervous system midline choice point by an axon growth cone; this choice point determines whether the growth cone will cross the midline." [PMID:11376484] is_a: GO:0016198 ! axon choice point recognition [Term] id: GO:0016200 name: synaptic target attraction namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemoattractant signals from, and grows towards, potential targets." [GOC:mah, ISBN:0878932437] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016201 name: synaptic target inhibition namespace: biological_process def: "The process in which a neuronal cell in a multicellular organism recognizes chemorepellent signals that inhibit its growth toward the source." [GOC:mah, ISBN:0878932437] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0008039 ! synaptic target recognition [Term] id: GO:0016202 name: regulation of striated muscle tissue development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle development." [GOC:go_curators] is_a: GO:0048634 ! regulation of muscle organ development is_a: GO:1901861 ! regulation of muscle tissue development relationship: regulates GO:0014706 ! striated muscle tissue development [Term] id: GO:0016203 name: muscle attachment namespace: biological_process def: "The developmental process in which a skeletal muscle attaches to its target (such as bone or body wall)." [GOC:isa_complete, GOC:sart] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0016204 name: determination of muscle attachment site namespace: biological_process def: "The process that mediates the transfer of information from the cells of a muscle to those of its intended target, thereby identifying the target site." [GOC:isa_complete] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0016203 ! muscle attachment [Term] id: GO:0016205 name: selenocysteine methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: selenocysteine + S-adenosyl-L-methionine = Se-methylselenocysteine + S-adenosyl-homocysteine." [EC:2.1.1.280, PMID:10026151] xref: EC:2.1.1.280 xref: MetaCyc:RXN-11061 xref: RHEA:26341 is_a: GO:0051995 ! Se-methyltransferase activity [Term] id: GO:0016206 name: catechol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a catechol = S-adenosyl-L-homocysteine + a guaiacol." [EC:2.1.1.6] synonym: "catechol methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "catecholamine O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "COMT I" RELATED [EC:2.1.1.6] synonym: "COMT II" RELATED [EC:2.1.1.6] synonym: "MB-COMT (membrane-bound form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] synonym: "S-adenosyl-L-methionine:catechol O-methyltransferase activity" EXACT [EC:2.1.1.6] synonym: "S-COMT (soluble form of catechol-O-methyltransferase)" RELATED [EC:2.1.1.6] xref: EC:2.1.1.6 xref: MetaCyc:CATECHOL-O-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-175983 "COMT transfer CH3 from AdoMet to 3,4DHBNZ" xref: reactome:R-HSA-8955010 "LRTOMT transfers methyl group from AdoMet to DA, forming 3MT" is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016207 name: 4-coumarate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-coumarate + CoA = AMP + diphosphate + 4-coumaroyl-CoA." [EC:6.2.1.12] synonym: "4-coumarate-CoA synthetase activity" EXACT [] synonym: "4-coumarate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.12] synonym: "4-coumarate:CoA ligase activity" EXACT [] synonym: "4-coumarate:coenzyme A ligase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaroyl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "4CL" RELATED [EC:6.2.1.12] synonym: "caffeolyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "feruloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamate:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "hydroxycinnamoyl CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaroyl CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-coumaryl-CoA synthetase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamic acid:CoA ligase activity" EXACT [EC:6.2.1.12] synonym: "p-hydroxycinnamoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] synonym: "sinapoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.12] xref: EC:6.2.1.12 xref: KEGG:R01616 xref: MetaCyc:4-COUMARATE--COA-LIGASE-RXN xref: RHEA:19641 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0016208 name: AMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with AMP, adenosine monophosphate." [GOC:go_curators] is_a: GO:0008144 ! drug binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding [Term] id: GO:0016209 name: antioxidant activity namespace: molecular_function def: "Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage." [ISBN:0198506732] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0003674 ! molecular_function [Term] id: GO:0016210 name: naringenin-chalcone synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 malonyl-CoA + 4-coumaroyl-CoA = 4 CoA + naringenin chalcone + 3 CO2." [EC:2.3.1.74] synonym: "DOCS" NARROW [] synonym: "malonyl-CoA:4-coumaroyl-CoA malonyltransferase (cyclizing)" BROAD [EC:2.3.1.74] xref: EC:2.3.1.74 xref: MetaCyc:NARINGENIN-CHALCONE-SYNTHASE-RXN xref: RHEA:11128 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016211 name: ammonia ligase activity namespace: molecular_function def: "Catalysis of the ligation of ammonia (NH3) to another substance via a carbon-nitrogen bond with concomitant breakage of a diphosphate linkage, usually in a nucleoside triphosphate." [GOC:jl] xref: EC:6.3.1 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0016212 name: kynurenine-oxoglutarate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-glutamate." [EC:2.6.1.7] synonym: "kynurenine 2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine aminotransferase activity" BROAD [EC:2.6.1.7] synonym: "kynurenine transaminase (cyclizing)" EXACT [EC:2.6.1.7] synonym: "kynurenine--oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "kynurenine-oxoglutarate aminotransferase activity" EXACT [] synonym: "L-kynurenine aminotransferase activity" EXACT [EC:2.6.1.7] synonym: "L-kynurenine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.7] xref: EC:2.6.1.7 xref: MetaCyc:2.6.1.7-RXN xref: reactome:R-HSA-893583 "kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate" xref: reactome:R-HSA-893596 "PXLP-KYAT1 dimer transaminates L-KYN to AP-DOBu" xref: reactome:R-HSA-901097 "kynurenine + pyruvate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + alanine [CCBL2]" xref: RHEA:20964 is_a: GO:0036137 ! kynurenine aminotransferase activity [Term] id: GO:0016213 name: linoleoyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: linoleoyl-CoA + reduced acceptor + O2 = gamma-linolenoyl-CoA + acceptor + 2 H2O." [EC:1.14.19.3] comment: Note that this function was formerly EC:1.14.99.25. synonym: "delta(6)-acyl CoA desaturase activity" BROAD [] synonym: "delta(6)-desaturase activity" BROAD [] synonym: "delta(6)-fatty acyl-CoA desaturase activity" BROAD [] synonym: "delta6-acyl CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "delta6-fatty acyl-CoA desaturase activity" EXACT [EC:1.14.19.3] synonym: "fatty acid 6-desaturase activity" BROAD [] synonym: "fatty acid delta(6)-desaturase activity" BROAD [] synonym: "fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] synonym: "linoleate desaturase activity" RELATED [] synonym: "linoleic acid desaturase activity" RELATED [] synonym: "linoleic desaturase activity" RELATED [] synonym: "linoleoyl CoA desaturase activity" EXACT [] synonym: "linoleoyl-CoA,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.3] synonym: "linoleoyl-coenzyme A desaturase activity" EXACT [] synonym: "long-chain fatty acid delta(6)-desaturase activity" BROAD [] synonym: "long-chain fatty acid delta6-desaturase activity" EXACT [EC:1.14.19.3] xref: EC:1.14.19.3 xref: MetaCyc:1.14.19.3-RXN xref: reactome:R-HSA-2046084 "Desaturation of alpha-linoleoyl-CoA to Stearidonoyl-CoA" xref: reactome:R-HSA-2046096 "Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA" xref: reactome:R-HSA-2046097 "Desaturation of tetracosatetraenoyl-CoA to tetracosapentaenoyl-CoA" xref: reactome:R-HSA-2046099 "Desaturation of tetracosapentaenoyl-CoA to tetracosahexaenoyl-CoA" xref: RHEA:22196 is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0016215 name: acyl-CoA desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = desaturated-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.1, EC:1.14.19.5, GOC:mah] synonym: "CoA desaturase activity" BROAD [] xref: EC:1.14.19 is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0016216 name: isopenicillin-N synthase activity namespace: molecular_function def: "Catalysis of the reaction: N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine + O(2) = 2 H(2)O + isopenicillin N." [EC:1.21.3.1, RHEA:22428] synonym: "isopenicillin N synthase activity" EXACT [EC:1.21.3.1] synonym: "isopenicillin-N synthetase activity" EXACT [] synonym: "N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine:oxygen oxidoreductase (cyclizing)" EXACT [EC:1.21.3.1] xref: EC:1.21.3.1 xref: KEGG:R04872 xref: MetaCyc:1.21.3.1-RXN xref: RHEA:22428 is_a: GO:0046993 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with oxygen as acceptor [Term] id: GO:0016217 name: N-ethylammeline chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deethylsimazine + H2O = N-ethylammeline + chloride + H+." [MetaCyc:R465-RXN] xref: MetaCyc:R465-RXN is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0016218 name: obsolete polyketide synthase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because the activity it describes does not exist, and the gene product with the name 'polyketide synthase' has multiple functional domains, so using the name to describe a single function would be misleading. synonym: "polyketide synthase activity" EXACT [] is_obsolete: true replaced_by: GO:0030639 consider: GO:0034081 [Term] id: GO:0016222 name: procollagen-proline 4-dioxygenase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of procollagen trans-4-hydroxy-L-proline and succinate from procollagen L-proline and 2-oxoglutarate, requiring Fe2+ and ascorbate. Contains two alpha subunits that contribute to most parts of the catalytic sites, and two beta subunits that are identical to protein-disulfide isomerase." [PMID:14500733, PMID:7753822] synonym: "procollagen-proline, 2-oxoglutarate-4-dioxygenase complex" EXACT [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase complex" BROAD [EC:1.14.11.2] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0016223 name: beta-alanine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxopropanoate = pyruvate + beta-alanine." [EC:2.6.1.18] synonym: "beta-alanine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-alpha-alanine transaminase activity" EXACT [EC:2.6.1.18] synonym: "beta-alanine-pyruvate aminotransferase activity" EXACT [] synonym: "L-alanine:3-oxopropanoate aminotransferase activity" EXACT [EC:2.6.1.18] synonym: "omega-amino acid--pyruvate aminotransferase activity" EXACT [EC:2.6.1.18] xref: EC:2.6.1.18 xref: MetaCyc:2.6.1.18-RXN xref: reactome:R-HSA-909776 "beta-alanine + pyruvate => 3-oxopropanoate + alanine" xref: RHEA:14077 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0016226 name: iron-sulfur cluster assembly namespace: biological_process def: "The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] subset: goslim_metagenomics synonym: "iron-sulfur cluster biosynthesis" RELATED [] synonym: "iron-sulphur cluster assembly" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0016227 name: obsolete tRNA sulfurtransferase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + 'activated' tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4] comment: This term was made obsolete because tRNA thionucleotide formation is a multistep process; there is no single reaction in which cysteine reacts with an activated tRNA directly synonym: "L-cysteine:tRNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer ribonucleate sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA sulfurtransferase activity" EXACT [EC:2.8.1.4] synonym: "transfer RNA thiolase activity" EXACT [EC:2.8.1.4] synonym: "tRNA sulfurtransferase activity" EXACT [] synonym: "tRNA sulphurtransferase activity" EXACT [] xref: EC:2.8.1.4 xref: MetaCyc:TRNA-S-TRANSFERASE-RXN is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0016229 name: steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which one substrate is a sterol derivative." [GOC:mah] xref: EC:1.1.1 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016230 name: sphingomyelin phosphodiesterase activator activity namespace: molecular_function def: "Increases the activity of the enzyme sphingomyelin phosphodiesterase." [GOC:ai] synonym: "neutral sphingomyelinase activator" EXACT [] is_a: GO:0016004 ! phospholipase activator activity [Term] id: GO:0016231 name: beta-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-beta-D-glucosaminides." [EC:3.2.1.52, MetaCyc:3.2.1.52-RXN] is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0016232 name: HNK-1 sulfotransferase activity namespace: molecular_function def: "Catalysis of the synthesis of the HKK-1 carbohydrate epitope; adds a sulfate group to a precursor, GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R), forming sulfo-3GlcA-beta-(1->3)-Gal-beta-(1->4)-GlcNAc-beta-(1->R)." [PMID:9478973] synonym: "HNK-1 sulphotransferase activity" EXACT [] xref: reactome:R-HSA-6786048 "CHST10 transfers SO4(2-) from PAPS to GlcA-LacN on NCAM1" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0016233 name: telomere capping namespace: biological_process def: "A process in which telomeres are protected from degradation and fusion, thereby ensuring chromosome stability by protecting the ends from both degradation and from being recognized as damaged DNA. May be mediated by specific single- or double-stranded telomeric DNA binding proteins." [GOC:mah, GOC:rn, PMID:11349150, PMID:11352055] synonym: "telomere end protection" EXACT [] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0016234 name: inclusion body namespace: cellular_component def: "A discrete intracellular part formed of aggregated molecules such as proteins or other biopolymers." [GOC:mah, PMID:11121744] synonym: "cellular inclusion" RELATED [NIF_Subcellular:sao120573470] synonym: "neuronal cytoplasmic inclusion" NARROW [] xref: NIF_Subcellular:sao120573470 xref: Wikipedia:Inclusion_bodies is_a: GO:0044424 ! intracellular part [Term] id: GO:0016235 name: aggresome namespace: cellular_component def: "An inclusion body formed by dynein-dependent retrograde transport of an aggregated protein on microtubules." [PMID:11121744] xref: Wikipedia:Aggresome is_a: GO:0016234 ! inclusion body [Term] id: GO:0016236 name: macroautophagy namespace: biological_process alt_id: GO:0034262 def: "The major inducible pathway for the general turnover of cytoplasmic constituents in eukaryotic cells, it is also responsible for the degradation of active cytoplasmic enzymes and organelles during nutrient starvation. Macroautophagy involves the formation of double-membrane-bounded autophagosomes which enclose the cytoplasmic constituent targeted for degradation in a membrane-bounded structure. Autophagosomes then fuse with a lysosome (or vacuole) releasing single-membrane-bounded autophagic bodies that are then degraded within the lysosome (or vacuole). Some types of macroautophagy, e.g. pexophagy, mitophagy, involve selective targeting of the targets to be degraded." [PMID:11099404, PMID:12914914, PMID:15798367, PMID:16973210, PMID:20159618, PMID:9412464] comment: Targeted macroautophagy sometimes targets regions of cytoplasm containing non-self, such as virus particles or components (e.g. see PMID:20159618). As this is essentially the same process as macroautophagy that encloses and digests only self, the term autophagy is still used despite the enclosure of some non-self (non-auto) entities. synonym: "autophagy" BROAD [] is_a: GO:0006914 ! autophagy [Term] id: GO:0016237 name: lysosomal microautophagy namespace: biological_process def: "The transfer of cytosolic components into the lysosomal compartment by direct invagination of the lysosomal membrane without prior sequestration into an autophagosome. The engulfing membranes fuse, resulting in the lysosomal delivery of the cargo wrapped in a single membrane derived from the invaginated lysosomal membrane. In S. cerevisiae, the vacuole is the lysosomal compartment." [PMID:14679207, PMID:15798367, PMID:16973210, PMID:9566964] is_a: GO:0006914 ! autophagy [Term] id: GO:0016239 name: positive regulation of macroautophagy namespace: biological_process def: "Any process, such as recognition of nutrient depletion, that activates or increases the rate of macroautophagy to bring cytosolic macromolecules to the vacuole/lysosome for degradation." [GOC:go_curators, PMID:9412464] synonym: "activation of macroautophagy" NARROW [] synonym: "positive regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "stimulation of macroautophagy" NARROW [] synonym: "up regulation of macroautophagy" EXACT [] synonym: "up-regulation of macroautophagy" EXACT [] synonym: "upregulation of macroautophagy" EXACT [] is_a: GO:0010508 ! positive regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy relationship: positively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016240 name: autophagosome membrane docking namespace: biological_process def: "The initial attachment of an autophagosome membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane. Docking requires only that the two membranes come close enough for these proteins to interact and adhere." [GOC:autophagy, GOC:mah] synonym: "autophagic vacuole docking" EXACT [GOC:autophagy] is_a: GO:0140056 ! organelle localization by membrane tethering relationship: part_of GO:0097352 ! autophagosome maturation [Term] id: GO:0016241 name: regulation of macroautophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of macroautophagy." [GOC:krc] synonym: "regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy relationship: regulates GO:0016236 ! macroautophagy [Term] id: GO:0016242 name: negative regulation of macroautophagy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of macroautophagy." [GOC:go_curators] synonym: "down regulation of macroautophagy" EXACT [] synonym: "down-regulation of macroautophagy" EXACT [] synonym: "downregulation of macroautophagy" EXACT [] synonym: "inhibition of macroautophagy" NARROW [] synonym: "negative regulation of starvation-induced autophagy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010507 ! negative regulation of autophagy is_a: GO:0016241 ! regulation of macroautophagy relationship: negatively_regulates GO:0016236 ! macroautophagy [Term] id: GO:0016243 name: regulation of autophagosome size namespace: biological_process def: "Any process that modulates the size of the autophagosome." [GOC:autophagy, GOC:krc] synonym: "regulation of autophagic vacuole size" EXACT [GOC:autophagy] is_a: GO:0032535 ! regulation of cellular component size is_a: GO:1905037 ! autophagosome organization [Term] id: GO:0016246 name: RNA interference namespace: biological_process def: "The process in which double-stranded RNAs silence cognate genes. Involves posttranscriptional gene inactivation ('silencing') both of transgenes or dsRNA introduced into a germline, and of the host gene(s) homologous to the transgenes or dsRNA. This silencing is triggered by the introduction of transgenes or double-stranded RNA (dsRNA), and can occur through a specific decrease in the level of mRNA, or by negative regulation of translation, of both host genes and transgenes." [GOC:ems, PMID:11201747, PMID:11713190, PMID:18771919] comment: Note that this term refers specifically to posttranscriptional mechanisms by which small interfering RNAs down-regulate gene expression. Also consider annotating to other descendants of 'gene silencing by RNA ; GO:0031047'. synonym: "posttranscriptional gene silencing by siRNA" EXACT [GOC:mah] synonym: "RNAi" EXACT [] xref: Wikipedia:RNA_interference is_a: GO:0035194 ! posttranscriptional gene silencing by RNA [Term] id: GO:0016247 name: channel regulator activity namespace: molecular_function def: "Modulates the activity of a channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0016248 name: channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a channel via direct interaction with the channel. A channel catalyzes energy-independent facilitated diffusion, mediated by passage of a solute through a transmembrane aqueous pore or channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0016250 name: N-sulfoglucosamine sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-sulfo-D-glucosamine + H2O = D-glucosamine + sulfate." [EC:3.10.1.1] synonym: "2-desoxy-D-glucoside-2-sulphamate sulphohydrolase (sulphamate sulphohydrolase)" EXACT [EC:3.10.1.1] synonym: "heparin sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "N-sulfo-D-glucosamine sulfohydrolase activity" EXACT [EC:3.10.1.1] synonym: "N-sulphoglucosamine sulphohydrolase activity" EXACT [] synonym: "sulfoglucosamine sulfamidase activity" EXACT [EC:3.10.1.1] synonym: "sulphamidase activity" EXACT [EC:3.10.1.1] xref: EC:3.10.1.1 xref: MetaCyc:N-SULFOGLUCOSAMINE-SULFOHYDROLASE-RXN xref: reactome:R-HSA-1678708 "SGSH hydrolyses Heparan sulfate chain(2)" xref: reactome:R-HSA-2090043 "SGSH hydrolyses Heparan sulfate chain(7)" xref: RHEA:17881 is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0016251 name: RNA polymerase II general transcription initiation factor activity namespace: molecular_function alt_id: GO:0000983 alt_id: GO:0001075 alt_id: GO:0003703 def: "An activity that contributes to transcription start site selection and transcription initiation of genes transcribed by RNA polymerase II. The general transcription factors for RNA polymerase II include TFIIB, TFIID, TFIIE, TFIIF, TFIIH and TATA-binding protein (TBP)." [GOC:txnOH-2018, PMID:10384286, PMID:25693126] comment: General transcription factors assemble with the RNA polymerase at promoter DNA to form the pre-initiation complex (PIC), bind to and open promoter DNA, initiate RNA synthesis and stimulate the escape of the polymerase from the promoter. Not all subunits of the general transcription factor are necessarily present in all promoters to initiate transcription. The distinction between general transcription factors and DNA-binding transcription factors is that the latter modulate the selection of which genes are expressed under specific conditions, while general transcription factors belong to the constitutive machinery required for transcription to occur. synonym: "basal RNA polymerase II transcription factor activity" EXACT [] synonym: "general RNA polymerase II transcription factor activity" EXACT [] synonym: "GTF2 activity" EXACT [] synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity" RELATED [] synonym: "RNA polymerase II core promoter sequence-specific DNA binding transcription factor activity involved in preinitiation complex assembly" RELATED [] synonym: "sequence-specific core promoter binding RNA polymerase II transcription factor activity involved in preinitiation complex assembly" RELATED [] synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific binding involved in preinitiation complex assembly" RELATED [] synonym: "transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding" RELATED [] is_a: GO:0140223 ! general transcription initiation factor activity [Term] id: GO:0016252 name: obsolete nonspecific RNA polymerase II transcription factor activity namespace: molecular_function def: "OBSOLETE. Any function that supports transcription of genes by RNA polymerase II, and is not specific to a particular gene or gene set." [GOC:jl] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "nonspecific RNA polymerase II transcription factor activity" EXACT [] is_obsolete: true consider: GO:0006366 consider: GO:0016251 [Term] id: GO:0016254 name: preassembly of GPI anchor in ER membrane namespace: biological_process def: "The stepwise addition of the components of the GPI anchor on to phosphatidylinositol lipids in the endoplasmic reticulum membrane." [ISBN:0879695595] synonym: "preassembly of GPI anchor in endoplasmic reticulum membrane" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016255 name: attachment of GPI anchor to protein namespace: biological_process def: "A transamidation reaction that results in the cleavage of the polypeptide chain and the concomitant transfer of the GPI anchor to the newly formed carboxy-terminal amino acid of the anchored protein. The cleaved C-terminal contains the C-terminal GPI signal sequence of the newly synthesized polypeptide chain." [ISBN:0879695595] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0006506 ! GPI anchor biosynthetic process [Term] id: GO:0016256 name: N-glycan processing to lysosome namespace: biological_process def: "The modification of high-mannose N-glycans by UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase and the subsequent removal of the N-acetylglucosamine residues yielding mannose-6-P that occurs in the ER-Golgi apparatus to N-glycans destined for the lysosome." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing relationship: part_of GO:0006622 ! protein targeting to lysosome [Term] id: GO:0016257 name: N-glycan processing to secreted and cell-surface N-glycans namespace: biological_process def: "The modification of high-mannose (Man9-Asn) N-glycans by mannosyl-oligosaccharide 1,2-alpha-mannosidase. This may result in Man8GlcNAc2-Asn N-glycans (which in yeast may be subsequently modified by the addition of further mannose residues) or Man5GlcNAc2-Asn N-glycans that are substrates for further diversification in the Golgi apparatus." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016258 name: N-glycan diversification namespace: biological_process def: "The generation, in the Golgi apparatus, of side chain diversity from high mannose Man5GlcNAc2-Asn N-glycans by specific glycosyltransferases and glycosidases." [ISBN:0879695595] is_a: GO:0006491 ! N-glycan processing [Term] id: GO:0016259 name: selenocysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0016260 name: selenocysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine anabolism" EXACT [] synonym: "selenocysteine biosynthesis" EXACT [] synonym: "selenocysteine formation" EXACT [] synonym: "selenocysteine synthesis" EXACT [] is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0016259 ! selenocysteine metabolic process [Term] id: GO:0016261 name: selenocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of selenocysteine, an essential component of glutathione peroxidase and some other proteins." [GOC:go_curators, ISBN:0198506732] synonym: "selenocysteine breakdown" EXACT [] synonym: "selenocysteine catabolism" EXACT [] synonym: "selenocysteine degradation" EXACT [] is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0016259 ! selenocysteine metabolic process [Term] id: GO:0016262 name: protein N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0016253 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein." [EC:2.4.1.94] synonym: "N-GlcNAc transferase activity" EXACT [EC:2.4.1.94] synonym: "UDP-N-acetyl-D-glucosamine:protein beta-N-acetyl-D-glucosaminyl-transferase activity" EXACT [] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphospho-N-acetylglucosamine:polypeptide beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-protein acetylglucosaminyltransferase activity" EXACT [] xref: EC:2.4.1.94 xref: MetaCyc:2.4.1.94-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016263 name: glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of a galactosyl residue to a non-reducing O-linked N-acetylgalactosamine residue in an O-glycan." [EC:2.4.1.122, GOC:ma] synonym: "Core 1 GalT" RELATED [] synonym: "UDP-galactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "UDPgalactose:glycoprotein-N-acetyl-D-galactosamine 3-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.122] synonym: "uridine diphosphogalactose-mucin beta-(1->3)-galactosyltransferase activity" EXACT [EC:2.4.1.122] xref: EC:2.4.1.122 xref: MetaCyc:2.4.1.122-RXN xref: reactome:R-HSA-1964505 "C1GALT1 transfers Galactose to the Tn antigen forming Core 1 glycoproteins (T antigens)" is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0016264 name: gap junction assembly namespace: biological_process def: "Assembly of gap junctions, which are found in most animal tissues, and serve as direct connections between the cytoplasms of adjacent cells. They provide open channels through the plasma membrane, allowing ions and small molecules (less than approximately a thousand daltons) to diffuse freely between neighboring cells, but preventing the passage of proteins and nucleic acids." [GOC:jid, ISBN:0716731363] is_a: GO:0007043 ! cell-cell junction assembly [Term] id: GO:0016265 name: obsolete death namespace: biological_process def: "OBSOLETE. A permanent cessation of all vital functions: the end of life; can be applied to a whole organism or to a part of an organism." [GOC:mah, GOC:mtg_apoptosis, ISBN:0877797099] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. xref: Wikipedia:Death is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0016266 name: O-glycan processing namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form a core O-glycan structure." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0006493 ! protein O-linked glycosylation [Term] id: GO:0016267 name: O-glycan processing, core 1 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 1 O-glycan structure, Gal-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016268 name: O-glycan processing, core 2 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 2 O-glycan structure, GlcNAc-beta-(1->6)[Gal-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016269 name: O-glycan processing, core 3 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 3 O-glycan structure, GlcNAc-beta-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016270 name: O-glycan processing, core 4 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 4 O-glycan structure, GlcNAc-beta-(1->6)[GalNAc-beta-(1->3)]-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0016271 name: obsolete tissue death namespace: biological_process def: "OBSOLETE. A permanent cessation of all vital functions of a tissue." [GOC:dph, GOC:mtg_apoptosis] comment: This term was made obsolete because it refers to a phenotype. When death of a cell or tissue is a result of a true biological process, this should be captured using 'programmed cell death' or one of its descendants. is_obsolete: true consider: GO:0008219 consider: GO:0012501 [Term] id: GO:0016272 name: prefoldin complex namespace: cellular_component def: "A multisubunit chaperone that is capable of delivering unfolded proteins to cytosolic chaperonin, which it acts as a cofactor for. In humans, the complex is a heterohexamer of two PFD-alpha and four PFD-beta type subunits. In Saccharomyces cerevisiae, it also acts in the nucleus to regulate the rate of elongation by RNA polymerase II via a direct effect on histone dynamics." [GOC:jl, PMID:17384227, PMID:24068951, PMID:9630229] synonym: "GIM complex" NARROW [] xref: Wikipedia:Prefoldin is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0016273 name: arginine N-methyltransferase activity namespace: molecular_function def: "Enables the transfer of a methyl group from S-adenosyl-L-methionine to an amino group of an arginine residue." [GOC:mah] xref: EC:2.1.1.125 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016274 name: protein-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (protein)-arginine = S-adenosyl-L-homocysteine + (protein)-N-methyl-arginine." [GOC:mah, PMID:12351636] synonym: "PRMT activity" EXACT [] xref: EC:2.1.1 xref: reactome:R-HSA-191790 "Loading and methylation of Sm proteins onto SMN Complexes" xref: reactome:R-HSA-5205798 "PRMT1,PRMT6 methylate arginine-4 of histone H4" xref: reactome:R-HSA-5205820 "PRMT6 methylates arginine-4 of histone H2A (H2AR3)" xref: reactome:R-HSA-5205822 "CARM1 methylates arginine-18 (H3R17) of histone H3" xref: reactome:R-HSA-5205824 "CARM1, PRMT6 methylate arginine-3 of histone H3 (H3R2)" xref: reactome:R-HSA-5205867 "PRMT1 methylates arginine-12 of histone H2A (H2AR11)" xref: reactome:R-HSA-5218952 "PRMT5:WDR77, PRMT7 methylate arginine-3 of histone H3 (H3R2)" xref: reactome:R-HSA-5229010 "CARM1 methylates arginine-27 of histone H3 (H3R26)" xref: reactome:R-HSA-5229203 "PRMT6 methylates histone H2A arginine-30 (H2AR29)" xref: reactome:R-HSA-5661126 "PRMT1,PRMT6 methylate methyl-lysine-4 of histone H4" xref: reactome:R-HSA-8879123 "PRMT3 transfers 3xCH3 from 3xAdoMet to RPS2" xref: reactome:R-HSA-8934735 "PRMT1 arginine-methylates RUNX1" is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016273 ! arginine N-methyltransferase activity [Term] id: GO:0016275 name: [cytochrome c]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (cytochrome c)-arginine = S-adenosyl-L-homocysteine + (cytochrome c)-N(omega)-methyl-arginine." [EC:2.1.1.124, GOC:ma] synonym: "cytochrome c-arginine N-methyltransferase activity" EXACT [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine nomega-methyltransferasea" RELATED [EC:2.1.1.124] synonym: "S-adenosyl-L-methionine:cytochrome c-arginine omega-N-methyltransferasea" RELATED [EC:2.1.1.124] xref: EC:2.1.1.124 xref: MetaCyc:2.1.1.124-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016277 name: [myelin basic protein]-arginine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (myelin basic protein)-arginine = S-adenosyl-L-homocysteine + (myelin basic protein)-N(omega)-methyl-arginine." [PMID:6177833] synonym: "myelin basic protein methylase activity" EXACT [EC:2.1.1.126] synonym: "myelin basic protein methylase I" RELATED [EC:2.1.1.126] synonym: "myelin basic protein-arginine N-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "protein methylase I activity" BROAD [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.126] synonym: "S-adenosyl-L-methionine:myelin-basic-protein-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.126] is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0016278 name: lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue." [GOC:mah] xref: reactome:R-HSA-3222237 "SMYD2 methylates TP53" xref: reactome:R-HSA-6805730 "SETD9 methylates TP53" xref: reactome:R-HSA-6805740 "SETD8 methylates TP53" xref: reactome:R-HSA-6805755 "EHMT1:EHMT2 dimethylates TP53" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016279 name: protein-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the epsilon-amino group of a lysine residue in a protein substrate." [PMID:12054878] xref: EC:2.1.1 xref: reactome:R-HSA-212263 "PRC2 trimethylates histone H3 at lysine-27" xref: reactome:R-HSA-212269 "DNMT1,3A,3B:PRC2 methylates cytosine and histone H3" xref: reactome:R-HSA-8865237 "SETD6 methylates RELA in the NFkB complex" xref: reactome:R-HSA-8931858 "ETFBKMT transfers 3xCH3 from 3xAdoMet to ETFB" xref: reactome:R-HSA-8931974 "N6AMT2 transfers 3xCH3 from 3xAdoMet to EEF1A" xref: reactome:R-HSA-8932221 "METTL21A transfers 3xCH3 from 3xAdoMet to HSPA8" xref: reactome:R-HSA-8932243 "EEF2KMT transfers 3xCH3 from 3xAdoMet to EEF2" xref: reactome:R-HSA-8932275 "METTL22 transfers 3xCH3 from 3xAdoMet to KIN" xref: reactome:R-HSA-8932276 "VCPKMT (METTL21D) transfers 3xCH3 from 3xAdoMet to VCP" xref: reactome:R-HSA-8932413 "METTL10 transfers 3xCH3 from 3xAdoMet to EEF1A1" is_a: GO:0008276 ! protein methyltransferase activity is_a: GO:0016278 ! lysine N-methyltransferase activity [Term] id: GO:0016281 name: eukaryotic translation initiation factor 4F complex namespace: cellular_component def: "The eukaryotic translation initiation factor 4F complex is composed of eIF4E, eIF4A and eIF4G; it is involved in the recognition of the mRNA cap, ATP-dependent unwinding of the 5'-terminal secondary structure and recruitment of the mRNA to the ribosome." [GOC:hb, PMID:8449919] synonym: "eIF-4F" EXACT [] synonym: "eukaryotic translation initiation factor 4 complex" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0016282 name: eukaryotic 43S preinitiation complex namespace: cellular_component def: "A protein complex composed of the 40S ribosomal subunit plus eIF1A, eIF3, and eIF2-GTP-bound methionyl-initiator methionine tRNA." [GOC:hjd, PMID:15145049] synonym: "eukaryotic 43S pre-initiation complex" EXACT [] is_a: GO:0070993 ! translation preinitiation complex [Term] id: GO:0016284 name: obsolete alanine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from an oligopeptide or polypeptide." [GOC:jl] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "alanine aminopeptidase activity" EXACT [] xref: EC:3.4.11 is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0016285 name: obsolete cytosol alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferentially alanine, from a wide range of peptides, amides and arylamides." [EC:3.4.11.14] comment: This term was made obsolete because it represents a gene product and refers to cellular component information. synonym: "aminopolypeptidase activity" EXACT [EC:3.4.11.14] synonym: "arylamidase activity" NARROW [EC:3.4.11.14] synonym: "cytosol alanyl aminopeptidase activity" EXACT [] synonym: "cytosol aminopeptidase III activity" NARROW [EC:3.4.11.14] synonym: "human liver aminopeptidase" NARROW [EC:3.4.11.14] synonym: "liver aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "puromycin-sensitive aminopeptidase activity" NARROW [EC:3.4.11.14] synonym: "soluble alanyl aminopeptidase activity" EXACT [EC:3.4.11.14] synonym: "thiol-activated aminopeptidase activity" EXACT [EC:3.4.11.14] xref: EC:3.4.11.14 xref: MetaCyc:3.4.11.14-RXN is_obsolete: true consider: GO:0004177 consider: GO:0008235 [Term] id: GO:0016286 name: small conductance calcium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 2 to 20 picoSiemens that opens in response to stimulus by internal calcium ions. Small conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "SK calcium-activated potassium channel activity" EXACT [] synonym: "SK KCa channels" EXACT [] synonym: "small conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0016287 name: glycerone-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + glycerone phosphate = 1-acylglycerone 3-phosphate + CoA." [EC:2.3.1.42, RHEA:17657] synonym: "acyl-CoA:glycerone-phosphate O-acyltransferase activity" EXACT [EC:2.3.1.42] synonym: "dihydroxyacetone phosphate acyltransferase activity" EXACT [EC:2.3.1.42] xref: EC:2.3.1.42 xref: KEGG:R01013 xref: MetaCyc:2.3.1.42-RXN xref: reactome:R-HSA-1483002 "DHAP is converted to 1-acyl GO3P by GNPAT" xref: reactome:R-HSA-75879 "palmitoyl-CoA + DHAP => 1-palmitoylglycerone phosphate + CoASH" xref: RHEA:17657 is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0016289 name: CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: X-CoA + H2O = X + CoA; X may be any group." [GOC:ai] xref: EC:3.1.2 xref: reactome:R-HSA-193385 "Hydrolysis of choloyl-CoA to cholate and CoASH" xref: reactome:R-HSA-6809354 "NUDT7 hydrolyses CoA-SH to 3',5'-ADP and PPANT" is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016290 name: palmitoyl-CoA hydrolase activity namespace: molecular_function alt_id: GO:0016293 def: "Catalysis of the reaction: palmitoyl-CoA + H2O = CoA + palmitate." [EC:3.1.2.2] subset: goslim_chembl synonym: "fatty acyl thioesterase I" RELATED [EC:3.1.2.2] synonym: "long-chain fatty-acyl-CoA hydrolase activity" BROAD [] synonym: "palmitoyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmitoyl-CoA deacylase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase activity" EXACT [EC:3.1.2.2] synonym: "palmityl thioesterase I" RELATED [EC:3.1.2.2] synonym: "palmityl-CoA deacylase activity" EXACT [EC:3.1.2.2] xref: EC:3.1.2.2 xref: MetaCyc:PALMITOYL-COA-HYDROLASE-RXN xref: MetaCyc:PWY-5148 xref: RHEA:16645 is_a: GO:0047617 ! acyl-CoA hydrolase activity [Term] id: GO:0016295 name: myristoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: myristoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + myristate." [EC:3.1.2.14, MetaCyc:RXN-10727] synonym: "myristoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "myristoyl-ACP hydrolase activity" EXACT [] synonym: "tetradecanoyl-[acyl-carrier-protein] hydrolase activity" EXACT [] synonym: "tetradecanoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG:R08159 xref: MetaCyc:RXN-10727 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016296 name: palmitoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + palmitate." [EC:3.1.2.14, MetaCyc:RXN-9549] synonym: "palmitoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "palmitoyl-ACP hydrolase activity" EXACT [] xref: EC:3.1.2.14 xref: KEGG:R08162 xref: MetaCyc:RXN-9549 is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0016297 name: acyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function alt_id: GO:0010281 def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + a fatty acid." [EC:3.1.2.14, MetaCyc:RXN-7902] synonym: "acyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "acyl-ACP hydrolase activity" EXACT [] synonym: "acyl-ACP thioesterase activity" EXACT [] synonym: "acyl-ACP-hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl carrier protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "acyl-acyl-carrier-protein hydrolase activity" EXACT [EC:3.1.2.14] synonym: "S-acyl fatty acid synthase thioesterase activity" EXACT [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:RXN-7902 xref: reactome:R-HSA-5655955 "OLAH hydrolyzes decanoyl-FASN dimer to DECA and FASN dimer" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0016298 name: lipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a lipid or phospholipid." [GOC:mah] subset: goslim_aspergillus subset: goslim_chembl xref: EC:3.1.1 xref: reactome:R-HSA-163402 "diacylglycerol + H2O -> 2-acylglycerol + fatty acid" xref: reactome:R-HSA-163432 "cholesterol ester + H2O -> cholesterol + fatty acid" is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016299 name: obsolete regulator of G-protein signaling activity namespace: molecular_function def: "OBSOLETE. Inhibits signal transduction the GTPase activity of G-protein alpha subunits, thereby driving them into their inactive GDP-bound form." [GOC:curators] comment: This term was made obsolete because it refers to a combination of a function and a process. synonym: "regulator of G protein signaling activity" EXACT [] synonym: "regulator of G protein signalling activity" EXACT [] synonym: "regulator of G-protein signaling activity" EXACT [] synonym: "regulator of G-protein signalling activity" EXACT [] synonym: "RGS" EXACT [] is_obsolete: true consider: GO:0005095 consider: GO:0034260 consider: GO:0045744 [Term] id: GO:0016300 name: tRNA (uracil) methyltransferase activity namespace: molecular_function alt_id: GO:0016431 def: "Catalysis of the transfer of a methyl group from a donor to a uracil residue in a tRNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). synonym: "tRNA (uridine) methyltransferase activity" EXACT [] is_a: GO:0008175 ! tRNA methyltransferase activity [Term] id: GO:0016301 name: kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [ISBN:0198506732] comment: Note that this term encompasses all activities that transfer a single phosphate group; although ATP is by far the most common phosphate donor, reactions using other phosphate donors are included in this term. subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_plant subset: goslim_yeast synonym: "phosphokinase activity" EXACT [] xref: reactome:R-HSA-109822 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y427-SHC1" xref: reactome:R-HSA-109823 "MAPK3,(MAPK1) phosphorylates GRB2-1:SOS1:p-Y-IRS1,p-Y-IRS2" xref: reactome:R-HSA-111898 "Phosphorylation of cPLA2 by ERK-2" xref: reactome:R-HSA-112381 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: reactome:R-HSA-139908 "Phosphorylation of DLC2 by MAPK8" xref: reactome:R-HSA-139918 "Phosphorylation of BIM by JNK" xref: reactome:R-HSA-165692 "Phosphorylation of 4E-BP1 by activated mTORC1" xref: reactome:R-HSA-165718 "mTORC1 phosphorylation of RPS6KB1 (S6K)" xref: reactome:R-HSA-165726 "Phosphorylation of Ribosomal protein S6 by activated S6K1" xref: reactome:R-HSA-165758 "Phosphorylation and inactivation of eEF2K by activated S6K1" xref: reactome:R-HSA-165766 "Phosphorylation and activation of eIF4G by activated S6K1" xref: reactome:R-HSA-165777 "Phosphorylation and activation of eIF4B by activated S6K1" xref: reactome:R-HSA-167084 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by P-TEFb complex" xref: reactome:R-HSA-167098 "Phosphorylation (Ser5) of RNA pol II CTD" xref: reactome:R-HSA-167191 "Hyperphosphorylation (Ser2) of RNA Pol II CTD by the P-TEFb(Cyclin T1:Cdk9) complex" xref: reactome:R-HSA-170055 "Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes" xref: reactome:R-HSA-170070 "Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes" xref: reactome:R-HSA-170076 "CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes" xref: reactome:R-HSA-170087 "CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes" xref: reactome:R-HSA-170116 "Myt-1 mediated phosphorylation of Cyclin A:Cdc2" xref: reactome:R-HSA-170126 "Phosphorylation of Cyclin B1 in the CRS domain" xref: reactome:R-HSA-170156 "Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes" xref: reactome:R-HSA-170704 "Phosphorylation of DSIF by the P-TEFb(Cyclin T1:Cdk9) complex" xref: reactome:R-HSA-170706 "Phosphorylation of NEFL by the P-TEFb(Cyclin T1:Cdk9) complex" xref: reactome:R-HSA-174164 "Phosphorylation of Cyclin A:Cdk2 at Tyr 15" xref: reactome:R-HSA-1839091 "Cytosolic FGFR1 fusion protein-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-1839107 "BCR-FGFR1-associated PI3K phosphorylates PIP2 to PIP3." xref: reactome:R-HSA-1839110 "p-BCR-p-FGFR1 phosphorylates GAB2" xref: reactome:R-HSA-187949 "CAK-mediated phosphorylation of Cyclin A:Cdk2" xref: reactome:R-HSA-188350 "CAK-mediated phosphorylation of Cyclin E:Cdk2" xref: reactome:R-HSA-191636 "Phosphorylation of Cx43 by c-src" xref: reactome:R-HSA-195275 "Phosphorylation of APC component of the destruction complex" xref: reactome:R-HSA-195283 "Phosphorylation of phospho- (Ser45, Thr41) beta-catenin at Ser37 by GSK-3" xref: reactome:R-HSA-195287 "Phosphorylation of phospho-(Ser45 ) at Thr 41 by GSK-3" xref: reactome:R-HSA-195300 "Phosphorylation of phospho-(Ser45,Thr41,Ser37) at Ser33 by GSK-3" xref: reactome:R-HSA-195318 "Phosphorylation of beta-catenin at Ser45 by CK1 alpha" xref: reactome:R-HSA-201717 "CSNK2-mediated phosphorylation of DVL" xref: reactome:R-HSA-211583 "Partial autophosphorylation of PAK-2 at Ser-19, Ser-20, Ser-55, Ser-192, and Ser-197" xref: reactome:R-HSA-211650 "Autophosphorylation of PAK-2p34 in the activation loop" xref: reactome:R-HSA-2214351 "PLK1 phosphorylates GORASP1" xref: reactome:R-HSA-2294580 "PLK1 hyperphosphorylates Condensin II complex" xref: reactome:R-HSA-2529020 "CK2 phosphorylates condensin I subunits" xref: reactome:R-HSA-389762 "Phosphorylation of PD-1" xref: reactome:R-HSA-392752 "Phosphorylation of L1 by CK-II" xref: reactome:R-HSA-442724 "Phosphorylation of CREB1 by ribosomal protein S6 kinases (RSKs)" xref: reactome:R-HSA-445079 "Phosphorylation of L1 by ERK" xref: reactome:R-HSA-5654690 "FGFR1-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654692 "FGFR1- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654697 "FGFR2- and PTPN11- associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654701 "FGFR2-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654705 "FGFR3-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654709 "FGFR3- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654714 "FGFR4- and PTPN11-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5654717 "FGFR4-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5655235 "Activated FGFR4 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5655289 "Activated FGFR3 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5655290 "Activated FGFR1 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5655323 "Activated FGFR2 mutant-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-5668545 "NIK autophosphorylates on T559" xref: reactome:R-HSA-6788855 "FN3KRP phosphorylates PsiAm, RibAm" xref: reactome:R-HSA-6788867 "FN3K phosphorylates ketosamines" xref: reactome:R-HSA-6814409 "CK2 phosphorylates PDCL" xref: reactome:R-HSA-68954 "Mcm2-7 is phosphorylated by DDK" xref: reactome:R-HSA-69195 "Phosphorylation of Cyclin E:CDK2 complexes by WEE1" xref: reactome:R-HSA-69604 "Phosphorylation of Cdc25A at Ser-123 by Chk1" xref: reactome:R-HSA-75028 "Phosphorylation of Wee1 kinase by Chk1" xref: reactome:R-HSA-75809 "Phosphorylation of Cdc25C at Ser216 by CHEK2" xref: reactome:R-HSA-77071 "Phosphorylation (Ser5) of RNA pol II CTD" xref: reactome:R-HSA-8853323 "Activated FGFR3 fusion-associated PI3K phosphorylates PIP2 to PIP3" xref: reactome:R-HSA-8942836 "CDK4/6:CCND complexes are activated by T-loop phosphorylation of CDK4/6" xref: reactome:R-HSA-8948039 "FUNDC1 is phosphorylated by CK2" xref: reactome:R-HSA-8948143 "p-S13, FUNDC1 is phosphorylated by CK2 at Tyr18" xref: reactome:R-HSA-8948146 "FUNDC1 is phosphorylated by ULK1 at Ser17" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016303 name: 1-phosphatidylinositol-3-kinase activity namespace: molecular_function alt_id: GO:0004429 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol + ATP = a 1-phosphatidyl-1D-myo-inositol 3-phosphate + ADP + 2 H(+)." [EC:2.7.1.137, RHEA:12709] synonym: "1-phosphatidylinositol 3-kinase activity" EXACT [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 3-phosphotransferase activity" EXACT [EC:2.7.1.137] synonym: "phosphatidylinositol 3-kinase activity, class I" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class II" NARROW [] synonym: "phosphatidylinositol 3-kinase activity, class III" NARROW [] synonym: "phosphatidylinositol 3-kinase, class I, catalyst activity" NARROW [] synonym: "PI3-kinase activity" EXACT [EC:2.7.1.137] synonym: "PI3K" EXACT [] synonym: "PtdIns-3-kinase activity" EXACT [EC:2.7.1.137] synonym: "type I phosphatidylinositol kinase activity" NARROW [EC:2.7.1.137] synonym: "type III phosphoinositide 3-kinase activity" NARROW [EC:2.7.1.137] synonym: "Vps34p" RELATED [EC:2.7.1.137] xref: EC:2.7.1.137 xref: KEGG:R03362 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-3-KINASE-RXN xref: reactome:R-HSA-109699 "PI3K-containing complexes phosphorylate PIP2 to PIP3" xref: reactome:R-HSA-1675939 "PI is phosphorylated to PI3P by PIK3C2A/3 at the early endosome membrane" xref: reactome:R-HSA-1675961 "PI is phosphorylated to PI3P by PIK3C2A/3 at the Golgi membrane" xref: reactome:R-HSA-1676024 "PI is phosphorylated to PI3P by PIK3C2A/3 at the late endosome membrane" xref: reactome:R-HSA-5672012 "Beclin-1 complex phosphorylates PtdIns" xref: reactome:R-HSA-6798174 "PIK3C3:PIK3R4 phosphorylates PI to PI3P" xref: RHEA:12709 is_a: GO:0035004 ! phosphatidylinositol 3-kinase activity is_a: GO:0052742 ! phosphatidylinositol kinase activity [Term] id: GO:0016304 name: obsolete phosphatidylinositol 3-kinase activity, class I namespace: molecular_function def: "OBSOLETE. A heterodimeric phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol, phosphatidylinositol-4-phosphate or phosphatidylinositol-4,5-bisphosphate. Also possesses intrinsic protein kinase activity." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class I" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0016305 name: obsolete phosphatidylinositol 3-kinase activity, class II namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can phosphorylate phosphatidylinositol and phosphatidylinositol-4-phosphate; the human form can phosphorylate phosphatidylinositol-4,5-bisphosphate in the presence of phosphatidylserine." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class II" EXACT [] synonym: "PI3KC2" EXACT [] is_obsolete: true consider: GO:0016303 consider: GO:0035005 consider: GO:0046934 [Term] id: GO:0016306 name: obsolete phosphatidylinositol 3-kinase activity, class III namespace: molecular_function def: "OBSOLETE. A phosphoinositide 3-kinase which can only phosphorylate phosphatidylinositol." [PMID:9759495] comment: This term was made obsolete because it represents a class of gene products. synonym: "phosphatidylinositol 3-kinase activity, class III" EXACT [] is_obsolete: true replaced_by: GO:0016303 [Term] id: GO:0016307 name: phosphatidylinositol phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a phosphatidylinositol phosphate = ADP + a phosphatidylinositol bisphosphate." [EC:2.7.1.-, PMID:9759495] synonym: "phosphatidylinositol monophosphate kinase activity" EXACT [GOC:bf] is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0016308 name: 1-phosphatidylinositol-4-phosphate 5-kinase activity namespace: molecular_function alt_id: GO:0004431 alt_id: GO:0045215 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4-phosphate + ATP = 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + ADP + 2 H(+)." [EC:2.7.1.68, RHEA:14425] synonym: "1-phosphatidylinositol-4-phosphate kinase activity" BROAD [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA" NARROW [] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB" NARROW [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-4-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.68] synonym: "diphosphoinositide kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol 4-phosphate kinase activity" BROAD [EC:2.7.1.68] synonym: "phosphatidylinositol-4-phosphate 5-kinase activity" EXACT [EC:2.7.1.68] synonym: "PIP kinase activity" BROAD [EC:2.7.1.68] synonym: "PIP5K" EXACT [] synonym: "PtdIns(4)P-5-kinase activity" EXACT [EC:2.7.1.68] synonym: "type I PIP kinase activity" NARROW [EC:2.7.1.68] xref: EC:2.7.1.68 xref: KEGG:R03469 xref: MetaCyc:2.7.1.68-RXN xref: reactome:R-HSA-1676082 "PI4P is phosphorylated to PI(4,5)P2 by PIP5K1A-C at the plasma membrane" xref: reactome:R-HSA-3772436 "DVL-associated PIP5K1B phosphorylates PI4P to PI(4,5)P2" xref: reactome:R-HSA-8868066 "PIP5K1C phosphorylates PI(4)P to PI(4,5)P2" xref: RHEA:14425 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016309 name: 1-phosphatidylinositol-5-phosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate." [EC:2.7.1.149] synonym: "1-phosphatidylinositol-5-phosphate kinase" BROAD [] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase activity" EXACT [EC:2.7.1.149] synonym: "PIP4K" EXACT [] synonym: "type II PIP kinase activity" NARROW [EC:2.7.1.149] xref: EC:2.7.1.149 xref: MetaCyc:2.7.1.149-RXN xref: reactome:R-HSA-1675776 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers at the plasma membrane" xref: reactome:R-HSA-6811522 "PI5P is phosphorylated to PI(4,5)P2 by PIP4K2 dimers in the nucleus" xref: RHEA:12280 is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0016310 name: phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide." [ISBN:0198506732] subset: goslim_chembl subset: goslim_metagenomics xref: Wikipedia:Phosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016311 name: dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric (ester or anhydride) residues from a molecule." [ISBN:0198506732] xref: Wikipedia:Dephosphorylation is_a: GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0016312 name: inositol bisphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol bisphosphate + H2O = myo-inositol phosphate + phosphate." [GOC:hb] xref: EC:3.1.3 xref: reactome:R-HSA-6809561 "I(1,3)P2 is dephosphorylated into I1P by MTMR7" xref: reactome:R-HSA-6809565 "I(1,3)P2 is dephosphorylated into I1P by MTMR7:MTMR9" is_a: GO:0052745 ! inositol phosphate phosphatase activity [Term] id: GO:0016313 name: obsolete inositol-1,4,5-trisphosphate phosphatase namespace: molecular_function def: "OBSOLETE. The removal of one of the phosphate groups from an inositol triphosphate to produce an inositol bisphosphate." [GOC:hb] comment: This term was made obsolete because it is a redundant grouping term with only one child. synonym: "inositol-1,4,5-trisphosphate phosphatase" EXACT [] is_obsolete: true consider: GO:0046030 [Term] id: GO:0016314 name: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylinositol-3,4,5-trisphosphate + H2O = phosphatidylinositol-4,5-bisphosphate + phosphate." [EC:3.1.3.67] synonym: "1-phosphatidyl-1D-myo-inositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "MMAC1" RELATED [EC:3.1.3.67] synonym: "phosphatidylinositol-3,4,5-trisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.67] synonym: "PI(3)P 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PI(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] synonym: "PtdIns(3,4,5)P3 3-phosphatase activity" EXACT [GOC:mah, PMID:15249580] xref: EC:3.1.3.67 xref: MetaCyc:3.1.3.67-RXN xref: reactome:R-HSA-199456 "PTEN dephosphorylates PIP3" xref: reactome:R-HSA-202237 "Hydrolysis of PIP3 to PI(3,4)P2" xref: RHEA:25017 is_a: GO:0034594 ! phosphatidylinositol trisphosphate phosphatase activity [Term] id: GO:0016316 name: phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity namespace: molecular_function alt_id: GO:0004440 def: "Catalysis of the reaction: 1-phosphatidyl-myo-inositol 3,4-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 3-phosphate + phosphate." [EC:3.1.3.66, GOC:hb] synonym: "1-phosphatidyl-1D-myo-inositol-3,4-bisphosphate 4-phosphohydrolase activity" EXACT [EC:3.1.3.66] synonym: "inositol polyphosphate 4-phosphatase type II activity" RELATED [EC:3.1.3.66] xref: EC:3.1.3.66 xref: MetaCyc:3.1.3.66-RXN xref: reactome:R-HSA-1676162 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the early endosome membrane" xref: reactome:R-HSA-1676164 "PI(3,4)P2 is dephosphorylated to PI3P by INPP4A/B at the plasma membrane" is_a: GO:0034596 ! phosphatidylinositol phosphate 4-phosphatase activity is_a: GO:0106017 ! phosphatidylinositol-3,4-bisphosphate phosphatase activity [Term] id: GO:0016318 name: ommatidial rotation namespace: biological_process def: "The process in which photoreceptors are arranged in ommatidia in the dorsal and ventral fields to be mirror images. The polarity is established in the imaginal discs concurrently with cell fate specification." [PMID:10725247] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity [Term] id: GO:0016319 name: mushroom body development namespace: biological_process def: "The process whose specific outcome is the progression of the mushroom body over time, from its formation to the mature structure. The mushroom body is composed of the prominent neuropil structures of the insect central brain, thought to be crucial for olfactory associated learning. These consist mainly of a bulbous calyx and tightly packaged arrays of thin parallel fibers of the Kenyon cells." [PMID:8790424] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0016320 name: endoplasmic reticulum membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the endoplasmic reticulum." [GOC:elh, GOC:jid] synonym: "ER membrane fusion" EXACT [] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0016321 name: female meiosis chromosome segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a female." [GOC:ai] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007143 ! female meiotic nuclear division [Term] id: GO:0016322 name: neuron remodeling namespace: biological_process def: "The developmentally regulated remodeling of neuronal projections such as pruning to eliminate the extra dendrites and axons projections set up in early stages of nervous system development." [GOC:hb] synonym: "axon pruning" NARROW [GOC:sart, PMID:18267091] synonym: "neuronal remodeling" EXACT [] is_a: GO:0042551 ! neuron maturation [Term] id: GO:0016323 name: basolateral plasma membrane namespace: cellular_component def: "The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0098590 ! plasma membrane region [Term] id: GO:0016324 name: apical plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the apical end of the cell." [GOC:curators] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0016325 name: oocyte microtubule cytoskeleton organization namespace: biological_process alt_id: GO:0048130 def: "Formation and maintenance of a polarized microtubule array originating from a microtubule-organizing center (MTOC) in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11231123] synonym: "oocyte microtubule cytoskeleton organisation" EXACT [GOC:curators] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0030951 ! establishment or maintenance of microtubule cytoskeleton polarity relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0016326 name: obsolete kinesin motor activity namespace: molecular_function def: "OBSOLETE. The hydrolysis of ATP (and GTP) that drives the microtubular motor along microtubules." [GOC:hb] comment: This term was made obsolete because it represents a gene product. synonym: "kinesin motor activity" EXACT [] is_obsolete: true replaced_by: GO:0003777 [Term] id: GO:0016327 name: apicolateral plasma membrane namespace: cellular_component def: "The apical end of the lateral plasma membrane of epithelial cells." [GOC:hb] synonym: "apical lateral plasma membrane" EXACT [PMID:24496625] is_a: GO:0098590 ! plasma membrane region [Term] id: GO:0016328 name: lateral plasma membrane namespace: cellular_component def: "The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells." [GOC:hb, GOC:mah, GOC:pr] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0016329 name: obsolete apoptosis regulator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly regulate any step in the process of apoptosis." [GOC:jl] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0042981 [Term] id: GO:0016330 name: second mitotic wave involved in compound eye morphogenesis namespace: biological_process def: "A discrete cell cycle in the third instar eye imaginal disc after progression of the morphogenetic furrow that contributes to compound eye morphogenesis. It is essential for generation of a sufficient pool of uncommitted cells to develop complete ommatidia." [PMID:11257224] synonym: "second mitotic wave during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0000278 ! mitotic cell cycle relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0016331 name: morphogenesis of embryonic epithelium namespace: biological_process def: "The process in which the anatomical structures of embryonic epithelia are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0016332 name: establishment or maintenance of polarity of embryonic epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization of epithelial cells in an embryo." [GOC:isa_complete, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016331 ! morphogenesis of embryonic epithelium [Term] id: GO:0016333 name: morphogenesis of follicular epithelium namespace: biological_process def: "The process in which the anatomical structures of a follicular epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0016334 name: establishment or maintenance of polarity of follicular epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized follicular epithelial sheet." [GOC:bf, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016333 ! morphogenesis of follicular epithelium [Term] id: GO:0016335 name: morphogenesis of larval imaginal disc epithelium namespace: biological_process def: "The process in which the anatomical structures of a larval imaginal disc epithelium are generated and organized." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0002168 ! instar larval development relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0016336 name: establishment or maintenance of polarity of larval imaginal disc epithelium namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of a polarized larval imaginal disc epithelium." [GOC:jl, GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity relationship: part_of GO:0016335 ! morphogenesis of larval imaginal disc epithelium [Term] id: GO:0016338 name: calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0016339 name: calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules namespace: biological_process def: "The attachment of one cell to another cell via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-dependent cell adhesion molecule activity" RELATED [] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules [Term] id: GO:0016340 name: calcium-dependent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that require the presence of calcium for the interaction." [GOC:hb] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0016341 name: obsolete other collagen namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "other collagen" EXACT [] is_obsolete: true replaced_by: GO:0005581 [Term] id: GO:0016342 name: catenin complex namespace: cellular_component def: "Complex of peripheral cytoplasmic proteins (alpha-, beta- and gamma-catenin) that interact with the cytoplasmic region of uvomorulin/E-cadherin to connect it to the actin cytoskeleton." [ISBN:0198599323] is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0019897 ! extrinsic component of plasma membrane [Term] id: GO:0016343 name: obsolete cytoskeletal anchoring activity namespace: molecular_function def: "OBSOLETE. The direct or indirect linkage of cytoskeletal filaments to the plasma membrane." [ISBN:0198599323] comment: This term was made obsolete because it represents a biological process. synonym: "cytoskeletal anchoring activity" EXACT [] is_obsolete: true replaced_by: GO:0007016 [Term] id: GO:0016344 name: meiotic chromosome movement towards spindle pole namespace: biological_process def: "The cell cycle process in which the directed movement of chromosomes from the center of the spindle towards the spindle poles takes place, mediated by the shortening of microtubules attached to the chromosomes. This occurs during meiosis." [GOC:ai] synonym: "chromosome migration to spindle pole during meiosis" EXACT [] synonym: "chromosome movement towards spindle pole during meiosis" EXACT [] synonym: "meiotic chromosome movement" BROAD [] synonym: "meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0051305 ! chromosome movement towards spindle pole is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0016345 name: female meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during female meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during female meiosis" EXACT [] synonym: "female meiotic chromosome movement" BROAD [] synonym: "female meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0016321 ! female meiosis chromosome segregation [Term] id: GO:0016346 name: male meiotic chromosome movement towards spindle pole namespace: biological_process def: "The directed movement of chromosomes in the center of the spindle towards the spindle poles, mediated by the shortening of microtubules attached to the chromosomes, during male meiosis." [GOC:ai] synonym: "chromosome movement towards spindle pole during male meiosis" EXACT [] synonym: "male meiotic chromosome movement" BROAD [] synonym: "male meiotic chromosome movement to spindle pole" EXACT [] is_a: GO:0016344 ! meiotic chromosome movement towards spindle pole is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0007060 ! male meiosis chromosome segregation [Term] id: GO:0016347 name: obsolete calcium-independent cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "calcium-independent cell adhesion molecule activity" EXACT [] is_obsolete: true consider: GO:0005515 consider: GO:0007161 consider: GO:0016021 consider: GO:0016338 [Term] id: GO:0016348 name: imaginal disc-derived leg joint morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an imaginal disc-derived leg joint are generated and organized. The leg joint is a flexible region that separates the rigid sections of a leg to allow movement in a controlled manner. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0009886 ! post-embryonic animal morphogenesis relationship: part_of GO:0036011 ! imaginal disc-derived leg segmentation [Term] id: GO:0016351 name: obsolete drug susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "drug susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0016352 name: obsolete insecticide susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "insecticide susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0016353 name: obsolete carbamate susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "carbamate susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0016354 name: obsolete cyclodiene susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "cyclodiene susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0016355 name: obsolete DDT susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. synonym: "DDT susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0016356 name: obsolete organophosphorus susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "organophosphorus susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0016357 name: obsolete pyrethroid susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "pyrethroid susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0016358 name: dendrite development namespace: biological_process def: "The process whose specific outcome is the progression of the dendrite over time, from its formation to the mature structure." [GOC:aruk, GOC:bc, GOC:jl, ISBN:0198506732, PMID:22683681] is_a: GO:0031175 ! neuron projection development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0016360 name: sensory organ precursor cell fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a sensory organ precursor cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "sense organ precursor cell fate determination" EXACT [GOC:dph] is_a: GO:0060582 ! cell fate determination involved in pattern specification relationship: part_of GO:0008052 ! sensory organ boundary specification [Term] id: GO:0016361 name: activin receptor activity, type I namespace: molecular_function def: "Combining with activin-bound type II activin receptor to initiate a change in cell activity; upon binding, acts as a downstream transducer of activin signals." [GOC:mah, PMID:8622651] synonym: "type I activin receptor activity" EXACT [] is_a: GO:0017002 ! activin-activated receptor activity [Term] id: GO:0016362 name: activin receptor activity, type II namespace: molecular_function def: "Combining with activin to initiate a change in cell activity; upon ligand binding, binds to and catalyses the phosphorylation of a type I activin receptor." [GOC:mah, PMID:8622651] synonym: "type II activin receptor activity" EXACT [] xref: reactome:R-HSA-201443 "Type II receptor phosphorylates type I receptor" is_a: GO:0017002 ! activin-activated receptor activity [Term] id: GO:0016363 name: nuclear matrix namespace: cellular_component def: "The dense fibrillar network lying on the inner side of the nuclear membrane." [ISBN:0582227089] synonym: "nucleoskeleton" EXACT [] xref: Wikipedia:Nuclear_matrix is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0016401 name: palmitoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + O2 = trans-2,3-dehydropalmitoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3 is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016402 name: pristanoyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pristanoyl-CoA + O2 = trans-2,3-dehydropristanoyl-CoA + hydrogen peroxide." [GOC:jsg] xref: EC:1.3.3 xref: reactome:R-HSA-389889 "ACOX2:FAD, ACOXL:FAD oxidise (2S)-pristanoyl-CoA to trans-2,3-dehydropristanoyl-CoA" xref: reactome:R-HSA-389891 "(2S)-pristanoyl-CoA + O2 => trans-2,3-dehydropristanoyl-CoA + H2O2 (ACOX3)" is_a: GO:0003997 ! acyl-CoA oxidase activity [Term] id: GO:0016403 name: dimethylargininase activity namespace: molecular_function def: "Catalysis of the reaction: N(G),N(G)-dimethyl-L-arginine + H2O = dimethylamine + L-citrulline." [EC:3.5.3.18] synonym: "dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "N(G),N(G)-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethyl-L-arginine dimethylamidohydrolase activity" EXACT [EC:3.5.3.18] synonym: "NG,NG-dimethylarginine dimethylaminohydrolase activity" EXACT [EC:3.5.3.18] xref: EC:3.5.3.18 xref: MetaCyc:DIMETHYLARGININASE-RXN xref: reactome:R-HSA-5693373 "DDAH1,2 hydrolyses ADMA to DMA and L-Cit" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016404 name: 15-hydroxyprostaglandin dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-11-alpha,15-dihydroxy-9-oxoprost-13-enoate + NAD+ = (5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-13-enoate + NADH + H+." [EC:1.1.1.141] synonym: "(5Z,13E)-(15S)-11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "11alpha,15-dihydroxy-9-oxoprost-13-enoate:NAD+ 15-oxidoreductase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-hydroxyprostanoic dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "15-OH-PGDH" RELATED [EC:1.1.1.141] synonym: "NAD+-dependent 15-hydroxyprostaglandin dehydrogenase (type I)" EXACT [EC:1.1.1.141] synonym: "NAD-specific 15-hydroxyprostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] synonym: "prostaglandin dehydrogenase activity" EXACT [EC:1.1.1.141] xref: EC:1.1.1.141 xref: MetaCyc:1.1.1.141-RXN xref: reactome:R-HSA-2161662 "PGD2/E2/F2a is oxidised to 15k-PGD2/E2/F2a by HPGD" xref: reactome:R-HSA-2161779 "LXA4 is oxidised to 15k-LXA4 by HPGD" xref: reactome:R-HSA-9023968 "HPGD dimer oxidises 18(S)-RvE1 to 18-oxo-RvE1" xref: reactome:R-HSA-9024766 "HPGD dimer oxidises RvD1 to 17(S)-oxo-RvD1 and 8-oxo-17(S)-RvD1" xref: RHEA:11876 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016405 name: CoA-ligase activity namespace: molecular_function def: "Catalysis of the reaction: substrate + ATP + CoASH = AMP + diphosphate + substrate-CoA." [GOC:ai] xref: reactome:R-HSA-159443 "benzoate + Coenzyme A + ATP => benzoyl-CoA + AMP + pyrophosphate" xref: reactome:R-HSA-159567 "salicylic acid + Coenzyme A + ATP => salicylate-CoA + AMP + pyrophosphate" xref: reactome:R-HSA-177157 "phenylacetate + Coenzyme A + ATP => phenylacetyl-CoA + AMP + pyrophosphate" xref: reactome:R-HSA-6798345 "GCAT:PXLP dimer ligates CoASH to 2A-3OB to form Gly and Ac-CoA" is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016406 name: carnitine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the carnitine molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016407 name: acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an acceptor molecule." [GOC:ai] synonym: "acetylase activity" EXACT [] xref: EC:2.3.1 xref: reactome:R-HSA-5628871 "BRD7 promotes EP300-mediated acetylation of TP53" xref: reactome:R-HSA-5660660 "p300 acetylates RELA subunit" xref: reactome:R-HSA-5682044 "KAT5 acetylates ATM at DNA DSBs" xref: reactome:R-HSA-6792712 "KAT5 acetylates ATM at shortened telomeres" xref: reactome:R-HSA-6805638 "KAT6A acetylates TP53" xref: reactome:R-HSA-73736 "Acetylation of SL1" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016408 name: C-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a carbon atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016409 name: palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl (CH3-[CH2]14-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1 xref: reactome:R-HSA-203567 "palmitoylation of eNOS" xref: reactome:R-HSA-5686304 "ZDHHC2 transfers PALM from PALM-CoA to CKAP4" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016410 name: N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 xref: reactome:R-HSA-177160 "phenylacetyl-CoA + glutamine => phenylacetyl glutamine + Coenzyme A" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016411 name: acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acylglycerol molecule." [GOC:ai] xref: reactome:R-HSA-1482647 "2-MAG and DAG are transacylated to TAG by PNPLA2/3" xref: reactome:R-HSA-1482654 "2-MAG is transacylated to DAG by PNPLA2/3" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016412 name: serine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the serine molecule." [GOC:ai] xref: EC:2.3.1.30 is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0016413 name: O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0016414 name: O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016415 ! octanoyltransferase activity [Term] id: GO:0016415 name: octanoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an octanoyl (CH3-[CH2]6-CO-) group to an acceptor molecule." [GOC:ai] xref: EC:2.3.1.181 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016416 name: O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] xref: reactome:R-HSA-2404137 "LRAT esterifies RBP1:atROL and FACYLs to atREs" xref: reactome:R-HSA-2453855 "LRAT esterifies RBP1:atROL and FACYLs to atREs" is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016417 name: S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016418 name: S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a sulfur atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.38 is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0016419 name: S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl group to a sulfur atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1.39 is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016420 ! malonyltransferase activity [Term] id: GO:0016420 name: malonyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a malonyl (HOOC-CH2-CO-) group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016421 name: CoA carboxylase activity namespace: molecular_function def: "Catalysis of the joining of a carboxyl group to a molecule that is attached to CoA, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:mah] is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0016422 name: mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m(7)G(5')pppAm = S-adenosyl-L-homocysteine + m(7)G(5')pppm(6)Am." [EC:2.1.1.62] synonym: "messenger ribonucleate 2'-O-methyladenosine NG-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.62] synonym: "S-adenosyl-L-methionine:mRNA (2'-O-methyladenosine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.62] xref: EC:2.1.1.62 xref: MetaCyc:2.1.1.62-RXN is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0016423 name: tRNA (guanine) methyltransferase activity namespace: molecular_function alt_id: GO:0016424 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylguanine." [EC:2.1.1.-] synonym: "tRNA (guanosine) methyltransferase activity" EXACT [] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016426 name: tRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methyladenine." [EC:2.1.1.-] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016427 name: tRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing methylcytosine." [EC:2.1.1.-] is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0016428 name: tRNA (cytosine-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylcytosine." [EC:2.1.1.29] synonym: "S-adenosyl-L-methionine:tRNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer ribonucleate cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] synonym: "transfer RNA cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.29] xref: reactome:R-HSA-6782388 "NSUN2 methylates cytidine-34, cytidine-48 of unspliced tRNA(Leu)(CAA)" xref: reactome:R-HSA-6782419 "TRDMT1 (DNMT2) methylates cytidine-38 of tRNA(Asp)" xref: reactome:R-HSA-6785409 "NSUN2 methylates cytidine-48 and cytidine-49 of tRNA(Asp)(GUC)" xref: reactome:R-HSA-6785438 "NSUN2 methylates cytidine-40, cytidine-48, cytidine-49, cytidine-50 of tRNA(GLY)(GCC)" xref: reactome:R-HSA-8932765 "NSUN6 methylates cytidine-72 in tRNA(Cys) and tRNA(Thr)" is_a: GO:0016427 ! tRNA (cytosine) methyltransferase activity [Term] id: GO:0016429 name: tRNA (adenine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methyladenine." [EC:2.1.1.36] synonym: "1-methyladenine transfer RNA methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "adenine-1-methylase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer ribonucleate adenine 1-methyltransferase activity" EXACT [EC:2.1.1.36] synonym: "transfer RNA (adenine-1) methyltransferase activity" EXACT [EC:2.1.1.36] xref: reactome:R-HSA-6783492 "TRMT6:TRMT61A methylate adenosine yielding 1-methyladenosine at nucleotide 58 of tRNA(Met)" xref: reactome:R-HSA-6787525 "TRMT61B methylates adenosine-58 in tRNA yielding 1-methyladenosine-58" xref: reactome:R-HSA-6787594 "TRMT10C:HSD17B10 (TRMT10C:SDR5C1) methylates adenosine-9 in tRNA yielding 1-methyladenosine-9" is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016430 name: tRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine." [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.55] synonym: "S-adenosyl-L-methionine:tRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.55] xref: EC:2.1.1.55 xref: MetaCyc:TRNA-ADENINE-N6--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016426 ! tRNA (adenine) methyltransferase activity [Term] id: GO:0016432 name: tRNA-uridine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA uridine = 5'-methylthioadenosine + tRNA 3-(3-amino-3-carboxypropyl)-uridine." [EC:2.5.1.25] synonym: "S-adenosyl-L-methionine:tRNA-uridine 3-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.25] xref: EC:2.5.1.25 xref: MetaCyc:2.5.1.25-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016433 name: rRNA (adenine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyladenine." [EC:2.1.1.-] xref: EC:2.1.1 is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016434 name: rRNA (cytosine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylcytosine." [EC:2.1.1.-] xref: EC:2.1.1 is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016435 name: rRNA (guanine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methylguanine." [EC:2.1.1.-] xref: EC:2.1.1 is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016436 name: rRNA (uridine) methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing methyluridine." [EC:2.1.1.-] xref: EC:2.1.1 is_a: GO:0008649 ! rRNA methyltransferase activity [Term] id: GO:0016437 name: tRNA cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.21] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "ATP(CTP):tRNA nucleotidyltransferase activity" BROAD [EC:2.7.7.21] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "CTP:tRNA cytidylyltransferase activity" BROAD [] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.21] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.21] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.21] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.21] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.21] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.21] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.21] xref: EC:2.7.7.21 xref: MetaCyc:TRNA-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0070567 ! cytidylyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016438 name: tRNA-queuosine beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + tRNA(Asp)-queuosine = GDP + tRNA(Asp)-O-5''-beta-D-mannosylqueuosine." [EC:2.4.1.110] synonym: "GDP-mannose:tRNAAsp-queuosine O-5''-beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.110] xref: EC:2.4.1.110 xref: MetaCyc:2.4.1.110-RXN is_a: GO:0000030 ! mannosyltransferase activity is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0016441 name: posttranscriptional gene silencing namespace: biological_process def: "The inactivation of gene expression by a posttranscriptional mechanism." [GOC:mah, PMID:15020054] synonym: "cosuppression" RELATED [] synonym: "post-transcriptional gene silencing" EXACT [GOC:vw] synonym: "PTGS" EXACT [] synonym: "quelling" EXACT [] xref: Wikipedia:Post_transcriptional_gene_silencing is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0016458 ! gene silencing is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0016442 name: RISC complex namespace: cellular_component def: "A ribonucleoprotein complex that contains members of the Argonaute family of proteins, small interfering RNAs (siRNAs) or microRNAs (miRNAs), and miRNA or siRNA-complementary mRNAs, in addition to a number of accessory factors. The RISC complex is involved in posttranscriptional repression of gene expression through downregulation of translation or induction of mRNA degradation." [PMID:10749213, PMID:15145345] synonym: "RNA-induced silencing complex" EXACT [] xref: Wikipedia:RNA-induced_silencing_complex is_a: GO:0031332 ! RNAi effector complex [Term] id: GO:0016443 name: bidentate ribonuclease III activity namespace: molecular_function def: "Catalysis of the digestion of double-stranded RNAs into 20 to 30-nucleotide products. These products typically associate to the RNA-induced silencing complex and serve as guide RNAs for posttranslational RNA interference." [PMID:15242644] synonym: "bidentate RNase III activity" EXACT [] xref: EC:3.1.26 is_a: GO:0004525 ! ribonuclease III activity [Term] id: GO:0016444 name: somatic cell DNA recombination namespace: biological_process def: "Recombination occurring within or between DNA molecules in somatic cells." [GOC:ma] is_a: GO:0006310 ! DNA recombination [Term] id: GO:0016445 name: somatic diversification of immunoglobulins namespace: biological_process def: "The somatic process that results in the generation of sequence diversity of immunoglobulins." [GOC:add, GOC:ma, ISBN:0781735149] synonym: "somatic diversification of antibodies" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0016446 name: somatic hypermutation of immunoglobulin genes namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins." [GOC:add, ISBN:0781735149, PMID:11205330, PMID:11205333, PMID:14975236, PMID:7813007] synonym: "somatic hypermutation of antibody genes" EXACT [] is_a: GO:0002566 ! somatic diversification of immune receptors via somatic mutation is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016447 name: somatic recombination of immunoglobulin gene segments namespace: biological_process def: "The process in which immunoglobulin genes are formed through recombination of the germline genetic elements, as known as immunoglobulin gene segments, within a single locus." [GOC:add, ISBN:0781735149] synonym: "somatic recombination of antibody gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0016453 name: C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a carbon atom on the acceptor molecule." [GOC:ai] is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0016454 name: C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a carbon atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 is_a: GO:0016408 ! C-acyltransferase activity is_a: GO:0016409 ! palmitoyltransferase activity [Term] id: GO:0016456 name: X chromosome located dosage compensation complex, transcription activating namespace: cellular_component def: "An RNA-protein complex localized to the X chromosome of males where it is required for the hyper-transcriptional activation of the X chromosome. An example of this is found in Drosophila melanogaster." [GOC:ma, GOC:mr, GOC:mtg_sensu, https://en.wikipedia.org/wiki/XY_sex-determination_system, PMID:20622855] synonym: "dosage compensation complex" BROAD [] is_a: GO:0046536 ! dosage compensation complex is_a: GO:1990904 ! ribonucleoprotein complex relationship: part_of GO:0000805 ! X chromosome [Term] id: GO:0016457 name: dosage compensation complex assembly involved in dosage compensation by hyperactivation of X chromosome namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the complex that mediates dosage compensation on the X chromosome of the heterogametic sex, ultimately resulting in a two-fold increase in transcription from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl] synonym: "dosage compensation complex assembly during dosage compensation by hyperactivation of X chromosome" RELATED [GOC:dph, GOC:tb] is_a: GO:0042714 ! dosage compensation complex assembly is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0009047 ! dosage compensation by hyperactivation of X chromosome [Term] id: GO:0016458 name: gene silencing namespace: biological_process def: "Any process carried out at the cellular level that results in either long-term transcriptional repression via action on chromatin structure or RNA mediated, post-transcriptional repression of gene expression." [GOC:dos, GOC:dph, GOC:jid, GOC:tb] comment: This is a rather broad grouping term. While it was originally defined for long-term, heritable, epigenetic effects, short term effects on expression mediated by RNA are also frequently referred to as gene silencing, and are grouped under this class. subset: goslim_pir synonym: "long-term maintenance of gene inactivation" NARROW [] xref: Wikipedia:Gene_silencing is_a: GO:0009987 ! cellular process is_a: GO:0010629 ! negative regulation of gene expression [Term] id: GO:0016459 name: myosin complex namespace: cellular_component def: "A protein complex, formed of one or more myosin heavy chains plus associated light chains and other proteins, that functions as a molecular motor; uses the energy of ATP hydrolysis to move actin filaments or to move vesicles or other cargo on fixed actin filaments; has magnesium-ATPase activity and binds actin. Myosin classes are distinguished based on sequence features of the motor, or head, domain, but also have distinct tail regions that are believed to bind specific cargoes." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0016460 name: myosin II complex namespace: cellular_component def: "A myosin complex containing two class II myosin heavy chains, two myosin essential light chains and two myosin regulatory light chains. Also known as classical myosin or conventional myosin, the myosin II class includes the major muscle myosin of vertebrate and invertebrate muscle, and is characterized by alpha-helical coiled coil tails that self assemble to form a variety of filament structures." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, ISBN:96235764] synonym: "conventional myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016461 name: unconventional myosin complex namespace: cellular_component alt_id: GO:0005860 def: "A portmanteau term for myosins other than myosin II." [GOC:ma] comment: Note that this term is retained because it is widely used by biologists. synonym: "non-muscle myosin" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0016462 name: pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a pyrophosphate bond between two phosphate groups, leaving one phosphate on each of the two fragments." [EC:3.6.1.-, GOC:curators] xref: EC:3.6.1 xref: reactome:R-HSA-6810472 "NUDT13 hydrolyses AP6A to AP4 and ADP" is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0016463 name: zinc-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Zn2+(in) -> ADP + phosphate + Zn2+(out)." [EC:3.6.3.5] synonym: "AtHMA4" RELATED [EC:3.6.3.5] synonym: "ATP phosphohydrolase (Zn2+-exporting)" EXACT [EC:3.6.3.5] synonym: "P(1B)-type ATPase activity" NARROW [EC:3.6.3.5] synonym: "P1B-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "zinc exporting ATPase activity" EXACT [] synonym: "zinc-translocating P-type ATPase activity" BROAD [EC:3.6.3.5] synonym: "Zn(2+)-exporting ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn(II)-translocating P-type ATPase activity" EXACT [EC:3.6.3.5] synonym: "Zn2+-exporting ATPase activity" EXACT [EC:3.6.3.5] xref: EC:3.6.3.5 xref: MetaCyc:3.6.3.5-RXN xref: RHEA:20621 is_a: GO:0005385 ! zinc ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0016464 name: chloroplast protein-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the chloroplast stroma." [EC:3.6.3.52] synonym: "ATP phosphohydrolase (chloroplast protein-importing)" EXACT [EC:3.6.3.52] synonym: "chloroplast protein ABC transporter" NARROW [] xref: EC:3.6.3.52 xref: MetaCyc:3.6.3.52-RXN is_a: GO:0015462 ! ATPase-coupled protein transmembrane transporter activity [Term] id: GO:0016465 name: chaperonin ATPase complex namespace: cellular_component def: "Multisubunit protein complex with 2x7 (Type I, in most cells) or 2x8 (Type II, in Archaea) ATP-binding sites involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9] is_a: GO:0044445 ! cytosolic part is_a: GO:0101031 ! chaperone complex [Term] id: GO:0016466 name: obsolete hydrogen-translocating A-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in archae." [TC:3.A.2.3.1] comment: This term was made obsolete because it represents a gene product. synonym: "hydrogen-translocating A-type ATPase activity" EXACT [] synonym: "proton-translocating A-type ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0016467 name: obsolete hydrogen-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.1, TC:3.A.2.1.3] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] synonym: "F1-ATPase activity" EXACT [] synonym: "hydrogen-translocating F-type ATPase activity" EXACT [] synonym: "proton-translocating F-type ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0016468 name: obsolete sodium-translocating F-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in eukaryotic mitochondria and chloroplasts and in bacteria." [TC:3.A.2.1.2] comment: This term was made obsolete because it represents a gene product. synonym: "ATP synthase" BROAD [] synonym: "sodium-translocating F-type ATPase activity" EXACT [] is_obsolete: true consider: GO:0046932 consider: GO:0046962 [Term] id: GO:0016469 name: proton-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of protons across a membrane. The complex comprises a membrane sector (F0, V0, or A0) that carries out proton transport and a cytoplasmic compartment sector (F1, V1, or A1) that catalyzes ATP synthesis or hydrolysis. Two major types have been characterized: V-type ATPases couple ATP hydrolysis to the transport of protons across a concentration gradient, whereas F-type ATPases, also known as ATP synthases, normally run in the reverse direction to utilize energy from a proton concentration or electrochemical gradient to synthesize ATP. A third type, A-type ATPases have been found in archaea, and are closely related to eukaryotic V-type ATPases but are reversible." [GOC:mah, ISBN:0716743663, PMID:16691483] subset: goslim_metagenomics subset: goslim_pir synonym: "hydrogen-transporting two-sector ATPase complex" EXACT [] synonym: "vacuolar hydrogen-transporting ATPase" RELATED [] is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0016471 name: vacuolar proton-transporting V-type ATPase complex namespace: cellular_component def: "A proton-transporting two-sector ATPase complex found in the vacuolar membrane, where it acts as a proton pump to mediate acidification of the vacuolar lumen." [GOC:mah, ISBN:0716743663, PMID:16449553] comment: See also the cellular component terms 'vacuolar proton-transporting V-type ATPase, V1 domain ; GO:0000221' and 'vacuolar proton-transporting V-type ATPase, V0 domain ; GO:0000220' and the molecular function term 'hydrogen ion transporting ATPase activity, rotational mechanism ; GO:0046961'. synonym: "vacuolar hydrogen-translocating V-type ATPase complex" EXACT [] is_a: GO:0033176 ! proton-transporting V-type ATPase complex is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0016472 name: sodium ion-transporting two-sector ATPase complex namespace: cellular_component def: "A large protein complex that catalyzes the synthesis or hydrolysis of ATP by a rotational mechanism, coupled to the transport of sodium ions across a membrane. The complex comprises a membrane sector (F0 or V0) that carries out ion transport and a cytoplasmic compartment sector (F1 or V1) that catalyzes ATP synthesis or hydrolysis." [GOC:mah, PMID:14656431] subset: goslim_pir synonym: "sodium-transporting two-sector ATPase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0016473 name: sodium ion-transporting F-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism." [GOC:mah, PMID:14656431] synonym: "sodium-translocating F-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016474 name: sodium ion-transporting V-type ATPase complex namespace: cellular_component def: "A sodium ion-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of sodium ions across a concentration gradient. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis." [GOC:mah, PMID:15802565] synonym: "sodium-translocating V-type ATPase complex" EXACT [] is_a: GO:0016472 ! sodium ion-transporting two-sector ATPase complex [Term] id: GO:0016475 name: detection of nuclear:cytoplasmic ratio namespace: biological_process def: "The process in which the size of the nucleus with respect to its cytoplasm is sensed by a cell." [GOC:jl] synonym: "interpretation of nuclear:cytoplasmic ratio" EXACT [] synonym: "sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0016049 ! cell growth [Term] id: GO:0016476 name: regulation of embryonic cell shape namespace: biological_process def: "Any process that modulates the surface configuration of an embryonic cell." [GOC:dph, GOC:tb] synonym: "shape changes of embryonic cells" RELATED [GOC:dph, GOC:tb] is_a: GO:0008360 ! regulation of cell shape is_a: GO:0045995 ! regulation of embryonic development [Term] id: GO:0016477 name: cell migration namespace: biological_process def: "The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms." [GOC:cjm, GOC:dph, GOC:ems, GOC:pf, http://en.wikipedia.org/wiki/Cell_migration] xref: Wikipedia:Cell_migration is_a: GO:0048870 ! cell motility [Term] id: GO:0016479 name: negative regulation of transcription by RNA polymerase I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase I." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase I promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase I promoter" NARROW [] synonym: "negative regulation of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase I promoter" EXACT [] is_a: GO:0006356 ! regulation of transcription by RNA polymerase I is_a: GO:0045892 ! negative regulation of transcription, DNA-templated relationship: negatively_regulates GO:0006360 ! transcription by RNA polymerase I [Term] id: GO:0016480 name: negative regulation of transcription by RNA polymerase III namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription mediated by RNA polymerase III." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase III promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase III promoter" NARROW [] synonym: "negative regulation of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from RNA polymerase III promoter" EXACT [] is_a: GO:0006359 ! regulation of transcription by RNA polymerase III is_a: GO:0045892 ! negative regulation of transcription, DNA-templated relationship: negatively_regulates GO:0006383 ! transcription by RNA polymerase III [Term] id: GO:0016482 name: cytosolic transport namespace: biological_process def: "The directed movement of substances or organelles within the cytosol." [GOC:ai] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0016483 name: tryptophan hydroxylase activator activity namespace: molecular_function def: "Increases the activity of the enzyme tryptophase hydroxylase." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0016484 name: obsolete proprotein convertase 2 activator activity namespace: molecular_function def: "OBSOLETE. Required for the maturation and activation of proprotein convertase 2." [GOC:ma, PMID:10749852] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "proprotein convertase 2 activator activity" EXACT [] is_obsolete: true consider: GO:0016504 [Term] id: GO:0016485 name: protein processing namespace: biological_process alt_id: GO:0051605 def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a protein. Protein maturation is the process leading to the attainment of the full functional capacity of a protein." [GOC:curators, GOC:jl, GOC:jsg] subset: goslim_chembl synonym: "peptidolysis during protein maturation" RELATED [GOC:mah] synonym: "protein maturation by peptide bond cleavage" EXACT [GOC:bf] synonym: "protein maturation by peptide bond hydrolysis" EXACT [GOC:mah] synonym: "protein maturation by proteolysis" RELATED [GOC:mah] is_a: GO:0006508 ! proteolysis is_a: GO:0051604 ! protein maturation [Term] id: GO:0016486 name: peptide hormone processing namespace: biological_process def: "The generation of a mature peptide hormone by posttranslational processing of a prohormone." [GOC:mah] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016485 ! protein processing is_a: GO:0042445 ! hormone metabolic process [Term] id: GO:0016487 name: farnesol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] synonym: "farnesol metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0016093 ! polyprenol metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034308 ! primary alcohol metabolic process [Term] id: GO:0016488 name: farnesol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [GOC:go_curators] synonym: "farnesol breakdown" EXACT [] synonym: "farnesol catabolism" EXACT [] synonym: "farnesol degradation" EXACT [] is_a: GO:0016095 ! polyprenol catabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0034310 ! primary alcohol catabolic process [Term] id: GO:0016490 name: structural constituent of peritrophic membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the peritrophic membrane, a tubular sheath of cuticle that shields the epithelial cells of the midgut from the gut contents. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "structural constituent of peritrophic matrix" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0016491 name: oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced." [GOC:go_curators] comment: Note that enzymes of class EC:1.97.-.- should also be annotated to this term. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "oxidoreductase activity, acting on other substrates" NARROW [] synonym: "redox activity" EXACT [] xref: EC:1 xref: reactome:R-HSA-1614362 "SUMF1 mediates the oxidation of cysteine to formylglycine, producing active arylsulfatases" xref: reactome:R-HSA-209921 "Monoiodinated tyrosine can be deiodinated" xref: reactome:R-HSA-209960 "Diiodinated tyrosine can be deiodinated" xref: reactome:R-HSA-3095889 "MMACHC reduces Cbl" xref: reactome:R-HSA-390425 "FAR1 reduces PalmCoA to HXOL" xref: reactome:R-HSA-390438 "FAR2 reduces PalmCoA to HXOL" xref: reactome:R-HSA-5662660 "Dopachrome is transformed to DHICA by DCT" xref: reactome:R-HSA-8878581 "TYRP1 oxidises DHICA to IQCA" xref: reactome:R-HSA-8936442 "MARC1,MARC2 reduce N-hydroxylated compounds" xref: reactome:R-HSA-9020249 "Hydroperoxy reductase reduces 4(S)-Hp-17(S)-HDHA to RvD6" xref: reactome:R-HSA-9020260 "Hydroperoxy reducatse reduces 7(S)-Hp-17(S)-HDHA to RvD5" xref: reactome:R-HSA-9024624 "Hydroperoxy reductase reduces 4(S)-Hp-17(R)-HDHA to AT-RvD6" xref: reactome:R-HSA-9024630 "Hydroperoxy reductase reduces 7(S)-Hp-17(R)-HDHA to AT-RvD5" xref: reactome:R-HSA-9025007 "Hydroperoxy reductase reduces 7(S),14(S)-diHp-DHA to 7-epi-MaR1" xref: reactome:R-HSA-9026001 "Hydroperoxy reductase reduces 7,17-diHp-DPAn-3 to RvD5n-3DPA" xref: reactome:R-HSA-9026917 "Lipoxygenase dehydrogenates 7(S),17(S)-diHp-DHA to 7S(8)-epoxy-17(S)-HDHA" xref: reactome:R-HSA-9027033 "Hydroperoxy reducatase reduces 14(S)-Hp-DHA to 14(S)-HDHA" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016492 name: G protein-coupled neurotensin receptor activity namespace: molecular_function def: "Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [PMID:10390649] synonym: "G protein coupled neurotensin receptor activity" EXACT [] synonym: "G-protein coupled neurotensin receptor activity" EXACT [] synonym: "neurotensin receptor activity, G protein coupled" EXACT [] synonym: "neurotensin receptor activity, G-protein coupled" EXACT [GOC:bf] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0016493 name: C-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:signaling, PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity [Term] id: GO:0016494 name: C-X-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X-C chemokine has a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:signaling, PMID:8662823] is_a: GO:0004950 ! chemokine receptor activity [Term] id: GO:0016495 name: C-X3-C chemokine receptor activity namespace: molecular_function def: "Combining with a C-X3-C chemokine and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A C-X3-C chemokine has three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:dph, GOC:signaling] is_a: GO:0004950 ! chemokine receptor activity [Term] id: GO:0016496 name: substance P receptor activity namespace: molecular_function def: "Combining with substance P, the peptide Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016497 name: substance K receptor activity namespace: molecular_function def: "Combining with substance K, the peptide His-Lys-Thr-Asp-Ser-Phe-Val-Gly-Leu-Met, to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] synonym: "neurokinin A receptor activity" EXACT [] synonym: "neuromedin L receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016498 name: neuromedin K receptor activity namespace: molecular_function def: "Combining with neuromedin K, the peptide Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] synonym: "neurokinin B receptor activity" EXACT [] is_a: GO:0004995 ! tachykinin receptor activity [Term] id: GO:0016499 name: orexin receptor activity namespace: molecular_function def: "Combining with orexin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! G protein-coupled peptide receptor activity [Term] id: GO:0016500 name: protein-hormone receptor activity namespace: molecular_function def: "Combining with a protein hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0016501 name: prostacyclin receptor activity namespace: molecular_function alt_id: GO:0004959 def: "Combining with prostacyclin (PGI(2)) to initiate a change in cell activity." [ISBN:0198506732] synonym: "PGI receptor activity" RELATED [] synonym: "PGI(2) receptor activity" EXACT [] synonym: "prostaglandin I receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0016502 name: nucleotide receptor activity namespace: molecular_function def: "Combining with a nucleotide and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. A nucleotide is a compound that consists of a nucleoside esterified with a phosphate molecule." [GOC:signaling, ISBN:0198506732] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0016503 name: pheromone receptor activity namespace: molecular_function def: "Combining with a pheromone to initiate a change in cell activity. A pheromone is a substance used in olfactory communication between organisms of the same species eliciting a change in sexual or social behavior." [CHEBI:26013, GOC:hjd, ISBN:0198506732] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0016504 name: peptidase activator activity namespace: molecular_function def: "Binds to and increases the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:ai] synonym: "protease activator activity" NARROW [GOC:mah] xref: reactome:R-HSA-168865 "NA activation of TGF-beta" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0061134 ! peptidase regulator activity [Term] id: GO:0016505 name: peptidase activator activity involved in apoptotic process namespace: molecular_function def: "Increases the activity of a peptidase that is involved in the apoptotic process." [GOC:BHF, GOC:mah, GOC:mtg_apoptosis, GOC:rl] synonym: "apoptotic protease activator activity" NARROW [] is_a: GO:0016504 ! peptidase activator activity [Term] id: GO:0016506 name: obsolete apoptosis activator activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly activate any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "apoptosis activator activity" EXACT [] is_obsolete: true replaced_by: GO:0006915 [Term] id: GO:0016507 name: mitochondrial fatty acid beta-oxidation multienzyme complex namespace: cellular_component def: "A complex that includes the long-chain 3-hydroxyacyl-CoA dehydrogenase and long-chain enoyl-CoA hydratase activities in two subunits (alpha and beta), catalyzing two steps of the fatty acid beta-oxidation cycle within the mitochondrial matrix." [GOC:ma] synonym: "fatty acid beta-oxidation multienzyme complex" BROAD [GOC:imk] synonym: "trifunctional enzyme" RELATED [] is_a: GO:0036125 ! fatty acid beta-oxidation multienzyme complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0016508 name: long-chain-enoyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain (3S)-3-hydroxyacyl-CoA = a long-chain trans-2-enoyl-CoA + H2O. A long-chain acyl-CoA is an acyl-CoA thioester where the acyl chain contains 13 to 22 carbon atoms." [EC:4.2.1.74] synonym: "long-chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.74] synonym: "long-chain-(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.74] xref: EC:4.2.1.74 xref: MetaCyc:LONG-CHAIN-ENOYL-COA-HYDRATASE-RXN xref: reactome:R-HSA-2066778 "Hydration of delta2-tetracosaheptaenoyl-CoA to 3-hydroxy tetracosahexaenoyl-CoA" xref: reactome:R-HSA-2066780 "Dehydrogenation of 3-hydroxy tetracosahexaenoyl-CoA" xref: reactome:R-HSA-389986 "trans-2,3-dehydropristanoyl-CoA + H2O => 3-hydroxypristanoyl-CoA" xref: reactome:R-HSA-390252 "HSD17B4 hydrates trans-2,3-dehydrohexacosanoyl-CoA" xref: reactome:R-HSA-6809263 "EHHADH hydrates trans-2,3-dehydrohexacosanoyl-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0016509 name: long-chain-3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD(P)+ = 3-oxoacyl-CoA + NAD(P)H + H+, where the acyl group is a long-chain fatty acid residue. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22." [CHEBI:15904, EC:1.1.1.211, GOC:pde] comment: Also see '3-hydroxyacyl-CoA dehydrogenase activity ; GO:0003857'. synonym: "beta-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "LCHAD" RELATED [EC:1.1.1.211] synonym: "long-chain 3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.211] synonym: "long-chain-(S)-3-hydroxyacyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.211] xref: EC:1.1.1.211 xref: MetaCyc:1.1.1.211-RXN xref: reactome:R-HSA-548818 "HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA" is_a: GO:0003857 ! 3-hydroxyacyl-CoA dehydrogenase activity [Term] id: GO:0016511 name: obsolete endothelin-converting enzyme activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "endothelin-converting enzyme activity" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016512 name: obsolete endothelin-converting enzyme 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of endothelin 1 by cleavage of the Trp21-Val22 bond in the precursor." [EC:3.4.24.71] comment: This term was made obsolete because it represents a gene product. synonym: "ECE-1 activity" EXACT [EC:3.4.24.71] synonym: "endothelin-converting enzyme 1 activity" EXACT [] xref: EC:3.4.24.71 xref: MetaCyc:3.4.24.71-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016513 name: core-binding factor complex namespace: cellular_component def: "A heterodimeric transcription factor complex that contains an alpha subunit (Runx1, Runx2 or Runx3 in human) that binds DNA and a non-DNA-binding beta subunit (CBFbeta), and binds to a consensus sequence 5'-YGYGGTY-3' found in several enhancers and promoters; the beta subunit enhances the DNA binding of the alpha subunit." [PMID:15156179, PMID:8497254] synonym: "AML1 complex" NARROW [] synonym: "CBF complex" EXACT [] synonym: "PEPB2 complex" NARROW [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0016514 name: SWI/SNF complex namespace: cellular_component def: "A SWI/SNF-type complex that contains 8 to 14 proteins, including both conserved (core) and nonconserved components; contains the ATPase product of the yeast SNF2 or mammalian SMARCA4/BAF190A/BRG1 gene, or an ortholog thereof." [GOC:bhm, PMID:12672490] synonym: "SWI-SNF complex" EXACT [GOC:mah] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0016515 name: interleukin-13 receptor activity namespace: molecular_function def: "Combining with interleukin-13 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-13 receptor activity" EXACT [GOC:mah] synonym: "IL-13R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0016516 name: interleukin-4 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-4 (IL-4) and consists of an alpha chain that binds IL-4 with high affinity and a gamma common chain that also forms part of the interleukin-2 receptor." [PMID:10358772] synonym: "IL-4 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0016517 name: interleukin-12 receptor activity namespace: molecular_function def: "Combining with interleukin-12 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-12 receptor activity" EXACT [GOC:mah] synonym: "IL-12R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0016518 name: interleukin-14 receptor activity namespace: molecular_function def: "Combining with interleukin-14 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling] synonym: "IL-14 receptor activity" EXACT [GOC:mah] synonym: "IL-14R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0016519 name: gastric inhibitory peptide receptor activity namespace: molecular_function def: "Combining with gastric inhibitory peptide (GIP) and transmitting the signal across the membrane to activate an associated G-protein." [GOC:mah, PMID:8243312] synonym: "GIP receptor activity" EXACT [PMID:19251046] synonym: "glucose-dependent insulinotropic polypeptide receptor activity" EXACT [PMID:19251046] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0016520 name: growth hormone-releasing hormone receptor activity namespace: molecular_function def: "Combining with growth hormone-releasing hormone to initiate a change in cell activity." [PMID:12529933] is_a: GO:0004930 ! G protein-coupled receptor activity [Term] id: GO:0016521 name: pituitary adenylate cyclase activating polypeptide activity namespace: molecular_function def: "The action characteristic of pituitary adenylate cyclase activating polypeptide, a peptide produced in the hypothalamus that binds to receptors to exert pleiotropic effects including control of neurotransmitter release, vasodilation, bronchodilation, activation of intestinal motility, increase in insulin and histamine secretion, immune modulation, and stimulation of cell proliferation and differentiation." [GOC:mah, PMID:19805477] synonym: "pituitary adenylyl cyclase activating polypeptide activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016524 name: latrotoxin receptor activity namespace: molecular_function def: "Combining with alpha-latrotoxin, a potent presynaptic neurotoxin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:jl, GOC:signaling, PMID:10025961] synonym: "latrophilin" NARROW [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0016525 name: negative regulation of angiogenesis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis." [GOC:go_curators] synonym: "down regulation of angiogenesis" EXACT [] synonym: "down-regulation of angiogenesis" EXACT [] synonym: "downregulation of angiogenesis" EXACT [] synonym: "inhibition of angiogenesis" NARROW [] is_a: GO:0045765 ! regulation of angiogenesis is_a: GO:2000181 ! negative regulation of blood vessel morphogenesis relationship: negatively_regulates GO:0001525 ! angiogenesis [Term] id: GO:0016527 name: obsolete brain-specific angiogenesis inhibitor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it is based on anatomical information, and describes at least one gene product. It has also never been defined. synonym: "brain-specific angiogenesis inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004930 [Term] id: GO:0016528 name: sarcoplasm namespace: cellular_component def: "The cytoplasm of a muscle cell; includes the sarcoplasmic reticulum." [ISBN:0198547684] xref: Wikipedia:Sarcoplasm is_a: GO:0005737 ! cytoplasm [Term] id: GO:0016529 name: sarcoplasmic reticulum namespace: cellular_component alt_id: GO:0008221 def: "A fine reticular network of membrane-limited elements that pervades the sarcoplasm of a muscle cell; continuous over large portions of the cell and with the nuclear envelope; that part of the endoplasmic reticulum specialized for calcium release, uptake and storage." [GOC:mtg_muscle, ISBN:0124325653, ISBN:0198547684] comment: See also the cellular component terms 'sarcoplasm ; GO:0016528', 'nuclear envelope ; GO:0005635' and 'endoplasmic reticulum ; GO:0005783'. xref: Wikipedia:Endoplasmic_reticulum#Sarcoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0016530 name: metallochaperone activity namespace: molecular_function def: "Directly binding to and delivering metal ions to a target protein." [PMID:11739376] subset: goslim_pir is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0016531 name: copper chaperone activity namespace: molecular_function def: "Directly binding to and delivering copper ions to a target protein." [PMID:10790544, PMID:11739376] is_a: GO:0005507 ! copper ion binding is_a: GO:0016530 ! metallochaperone activity [Term] id: GO:0016532 name: superoxide dismutase copper chaperone activity namespace: molecular_function def: "A copper chaperone activity that specifically delivers copper to the Cu-Zn superoxide dismutase, to activate superoxide dismutase activity." [GOC:vw, http://link.springer-ny.com/link/service/journals/00335/papers/0011005/00110409.html, PMID:15064408, PMID:9295278] comment: See also the molecular function term 'superoxide dismutase activity ; GO:0004784'. is_a: GO:0008047 ! enzyme activator activity is_a: GO:0016531 ! copper chaperone activity [Term] id: GO:0016533 name: protein kinase 5 complex namespace: cellular_component def: "A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent." [PMID:15689152] synonym: "cyclin-dependent protein kinase 5 holoenzyme complex" RELATED [] is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0016536 name: obsolete cyclin-dependent protein kinase 5 activator regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of cyclin-dependent protein kinase 5 activator." [GOC:ai] comment: This term was made obsolete because it refers to a specific gene product. synonym: "cyclin-dependent protein kinase 5 activator regulator activity" EXACT [] synonym: "cyclin-dependent protein kinase 5 activator, intrinsic regulator activity" NARROW [] is_obsolete: true [Term] id: GO:0016538 name: cyclin-dependent protein serine/threonine kinase regulator activity namespace: molecular_function alt_id: GO:0003751 alt_id: GO:0003752 alt_id: GO:0003753 def: "Modulates the activity of a cyclin-dependent protein serine/threonine kinase, enzymes of the protein kinase family that are regulated through association with cyclins and other proteins." [GOC:pr, GOC:rn, PMID:7877684, PMID:9442875] synonym: "cyclin" BROAD [] synonym: "cyclin-dependent protein kinase regulator activity" BROAD [] synonym: "cyclin-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "G1/S-specific cyclin" NARROW [] synonym: "G2/M-specific cyclin" NARROW [] xref: EC:2.7.1 xref: reactome:R-HSA-3215385 "CDK4 in CCND1:CDK4:PRMT5:WDR77 phosphorylates WDR77" is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0016539 name: intein-mediated protein splicing namespace: biological_process def: "The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues." [GOC:ma, http://www.neb.com/neb/inteins.html] synonym: "intein" RELATED [] is_a: GO:0030908 ! protein splicing [Term] id: GO:0016540 name: protein autoprocessing namespace: biological_process def: "Processing which a protein carries out itself. This involves actions such as the autolytic removal of residues to generate the mature form of the protein." [GOC:ai, PMID:9335337] subset: goslim_chembl is_a: GO:0016485 ! protein processing [Term] id: GO:0016541 name: obsolete intein namespace: molecular_function def: "OBSOLETE. Intervening protein sequence excised from a protein precursor in protein splicing; inteins catalyze their own excision and many also possess endonuclease activity." [GOC:mah, http://www.neb.com/neb/inteins.html, PMID:8165123] comment: This term was made obsolete because it refers to a protein sequence feature. synonym: "intein" EXACT [] is_obsolete: true consider: GO:0004519 consider: GO:0016539 [Term] id: GO:0016543 name: male courtship behavior, orientation prior to leg tapping and wing vibration namespace: biological_process def: "The process during courtship, where the male orients towards a potential partner. An example of this is found in Drosophila melanogaster." [GOC:sensu, PMID:11092827] synonym: "male courtship behavior, orientation" RELATED [] synonym: "male courtship behaviour, orientation" RELATED [] synonym: "male courtship behaviour, orientation prior to leg tapping and wing vibration" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016544 name: male courtship behavior, tapping to detect pheromone namespace: biological_process def: "The process during courtship where the male insect taps the female with his frontal leg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, tapping" RELATED [] synonym: "male courtship behaviour, tapping" EXACT [] synonym: "male courtship behaviour, tapping to detect pheromone" RELATED [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016545 name: male courtship behavior, veined wing vibration namespace: biological_process def: "The process during courtship where the male insect vibrates his wings. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, wing vibration" RELATED [] synonym: "male courtship behaviour, veined wing vibration" EXACT [] synonym: "male courtship behaviour, wing vibration" RELATED [] is_a: GO:0048065 ! male courtship behavior, veined wing extension [Term] id: GO:0016546 name: male courtship behavior, proboscis-mediated licking namespace: biological_process def: "The process during courtship where the male fly licks the genitalia of a stationary female fly with his proboscis. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11092827] synonym: "male courtship behavior, licking" RELATED [] synonym: "male courtship behaviour, licking" RELATED [] synonym: "male courtship behaviour, proboscis-mediated licking" EXACT [] is_a: GO:0008049 ! male courtship behavior [Term] id: GO:0016550 name: obsolete insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during or after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "insertion or deletion editing" EXACT [] synonym: "insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016551 name: obsolete posttranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place after transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "posttranscriptional insertion or deletion editing" EXACT [] synonym: "posttranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016552 name: obsolete cotranscriptional insertion or deletion editing namespace: biological_process def: "OBSOLETE. The insertion into or deletion from an RNA molecule of nucleotide residues not encoded in DNA; takes place during transcription." [PMID:11092837] comment: This term was made obsolete because it represents two separate processes (insertion and deletion). synonym: "cotranscriptional insertion or deletion editing" EXACT [] synonym: "cotranscriptional insertion/deletion editing" EXACT [] is_obsolete: true consider: GO:0070705 consider: GO:0070706 [Term] id: GO:0016553 name: base conversion or substitution editing namespace: biological_process def: "Any base modification or substitution events that result in alterations in the coding potential or structural properties of RNAs as a result of changes in the base-pairing properties of the modified ribonucleoside(s)." [PMID:11092837] synonym: "base conversion/substitution editing" EXACT [] is_a: GO:0009451 ! RNA modification [Term] id: GO:0016554 name: cytidine to uridine editing namespace: biological_process def: "The conversion of a cytosine residue to uridine in an RNA molecule by deamination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016555 name: uridine to cytidine editing namespace: biological_process def: "The conversion of a uridine residue to cytosine in an RNA molecule by amination." [PMID:11092837] is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0016556 name: mRNA modification namespace: biological_process alt_id: GO:0006381 def: "The covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. synonym: "mRNA editing" NARROW [GOC:dph, GOC:hjd, GOC:tb] is_a: GO:0009451 ! RNA modification is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0016557 name: peroxisome membrane biogenesis namespace: biological_process def: "The process in which a peroxisome membrane is synthesized, aggregates, and bonds together." [GOC:mah] is_a: GO:0044091 ! membrane biogenesis relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016558 name: protein import into peroxisome matrix namespace: biological_process def: "The import of proteins into the peroxisomal matrix. A peroxisome targeting signal (PTS) binds to a soluble receptor protein in the cytosol, and the resulting complex then binds to a receptor protein in the peroxisome membrane and is imported. The cargo protein is then released into the peroxisome matrix." [ISBN:0716731363, PMID:11687502, PMID:11988772] synonym: "peroxisome matrix protein import" EXACT [] synonym: "protein transport to peroxisome matrix" EXACT [] is_a: GO:0006625 ! protein targeting to peroxisome is_a: GO:0015919 ! peroxisomal membrane transport is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0065002 ! intracellular protein transmembrane transport [Term] id: GO:0016559 name: peroxisome fission namespace: biological_process def: "The division of a mature peroxisome within a cell to form two or more separate peroxisome compartments." [GOC:mah, PMID:11687502, PMID:14754507] synonym: "peroxisome division" EXACT [] synonym: "peroxisome proliferation" EXACT [] is_a: GO:0048285 ! organelle fission relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0016560 name: protein import into peroxisome matrix, docking namespace: biological_process def: "The process in which a complex formed of a peroxisome targeting sequence (PTS) receptor bound to a PTS-bearing protein docks with translocation machinery in the peroxisomal membrane." [PMID:11687502, PMID:11988772, PMID:14754507] synonym: "peroxisome matrix protein import, docking" EXACT [] synonym: "peroxisome receptor docking" RELATED [] synonym: "protein docking during peroxisome matrix protein import" EXACT [] synonym: "protein docking during protein import into peroxisome matrix" EXACT [] synonym: "protein docking during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, docking" EXACT [] is_a: GO:0008104 ! protein localization relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016561 name: protein import into peroxisome matrix, translocation namespace: biological_process def: "The process in which proteins are moved across the peroxisomal membrane into the matrix. It is likely that the peroxisome targeting sequence receptor remains associated with cargo proteins during translocation." [PMID:11687502] synonym: "peroxisome matrix protein import, translocation" EXACT [] synonym: "peroxisome receptor translocation" RELATED [] synonym: "protein translocation during peroxisome matrix protein import" EXACT [] synonym: "protein translocation during protein import into peroxisome matrix" EXACT [] synonym: "protein translocation during protein transport into peroxisome matrix" EXACT [] synonym: "protein transport into peroxisome matrix, translocation" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016562 name: protein import into peroxisome matrix, receptor recycling namespace: biological_process def: "The process in which peroxisome targeting sequence receptors dissociates from cargo proteins and are returned to the cytosol." [PMID:11687502] synonym: "peroxisome matrix protein import, receptor recycling" EXACT [] synonym: "peroxisome receptor recycling" RELATED [] synonym: "protein transport into peroxisome matrix, receptor recycling" EXACT [] synonym: "PTS receptor recycling" RELATED [] synonym: "receptor recycling during peroxisome matrix protein import" EXACT [] synonym: "receptor recycling during protein import into peroxisome matrix" EXACT [] synonym: "receptor recycling during protein transport into peroxisome matrix" EXACT [] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0016558 ! protein import into peroxisome matrix [Term] id: GO:0016563 name: obsolete transcription activator activity namespace: molecular_function alt_id: GO:0003710 def: "OBSOLETE. Any transcription regulator activity required for initiation or upregulation of transcription." [GOC:jl, ISBN:0124325653] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription activating factor" NARROW [] synonym: "transcription activator activity" EXACT [] synonym: "transcriptional activator activity" EXACT [] is_obsolete: true replaced_by: GO:0001228 [Term] id: GO:0016564 name: obsolete transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates transcription." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "negative transcriptional regulator activity" EXACT [] synonym: "transcription repressor activity" EXACT [] synonym: "transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0001227 [Term] id: GO:0016565 name: obsolete general transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of genes globally, and is not specific to a particular gene or gene set." [GOC:mah] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "general transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0001141 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0016566 name: obsolete specific transcriptional repressor activity namespace: molecular_function def: "OBSOLETE. Any activity that stops or downregulates transcription of specific genes or sets of genes." [GOC:mah] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "specific transcriptional repressor activity" EXACT [] is_obsolete: true consider: GO:0001141 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0016567 name: protein ubiquitination namespace: biological_process def: "The process in which one or more ubiquitin groups are added to a protein." [GOC:ai] synonym: "protein ubiquitinylation" EXACT [] synonym: "protein ubiquitylation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016569 name: covalent chromatin modification namespace: biological_process def: "The alteration of DNA or protein in chromatin by the covalent addition or removal of chemical groups." [GOC:mah, GOC:vw] synonym: "chromatin modification" EXACT [] is_a: GO:0006325 ! chromatin organization is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0016570 name: histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein." [GOC:krc] subset: goslim_yeast xref: Wikipedia:Histone#Histone_modifications_in_chromatin_regulation is_a: GO:0006464 ! cellular protein modification process is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0016571 name: histone methylation namespace: biological_process def: "The modification of histones by addition of methyl groups." [GOC:ai] xref: Wikipedia:Histone_methylation is_a: GO:0006479 ! protein methylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016572 name: histone phosphorylation namespace: biological_process def: "The modification of histones by addition of phosphate groups." [GOC:ai] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016573 name: histone acetylation namespace: biological_process def: "The modification of a histone by the addition of an acetyl group." [GOC:ai] is_a: GO:0016570 ! histone modification is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0016574 name: histone ubiquitination namespace: biological_process def: "The modification of histones by addition of ubiquitin groups." [GOC:ai] synonym: "histone ubiquitinylation" EXACT [] synonym: "histone ubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination is_a: GO:0016570 ! histone modification [Term] id: GO:0016575 name: histone deacetylation namespace: biological_process def: "The modification of histones by removal of acetyl groups." [GOC:ai] is_a: GO:0006476 ! protein deacetylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016576 name: histone dephosphorylation namespace: biological_process def: "The modification of histones by removal of phosphate groups." [GOC:ai] is_a: GO:0006470 ! protein dephosphorylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016577 name: histone demethylation namespace: biological_process def: "The modification of histones by removal of methyl groups." [GOC:ai] is_a: GO:0006482 ! protein demethylation is_a: GO:0016570 ! histone modification [Term] id: GO:0016578 name: histone deubiquitination namespace: biological_process def: "The modification of histones by removal of ubiquitin groups." [GOC:ai] synonym: "histone deubiquitinylation" EXACT [] synonym: "histone deubiquitylation" EXACT [] is_a: GO:0016570 ! histone modification is_a: GO:0016579 ! protein deubiquitination [Term] id: GO:0016579 name: protein deubiquitination namespace: biological_process alt_id: GO:0006514 def: "The removal of one or more ubiquitin groups from a protein." [GOC:ai] synonym: "deubiquitination" EXACT [] synonym: "protein deubiquitinylation" EXACT [] synonym: "protein deubiquitylation" EXACT [] is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0016580 name: Sin3 complex namespace: cellular_component def: "A multiprotein complex that functions broadly in eukaryotic organisms as a transcriptional repressor of protein-coding genes, through the gene-specific deacetylation of histones. Amongst its subunits, the Sin3 complex contains Sin3-like proteins, and a number of core proteins that are shared with the NuRD complex (including histone deacetylases and histone binding proteins). The Sin3 complex does not directly bind DNA itself, but is targeted to specific genes through protein-protein interactions with DNA-binding proteins." [PMID:10589671, PMID:11743021, PMID:12865422] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0016581 name: NuRD complex namespace: cellular_component def: "An approximately 2 MDa multi-subunit complex that exhibits ATP-dependent chromatin remodeling activity in addition to histone deacetylase (HDAC) activity, and has been shown to establish transcriptional repression of a number of target genes in vertebrates, invertebrates and fungi. Amongst its subunits, the NuRD complex contains histone deacetylases, histone binding proteins and Mi-2-like proteins." [PMID:10589671, PMID:11743021, PMID:17289569] synonym: "Mi-2 complex" EXACT [] synonym: "NRD complex" EXACT [] synonym: "nucleosome remodeling and histone deacetylation complex" EXACT [] is_a: GO:0000118 ! histone deacetylase complex is_a: GO:0090545 ! CHD-type complex is_a: GO:0090568 ! nuclear transcriptional repressor complex [Term] id: GO:0016582 name: obsolete non-covalent chromatin modification namespace: biological_process def: "OBSOLETE. The alteration of DNA or protein in chromatin by the non-covalent addition or removal of chemical groups." [GOC:jl, GOC:vw] comment: This term was made obsolete because it was added in error; its usefulness is unclear. is_obsolete: true [Term] id: GO:0016583 name: obsolete nucleosome modeling namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it has been replaced by more specific terms. synonym: "nucleosome modeling" EXACT [] is_obsolete: true consider: GO:0006334 [Term] id: GO:0016584 name: nucleosome positioning namespace: biological_process def: "Ordering of successions of nucleosomes into regular arrays so that nucleosomes are positioned at defined distances from one another." [GOC:bf, PMID:11447119, PMID:8676389] synonym: "nucleosome spacing" EXACT [] is_a: GO:0031497 ! chromatin assembly is_a: GO:0034728 ! nucleosome organization [Term] id: GO:0016585 name: obsolete chromatin remodeling complex namespace: cellular_component alt_id: GO:0005679 def: "OBSOLETE: Any complex that mediates dynamic changes in eukaryotic chromatin." [GOC:mah] comment: This term was made obsolete because its definition no longer reflects and cannot be modified to be consistent with the current state of knowledge. synonym: "chromatin remodeling complex" EXACT [] synonym: "chromatin remodelling complex" EXACT [] synonym: "nucleosome remodeling complex" EXACT [] is_obsolete: true consider: GO:0006338 [Term] id: GO:0016586 name: RSC-type complex namespace: cellular_component alt_id: GO:0070604 def: "A SWI/SNF-type complex that contains a bromodomain containing-protein, such as yeast Rsc1 or Rsc4 or mammalian PB1/BAF180. The RSC complex is generally recruited to RNA polymerase III promoters and is specifically recruited to RNA polymerase II promoters by transcriptional activators and repressors; it is also involved in non-homologous end joining" [GOC:bhm, PMID:11937489, PMID:12672490, PMID:15870268, PMID:19355820, PMID:8980231] comment: Term name, synonym and definition discussed in https://github.com/geneontology/go-ontology/issues/14106 synonym: "PBAF complex" EXACT [] synonym: "Polybromo- and BAF containing complex" EXACT [CORUM:565] synonym: "SWI/SNF complex B" EXACT [CORUM:565] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0016587 name: Isw1 complex namespace: cellular_component def: "A protein complex that contains an Isw1 subunit from the ISWI-family of ATPases and acts to modify chromatin structure." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016589 name: NURF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2L in mammals), a NURF301 homolog (BPTF in humans), and additional subunits, though the composition of these additional subunits varies slightly with species. NURF is involved in regulation of transcription from TRNA polymerase II promoters." [GOC:bf, GOC:krc, PMID:10779516, PMID:11279013, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "nucleosome remodeling factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016590 name: ACF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals, Isw2 in S. cerevisiae), an ACF1 homolog, and generally no other subunits, though Xenopus is an exception with a third non-conserved subunit. ACF plays roles in regulation of RNA polymerase II transcription and in DNA replication and repair." [GOC:bf, GOC:krc, PMID:12192034, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "ATP-utilizing chromatin assembly and remodeling factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0016591 name: RNA polymerase II, holoenzyme namespace: cellular_component def: "A nuclear DNA-directed RNA polymerase complex containing an RNA polymerase II core enzyme as well as additional proteins and transcription factor complexes, that are capable of promoter recognition and transcription initiation from an RNA polymerase II promoter in vivo. These additional components may include general transcription factor complexes TFIIA, TFIID, TFIIE, TFIIF, or TFIIH, as well as Mediator, SWI/SNF, GCN5, or SRBs and confer the ability to recognize promoters." [GOC:jl, GOC:krc, PMID:16858867, Wikipedia:Rna_polymerase_ii] subset: goslim_pir synonym: "DNA-directed RNA polymerase II, holoenzyme" EXACT [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0016592 name: mediator complex namespace: cellular_component alt_id: GO:0000119 def: "A protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The mediator complex is required for activation of transcription of most protein-coding genes, but can also act as a transcriptional corepressor. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins." [PMID:11454195, PMID:16168358, PMID:17870225] synonym: "CDK8-containing TRAP/mediator complex" RELATED [] synonym: "L mediator complex" EXACT [] synonym: "Srb-mediator complex" EXACT [GOC:mah] synonym: "TRAP complex" NARROW [] xref: Wikipedia:Mediator_(coactivator) is_a: GO:0032991 ! protein-containing complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0016593 name: Cdc73/Paf1 complex namespace: cellular_component def: "A multiprotein complex that associates with RNA polymerase II and general RNA polymerase II transcription factor complexes and may be involved in both transcriptional initiation and elongation. In Saccharomyces the complex contains Paf1p, Cdc73p, Ctr9p, Rtf1p, and Leo1p." [PMID:11884586] synonym: "Paf1 complex" EXACT [GOC:cjk] synonym: "Paf1p complex" EXACT [GOC:cjk] is_a: GO:0008023 ! transcription elongation factor complex relationship: part_of GO:0016591 ! RNA polymerase II, holoenzyme [Term] id: GO:0016594 name: glycine binding namespace: molecular_function def: "Interacting selectively and non-covalently with glycine, aminoethanoic acid." [GOC:ai] synonym: "aminoacetic acid binding" EXACT [] synonym: "aminoethanoic acid binding" EXACT [] synonym: "Gly binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0016597 ! amino acid binding is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0043169 ! cation binding [Term] id: GO:0016595 name: glutamate binding namespace: molecular_function def: "Interacting selectively and non-covalently with glutamate, the anion of 2-aminopentanedioic acid." [GOC:ai] synonym: "glutamic acid binding" EXACT [] is_a: GO:0016597 ! amino acid binding [Term] id: GO:0016596 name: thienylcyclohexylpiperidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thienylcyclohexylpiperidine." [GOC:jl] synonym: "TCP binding" BROAD [] is_a: GO:0008144 ! drug binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0016597 name: amino acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino acid, organic acids containing one or more amino substituents." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0016598 name: protein arginylation namespace: biological_process alt_id: GO:0019130 def: "The conjugation of arginine to the N-terminal aspartate or glutamate of a protein; required for the degradation of the protein via the ubiquitin pathway." [PMID:17896865] synonym: "protein amino acid arginylation" EXACT [] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0006511 ! ubiquitin-dependent protein catabolic process [Term] id: GO:0016600 name: flotillin complex namespace: cellular_component def: "A protein complex that contains flotillin-1 and flotillin-2, and may contain associated proteins. Flotillins associate into membrane microdomains resembling caveolae." [PMID:17206938, PMID:17600709] comment: See also the cellular component term 'caveola ; GO:0005901'. is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005901 ! caveola [Term] id: GO:0016601 name: Rac protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rac family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rac mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0016602 name: CCAAT-binding factor complex namespace: cellular_component def: "A heteromeric transcription factor complex that binds to the CCAAT-box upstream of promoters; functions as both an activator and a repressor, depending on its interacting cofactors. Typically trimeric consisting of NFYA, NFYB and NFYC subunits. In Saccharomyces, it activates the transcription of genes in response to growth in a nonfermentable carbon source and consists of four known subunits: HAP2, HAP3, HAP4 and HAP5." [GOC:bhm, PMID:7828851] synonym: "CBF complex" RELATED [GOC:bhm] synonym: "NF-Y transcription factor complex" RELATED [GOC:bhm] synonym: "nuclear transcription factor Y complex" RELATED [GOC:bhm] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0016603 name: glutaminyl-peptide cyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutaminyl-peptide = 5-oxoprolyl-peptide + NH3." [EC:2.3.2.5] synonym: "glutaminyl cyclase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-transfer ribonucleate cyclotransferase activity" EXACT [EC:2.3.2.5] synonym: "glutaminyl-tRNA cyclotransferase activity" NARROW [EC:2.3.2.5] synonym: "L-glutaminyl-peptide gamma-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.5] xref: EC:2.3.2.5 xref: MetaCyc:GLUTAMINYL-PEPTIDE-CYCLOTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016604 name: nuclear body namespace: cellular_component def: "Extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:ma, PMID:10330182] xref: NIF_Subcellular:sao505137457 is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0016605 name: PML body namespace: cellular_component def: "A class of nuclear body; they react against SP100 auto-antibodies (PML, promyelocytic leukemia); cells typically contain 10-30 PML bodies per nucleus; alterations in the localization of PML bodies occurs after viral infection." [GOC:ma, PMID:10944585] synonym: "ND10" EXACT [] synonym: "nuclear dot" RELATED [] synonym: "PML NB" EXACT [] synonym: "PML nuclear body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016606 name: LYSP100-associated nuclear domain namespace: cellular_component def: "A nuclear body that is enriched in the lymphoid cell-specific protein LYSp100B; LANDs are globular, electron-dense structures and are morphologically distinct from the annular structures characteristic of PML bodies." [PMID:10921892, PMID:8695863] synonym: "LANDs" EXACT [PMID:8695863] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016607 name: nuclear speck namespace: cellular_component def: "A discrete extra-nucleolar subnuclear domain, 20-50 in number, in which splicing factors are seen to be localized by immunofluorescence microscopy." [http://www.cellnucleus.com/] synonym: "nuclear speckle" EXACT [] synonym: "nuclear speckles" EXACT [] synonym: "speckle domain" NARROW [] synonym: "speckle focus" RELATED [] synonym: "splicing speckle" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0016608 name: growth hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of growth hormone-releasing hormone, any of a family of peptide hormones that act on the anterior pituitary to stimulate the secretion of growth hormone and exert a trophic effect on the gland." [ISBN:0198506732] synonym: "GHRF activity" EXACT [ISBN:0198506732] synonym: "GHRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016610 name: nitrogenase complex namespace: cellular_component def: "An enzyme complex composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase is tetrameric with an alpha2-beta2 structure and nitrogenase reductase is a homodimer, and both are associated with metal ions, which differ between species. Both proteins are required for the enzyme activity of the complex, the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, MetaCyc:CPLX-186, MetaCyc:CPLX-525] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0016611 name: iron-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing an iron-iron cluster found in species such as the photosynthetic bacterium Rhodobacter capsulatus. It is composed of two main subunits, dinitrogenase and nitrogenase reductase. Dinitrogenase, the iron-iron containing subunit, has an alpha1-beta2 or alpha2-beta2 structure, and the nitrogenase reductase subunit is a homodimer. Functions in the catalysis of the formation of oxidized ferredoxin and ammonia from reduced ferredoxin and nitrogen." [EC:1.18.6.1, GOC:jl, PMID:11848850] comment: Note that it is not established whether the nitrogenase exists in vivo in a specific particle or whether the nitrogenase proteins are bound nonspecifically to the membranes of some cells. is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016612 name: molybdenum-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a molybdenum-iron cluster found in many species. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the molybdenum-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1] synonym: "molybdenum-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016613 name: vanadium-iron nitrogenase complex namespace: cellular_component def: "An enzyme complex containing a vanadium-iron cluster found in some species, such as Azotobacter vinelandii. It is composed of two proteins, dinitrogenase and nitrogenase reductase; dinitrogenase, the vanadium-iron protein, is tetrameric with an alpha2-beta2 structure, and nitrogenase reductase is a homodimer." [EC:1.18.6.1, PMID:3474027] synonym: "vanadium-iron nitrogenase activity" RELATED [] is_a: GO:0016610 ! nitrogenase complex [Term] id: GO:0016614 name: oxidoreductase activity, acting on CH-OH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.1.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" NARROW [] xref: EC:1.1 xref: reactome:R-HSA-1500781 "Fgd1 reactivates F420" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016615 name: malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible conversion of pyruvate or oxaloacetate to malate." [GOC:mah, ISBN:0582227089] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016616 name: oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [EC:1.1.1.-, GOC:ai] xref: EC:1.1.1 xref: reactome:R-HSA-975629 "RDH11 reduces RBP2:atRAL to RBP2:atROL" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016617 name: 4-oxoproline reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-L-proline + NAD+ = 4-oxoproline + NADH + H+." [EC:1.1.1.104] synonym: "4-hydroxy-L-proline:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.104] synonym: "hydroxy-L-proline oxidase activity" EXACT [] synonym: "hydroxyproline oxidase activity" EXACT [EC:1.1.1.104] xref: EC:1.1.1.104 xref: MetaCyc:4-OXOPROLINE-REDUCTASE-RXN xref: RHEA:13601 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016618 name: hydroxypyruvate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glycerate + NADP+ = hydroxypyruvate + NADPH + H+." [EC:1.1.1.81] synonym: "beta-hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate dehydrogenase activity" EXACT [EC:1.1.1.81] synonym: "D-glycerate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.81] synonym: "NADH:hydroxypyruvate reductase activity" EXACT [EC:1.1.1.81] xref: EC:1.1.1.81 xref: MetaCyc:HYDROXYPYRUVATE-REDUCTASE-RXN xref: MetaCyc:RXN0-300 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0016620 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.2.1 xref: reactome:R-HSA-1222583 "MscR reduces nitrosomycothiol to ammonia" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016621 name: cinnamoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: cinnamaldehyde + CoA + NADP+ = cinnamoyl-CoA + NADPH + H+." [EC:1.2.1.44] synonym: "cinnamaldehyde:NADP+ oxidoreductase (CoA-cinnamoylating)" EXACT [EC:1.2.1.44] synonym: "cinnamoyl CoA reductase activity" EXACT [] synonym: "cinnamoyl-CoA:NADPH reductase activity" EXACT [EC:1.2.1.44] synonym: "cinnamoyl-coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] synonym: "feruloyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "ferulyl-CoA reductase activity" EXACT [EC:1.2.1.44] synonym: "p-hydroxycinnamoyl coenzyme A reductase activity" EXACT [EC:1.2.1.44] xref: EC:1.2.1.44 xref: MetaCyc:CINNAMOYL-COA-REDUCTASE-RXN xref: RHEA:10620 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0016622 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.2.2 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016623 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.2.3 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016624 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulphide as acceptor" EXACT [] xref: EC:1.2.4 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016625 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.2.7 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0016626 name: obsolete oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces an acceptor other than NAD, NADP, oxygen, an iron-sulfur protein, disulphide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016903 [Term] id: GO:0016627 name: oxidoreductase activity, acting on the CH-CH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.3.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" NARROW [] xref: EC:1.3 xref: reactome:R-HSA-2995334 "COX15 transforms heme O to heme A" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016628 name: oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.3.1 xref: reactome:R-HSA-4419979 "SRD5A3 reduces pPNOL to DCHOL" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016629 name: 12-oxophytodienoate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-en-1-yl}cyclopentyl]octanoate + NADP(+) = (15Z)-12-oxophyto-10,15-dienoate + H(+) + NADPH." [EC:1.3.1.42, RHEA:21888] synonym: "12-oxo-phytodienoate reductase activity" EXACT [] synonym: "12-oxo-phytodienoic acid reductase activity" EXACT [EC:1.3.1.42] synonym: "8-[(1R,2R)-3-oxo-2-{(Z)-pent-2-enyl}cyclopentyl]octanoate:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.42] xref: EC:1.3.1.42 xref: KEGG:R03401 xref: MetaCyc:12-OXOPHYTODIENOATE-REDUCTASE-RXN xref: RHEA:21888 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016630 name: protochlorophyllide reductase activity namespace: molecular_function def: "Catalysis of the reaction: chlorophyllide a + NADP+ = protochlorophyllide + NADPH + H+." [EC:1.3.1.33] synonym: "chlorophyllide-a:NADP+ 7,8-oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH-protochlorophyllide reductase activity" EXACT [EC:1.3.1.33] synonym: "NADPH2-protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide oxidoreductase activity" EXACT [EC:1.3.1.33] synonym: "protochlorophyllide photooxidoreductase activity" EXACT [EC:1.3.1.33] xref: EC:1.3.1.33 xref: MetaCyc:RXN1F-10 xref: RHEA:11132 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016631 name: enoyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD(P)+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NAD(P)H + H+." [EC:1.3.1.9, GOC:rb] synonym: "acyl-ACP dehydrogenase activity" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "enoyl-ACP reductase activity" EXACT [] synonym: "enoyl-acyl carrier protein reductase" EXACT [] xref: EC:1.3.1.9 xref: MetaCyc:1.3.1.10-RXN xref: MetaCyc:1.3.1.39-RXN xref: MetaCyc:RXN1G-2527 xref: MetaCyc:RXN1G-2544 xref: MetaCyc:RXN1G-3232 xref: MetaCyc:RXN1G-3256 xref: MetaCyc:RXN1G-3613 xref: MetaCyc:RXN1G-3641 xref: MetaCyc:RXN1G-3667 xref: MetaCyc:RXN1G-3993 xref: MetaCyc:RXN1G-4140 xref: MetaCyc:RXN1G-45 xref: Wikipedia:Enoyl-acyl_carrier_protein_reductase is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016632 name: oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.3.2 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016633 name: galactonolactone dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactono-1,4-lactone + 2 ferricytochrome c = L-ascorbate + 2 ferrocytochrome c." [EC:1.3.2.3] synonym: "GLDase activity" EXACT [EC:1.3.2.3] synonym: "GLDHase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-1,4-lactone dehydrogenase activity" EXACT [] synonym: "L-galactono-1,4-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone dehydrogenase activity" EXACT [EC:1.3.2.3] synonym: "L-galactono-gamma-lactone:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.3.2.3] synonym: "L-galactonolactone dehydrogenase activity" EXACT [EC:1.3.2.3] xref: EC:1.3.2.3 xref: MetaCyc:GALACTONOLACTONE-DEHYDROGENASE-RXN is_a: GO:0016632 ! oxidoreductase activity, acting on the CH-CH group of donors, cytochrome as acceptor [Term] id: GO:0016634 name: oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.3.3 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016635 name: oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a quinone or related compound." [GOC:jl] xref: EC:1.3.5 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016636 name: oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-CH group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.3.7 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0016637 name: obsolete oxidoreductase activity, acting on the CH-CH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or related compound, a cytochrome, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-CH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016627 [Term] id: GO:0016638 name: oxidoreductase activity, acting on the CH-NH2 group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.4.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" NARROW [] xref: EC:1.4 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016639 name: oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] xref: EC:1.4.1 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016640 name: oxidoreductase activity, acting on the CH-NH2 group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.4.2 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016641 name: oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.4.3 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016642 name: oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, disulphide as acceptor" EXACT [] xref: EC:1.4.4 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016643 name: oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.4.7 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0016644 name: obsolete oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, an iron-sulfur protein, NAD, NADP or oxygen." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-NH2 group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016638 [Term] id: GO:0016645 name: oxidoreductase activity, acting on the CH-NH group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.5.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" NARROW [] xref: EC:1.5 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016646 name: oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.5.1 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016647 name: oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.5.3 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016648 name: oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on the CH-NH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.5.4 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016649 name: oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces quinone or similar compound." [GOC:jl] xref: EC:1.5.5 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0016650 name: obsolete oxidoreductase activity, acting on the CH-NH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or similar compound, disulfide, NAD, NADP, oxygen or a flavin." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-NH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016645 [Term] id: GO:0016651 name: oxidoreductase activity, acting on NAD(P)H namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.6.99.- should also be annotated to this term. synonym: "NAD(P)H dehydrogenase" NARROW [] synonym: "oxidoreductase activity, acting on NADH or NADPH" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" NARROW [] xref: EC:1.6 xref: reactome:R-HSA-109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: reactome:R-HSA-8956458 "RNLS:FAD oxidises dh-beta-NAD to NAD+" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016652 name: oxidoreductase activity, acting on NAD(P)H, NAD(P) as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] synonym: "oxidoreductase activity, acting on NAD or NADPH, NAD or NADP as acceptor" RELATED [] xref: EC:1.6.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016653 name: oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a heme protein." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, haem protein as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor" RELATED [] xref: EC:1.6.2 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016655 name: oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor" RELATED [] xref: EC:1.6.5 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016656 name: monodehydroascorbate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 monodehydroascorbate = NAD+ + 2 ascorbate." [EC:1.6.5.4] synonym: "AFR" RELATED [EC:1.6.5.4] synonym: "AFR-reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbate free-radical reductase activity" EXACT [EC:1.6.5.4] synonym: "ascorbic free radical reductase activity" EXACT [EC:1.6.5.4] synonym: "MDAsA reductase (NADPH)" EXACT [EC:1.6.5.4] synonym: "MDHA" RELATED [EC:1.6.5.4] synonym: "monodehydroascorbate reductase activity" EXACT [] synonym: "NADH-semidehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:AFR oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:ascorbate radical oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:monodehydroascorbate oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "NADH:semidehydroascorbic acid oxidoreductase activity" EXACT [EC:1.6.5.4] synonym: "SDA reductase activity" EXACT [EC:1.6.5.4] synonym: "semidehydroascorbate reductase activity" EXACT [EC:1.6.5.4] xref: EC:1.6.5.4 xref: MetaCyc:1.6.5.4-RXN xref: RHEA:14581 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0016657 name: oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:ai] synonym: "oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor" RELATED [] xref: EC:1.6.6 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0016658 name: obsolete oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it was a grouping term taken from EC that no longer has any functions associated with it. synonym: "oxidoreductase activity, acting on NADH or NADPH, flavin as acceptor" EXACT [] is_obsolete: true consider: GO:0008752 consider: GO:0042602 [Term] id: GO:0016659 name: obsolete oxidoreductase activity, acting on NADH or NADPH, other acceptor namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, a heme protein, NAD, NADP, a nitrogenous group, a quinone or similar compound or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on NADH or NADPH, other acceptor" EXACT [] is_obsolete: true consider: GO:0016651 [Term] id: GO:0016661 name: oxidoreductase activity, acting on other nitrogenous compounds as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.7.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" NARROW [] xref: EC:1.7 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016662 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.7.2 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016663 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] xref: EC:1.7.3 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016664 name: oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.7.7 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0016665 name: obsolete oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, oxygen, NAD or NADP." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on other nitrogenous compounds as donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016661 [Term] id: GO:0016667 name: oxidoreductase activity, acting on a sulfur group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.8.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" NARROW [] synonym: "oxidoreductase activity, acting on sulphur group of donors" EXACT [] xref: EC:1.8 xref: reactome:R-HSA-2213240 "Reduction of disulphide bonds in MHC II antigens" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016668 name: oxidoreductase activity, acting on a sulfur group of donors, NAD(P) as acceptor namespace: molecular_function alt_id: GO:0016654 def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] synonym: "oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor" RELATED [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulfide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on NADH or NADPH, disulphide as acceptor" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, NAD or NADP as acceptor" EXACT [] xref: EC:1.8.1 is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016669 name: oxidoreductase activity, acting on a sulfur group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, cytochrome as acceptor" EXACT [] xref: EC:1.8.2 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016670 name: oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, oxygen as acceptor" EXACT [] xref: EC:1.8.3 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016671 name: oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, disulphide as acceptor" EXACT [] xref: EC:1.8.4 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016672 name: oxidoreductase activity, acting on a sulfur group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces quinone or a related compound." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, quinone or similar compound as acceptor" EXACT [] xref: EC:1.8.5 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016673 name: oxidoreductase activity, acting on a sulfur group of donors, iron-sulfur protein as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on sulphur group of donors, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.8.7 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0016674 name: obsolete oxidoreductase activity, acting on sulfur group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces an acceptor other than quinone or a related compound, oxygen, NAD, NADP, an iron-sulfur protein, disulfide or a cytochrome." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on sulfur group of donors, other acceptors" EXACT [] synonym: "oxidoreductase activity, acting on sulphur group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016667 [Term] id: GO:0016675 name: oxidoreductase activity, acting on a heme group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.9.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on haem group of donors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" NARROW [] xref: EC:1.9 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016676 name: oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, oxygen as acceptor" EXACT [] xref: EC:1.9.3 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016677 name: oxidoreductase activity, acting on a heme group of donors, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces a nitrogenous group." [GOC:jl] synonym: "oxidoreductase activity, acting on haem group of donors, nitrogenous group as acceptor" EXACT [] xref: EC:1.9.6 is_a: GO:0016675 ! oxidoreductase activity, acting on a heme group of donors [Term] id: GO:0016678 name: obsolete oxidoreductase activity, acting on heme group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a heme group acts as a hydrogen or electron donor and reduces an acceptor other than a nitrogenous group or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on haem group of donors, other acceptors" EXACT [] synonym: "oxidoreductase activity, acting on heme group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016675 [Term] id: GO:0016679 name: oxidoreductase activity, acting on diphenols and related substances as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol or related substance acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.10.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" NARROW [] xref: EC:1.10 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016680 name: oxidoreductase activity, acting on diphenols and related substances as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.10.1 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016681 name: oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.10.2 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016682 name: oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces oxygen." [GOC:jl] synonym: "laccase activity" RELATED [GOC:jh] xref: EC:1.10.3 is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0016683 name: obsolete oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a diphenol, or related compound, acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on diphenols and related substances as donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016679 [Term] id: GO:0016684 name: oxidoreductase activity, acting on peroxide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the peroxide group acts as a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.11 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016688 name: L-ascorbate peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-ascorbate + hydrogen peroxide = dehydroascorbate + 2 H2O." [EC:1.11.1.11] synonym: "ascorbate peroxidase activity" EXACT [EC:1.11.1.11] synonym: "ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbate:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid peroxidase activity" EXACT [EC:1.11.1.11] synonym: "L-ascorbic acid-specific peroxidase activity" EXACT [EC:1.11.1.11] xref: EC:1.11.1.11 xref: MetaCyc:L-ASCORBATE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016689 name: manganese peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Mn2+ + 2 H+ + hydrogen peroxide = 2 Mn3+ + 2 H2O." [EC:1.11.1.13] synonym: "Mn(II):hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent (NADH-oxidizing) peroxidase activity" EXACT [EC:1.11.1.13] synonym: "Mn-dependent peroxidase activity" EXACT [EC:1.11.1.13] synonym: "peroxidase-M2" RELATED [EC:1.11.1.13] xref: EC:1.11.1.13 xref: MetaCyc:MANGANESE-PEROXIDASE-RXN xref: RHEA:22776 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016690 name: diarylpropane peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: (3,4-dimethoxyphenyl)methanol + H2O2 = 3,4-dimethoxybenzaldehyde + 2 H2O." [EC:1.11.1.14] synonym: "1,2-bis(3,4-dimethoxyphenyl)propane-1,3-diol:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane oxygenase activity" EXACT [EC:1.11.1.14] synonym: "diarylpropane:oxygen,hydrogen-peroxide oxidoreductase (C-C-bond-cleaving)" EXACT [EC:1.11.1.14] synonym: "lignin peroxidase activity" EXACT [EC:1.11.1.14] synonym: "ligninase activity" EXACT [EC:1.11.1.14] synonym: "ligninase I activity" NARROW [EC:1.11.1.14] synonym: "LiP activity" NARROW [EC:1.11.1.14] xref: EC:1.11.1.14 xref: MetaCyc:DIARYLPROPANE-PEROXIDASE-RXN xref: RHEA:30271 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016691 name: chloride peroxidase activity namespace: molecular_function alt_id: GO:0016955 alt_id: GO:0016956 alt_id: GO:0016957 alt_id: GO:0016958 def: "Catalysis of the reaction: 2 R-H + 2 chloride + hydrogen peroxide = 2 R-Cl + 2 H2O." [EC:1.11.1.10] synonym: "chloride:hydrogen-peroxide oxidoreductase" EXACT [EC:1.11.1.10] synonym: "chloroperoxidase activity" EXACT [EC:1.11.1.10] synonym: "cofactor-free chloroperoxidase activity" NARROW [] synonym: "flavin-haem chloroperoxidase activity" NARROW [] synonym: "flavin-heme chloroperoxidase activity" NARROW [] synonym: "haem chloroperoxidase activity" NARROW [] synonym: "heme chloroperoxidase activity" NARROW [] synonym: "vanadium chloroperoxidase activity" NARROW [] xref: EC:1.11.1.10 xref: MetaCyc:CHLORIDE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016692 name: NADH peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O(2) + H(+) + NADH = 2 H(2)O + NAD(+)." [EC:1.11.1.1, RHEA:18509] synonym: "diphosphopyridine nucleotide peroxidase activity" EXACT [EC:1.11.1.1] synonym: "DPNH peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NAD peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH-peroxidase activity" EXACT [EC:1.11.1.1] synonym: "NADH:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.1] synonym: "nicotinamide adenine dinucleotide peroxidase activity" EXACT [EC:1.11.1.1] xref: EC:1.11.1.1 xref: KEGG:R00090 xref: MetaCyc:NADH-PEROXIDASE-RXN xref: RHEA:18509 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0016694 name: obsolete bacterial catalase-peroxidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a bifunctional gene product. synonym: "bacterial catalase-peroxidase activity" EXACT [] is_obsolete: true consider: GO:0004096 consider: GO:0004601 [Term] id: GO:0016695 name: oxidoreductase activity, acting on hydrogen as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor." [GOC:jl] comment: Note that enzymes of class EC:1.12.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" NARROW [] xref: EC:1.12 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016696 name: oxidoreductase activity, acting on hydrogen as donor, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.12.1 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016697 name: oxidoreductase activity, acting on hydrogen as donor, cytochrome as acceptor namespace: molecular_function alt_id: GO:0016698 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces a cytochrome." [GOC:jl] xref: EC:1.12.2 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016699 name: oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor namespace: molecular_function alt_id: GO:0016736 alt_id: GO:0019110 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen acts as an electron donor and reduces an iron-sulfur protein." [GOC:jl] synonym: "oxidoreductase activity, acting on hydrogen as donor, iron-sulphur protein as acceptor" EXACT [] xref: EC:1.12.7 is_a: GO:0016695 ! oxidoreductase activity, acting on hydrogen as donor [Term] id: GO:0016700 name: obsolete oxidoreductase activity, acting on hydrogen as donor, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which hydrogen is the electron donor and reduces an acceptor other than a cytochrome, an iron-sulfur protein, NAD, NADP or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on hydrogen as donor, other acceptors" EXACT [] is_obsolete: true consider: GO:0016695 [Term] id: GO:0016701 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and molecular oxygen is incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.13.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" NARROW [] synonym: "oxygenase" BROAD [] xref: EC:1.13 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016702 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor." [GOC:mah] xref: EC:1.13.11 xref: reactome:R-HSA-2161775 "ALOX12 oxidises LTA4 to LXA4/B4" xref: reactome:R-HSA-2161907 "ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4" xref: reactome:R-HSA-2161917 "ALOX5 oxidises 15S-HpETE to LXA4/B4" xref: reactome:R-HSA-5164399 "BCO2:Fe2+ cleaves betaC to APO10al and bION" xref: reactome:R-HSA-9018880 "Ac-PTGS2 dimer oxidises EPA to 18(R)-HpEPE or 18(S)-HpEPE" xref: reactome:R-HSA-9020274 "ALOX12:Fe2+ oxidises DHA to 14(S)-Hp-DHA" xref: reactome:R-HSA-9026408 "PTGS2 dimer oxidises DPAn-3 to 13(R)-HDPAn-3" xref: reactome:R-HSA-9026918 "Lipoxygenase oxidises 17(S)-Hp-DHA to 7(S),17(S)-diHp-DHA" is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016703 name: oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and one oxygen atom is incorporated into a donor." [GOC:mah] xref: EC:1.13.12 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0016704 name: obsolete oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases acting on single donors with incorporation of molecular oxygen that cannot be more accurated categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, miscellaneous" EXACT [] is_obsolete: true consider: GO:0016701 [Term] id: GO:0016705 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor." [GOC:mah] comment: Note that enzymes of class EC:1.14.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" NARROW [] xref: EC:1.14 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016706 name: 2-oxoglutarate-dependent dioxygenase activity namespace: molecular_function alt_id: GO:0010302 def: "Catalysis of the reaction: A + 2-oxoglutarate + O2 = B + succinate + CO2. This is an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from 2-oxoglutarate and one other donor, and one atom of oxygen is incorporated into each donor." [GOC:mah] synonym: "2-oxoglutarate dioxygenase activity" EXACT [] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors" EXACT [] xref: EC:1.14.11 xref: reactome:R-HSA-1234164 "Cytosolic hydroxylation of asparagine residue in HIF alpha" xref: reactome:R-HSA-6783455 "TYW5 hydroxylates yW-72 yielding OHyW-72 at nucleotide 37 of tRNA(Phe)" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016707 name: gibberellin 3-beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a gibberellin + 2-oxoglutarate + O2 = a 3-beta-hydroxy-gibberellin + succinate + CO2." [EC:1.14.11.15, GOC:kad] synonym: "(gibberellin-20),2-oxoglutarate:oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "(gibberrellin-20),2-oxoglutarate: oxygen oxidoreductase (3beta-hydroxylating)" NARROW [EC:1.14.11.15] synonym: "gibberellin 3-beta-hydroxylase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-dioxygenase activity" EXACT [EC:1.14.11.15] synonym: "gibberellin 3beta-hydroxylase activity" EXACT [EC:1.14.11.15] xref: EC:1.14.11.15 xref: MetaCyc:RXN1F-170 xref: RHEA:10104 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0016708 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and two atoms of oxygen are incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor" RELATED [] xref: EC:1.14.12 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0016709 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from NADH or NADPH and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen" RELATED [] xref: EC:1.14.13 xref: reactome:R-HSA-2162187 "DHB is hydroxylated to DHDB by COQ6" xref: reactome:R-HSA-2162194 "COQ9 dimer:COQ7:Fe2+ hydroxylates DMQ10H2 to DeMQ10H2" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016710 name: trans-cinnamate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-cinnamate + NADPH + H+ + O2 = 4-hydroxycinnamate + NADP+ + H2O." [EC:1.14.13.11] synonym: "CA4H activity" NARROW [EC:1.14.13.11] synonym: "cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamate hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid 4-monooxygenase activity" EXACT [EC:1.14.13.11] synonym: "cinnamic acid p-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "cytochrome P450 cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "hydroxylase, cinnamate 4-" EXACT [EC:1.14.13.11] synonym: "oxygenase, cinnamate 4-mono-" EXACT [EC:1.14.13.11] synonym: "t-cinnamic acid hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate 4-hydroxylase activity" EXACT [EC:1.14.13.11] synonym: "trans-cinnamate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.11] synonym: "trans-cinnamic acid 4-hydroxylase activity" EXACT [EC:1.14.13.11] xref: EC:1.14.13.11 xref: MetaCyc:TRANS-CINNAMATE-4-MONOOXYGENASE-RXN xref: RHEA:10608 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016711 name: flavonoid 3'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a flavonoid + NADPH + H+ + O2 = 3'-hydroxyflavonoid + NADP+ + H2O." [EC:1.14.13.21] synonym: "flavonoid 3'-hydroxylase activity" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-hydroxylase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid 3-monooxygenase (erroneous)" EXACT [EC:1.14.13.21] synonym: "flavonoid,NADPH:oxygen oxidoreductase (3'-hydroxylating)" EXACT [EC:1.14.13.21] synonym: "NADPH:flavonoid-3'-hydroxylase activity" EXACT [EC:1.14.13.21] xref: EC:1.14.13.21 xref: MetaCyc:FLAVONOID-3-MONOOXYGENASE-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0016712 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen namespace: molecular_function alt_id: GO:0008402 alt_id: GO:0050381 def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced flavin or flavoprotein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "aryl hydrocarbon hydroxylase activity" NARROW [EC:1.14.14.1] synonym: "aryl-4-monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "cytochrome p450 activity" NARROW [EC:1.14.14.1] synonym: "cytochrome P450 CYP19" NARROW [] synonym: "flavoprotein monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "flavoprotein-linked monooxygenase activity" EXACT [EC:1.14.14.1] synonym: "microsomal monooxygenase activity" NARROW [EC:1.14.14.1] synonym: "microsomal P-450" RELATED [EC:1.14.14.1] synonym: "microsomal p450 activity" NARROW [EC:1.14.14.1] synonym: "substrate,reduced-flavoprotein:oxygen oxidoreductase (RH-hydroxylating or -epoxidizing)" EXACT [EC:1.14.14.1] synonym: "unspecific monooxygenase activity" RELATED [] synonym: "xenobiotic monooxygenase activity" RELATED [EC:1.14.14.1] xref: EC:1.14.14 xref: reactome:R-HSA-211966 "CYP2D6 4-hydroxylates debrisoquine" xref: UM-BBD_enzymeID:e0551 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016713 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced iron-sulfur protein and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulphur protein as one donor, and incorporation of one atom of oxygen" EXACT [] xref: EC:1.14.15 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016714 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced pteridine and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.16 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016715 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from reduced ascorbate and one other donor, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.17 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016716 name: oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and one atom of oxygen is incorporated into one donor." [GOC:mah] xref: EC:1.14.18 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016717 name: oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced to two molecules of water." [GOC:mah] xref: EC:1.14.19 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016718 name: obsolete oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductases, acting on paired donors with incorporation or reduction of molecular oxygen, that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, miscellaneous" EXACT [] is_obsolete: true consider: GO:0016705 [Term] id: GO:0016719 name: carotene 7,8-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: neurosporene + donor-H2 + O2 = lycopene + acceptor + 2 H2O." [EC:1.14.99.30] comment: This term represents a deleted EC activity and is scheduled for obsoletion. synonym: "carotene,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.30] synonym: "zeta-carotene desaturase activity" EXACT [EC:1.14.99.30] xref: EC:1.14.99.30 xref: MetaCyc:1.14.99.30-RXN xref: RHEA:15701 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016720 name: delta12-fatty acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: AH(2) + linoleate + O(2) = A + crepenynate + 2 H(2)O." [EC:1.14.99.33, RHEA:23456] synonym: "crepenynate synthase activity" NARROW [EC:1.14.99.33] synonym: "D12-fatty acid dehydrogenase activity" EXACT [] synonym: "delta-12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "delta12 fatty acid acetylenase activity" EXACT [EC:1.14.99.33] synonym: "linoleate delta-12-fatty acid acetylenase (desaturase) activity" EXACT [] synonym: "linoleate delta12-fatty acid acetylenase (desaturase)" EXACT [EC:1.14.99.33] synonym: "linoleate, hydrogen-donor:oxygen oxidoreductase (Delta12-unsaturating)" EXACT [EC:1.14.99.33] xref: EC:1.14.99.33 xref: KEGG:R05740 xref: MetaCyc:1.14.99.33-RXN xref: RHEA:23456 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0016721 name: oxidoreductase activity, acting on superoxide radicals as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a superoxide radical (O2- or O2.-) acts as a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.15 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016722 name: oxidoreductase activity, oxidizing metal ions namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered." [GOC:mah] xref: EC:1.16 xref: reactome:R-HSA-917805 "CYBRD1:Heme reduces Fe3+ to Fe2+" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016723 name: oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and NAD+ or NADP+ acts as an electron acceptor." [GOC:mah] xref: EC:1.16.1 xref: reactome:R-HSA-917811 "STEAP3-like proteins reduce Fe3+ to Fe2+" is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016724 name: oxidoreductase activity, oxidizing metal ions, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered and oxygen acts as an electron acceptor." [GOC:mah] xref: EC:1.16.3 is_a: GO:0016722 ! oxidoreductase activity, oxidizing metal ions [Term] id: GO:0016725 name: oxidoreductase activity, acting on CH or CH2 groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.17.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on CH or CH2 groups, other acceptors" NARROW [] xref: EC:1.17 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016726 name: oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP." [GOC:ai] xref: EC:1.17.1 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016727 name: oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.17.3 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016728 name: oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces a disulfide group." [GOC:ai] synonym: "oxidoreductase activity, acting on CH or CH2 groups, disulphide as acceptor" EXACT [] xref: EC:1.17.4 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0016729 name: obsolete oxidoreductase activity, acting on CH2 groups, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH2 group acts as a hydrogen or electron donor and reduces an acceptor other than disulfide, NAD, NADP or oxygen." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on CH2 groups, other acceptors" EXACT [] is_obsolete: true consider: GO:0016725 [Term] id: GO:0016730 name: oxidoreductase activity, acting on iron-sulfur proteins as donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] synonym: "oxidoreductase activity, acting on iron-sulphur proteins as donors" EXACT [] xref: EC:1.18 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016731 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP." [GOC:jl] xref: EC:1.18.1 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016732 name: oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] xref: EC:1.18.6 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0016733 name: obsolete iron-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "iron-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016611 [Term] id: GO:0016734 name: obsolete molybdenum-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + N2 + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "molybdenum-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016612 [Term] id: GO:0016735 name: obsolete vanadium-iron nitrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 8 reduced ferredoxin + 8 H+ + nitrogen + 16 ATP = 8 oxidized ferredoxin + 2 NH3 + 16 ADP + 16 phosphate." [EC:1.18.6.1] comment: This term was made obsolete because it represents a cellular component. synonym: "vanadium-iron nitrogenase activity" EXACT [] is_obsolete: true consider: GO:0016163 consider: GO:0016613 [Term] id: GO:0016737 name: oxidoreductase activity, acting on reduced flavodoxin as donor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] xref: EC:1.19 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016738 name: oxidoreductase activity, acting on reduced flavodoxin as donor, dinitrogen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which reduced flavodoxin acts as a hydrogen or electron donor and reduces dinitrogen." [GOC:jl] xref: EC:1.19.6 is_a: GO:0016737 ! oxidoreductase activity, acting on reduced flavodoxin as donor [Term] id: GO:0016739 name: obsolete oxidoreductase activity, acting on other substrates namespace: molecular_function def: "OBSOLETE. A grouping term for oxidoreductase that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on other substrates" EXACT [] is_obsolete: true consider: GO:0016491 [Term] id: GO:0016740 name: transferase activity namespace: molecular_function def: "Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:2 xref: reactome:R-HSA-1483089 "PE is converted to PS by PTDSS2" xref: reactome:R-HSA-1483186 "PC is converted to PS by PTDSS1" xref: reactome:R-HSA-5668414 "TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK" xref: reactome:R-HSA-6787403 "GTPBP3 and MTO1 transform uridine-34 yielding 5-taurinomethyluridine-34 in tRNA" xref: reactome:R-HSA-8868783 "TSR3 transfers aminocarboxypropyl group from S-adenosylmethionine to N(1)-methylpseudouridine-1248 of 18SE rRNA yielding N(1)-methyl-N(3)-aminocarboxypropylpseudouridine-1248" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016741 name: transferase activity, transferring one-carbon groups namespace: molecular_function def: "Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] xref: EC:2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016742 name: hydroxymethyl-, formyl- and related transferase activity namespace: molecular_function def: "Catalysis of the transfer of a hydroxymethyl- or formyl group from one compound (donor) to another (acceptor)." [EC:2.1.2, GOC:mah] xref: EC:2.1.2 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016743 name: carboxyl- or carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "carboxyl- and carbamoyltransferase activity" EXACT [] xref: EC:2.1.3 is_a: GO:0016741 ! transferase activity, transferring one-carbon groups [Term] id: GO:0016744 name: transferase activity, transferring aldehyde or ketonic groups namespace: molecular_function alt_id: GO:0016745 def: "Catalysis of the transfer of an aldehyde or ketonic group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "transketolase or transaldolase activity" EXACT [] xref: EC:2.2 xref: EC:2.2.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016746 name: transferase activity, transferring acyl groups namespace: molecular_function alt_id: GO:0008415 def: "Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic synonym: "acyltransferase activity" EXACT [] xref: EC:2.3 xref: reactome:R-HSA-159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: reactome:R-HSA-192312 "Choloyl CoA reacts with glycine or taurine to form glycocholate or taurocholate" xref: reactome:R-HSA-193491 "Chenodeoxycholoyl CoA reacts with glycine or taurine to form glycochenodeoxycholate or taurochenodeoxycholate" xref: reactome:R-HSA-6792572 "LIPT1 transfers lipoyl group from lipoyl-GCSH to DHs" xref: reactome:R-HSA-8858298 "HRASLS transfer acyl group from PC to PE to form NAPE" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016747 name: transferase activity, transferring acyl groups other than amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "transferase activity, transferring groups other than amino-acyl groups" EXACT [EC:2.3.1] xref: EC:2.3.1 is_a: GO:0016746 ! transferase activity, transferring acyl groups [Term] id: GO:0016748 name: succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl (3-carboxypropanoyl) group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016749 name: N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016750 name: O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016751 name: S-succinyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a succinyl group to a sulfur atom on the acceptor molecule." [GOC:ai] is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0016748 ! succinyltransferase activity [Term] id: GO:0016752 name: sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an acceptor molecule." [GOC:ai] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0016753 name: O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sinapoyl group to an oxygen atom on the acceptor molecule." [GOC:ai] is_a: GO:0008374 ! O-acyltransferase activity is_a: GO:0016752 ! sinapoyltransferase activity [Term] id: GO:0016754 name: sinapoylglucose-malate O-sinapoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + 1-O-sinapoyl-beta-D-glucose = D-glucose + sinapoyl (S)-malate." [EC:2.3.1.92, RHEA:12625] synonym: "1-O-sinapoyl-beta-D-glucose:(S)-malate O-sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "1-sinapoylglucose-L-malate sinapoyltransferase activity" EXACT [EC:2.3.1.92] synonym: "sinapoylglucose:malate sinapoyltransferase activity" EXACT [] xref: EC:2.3.1.92 xref: KEGG:R03323 xref: MetaCyc:2.3.1.92-RXN xref: RHEA:12625 is_a: GO:0016753 ! O-sinapoyltransferase activity [Term] id: GO:0016755 name: transferase activity, transferring amino-acyl groups namespace: molecular_function def: "Catalysis of the transfer of an amino-acyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "aminoacyltransferase activity" EXACT [] xref: EC:2.3.2 is_a: GO:0016746 ! transferase activity, transferring acyl groups is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016756 name: glutathione gamma-glutamylcysteinyltransferase activity namespace: molecular_function alt_id: GO:0042143 def: "Catalysis of the reaction: glutathione + Glu(-Cys)(n)-Gly = Gly + Glu(-Cys)(n+1)-Gly." [EC:2.3.2.15] synonym: "gamma-glutamylcysteine dipeptidyl transpeptidase activity" EXACT [EC:2.3.2.15] synonym: "glutathione:poly(4-glutamyl-cysteinyl)glycine 4-glutamylcysteinyltransferase activity" EXACT [EC:2.3.2.15] synonym: "phytochelatin synthase activity" EXACT [EC:2.3.2.15] xref: EC:2.3.2.15 xref: MetaCyc:2.3.2.15-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0016757 name: transferase activity, transferring glycosyl groups namespace: molecular_function alt_id: GO:0016932 def: "Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.4.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "glycosyltransferase activity" EXACT [] synonym: "transferase activity, transferring other glycosyl groups" NARROW [] synonym: "transglycosidase activity" EXACT [] synonym: "transglycosylase activity" EXACT [] xref: EC:2.4 xref: reactome:R-HSA-5173005 "B3GALTL transfers glucose to O-fucosyl-proteins" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016758 name: transferase activity, transferring hexosyl groups namespace: molecular_function def: "Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "hexosyltransferase activity" EXACT [] xref: EC:2.4.1 is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016759 name: cellulose synthase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside-disphosphate-glucose + ((1,4)-beta-D-glucosyl)(n) = nucleoside-disphosphate + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12, EC:2.4.1.29] synonym: "cellulose synthetase activity" EXACT [EC:2.4.1.29] is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0016760 name: cellulose synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + ((1,4)-beta-D-glucosyl)(n) = UDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.12] synonym: "1,4-beta-D-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "1,4-beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucan synthetase activity" EXACT [EC:2.4.1.12] synonym: "beta-1,4-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "beta-glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "glucan synthase activity" EXACT [EC:2.4.1.12] synonym: "GS-I" RELATED [EC:2.4.1.12] synonym: "UDP-glucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "UDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.12] synonym: "uridine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.12] xref: EC:2.4.1.12 xref: MetaCyc:CELLULOSE-SYNTHASE-UDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016761 name: cellulose synthase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GDP-glucose + ((1,4)-beta-D-glucosyl)(n) = GDP + ((1,4)-beta-D-glucosyl)(n+1)." [EC:2.4.1.29] synonym: "cellulose synthase (guanosine diphosphate-forming) activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDP-glucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "GDPglucose:1,4-beta-D-glucan 4-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-1,4-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.29] synonym: "guanosine diphosphoglucose-cellulose glucosyltransferase activity" EXACT [EC:2.4.1.29] xref: EC:2.4.1.29 xref: MetaCyc:CELLULOSE-SYNTHASE-GDP-FORMING-RXN is_a: GO:0016759 ! cellulose synthase activity [Term] id: GO:0016762 name: xyloglucan:xyloglucosyl transferase activity namespace: molecular_function alt_id: GO:0080039 def: "Catalysis of the cleavage of a beta-(1->4) bond in the backbone of a xyloglucan and transfers the xyloglucanyl segment on to O-4 of the non-reducing terminal glucose residue of an acceptor, which can be a xyloglucan or an oligosaccharide of xyloglucan." [EC:2.4.1.207, GOC:ask, PMID:1400418, PMID:1554366] synonym: "endo-xyloglucan transferase activity" EXACT [EC:2.4.1.207] synonym: "endoxyloglucan transferase activity" EXACT [] synonym: "xyloglucan endotransglucosylase activity" EXACT [EC:2.4.1.207] synonym: "xyloglucan:xyloglucan xyloglucanotransferase activity" EXACT [EC:2.4.1.207] xref: EC:2.4.1.207 xref: MetaCyc:2.4.1.207-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0016763 name: transferase activity, transferring pentosyl groups namespace: molecular_function def: "Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor)." [GOC:jl] synonym: "pentosyltransferase activity" EXACT [] xref: EC:2.4.2 xref: reactome:R-HSA-112265 "thymidine or deoxyuridine + orthophosphate <=> thymine or uracil + 2-deoxy-D-ribose 1-phosphate [TYMP]" xref: reactome:R-HSA-112266 "thymine or uracil + 2-deoxy-D-ribose 1-phosphate <=> thymidine or deoxyuridine + orthophosphate [TYMP]" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0016764 name: obsolete transferase activity, transferring other glycosyl groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a glycosyl group, other than hexosyl or pentosyl, from one compound (donor) to another (acceptor)." [GOC:jl] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "transferase activity, transferring other glycosyl groups" EXACT [] is_obsolete: true consider: GO:0016757 [Term] id: GO:0016765 name: transferase activity, transferring alkyl or aryl (other than methyl) groups namespace: molecular_function alt_id: GO:0016766 def: "Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] subset: goslim_chembl subset: goslim_generic synonym: "transferase activity, transferring alkyl or aryl groups, other than methyl groups" EXACT [] xref: EC:2.5 xref: EC:2.5.1 xref: reactome:R-HSA-4419978 "DHDDS:NUS1 elongates E,E-FPP with (n)IPPP to form pPPP" xref: reactome:R-HSA-6782893 "TRMT12 transforms yW-187 yielding yW-86 at nucleotide 37 of tRNA(Phe)" is_a: GO:0016740 ! transferase activity [Term] id: GO:0016767 name: geranylgeranyl-diphosphate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate = diphosphate + prephytoene diphosphate." [EC:2.5.1.32] synonym: "geranylgeranyl-diphosphate:geranylgeranyl-diphosphate geranylgeranyltransferase activity" EXACT [EC:2.5.1.32] synonym: "phytoene synthetase activity" EXACT [EC:2.5.1.32] synonym: "prephytoene-diphosphate synthase activity" EXACT [EC:2.5.1.32] synonym: "PSase activity" EXACT [EC:2.5.1.32] xref: EC:2.5.1.32 xref: MetaCyc:2.5.1.32-RXN xref: RHEA:22296 is_a: GO:0004337 ! geranyltranstransferase activity [Term] id: GO:0016768 name: spermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine." [EC:2.5.1.22] synonym: "S-adenosylmethioninamine:spermidine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermidine aminopropyltransferase activity" EXACT [EC:2.5.1.22] synonym: "spermine synthetase activity" EXACT [EC:2.5.1.22] xref: EC:2.5.1.22 xref: MetaCyc:SPERMINE-SYNTHASE-RXN xref: reactome:R-HSA-351210 "dc-Adenosyl methionine + Spermidine => Spermine + 5'-methylthioadenosine" xref: RHEA:19973 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0016769 name: transferase activity, transferring nitrogenous groups namespace: molecular_function def: "Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that enzymes of class EC:2.6.99.- should also be annotated to this term. synonym: "transferase activity, transferring other nitrogenous groups" NARROW [] xref: EC:2.6 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016770 name: oximinotransaminase activity namespace: molecular_function def: "Catalysis of the reversible transfer of an oxime group to an acceptor." [GOC:ai] xref: EC:2.6.3 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0016771 name: obsolete transferase activity, transferring other nitrogenous groups namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a nitrogenous group, other than amino, amidino or oxime, from one compound (donor) to another (acceptor)." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "transferase activity, transferring other nitrogenous groups" EXACT [] is_obsolete: true consider: GO:0016769 [Term] id: GO:0016772 name: transferase activity, transferring phosphorus-containing groups namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] comment: Note that this term encompasses all kinase activities, as well as activities that transfer other phosphorus-containing groups such as diphosphate or nucleotides. subset: goslim_chembl xref: EC:2.7 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016773 name: phosphotransferase activity, alcohol group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor)." [GOC:jl] xref: EC:2.7.1 xref: reactome:R-HSA-2161193 "abacavir + AMP => abacavir monophosphate + adenosine" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016774 name: phosphotransferase activity, carboxyl group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor)." [GOC:jl] xref: EC:2.7.2 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016775 name: phosphotransferase activity, nitrogenous group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a nitrogenous group (acceptor)." [GOC:jl] xref: EC:2.7.3 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016776 name: phosphotransferase activity, phosphate group as acceptor namespace: molecular_function def: "Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a phosphate group (acceptor)." [GOC:jl] xref: EC:2.7.4 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016778 name: diphosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a diphosphate group from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.6 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016779 name: nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a nucleotidyl group to a reactant." [ISBN:0198506732] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast xref: EC:2.7.7 xref: reactome:R-HSA-6782434 "TRG1L transfers GMP to 5' end of tRNA(His)" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016780 name: phosphotransferase activity, for other substituted phosphate groups namespace: molecular_function def: "Catalysis of the transfer of a substituted phosphate group, other than diphosphate or nucleotidyl residues, from one compound (donor) to a another (acceptor)." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.8 xref: reactome:R-HSA-162742 "(ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI -> (ethanolamineP) mannose (a1-2) (ethanolamineP) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI" xref: reactome:R-HSA-163069 "mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI + phosphatidylethanolamine -> (ethanolamineP) mannose (a1-2) mannose (a1-6) (ethanolamineP) mannose (a1-4) glucosaminyl-acyl-PI (acyl-GPI) + diacylglycerol" is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016781 name: phosphotransferase activity, paired acceptors namespace: molecular_function def: "Catalysis of the transfer of two phosphate groups from a donor, such as ATP, to two different acceptors." [GOC:jl, http://www.chem.qmul.ac.uk/iubmb/enzyme/EC2/intro.html] xref: EC:2.7.9 is_a: GO:0016772 ! transferase activity, transferring phosphorus-containing groups [Term] id: GO:0016782 name: transferase activity, transferring sulfur-containing groups namespace: molecular_function def: "Catalysis of the transfer of a sulfur-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "transferase activity, transferring sulphur-containing groups" EXACT [] xref: EC:2.8 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016783 name: sulfurtransferase activity namespace: molecular_function def: "Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor)." [GOC:ai, ISBN:0721662544] synonym: "sulphurtransferase activity" EXACT [] synonym: "tRNA sulfurtransferase activity" NARROW [GOC:mah] xref: EC:2.8.1 xref: reactome:R-HSA-1614618 "Persulfide sulfur is transferred onto sulfite" xref: reactome:R-HSA-6782264 "CTU1:CTU2:URM1 thiolates uridine-34 in tRNAs" xref: reactome:R-HSA-947538 "Transfer of sulfur from MOCS3-S-S onto MOCS2A" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0016784 name: 3-mercaptopyruvate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-mercaptopyruvate + cyanide = pyruvate + thiocyanate." [EC:2.8.1.2] synonym: "3-mercaptopyruvate sulphurtransferase activity" EXACT [] synonym: "3-mercaptopyruvate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "beta-mercaptopyruvate sulfurtransferase activity" EXACT [EC:2.8.1.2] synonym: "mercaptopyruvate sulfurtransferase activity" EXACT [] xref: EC:2.8.1.2 xref: MetaCyc:MERCAPYSTRANS-RXN xref: reactome:R-HSA-9012721 "MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR" xref: reactome:R-HSA-9013471 "MPST transfers sulfur from 3MPYR to HCN to form HSCN" xref: reactome:R-HSA-9013533 "MPST transfers sulfur from sulfanegen to HCN to form HSCN" xref: reactome:R-HSA-9034756 "MPST transfers sulfur atom from 3MPYR to form CysS248-MPST" xref: RHEA:21740 is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0016785 name: transferase activity, transferring selenium-containing groups namespace: molecular_function alt_id: GO:0016786 def: "Catalysis of the transfer of a selenium-containing group from one compound (donor) to another (acceptor)." [GOC:jl, ISBN:0198506732] synonym: "selenotransferase activity" EXACT [] xref: EC:2.9 xref: EC:2.9.1 is_a: GO:0016740 ! transferase activity [Term] id: GO:0016787 name: hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3." [ISBN:0198506732] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: EC:3 xref: reactome:R-HSA-1236938 "Partial proteolysis of antigen in phagolysosomes" xref: reactome:R-HSA-2029475 "Production of AA by iPLA2 upon FCGR activation" xref: reactome:R-HSA-5694583 "ABHD4 hydrolyses NAPE" xref: reactome:R-HSA-5695964 "ABHD14B hydrolyses PNPB" xref: reactome:R-HSA-6786190 "CMBL hydrolyses OM to OLMS" xref: reactome:R-HSA-6788295 "HDHD1:Mg2+ dephosphorylates PURIDP" xref: reactome:R-HSA-8938314 "ENPPs hydrolyse CoA-SH to PPANT, PAP" xref: reactome:R-HSA-8952137 "Phospholipid phosphatase 6 hydrolyses Presqualene diphosphate to presqualene monophosphate" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016788 name: hydrolase activity, acting on ester bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ester bond." [GOC:jl] subset: goslim_chembl synonym: "esterase activity" EXACT [] xref: EC:3.1 xref: reactome:R-HSA-162729 "uPAR-acyl-GPI + H2O -> uPAR + long-chain fatty acid" xref: reactome:R-HSA-9023617 "Butyrylcholinesterase hydrolyzes acyl Ghrelin" xref: reactome:R-HSA-9023619 "Platelet-activating factor acetylhydrolase (PLA2G7) hydrolyzes acyl Ghrelin" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016790 name: thiolester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A." [http://www.onelook.com] synonym: "thiolesterase activity" EXACT [] xref: EC:3.1.2 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0016791 name: phosphatase activity namespace: molecular_function alt_id: GO:0003869 alt_id: GO:0016302 def: "Catalysis of the hydrolysis of phosphoric monoesters, releasing inorganic phosphate." [EC:3.1.3, GOC:curators, GOC:pg] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_yeast synonym: "4-nitrophenylphosphatase activity" NARROW [] synonym: "4-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "K-pNPPase activity" NARROW [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "NPPase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" NARROW [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" NARROW [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" NARROW [EC:3.1.3.41] synonym: "phosphatase" RELATED [] synonym: "phosphoric monoester hydrolase activity" EXACT [] synonym: "PNPPase activity" NARROW [EC:3.1.3.41] xref: EC:3.1.3 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN xref: reactome:R-HSA-4419986 "Unknown pPPP phosphatase dephosphorylates pPPP to pPNOL" xref: RHEA:21664 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016793 name: triphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group." [GOC:ai] xref: EC:3.1.5 xref: reactome:R-HSA-8866601 "SAMHD1:Zn2+ tetramer hydrolyzes dNTP to nucleoside and triphosphate" is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016794 name: diphosphoric monoester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a diphosphoester to give a diphosphate group and a free hydroxyl group." [GOC:ai] xref: EC:3.1.7 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016795 name: phosphoric triester hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a phosphoric triester." [EC:3.1.8, GOC:curators] xref: EC:3.1.8 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0016796 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.15 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016797 name: exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. xref: EC:3.1.16 is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0016798 name: hydrolase activity, acting on glycosyl bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any glycosyl bond." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "glycosidase activity" EXACT [] synonym: "glycosylase" NARROW [] synonym: "N-glycosylase" NARROW [] xref: EC:3.2 xref: reactome:R-HSA-1793176 "DS is cleaved from its proteoglycan" xref: reactome:R-HSA-2065233 "CS is cleaved from its proteoglycan" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016799 name: hydrolase activity, hydrolyzing N-glycosyl compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any N-glycosyl bond." [GOC:jl] xref: EC:3.2.2 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0016801 name: hydrolase activity, acting on ether bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any ether or thioether bond, -O- or -S- respectively." [GOC:ai, GOC:jl] xref: EC:3.3 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016802 name: trialkylsulfonium hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a thioether bond, -S-." [EC:3.3.1.-, GOC:ai] synonym: "thioether hydrolase activity" EXACT [] synonym: "trialkylsulphonium hydrolase activity" EXACT [] xref: EC:3.3.1 is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016803 name: ether hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an ether bond, -O-." [EC:3.3.2.-, GOC:ai] xref: EC:3.3.2 xref: reactome:R-HSA-8874435 "THEM86B hydrolyses PMCHO, PMETAM" is_a: GO:0016801 ! hydrolase activity, acting on ether bonds [Term] id: GO:0016804 name: obsolete prolyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal proline from a peptide." [EC:3.4.11.5] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. synonym: "cytosol aminopeptidase V" RELATED [EC:3.4.11.5] synonym: "Pro-X aminopeptidase activity" EXACT [EC:3.4.11.5] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.5] synonym: "proline iminopeptidase activity" EXACT [] synonym: "prolyl aminopeptidase activity" EXACT [] xref: EC:3.4.11.5 xref: MetaCyc:3.4.11.5-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0016805 name: dipeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a dipeptide." [http://www.onelook.com] xref: EC:3.4.13 xref: reactome:R-HSA-266012 "LTD4 is converted to LTE4 by DPEP1/2" xref: reactome:R-HSA-5433067 "DPEPs hydrolyse glycine from AFXBO-CG, AFNBO-CG" xref: reactome:R-HSA-5693783 "NAALADases hydrolyse NAAG" xref: reactome:R-HSA-9026771 "DPEP hydroyses MCTR2 to MCTR3" is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0016806 name: obsolete dipeptidyl-peptidase and tripeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of N-terminal di- or tripeptides from a polypeptide chain." [GOC:ai] comment: This term was made obsolete because it represents two activities. synonym: "dipeptidyl-peptidase and tripeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14 is_obsolete: true [Term] id: GO:0016807 name: cysteine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/glossary.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/glossary.htm#CATTYPE] xref: EC:3.4.18 xref: MetaCyc:3.4.18.1-RXN is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070004 ! cysteine-type exopeptidase activity [Term] id: GO:0016808 name: obsolete proprotein convertase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "proprotein convertase activity" EXACT [] xref: EC:3.4.21 is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0016810 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds." [GOC:jl] comment: Note that enzymes of class EC:3.5.99.- should also be annotated to this term. subset: goslim_chembl subset: goslim_generic synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" NARROW [] xref: EC:3.5 xref: reactome:R-HSA-6803753 "NAAA hydrolyses NAEs to FAs and ethanolamine" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016811 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide." [GOC:ai] xref: EC:3.5.1 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016812 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amide." [GOC:ai] xref: EC:3.5.2 xref: reactome:R-HSA-70906 "4-imidazolone-5-propionate + H2O => N-formiminoglutamate + 2H+" is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016813 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] xref: EC:3.5.3 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016814 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2." [ISBN:0198506732] xref: EC:3.5.4 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016815 name: hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a nitrile, a compound containing the cyano radical, -CN." [http://www.onelook.com/] xref: EC:3.5.5 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0016816 name: obsolete hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in substances other than amides, amidines and nitriles." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in other compounds" EXACT [] is_obsolete: true consider: GO:0016810 [Term] id: GO:0016817 name: hydrolase activity, acting on acid anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride." [GOC:jl] synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" NARROW [] xref: EC:3.6 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016818 name: hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains phosphorus." [GOC:jl] xref: EC:3.6.1 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016819 name: hydrolase activity, acting on acid anhydrides, in sulfonyl-containing anhydrides namespace: molecular_function def: "Catalysis of the hydrolysis of any acid anhydride which contains a sulfonyl group, -SO2-." [GOC:ai] synonym: "hydrolase activity, acting on acid anhydrides, in sulphonyl-containing anhydrides" EXACT [] xref: EC:3.6.2 is_a: GO:0016817 ! hydrolase activity, acting on acid anhydrides [Term] id: GO:0016821 name: obsolete hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it incorporates process information. synonym: "hydrolase activity, acting on acid anhydrides, involved in cellular and subcellular movement" EXACT [] is_obsolete: true replaced_by: GO:0016817 [Term] id: GO:0016822 name: hydrolase activity, acting on acid carbon-carbon bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond." [GOC:jl] xref: EC:3.7 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016823 name: hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-carbon bond in a ketonic substance, a substance containing a keto (C=O) group." [GOC:ai] xref: EC:3.7.1 is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: GO:0016824 name: hydrolase activity, acting on acid halide bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond." [GOC:jl] xref: EC:3.8 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016825 name: hydrolase activity, acting on acid phosphorus-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid phosphorus-nitrogen bond." [GOC:jl] xref: EC:3.9 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016826 name: hydrolase activity, acting on acid sulfur-nitrogen bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-nitrogen bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-nitrogen bonds" EXACT [] xref: EC:3.10 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016827 name: hydrolase activity, acting on acid carbon-phosphorus bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid carbon-phosphorus bond." [GOC:jl] xref: EC:3.11 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016828 name: hydrolase activity, acting on acid sulfur-sulfur bonds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid sulfur-sulfur bond." [GOC:jl] synonym: "hydrolase activity, acting on acid sulphur-sulphur bonds" EXACT [] xref: EC:3.12 is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0016829 name: lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring." [EC:4.-.-.-, ISBN:0198547684] comment: Note that enzymes of class EC:4.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other lyase activity" NARROW [] xref: EC:4 xref: reactome:R-HSA-5696408 "PHYKPL tetramer hydrolyses 5PHL" xref: reactome:R-HSA-6782895 "TYW1:FMN:4Fe-4S transforms 1-methylguanosine yielding yW-187 (4-demethylwyosine) at nucleotide 37 of tRNA(Phe)" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016830 name: carbon-carbon lyase activity namespace: molecular_function def: "Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] comment: Note that enzymes of class EC:4.1.99.- should also be annotated to this term. synonym: "other carbon-carbon lyase activity" NARROW [] xref: EC:4.1 xref: reactome:R-HSA-389611 "2-hydroxyphytanoyl-CoA => pristanal + formyl-CoA" is_a: GO:0016829 ! lyase activity [Term] id: GO:0016831 name: carboxy-lyase activity namespace: molecular_function def: "Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound." [http://www.mercksource.com/] synonym: "decarboxylase activity" EXACT [] xref: EC:4.1.1 xref: reactome:R-HSA-6787757 "GADL1 decarboxylates acidic AAs" xref: reactome:R-HSA-6814165 "GADL1 decarboxylates CSA to HTAU" xref: reactome:R-HSA-71223 "2-amino-3-carboxymuconate semialdehyde => 2-aminomuconate semialdehyde + CO2" is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016832 name: aldehyde-lyase activity namespace: molecular_function alt_id: GO:0016228 def: "Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone." [http://www.mercksource.com/] synonym: "aldolase activity" BROAD [] xref: EC:4.1.2 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016833 name: oxo-acid-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a C-C bond by other means than by hydrolysis or oxidation, of a 3-hydroxy acid." [EC:4.1.3, GOC:jl] synonym: "oxo-acid lyase activity" EXACT [] synonym: "oxoacid lyase activity" EXACT [] xref: EC:4.1.3 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0016834 name: obsolete other carbon-carbon lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-carbon lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-carbon lyase activity" EXACT [] is_obsolete: true consider: GO:0016830 [Term] id: GO:0016835 name: carbon-oxygen lyase activity namespace: molecular_function def: "Catalysis of the breakage of a carbon-oxygen bond." [EC:4.2.-.-] comment: Note that enzymes of class EC:4.2.99.- should also be annotated to this term. synonym: "other carbon-oxygen lyase activity" NARROW [] xref: EC:4.2 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016836 name: hydro-lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of water." [EC:4.2.1] xref: EC:4.2.1 xref: reactome:R-HSA-9014627 "SDS dimers:PXLP dehydrate L-Thr to 2AA" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016837 name: carbon-oxygen lyase activity, acting on polysaccharides namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by the elimination of an alcohol from a polysaccharide." [EC:4.2.-.-] xref: EC:4.2.2 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016838 name: carbon-oxygen lyase activity, acting on phosphates namespace: molecular_function def: "Catalysis of the cleavage of a carbon-oxygen bond by elimination of a phosphate." [EC:4.2.-.-] xref: EC:4.2.3 is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0016839 name: obsolete other carbon-oxygen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-oxygen bond. Enzymes with this activity are 'miscellaneous' carbon-oxygen lyases that cannot be grouped into one of the specific subclasses of the carbon-oxygen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-oxygen lyase activity" EXACT [] is_obsolete: true consider: GO:0016835 [Term] id: GO:0016840 name: carbon-nitrogen lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia or one of its derivatives, with the formation of a double bond or ring. Enzymes with this activity may catalyze the actual elimination of the ammonia, amine or amide, e.g. CH-CH(-NH-R) = C=CH- + NH2-R. Others, however, catalyze elimination of another component, e.g. water, which is followed by spontaneous reactions that lead to breakage of the C-N bond, e.g. L-serine ammonia-lyase (EC:4.3.1.17), so that the overall reaction is C(-OH)-CH(-NH2) = CH2-CO- + NH3, i.e. an elimination with rearrangement. The sub-subclasses of EC:4.3 are the ammonia-lyases (EC:4.3.1), lyases acting on amides, amidines, etc. (EC:4.3.2), the amine-lyases (EC:4.3.3), and other carbon-nitrogen lyases (EC:4.3.99)." [EC:4.3.-.-] comment: Note that enzymes of class EC:4.3.99.- should also be annotated to this term. synonym: "other carbon-nitrogen lyase activity" NARROW [] xref: EC:4.3 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016841 name: ammonia-lyase activity namespace: molecular_function def: "Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.1 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016842 name: amidine-lyase activity namespace: molecular_function def: "Catalysis of the release of amides or amidines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amide or amidine as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.2 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016843 name: amine-lyase activity namespace: molecular_function def: "Catalysis of the release of amines by the cleavage of a carbon-nitrogen bond or the reverse reaction with an amine as a substrate." [EC:4.3.-.-, GOC:krc] xref: EC:4.3.3 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0016844 name: strictosidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3alpha(S)-strictosidine + H(2)O = secologanin + tryptamine." [EC:4.3.3.2, RHEA:15013] synonym: "3-alpha(S)-strictosidine tryptamine-lyase (secologanin-forming)" EXACT [EC:4.3.3.2] synonym: "3-alpha(S)-strictosidine tryptamine-lyase activity" EXACT [EC:4.3.3.2] synonym: "STR activity" EXACT [EC:4.3.3.2] synonym: "strictosidine synthetase activity" EXACT [EC:4.3.3.2] xref: EC:4.3.3.2 xref: KEGG:R03738 xref: MetaCyc:STRICTOSIDINE-SYNTHASE-RXN xref: RHEA:15013 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0016845 name: obsolete other carbon-nitrogen lyase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a carbon-nitrogen bond. Enzymes with this activity are 'miscellaneous' carbon-nitrogen lyases that cannot be grouped into one of the specific subclasses of the carbon-nitrogen lyases." [GOC:krc] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-nitrogen lyase activity" EXACT [] is_obsolete: true consider: GO:0016840 [Term] id: GO:0016846 name: carbon-sulfur lyase activity namespace: molecular_function def: "Catalysis of the elimination of hydrogen sulfide or substituted H2S." [EC:4.4.-.-] synonym: "carbon-sulphur lyase activity" EXACT [] xref: EC:4.4 xref: reactome:R-HSA-1614567 "Excess homocysteine yields homolanthionine and H2S" is_a: GO:0016829 ! lyase activity [Term] id: GO:0016847 name: 1-aminocyclopropane-1-carboxylate synthase activity namespace: molecular_function alt_id: GO:0034100 def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) = 1-aminocyclopropane-1-carboxylate + S-methyl-5'-thioadenosine + H(+)." [EC:4.4.1.14, RHEA:21744] comment: Note that this function was formerly EC:4.1.99.4. synonym: "1-aminocyclopropane-1-carboxylate synthetase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropane-1-carboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "1-aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "ACC synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylate synthase activity" EXACT [EC:4.4.1.14] synonym: "aminocyclopropanecarboxylic acid synthase activity" EXACT [EC:4.4.1.14] synonym: "L-VG deaminase activity" RELATED [PMID:11470512] synonym: "L-vinylglycine deaminase activity" RELATED [PMID:11470512] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase (1-aminocyclopropane-1-carboxylate-forming)" EXACT [EC:4.4.1.14] synonym: "S-adenosyl-L-methionine methylthioadenosine-lyase activity" EXACT [EC:4.4.1.14] xref: EC:4.4.1.14 xref: KEGG:R00179 xref: MetaCyc:4.4.1.14-RXN xref: RHEA:21744 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0016848 name: carbon-halide lyase activity namespace: molecular_function def: "Catalysis of the breakage of a bond between carbon and any halogen atom." [GOC:mah] xref: EC:4.5 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016849 name: phosphorus-oxygen lyase activity namespace: molecular_function def: "Catalysis of the cleavage of a phosphorus-oxygen bond by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond." [GOC:jl] xref: EC:4.6 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016850 name: obsolete other lyase activity namespace: molecular_function def: "OBSOLETE. A grouping term for lyases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other lyase activity" EXACT [] is_obsolete: true consider: GO:0016829 [Term] id: GO:0016851 name: magnesium chelatase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H(2)O + Mg(2+) + protoporphyrin IX = ADP + 2 H(+) + magnesium protoporphyrin IX + phosphate." [EC:6.6.1.1, RHEA:13961] comment: Note that this was EC:4.99.1.1. synonym: "magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin chelatase activity" EXACT [EC:6.6.1.1] synonym: "magnesium-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-chelatase activity" BROAD [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX chelatase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesio-lyase activity" EXACT [EC:6.6.1.1] synonym: "Mg-protoporphyrin IX magnesium-lyase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX magnesium-chelatase activity" EXACT [EC:6.6.1.1] synonym: "protoporphyrin IX Mg-chelatase activity" EXACT [EC:6.6.1.1] xref: EC:6.6.1.1 xref: KEGG:R03877 xref: MetaCyc:RXN1F-20 xref: RHEA:13961 is_a: GO:0051003 ! ligase activity, forming nitrogen-metal bonds, forming coordination complexes [Term] id: GO:0016852 name: sirohydrochlorin cobaltochelatase activity namespace: molecular_function def: "Catalysis of the reaction: sirohydrochlorin + Co2+ = cobalt-sirohydrochlorin + 2 H+." [EC:4.99.1.3] synonym: "anaerobic cobalt chelatase activity" EXACT [] synonym: "CbiK" NARROW [] synonym: "CbiX" RELATED [EC:4.99.1.3] synonym: "CbiXS" RELATED [EC:4.99.1.3] synonym: "cobalt-sirohydrochlorin cobalt-lyase (sirohydrochlorin-forming)" EXACT [EC:4.99.1.3] synonym: "sirohydrochlorin cobalt-lyase activity" EXACT [EC:4.99.1.3] xref: EC:4.99.1.3 xref: MetaCyc:4.99.1.3-RXN xref: RHEA:15893 is_a: GO:0016829 ! lyase activity [Term] id: GO:0016853 name: isomerase activity namespace: molecular_function def: "Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5." [ISBN:0198506732] comment: Note that enzymes of class EC:5.99.-.- should also be annotated to this term. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_pir subset: goslim_yeast synonym: "other isomerase activity" NARROW [] xref: EC:5 xref: reactome:R-HSA-6787623 "TSTA3 dimer epimerises GDP-DHDMan to GDP-KDGal" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016854 name: racemase and epimerase activity namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule." [GOC:mah, ISBN:0198506732] comment: Note that enzymes of class EC:5.1.99.- should also be annotated to this term. Note that 'epimerase' refers to the conversion of an epimer into its diastereoisomer, and 'racemase' refers to the interconversion of the two enantiomers of a chiral compound. synonym: "racemase and epimerase activity, acting on other compounds" NARROW [] xref: EC:5.1 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016855 name: racemase and epimerase activity, acting on amino acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in an amino acid." [GOC:mah] xref: EC:5.1.1 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016856 name: racemase and epimerase activity, acting on hydroxy acids and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a hydroxy acid molecule." [GOC:mah] xref: EC:5.1.2 is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016857 name: racemase and epimerase activity, acting on carbohydrates and derivatives namespace: molecular_function def: "Catalysis of a reaction that alters the configuration of one or more chiral centers in a carbohydrate molecule." [GOC:mah] xref: EC:5.1.3 xref: reactome:R-HSA-6787677 "FUOM isomerises alpha-Fuc to beta-Fuc" is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0016858 name: obsolete racemase and epimerase activity, acting on other compounds namespace: molecular_function def: "OBSOLETE. Racemase and epimerase activity on compounds other than amino acids, hydroxy acids, carbohydrates or their derivatives." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "racemase and epimerase activity, acting on other compounds" EXACT [] is_obsolete: true consider: GO:0016854 [Term] id: GO:0016859 name: cis-trans isomerase activity namespace: molecular_function def: "Catalysis of a reaction that interconverts cis and trans isomers. Atoms or groups are termed cis or trans to one another when they lie respectively on the same or on opposite sides of a reference plane identifiable as common among stereoisomers." [GOC:mah, ISBN:0198506732] xref: EC:5.2 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016860 name: intramolecular oxidoreductase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, and no oxidized product appears." [EC:5.3.-.-] comment: Note that enzymes of class EC:5.3.99.- should also be annotated to this term. synonym: "intramolecular isomerase activity" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" NARROW [] xref: EC:5.3 xref: reactome:R-HSA-109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016861 name: intramolecular oxidoreductase activity, interconverting aldoses and ketoses namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears." [GOC:jl] synonym: "intramolecular isomerase activity, interconverting aldoses and ketoses" EXACT [] xref: EC:5.3.1 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016862 name: intramolecular oxidoreductase activity, interconverting keto- and enol-groups namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is a keto- or an enol-group, are the same molecule, and no oxidized product appears." [GOC:jl] synonym: "intramolecular isomerase activity, interconverting keto- and enol-groups" EXACT [] xref: EC:5.3.2 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016863 name: intramolecular oxidoreductase activity, transposing C=C bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more carbon-carbon double bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.3, GOC:mah] synonym: "intramolecular isomerase activity, transposing C=C bonds" EXACT [] xref: EC:5.3.3 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016864 name: intramolecular oxidoreductase activity, transposing S-S bonds namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor are the same molecule, one or more sulfur-sulfur bonds in the molecule are rearranged, and no oxidized product appears." [EC:5.3.4, GOC:mah] synonym: "intramolecular isomerase activity, transposing S-S bonds" EXACT [] xref: EC:5.3.4 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0016865 name: obsolete intramolecular oxidoreductase activity, other intramolecular oxidoreductases namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular oxidoreductases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "intramolecular isomerase activity, other intramolecular oxidoreductases" EXACT [] synonym: "intramolecular oxidoreductase activity, other intramolecular oxidoreductases" EXACT [] is_obsolete: true consider: GO:0016860 [Term] id: GO:0016866 name: intramolecular transferase activity namespace: molecular_function def: "Catalysis of the transfer of a functional group from one position to another within a single molecule." [GOC:mah] comment: Note that enzymes of class EC:5.4.99.- should also be annotated to this term. synonym: "intramolecular transferase activity, transferring other groups" NARROW [] synonym: "mutase activity" EXACT [] xref: EC:5.4 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016867 name: intramolecular transferase activity, transferring acyl groups namespace: molecular_function def: "Catalysis of the transfer of an acyl group from one position to another within a single molecule." [GOC:mah] xref: EC:5.4.1 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016868 name: intramolecular transferase activity, phosphotransferases namespace: molecular_function alt_id: GO:0016777 def: "Catalysis of the transfer of a phosphate group from one position to another within a single molecule." [GOC:mah] synonym: "phosphomutase activity" EXACT [] synonym: "phosphotransferase activity, with regeneration of donors, apparently catalyzing intramolecular transfers" EXACT [] xref: EC:5.4.2 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016869 name: intramolecular transferase activity, transferring amino groups namespace: molecular_function def: "Catalysis of the transfer of an amino group from one position to another within a single molecule." [GOC:mah] xref: EC:5.4.3 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0016870 name: obsolete intramolecular transferase activity, transferring other groups namespace: molecular_function def: "OBSOLETE. A grouping term for intramolecular transferases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "intramolecular transferase activity, transferring other groups" EXACT [] is_obsolete: true consider: GO:0016866 [Term] id: GO:0016871 name: cycloartenol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = cycloartenol." [EC:5.4.99.8, RHEA:21308] synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming)" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene cycloartenol-cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-epoxysqualene--cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "2,3-oxidosqualene-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] synonym: "oxidosqualene:cycloartenol cyclase activity" EXACT [PMID:18033581] synonym: "squalene-2,3-epoxide-cycloartenol cyclase activity" EXACT [EC:5.4.99.8] xref: EC:5.4.99.8 xref: KEGG:R03200 xref: MetaCyc:CYCLOARTENOL-SYNTHASE-RXN xref: RHEA:21308 is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0016872 name: intramolecular lyase activity namespace: molecular_function def: "The catalysis of certain rearrangements of a molecule to break or form a ring." [GOC:jl, http://www.mercksource.com/] xref: EC:5.5 is_a: GO:0016853 ! isomerase activity [Term] id: GO:0016873 name: obsolete other isomerase activity namespace: molecular_function def: "OBSOLETE. A grouping term for isomerases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other isomerase activity" EXACT [] is_obsolete: true consider: GO:0016853 [Term] id: GO:0016874 name: ligase activity namespace: molecular_function def: "Catalysis of the joining of two substances, or two groups within a single molecule, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6, GOC:mah] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_metagenomics subset: goslim_mouse subset: goslim_pir subset: goslim_yeast synonym: "synthetase activity" EXACT [GOC:jh2] xref: EC:6 is_a: GO:0003824 ! catalytic activity [Term] id: GO:0016875 name: ligase activity, forming carbon-oxygen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-oxygen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.1, GOC:mah] xref: EC:6.1 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016877 name: ligase activity, forming carbon-sulfur bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2, GOC:mah] synonym: "ligase activity, forming carbon-sulphur bonds" EXACT [] xref: EC:6.2 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016878 name: acid-thiol ligase activity namespace: molecular_function def: "Catalysis of the joining of an acid and a thiol via a carbon-sulfur bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.2.1, GOC:mah] xref: EC:6.2.1 is_a: GO:0016877 ! ligase activity, forming carbon-sulfur bonds [Term] id: GO:0016879 name: ligase activity, forming carbon-nitrogen bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3, GOC:mah] comment: Note that enzymes of class EC:6.3.4.- should also be annotated to this term. synonym: "other carbon-nitrogen ligase activity" NARROW [] xref: EC:6.3 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016880 name: acid-ammonia (or amide) ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to ammonia (NH3) or an amide via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] synonym: "amide synthase activity" EXACT [] xref: EC:6.3.1 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016881 name: acid-amino acid ligase activity namespace: molecular_function def: "Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [GOC:jl, GOC:mah] synonym: "peptide synthase activity" EXACT [] xref: EC:6.3.2 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016882 name: cyclo-ligase activity namespace: molecular_function def: "Catalysis of the joining of two groups within a single molecule via a carbon-nitrogen bond, forming heterocyclic ring, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.3.3.1, EC:6.3.3.2, EC:6.3.3.4, GOC:jl, GOC:mah] xref: EC:6.3.3 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016883 name: obsolete other carbon-nitrogen ligase activity namespace: molecular_function def: "OBSOLETE. A grouping term for carbon-nitrogen ligases that cannot be more accurately categorized." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "other carbon-nitrogen ligase activity" EXACT [] is_obsolete: true consider: GO:0016879 [Term] id: GO:0016884 name: carbon-nitrogen ligase activity, with glutamine as amido-N-donor namespace: molecular_function alt_id: GO:0016003 def: "Catalysis of the transfer of the amide nitrogen of glutamine to a substrate. Usually composed of two subunits or domains, one that first hydrolyzes glutamine, and then transfers the resulting ammonia to the second subunit (or domain), where it acts as a source of nitrogen." [PMID:12360532] comment: Changed definition as requested in https://github.com/geneontology/go-ontology/issues/16422 xref: EC:6.3.5 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0016885 name: ligase activity, forming carbon-carbon bonds namespace: molecular_function def: "Catalysis of the joining of two molecules via a carbon-carbon bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.4, GOC:jl, GOC:mah] xref: EC:6.4 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016886 name: ligase activity, forming phosphoric ester bonds namespace: molecular_function def: "Catalysis of the joining of two molecules, or two groups within a single molecule, via a phosphoric ester bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate." [EC:6.5, GOC:mah] xref: EC:6.5 is_a: GO:0016874 ! ligase activity [Term] id: GO:0016887 name: ATPase activity namespace: molecular_function alt_id: GO:0004002 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate + 2 H+. May or may not be coupled to another reaction." [EC:3.6.1.3, GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "(Ca2+ + Mg2+)-ATPase" NARROW [EC:3.6.1.3] synonym: "adenosine 5'-triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosine triphosphatase activity" EXACT [EC:3.6.1.3] synonym: "adenosinetriphosphatase activity" EXACT [] synonym: "ATP hydrolase activity" EXACT [EC:3.6.1.3] synonym: "ATP monophosphatase activity" EXACT [EC:3.6.1.3] synonym: "ATP phosphohydrolase activity" EXACT [] synonym: "complex V (mitochondrial electron transport)" RELATED [EC:3.6.1.3] synonym: "HCO3--ATPase" NARROW [EC:3.6.1.3] synonym: "SV40 T-antigen" RELATED [EC:3.6.1.3] xref: EC:3.6.1.3 xref: MetaCyc:ADENOSINETRIPHOSPHATASE-RXN xref: reactome:R-HSA-159101 "NXF1:NXT1 (TAP:p15) binds capped mRNA:CBC:EJC:TREX (minus DDX39B)" xref: reactome:R-HSA-416985 "Trafficking of GluR2-containing AMPA receptors to synapse" xref: reactome:R-HSA-5654989 "SPRTN:VCP-mediated release of POLH from monoUb:K164-PCNA" xref: reactome:R-HSA-5694425 "NSF ATPase activity dissociates cis-SNARE" xref: reactome:R-HSA-6809015 "NSF ATPase activity dissociates cis-SNARE at cis-Golgi" xref: reactome:R-HSA-6811422 "NSF ATPase activity dissociates cis-SNARE at the ER" xref: reactome:R-HSA-6814670 "ATP hydrolysis by RHOBTB3 promotes PLIN3 dissociation" xref: reactome:R-HSA-6814678 "ATP hydrolysis by NSF disassembles the cis-SNARE at the TGN" xref: reactome:R-HSA-6814683 "NSF-dependent ATP hydrolysis disassembles the cis-SNARE at the TGN" xref: reactome:R-HSA-72139 "Formation of the active Spliceosomal C (B*) complex" xref: reactome:R-HSA-8847638 "ATP hydrolysis by NSF disassembles the cis-SNARE at the Golgi membrane" xref: reactome:R-HSA-8868658 "HSPA8-mediated ATP hydrolysis promotes vesicle uncoating" xref: reactome:R-HSA-917693 "ESCRT Disassembly" xref: RHEA:13065 is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0016888 name: endodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] synonym: "endodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.21 xref: reactome:R-HSA-912368 "SPO11 hydrolyzes DNA forming double-strand breaks" is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016889 name: endodeoxyribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] synonym: "endodeoxyribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.22 is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016890 name: site-specific endodeoxyribonuclease activity, specific for altered base namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages at specific sites within a deoxyribonucleic acid molecule by creating internal breaks." [GOC:jl] xref: EC:3.1.25 is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0016891 name: endoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:ai] xref: EC:3.1.26 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016893 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016892 name: endoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:ai] synonym: "endoribonuclease activity, producing other than 5'-phosphomonoesters" EXACT [] xref: EC:3.1.27 is_a: GO:0004521 ! endoribonuclease activity is_a: GO:0016894 ! endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016893 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 5'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "5'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters" RELATED [] xref: EC:3.1.30 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016894 name: endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks to yield 3'-phosphomonoesters." [GOC:mah] comment: Note that this activity can catalyze cleavage of DNA or RNA. synonym: "3'-endonuclease activity" EXACT [] synonym: "endoribonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters" RELATED [] xref: EC:3.1.31 is_a: GO:0004519 ! endonuclease activity [Term] id: GO:0016895 name: exodeoxyribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function alt_id: GO:0008858 def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] synonym: "exodeoxyribonuclease activity, producing 5' phosphomonoesters" EXACT [] synonym: "exonuclease VIII activity" NARROW [] xref: EC:3.1.11 is_a: GO:0004529 ! exodeoxyribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016896 name: exoribonuclease activity, producing 5'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 5' phosphomonoesters." [GOC:ai] synonym: "exoribonuclease activity, producing 5' phosphomonoesters" EXACT [] xref: EC:3.1.13 xref: reactome:R-HSA-429860 "DCP1-DCP2 complex decaps mRNA" is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016796 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [Term] id: GO:0016897 name: exoribonuclease activity, producing 3'-phosphomonoesters namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acids by removing nucleotide residues from the 3' or 5' end to yield 3' phosphomonoesters." [GOC:ai] xref: EC:3.1.14 is_a: GO:0004532 ! exoribonuclease activity is_a: GO:0016797 ! exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [Term] id: GO:0016898 name: oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a cytochrome molecule." [GOC:ai] xref: EC:1.1.2 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016899 name: oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an oxygen molecule." [GOC:ai] xref: EC:1.1.3 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016900 name: oxidoreductase activity, acting on the CH-OH group of donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a disulfide molecule." [GOC:ai] synonym: "oxidoreductase activity, acting on the CH-OH group of donors, disulphide as acceptor" EXACT [] xref: EC:1.1.4 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016901 name: oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule." [GOC:ai] xref: EC:1.1.5 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0016902 name: obsolete oxidoreductase activity, acting on the CH-OH group of donors, other acceptors namespace: molecular_function def: "OBSOLETE. Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces an acceptor other than a cytochrome, disulfide, NAD, NADP, oxygen or a quinone or similar compound." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "oxidoreductase activity, acting on the CH-OH group of donors, other acceptors" EXACT [] is_obsolete: true consider: GO:0016614 [Term] id: GO:0016903 name: oxidoreductase activity, acting on the aldehyde or oxo group of donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:ai] comment: Note that enzymes of class EC:1.2.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on the aldehyde or oxo group of donors, other acceptors" NARROW [] xref: EC:1.2 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0016905 name: myosin heavy chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myosin-heavy-chain = ADP + myosin-heavy-chain phosphate." [EC:2.7.11.7] synonym: "ATP:myosin heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "ATP:myosin-heavy-chain O-phosphotransferase activity" EXACT [EC:2.7.11.7] synonym: "calmodulin-dependent myosin heavy chain kinase activity" EXACT [EC:2.7.11.7] synonym: "MHCK" RELATED [EC:2.7.11.7] synonym: "MIHC kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy chain kinase A activity" EXACT [EC:2.7.11.7] synonym: "myosin heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "myosin I heavy chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin I heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin II heavy-chain kinase activity" NARROW [EC:2.7.11.7] synonym: "myosin-heavy-chain kinase activity" EXACT [EC:2.7.11.7] synonym: "STK6" RELATED [EC:2.7.11.7] xref: EC:2.7.11.7 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0016906 name: sterol 3-beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + a sterol = UDP + an O-glucosylsterol." [EC:2.4.1.173] synonym: "sterol 3beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol glucosyltransferase activity" EXACT [] synonym: "sterol-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "sterol:UDPG glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-sterol beta-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "UDP-glucose:sterol glucosyltransferase activity" EXACT [] synonym: "UDPG-SGTase activity" EXACT [EC:2.4.1.173] synonym: "UDPG:sterol glucosyltransferase activity" EXACT [] synonym: "UDPglucose:sterol 3-O-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-poriferasterol glucosyltransferase activity" EXACT [EC:2.4.1.173] synonym: "uridine diphosphoglucose-sterol glucosyltransferase activity" EXACT [EC:2.4.1.173] xref: EC:2.4.1.173 xref: MetaCyc:STEROL-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0016907 name: G protein-coupled acetylcholine receptor activity namespace: molecular_function alt_id: GO:0004981 def: "Combining with acetylcholine and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex." [GOC:bf, GOC:fj, GOC:mah] synonym: "acetylcholine receptor activity, G-protein coupled" EXACT [GOC:bf] synonym: "G protein coupled acetylcholine receptor activity" EXACT [] synonym: "G-protein coupled acetylcholine receptor activity" EXACT [] synonym: "metabotropic acetylcholine receptor activity" EXACT [] synonym: "muscarinic acetylcholine receptor activity" EXACT [] is_a: GO:0008227 ! G protein-coupled amine receptor activity is_a: GO:0015464 ! acetylcholine receptor activity is_a: GO:0099528 ! G protein-coupled neurotransmitter receptor activity [Term] id: GO:0016909 name: SAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. A family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. Strongly activated by stress signals such as heat or osmotic shock, DNA-damaging agents, inhibitors of protein synthesis and pro-inflammatory cytokines." [GOC:ma] synonym: "SAPK" EXACT [] synonym: "stress-activated kinase activity" EXACT [] synonym: "stress-activated protein kinase activity" EXACT [] xref: EC:2.7.11 is_a: GO:0004707 ! MAP kinase activity [Term] id: GO:0016910 name: obsolete SAP kinase 3 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAP kinase 3 activity" EXACT [] synonym: "SAPK3" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016911 name: obsolete SAP kinase 4 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a gene product. synonym: "SAP kinase 4 activity" EXACT [] synonym: "SAPK4" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016912 name: obsolete SAP kinase 5 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there are no known gene products that would be described as 'SAP kinase 5', and the term name implies that it refers to a gene product. synonym: "SAP kinase 5 activity" EXACT [] synonym: "SAPK5" EXACT [] is_obsolete: true consider: GO:0004674 consider: GO:0007254 [Term] id: GO:0016913 name: follicle-stimulating hormone activity namespace: molecular_function def: "The action characteristic of follicle-stimulating hormone (FSH), a gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland. Upon receptor binding, FSH stimulates growth of Graafian follicles in the ovaries in females, and stimulates the epithelium of the seminiferous tubules to increase spermatogenesis." [ISBN:0198547684] synonym: "follicle stimulating hormone activity" EXACT [] synonym: "follitropin activity" EXACT [ISBN:0198506732] synonym: "FSH activity" EXACT [GOC:mah] is_a: GO:0005179 ! hormone activity [Term] id: GO:0016914 name: follicle-stimulating hormone complex namespace: cellular_component def: "A gonadotrophic glycoprotein hormone secreted, in mammals, by the anterior pituitary gland; consists of alpha and beta subunits, the latter of which confers hormonal specificity." [ISBN:0198547684] synonym: "follicle stimulating hormone complex" EXACT [] synonym: "FSH complex" EXACT [] is_a: GO:0061696 ! pituitary gonadotropin complex [Term] id: GO:0016915 name: obsolete activin namespace: molecular_function def: "OBSOLETE. A nonsteroidal regulator, composed of two covalently linked beta subunits, that is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "activin" EXACT [] is_obsolete: true consider: GO:0005160 consider: GO:0046881 [Term] id: GO:0016916 name: obsolete inhibin namespace: molecular_function def: "OBSOLETE. Either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. synonym: "inhibin" EXACT [] is_obsolete: true consider: GO:0005160 consider: GO:0046882 [Term] id: GO:0016917 name: GABA receptor activity namespace: molecular_function def: "Combining with gamma-aminobutyric acid (GABA), and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. (GABA, 4-aminobutyrate) is an amino acid which acts as a neurotransmitter in some organisms." [GOC:jl, GOC:signaling, PMID:10637650] comment: See also the molecular function term 'neurotransmitter receptor activity ; GO:0030594'. synonym: "4-aminobutanoate receptor activity" EXACT [] synonym: "4-aminobutyrate receptor activity" EXACT [] synonym: "GABA binding" EXACT [] synonym: "gamma-aminobutyrate binding" EXACT [] synonym: "gamma-aminobutyric acid binding" EXACT [] synonym: "gamma-aminobutyric acid receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0016918 name: retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinal, one of the forms of vitamin A. Retinal plays an important role in the visual process in most vertebrates, combining with opsins to form visual pigments in the retina." [CHEBI:15035, GOC:curators, ISBN:0198506732] synonym: "blue-sensitive opsin" RELATED [] synonym: "green-sensitive opsin" RELATED [] synonym: "long-wave-sensitive opsin" RELATED [] synonym: "opsin" RELATED [] synonym: "red-sensitive opsin" RELATED [] synonym: "retinaldehyde binding" EXACT [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "UV-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] synonym: "vitamin A binding" BROAD [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0016919 name: obsolete nardilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of polypeptides, preferably at the first bond of Xaa-Arg-Lys, and less commonly at the first bond of Arg-Arg-Xaa, in which Xaa is not Arg or Lys." [EC:3.4.24.61] comment: This term was made obsolete because it represents a gene product. synonym: "N-arginine dibasic convertase activity" EXACT [EC:3.4.24.61] synonym: "nardilysin activity" EXACT [] synonym: "NRD convertase activity" EXACT [EC:3.4.24.61] synonym: "NRD-convertase activity" EXACT [EC:3.4.24.61] xref: EC:3.4.24.61 xref: MetaCyc:3.4.24.61-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0016920 name: pyroglutamyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of the N-terminal pyroglutamyl group from a peptide or protein." [EC:3.4.19.3, EC:3.4.19.6, GOC:mah] xref: EC:3.4.19 is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0016921 name: obsolete pyroglutamyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of the N-terminal pyroglutamyl group from pGlu-His-Xaa tripeptides and pGlu-His-Xaa-Gly tetrapeptides." [EC:3.4.19.6] comment: This term was made obsolete because it represents a gene product. synonym: "PAP-II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamate aminopeptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl aminopeptidase II activity" EXACT [EC:3.4.19.6] synonym: "pyroglutamyl peptidase II" RELATED [EC:3.4.19.6] synonym: "pyroglutamyl-peptidase II activity" EXACT [] synonym: "thyroliberin-hydrolyzing pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyroliberinase activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing factor pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading peptidase activity" EXACT [EC:3.4.19.6] synonym: "thyrotropin-releasing hormone-degrading pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.6] synonym: "TRH-DE activity" NARROW [EC:3.4.19.6] synonym: "TRH-degrading ectoenzyme activity" NARROW [EC:3.4.19.6] synonym: "TRH-specific aminopeptidase activity" NARROW [EC:3.4.19.6] xref: EC:3.4.19.6 xref: MetaCyc:3.4.19.6-RXN is_obsolete: true consider: GO:0008237 consider: GO:0016920 [Term] id: GO:0016922 name: nuclear receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a ligand dependent manner, with a nuclear receptor protein." [GOC:mah, PMID:7776974] synonym: "ligand-dependent nuclear receptor binding" EXACT [] synonym: "ligand-dependent nuclear receptor interactor activity" RELATED [] is_a: GO:0035257 ! nuclear hormone receptor binding [Term] id: GO:0016923 name: obsolete ligand-dependent thyroid hormone receptor interactor activity namespace: molecular_function def: "OBSOLETE. Ligand dependent interaction with the thyroid hormone receptor." [PMID:7776974] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "ligand-dependent thyroid hormone receptor interactor activity" EXACT [] synonym: "TRIP4" RELATED [] is_obsolete: true consider: GO:0046966 [Term] id: GO:0016925 name: protein sumoylation namespace: biological_process alt_id: GO:0006485 alt_id: GO:0016927 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is conjugated to a target protein via an isopeptide bond between the carboxy-terminus of SUMO with an epsilon-amino group of a lysine residue of the target protein." [GOC:jl, PMID:11265250] synonym: "protein sumolation" EXACT [] synonym: "small ubiquitin-related protein 1 conjugation" EXACT [] synonym: "SUMO-protein conjugation" EXACT [] synonym: "sumoylation" EXACT [] xref: Wikipedia:SUMO_protein is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0016926 name: protein desumoylation namespace: biological_process alt_id: GO:0016928 def: "The process in which a SUMO protein (small ubiquitin-related modifier) is cleaved from its target protein." [GOC:jl, PMID:11265250] synonym: "desumoylation" EXACT [] synonym: "protein desumolation" EXACT [] is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0016929 name: SUMO-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within SUMO, or between the SUMO and a larger protein to which it has been conjugated." [GOC:rn, PMID:10094048, PMID:11031248, PMID:11265250] comment: This term should not be used for direct manual annotation because the supporting experiments should always distinguish whether the activity is part of maturation or SUMO removal. subset: gocheck_do_not_manually_annotate synonym: "SUSP" NARROW [] synonym: "ULP" NARROW [] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0016933 name: extracellularly glycine-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular-glycine-gated ion channel activity" EXACT [] synonym: "glycine receptor" BROAD [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0016934 name: extracellularly glycine-gated chloride channel activity namespace: molecular_function alt_id: GO:0004891 def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine is bound by the channel complex or one of its constituent parts on the extracellular side of the plasma membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular-glycine-gated chloride channel activity" EXACT [] synonym: "glycine receptor" BROAD [] synonym: "glycine-inhibited chloride channel activity" RELATED [] xref: reactome:R-HSA-975389 "GLRA:GLRB:Gly transports extracellular Cl- to cytosol" is_a: GO:0005237 ! inhibitory extracellular ligand-gated ion channel activity is_a: GO:0005254 ! chloride channel activity is_a: GO:0016933 ! extracellularly glycine-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0016935 name: glycine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to glycine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0016936 name: galactoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycoside in which the sugar group is galactose." [CHEBI:24163, GOC:jl, ISBN:0198506732] subset: goslim_chembl is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0016937 name: short-branched-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a short branched chain fatty acid residue." [GOC:mah] xref: EC:1.3.99 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0016938 name: kinesin I complex namespace: cellular_component def: "A complex of two kinesin heavy chains and two kinesin light chains." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016939 name: kinesin II complex namespace: cellular_component def: "A complex consisting of two distinct motor subunits that form a heterodimer complexed with a third non-motor accessory subunit, the kinesin associated protein or KAP; the KIF3 heterodimer interacts via its C-terminal portion with KAP, which is thought to regulate the binding of the motor to cargo membranes." [http://www.csfic.mi.cnr.it/centro/lines/8/ric.html] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0016941 name: natriuretic peptide receptor activity namespace: molecular_function def: "Combining with a natriuretic peptide and transmitting the signal to initiate a change in cell activity." [GOC:mah, GOC:signaling] is_a: GO:0001653 ! peptide receptor activity [Term] id: GO:0016942 name: insulin-like growth factor binding protein complex namespace: cellular_component def: "A complex of proteins which includes the insulin-like growth factor (IGF) and a number of IGF-binding proteins. The complex plays a role in growth and development." [GOC:jl] subset: goslim_pir synonym: "IGF binding protein complex" EXACT [] is_a: GO:0036454 ! growth factor complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0016943 name: obsolete RNA polymerase I transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase I following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol I transcription elongation factor activity" EXACT [] synonym: "RNA polymerase I transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006362 [Term] id: GO:0016944 name: obsolete RNA polymerase II transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase II following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol II transcription elongation factor activity" EXACT [] synonym: "RNA polymerase II transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006368 [Term] id: GO:0016945 name: obsolete RNA polymerase III transcription elongation factor activity namespace: molecular_function def: "OBSOLETE. Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule catalyzed by RNA polymerase III following transcription initiation." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "Pol III transcription elongation factor activity" EXACT [] synonym: "RNA polymerase III transcription elongation factor activity" EXACT [] is_obsolete: true consider: GO:0006385 [Term] id: GO:0016946 name: obsolete cathepsin F activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Cleavage of substrates with Phe and Leu in P2." [EC:3.4.22.41] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin F activity" EXACT [] xref: EC:3.4.22.41 xref: MetaCyc:3.4.22.41-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0016962 name: obsolete receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and not a molecular function. synonym: "receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016963 name: obsolete alpha-2 macroglobulin receptor-associated protein activity namespace: molecular_function def: "OBSOLETE. Interaction with the alpha-2 macroglobulin receptor and glycoprotein gp330 forming a complex with the alpha-2 macroglobulin receptor light and heavy chains." [GOC:curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "alpha-2 macroglobulin receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0016964 name: alpha-2 macroglobulin receptor activity namespace: molecular_function def: "Combining with alpha-2 macroglobulin and delivering alpha-2 macroglobulin into the cell via receptor-mediated endocytosis." [GOC:bf, GOC:ma, PMID:6188403] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0016966 name: nitric oxide reductase activity namespace: molecular_function alt_id: GO:0016967 alt_id: GO:0016968 def: "Catalysis of the reaction: H(2)O + 2 ferricytochrome c + nitrous oxide = 2 H(+) + 2 ferrocytochrome c + 2 nitric oxide." [EC:1.7.2.5] synonym: "CYP55" NARROW [] synonym: "cytochrome bc nitric oxide reductase activity" NARROW [] synonym: "nitric-oxide reductase activity" EXACT [EC:1.7.2.5] synonym: "nitrogen oxide reductase activity" EXACT [EC:1.7.2.5] synonym: "nitrous-oxide:(acceptor) oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5] synonym: "nitrous-oxide:acceptor oxidoreductase (NO-forming)" EXACT [EC:1.7.2.5] synonym: "P450 nitric oxide reductase activity" NARROW [] synonym: "P450nor" NARROW [] xref: EC:1.7.2.5 xref: KEGG:R00294 xref: MetaCyc:NITRIC-OXIDE-REDUCTASE-RXN is_a: GO:0016662 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, cytochrome as acceptor [Term] id: GO:0016969 name: obsolete hemerythrin namespace: molecular_function def: "OBSOLETE. An oxygen carrier found in a few groups of invertebrates, e.g. sipunculid worms, certain molluscs, and crustaceans." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemerythrin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016970 name: obsolete hemocyanin namespace: molecular_function def: "OBSOLETE. A blue, copper-containing oxygen carrier present in many molluscs and arthropods." [GOC:ai, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "hemocyanin" EXACT [] is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0016971 name: flavin-linked sulfhydryl oxidase activity namespace: molecular_function def: "Catalysis of the formation of disulfide bridges." [PMID:10899311] is_a: GO:0016972 ! thiol oxidase activity [Term] id: GO:0016972 name: thiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 R'C(R)SH + O2 = 2 R'C(R)S-S(R)CR' + 2 H2O." [EC:1.8.3.2] synonym: "sulfhydryl oxidase activity" EXACT [EC:1.8.3.2] synonym: "thiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.2] xref: EC:1.8.3.2 xref: MetaCyc:THIOL-OXIDASE-RXN xref: RHEA:17357 xref: UM-BBD_reactionID:r1293 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0016973 name: poly(A)+ mRNA export from nucleus namespace: biological_process def: "The directed movement of poly(A)+ mRNA out of the nucleus into the cytoplasm." [GOC:ai] synonym: "poly(A) mRNA export from nucleus" EXACT [] synonym: "poly(A)+ mRNA export from cell nucleus" EXACT [] synonym: "poly(A)+ mRNA export out of nucleus" EXACT [] synonym: "poly(A)+ mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "poly(A)+ mRNA-nucleus export" EXACT [] synonym: "polyadenylated mRNA export from nucleus" RELATED [] is_a: GO:0006406 ! mRNA export from nucleus [Term] id: GO:0016975 name: obsolete alpha-2 macroglobulin namespace: molecular_function def: "OBSOLETE. Inhibition of proteinase by a mechanism involving a bait region which contains specific sites, cleavage of which induces a conformational change that results in trapping of the proteinase; following cleavage in the bait region a thiolester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase; subsequently epsilon-amino groups of the proteinase react with thiolester linkages in the inhibitor to form stable amide links; the entrapped proteinase can now only act on low molecular mass substrates." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-2 macroglobulin" EXACT [] is_obsolete: true replaced_by: GO:0004866 [Term] id: GO:0016977 name: chitosanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of beta-1,4-linkages between N-acetyl-D-glucosamine and D-glucosamine residues in a partly acetylated chitosan." [EC:3.2.1.132] synonym: "chitosan N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.132] xref: EC:3.2.1.132 xref: MetaCyc:3.2.1.132-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016979 name: lipoate-protein ligase activity namespace: molecular_function alt_id: GO:0008916 alt_id: GO:0016978 alt_id: GO:0102315 def: "Catalysis of the lipoylation of a protein in two steps: ATP + (R)-lipoate + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP + diphosphate (overall reaction): (1) ATP + (R)-lipoate = lipoyl-AMP + diphosphate; (2) lipoyl-AMP + a [lipoyl-carrier protein]-L-lysine = a [lipoyl-carrier protein]-N6-(lipoyl)lysine + AMP." [EC:6.3.1.20] synonym: "lipoate-protein ligase A activity" NARROW [] synonym: "lipoate-protein ligase activity (lipoylation of glycine cleavage complex)" NARROW [] synonym: "lipoate-protein ligase B activity" NARROW [] xref: MetaCyc:RXN-13039 xref: MetaCyc:RXN-8654 xref: MetaCyc:RXN-8655 xref: MetaCyc:RXN0-1141 is_a: GO:0016779 ! nucleotidyltransferase activity is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0016980 name: creatinase activity namespace: molecular_function def: "Catalysis of the reaction: creatine + H(2)O = sarcosine + urea." [EC:3.5.3.3, RHEA:22456] synonym: "creatine amidinohydrolase activity" EXACT [EC:3.5.3.3] xref: EC:3.5.3.3 xref: KEGG:R01566 xref: MetaCyc:CREATINASE-RXN xref: RHEA:22456 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016984 name: ribulose-bisphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 1,5-bisphosphate + CO2 + H2O = 2 3-phospho-D-glycerate." [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.39] synonym: "3-phospho-D-glycerate carboxy-lyase (dimerizing; D-ribulose-1,5-bisphosphate-forming)" EXACT [EC:4.1.1.39] synonym: "carboxydismutase activity" RELATED [EC:4.1.1.39] synonym: "D-ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "D-ribulose-1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "diphosphoribulose carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-bisphosphate carboxylase/oxygenase activity" EXACT [] synonym: "ribulose 1,5-diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose 1,5-diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose bisphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase activity" EXACT [EC:4.1.1.39] synonym: "ribulose diphosphate carboxylase/oxygenase activity" EXACT [EC:4.1.1.39] synonym: "RuBisCO activity" EXACT [EC:4.1.1.39] synonym: "rubisco activity" EXACT [] synonym: "RuBP carboxylase activity" EXACT [EC:4.1.1.39] xref: EC:4.1.1.39 xref: MetaCyc:RIBULOSE-BISPHOSPHATE-CARBOXYLASE-RXN xref: RHEA:23124 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0016985 name: mannan endo-1,4-beta-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of (1->4)-beta-D-mannosidic linkages in mannans, galactomannans, glucomannans, and galactoglucomannans." [EC:3.2.1.78] synonym: "1,4-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-1,4-mannan 4-mannanohydrolase activity" EXACT [EC:3.2.1.78] synonym: "beta-D-mannanase activity" EXACT [EC:3.2.1.78] synonym: "beta-mannanase activity" BROAD [EC:3.2.1.78] synonym: "beta-mannanase B" RELATED [EC:3.2.1.78] synonym: "endo-1,4-beta-mannanase activity" EXACT [EC:3.2.1.78] synonym: "endo-1,4-mannanase activity" BROAD [EC:3.2.1.78] synonym: "endo-beta-1,4-mannase activity" EXACT [EC:3.2.1.78] synonym: "endo-beta-mannanase activity" BROAD [EC:3.2.1.78] xref: EC:3.2.1.78 xref: MetaCyc:3.2.1.78-RXN is_a: GO:0004567 ! beta-mannosidase activity [Term] id: GO:0016986 name: obsolete transcription initiation factor activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription initiation." [GOC:curators] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription initiation factor activity" EXACT [] synonym: "transcriptional initiation factor activity" EXACT [] is_obsolete: true consider: GO:0140223 [Term] id: GO:0016987 name: sigma factor activity namespace: molecular_function alt_id: GO:0000996 alt_id: GO:0001053 def: "Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins." [GOC:txnOH-2018] comment: Updated for 2018 transcription branch review see https://github.com/geneontology/go-ontology/issues/15587 and https://github.com/geneontology/go-ontology/issues/14848 synonym: "bacterial sigma factor activity" NARROW [] synonym: "core DNA-dependent RNA polymerase binding promoter specificity activity" EXACT [] synonym: "DNA-dependent RNA polymerase promoter selection factor" EXACT [] synonym: "plastid sigma factor activity" NARROW [] synonym: "promoter selection factor activity" NARROW [] synonym: "sigma factor activity" EXACT [] synonym: "sigma transcription factor" EXACT [] is_a: GO:0140110 ! transcription regulator activity [Term] id: GO:0016988 name: obsolete transcription initiation factor antagonist activity namespace: molecular_function def: "OBSOLETE. The function of binding to a transcription factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl] comment: This term was obsoleted because its definition was vague and apparently broader in scope than the name of the term suggested it was intended to be. synonym: "transcription initiation factor antagonist activity" EXACT [] synonym: "transcriptional initiation factor antagonist activity" EXACT [] is_obsolete: true [Term] id: GO:0016989 name: sigma factor antagonist activity namespace: molecular_function def: "The function of binding to a sigma factor and stopping, preventing or reducing the rate of its transcriptional activity." [GOC:jl, GOC:txnOH, Wikipedia:Anti-sigma_factors] synonym: "anti-sigma factor activity" EXACT [] is_a: GO:0003714 ! transcription corepressor activity [Term] id: GO:0016990 name: arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-citrulline + NH3." [EC:3.5.3.6] synonym: "arginine dihydrolase activity" EXACT [EC:3.5.3.6] synonym: "citrulline iminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine deiminase activity" EXACT [EC:3.5.3.6] synonym: "L-arginine iminohydrolase activity" EXACT [EC:3.5.3.6] xref: EC:3.5.3.6 xref: MetaCyc:ARGININE-DEIMINASE-RXN xref: RHEA:19597 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0016992 name: lipoate synthase activity namespace: molecular_function alt_id: GO:0017140 def: "Catalysis of the reaction: protein N6-(octanoyl)lysine + 2 sulfur + 2 S-adenosyl-L-methionine = protein N6-(lipoyl)lysine + 2 L-methionine + 2 5'-deoxyadenosyl." [EC:2.8.1.8, PMID:18307109] synonym: "LipA" RELATED [EC:2.8.1.8] synonym: "lipoic acid synthase" EXACT [GOC:dph, GOC:tb] synonym: "lipoyl synthase activity" EXACT [EC:2.8.1.8] synonym: "LS" RELATED [EC:2.8.1.8] synonym: "protein 6-N-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] synonym: "protein N6-(octanoyl)lysine:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.8] xref: EC:2.8.1.8 xref: MetaCyc:RXN0-949 xref: reactome:R-HSA-6793591 "LIAS:2(4Fe-4S) transforms octanoyl-K107-GCSH to lipoyl-K107-GCSH" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0016993 name: precorrin-8X methylmutase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-8X = hydrogenobyrinate." [EC:5.4.1.2] synonym: "HBA synthase activity" EXACT [EC:5.4.1.2] synonym: "hydrogenobyrinic acid-binding protein activity" NARROW [EC:5.4.1.2] synonym: "precorrin isomerase activity" EXACT [EC:5.4.1.2] synonym: "precorrin-8X 11,12-methylmutase activity" EXACT [EC:5.4.1.2] xref: EC:5.4.1.2 xref: MetaCyc:5.4.1.2-RXN xref: RHEA:22512 is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0016994 name: precorrin-6A reductase activity namespace: molecular_function def: "Catalysis of the reaction: precorrin-6B + NADP+ = precorrin-6A + NADPH + H+." [EC:1.3.1.54] synonym: "precorrin-6B:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6X reductase activity" EXACT [] synonym: "precorrin-6Y:NADP(+) oxidoreductase activity" EXACT [EC:1.3.1.54] synonym: "precorrin-6Y:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.54] xref: EC:1.3.1.54 xref: MetaCyc:1.3.1.54-RXN xref: RHEA:23408 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0016995 name: cholesterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + O2 = cholest-5-en-3-one + H2O2." [EC:1.1.3.6, RHEA:21328] synonym: "3beta-hydroxy steroid oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "3beta-hydroxysteroid:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol- O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O(2) oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol-O2 oxidoreductase activity" EXACT [EC:1.1.3.6] synonym: "cholesterol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.6] xref: EC:1.1.3.6 xref: KEGG:R01459 xref: MetaCyc:CHOLESTEROL-OXIDASE-RXN xref: RHEA:21328 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0016996 name: endo-alpha-(2,8)-sialidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (2->8)-alpha-sialosyl linkages in oligo- or poly(sialic) acids." [EC:3.2.1.129] synonym: "alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endo-N-acylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endoneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "endosialidase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialoside) alpha-2,8-sialosylhydrolase activity" EXACT [EC:3.2.1.129] synonym: "poly(alpha-2,8-sialosyl) endo-N-acetylneuraminidase activity" EXACT [EC:3.2.1.129] synonym: "polysialoside (2->8)-alpha-sialosylhydrolase activity" EXACT [EC:3.2.1.129] xref: EC:3.2.1.129 xref: MetaCyc:3.2.1.129-RXN is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0016997 name: alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-glycosidic linkages in oligo- or poly(sialic) acids." [GOC:mah] is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0016998 name: cell wall macromolecule catabolic process namespace: biological_process alt_id: GO:0044039 def: "The chemical reactions and pathways resulting in the breakdown of macromolecules that form part of a cell wall." [GOC:go_curators] synonym: "cell wall breakdown" RELATED [GOC:mah] synonym: "cell wall catabolism" RELATED [GOC:mah] synonym: "cell wall degradation" RELATED [GOC:mah] synonym: "cellular cell wall macromolecule breakdown" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule catabolic process" EXACT [] synonym: "cellular cell wall macromolecule catabolism" EXACT [GOC:mah] synonym: "cellular cell wall macromolecule degradation" EXACT [GOC:mah] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0016999 name: antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:cab2] synonym: "antibiotic metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0017000 name: antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] subset: goslim_metagenomics synonym: "antibiotic anabolism" EXACT [] synonym: "antibiotic biosynthesis" EXACT [] synonym: "antibiotic formation" EXACT [] synonym: "antibiotic synthesis" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017001 name: antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms." [GOC:go_curators] synonym: "antibiotic breakdown" EXACT [] synonym: "antibiotic catabolism" EXACT [] synonym: "antibiotic degradation" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017002 name: activin-activated receptor activity namespace: molecular_function def: "Combining with activin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Activin is one of two gonadal glycoproteins related to transforming growth factor beta." [GOC:mah, GOC:signaling, ISBN:0198506732] comment: Note that this term represents an activity and not a gene product, and should only be used when the receptor binds the ligand activin. For binding to other extracellular ligands, consider annotating to terms under 'transmembrane signaling receptor activity ; GO:0004888. synonym: "activin receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0017003 name: protein-heme linkage namespace: biological_process def: "The covalent linkage of heme and a protein." [GOC:ma] synonym: "protein-haem linkage" EXACT [] is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017004 name: cytochrome complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions." [GOC:jl, GOC:mah] subset: goslim_metagenomics synonym: "cytochrome biogenesis" BROAD [] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0017005 name: 3'-tyrosyl-DNA phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 3'-phosphotyrosyl groups formed as covalent intermediates (in DNA backbone breakage) between DNA topoisomerase I and DNA." [PMID:10521354, PMID:16751265] comment: See also the molecular function term 'DNA topoisomerase type I activity ; GO:0003917'. is_a: GO:0070259 ! tyrosyl-DNA phosphodiesterase activity [Term] id: GO:0017006 name: protein-tetrapyrrole linkage namespace: biological_process def: "The covalent linking of a tetrapyrrole to a protein." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017007 name: protein-bilin linkage namespace: biological_process def: "The covalent linkage of bilin and a protein." [GOC:ai] is_a: GO:0017006 ! protein-tetrapyrrole linkage [Term] id: GO:0017008 name: protein-phycobiliviolin linkage namespace: biological_process def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin." [RESID:AA0258] xref: RESID:AA0258 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017009 name: protein-phycocyanobilin linkage namespace: biological_process def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin." [RESID:AA0131] xref: RESID:AA0131 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017010 name: protein-phycourobilin linkage namespace: biological_process def: "The linkage of the chromophore phycourobilin to phycoerythrins." [RESID:AA0260] xref: RESID:AA0260 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017011 name: protein-phycoerythrobilin linkage namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrins." [RESID:AA0132, RESID:AA0259] xref: RESID:AA0132 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017012 name: protein-phytochromobilin linkage namespace: biological_process def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin." [RESID:AA0133] xref: RESID:AA0133 is_a: GO:0017007 ! protein-bilin linkage [Term] id: GO:0017013 name: protein flavinylation namespace: biological_process def: "The addition of a flavin group to a protein amino acid." [GOC:ai] synonym: "protein amino acid flavinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017014 name: protein nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide group to an amino acid within a protein." [GOC:ai, PMID:20972426] synonym: "protein amino acid nitrosylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0017015 name: regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "regulation of transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903844 ! regulation of cellular response to transforming growth factor beta stimulus relationship: regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0017016 name: Ras GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Ras interactor activity" RELATED [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0017017 name: MAP kinase tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: MAP kinase serine/threonine/tyrosine phosphate + H2O = MAP kinase serine/threonine/tyrosine + phosphate." [GOC:mah, PMID:12184814] synonym: "dual-specificity MAP kinase phosphatase activity" EXACT [] is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity is_a: GO:0033549 ! MAP kinase phosphatase activity [Term] id: GO:0017018 name: myosin phosphatase activity namespace: molecular_function alt_id: GO:0017019 def: "Catalysis of the reaction: phosphomyosin + H2O = myosin + phosphate." [EC:3.1.3.16] synonym: "myosin phosphatase myosin binding" RELATED [] synonym: "myosin phosphatase, intrinsic catalyst activity" EXACT [] xref: reactome:R-HSA-390593 "ATP Hydrolysis By Myosin" xref: reactome:R-HSA-445699 "ATP Hydrolysis By Myosin" is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0017020 name: myosin phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme myosin phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "myosin phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0017021 name: obsolete myosin phosphatase myosin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes the binding of myosin phosphatase to myosin, which is not a molecular function. synonym: "myosin phosphatase myosin binding" EXACT [] is_obsolete: true consider: GO:0017018 consider: GO:0017022 [Term] id: GO:0017022 name: myosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a myosin complex; myosins are any of a superfamily of molecular motor proteins that bind to actin and use the energy of ATP hydrolysis to generate force and movement along actin filaments." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] synonym: "myosin phosphatase myosin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017023 name: myosin phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of the phosphate group from phosphomyosin." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex [Term] id: GO:0017024 name: myosin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class I myosin; myosin I heavy chains are single-headed, possess tails of various lengths, and do not self-associate into bipolar filaments." [GOC:bf, GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0017025 name: TBP-class protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a member of the class of TATA-binding proteins (TBP), including any of the TBP-related factors (TRFs)." [GOC:jl, GOC:txnOH, http://www.mblab.gla.ac.uk/, PMID:16858867] synonym: "TATA-binding protein binding" NARROW [] synonym: "TBP binding" NARROW [] synonym: "TBP-related factor (TRF) protein binding" NARROW [] is_a: GO:0140296 ! general transcription initiation factor binding [Term] id: GO:0017026 name: obsolete procollagen C-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the C-terminal propeptide at Ala-Asp in type I and II procollagens and at Arg-Asp in type III." [EC:3.4.24.19] comment: This term was made obsolete because it represents a gene product. synonym: "BMP1" NARROW [] synonym: "carboxyprocollagen peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-endopeptidase activity" EXACT [] synonym: "procollagen C-proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal peptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen C-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxy-terminal proteinase activity" EXACT [EC:3.4.24.19] synonym: "procollagen carboxypeptidase activity" EXACT [EC:3.4.24.19] synonym: "procollagen peptidase activity" EXACT [EC:3.4.24.19] xref: EC:3.4.24.19 xref: MetaCyc:3.4.24.19-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017027 name: obsolete transmembrane receptor protein serine/threonine kinase receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "transmembrane receptor protein serine/threonine kinase receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017028 name: obsolete protein stabilization activity namespace: molecular_function def: "OBSOLETE. Strengthening of a bond between proteins. Proteins are large molecules composed of one or more chains of amino acids. The amino acids are joined in a specific order by peptide bonds." [GOC:jid, http://biotech.icmb.utexas.edu] comment: This term was made obsolete because it represents a biological process. synonym: "protein stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017029 name: obsolete lysosomal protein stabilization namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "lysosomal protein stabilization" EXACT [] is_obsolete: true consider: GO:0005764 consider: GO:0050821 [Term] id: GO:0017030 name: obsolete beta-galactosidase stabilization activity namespace: molecular_function def: "OBSOLETE. Stabilization of the structure of beta-galactosidase." [GOC:ai] comment: This term was made obsolete because it represents a biological process. synonym: "beta-galactosidase stabilization activity" EXACT [] is_obsolete: true replaced_by: GO:0050821 [Term] id: GO:0017032 name: amino acid:potassium symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + K+(out) = amino acid(in) + K+(in)." [GOC:ai] synonym: "potassium:amino acid symporter activity" EXACT [] is_a: GO:0005416 ! amino acid:cation symporter activity is_a: GO:0015079 ! potassium ion transmembrane transporter activity [Term] id: GO:0017034 name: Rap guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rap family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0017038 name: protein import namespace: biological_process def: "The targeting and directed movement of proteins into a cell or organelle. Not all import involves an initial targeting event." [GOC:ai] synonym: "protein uptake" EXACT [] is_a: GO:0015031 ! protein transport [Term] id: GO:0017039 name: obsolete dipeptidyl-peptidase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide from a peptide comprising four or more residues, with broad specificity; also acts on dipeptidyl 2-naphthylamides." [EC:3.4.14.4] comment: This term was made obsolete because it represents a gene product. synonym: "dipeptidyl aminopeptidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl arylamidase III activity" EXACT [EC:3.4.14.4] synonym: "dipeptidyl-peptidase III activity" EXACT [] synonym: "DPP III activity" EXACT [EC:3.4.14.4] synonym: "enkephalinase B activity" NARROW [EC:3.4.14.4] synonym: "red cell angiotensinase activity" NARROW [EC:3.4.14.4] xref: EC:3.4.14.4 xref: MetaCyc:3.4.14.4-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017040 name: N-acylsphingosine amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-acylsphingosine + H2O = a fatty acid + sphingosine." [EC:3.5.1.23] synonym: "acylsphingosine deacylase activity" EXACT [EC:3.5.1.23] synonym: "glycosphingolipid ceramide deacylase" BROAD [EC:3.5.1.23] synonym: "N-acylsphingosine amidohydrolase activity" EXACT [EC:3.5.1.23] xref: EC:3.5.1.23 xref: MetaCyc:CERAMIDASE-RXN xref: reactome:R-HSA-1606583 "Neutral ceramidase hydrolyses ceramide into sphingosine and free fatty acid (plasma membrane)" xref: reactome:R-HSA-1606602 "Acid ceramidase hydrolyses ceramide into sphingosine and free fatty acid (lysosome)" xref: reactome:R-HSA-428205 "ceramide + H2O => stearate + sphingosine [Golgi]" xref: reactome:R-HSA-428231 "ceramide + H2O <=> stearate + sphingosine [endoplasmic reticulum]" xref: RHEA:20856 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017041 name: galactosylgalactosylglucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine + H2O = lactosyl-N-acylsphingosine + D-galactose." [EC:3.2.1.47] synonym: "ceramide trihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexosidase activity" EXACT [EC:3.2.1.47] synonym: "ceramidetrihexoside alpha-galactosidase activity" EXACT [EC:3.2.1.47] synonym: "D-galactosyl-D-galactosyl-D-glucosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.47] synonym: "trihexosyl ceramide galactosidase activity" EXACT [EC:3.2.1.47] synonym: "trihexosylceramide alpha-galactosidase activity" EXACT [EC:3.2.1.47] xref: EC:3.2.1.47 xref: MetaCyc:3.2.1.47-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0017042 name: glycosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: glycosyl-N-acylsphingosine + H2O = a sugar + N-acylsphingosine." [EC:3.2.1.62] synonym: "cerebrosidase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl ceramide glycosylhydrolase activity" EXACT [EC:3.2.1.62] synonym: "glycosyl-N-acylsphingosine glycohydrolase activity" EXACT [EC:3.2.1.62] synonym: "lactase-phlorizin hydrolase" BROAD [EC:3.2.1.62] synonym: "phloretin-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin beta-glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phloridzin glucosidase activity" EXACT [EC:3.2.1.62] synonym: "phlorizin hydrolase activity" EXACT [EC:3.2.1.62] xref: EC:3.2.1.62 xref: MetaCyc:GLYCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0017043 name: obsolete adrenocorticotropin namespace: molecular_function def: "OBSOLETE. A polypeptide hormone which stimulates the adrenal cortex to synthesize and secrete glucocorticoid hormones." [ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "adrenocorticotropin" EXACT [] synonym: "corticotropin" BROAD [] is_obsolete: true consider: GO:0005102 consider: GO:0046886 consider: GO:0046887 [Term] id: GO:0017044 name: melanocyte-stimulating hormone activity namespace: molecular_function def: "The action characteristic of melanocyte-stimulating hormone, any of three peptide hormones that are produced by the intermediate lobe of the pituitary gland and, upon receptor binding, cause dispersal of melanosomes in melanophores of poikilothermic vertebrates." [ISBN:0198506732] synonym: "alpha-melanocyte stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "alpha-melanophore stimulating hormone activity" NARROW [ISBN:0198506732] synonym: "melanocyte stimulating hormone activity" EXACT [] is_a: GO:0005179 ! hormone activity [Term] id: GO:0017045 name: corticotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of corticotropin-releasing hormone (CRH), any of a number of peptides released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, CRH increases the rate of corticotropin secretion by the anterior pituitary." [ISBN:0198506732] synonym: "adrenocorticotropin-releasing hormone" EXACT [] xref: Wikipedia:Corticotropin-releasing_hormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0017046 name: peptide hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with any peptide with hormonal activity in animals." [GOC:jl, ISBN:0198506732] synonym: "polypeptide hormone binding" EXACT [] is_a: GO:0042277 ! peptide binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0017048 name: Rho GTPase binding namespace: molecular_function alt_id: GO:0017031 def: "Interacting selectively and non-covalently with Rho protein, any member of the Rho subfamily of the Ras superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [ISBN:0198547684, PMID:12581856] synonym: "Rho interactor activity" RELATED [] synonym: "Rhophilin" NARROW [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017049 name: GTP-Rho binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTP-bound form of the Rho protein." [GOC:mah] is_a: GO:0017048 ! Rho GTPase binding [Term] id: GO:0017050 name: D-erythro-sphingosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: sphingosine + ATP = sphingosine 1-phosphate + ADP." [MetaCyc:RXN3DJ-11417] synonym: "sphingosine kinase activity" EXACT [] xref: MetaCyc:RXN3DJ-11417 xref: reactome:R-HSA-428273 "sphingosine +ATP => sphingosine 1-phosphate + ADP" xref: reactome:R-HSA-5218845 "p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate" is_a: GO:0016301 ! kinase activity [Term] id: GO:0017051 name: retinol dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + retinol = adenosine 3',5'-bisphosphate + anhydroretinol." [PMID:9857081] is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0017052 name: obsolete insulin-like growth factor binding protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "insulin-like growth factor binding protein" EXACT [] is_obsolete: true consider: GO:0016942 [Term] id: GO:0017053 name: transcriptional repressor complex namespace: cellular_component def: "A protein complex that possesses activity that prevents or downregulates transcription." [GOC:mah] subset: goslim_pir synonym: "transcription factor inhibitor complex" EXACT [GOC:bhm] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0017054 name: negative cofactor 2 complex namespace: cellular_component def: "A heterodimeric protein complex that can stably associate with TATA-binding protein on promoters, thereby preventing the assembly of transcription factors TFIIA and TFIIB and leading to repression of RNA polymerase II transcription. The two subunits, NC2alpha (Drap1) and NC2beta (Dr1), dimerize through histone fold domains of the H2A/H2B type present in the amino termini." [PMID:15574413] is_a: GO:0090571 ! RNA polymerase II transcription repressor complex [Term] id: GO:0017055 name: negative regulation of RNA polymerase II transcriptional preinitiation complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA polymerase II transcriptional preinitiation complex assembly." [GOC:go_curators] synonym: "down regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "down-regulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "downregulation of RNA polymerase II transcriptional preinitiation complex assembly" EXACT [] synonym: "inhibition of RNA polymerase II transcriptional preinitiation complex assembly" NARROW [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex assembly" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional pre-initiation complex biosynthesis" EXACT [] synonym: "negative regulation of RNA polymerase II transcriptional preinitiation complex formation" EXACT [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0045898 ! regulation of RNA polymerase II transcriptional preinitiation complex assembly is_a: GO:0060633 ! negative regulation of transcription initiation from RNA polymerase II promoter relationship: negatively_regulates GO:0051123 ! RNA polymerase II preinitiation complex assembly [Term] id: GO:0017056 name: structural constituent of nuclear pore namespace: molecular_function alt_id: GO:0005487 def: "The action of a molecule that contributes to the structural integrity of the nuclear pore complex, a protein-lined channel in the nuclear envelope that allows the transfer of macromolecules." [GOC:mah, PMID:25802992] comment: Note that this term is meant to be used for nuclear pore proteins. For importins and exportins, consider 'nuclear import signal receptor activity' or 'nuclear export signal receptor activity', respectively. synonym: "nuclear pore activity" RELATED [] synonym: "nucleocytoplasmic transporter activity" EXACT [] xref: reactome:R-HSA-1176059 "Translocation of Influenza A virus nonstructural protein 1 (NS1A) into the nucleus" xref: reactome:R-HSA-170796 "NPC transports GCK1:GKRP from cytosol to nucleoplasm" xref: reactome:R-HSA-192627 "Viral mRNA Export" xref: reactome:R-HSA-192925 "Export of Spliced Viral mRNA" xref: reactome:R-HSA-5252041 "NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm" xref: reactome:R-HSA-5578744 "Importin-8 imports AGO2:miRNA into the nucleus" xref: reactome:R-HSA-6783483 "tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol" xref: reactome:R-HSA-75097 "Transport of the export-competent mRNP complex through the NPC" is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0017057 name: 6-phosphogluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: 6-O-phosphono-D-glucono-1,5-lactone + H(2)O = 6-phospho-D-gluconate + H(+)." [EC:3.1.1.31, RHEA:12556] synonym: "6-PGL" RELATED [EC:3.1.1.31] synonym: "6-phospho-D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.31] synonym: "phosphogluconolactonase activity" EXACT [EC:3.1.1.31] xref: EC:3.1.1.31 xref: KEGG:R02035 xref: MetaCyc:6PGLUCONOLACT-RXN xref: reactome:R-HSA-71296 "D-glucono-1,5-lactone 6-phosphate + H2O => 6-phospho-D-gluconate" xref: RHEA:12556 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0017058 name: FH1 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a FH1 domain of a protein, a proline-rich domain, usually located in front of a FH2 domain." [GOC:go_curators] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017059 name: serine C-palmitoyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a palmitoyl on to serine, forming 3-dehydro-D-sphinganine." [EC:2.3.1.50] is_a: GO:0031211 ! endoplasmic reticulum palmitoyltransferase complex [Term] id: GO:0017060 name: 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-(1,3)-N-acetyl-D-glucosaminyl-R = GDP + beta-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.65] synonym: "(Le(a))-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "(Lea)-dependent (alpha-3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "3-alpha-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "alpha(1,4)-L-fucosyltransferase activity" BROAD [] synonym: "alpha-(1,3/1,4) fucosyltransferase III activity" BROAD [EC:2.4.1.65] synonym: "alpha-(1,4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "alpha-(1->4)-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "alpha-4-L-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "beta-acetylglucosaminylsaccharide fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood group Lewis alpha-4-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood-group substance Le(a)-dependent fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "blood-group substance Lea-dependent fucosyltransferase" BROAD [EC:2.4.1.65] synonym: "FucT-II activity" BROAD [EC:2.4.1.65] synonym: "galactoside 3(4)-L-fucosyltransferase activity" BROAD [] synonym: "GDP-beta-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "GDP-L-fucose:3-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 4I-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-beta-acetylglucosaminylsaccharide 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "guanosine diphosphofucose-glycoprotein 4-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.65] synonym: "Lewis alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1,3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis blood group alpha-(1->3/4)-fucosyltransferase activity" BROAD [EC:2.4.1.65] synonym: "Lewis FT activity" BROAD [EC:2.4.1.65] synonym: "Lewis(Le) blood group gene-dependent alpha-(1,3/4)-L-fucosyltransferase activity" BROAD [] synonym: "Lewis(Le) blood group gene-dependent alpha-(1->3/4)-L-fucosyltransferase activity" NARROW [EC:2.4.1.65] xref: EC:2.4.1.65 xref: MetaCyc:2.4.1.65-RXN xref: reactome:R-HSA-5693925 "FUT3 transfers L-fucose to Gal1,3GlcNAc" xref: RHEA:23628 is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0017061 name: S-methyl-5-thioadenosine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-methylthioadenosine + phosphate = adenine + 5-methylthio-D-ribose 1-phosphate." [EC:2.4.2.28] synonym: "5'-deoxy-5'-methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "5'-methylthioadenosine phosphorylase activity" EXACT [] synonym: "5'-methylthioadenosine:phosphate methylthio-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MeSAdo/Ado phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine nucleoside phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "methylthioadenosine phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTA phosphorylase activity" EXACT [EC:2.4.2.28] synonym: "MTAPase activity" EXACT [EC:2.4.2.28] synonym: "S-methyl-5-thioadenosine:phosphate S-methyl-5-thio-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.28] xref: EC:2.4.2.28 xref: MetaCyc:5-METHYLTHIOADENOSINE-PHOSPHORYLASE-RXN xref: reactome:R-HSA-1237160 "MTA is cleaved and phosphorylated" is_a: GO:0004731 ! purine-nucleoside phosphorylase activity [Term] id: GO:0017062 name: respiratory chain complex III assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the cytochrome bc(1) complex, a transmembrane lipoprotein complex that it catalyzes the reduction of cytochrome c by accepting reducing equivalents from Coenzyme Q, by the aggregation, arrangement and bonding together of its constituents." [GOC:jl, http://www.brainyencyclopedia.com/] synonym: "coenzyme Q and cytochrome c reductase complex assembly" EXACT [] synonym: "coenzyme Q and cytochrome c reductase complex biogenesis" EXACT [] synonym: "complex III assembly" EXACT [] synonym: "complex III biogenesis" EXACT [] synonym: "cytochrome bc(1) complex assembly" EXACT [GOC:mcc] synonym: "cytochrome bc(1) complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0017063 name: obsolete phosphatidylserine-specific phospholipase A1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.32] comment: This term was made obsolete because the definition does not match the term name. synonym: "phosphatidylserine-specific phospholipase A1 activity" EXACT [] is_obsolete: true consider: GO:0052739 consider: GO:0052740 [Term] id: GO:0017064 name: fatty acid amide hydrolase activity namespace: molecular_function alt_id: GO:0017073 def: "Catalysis of the hydrolysis of a fatty acid amide to yield a fatty acid." [PMID:15952893] xref: reactome:R-HSA-5693742 "FAAH hydrolyses AEA to AA and ETA" xref: reactome:R-HSA-5693751 "FAAH2 hydrolyses AEA to AA and ETA" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017065 name: single-strand selective uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases present in single-stranded DNA." [GOC:elh, PMID:9224623] synonym: "single-strand selective monofunctional uracil-DNA glycosylase activity" EXACT [] xref: reactome:R-HSA-110221 "Cleavage of uracil by SMUG1 glycosylase" is_a: GO:0004844 ! uracil DNA N-glycosylase activity [Term] id: GO:0017067 name: tyrosine-ester sulfotransferase activity namespace: molecular_function alt_id: GO:0008128 def: "Catalysis of the reaction: 3'-phospho-5'-adenylyl sulfate + L-tyrosine methyl ester = L-tyrosine methyl ester 4-sulfate + adenosine 3',5'-diphosphate + H(+)." [EC:2.8.2.9, RHEA:19977] synonym: "3'-phosphoadenylyl-sulfate:L-tyrosine-methyl-ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "aryl sulfotransferase IV" RELATED [EC:2.8.2.9] synonym: "L-tyrosine methyl ester sulfotransferase activity" EXACT [EC:2.8.2.9] synonym: "tyrosine-ester sulphotransferase activity" EXACT [] xref: EC:2.8.2.9 xref: KEGG:R04213 xref: MetaCyc:TYROSINE-ESTER-SULFOTRANSFERASE-RXN xref: RHEA:19977 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0017069 name: snRNA binding namespace: molecular_function alt_id: GO:0000945 def: "Interacting selectively and non-covalently with a small nuclear RNA (snRNA)." [GOC:mah] synonym: "base pairing with snRNA" NARROW [] synonym: "small nuclear RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017070 name: U6 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0017071 name: intracellular cyclic nucleotide activated cation channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which cations ions may pass in response to an intracellular cyclic nucleotide binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034703 ! cation channel complex [Term] id: GO:0017072 name: obsolete tubulin-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of tubulin-containing structures in vivo, but is not a component of the assembled structures when performing its normal biological function." [GOC:jl, PMID:11847227] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "tubulin-specific chaperone activity" EXACT [] is_obsolete: true consider: GO:0007021 [Term] id: GO:0017074 name: obsolete procollagen N-endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the N-propeptide of collagen chain alpha-1(I) at Pro-Gln and of alpha-1(II) and alpha-2(I) chains at Ala-Gln." [EC:3.4.24.14] comment: This term was made obsolete because it represents a gene product. synonym: "aminoprocollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "aminoterminal procollagen peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminopeptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen aminoterminal protease activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-endopeptidase activity" EXACT [] synonym: "procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal peptidase activity" EXACT [EC:3.4.24.14] synonym: "procollagen N-terminal proteinase activity" EXACT [EC:3.4.24.14] synonym: "type I/II procollagen N-proteinase activity" EXACT [EC:3.4.24.14] synonym: "type III procollagen" RELATED [EC:3.4.24.14] xref: EC:3.4.24.14 xref: MetaCyc:3.4.24.14-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0017075 name: syntaxin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-1." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0017076 name: purine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with purine nucleotides, any compound consisting of a purine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0017077 name: oxidative phosphorylation uncoupler activity namespace: molecular_function alt_id: GO:0015302 def: "Enables the transfer of protons from mitochondrial intermembrane space into mitochondrial matrix, dissipating the proton gradient across the mitochondrial inner membrane established by the electron transport chain during the oxidative phosphorylation (proton leak). Proton leak uncouples the processes of electron transport/proton generation and ATP synthesis." [PMID:15738989, PMID:16179945] synonym: "mitochondrial uncoupling protein activity" NARROW [] synonym: "uncoupling protein activity" NARROW [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0017078 name: obsolete Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Binds to and modulates the activity of the molecular chaperone Hsc70." [GOC:jl, PMID:11121403] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70 protein activity'. synonym: "Hsc70 interacting protein" BROAD [] synonym: "Hsc70 protein regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0031072 consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0017080 name: sodium channel regulator activity namespace: molecular_function def: "Modulates the activity of a sodium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0017081 name: chloride channel regulator activity namespace: molecular_function def: "Modulates the activity of a chloride channel." [GOC:mah] xref: reactome:R-HSA-383190 "HCO3- transport through ion channel" is_a: GO:0016247 ! channel regulator activity [Term] id: GO:0017082 name: obsolete mineralocorticoid receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a mineralocorticoid and transmitting the signal to the transcriptional machinery by interacting selectively and non-covalently with a specific DNA sequence in order to modulate transcription by RNA polymerase II." [GOC:signaling, PMID:20932876] comment: This term was obsoleted because it represents a gene product, see https://github.com/geneontology/go-ontology/issues/16733 synonym: "aldosterone receptor" NARROW [] is_obsolete: true [Term] id: GO:0017083 name: 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-beta-L-fucose + beta-D-galactosyl-(1,4)-N-acetyl-D-glucosaminyl-R = GDP + 1,4-beta-D-galactosyl-(1,4)-[alpha-L-fucosyl-(1,4)]-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.152] synonym: "galactoside 3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "galactoside 3-L-fucosyltransferase activity" EXACT [] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-beta-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "GDP-L-fucose:1,4-beta-D-galactosyl-N-acetyl-D-glucosaminyl-R 3-L-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "guanosine diphosphofucose-glucoside alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "Lewis-negative alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] synonym: "lewis-negative alpha-3-fucosyltransferase activity" EXACT [EC:2.4.1.152] synonym: "plasma alpha-3-fucosyltransferase activity" NARROW [EC:2.4.1.152] xref: EC:2.4.1.152 xref: MetaCyc:GALACTOSIDE-3-FUCOSYLTRANSFERASE-RXN is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity [Term] id: GO:0017084 name: delta1-pyrroline-5-carboxylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + ATP + NADPH = ADP + L-glutamate gamma-semialdehyde + NADP+ + phosphate." [MetaCyc:PROLINE-MULTI] synonym: "D1-pyrroline-5-carboxylate synthetase activity" EXACT [] xref: reactome:R-HSA-508040 "glutamate + ATP + NADPH + H+ => L-glutamate gamma-semialdehyde + NADP+ + ADP + orthophosphate [P5CS]" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0017085 name: response to insecticide namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insecticide stimulus. Insecticides are chemicals used to kill insects." [GOC:curators] synonym: "insecticide resistance" RELATED [] synonym: "insecticide susceptibility/resistance" RELATED [] is_a: GO:0009636 ! response to toxic substance [Term] id: GO:0017086 name: 3-methyl-2-oxobutanoate dehydrogenase (lipoamide) complex namespace: cellular_component alt_id: GO:0031212 def: "A protein complex that catalyzes the reaction 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)-dihydrolipoamide + carbon dioxide (CO2). This requires thiamine diphosphate; the enzyme also acts on (S)-3-methyl-2-oxopentanoate and 4-methyl-2-oxo-pentanoate." [EC:1.2.4.4] synonym: "BCADH" EXACT [] synonym: "branched-chain alpha-ketoacid dehydrogenase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0017087 name: mitochondrial processing peptidase complex namespace: cellular_component def: "A protein complex that consists of a catalytic alpha subunit (alpha-MPP) and a regulatory beta subunit (beta-MPP), and catalyzes the release of N-terminal targeting peptides from precursor proteins imported into the mitochondrion." [BRENDA:3.4.24.64, EC:3.4.24.64, GOC:mah] comment: Note that monomeric mitochondrial processing peptidases have been observed. is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017088 name: obsolete X-Pro dipeptidyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the terminal bond of Xaa-Pro-Xaa motifs to release unblocked, N-terminal dipeptides from substrates including Ala-Pro-para-nitroanilide and (sequentially, at the second, fourth and sixth bonds) of the motif Tyr-Pro-Phe-Pro-Gly-Pro-Ile." [EC:3.4.14.11] comment: This term was made obsolete because it represents a gene product. synonym: "PepX" RELATED [EC:3.4.14.11] synonym: "X-Pro dipeptidyl-peptidase activity" EXACT [] synonym: "X-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.11] synonym: "X-prolyl dipeptidyl peptidase activity" EXACT [EC:3.4.14.11] synonym: "Xaa-Pro dipeptidyl-peptidase activity" EXACT [] xref: EC:3.4.14.11 xref: MetaCyc:3.4.14.11-RXN is_obsolete: true replaced_by: GO:0008239 [Term] id: GO:0017089 name: glycolipid transporter activity namespace: molecular_function def: "Enables the directed movement of glycolipids, compounds containing (usually) 1-4 linked monosaccharide residues joined by a glycosyl linkage to a lipid, into, out of or within a cell, or between cells." [GOC:ai] xref: reactome:R-HSA-5340320 "GLTP transports GSL from plasma membrane to ER membrane" is_a: GO:0005215 ! transporter activity [Term] id: GO:0017090 name: meprin A complex namespace: cellular_component def: "A protein complex that is located in the cell membrane, and is involved in the metabolism of peptides, including neuropeptides. The complex has metalloendopeptidase activity that catalyzes the hydrolysis of protein and peptide substrates, preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18, GOC:mah, MEROPS_fam:M12] synonym: "PABA peptide hydrolase complex" EXACT [] is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0016021 ! integral component of membrane [Term] id: GO:0017091 name: AU-rich element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of RNA containing frequent adenine and uridine bases." [GOC:bf, GOC:mah, PMID:7892223, PMID:8578590] synonym: "Adenylate/uridylate-rich element binding" EXACT [PMID:8578590] synonym: "ARE binding" EXACT [] synonym: "AU-specific RNA binding" EXACT [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0017092 name: obsolete sterol regulatory element-binding protein site 2 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage, within the membrane-spanning helix, of the amino-terminal half (the intermediate form) of sterol regulatory element binding protein (SREBP). This activity releases the transcription factor domain of SREBP from the membrane, freeing it to enter the nucleus." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 2 protease activity" EXACT [] synonym: "sterol regulatory element-binding protein site 2 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008237 [Term] id: GO:0017093 name: obsolete sterol regulatory element-binding protein protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds within a sterol regulatory element binding protein (SREBP). SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP protease activity" EXACT [] synonym: "sterol regulatory element-binding protein protease activity" EXACT [] is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0017094 name: obsolete sterol regulatory element-binding protein site 1 protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Leu-Ser bond within the luminal loop of a sterol regulatory element binding protein (SREBP). This activity is the first of two sequential cleavage reactions and cleaves SREBP into two membrane-bound halves." [GOC:bf, PMID:12923525] comment: This term was made obsolete because it represents a gene product. synonym: "SREBP site 1 protease activity" EXACT [] synonym: "sterol regulatory element-binding protein site 1 protease activity" EXACT [] is_obsolete: true replaced_by: GO:0008236 [Term] id: GO:0017095 name: heparan sulfate 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 6-O-sulfate; results in 6-O-sulfation of glucosamine residues in heparan sulfate." [PMID:8631808] synonym: "heparan sulphate 6-O-sulphotransferase activity" EXACT [] synonym: "heparin 6-O-sulfotransferase activity" RELATED [] xref: EC:2.8.2 xref: reactome:R-HSA-2076419 "HS6STs sulfate GlcN at C6 in heparan sulfate/heparin" is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0017096 name: acetylserotonin O-methyltransferase activity namespace: molecular_function alt_id: GO:0017097 def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-acetylserotonin = S-adenosyl-L-homocysteine + melatonin. Melatonin is also known as N-acetyl-5-methoxytryptamine." [EC:2.1.1.4] synonym: "acetylserotonin methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "acetylserotonin N-methyltransferase activity" RELATED [KEGG:2.1.1.4] synonym: "hydroxyindole methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "hydroxyindole O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] synonym: "S-adenosyl-L-methionine:N-acetylserotonin O-methyltransferase activity" EXACT [EC:2.1.1.4] xref: EC:2.1.1.4 xref: MetaCyc:ACETYLSEROTONIN-O-METHYLTRANSFERASE-RXN xref: RHEA:15573 is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017098 name: sulfonylurea receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sulfonylurea receptor, a regulatory subunit of the ATP-sensitive potassium ion channel." [GOC:ceb, PMID:11938023] synonym: "sulfonylurea receptor ligand" NARROW [] synonym: "sulphonylurea receptor binding" EXACT [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0017099 name: very-long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor, where the acyl group is a very long chain fatty acid residue. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, GOC:mah] synonym: "very long-chain-acyl-CoA dehydrogenase activity" EXACT [] xref: EC:1.3.99 xref: reactome:R-HSA-548831 "TECR,TECRL dehydrogenate TOD-CoA to ST-CoA" is_a: GO:0004466 ! long-chain-acyl-CoA dehydrogenase activity [Term] id: GO:0017101 name: aminoacyl-tRNA synthetase multienzyme complex namespace: cellular_component def: "A multienzyme complex found in all multicellular eukaryotes composed of eight proteins with aminoacyl-tRNA synthetase activities (abbreviated as: ArgRS, AspRS, GluProRS, GlnRS, IleRS, LeuRS, LysRS, MetRS where RS is the enzyme, preceded by the amino acid it uses as a substrate) as well as three non-synthetase proteins (p43, p38, and p18) with diverse functions. Several of these subunits are known dimers, so the total polypeptide count in the multisynthetase complex is at least fifteen. All of the enzymes in this assembly catalyze the same reaction, the covalent attachment of an amino acid to either the 2'- or 3'-hydroxyl of the 3'-terminal adenosine of tRNA, but using different substrates." [GOC:jl, PMID:16169847] synonym: "aminoacyl-tRNA synthetase complex" EXACT [] synonym: "multisynthetase complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0017102 name: methionyl glutamyl tRNA synthetase complex namespace: cellular_component def: "A complex consisting of methionyl- and glutamyl-tRNA synthetases. The tRNA synthetases present in the complex bind to their cognate tRNAs more efficiently than they do as monomers." [GOC:mcc, PMID:11069915] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0017103 name: UTP:galactose-1-phosphate uridylyltransferase activity namespace: molecular_function alt_id: GO:0003982 def: "Catalysis of the reaction: alpha-D-galactose 1-phosphate + UTP = diphosphate + UDP-D-galactose." [EC:2.7.7.10, RHEA:14209] synonym: "alpha-D-galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "galactose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose 1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.10] synonym: "UDPgalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphate galactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "uridine diphosphogalactose pyrophosphorylase activity" EXACT [EC:2.7.7.10] synonym: "UTP-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:alpha-D-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.10] synonym: "UTP:hexose-1-phosphate uridylyltransferase activity" BROAD [] xref: EC:2.7.7.10 xref: KEGG:R00502 xref: MetaCyc:UTPHEXPURIDYLYLTRANS-RXN xref: RHEA:14209 is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0017105 name: acyl-CoA delta11-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + reduced acceptor + O2 = delta11-acyl-CoA + acceptor + 2 H2O." [EC:1.14.19.5] synonym: "acyl-CoA D11-desaturase activity" EXACT [] synonym: "acyl-CoA delta(11)-desaturase activity" EXACT [] xref: EC:1.14.19.5 is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0017106 name: obsolete activin inhibitor activity namespace: molecular_function def: "OBSOLETE. Acts to negatively regulate the activity of activin, a nonsteroidal regulator synthesized in the pituitary gland and gonads that stimulates the secretion of follicle-stimulating hormone." [ISBN:0198506732, ISBN:0721662544] comment: This term was made obsolete because it refers to an obsolete molecular function term, 'activin'. synonym: "activin inhibitor activity" EXACT [] is_obsolete: true consider: GO:0098772 [Term] id: GO:0017107 name: obsolete anion exchanger adaptor activity namespace: molecular_function def: "OBSOLETE. The binding activity of a molecule that brings together an anion exchanger and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] comment: The term was made obsolete because it referred to an interaction of an anion transporter with the AP1 adaptor by which it is probably transported, see: PMID:22744004; PMID:20833140; ie the adaptor does not specifically target an anion adaptor. is_obsolete: true [Term] id: GO:0017108 name: 5'-flap endonuclease activity namespace: molecular_function def: "Catalysis of the cleavage of a 5' flap structure in DNA, but not other DNA structures; processes the 5' ends of Okazaki fragments in lagging strand DNA synthesis." [PMID:9778254] synonym: "5' flap endonuclease activity" EXACT [] xref: reactome:R-HSA-110363 "FEN1 bound to PCNA and APEX1 cleaves flap ssDNA" xref: reactome:R-HSA-174446 "Removal of remaining Flap from the C-strand" xref: reactome:R-HSA-5651782 "FEN1 bound to POLB cleaves displaced DNA strand (flap)" xref: reactome:R-HSA-5687664 "FEN1 cleaves displaced ssDNA flaps during MMEJ" xref: reactome:R-HSA-69152 "Removal of remaining Flap" is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters is_a: GO:0048256 ! flap endonuclease activity [Term] id: GO:0017109 name: glutamate-cysteine ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate to cysteine, forming glutamylcysteine." [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0017110 name: nucleoside-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside diphosphate + H2O = a nucleotide + phosphate." [EC:3.6.1.6] synonym: "apyrase activity" BROAD [] synonym: "IDPase" NARROW [EC:3.6.1.6] synonym: "inosine 5'-diphosphatase" NARROW [EC:3.6.1.6] synonym: "inosine diphosphatase" NARROW [EC:3.6.1.6] synonym: "NDPase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphatase activity" EXACT [] synonym: "nucleoside diphosphate phosphatase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "nucleoside-diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.6] synonym: "type B nucleoside diphosphatase" NARROW [EC:3.6.1.6] synonym: "type L nucleoside diphosphatase" NARROW [EC:3.6.1.6] xref: EC:3.6.1.6 xref: MetaCyc:NUCLEOSIDE-DIPHOSPHATASE-RXN xref: reactome:R-HSA-2395876 "NUDT15 hydrolyses 8-oxo-dGDP to 8-oxo-dGMP" xref: reactome:R-HSA-8850854 "NTPDase1 hydrolyzes nucleoside diphosphates" xref: reactome:R-HSA-8851129 "NTPDase3 hydrolyzes nucleoside diphosphates" xref: reactome:R-HSA-8851225 "NTPDase4 hydrolyzes nucleoside diphosphates" xref: reactome:R-HSA-8851356 "NTPDase5 hydrolyzes nucleoside diphosphates" xref: reactome:R-HSA-8851396 "NTPDase6 hydrolyzes nucleoside diphosphates" xref: reactome:R-HSA-8851550 "NTPDase8 hydrolyzes nucleoside diphosphates" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017111 name: nucleoside-triphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside triphosphate + H2O = nucleoside diphosphate + phosphate." [EC:3.6.1.15] subset: goslim_chembl subset: goslim_metagenomics synonym: "apyrase activity" BROAD [] synonym: "NTPase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside 5-triphosphatase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphatase activity" EXACT [] synonym: "nucleoside triphosphate hydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "nucleoside-5-triphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] synonym: "unspecific diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.15] xref: EC:3.6.1.15 xref: MetaCyc:NUCLEOSIDE-TRIPHOSPHATASE-RXN xref: reactome:R-HSA-8850846 "NTPDase1 hydrolyzes nucleoside triphosphates" xref: reactome:R-HSA-8851089 "NTPDase2 hydrolyzes nucleoside triphosphates" xref: reactome:R-HSA-8851110 "NTPDase3 hydrolyzes nucleoside triphosphates" xref: reactome:R-HSA-8851234 "NTPDase4 hydrolyzes nucleoside triphosphates" xref: reactome:R-HSA-8851494 "NTPDase7 hydrolyzes nucleoside triphosphates" xref: reactome:R-HSA-8851538 "NTPDase8 hydrolyzes nucleoside triphosphates" xref: RHEA:23680 is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0017112 name: Rab guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rab family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: reactome:R-HSA-5617816 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: reactome:R-HSA-5623521 "RAB3IP stimulates nucleotide exchange on RAB8A" xref: reactome:R-HSA-8875318 "RAB3 GEFs exchange GTP for GDP on RAB3A" xref: reactome:R-HSA-8875320 "RAB5 GEFs exchange GTP for GDP on RAB5" xref: reactome:R-HSA-8876188 "DENND4s exchange GTP for GDP on RAB10" xref: reactome:R-HSA-8876190 "RAB8 GEFs exchange GTP for GDP on RAB8" xref: reactome:R-HSA-8876191 "RAB9 GEFs exchange GTP for GDP on RAB9" xref: reactome:R-HSA-8876193 "RIC1-RGP1 exchanges GTP for GDP on RAB6" xref: reactome:R-HSA-8876454 "DENND3 exchanges GTP for GDP on RAB12" xref: reactome:R-HSA-8876615 "RAB13 GEFs exchange GTP for GDP on RAB13" xref: reactome:R-HSA-8876616 "DENND6A,B exchange GTP for GDP on RAB14" xref: reactome:R-HSA-8876837 "RAB21 GEFs exchange GTP for GDP on RAB21" xref: reactome:R-HSA-8877308 "MADD exchanges GTP for GDP on RAB27" xref: reactome:R-HSA-8877311 "RAB31 GEFs exchange GTP for GDP on RAB31" xref: reactome:R-HSA-8877451 "MON1:CCZ1 exchanges GTP for GDP on RAB7" xref: reactome:R-HSA-8877475 "TRAPPC complexes exchange GTP for GDP on RAB1" xref: reactome:R-HSA-8877612 "DENND1s exchange GTP for GDP on RAB35" xref: reactome:R-HSA-8877760 "HPS1:HPS4 exchange GTP for GDP on RAB32 and RAB38" xref: reactome:R-HSA-8877813 "DENND5A,B exchange GTP for GDP on RAB39" xref: reactome:R-HSA-8877998 "RAB3GAP1:RAB3GAP2 exchanges GTP for GDP on RAB18" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity is_a: GO:0017137 ! Rab GTPase binding [Term] id: GO:0017113 name: dihydropyrimidine dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NADP+ = uracil + NADPH + H+." [EC:1.3.1.2] synonym: "4,5-dihydrothymine: oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "5,6-dihydrouracil:NADP+ 5-oxidoreductase activity" EXACT [EC:1.3.1.2] synonym: "dehydrogenase, dihydrouracil (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.2] synonym: "DHPDH" RELATED [EC:1.3.1.2] synonym: "DHU dehydrogenase activity" EXACT [EC:1.3.1.2] synonym: "dihydropyrimidine dehydrogenase activity" EXACT [] synonym: "dihydrothymine dehydrogenase activity" RELATED [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP)" EXACT [EC:1.3.1.2] synonym: "dihydrouracil dehydrogenase (NADP+) activity" EXACT [EC:1.3.1.2] synonym: "DPD" RELATED [EC:1.3.1.2] synonym: "hydropyrimidine dehydrogenase activity" EXACT [EC:1.3.1.2] xref: EC:1.3.1.2 xref: MetaCyc:1.3.1.2-RXN xref: reactome:R-HSA-73585 "uracil + NADPH + H+ => 5,6-dihydrouracil + NADP+" xref: reactome:R-HSA-73616 "thymine + NADPH + H+ => 5,6-dihydrothymine + NADP+" xref: RHEA:18093 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0017114 name: obsolete wide-spectrum protease inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a protease by a wide-spectrum protease inhibitor. A wide-spectrum protease inhibitor is a protein having a peptide stretch which contains specific cleavage sites for different proteinases enabling inhibition of all four classes of proteinases by formation of a covalent bond between the inhibitor and the protease." [GOC:dph, GOC:tb] comment: This term was made obsolete because it represents a regulator of non-existent molecular function. synonym: "wide-spectrum protease inhibitor activity" EXACT [] synonym: "wide-spectrum proteinase inhibitor" EXACT [] is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0017116 name: single-stranded DNA-dependent ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of single-stranded DNA; drives the unwinding of a DNA helix." [EC:3.6.1.3, GOC:jl] synonym: "ssDNA-dependent ATP-dependent DNA helicase activity" EXACT [GOC:mah] is_a: GO:0004003 ! ATP-dependent DNA helicase activity is_a: GO:0043142 ! single-stranded DNA-dependent ATPase activity [Term] id: GO:0017117 name: single-stranded DNA-dependent ATP-dependent DNA helicase complex namespace: cellular_component def: "A protein complex that possesses single-stranded DNA-dependent DNA helicase activity." [GOC:mah] synonym: "ssDNA-dependent ATP-dependent DNA helicase complex" EXACT [GOC:mah] is_a: GO:0033202 ! DNA helicase complex is_a: GO:1904949 ! ATPase complex [Term] id: GO:0017118 name: lipoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the lipoyl group from lipoyl-AMP to the lysine residue of lipoate-dependent enzyme." [PMID:10103005] is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0017119 name: Golgi transport complex namespace: cellular_component def: "A multisubunit tethering complex of the CATCHR family (complexes associated with tethering containing helical rods) that has a role in tethering vesicles to the Golgi prior to fusion. In yeast, this complex is called the Sec34/35 complex and is composed of eight subunits (Sec34p, Sec35p, Dor1p, Cod1p, Cod2p, Cod3p, Cod4p, and Cod5p). In mammals the subunits are named COG1-8." [GOC:krc, PMID:11980916, PMID:20972446, PMID:9792665] synonym: "COG complex" EXACT [] synonym: "conserved oligomeric Golgi complex" EXACT [] synonym: "Sec34/35 complex" NARROW [] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0099023 ! tethering complex [Term] id: GO:0017120 name: obsolete polyphosphatidylinositol phosphatase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of phosphatidylinositol-3-phosphate, phosphatidylinositol-4-phosphate, and phosphatidylinositol-3,5-bisphosphate, but not PI-4,5-bisphosphate, to phosphatidylinositol; PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization." [PMID:10224048] comment: This term was made obsolete because it represents a gene product. synonym: "polyphosphatidylinositol phosphatase activity" EXACT [] synonym: "polyphosphoinositide phosphatase activity" EXACT [GOC:curators] is_obsolete: true consider: GO:0004438 consider: GO:0034593 consider: GO:0043812 [Term] id: GO:0017121 name: plasma membrane phospholipid scrambling namespace: biological_process def: "The movement of a population of phospholipid molecules from one leaflet of the plasma membrane bilayer to the opposite leaflet, resulting in loss of lipid asymmetry and surface exposure of phosphatidylserine (PS) and phosphatidylethanolamine (PE)." [GOC:cjm, PMID:20043909, PMID:20302864] comment: Note that this term describes the trans-bilayer motion of a population of phospholipid molecules, and should not be confused with 'phospholipid translocation ; GO:0045332'. synonym: "phospholipid scrambling" RELATED [] synonym: "PL scrambling" EXACT [] is_a: GO:0007009 ! plasma membrane organization is_a: GO:0045332 ! phospholipid translocation [Term] id: GO:0017122 name: protein N-acetylglucosaminyltransferase complex namespace: cellular_component def: "A protein complex capable of protein N-acetylglucosaminyltransferase activity, the addition of nucleotide-activated sugars onto the polypeptide according to reaction: UDP-N-acetyl-D-glucosamine + protein = UDP + 4-N-(N-acetyl-D-glucosaminyl)-protein. The complex has different compositions in different species: In mammals it is often a homotrimer, in bacteria a heterotetramer of 2 different subunits." [PMID:15247246] comment: Updated definition as suggested https://github.com/geneontology/go-ontology/issues/16994 synonym: "O-GlcNAc transferase complex" EXACT [GOC:mah] synonym: "UDP-N-acetylglucosamine-peptide N-acetylglucosaminyltransferase" EXACT [GOC:mah] is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0017124 name: SH3 domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins." [GOC:go_curators, Pfam:PF00018] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0017125 name: deoxycytidyl transferase activity namespace: molecular_function alt_id: GO:0019986 def: "Catalysis of the insertion of a dCMP residue opposite a template abasic site in DNA." [PMID:10535901] synonym: "deoxycytidyl transferase activity, template-dependent" NARROW [] xref: reactome:R-HSA-110308 "REV1 inserts dCMP opposite to AP sites in DNA" is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0017126 name: nucleologenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a nucleolus, a small, dense body one or more of which are present in the nucleus of eukaryotic cells." [GOC:jl, ISBN:0198506732] synonym: "nucleolus assembly" NARROW [GOC:mah] synonym: "nucleolus biogenesis" EXACT [] is_a: GO:0007000 ! nucleolus organization is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0017127 name: cholesterol transporter activity namespace: molecular_function def: "Enables the directed movement of cholesterol into, out of or within a cell, or between cells. Cholesterol is the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] xref: reactome:R-HSA-1454928 "ABCG4 may mediate cholesterol efflux" xref: reactome:R-HSA-216723 "4xPALM-C-p-2S-ABCA1 tetramer transports CHOL from transport vesicle membrane to plasma membrane" xref: reactome:R-HSA-265443 "NPC1L1-mediated cholesterol uptake" xref: reactome:R-HSA-265545 "NPC1L1-mediated phytosterol uptake" xref: reactome:R-HSA-266082 "ABCG1-mediated transport of intracellular cholesterol to the cell surface" xref: reactome:R-HSA-8951850 "TSPO:BZRAP1 transports CHOL from outer mitochondrial membrane to inner mitochondrial membrane" is_a: GO:0015248 ! sterol transporter activity [Term] id: GO:0017128 name: phospholipid scramblase activity namespace: molecular_function def: "Catalysis of the movement of phospholipids from one membrane bilayer leaflet to the other, by an ATP-independent mechanism." [GOC:cjm, PMID:20043909, PMID:20302864] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0017129 name: triglyceride binding namespace: molecular_function def: "Interacting selectively and non-covalently with any triester of glycerol." [GOC:jl, ISBN:0198506732] synonym: "triacylglycerol binding" EXACT [GOC:mah] is_a: GO:0008289 ! lipid binding [Term] id: GO:0017130 name: poly(C) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of cytosine residues in an RNA molecule." [GOC:mah] synonym: "poly(C) binding" BROAD [GOC:mah] synonym: "poly(rC) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017131 name: uridine-rich cytoplasmic polyadenylylation element binding namespace: molecular_function def: "Interacting selectively and non-covalently with U-rich sequence in the 3'-end of nuclear-transcribed mRNAs; required for cytoplasmic polyadenylylation." [GOC:krc, PMID:7954828] synonym: "U-rich CPE binding" EXACT [PMID:7954828] synonym: "uridine-rich cytoplasmic polyadenylation element binding" EXACT [] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0017132 name: cAMP-dependent guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase, when activated by cAMP binding." [GOC:mah, PMID:9856955] is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0017133 name: mitochondrial electron transfer flavoprotein complex namespace: cellular_component def: "A protein complex located in the mitochondrion. It contains flavin adenine dinucleotide (FAD) that, together with an acyl-CoA dehydrogenase, forms a system that oxidizes an acyl-CoA molecule and reduces ubiquinone and other acceptors in the mitochondrial electron transport system." [GOC:mtg_sensu, ISBN:0198506732] is_a: GO:0045251 ! electron transfer flavoprotein complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0017134 name: fibroblast growth factor binding namespace: molecular_function alt_id: GO:0048602 alt_id: GO:0048603 alt_id: GO:0048604 alt_id: GO:0048605 alt_id: GO:0048606 alt_id: GO:0048607 def: "Interacting selectively and non-covalently with a fibroblast growth factor." [PMID:9806903] synonym: "FGF 1 binding" NARROW [] synonym: "FGF 2 binding" NARROW [] synonym: "FGF 3 binding" NARROW [] synonym: "FGF 4 binding" NARROW [] synonym: "FGF 5 binding" NARROW [] synonym: "FGF 6 binding" NARROW [] synonym: "FGF binding" EXACT [] synonym: "fibroblast growth factor 1 binding" NARROW [] synonym: "fibroblast growth factor 2 binding" NARROW [] synonym: "fibroblast growth factor 3 binding" NARROW [] synonym: "fibroblast growth factor 4 binding" NARROW [] synonym: "fibroblast growth factor 5 binding" NARROW [] synonym: "fibroblast growth factor 6 binding" NARROW [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0017135 name: obsolete membrane-associated protein with guanylate kinase activity interacting namespace: molecular_function def: "OBSOLETE. The interaction with synapse-associated membrane-associated protein with guanylate kinase activity." [PMID:10207005] comment: This term was made obsolete because it does not represent a molecular function and the term name appears to make no sense. synonym: "membrane-associated protein with guanylate kinase activity interacting" EXACT [] is_obsolete: true consider: GO:0019899 [Term] id: GO:0017136 name: NAD-dependent histone deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from a histone." [EC:3.5.1.17, RHEA:24548] synonym: "SIR2" RELATED [] is_a: GO:0004407 ! histone deacetylase activity is_a: GO:0034979 ! NAD-dependent protein deacetylase activity [Term] id: GO:0017137 name: Rab GTPase binding namespace: molecular_function alt_id: GO:0005084 def: "Interacting selectively and non-covalently with Rab protein, any member of the Rab subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "Rab escort protein activity" NARROW [] synonym: "Rab interactor activity" RELATED [] synonym: "REP" NARROW [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017139 name: obsolete arsenate sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "arsenate sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046685 [Term] id: GO:0017141 name: obsolete antibiotic susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "antibiotic susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046677 [Term] id: GO:0017142 name: obsolete toxin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "toxin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0017143 name: insecticide metabolic process namespace: biological_process alt_id: GO:0017138 def: "The chemical reactions and pathways involving insecticides, chemicals used to kill insects." [GOC:ai] synonym: "insecticide metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009404 ! toxin metabolic process relationship: part_of GO:0017085 ! response to insecticide [Term] id: GO:0017144 name: drug metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a drug, a substance used in the diagnosis, treatment or prevention of a disease; as used here antibiotic substances (see antibiotic metabolism) are considered to be drugs, even if not used in medical or veterinary practice." [GOC:cab2] subset: goslim_chembl subset: goslim_pir synonym: "drug metabolism" EXACT [] xref: Wikipedia:Drug_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0017145 name: stem cell division namespace: biological_process def: "The self-renewing division of a stem cell. A stem cell is an undifferentiated cell, in the embryo or adult, that can undergo unlimited division and give rise to one or several different cell types." [GOC:jid, ISBN:0582227089] synonym: "stem cell renewal" EXACT [] is_a: GO:0051301 ! cell division [Term] id: GO:0017146 name: NMDA selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. NMDA receptors are composed of assemblies of NR1 subunits (Figure 3) and NR2 subunits, which can be one of four separate gene products (NR2A-D). Expression of both subunits are required to form functional channels. The glutamate binding domain is formed at the junction of NR1 and NR2 subunits. NMDA receptors are permeable to calcium ions as well as being permeable to other ions. Thus NMDA receptor activation leads to a calcium influx into the post-synaptic cells, a signal thought to be crucial for the induction of NMDA-receptor dependent LTP and LTD." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] synonym: "N-methyl-D-aspartate selective glutamate receptor complex" EXACT [] synonym: "NMDA-selective glutamate receptor" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034703 ! cation channel complex [Term] id: GO:0017147 name: Wnt-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Wnt-protein, a secreted growth factor involved in signaling." [GOC:jl] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0017148 name: negative regulation of translation namespace: biological_process alt_id: GO:0016478 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA." [GOC:isa_complete] synonym: "down regulation of protein biosynthetic process" EXACT [] synonym: "down-regulation of protein biosynthetic process" EXACT [] synonym: "downregulation of protein biosynthetic process" EXACT [] synonym: "inhibition of protein biosynthetic process" NARROW [] synonym: "negative regulation of protein anabolism" EXACT [] synonym: "negative regulation of protein biosynthesis" EXACT [] synonym: "negative regulation of protein biosynthetic process" EXACT [] synonym: "negative regulation of protein formation" EXACT [] synonym: "negative regulation of protein synthesis" EXACT [] synonym: "protein biosynthesis inhibitor activity" RELATED [] synonym: "protein biosynthetic process inhibitor activity" RELATED [] is_a: GO:0006417 ! regulation of translation is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0032269 ! negative regulation of cellular protein metabolic process is_a: GO:0034249 ! negative regulation of cellular amide metabolic process is_a: GO:2000113 ! negative regulation of cellular macromolecule biosynthetic process relationship: negatively_regulates GO:0006412 ! translation [Term] id: GO:0017149 name: obsolete protein biosynthetic process inhibitor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents involvement in a biological process. synonym: "protein anabolism inhibitor activity" EXACT [] synonym: "protein biosynthetic process inhibitor activity" EXACT [] synonym: "protein formation inhibitor activity" EXACT [] synonym: "protein synthesis inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0017148 [Term] id: GO:0017150 name: tRNA dihydrouridine synthase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA-uracil + acceptor = tRNA-dihydrouridine + reduced acceptor." [PMID:11983710] xref: MetaCyc:RXN0-1281 xref: reactome:R-HSA-6782296 "DUS2:EPRS reduces uridine to dihydrouridine in tRNAs" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0017151 name: DEAD/H-box RNA helicase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme DEAD/H-box RNA helicase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0017153 name: sodium:dicarboxylate symporter activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dicarboxylate(out) + Na+(out) = dicarboxylate(in) + Na+(in)." [GOC:ai] synonym: "sodium:dicarboxylate cotransporter activity" BROAD [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity is_a: GO:0005343 ! organic acid:sodium symporter activity [Term] id: GO:0017154 name: semaphorin receptor activity namespace: molecular_function def: "Combining with a semaphorin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:mah, GOC:signaling, PMID:15239958] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0017155 name: obsolete sodium:hydrogen antiporter regulator activity namespace: molecular_function alt_id: GO:0030040 def: "OBSOLETE." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because it represents a biological process. synonym: "sodium:hydrogen antiporter regulator activity" EXACT [] synonym: "sodium:proton antiporter regulator" EXACT [] is_obsolete: true [Term] id: GO:0017156 name: calcium ion regulated exocytosis namespace: biological_process def: "The release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell, induced by a rise in cytosolic calcium-ion levels." [GOC:go_curators] comment: Note that the calcium regulated exocytosis pathway can be leaky: some level of exocytosis via this pathway occurs spontaneously. This phenomenon underlies spontaneous neurotransmitter release from presynapses. This phenomenon is distinct from the unregulated, calcium independent exocytosis pathway. synonym: "calcium ion-dependent exocytosis" EXACT [] is_a: GO:0045055 ! regulated exocytosis [Term] id: GO:0017157 name: regulation of exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocytosis." [GOC:go_curators] is_a: GO:0060627 ! regulation of vesicle-mediated transport is_a: GO:1903530 ! regulation of secretion by cell relationship: regulates GO:0006887 ! exocytosis [Term] id: GO:0017158 name: regulation of calcium ion-dependent exocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of calcium ion-dependent exocytosis." [GOC:go_curators] is_a: GO:1903305 ! regulation of regulated secretory pathway relationship: regulates GO:0017156 ! calcium ion regulated exocytosis [Term] id: GO:0017159 name: pantetheine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantetheine + H(2)O = (R)-pantothenate + cysteamine." [EC:3.5.1.92, RHEA:13445] synonym: "(R)-pantetheine amidohydrolase activity" EXACT [EC:3.5.1.92] synonym: "pantetheinase activity" EXACT [EC:3.5.1.92] synonym: "vanin" RELATED [EC:3.5.1.92] synonym: "vanin-1" RELATED [EC:3.5.1.92] xref: EC:3.5.1.92 xref: KEGG:R02973 xref: MetaCyc:3.5.1.92-RXN xref: reactome:R-HSA-8938300 "Vanin hydrolyses pantetheine to PanK, 2AET" xref: RHEA:13445 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0017160 name: Ral GTPase binding namespace: molecular_function alt_id: GO:0034989 def: "Interacting selectively and non-covalently with Ral protein, any member of the Ral subfamily of the Ras superfamily of monomeric GTPases." [GOC:mah] synonym: "GTP-Ral binding" NARROW [] synonym: "Ral interactor activity" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0017161 name: inositol-1,3,4-trisphosphate 4-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-myo-inositol 1,3,4-trisphosphate + H2O = myo-inositol 1,3-bisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: reactome:R-HSA-1855180 "I(1,3,4)P3 is dephosphorylated to I(1,3)P2 by INPP4A/B in the cytosol" is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0017162 name: aryl hydrocarbon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an aryl hydrocarbon receptor." [GOC:ai] is_a: GO:0005102 ! signaling receptor binding is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0017163 name: obsolete basal transcription repressor activity namespace: molecular_function def: "OBSOLETE. Any transcription regulator activity that prevents or downregulates basal transcription. Basal transcription results from transcription that is controlled by the minimal complement of proteins necessary to reconstitute transcription from a minimal promoter." [GOC:dph, GOC:tb, http://tfib.med.harvard.edu/transcription/basaltx.html] comment: This term was obsoleted because "general/nonspecific/basal" transcription vs "specific" transcription were determined not to be separable, distinct process. Thus, terms trying to distinguish "general/nonspecific/basal" transcription from "specific" transcription were removed from both the Molecular Function and the Biological Process ontologies. In addition, this Molecular Function term was defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of your repressor is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "basal transcription repressor activity" EXACT [] is_obsolete: true consider: GO:0001141 consider: GO:0001227 consider: GO:0045892 [Term] id: GO:0017164 name: obsolete nicotinic acetylcholine receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "nicotinic acetylcholine receptor-associated protein activity" EXACT [] is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0017165 name: obsolete dipeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides Asp-Xaa; does not act on peptides with N-terminal Glu, Asn or Gln, nor does it cleave isoaspartyl peptides." [EC:3.4.13.21] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-aspartyl dipeptidase activity" EXACT [] synonym: "aspartyl dipeptidase activity" EXACT [EC:3.4.13.21] synonym: "dipeptidase E activity" EXACT [] synonym: "PepE gene product (Salmonella typhimurium) activity" NARROW [EC:3.4.13.21] synonym: "peptidase E activity" BROAD [EC:3.4.13.21] xref: EC:3.4.13.21 xref: MetaCyc:3.4.13.21-RXN is_obsolete: true replaced_by: GO:0016805 [Term] id: GO:0017166 name: vinculin binding namespace: molecular_function def: "Interacting selectively and non-covalently with vinculin, a protein found in muscle, fibroblasts, and epithelial cells that binds actin and appears to mediate attachment of actin filaments to integral proteins of the plasma membrane." [ISBN:0721662544] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0017168 name: 5-oxoprolinase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxo-L-proline + ATP + 2 H(2)O = L-glutamate + ADP + 2 H(+) + phosphate." [EC:3.5.2.9, RHEA:10348] synonym: "5-OPase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-prolinase activity" EXACT [EC:3.5.2.9] synonym: "5-oxo-L-proline amidohydrolase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "5-oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "L-pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "oxoprolinase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolysing)" EXACT [EC:3.5.2.9] synonym: "pyroglutamase (ATP-hydrolyzing) activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamate hydrolase activity" EXACT [EC:3.5.2.9] synonym: "pyroglutamic hydrolase activity" EXACT [EC:3.5.2.9] xref: EC:3.5.2.9 xref: KEGG:R00251 xref: MetaCyc:5-OXOPROLINASE-ATP-HYDROLYSING-RXN xref: reactome:R-HSA-1247935 "OPLAH hydrolyses OPRO to L-Glu" xref: RHEA:10348 xref: Wikipedia:5-oxoprolinase_(ATP-hydrolysing) is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0017169 name: CDP-alcohol phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP + alcohol = CMP + phosphatidyl alcohol." [GOC:ai] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0017170 name: obsolete KU70 binding namespace: molecular_function def: "OBSOLETE. Interacting selectively and non-covalently with Ku70, a protein involved in non-homologous DNA end joining." [GOC:mah, PMID:14739985] comment: This term was made obsolete because it represents binding to an individual protein. synonym: "KU70 binding" EXACT [] is_obsolete: true [Term] id: GO:0017171 name: serine hydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [Wikipedia:Serine_hydrolase] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0017172 name: cysteine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + O(2) = 3-sulfino-L-alanine + H(+)." [EC:1.13.11.20, RHEA:20441] xref: EC:1.13.11.20 xref: KEGG:R00893 xref: MetaCyc:CYSTEINE-DIOXYGENASE-RXN xref: reactome:R-HSA-1614645 "CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine" xref: RHEA:20441 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0017174 name: glycine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glycine = S-adenosyl-L-homocysteine + sarcosine." [EC:2.1.1.20] synonym: "glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "GNMT" RELATED [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine methyltransferase activity" EXACT [EC:2.1.1.20] synonym: "S-adenosyl-L-methionine:glycine N-methyltransferase activity" EXACT [EC:2.1.1.20] xref: EC:2.1.1.156 xref: EC:2.1.1.162 xref: EC:2.1.1.20 xref: KEGG:R00367 xref: MetaCyc:2.1.1.162-RXN xref: MetaCyc:GLYCINE-N-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-6798317 "GNMT tetramer transfers methyl group from AdoMet to Gly to form AdoHyc and SARC" xref: RHEA:19937 is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0017175 name: obsolete IMP-GMP specific 5'-nucleotidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the conversion of 5'-ribonucleotides to ribonucleosides and phosphate, with specificity for IMP or GMP 5'-ribonucleotides and H2O as a nucleophile." [EC:3.1.3.5, GOC:krc] comment: This term was made obsolete because it represents a gene product with two different activities. synonym: "IMP-GMP specific 5'-nucleotidase activity" EXACT [] is_obsolete: true consider: GO:0050484 [Term] id: GO:0017176 name: phosphatidylinositol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + phosphatidylinositol = UDP + N-acetyl-D-glucosaminylphosphatidylinositol." [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:1-phosphatidyl-1D-myo-inositol 6-(N-acetyl-alpha-D-glucosaminyl)transferase activity" EXACT [EC:2.4.1.198] synonym: "UDP-N-acetyl-D-glucosamine:phosphatidylinositol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha-1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] synonym: "uridine diphosphoacetylglucosamine alpha1,6-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.198] xref: EC:2.4.1.198 xref: MetaCyc:2.4.1.198-RXN xref: RHEA:14789 is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0017177 name: glucosidase II complex namespace: cellular_component def: "A heterodimeric complex that catalyzes the trimming of glucose residues from N-linked core glycans on newly synthesized glycoproteins." [PMID:10464333, PMID:8910335] comment: Note that alpha-glucosidase I functions as a monomer, and therefore does not have a corresponding cellular component term. synonym: "alpha-glucosidase II complex" RELATED [GOC:19605557, GOC:vw] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0017178 name: diphthine-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphthine + NH(4)(+) = ADP + diphthamide + H(+) + phosphate." [EC:6.3.1.14, RHEA:19753] synonym: "diphthamide synthase activity" EXACT [EC:6.3.1.14] synonym: "diphthamide synthetase activity" EXACT [EC:6.3.1.14] synonym: "diphthine:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.14] xref: EC:6.3.1.14 xref: KEGG:R03613 xref: MetaCyc:DIPHTINE--AMMONIA-LIGASE-RXN xref: reactome:R-HSA-5358475 "DPH6 ligates ammonium to diphthine-EEF2" xref: RHEA:19753 is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0017179 name: peptidyl-diphthine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthine metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017180 name: peptidyl-diphthine biosynthetic process from peptidyl-histidine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-diphthine from other compounds, including peptidyl-histidine." [GOC:go_curators] synonym: "peptidyl-diphthine anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthine synthesis from peptidyl-histidine" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0017181 name: peptidyl-diphthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthine, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthine breakdown" EXACT [] synonym: "peptidyl-diphthine catabolism" EXACT [] synonym: "peptidyl-diphthine degradation" EXACT [] is_a: GO:0017179 ! peptidyl-diphthine metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017182 name: peptidyl-diphthamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthamide metabolism" EXACT [] is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0017183 name: peptidyl-diphthamide biosynthetic process from peptidyl-histidine namespace: biological_process def: "The modification of peptidyl-histidine to 2'-(3-carboxamido-3-(trimethylammonio)propyl)-L-histidine, known as diphthamide, found in translation elongation factor EF-2. The process occurs in eukaryotes and archaea but not eubacteria." [GOC:pde, PMID:20559380, RESID:AA0040] synonym: "peptidyl-diphthamide anabolism from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide formation from peptidyl-histidine" EXACT [] synonym: "peptidyl-diphthamide synthesis from peptidyl-histidine" EXACT [] xref: RESID:AA0040 is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:1900247 ! regulation of cytoplasmic translational elongation [Term] id: GO:0017184 name: peptidyl-diphthamide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptidyl-diphthamide, a modified histidine residue." [GOC:go_curators] synonym: "peptidyl-diphthamide breakdown" EXACT [] synonym: "peptidyl-diphthamide catabolism" EXACT [] synonym: "peptidyl-diphthamide degradation" EXACT [] is_a: GO:0017182 ! peptidyl-diphthamide metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0017185 name: peptidyl-lysine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-lysine to form peptidyl-hydroxylysine." [GOC:ai] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0017186 name: peptidyl-pyroglutamic acid biosynthetic process, using glutaminyl-peptide cyclotransferase namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-pyroglutamic acid, catalyzed by glutaminyl-peptide cyclotransferase." [RESID:AA0031] comment: See also the molecular function term 'glutaminyl-peptide cyclotransferase activity ; GO:0016603'. synonym: "2-pyrrolidone-5-carboxylic acid biosynthesis" EXACT [] synonym: "2-pyrrolidone-5-carboxylic acid biosynthetic process" EXACT [] synonym: "peptidyl-pyroglutamic acid anabolism, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid formation, using glutaminyl-peptide cyclotransferase" EXACT [] synonym: "peptidyl-pyroglutamic acid synthesis, using glutaminyl-peptide cyclotransferase" EXACT [] xref: RESID:AA0031 is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017187 name: peptidyl-glutamic acid carboxylation namespace: biological_process def: "The gamma-carboxylation of peptidyl-glutamic acid; catalyzed by the vitamin K dependent gamma-glutamyl carboxylase." [RESID:AA0032] comment: See also the molecular function term 'gamma-glutamyl carboxylase activity ; GO:0008488'. xref: RESID:AA0032 is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0017188 name: aspartate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + acetyl-CoA = N-acetyl-L-aspartate + CoA + H(+)." [EC:2.3.1.17, RHEA:14165] synonym: "acetyl-CoA:L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "aspartate acetyltransferase activity" EXACT [EC:2.3.1.17] synonym: "L-aspartate N-acetyltransferase activity" EXACT [EC:2.3.1.17] xref: EC:2.3.1.17 xref: KEGG:R00487 xref: MetaCyc:ASPARTATE-N-ACETYLTRANSFERASE-RXN xref: reactome:R-HSA-8954468 "NAT8L transfers acetyl group from Ac-CoA to L-Asp, forming NAA" xref: RHEA:14165 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0017189 name: N-terminal peptidyl-alanine acetylation namespace: biological_process def: "The acetylation of the N-terminal alanine of proteins; catalyzed by peptide alpha-N-acetyltransferase or other enzymes of this class, such as ribosomal-protein-alanine N-acetyltransferase." [RESID:AA0041] comment: See also the molecular function terms 'peptide alpha-N-acetyltransferase activity ; GO:0004596' and 'ribosomal-protein-alanine N-acetyltransferase activity ; GO:0008999'. xref: RESID:AA0041 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0017190 name: N-terminal peptidyl-aspartic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal aspartic acid of proteins; catalyzed by aspartate N-acetyltransferase." [RESID:AA0042] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. xref: RESID:AA0042 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0017192 name: N-terminal peptidyl-glutamine acetylation namespace: biological_process def: "The acetylation of a glutamine residue in protein to form the N5-methyl-L-glutamine derivative. The occurrence of this modification has not been confirmed. Its annotation in sequence databases is either due to the misidentification of 2-pyrrolidone-5-carboxylic acid, or to inappropriate homolog comparisons when proteolytic modification is more probable." [RESID:AA0045] xref: RESID:AA0045 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0017193 name: N-terminal peptidyl-glycine acetylation namespace: biological_process def: "The acetylation of the N-terminal glycine of proteins to form the derivative N-acetylglycine." [RESID:AA0046] xref: RESID:AA0046 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0017194 name: N-terminal peptidyl-isoleucine acetylation namespace: biological_process def: "The acetylation of the N-terminal isoleucine of proteins to form the derivative N-acetyl-L-isoleucine. The occurrence of this modification has not been confirmed." [RESID:AA0047] xref: RESID:AA0047 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0017195 name: N-terminal peptidyl-lysine N2-acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins to form the derivative N2-acetyl-L-lysine. The occurrence of this modification has not been confirmed." [RESID:AA0048] xref: RESID:AA0048 is_a: GO:0018076 ! N-terminal peptidyl-lysine acetylation [Term] id: GO:0017196 name: N-terminal peptidyl-methionine acetylation namespace: biological_process def: "The acetylation of the N-terminal methionine of proteins to form the derivative N-acetyl-L-methionine." [RESID:AA0049] xref: RESID:AA0049 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0017197 name: N-terminal peptidyl-proline acetylation namespace: biological_process def: "The acetylation of the N-terminal proline of proteins to form the derivative N-acetyl-L-proline." [RESID:AA0050] xref: RESID:AA0050 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0017198 name: N-terminal peptidyl-serine acetylation namespace: biological_process def: "The acetylation of the N-terminal serine of proteins to form the derivative N-acetyl-L-serine." [RESID:AA0051] xref: RESID:AA0051 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0017199 name: N-terminal peptidyl-threonine acetylation namespace: biological_process def: "The acetylation of the N-terminal threonine of proteins to form the derivative N-acetyl-L-threonine; catalyzed by peptide alpha-N-acetyltransferase." [RESID:AA0052] comment: See also the molecular function term 'peptide alpha-N-acetyltransferase activity ; GO:0004596'. xref: RESID:AA0052 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018000 name: N-terminal peptidyl-tyrosine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-tyrosine." [RESID:AA0053] xref: RESID:AA0053 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018001 name: N-terminal peptidyl-valine acetylation namespace: biological_process def: "The acetylation of the N-terminal tyrosine of proteins to form the derivative N-acetyl-L-valine." [RESID:AA0054] xref: RESID:AA0054 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018002 name: N-terminal peptidyl-glutamic acid acetylation namespace: biological_process def: "The acetylation of the N-terminal glutamic acid of proteins to form the derivate acetyl-glutamic acid." [RESID:AA0044] comment: See also the molecular function term 'aspartate N-acetyltransferase activity ; GO:0017188'. xref: RESID:AA0044 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018003 name: peptidyl-lysine N6-acetylation namespace: biological_process def: "The acetylation of the peptidyl-lysine of proteins to form the derivative peptidyl-N6-acetyl-L-lysine." [RESID:AA0055] comment: See also the molecular function term 'tubulin N-acetyltransferase activity ; GO:0019799'. xref: RESID:AA0055 is_a: GO:0018393 ! internal peptidyl-lysine acetylation [Term] id: GO:0018004 name: N-terminal protein formylation namespace: biological_process def: "The formylation of the N-terminal amino acid of proteins." [GOC:ai] is_a: GO:0018256 ! protein formylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018005 name: N-terminal peptidyl-glycine N-formylation namespace: biological_process def: "The formylation of the N-terminal glycine of proteins to form the derivative N-formylglycine." [RESID:AA0057] xref: RESID:AA0057 is_a: GO:0018004 ! N-terminal protein formylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018006 name: N-terminal protein amino acid glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal amino acid of proteins." [GOC:ai] is_a: GO:0018321 ! protein glucuronylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018007 name: N-terminal peptidyl-glycine N-glucuronylation namespace: biological_process def: "The glucuronylation of the N-terminal glycine of proteins to form the derivative D-glucuronyl-N-glycine." [RESID:AA0058] xref: RESID:AA0058 is_a: GO:0018006 ! N-terminal protein amino acid glucuronylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018008 name: N-terminal peptidyl-glycine N-myristoylation namespace: biological_process def: "The myristoylation of the N-terminal glycine of proteins to form the derivative N-myristoyl-glycine." [RESID:AA0059] synonym: "N-terminal peptidyl-glycine N-myristylation" EXACT [] xref: RESID:AA0059 is_a: GO:0006499 ! N-terminal protein myristoylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018009 name: N-terminal peptidyl-L-cysteine N-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a nitrogen (N) atom in an N-terminal cysteine residue to form N-palmitoyl-L-cysteine." [RESID:AA0060] xref: RESID:AA0060 is_a: GO:0006500 ! N-terminal protein palmitoylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018010 name: glycoprotein N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + glycoprotein = CoA + N-palmitoylglycoprotein." [EC:2.3.1.96] synonym: "mucus glycoprotein fatty acyltransferase" NARROW [EC:2.3.1.96] synonym: "palmitoyl-CoA:glycoprotein N-palmitoyltransferase activity" EXACT [EC:2.3.1.96] xref: EC:2.3.1.96 xref: MetaCyc:GLYCOPROTEIN-N-PALMITOYLTRANSFERASE-RXN is_a: GO:0019105 ! N-palmitoyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0018011 name: N-terminal peptidyl-alanine methylation namespace: biological_process def: "The methylation of the N-terminal alanine of proteins." [RESID:AA0061, RESID:AA0062] xref: RESID:AA0061 xref: RESID:AA0062 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018012 name: N-terminal peptidyl-alanine trimethylation namespace: biological_process def: "The trimethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N,N,N-trimethyl-L-alanine." [RESID:AA0062] xref: RESID:AA0062 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0018013 name: N-terminal peptidyl-glycine methylation namespace: biological_process def: "The methylation of the N-terminal glycine of proteins to form the derivative N-methylglycine." [RESID:AA0063] xref: RESID:AA0063 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018014 name: N-terminal peptidyl-methionine methylation namespace: biological_process def: "The methylation of the N-terminal methionine of proteins to form the derivative N-methyl-L-methionine." [RESID:AA0064] xref: RESID:AA0064 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018015 name: N-terminal peptidyl-phenylalanine methylation namespace: biological_process def: "The methylation of the N-terminal phenylalanine of proteins to form the derivative N-methyl-L-phenylalanine." [RESID:AA0065] xref: RESID:AA0065 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018016 name: N-terminal peptidyl-proline dimethylation namespace: biological_process def: "The methylation of the N-terminal proline of proteins to form the derivative N,N-dimethyl-L-proline." [RESID:AA0066] xref: RESID:AA0066 is_a: GO:0035568 ! N-terminal peptidyl-proline methylation [Term] id: GO:0018019 name: N-terminal peptidyl-glutamine methylation namespace: biological_process def: "The methylation of a glutamine residue in proteins to form the peptidyl-N5-methyl-L-glutamine derivative." [RESID:AA0071] xref: RESID:AA0071 is_a: GO:0006480 ! N-terminal protein amino acid methylation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018020 name: peptidyl-glutamic acid methylation namespace: biological_process def: "The addition of a methyl group to a glutamic acid residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation [Term] id: GO:0018021 name: peptidyl-histidine methylation namespace: biological_process def: "The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine) or peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine)." [RESID:AA0073, RESID:AA0317] xref: RESID:AA0073 xref: RESID:AA0317 is_a: GO:0006479 ! protein methylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018022 name: peptidyl-lysine methylation namespace: biological_process def: "The methylation of peptidyl-lysine to form either the mono-, di- or trimethylated derivative." [GOC:ai] is_a: GO:0006479 ! protein methylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018023 name: peptidyl-lysine trimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6,N6-trimethyl-L-lysine." [RESID:AA0074] xref: RESID:AA0074 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018024 name: histone-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone L-lysine = S-adenosyl-L-homocysteine + histone N6-methyl-L-lysine. The methylation of peptidyl-lysine in histones forms N6-methyl-L-lysine, N6,N6-dimethyl-L-lysine and N6,N6,N6-trimethyl-L-lysine derivatives." [EC:2.1.1.43, RESID:AA0074, RESID:AA0075, RESID:AA0076] synonym: "histone H1-specific S-adenosylmethionine:protein-lysine N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "histone-lysine N-methylase activity" EXACT [GOC:mah] synonym: "protein (lysine) methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "protein methylase 3 activity" NARROW [EC:2.1.1.43] synonym: "protein methylase III activity" NARROW [EC:2.1.1.43] synonym: "protein methyltransferase II activity" NARROW [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.43] synonym: "S-adenosyl-L-methionine:histone-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.43] xref: EC:2.1.1.43 xref: MetaCyc:HISTONE-LYSINE-N-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-3788745 "EHMT1:EHMT2 methylates IL8 promoter" xref: reactome:R-HSA-3788748 "EHMT1:EHMT2 methylates IL6 promoter" xref: reactome:R-HSA-4827382 "SUV39H1 (KMT1A), SUV39H2 (KTM1B), SETDB1 (KMT1E), SETDB2 (KMT1F) methylate dimethyl-lysine-10 of histone H3 (H3K9)" xref: reactome:R-HSA-4827383 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C) methylate lysine-37 of histone H3 (H3K36)" xref: reactome:R-HSA-5159245 "SETD3, SETD7 (KMT7), WHSC1L1 (KMT3F), Core MLL complex methylate lysine-5 of histone H3 (H3K4)" xref: reactome:R-HSA-5244692 "Core MLL complex, SMYD3, PRDM9 methylate dimethyl-lysine-5 of histone H3 (H3K4)" xref: reactome:R-HSA-5423038 "SETD8 (KMT5A) methylates lysine-21 of histone H4 (H4K20)" xref: reactome:R-HSA-5634729 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates methyl-lysine-10 of histone H3 (H3K9)" xref: reactome:R-HSA-5634750 "EHMT1:EHMT2 (KMT1D:KMT1C) methylates lysine-10 of histone H3 (H3K9)" xref: reactome:R-HSA-5634802 "MECOM (KMT8E), PRDM16 (KMT8F) methylate lysine-10 of replicative histone H3 (H3K9)" xref: reactome:R-HSA-5637686 "WHSC1L1 (KMT3F), Core MLL complex, SMYD3 (KMT3E) methylate methyl-lysine-5 of histone H3 (H3K4)" xref: reactome:R-HSA-5638141 "SETD2 (KMT3A) methylates dimethyl-lysine-37 of histone H3 (H3K36)" xref: reactome:R-HSA-5638157 "WHSC1 (KMT3G), NSD1 (KMT3B), SMYD2 (KMT3C), ASH1L methylate methyl-lysine-37 of histone H3 (H3K36)" xref: reactome:R-HSA-5638332 "PRC2 (EZH2) Core:AEBP2 methylates lysine-28 of histone H3 (H3K27)" xref: reactome:R-HSA-5638333 "WHSC1 (KMT3G) methylates lysine-28 of histone H3 (H3K27)" xref: reactome:R-HSA-5649764 "DOT1L (KMT4) methylates methyl-lysine-80 of histone H3 (H3K79)" xref: reactome:R-HSA-5649799 "DOT1L (KMT4) methylates dimethyl-lysine-80 of histone H3 (H3K79)" xref: reactome:R-HSA-5649800 "WHSC1L1 (KMT3F) methylates methyl-lysine-28 of histone H3 (H3K27)" xref: reactome:R-HSA-5649801 "DOT1L (KMT4) methylates lysine-80 of histone H3 (H3K79)" xref: reactome:R-HSA-5649802 "WHSC1L1 (KMT3F) methylates dimethyl-lysine-28 of histone H3 (H3K27)" xref: reactome:R-HSA-5651654 "SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)" xref: reactome:R-HSA-5651657 "SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)" xref: RESID:AA0074 xref: RESID:AA0075 xref: RESID:AA0076 is_a: GO:0016279 ! protein-lysine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity [Term] id: GO:0018025 name: calmodulin-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + calmodulin L-lysine = S-adenosyl-L-homocysteine + calmodulin N6-methyl-L-lysine." [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosyl-L-methionine:calmodulin-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.60] synonym: "S-adenosylmethionine:calmodulin (lysine) N-methyltransferase activity" EXACT [EC:2.1.1.60] xref: EC:2.1.1.60 xref: MetaCyc:2.1.1.60-RXN xref: reactome:R-HSA-6786205 "KAMKMT transfers 3xCH3 groups from 3xAdoMet to CALM1" is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0018026 name: peptidyl-lysine monomethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6-methyl-L-lysine." [RESID:AA0076] xref: RESID:AA0076 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018027 name: peptidyl-lysine dimethylation namespace: biological_process def: "The methylation of peptidyl-lysine to form peptidyl-N6,N6-dimethyl-L-lysine." [RESID:AA0075] xref: RESID:AA0075 is_a: GO:0018022 ! peptidyl-lysine methylation [Term] id: GO:0018028 name: peptidyl-lysine myristoylation namespace: biological_process def: "The myristoylation of peptidyl-lysine to form peptidyl-N6-myristoyl-L-lysine." [RESID:AA0078] synonym: "peptidyl-lysine myristylation" EXACT [] xref: RESID:AA0078 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0018029 name: peptidyl-lysine palmitoylation namespace: biological_process def: "The palmitoylation of peptidyl-lysine to form peptidyl-N6-palmitoyl-L-lysine." [RESID:AA0077] xref: RESID:AA0077 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018030 name: peptidyl-lysine N6-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0018031 name: peptidyl-lysine N6-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to the N6 nitrogen atom on a lysine residue of a peptide or protein molecule." [GOC:mah] xref: EC:2.3.1 is_a: GO:0019105 ! N-palmitoyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0018032 name: protein amidation namespace: biological_process def: "Addition of an amide group from a glycine to a protein amino acid." [UniProtKB-KW:KW-0027] synonym: "protein amino acid amidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018033 name: protein C-terminal amidation namespace: biological_process def: "The formation of a C-terminal amide by hydrolysis and oxidation of an interior peptide in a secreted protein." [GOC:ai] is_a: GO:0018032 ! protein amidation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018034 name: C-terminal peptidyl-alanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-alanine amide by hydrolysis and oxidation of an interior Ala-Gly peptide in a secreted protein." [RESID:AA0081] xref: RESID:AA0081 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018035 name: C-terminal peptidyl-arginine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-arginine amide by hydrolysis and oxidation of an interior Arg-Gly peptide in a secreted protein." [RESID:AA0082] xref: RESID:AA0082 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018036 name: C-terminal peptidyl-asparagine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-asparagine amide by hydrolysis and oxidation of an interior Asn-Gly peptide in a secreted protein." [RESID:AA0083] xref: RESID:AA0083 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018037 name: C-terminal peptidyl-aspartic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-aspartic acid 1-amide by hydrolysis and oxidation of an interior Asp-Gly peptide in a secreted protein." [RESID:AA0084] xref: RESID:AA0084 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018038 name: C-terminal peptidyl-cysteine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-cysteine amide by hydrolysis and oxidation of an interior Cys-Gly peptide in a secreted protein." [RESID:AA0085] xref: RESID:AA0085 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018039 name: C-terminal peptidyl-glutamine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamine amide by hydrolysis and oxidation of an interior Gln-Gly peptide in a secreted protein." [RESID:AA0086] xref: RESID:AA0086 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018040 name: C-terminal peptidyl-glutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glutamic acid amide by hydrolysis and oxidation of an interior Glu-Gly peptide in a secreted protein." [RESID:AA0087] xref: RESID:AA0087 is_a: GO:0018033 ! protein C-terminal amidation [Term] id: GO:0018041 name: C-terminal peptidyl-glycine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-glycine acid amide by hydrolysis and oxidation of an interior Gly-Gly peptide in a secreted protein." [RESID:AA0088] xref: RESID:AA0088 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018042 name: C-terminal peptidyl-histidine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-histidine amide by hydrolysis and oxidation of an interior His-Gly peptide in a secreted protein." [RESID:AA0089] xref: RESID:AA0089 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018043 name: C-terminal peptidyl-isoleucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-isoleucine amide by hydrolysis and oxidation of an interior Ile-Gly peptide in a secreted protein." [RESID:AA0090] xref: RESID:AA0090 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018203 ! peptidyl-isoleucine modification [Term] id: GO:0018044 name: C-terminal peptidyl-leucine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-leucine amide by hydrolysis and oxidation of an interior Leu-Gly peptide in a secreted protein." [RESID:AA0091] xref: RESID:AA0091 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018204 ! peptidyl-leucine modification [Term] id: GO:0018045 name: C-terminal peptidyl-lysine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-lysine amide by hydrolysis and oxidation of an interior Lys-Gly peptide in a secreted protein." [RESID:AA0092] xref: RESID:AA0092 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018046 name: C-terminal peptidyl-methionine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-methionine amide by hydrolysis and oxidation of an interior Met-Gly peptide in a secreted protein." [RESID:AA0093] xref: RESID:AA0093 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018047 name: C-terminal peptidyl-phenylalanine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-phenylalanine amide by hydrolysis and oxidation of an interior Phe-Gly peptide in a secreted protein." [RESID:AA0094] xref: RESID:AA0094 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018048 name: C-terminal peptidyl-proline amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-proline amide by hydrolysis and oxidation of an interior Pro-Gly peptide in a secreted protein." [RESID:AA0095] xref: RESID:AA0095 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018049 name: C-terminal peptidyl-serine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-serine amide by hydrolysis and oxidation of an interior Ser-Gly peptide in a secreted protein." [RESID:AA0096] xref: RESID:AA0096 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018050 name: C-terminal peptidyl-threonine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-threonine amide by hydrolysis and oxidation of an interior Thr-Gly peptide in a secreted protein." [RESID:AA0097] xref: RESID:AA0097 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018051 name: C-terminal peptidyl-tryptophan amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tryptophan amide by hydrolysis and oxidation of an interior Trp-Gly peptide in a secreted protein." [RESID:AA0098] xref: RESID:AA0098 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018052 name: C-terminal peptidyl-tyrosine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-tyrosine amide by hydrolysis and oxidation of an interior Tyr-Gly peptide in a secreted protein." [RESID:AA0099] xref: RESID:AA0099 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018053 name: C-terminal peptidyl-valine amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-valine amide by hydrolysis and oxidation of an interior Val-Gly peptide in a secreted protein." [RESID:AA0100] xref: RESID:AA0100 is_a: GO:0018033 ! protein C-terminal amidation is_a: GO:0018213 ! peptidyl-valine modification [Term] id: GO:0018054 name: peptidyl-lysine biotinylation namespace: biological_process def: "The covalent modification of peptidyl-lysine by biotin to form peptidyl-N6-biotinyl-L-lysine." [RESID:AA0117] xref: RESID:AA0117 is_a: GO:0009305 ! protein biotinylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018057 name: peptidyl-lysine oxidation namespace: biological_process def: "The oxidation of the terminal amino-methylene groups of peptidyl-L-lysine or peptidyl-5-hydroxy-L-lysine to aldehyde groups to form allysine or hydroxyallysine residues, respectively; these are intermediates in the formation of covalent cross-links between adjacent polypeptide chains in proteins such as collagens." [ISBN:0198547684, RESID:AA0121] xref: RESID:AA0121 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018058 name: N-terminal protein amino acid deamination, from amino carbon namespace: biological_process def: "The oxidative deamination of the alpha carbon of an encoded N-terminal amino acid, to form pyruvic acid retaining an amide bond between its 1-carboxyl group and the adjacent residue. The pyruvate 2-oxo group may become an enzyme active site, or it may be reduced to an alcohol." [RESID:AA0127, RESID:AA0128, RESID:AA0129] xref: RESID:AA0127 xref: RESID:AA0128 xref: RESID:AA0129 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018277 ! protein deamination is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0018059 name: N-terminal peptidyl-serine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-serine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018060 name: N-terminal peptidyl-cysteine deamination namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018061 name: peptidyl-L-3-phenyllactic acid biosynthetic process from peptidyl-phenylalanine namespace: biological_process def: "The modification of a N-terminal peptidyl-phenylalanine residue by either oxidative deamination or by transamination and subsequent reduction to form peptidyl-L-3-phenyllactic acid." [RESID:AA0128] synonym: "peptidyl-L-3-phenyllactic acid anabolism from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid formation from peptidyl-phenylalanine" EXACT [] synonym: "peptidyl-L-3-phenyllactic acid synthesis from peptidyl-phenylalanine" EXACT [] xref: RESID:AA0128 is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018062 name: peptidyl-tryptophan succinylation namespace: biological_process def: "The modification of an N-terminal peptidyl-tryptophan residue to form peptidyl-N2-succinyl-L-tryptophan." [RESID:AA0130] xref: RESID:AA0130 is_a: GO:0018211 ! peptidyl-tryptophan modification is_a: GO:0018335 ! protein succinylation is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018063 name: cytochrome c-heme linkage namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme." [RESID:AA0134, RESID:AA0135] synonym: "cytochrome c-haem linkage" EXACT [] xref: RESID:AA0134 xref: RESID:AA0135 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018064 name: protein-histidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-histidine = S-adenosyl-L-homocysteine + protein N-methyl-L-histidine." [EC:2.1.1.85] synonym: "actin-specific histidine methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "peptidyl-histidine N-methyltransferase activity" EXACT [] synonym: "protein (histidine) methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "protein methylase IV activity" NARROW [EC:2.1.1.85] synonym: "S-adenosyl methionine:protein-histidine N-methyltransferase activity" EXACT [EC:2.1.1.85] synonym: "S-adenosyl-L-methionine:protein-L-histidine N-tele-methyltransferase activity" EXACT [EC:2.1.1.85] xref: EC:2.1.1.85 xref: MetaCyc:2.1.1.85-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018065 name: protein-cofactor linkage namespace: biological_process def: "The covalent attachment of a cofactor to a protein." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018067 name: peptidyl-L-3',4'-dihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4'-dihydroxyphenylalanine (DOPA)." [RESID:AA0146] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4'-dihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0146 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018068 name: peptidyl-L-2',4',5'-topaquinone biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to L-2',4',5'-topaquinone, characteristic of the active site of copper amine oxidases." [RESID:AA0147] synonym: "peptidyl-L-2',4',5'-topaquinone anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-2',4',5'-topaquinone synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0147 is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018069 name: peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a tryptophan residue to tryptophyl quinone to form 4'-(L-tryptophan)-L-tryptophyl quinone, a cofactor found at the active site of methylamine dehydrogenase." [RESID:AA0149] xref: RESID:AA0149 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018070 name: peptidyl-serine phosphopantetheinylation namespace: biological_process def: "The phosphopantetheinylation of peptidyl-serine to form peptidyl-O-phosphopantetheine-L-serine." [RESID:AA0150] xref: RESID:AA0150 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018215 ! protein phosphopantetheinylation [Term] id: GO:0018071 name: NAD(P)-cysteine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-cysteine = nicotinamide + N2-(ADP-D-ribosyl)-L-cysteine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018072 name: peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine biosynthetic process from peptidyl-glutamic acid namespace: biological_process def: "The modification of peptidyl-glutamic acid residues by the covalent attachment of ethanolamine, itself further modified by the addition of a phosphoglycerol unit." [PMID:2569467, RESID:AA0170] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine anabolism from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine formation from peptidyl-glutamic acid" EXACT [] synonym: "peptidyl-L-glutamyl 5-glycerylphosphorylethanolamine synthesis from peptidyl-glutamic acid" EXACT [] xref: RESID:AA0170 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018073 name: protein bromination namespace: biological_process def: "The addition of one or more bromine atoms to an amino acid residue in a protein." [GOC:mah] synonym: "protein amino acid bromination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018074 name: peptidyl-histidine bromination namespace: biological_process def: "The bromination of peptidyl-histidine to form peptidyl-L-bromohistidine; the position of the bromine substitution is unknown." [RESID:AA0173] xref: RESID:AA0173 is_a: GO:0018073 ! protein bromination is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018075 name: peptidyl-phenylalanine bromination namespace: biological_process def: "The bromination of phenylalanine." [RESID:AA0174, RESID:AA0175, RESID:AA0176] xref: RESID:AA0174 xref: RESID:AA0175 xref: RESID:AA0176 is_a: GO:0018073 ! protein bromination is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018076 name: N-terminal peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of the N-terminal lysine of proteins." [GOC:ai] is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018077 name: protein iodination namespace: biological_process def: "The addition of one or more iodine atoms to an amino acid residue in a protein." [GOC:mah] synonym: "protein amino acid iodination" EXACT [GOC:bf] is_a: GO:0018079 ! protein halogenation [Term] id: GO:0018078 name: peptidyl-thyronine iodination namespace: biological_process def: "The iodination of peptidyl-thyronine, formed from tyrosine." [RESID:AA0177, RESID:AA0178] xref: RESID:AA0177 xref: RESID:AA0178 is_a: GO:0018077 ! protein iodination is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018079 name: protein halogenation namespace: biological_process def: "The addition of a halogen to a protein amino acid." [GOC:ai] synonym: "protein amino acid halogenation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0070276 ! halogen metabolic process [Term] id: GO:0018080 name: peptidyl-tryptophan bromination namespace: biological_process def: "The bromination of peptidyl-tryptophan, to form peptidyl-L-6'-bromotryptophan." [RESID:AA0179] xref: RESID:AA0179 is_a: GO:0018073 ! protein bromination is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018081 name: peptide cross-linking via lanthionine or 3-methyl-lanthionine namespace: biological_process def: "The synthesis of (2R,6R)-lanthionine, sn-(2S,6R)-lanthionine or (2S,3S,6R)-3-methyl-lanthionine, forming an intra-polypeptide cross-link between peptidyl-cysteine, and peptidyl-serine or peptidyl-threonine; dehydration of the serine or threonine residue to the alpha,beta-unsaturated amino acid is the first step; a bond then forms between the ethylene (ethene) group thus formed and the sulfur atom of a cysteine, with the inversion of the configuration of the alpha carbon of the serine or threonine occurring during the process." [ISBN:0198547684, RESID:AA0110, RESID:AA0111, RESID:AA0112] synonym: "peptide cross-linking via the thioethers lanthionine or 3-methyl-lanthionine" EXACT [] synonym: "peptide cross-linking via the thiolethers lanthionine or 3-methyl-lanthionine" EXACT [] xref: RESID:AA0110 xref: RESID:AA0111 xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018082 name: peptidyl-(Z)-dehydrobutyrine biosynthetic process from peptidyl-threonine namespace: biological_process def: "The formation of (Z)-dehydrobutyrine by the dehydration of peptidyl-threonine." [RESID:AA0182] synonym: "peptidyl-(Z)-dehydrobutyrine anabolism from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine formation from peptidyl-threonine" EXACT [] synonym: "peptidyl-(Z)-dehydrobutyrine synthesis from peptidyl-threonine" EXACT [] xref: RESID:AA0182 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018083 name: peptidyl-L-3-oxoalanine biosynthetic process from peptidyl-cysteine or peptidyl-serine namespace: biological_process def: "The modification of peptidyl-cysteine or peptidyl-serine to peptidyl-L-3-oxoalanine; characteristic of the active sites of arylsulfatases." [RESID:AA0185] synonym: "peptidyl-L-3-oxoalanine anabolism from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine formation from peptidyl-cysteine or peptidyl-serine" EXACT [] synonym: "peptidyl-L-3-oxoalanine synthesis from peptidyl-cysteine or peptidyl-serine" EXACT [] xref: RESID:AA0185 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018084 name: peptidyl-lactic acid biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of N-terminal peptidyl-serine to lactic acid." [RESID:AA0186] synonym: "peptidyl-lactic acid anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid formation from peptidyl-serine" EXACT [] synonym: "peptidyl-lactic acid synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0186 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018085 name: peptidyl-L-amino acid racemization namespace: biological_process def: "The process of conversion of a L-amino acid into its enantiomer, the corresponding D-amino acid." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification is_a: GO:0018366 ! chiral amino acid racemization [Term] id: GO:0018086 name: obsolete alanine racemization namespace: biological_process alt_id: GO:0018368 def: "OBSOLETE (was not defined before being made obsolete)." [RESID:AA0191] comment: This term was made obsolete because it was replaced with more appropriate terms. synonym: "alanine racemization" EXACT [] is_obsolete: true consider: GO:0019122 [Term] id: GO:0018091 name: peptidyl-asparagine racemization namespace: biological_process alt_id: GO:0018373 alt_id: GO:0019127 def: "The racemization of peptidyl-asparagine." [RESID:AA0196] xref: RESID:AA0196 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018094 name: protein polyglycylation namespace: biological_process def: "The addition of glycyl units covalently bound to the gamma carboxyl group peptidyl-glutamic acid." [RESID:AA0201] xref: RESID:AA0201 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018095 name: protein polyglutamylation namespace: biological_process def: "The addition of one or more alpha-linked glutamyl units to the gamma carboxyl group of peptidyl-glutamic acid." [RESID:AA0202] xref: RESID:AA0202 is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018096 name: peptide cross-linking via S-(2-aminovinyl)-D-cysteine namespace: biological_process def: "The synthesis of (S,Z)-S-(2-aminovinyl)cysteine forming an intra-polypeptide cross-link between serine and cysteine." [RESID:AA0204] xref: RESID:AA0204 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018097 name: protein-chromophore linkage via peptidyl-S-4-hydroxycinnamyl-L-cysteine namespace: biological_process def: "The synthesis of the chromophore S-4-hydroxycinnamyl-L-cysteine." [RESID:AA0207] synonym: "protein amino acid cinnamylation" BROAD [] xref: RESID:AA0207 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018101 name: protein citrullination namespace: biological_process def: "The hydrolysis of peptidyl-arginine to form peptidyl-citrulline." [PMID:23175390, RESID:AA0214] comment: Citrullination is distinct from the formation of the free amino acid citrulline (e.g. as part of the urea cycle). synonym: "deimination" EXACT [Wikipedia:Citrullination] synonym: "peptidyl-citrulline anabolism from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline biosynthetic process from peptidyl-arginine" EXACT [RESID:AA0214] synonym: "peptidyl-citrulline formation from peptidyl-arginine" EXACT [] synonym: "peptidyl-citrulline synthesis from peptidyl-arginine" EXACT [] xref: RESID:AA0214 is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018102 name: peptidyl-arginine hydroxylation to peptidyl-4-hydroxy-L-arginine namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-4-hydroxy-L-arginine." [RESID:AA0215] xref: RESID:AA0215 is_a: GO:0018126 ! protein hydroxylation is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0018103 name: protein C-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a C atom." [GOC:pr, PMID:7947762, RESID:AA0217] synonym: "protein amino acid C-linked glycosylation" EXACT [GOC:bf] xref: RESID:AA0217 is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018104 name: peptidoglycan-protein cross-linking namespace: biological_process def: "The process of covalently linking peptidoglycan (murein) to proteins." [GOC:jsg] is_a: GO:0009252 ! peptidoglycan biosynthetic process [Term] id: GO:0018105 name: peptidyl-serine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine." [RESID:AA0037] xref: RESID:AA0037 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018106 name: peptidyl-histidine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-histidine to form peptidyl-1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine) or peptidyl-3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0035, RESID:AA0036] xref: RESID:AA0035 xref: RESID:AA0036 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018107 name: peptidyl-threonine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine." [RESID:AA0038] xref: RESID:AA0038 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018108 name: peptidyl-tyrosine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-tyrosine to form peptidyl-O4'-phospho-L-tyrosine." [RESID:AA0039] xref: RESID:AA0039 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018109 name: peptidyl-arginine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-arginine to form omega-N-phospho-L-arginine." [RESID:AA0222] xref: RESID:AA0222 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018110 name: histone arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: histone L-arginine + ATP = histone N(omega)-phospho-L-arginine + ADP + 2 H(+)." [GOC:mah] synonym: "histone-arginine kinase activity" EXACT [] xref: EC:2.7.3 is_a: GO:0004054 ! arginine kinase activity is_a: GO:0035173 ! histone kinase activity [Term] id: GO:0018111 name: methionine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = D-methionine." [EC:5.1.1.2, RHEA:12492] xref: EC:5.1.1.2 xref: KEGG:R00655 xref: MetaCyc:METHIONINE-RACEMASE-RXN xref: RHEA:12492 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018112 name: proline racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline = D-proline." [EC:5.1.1.4, RHEA:10680] xref: EC:5.1.1.4 xref: KEGG:R01255 xref: MetaCyc:PROLINE-RACEMASE-RXN xref: RHEA:10680 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018113 name: lysine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = D-lysine." [EC:5.1.1.5] xref: EC:5.1.1.5 xref: MetaCyc:LYSINE-RACEMASE-RXN xref: RHEA:22864 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018114 name: threonine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = D-threonine." [EC:5.1.1.6, RHEA:13913] xref: EC:5.1.1.6 xref: KEGG:R01467 xref: MetaCyc:THREONINE-RACEMASE-RXN xref: RHEA:13913 is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0018115 name: peptidyl-S-diphytanylglycerol diether-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of cysteine to form peptidyl-S-diphytanylglycerol diether-L-cysteine." [PMID:7797461, RESID:AA0223] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diphytanylglycerol diether-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0223 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018116 name: peptidyl-lysine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-adenosine)-L-lysine." [RESID:AA0227] synonym: "peptidyl-lysine adenylation" EXACT [] xref: RESID:AA0227 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018117 name: protein adenylylation namespace: biological_process alt_id: GO:0018176 def: "The addition of an adenylyl group (adenosine 5'-monophosphate; AMP) to a protein amino acid." [GOC:ai, GOC:jsg, GOC:sart, PMID:21607083] synonym: "protein adenylation" EXACT [] synonym: "protein amino acid adenylylation" EXACT [GOC:bf] synonym: "protein AMPylation" EXACT [GOC:jsg, GOC:sart, PMID:21607083] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018118 name: peptidyl-L-cysteine glutathione disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine by covalent addition of glutathione to form peptidyl-L-cysteine glutathione disulfide." [RESID:AA0229] synonym: "peptidyl-L-cysteine glutathione disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine glutathione disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0229 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018119 name: peptidyl-cysteine S-nitrosylation namespace: biological_process def: "The covalent addition of a nitric oxide (NO) group to the sulphur (S) atom of a cysteine residue in a protein, to form peptidyl-S-nitrosyl-L-cysteine." [RESID:AA0230] synonym: "protein S-nitrosylation" EXACT [PMID:20972426] synonym: "S-nitrosylation" EXACT [PMID:20972426] xref: RESID:AA0230 is_a: GO:0017014 ! protein nitrosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018120 name: peptidyl-arginine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-arginine to form omega-N-(ADP-ribosyl)-L-arginine." [RESID:AA0168] xref: RESID:AA0168 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018121 name: NAD(P)-asparagine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-asparagine = nicotinamide + N2-(ADP-D-ribosyl)-L-asparagine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018122 name: peptidyl-asparagine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-asparagine to form peptidyl-N4-(ADP-ribosyl)-L-asparagine." [RESID:AA0231] xref: RESID:AA0231 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018123 name: peptidyl-cysteine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-cysteine to form peptidyl-S-(ADP-ribosyl)-L-cysteine." [RESID:AA0169] xref: RESID:AA0169 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018124 name: peptide cross-linking via 5'-(N6-L-lysine)-L-topaquinone namespace: biological_process def: "The cross-linking of the epsilon-amino group of a peptidyl-lysine with peptidyl-topaquinone, a modified tyrosine residue." [RESID:AA0233] xref: RESID:AA0233 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018125 name: peptidyl-cysteine methylation namespace: biological_process def: "The methylation of peptidyl-cysteine to form peptidyl-S-methyl-L-cysteine." [RESID:AA0234] xref: RESID:AA0234 is_a: GO:0006479 ! protein methylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018126 name: protein hydroxylation namespace: biological_process def: "The addition of a hydroxy group to a protein amino acid." [GOC:ai] synonym: "protein amino acid hydroxylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018127 name: NAD(P)-serine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-serine = nicotinamide + N2-(ADP-D-ribosyl)-L-serine." [EC:2.4.2.-] is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0018128 name: obsolete peptidyl-serine cyclase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "peptidyl-serine cyclase activity" EXACT [] xref: EC:4.2.1 is_obsolete: true [Term] id: GO:0018129 name: peptidyl-oxazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked oxazoline to oxazole." [GOC:mah, PMID:19058272] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018130 name: heterocycle biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heterocyclic compounds, those with a cyclic molecular structure and at least two different atoms in the ring (or rings)." [ISBN:0198547684] synonym: "heterocycle anabolism" EXACT [] synonym: "heterocycle biosynthesis" EXACT [] synonym: "heterocycle formation" EXACT [] synonym: "heterocycle synthesis" EXACT [] is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0018131 name: oxazole or thiazole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oxazole or thiazole, five-membered heterocyclic ring structures containing an oxygen and a sulfur, respectively, in the 1-position and a nitrogen in the 3-position." [CHEBI:35790, CHEBI:48901, GOC:curators] synonym: "oxazole or thiazole anabolism" EXACT [] synonym: "oxazole or thiazole biosynthesis" EXACT [] synonym: "oxazole or thiazole formation" EXACT [] synonym: "oxazole or thiazole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046484 ! oxazole or thiazole metabolic process [Term] id: GO:0018132 name: peptide cross-linking via L-cysteine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [PMID:8895467, RESID:AA0238] xref: RESID:AA0238 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018133 name: peptide cross-linking via L-cysteine oxazolinecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl cysteine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue." [RESID:AA0239] xref: RESID:AA0239 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018134 name: peptide cross-linking via glycine oxazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine cross-link by the condensation of a serine hydroxyl with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0240] xref: RESID:AA0240 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018135 name: obsolete peptidyl-cysteine cyclase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because there is no record of why it was added, and no evidence can be found to suggest that this activity exists. synonym: "peptidyl-cysteine cyclase activity" EXACT [] xref: EC:4.2.1 is_obsolete: true [Term] id: GO:0018136 name: peptidyl-thiazoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reduction of a peptide-linked thiazoline to thiazole." [GOC:mah, PMID:19058272] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018137 name: peptide cross-linking via glycine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl glycine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0241] xref: RESID:AA0241 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018138 name: peptide cross-linking via L-serine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl serine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0242] xref: RESID:AA0242 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018139 name: peptide cross-linking via L-phenylalanine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl phenylalanine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0243] xref: RESID:AA0243 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018207 ! peptidyl-phenylalanine modification [Term] id: GO:0018140 name: peptide cross-linking via L-cysteine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl cysteine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0244] xref: RESID:AA0244 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018141 name: peptide cross-linking via L-lysine thiazolecarboxylic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl cysteine-peptidyl lysine cross-link by the condensation of a cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [RESID:AA0245] xref: RESID:AA0245 is_a: GO:0018157 ! peptide cross-linking via an oxazole or thiazole is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018142 name: protein-DNA covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between DNA and a protein." [GOC:ma] synonym: "DNA-protein covalent cross-linking" EXACT [GOC:mah] is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018143 name: nucleic acid-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between a nucleic acid and a protein." [GOC:ma] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018144 name: RNA-protein covalent cross-linking namespace: biological_process def: "The formation of a covalent cross-link between RNA and a protein." [GOC:ma] is_a: GO:0018143 ! nucleic acid-protein covalent cross-linking [Term] id: GO:0018145 name: protein-DNA covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-serine residue by the formation of O-(phospho-5'-DNA)-L-serine." [RESID:AA0246] synonym: "DNA-protein covalent cross-linking via peptidyl-serine" EXACT [GOC:mah] xref: RESID:AA0246 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018146 name: keratan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keratan sulfate, a glycosaminoglycan with repeat units consisting of beta-1,4-linked D-galactopyranosyl-beta-(1,4)-N-acetyl-D-glucosamine 6-sulfate and with variable amounts of fucose, sialic acid and mannose units; keratan sulfate chains are covalently linked by a glycosidic attachment through the trisaccharide galactosyl-galactosyl-xylose to peptidyl-threonine or serine residues." [ISBN:0198547684, RESID:AA0247] synonym: "keratan sulfate anabolism" EXACT [] synonym: "keratan sulfate biosynthesis" EXACT [] synonym: "keratan sulfate formation" EXACT [] synonym: "keratan sulfate synthesis" EXACT [] synonym: "keratan sulphate biosynthesis" EXACT [] synonym: "keratan sulphate biosynthetic process" EXACT [] xref: RESID:AA0247 is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0042339 ! keratan sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0018147 name: molybdenum incorporation via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide) namespace: biological_process def: "The incorporation of molybdenum into a protein via L-selenocysteinyl molybdenum bis(molybdopterin guanine dinucleotide)." [RESID:AA0248] xref: RESID:AA0248 is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex is_a: GO:0050844 ! peptidyl-selenocysteine modification [Term] id: GO:0018148 name: RNA-protein covalent cross-linking via peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-RNA)-L-tyrosine." [RESID:AA0249] xref: RESID:AA0249 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018149 name: peptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within protein chains." [GOC:jsg] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018150 name: peptide cross-linking via 3-(3'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3-(3'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0250] xref: RESID:AA0250 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018151 name: peptide cross-linking via L-histidyl-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a protein cross-link." [GOC:ai] is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018152 name: peptide cross-linking via 3'-(1'-L-histidyl)-L-tyrosine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-tyrosine to form a 3'-(1'-L-histidyl)-L-tyrosine protein cross-link." [RESID:AA0270] xref: RESID:AA0270 is_a: GO:0018151 ! peptide cross-linking via L-histidyl-L-tyrosine [Term] id: GO:0018153 name: isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glutamine to produce N6-(L-isoglutamyl)-L-lysine." [RESID:AA0124] xref: RESID:AA0124 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018154 name: peptide cross-linking via (2R,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of (2R,6R)-lanthionine (L-lanthionine)." [RESID:AA0110] xref: RESID:AA0110 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018155 name: peptide cross-linking via sn-(2S,6R)-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-serine and peptidyl-cysteine by the synthesis of sn-(2S,6R)-lanthionine (meso-lanthione)." [RESID:AA0111] xref: RESID:AA0111 is_a: GO:0018081 ! peptide cross-linking via lanthionine or 3-methyl-lanthionine is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018156 name: peptide cross-linking via (2S,3S,6R)-3-methyl-lanthionine namespace: biological_process def: "The formation of a protein-protein cross-link between peptidyl-threonine and peptidyl-cysteine by the synthesis of (2S,3S,6R)-3-methyl-lanthionine (3-methyl-L-lanthionine)." [RESID:AA0112] xref: RESID:AA0112 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018157 name: peptide cross-linking via an oxazole or thiazole namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a peptidyl serine-peptidyl glycine, or peptidyl cysteine-peptidyl glycine cross-link by the condensation of the serine hydroxyl or cysteine thiol with the carbonyl of the preceding residue and alpha-beta dehydrogenation." [GOC:jsg] synonym: "peptide heterocycle biosynthesis" RELATED [GOC:mah] synonym: "peptide heterocycle biosynthetic process" RELATED [GOC:mah] synonym: "peptide heterocycle formation" RELATED [GOC:mah] synonym: "peptide heterocycle synthesis" RELATED [GOC:mah] is_a: GO:0018131 ! oxazole or thiazole biosynthetic process is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018158 name: protein oxidation namespace: biological_process def: "The modification of a protein amino acid by oxidation." [GOC:ai] synonym: "protein amino acid oxidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0018159 name: peptidyl-methionine oxidation namespace: biological_process def: "The oxidation of peptidyl-L-methionine to peptidyl-L-methionine sulfone." [RESID:AA0251] xref: RESID:AA0251 is_a: GO:0018158 ! protein oxidation is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018160 name: peptidyl-pyrromethane cofactor linkage namespace: biological_process alt_id: GO:0018354 alt_id: GO:0033035 def: "The covalent binding of a pyrromethane (dipyrrin) cofactor to protein via the sulfur atom of cysteine forming dipyrrolylmethanemethyl-L-cysteine." [CHEBI:30410, RESID:AA0252] synonym: "dipyrromethane cofactor binding" RELATED [GOC:jsg] synonym: "peptidyl-pyrromethane cofactor linkage via dipyrrolylmethanemethyl-L-cysteine" EXACT [GOC:jsg] xref: RESID:AA0252 is_a: GO:0018065 ! protein-cofactor linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018161 name: dipyrrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dipyrrins (pyrromethanes), compounds containing two pyrrole rings linked through a methine, -CH=, group." [http://www.chem.qmw.ac.uk/iupac/class/tetpy.html#03] synonym: "dipyrrin anabolism" EXACT [] synonym: "dipyrrin biosynthesis" EXACT [] synonym: "dipyrrin formation" EXACT [] synonym: "dipyrrin synthesis" EXACT [] synonym: "dipyrromethane biosynthesis" EXACT [] synonym: "dipyrromethane biosynthetic process" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046453 ! dipyrrin metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0018162 name: peptide cross-linking via S-(2-aminovinyl)-3-methyl-D-cysteine namespace: biological_process def: "The formation of a cross-link between peptidyl-cysteine and peptidyl-threonine via the formation of S-(2-aminovinyl)-3-methyl-D-cysteine." [RESID:AA0253] xref: RESID:AA0253 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018163 name: protein-DNA covalent cross-linking via the 5'-end to peptidyl-tyrosine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-tyrosine residue by the formation of O4'-(phospho-5'-DNA)-L-tyrosine." [RESID:AA0254] synonym: "DNA-protein covalent cross-linking via the 5' end to peptidyl-tyrosine" EXACT [GOC:mah] xref: RESID:AA0254 is_a: GO:0045327 ! protein-DNA covalent cross-linking via peptidyl-tyrosine [Term] id: GO:0018164 name: protein-DNA covalent cross-linking via peptidyl-threonine namespace: biological_process def: "The formation of a covalent cross-link between DNA and a peptidyl-threonine residue by the formation of O-(phospho-5'-DNA)-L-threonine." [RESID:AA0255] synonym: "DNA-protein covalent cross-linking via peptidyl-threonine" EXACT [GOC:mah] xref: RESID:AA0255 is_a: GO:0018142 ! protein-DNA covalent cross-linking is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018165 name: peptidyl-tyrosine uridylylation namespace: biological_process def: "The uridylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-uridine)-L-tyrosine, found in glutamine synthetase." [RESID:AA0256] xref: RESID:AA0256 is_a: GO:0018177 ! protein uridylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018166 name: C-terminal protein-tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to the C-terminus of a protein; typically the addition of tyrosine to the C-terminus of detyrosinated alpha-tubulin by the enzyme tubulin-tyrosine ligase." [RESID:AA0257] comment: See also the molecular function term 'tubulin-tyrosine ligase activity ; GO:0004835'. xref: RESID:AA0257 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018322 ! protein tyrosinylation is_a: GO:0018410 ! C-terminal protein amino acid modification [Term] id: GO:0018167 name: protein-phycoerythrobilin linkage via phycoerythrobilin-bis-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrin via phycoerythrobilin-bis-L-cysteine." [RESID:AA0259] xref: RESID:AA0259 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018168 name: protein-phycoerythrobilin linkage via S-phycoerythrobilin-L-cysteine namespace: biological_process def: "The linkage of the chromophore phycoerythrobilin to phycoerythrocyanin via S-phycoerythrobilin-L-cysteine." [RESID:AA0132] xref: RESID:AA0132 is_a: GO:0017011 ! protein-phycoerythrobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018169 name: ribosomal S6-glutamic acid ligase activity namespace: molecular_function def: "Catalysis of the posttranslational transfer of one or more glutamic acid residues to the C-terminus of ribosomal protein S6." [GOC:mah, PMID:2570347] is_a: GO:0070739 ! protein-glutamic acid ligase activity [Term] id: GO:0018170 name: C-terminal peptidyl-polyglutamic acid amidation namespace: biological_process def: "The formation of a C-terminal peptidyl-polyglutamic acid to form a peptidyl-N-L-glutamyl-poly-L-glutamic acid C-terminus." [RESID:AA0261] xref: RESID:AA0261 is_a: GO:0018040 ! C-terminal peptidyl-glutamic acid amidation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018171 name: peptidyl-cysteine oxidation namespace: biological_process def: "The oxidation of peptidyl-cysteine to peptidyl-L-cysteine sulfinic acid or peptidyl-L-cysteine sulfenic acid." [PMID:9586994, RESID:AA0205, RESID:AA0262] xref: RESID:AA0205 xref: RESID:AA0262 is_a: GO:0018158 ! protein oxidation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018172 name: peptidyl-L-3',4',5'-trihydroxyphenylalanine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The modification of protein tyrosine to peptidyl-L-3',4',5'-dihydroxyphenylalanine." [RESID:AA0263] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-L-3',4',5'-trihydroxyphenylalanine synthesis from peptidyl-tyrosine" EXACT [] xref: RESID:AA0263 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018336 ! peptidyl-tyrosine hydroxylation [Term] id: GO:0018173 name: peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-1-thioglycine from other compounds, including peptidyl-glycine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-1-thioglycine synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0265 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process relationship: part_of GO:0015011 ! nickel-tetrapyrrole coenzyme metabolic process [Term] id: GO:0018174 name: protein-heme P460 linkage namespace: biological_process def: "The linkage of protein to heme P460." [RESID:AA0266, RESID:AA0271] synonym: "protein-haem P460 linkage" EXACT [] xref: RESID:AA0266 xref: RESID:AA0271 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018175 name: protein nucleotidylation namespace: biological_process def: "The addition of a nucleotide to a protein amino acid." [GOC:ai] synonym: "protein amino acid nucleotidylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018177 name: protein uridylylation namespace: biological_process def: "The addition of phospho-uridine to a protein amino acid." [GOC:jsg] synonym: "protein amino acid uridylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018178 name: peptidyl-threonine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-threonine to form peptidyl-O-(phospho-5'-adenosine)-L-threonine." [RESID:AA0267] synonym: "peptidyl-threonine adenylation" EXACT [] xref: RESID:AA0267 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018179 name: obsolete peptidyl-cysteine desulfurization namespace: biological_process def: "OBSOLETE. The desulfurization of peptidyl-L-cysteine to yield L-alanine and elemental sulfur; peptidyl-L-cysteine persulfide is an intermediate." [RESID:AA0269] comment: This term was made obsolete because to does not correspond to a real process. synonym: "peptidyl-cysteine desulfurization" EXACT [] synonym: "peptidyl-cysteine desulphurization" EXACT [] xref: RESID:AA0269 is_obsolete: true [Term] id: GO:0018180 name: protein desulfurization namespace: biological_process def: "The removal of a sulfur group from a protein amino acid." [GOC:ai] synonym: "protein amino acid desulfurisation" EXACT [] synonym: "protein amino acid desulfurization" EXACT [GOC:bf] synonym: "protein amino acid desulphurisation" EXACT [] synonym: "protein amino acid desulphurization" EXACT [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018181 name: peptidyl-arginine C5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the carbon 5 (C5) residue to form peptidyl-5-methyl-L-arginine." [GOC:bf, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0272] synonym: "peptidyl-arginine 5-methylation" EXACT [] xref: RESID:AA0272 is_a: GO:0035245 ! peptidyl-arginine C-methylation [Term] id: GO:0018182 name: protein-heme linkage via 3'-L-histidine namespace: biological_process def: "The covalent linkage of heme and a protein via 3'-L-histidine (otherwise known as pi-heme-histidine, pros-heme-histidine)." [RESID:AA0276] synonym: "protein-haem linkage via 3'-L-histidine" EXACT [] xref: RESID:AA0276 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018183 name: obsolete enzyme active site formation via S-selenyl-L-cysteine namespace: biological_process def: "OBSOLETE. The transient selenylation of peptidyl-cysteine to form S-selenyl-L-cysteine." [RESID:AA0277] comment: This term was made obsolete because this structure does not exist. synonym: "enzyme active site formation via S-selenyl-L-cysteine" EXACT [] is_obsolete: true [Term] id: GO:0018184 name: protein polyamination namespace: biological_process def: "The modification of a protein amino acid by polyamination." [GOC:ai] synonym: "protein amino acid polyamination" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018185 name: poly-N-methyl-propylamination namespace: biological_process def: "The modification of peptidyl-lysine by the addition of an N6-propylamino and of propylmethylamino units, forming N6-(propylamino-poly(propylmethylamino)-propyldimethylamine)-L-lysine, typical of the silicate binding protein silaffin." [RESID:AA0278] xref: RESID:AA0278 is_a: GO:0018184 ! protein polyamination is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018186 name: peroxidase-heme linkage namespace: biological_process def: "The covalent linkage of heme to peroxidase." [RESID:AA0279, RESID:AA0280] synonym: "peroxidase-haem linkage" EXACT [] xref: RESID:AA0279 xref: RESID:AA0280 is_a: GO:0017003 ! protein-heme linkage is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0018187 name: molybdenum incorporation via L-cysteinyl molybdopterin guanine dinucleotide namespace: biological_process def: "The incorporation of molybdenum into a protein by L-cysteinyl molybdopterin guanine dinucleotide." [RESID:AA0281] xref: RESID:AA0281 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018188 name: peptidyl-proline di-hydroxylation namespace: biological_process def: "The modification of peptidyl-proline to form trans-2,3-cis-3,4-dihydroxy-L-proline." [RESID:AA0282] xref: RESID:AA0282 is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018189 name: pyrroloquinoline quinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cofactor pyrroloquinoline quinone (PQQ); it is synthesized from a small peptide containing tyrosine and glutamic acid; these amino acids in the peptide are multiply cross-linked and the rest of the peptide is removed." [PMID:7665488, RESID:AA0283] synonym: "coenzyme pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "coenzyme pyrroloquinoline-quinone biosynthetic process" EXACT [] synonym: "PQQ biosynthesis" EXACT [] synonym: "PQQ biosynthetic process" EXACT [] synonym: "pyrroloquinoline quinone anabolism" EXACT [] synonym: "pyrroloquinoline quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline quinone formation" EXACT [] synonym: "pyrroloquinoline quinone synthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthesis" EXACT [] synonym: "pyrroloquinoline-quinone biosynthetic process" EXACT [] xref: RESID:AA0283 is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901663 ! quinone biosynthetic process [Term] id: GO:0018190 name: protein octanoylation namespace: biological_process def: "The modification of a protein amino acid by formation of an ester or amide with octanoic acid." [GOC:jsg] synonym: "protein amino acid octanoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018191 name: peptidyl-serine octanoylation namespace: biological_process def: "The octanoylation of peptidyl-serine to form peptidyl-O3-octanoyl-L-serine, typical of the protein ghrelin." [PMID:10604470, RESID:AA0290] xref: RESID:AA0290 is_a: GO:0018190 ! protein octanoylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018192 name: enzyme active site formation via cysteine modification to L-cysteine persulfide namespace: biological_process def: "The formation of an enzyme active site via modification of peptidyl-cysteine to peptidyl-L-cysteine persulfide." [PMID:11592406, RESID:AA0269] synonym: "enzyme active site formation via L-cysteine persulphide" EXACT [] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098822 ! peptidyl-cysteine modification to L-cysteine persulfide [Term] id: GO:0018193 name: peptidyl-amino acid modification namespace: biological_process def: "The alteration of an amino acid residue in a peptide." [GOC:mah] subset: goslim_yeast is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018194 name: peptidyl-alanine modification namespace: biological_process def: "The modification of peptidyl-alanine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018195 name: peptidyl-arginine modification namespace: biological_process def: "The modification of peptidyl-arginine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018196 name: peptidyl-asparagine modification namespace: biological_process def: "The modification of peptidyl-asparagine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018197 name: peptidyl-aspartic acid modification namespace: biological_process def: "The modification of peptidyl-aspartic acid." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018198 name: peptidyl-cysteine modification namespace: biological_process def: "The modification of peptidyl-cysteine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018199 name: peptidyl-glutamine modification namespace: biological_process def: "The modification of peptidyl-glutamine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018200 name: peptidyl-glutamic acid modification namespace: biological_process def: "The modification of peptidyl-glutamic acid." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018201 name: peptidyl-glycine modification namespace: biological_process def: "The modification of peptidyl-glycine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018202 name: peptidyl-histidine modification namespace: biological_process def: "The modification of peptidyl-histidine." [GOC:ma] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018203 name: peptidyl-isoleucine modification namespace: biological_process def: "The modification of peptidyl-isoleucine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018204 name: peptidyl-leucine modification namespace: biological_process def: "The modification of peptidyl-leucine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018205 name: peptidyl-lysine modification namespace: biological_process def: "The modification of peptidyl-lysine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018206 name: peptidyl-methionine modification namespace: biological_process def: "The modification of peptidyl-methionine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018207 name: peptidyl-phenylalanine modification namespace: biological_process def: "The modification of peptidyl-phenylalanine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018208 name: peptidyl-proline modification namespace: biological_process def: "The modification of peptidyl-proline." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018209 name: peptidyl-serine modification namespace: biological_process def: "The modification of peptidyl-serine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018210 name: peptidyl-threonine modification namespace: biological_process def: "The modification of peptidyl-threonine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018211 name: peptidyl-tryptophan modification namespace: biological_process def: "The chemical alteration of a tryptophan residue in a peptide." [GOC:isa_complete] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018212 name: peptidyl-tyrosine modification namespace: biological_process def: "The modification of peptidyl-tyrosine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018213 name: peptidyl-valine modification namespace: biological_process def: "The modification of peptidyl-valine." [GOC:go_curators] is_a: GO:0018193 ! peptidyl-amino acid modification [Term] id: GO:0018214 name: protein carboxylation namespace: biological_process def: "The addition of a carboxy group to a protein amino acid." [GOC:ai] synonym: "protein amino acid carboxylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018215 name: protein phosphopantetheinylation namespace: biological_process def: "The modification of a protein amino acid by phosphopantetheinylation." [GOC:ai] synonym: "protein amino acid phosphopantetheinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018216 name: peptidyl-arginine methylation namespace: biological_process alt_id: GO:0018017 def: "The addition of a methyl group to an arginine residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0018217 name: peptidyl-aspartic acid phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-aspartic acid." [GOC:jl] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018218 name: peptidyl-cysteine phosphorylation namespace: biological_process def: "The phosphorylation of peptidyl-cysteine to form peptidyl-S-phospho-L-cysteine." [RESID:AA0034] xref: RESID:AA0034 is_a: GO:0006468 ! protein phosphorylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018219 name: peptidyl-cysteine S-acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine to form peptidyl-S-acetyl-L-cysteine." [RESID:AA0056] xref: RESID:AA0056 is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018220 name: peptidyl-threonine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a threonine residue to form peptidyl-O-palmitoyl-L-threonine." [RESID:AA0079] comment: Palmitoylation of a non-terminal threonine residue always occurs on an oxygen (O) atom. synonym: "peptidyl-threonine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0079 is_a: GO:0018210 ! peptidyl-threonine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018221 name: peptidyl-serine palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to an oxygen (O) atom in a serine residue to form peptidyl-O-palmitoyl-L-serine." [RESID:AA0080] comment: Palmitoylation of a non-terminal serine residue always occurs on an oxygen (O) atom. synonym: "peptidyl-serine O-palmitoylation" EXACT [GOC:jsg] xref: RESID:AA0080 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018222 name: peptidyl-L-cysteine methyl disulfide biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-L-cysteine methyl disulfide." [RESID:AA0101] synonym: "peptidyl-L-cysteine methyl disulfide anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulfide synthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthesis from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl disulphide biosynthetic process from peptidyl-cysteine" EXACT [] xref: RESID:AA0101 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018226 name: peptidyl-S-farnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-farnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine; the residue may be found at the first position in the sequence motif C-X-X-(SAQCMT)* where the second and third positions are usually aliphatic." [RESID:AA0102] synonym: "peptidyl-S-farnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-farnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0102 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018227 name: peptidyl-S-12-hydroxyfarnesyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form S-12-hydroxyfarnesyl-L-cysteine; formation of S-farnesycysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CXXX motif and methyl esterification of the farnesylated cysteine." [RESID:AA0103] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-12-hydroxyfarnesyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0103 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018343 ! protein farnesylation [Term] id: GO:0018228 name: peptidyl-S-geranylgeranyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-geranylgeranylcysteine; formation of S-geranylgeranyl-L-cysteine may be coupled with subsequent cleavage of a carboxy-terminal tripeptide for the CAAX motif and methyl esterification of the geranylgeranylated cysteine; methyl esterification but not cleavage occurs for the CXC motif. For the type II geranylgeranyltransferase the residue may be found at the first and final positions in the sequence motif C-X-C* or at the final position in the sequence motif C-C*. These motifs are necessary but not sufficient for modification." [RESID:AA0104] synonym: "peptidyl-S-geranylgeranyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-geranylgeranyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0104 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018344 ! protein geranylgeranylation [Term] id: GO:0018229 name: peptidyl-L-cysteine methyl ester biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of a C-terminal peptidyl-cysteine to form peptidyl-L-cysteine methyl ester." [RESID:AA0105] synonym: "peptidyl-L-cysteine methyl ester anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-L-cysteine methyl ester synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0105 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018351 ! peptidyl-cysteine esterification [Term] id: GO:0018230 name: peptidyl-L-cysteine S-palmitoylation namespace: biological_process def: "The covalent attachment of a palmitoyl group to a sulfur (S) atom within a cysteine residue to form peptidyl-S-palmitoyl-L-cysteine." [RESID:AA0106] comment: Palmitoylation of a non-terminal cysteine residue always occurs on a sulfur (S) atom. synonym: "peptidyl-cysteine S-palmitoylation" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0106 is_a: GO:0018231 ! peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine is_a: GO:0018345 ! protein palmitoylation [Term] id: GO:0018231 name: peptidyl-S-diacylglycerol-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-diacylglycerol-L-cysteine; the oleate and palmitate actually represent mixtures of saturated (generally at 3') and unsaturated (generally at 2') fatty acids." [RESID:AA0107] synonym: "peptidyl-S-diacylglycerol-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-diacylglycerol-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0107 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018232 name: peptide cross-linking via S-(L-isoglutamyl)-L-cysteine namespace: biological_process def: "The modification of peptidyl-glutamine and peptidyl-cysteine to form a S-(L-isoglutamyl)-L-cysteine protein cross-link." [RESID:AA0108] xref: RESID:AA0108 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018199 ! peptidyl-glutamine modification [Term] id: GO:0018233 name: peptide cross-linking via 2'-(S-L-cysteinyl)-L-histidine namespace: biological_process def: "The modification of peptidyl-histidine and peptidyl-cysteine to form a 2'-(S-L-cysteinyl)-L-histidine protein cross-link." [RESID:AA0109] xref: RESID:AA0109 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification [Term] id: GO:0018234 name: peptide cross-linking via 3'-(S-L-cysteinyl)-L-tyrosine namespace: biological_process def: "The thioether cross-linking of a cysteine residue to a tyrosine residue to form 3'-(S-L-cysteinyl)-L-tyrosine, found in galactose oxidase." [RESID:AA0113] xref: RESID:AA0113 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018235 name: peptidyl-lysine carboxylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-carboxy-L-lysine." [RESID:AA0114] xref: RESID:AA0114 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0018237 name: urease activator activity namespace: molecular_function def: "Increases the activity of urease by promoting the incorporation of nickel into the active site." [GOC:mah, PMID:16244137] synonym: "urease activase activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0018238 name: peptidyl-lysine carboxyethylation namespace: biological_process alt_id: GO:0018239 def: "The modification of peptidyl-lysine to form peptidyl-N6-1-carboxyethyl-L-lysine." [RESID:AA0115] synonym: "protein amino acid carboxyethylation" EXACT [] xref: RESID:AA0115 is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018240 name: protein S-linked glycosylation via cysteine namespace: biological_process def: "The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine." [RESID:AA0152] synonym: "protein amino acid S-linked glycosylation via cysteine" EXACT [GOC:bf] xref: RESID:AA0152 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018280 ! protein S-linked glycosylation [Term] id: GO:0018241 name: protein O-linked glycosylation via hydroxylysine namespace: biological_process def: "The glycosylation of protein via the O5 atom of peptidyl-hydroxylysine, forming O5-glycosyl-L-hydroxylysine; the most common form is galactosyl hydroxylysine." [RESID:AA0153] synonym: "protein amino acid O-linked glycosylation via hydroxylysine" EXACT [GOC:bf] xref: RESID:AA0153 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018242 name: protein O-linked glycosylation via serine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-serine, forming O3-glycosyl-L-serine; the most common forms are N-acetylgalactosaminyl, mannosyl, galactosyl, and xylosyl serine." [RESID:AA0154] synonym: "protein amino acid O-linked glycosylation via serine" EXACT [GOC:bf] xref: RESID:AA0154 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018243 name: protein O-linked glycosylation via threonine namespace: biological_process def: "The glycosylation of protein via the O3 atom of peptidyl-threonine, forming O3-glycosyl-L-threonine; the most common forms are N-acetylgalactosaminyl, mannosyl, and galactosyl threonine." [RESID:AA0155] synonym: "protein amino acid O-linked glycosylation via threonine" EXACT [GOC:bf] xref: RESID:AA0155 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018244 name: protein N-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of protein via peptidyl-tryptophan, 1'-glycosyl-L-tryptophan; results in the formation of an (S)-2-amino-3-(1-D-mannopyranosyloxy-1H-indol-3-yl)propanoic acid residue." [RESID:AA0156] synonym: "protein amino acid N-linked glycosylation via tryptophan" EXACT [GOC:bf] xref: RESID:AA0156 is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018245 name: protein O-linked glycosylation via tyrosine namespace: biological_process def: "The glycosylation of protein via the O4' atom of peptidyl-tyrosine, O4'-glycosyl-L-tyrosine; the carbohydrate is glucose, the origin for glycogen." [RESID:AA0157] synonym: "protein amino acid O-linked glycosylation via tyrosine" EXACT [GOC:bf] xref: RESID:AA0157 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018246 name: protein-coenzyme A linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and coenzyme A." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018247 name: protein-phosphoribosyl dephospho-coenzyme A linkage namespace: biological_process def: "The linkage of phosphoribosyl dephospho-coenzyme A to protein via peptidyl-serine, to form O-(phosphoribosyl dephospho-coenzyme A)-L-serine; it is uncertain whether the phosphoribosyl glycosidic attachment to the dephospho-coenzyme A is alpha or beta, and through the 2' or the 3' position." [RESID:AA0167] xref: RESID:AA0167 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018246 ! protein-coenzyme A linkage [Term] id: GO:0018248 name: enzyme active site formation via peptidyl cysteine sulfation namespace: biological_process def: "The formation of an enzyme active site via transient sulfation of peptidyl-cysteine to form S-sulfo-L-cysteine." [RESID:AA0171] synonym: "enzyme active site formation via S-sulpho-L-cysteine" EXACT [] is_a: GO:0018307 ! enzyme active site formation is_a: GO:0098824 ! peptidyl-cysteine sulfation [Term] id: GO:0018249 name: protein dehydration namespace: biological_process def: "The removal of a water group from a protein amino acid." [GOC:ai] synonym: "protein amino acid dehydration" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018250 name: peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine namespace: biological_process def: "The formation of peptidyl-dehydroalanine from either peptidyl-tyrosine by phenyl transfer, or from peptidyl-serine, which is coupled with the formation of 5-imidazolinone by the two neighboring residues, produces an 4-methylidene-imidazole-5-one active site of some amino acid ammonia-lyases; the 4-methylidene-imidazole-5-one, is formed autocatalytically by cyclization and dehydration of the sequence ASG." [RESID:AA0181] synonym: "peptidyl-dehydroalanine anabolism from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine formation from peptidyl-tyrosine or peptidyl-serine" EXACT [] synonym: "peptidyl-dehydroalanine synthesis from peptidyl-tyrosine or peptidyl-serine" EXACT [] xref: RESID:AA0181 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0018251 name: peptidyl-tyrosine dehydrogenation namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-dehydrotyrosine coupled with cyclization of neighboring residues." [RESID:AA0183] comment: See also the biological process terms 'peptide cross-linking via L-seryl-5-imidazolinone glycine ; GO:0018252' and 'peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine ; GO:0019729'. xref: RESID:AA0183 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018249 ! protein dehydration [Term] id: GO:0018252 name: peptide cross-linking via L-seryl-5-imidazolinone glycine namespace: biological_process def: "The formation of the green fluorescent protein chromophore cross-link from the alpha-carboxyl carbon of residue n, a serine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0184] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via L-seryl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018253 name: peptide cross-linking via 5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue n, an alanine, serine or cysteine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with an oxidation of residue n+1 to form an active aldehyde." [RESID:AA0184, RESID:AA0187, RESID:AA0188] synonym: "biosynthesis of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 5-imidazolinone glycine" EXACT [] xref: RESID:AA0184 xref: RESID:AA0187 xref: RESID:AA0188 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018254 name: peptidyl-tyrosine adenylylation namespace: biological_process def: "The adenylylation of peptidyl-tyrosine to form peptidyl-O4'-(phospho-5'-adenosine)-L-tyrosine." [RESID:AA0203] synonym: "peptidyl-tyrosine adenylation" EXACT [] xref: RESID:AA0203 is_a: GO:0018117 ! protein adenylylation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018255 name: peptide cross-linking via S-glycyl-L-cysteine namespace: biological_process def: "The formation of S-(peptidyl-glycyl)-peptidyl-cysteine cross-links by the formation of a thiolester between cysteine and the carboxy-terminal glycine of ubiquitin and other proteins." [GOC:jh2, RESID:AA0206] xref: RESID:AA0206 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018256 name: protein formylation namespace: biological_process def: "The addition of a formyl group to a protein amino acid." [GOC:ai] synonym: "protein amino acid formylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0018257 name: peptidyl-lysine formylation namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-formyl-L-lysine." [RESID:AA0211] xref: RESID:AA0211 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018256 ! protein formylation [Term] id: GO:0018258 name: protein O-linked glycosylation via hydroxyproline namespace: biological_process def: "The glycosylation of proteins via 04 atom of hydroxyproline to form O4-glycosyl-L-hydroxyproline; the most common form is arabinofuranosyl-4-proline." [RESID:AA0212] synonym: "protein amino acid O-linked glycosylation via hydroxyproline" EXACT [GOC:bf] xref: RESID:AA0212 is_a: GO:0006493 ! protein O-linked glycosylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0018259 name: RNA-protein covalent cross-linking via peptidyl-serine namespace: biological_process def: "The formation of a covalent cross-link between RNA and a peptidyl-serine residue by the formation of O-(phospho-5'-5NA)-L-serine." [RESID:AA0213] xref: RESID:AA0213 is_a: GO:0018144 ! RNA-protein covalent cross-linking is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018260 name: protein guanylylation namespace: biological_process def: "The addition of phospho-guanosine to a protein amino acid." [GOC:ai] synonym: "protein amino acid guanylylation" EXACT [GOC:bf] is_a: GO:0018175 ! protein nucleotidylation [Term] id: GO:0018261 name: peptidyl-lysine guanylylation namespace: biological_process def: "The guanylylation of peptidyl-lysine to form peptidyl-N6-(phospho-5'-guanosine)-L-lysine." [RESID:AA0228] xref: RESID:AA0228 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018260 ! protein guanylylation [Term] id: GO:0018262 name: isopeptide cross-linking namespace: biological_process def: "The formation of a covalent cross-link between or within peptide chains, where either the amino group or the carboxyl group, or both, are not attached to the alpha carbon." [GOC:jsg] is_a: GO:0018149 ! peptide cross-linking [Term] id: GO:0018263 name: isopeptide cross-linking via N-(L-isoaspartyl)-L-cysteine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-cysteine to produce N-(L-isoaspartyl)-L-cysteine." [RESID:AA0216] xref: RESID:AA0216 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018264 name: isopeptide cross-linking via N-(L-isoaspartyl)-glycine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-asparagine and peptidyl-glycine to produce N-(L-isoaspartyl)-glycine." [RESID:AA0126] xref: RESID:AA0126 is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018262 ! isopeptide cross-linking [Term] id: GO:0018265 name: GPI anchor biosynthetic process via N-asparaginyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-asparagine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a asparaginyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0158] synonym: "GPI anchor anabolism via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-asparaginyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0158 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018266 name: GPI anchor biosynthetic process via N-aspartyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-aspartic acid ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a aspartyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0159] synonym: "GPI anchor anabolism via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-aspartyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0159 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0018267 name: GPI anchor biosynthetic process via N-cysteinyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-cysteine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a cysteinyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0160] synonym: "GPI anchor anabolism via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-cysteinyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0160 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018268 name: GPI anchor biosynthetic process via N-glycyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-glycine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a glycyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0161] synonym: "GPI anchor anabolism via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-glycyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0161 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0018269 name: GPI anchor biosynthetic process via N-seryl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0162] synonym: "GPI anchor anabolism via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-seryl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0162 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018270 name: GPI anchor biosynthetic process via N-alanyl-glycosylphosphatidylinositolethanolamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a C-terminal peptidyl-alanine ethanolamide-linked glycosylphosphatidylinositol (GPI) anchor following hydrolysis of an alanyl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0163] synonym: "GPI anchor anabolism via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor formation via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] synonym: "GPI anchor synthesis via N-alanyl-glycosylphosphatidylinositolethanolamine" EXACT [] xref: RESID:AA0163 is_a: GO:0006506 ! GPI anchor biosynthetic process is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0018271 name: biotin-protein ligase activity namespace: molecular_function alt_id: GO:0000106 def: "Catalysis of the reaction: ATP + biotin + protein = AMP + diphosphate + biotin-protein." [GOC:mah] synonym: "biotin-apoprotein ligase activity" EXACT [] xref: EC:6.3.4 xref: MetaCyc:BIOTINLIG-RXN xref: reactome:R-HSA-2993447 "HLCS biotinylates 6x(PCCA:PCCB)" xref: reactome:R-HSA-2993799 "HLCS biotinylates 6xMCCC1:6xMCCC2" xref: reactome:R-HSA-2993802 "HLCS biotinylates PC:Mn2+" xref: reactome:R-HSA-2993814 "HLCS biotinylates ACACA:Mn2+" xref: reactome:R-HSA-4167511 "HLCS biotinylates ACACB" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0018272 name: protein-pyridoxal-5-phosphate linkage via peptidyl-N6-pyridoxal phosphate-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-pyridoxal phosphate-L-lysine." [RESID:AA0119] xref: RESID:AA0119 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018352 ! protein-pyridoxal-5-phosphate linkage [Term] id: GO:0018273 name: protein-chromophore linkage via peptidyl-N6-retinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-retinal-L-lysine." [RESID:AA0120] xref: RESID:AA0120 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0018274 name: peptide cross-linking via L-lysinoalanine namespace: biological_process def: "The modification of peptidyl-lysine and peptidyl-serine to form a (2Xi,9S)-L-lysinoalanine cross-link." [RESID:AA0123] xref: RESID:AA0123 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018275 name: N-terminal peptidyl-cysteine acetylation namespace: biological_process alt_id: GO:0017191 def: "The acetylation of the N-terminal cysteine of proteins to form the derivative N-acetyl-L-cysteine." [RESID:AA0043] synonym: "peptidyl-cysteine N-acetylation" EXACT [] xref: RESID:AA0043 is_a: GO:0006474 ! N-terminal protein amino acid acetylation is_a: GO:0018533 ! peptidyl-cysteine acetylation [Term] id: GO:0018276 name: isopeptide cross-linking via N6-glycyl-L-lysine namespace: biological_process def: "The formation of an isopeptide cross-link between peptidyl-lysine and peptidyl-glycine to produce N6-glycyl-L-lysine. This is distinct from the formation of the thiolester intermediate, which occurs during ubiquitination." [RESID:AA0125] comment: See also the biological process term 'peptide cross-linking via S-glycyl-L-cysteine ; GO:0018255'. xref: RESID:AA0125 is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018262 ! isopeptide cross-linking relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0018277 name: protein deamination namespace: biological_process def: "The removal of an amino group from a protein amino acid." [GOC:ai] synonym: "protein amino acid deamination" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018278 name: N-terminal peptidyl-threonine deamination namespace: biological_process def: "The deamination of N-terminal peptidyl-threonine to form peptidyl-2-oxobutanoic acid." [RESID:AA0129] xref: RESID:AA0129 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018279 name: protein N-linked glycosylation via asparagine namespace: biological_process def: "The glycosylation of protein via the N4 atom of peptidyl-asparagine forming N4-glycosyl-L-asparagine; the most common form is N-acetylglucosaminyl asparagine; N-acetylgalactosaminyl asparagine and N4 glucosyl asparagine also occur. This modification typically occurs in extracellular peptides with an N-X-(ST) motif. Partial modification has been observed to occur with cysteine, rather than serine or threonine, in the third position; secondary structure features are important, and proline in the second or fourth positions inhibits modification." [GOC:jsg, RESID:AA0151, RESID:AA0420, RESID:AA0421] synonym: "protein amino acid N-linked glycosylation via asparagine" EXACT [GOC:bf] is_a: GO:0006487 ! protein N-linked glycosylation is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018280 name: protein S-linked glycosylation namespace: biological_process def: "A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via a sulfur atom of a peptidyl-amino-acid such as cysteine or methionine." [GOC:ai, GOC:jsg, GOC:pr] synonym: "protein amino acid S-linked glycosylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation [Term] id: GO:0018281 name: GSI anchor biosynthetic process via N-seryl-glycosylsphingolipidinositolethanolamine namespace: biological_process def: "The formation of a C-terminal peptidyl-serine ethanolamide-linked glycosylsphingolipidinositol (GSI) anchor following hydrolysis of a seryl-peptide bond in the carboxy-terminal region of a membrane-associated protein." [RESID:AA0166] synonym: "GSI anchor anabolism via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor formation via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] synonym: "GSI anchor synthesis via N-seryl-glycosylsphingolipidinositolethanolamine" EXACT [] xref: RESID:AA0166 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0042082 ! GSI anchor biosynthetic process [Term] id: GO:0018282 name: metal incorporation into metallo-sulfur cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including iron, nickel, molybdenum, vanadium, or copper, with one or more bridging (mu-bond) sulfur atoms; amino acids residues in proteins that may ligate the metal sulfur cluster are cysteine, histidine, aspartate, glutamate, serine and cysteine persulfide." [GOC:jsg] synonym: "metal incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! cellular protein modification process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0018283 name: iron incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of iron into a metallo-sulfur cluster." [GOC:ai] synonym: "iron incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018284 name: iron incorporation into protein via tetrakis-L-cysteinyl iron namespace: biological_process def: "The incorporation of iron into a protein via tetrakis-L-cysteinyl iron (there is no exogenous sulfur, so this modification by itself does not produce an iron-sulfur protein)." [RESID:AA0136] xref: RESID:AA0136 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018285 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide namespace: biological_process def: "The incorporation of iron into a 2Fe-2S iron-sulfur cluster via tetrakis-L-cysteinyl diiron disulfide." [RESID:AA0137] synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl diiron disulphide" EXACT [] xref: RESID:AA0137 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018286 name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 3Fe-3S iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide. The three-iron three-sulfur cluster probably does not exist except as an intermediate form." [RESID:AA0138] comment: This term was made obsolete because the three-iron three-sulfur cluster is now thought not to exist except possibly as an intermediate form. synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl triiron trisulfide" EXACT [] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron trisulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018287 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide namespace: biological_process def: "The incorporation of iron into a 3Fe-4S iron-sulfur cluster via tris-L-cysteinyl triiron tetrasulfide." [RESID:AA0139] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl triiron tetrasulphide" EXACT [] xref: RESID:AA0139 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018288 name: iron incorporation into iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tetrakis-L-cysteinyl tetrairon tetrasulfide." [RESID:AA0140] synonym: "iron incorporation into iron-sulphur cluster via tetrakis-L-cysteinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0140 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018289 name: molybdenum incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into a metallo-sulfur cluster." [GOC:ai] synonym: "molybdenum incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018290 name: iron and molybdenum incorporation into iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide namespace: biological_process def: "The incorporation of iron and molybdenum into a Mo-7Fe-8S iron-molybdenum-sulfur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulfide, found in nitrogenase." [RESID:AA0141] synonym: "iron and molybdenum incorporation into iron-molybdenum-sulphur cluster via L-cysteinyl homocitryl molybdenum-heptairon-nonasulphide" EXACT [] xref: RESID:AA0141 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018291 ! molybdenum incorporation into iron-sulfur cluster [Term] id: GO:0018291 name: molybdenum incorporation into iron-sulfur cluster namespace: biological_process def: "The incorporation of molybdenum into an iron-sulfur cluster." [GOC:ai] synonym: "molybdenum incorporation into iron-sulphur cluster" EXACT [] is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018289 ! molybdenum incorporation into metallo-sulfur cluster [Term] id: GO:0018292 name: molybdenum incorporation via L-cysteinyl molybdopterin namespace: biological_process def: "The incorporation of molybdenum into a protein via L-cysteinyl molybdopterin." [RESID:AA0142] xref: RESID:AA0142 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018315 ! molybdenum incorporation into molybdenum-molybdopterin complex [Term] id: GO:0018293 name: protein-FAD linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin-adenine dinucleotide (FAD)." [GOC:ai] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018294 name: protein-FAD linkage via S-(8alpha-FAD)-L-cysteine namespace: biological_process def: "The formation of a protein-FAD linkage via S-(8-alpha-FAD)-L-cysteine." [RESID:AA0143] xref: RESID:AA0143 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018295 name: protein-FAD linkage via 3'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 3'-(8-alpha-FAD)-L-histidine." [RESID:AA0144] xref: RESID:AA0144 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018296 name: protein-FAD linkage via O4'-(8alpha-FAD)-L-tyrosine namespace: biological_process def: "The formation of a protein-FAD linkage via O4'-(8-alpha-FAD)-L-tyrosine." [RESID:AA0145] xref: RESID:AA0145 is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018297 name: protein-FAD linkage via 1'-(8alpha-FAD)-L-histidine namespace: biological_process def: "The formation of a protein-FAD linkage via 1'-(8-alpha-FAD)-L-histidine." [RESID:AA0221] xref: RESID:AA0221 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018293 ! protein-FAD linkage [Term] id: GO:0018298 name: protein-chromophore linkage namespace: biological_process def: "The covalent or noncovalent attachment of a chromophore to a protein." [GOC:ma] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018299 name: iron incorporation into the Rieske iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide namespace: biological_process def: "The incorporation of iron into a Rieske 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl bis-L-histidino diiron disulfide." [RESID:AA0225] synonym: "iron incorporation into the Rieske iron-sulphur cluster via bis-L-cysteinyl bis-L-histidino diiron disulphide" EXACT [] xref: RESID:AA0225 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018300 name: obsolete iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide namespace: biological_process def: "OBSOLETE. The incorporation of iron into a 6Fe-6S cluster by hexakis-L-cysteinyl hexairon hexasulfide." [RESID:AA0226] comment: This term was made obsolete because the prismane 6Fe-6S cluster is now thought not to exist. synonym: "iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl hexairon hexasulfide" EXACT [] synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl hexairon hexasulphide" EXACT [] is_obsolete: true consider: GO:0018198 consider: GO:0018283 [Term] id: GO:0018301 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon namespace: biological_process def: "The incorporation of iron into an iron-sulfur cluster by tris-L-cysteinyl-L-cysteine persulfido-bis-L-glutamato-L-histidino tetrairon." [RESID:AA0268] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-cysteine persulphido-bis-L-glutamato-L-histidino tetrairon" EXACT [] xref: RESID:AA0268 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018302 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulfide." [RESID:AA0284] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N1'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0284 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018303 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulfide." [RESID:AA0285] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-N3'-histidino tetrairon tetrasulphide" EXACT [] xref: RESID:AA0285 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018304 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulfide." [RESID:AA0286] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-aspartato tetrairon tetrasulphide" EXACT [] xref: RESID:AA0286 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018305 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulfide." [RESID:AA0288] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0288 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018306 name: iron incorporation into iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide namespace: biological_process def: "The incorporation of iron into a 4Fe-4S iron-sulfur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulfide." [RESID:AA0289] synonym: "iron incorporation into iron-sulphur cluster via bis-L-cysteinyl-L-N3'-histidino-L-serinyl tetrairon tetrasulphide" EXACT [] xref: RESID:AA0289 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018307 name: enzyme active site formation namespace: biological_process def: "The modification of part of an enzyme to form the active site." [GOC:ai] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018308 name: obsolete enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "OBSOLETE. The transient modification of lysine by pyruvate to form N6-pyruvic acid 2-iminyl-L-lysine, found in the active site of dihydrodipicolinate synthase." [PMID:1463470, RESID:AA0287] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. synonym: "enzyme active site formation via N6-pyruvic acid 2-iminyl-L-lysine" EXACT [] is_obsolete: true [Term] id: GO:0018309 name: protein-FMN linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and flavin mononucleotide (FMN)." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018310 name: protein-FMN linkage via S-(6-FMN)-L-cysteine namespace: biological_process def: "The formation of a protein-FMN linkage via S-(6-FMN)-L-cysteine." [RESID:AA0220] xref: RESID:AA0220 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018309 ! protein-FMN linkage [Term] id: GO:0018311 name: peptidyl-N4-hydroxymethyl-L-asparagine biosynthetic process from peptidyl-asparagine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N4-hydroxymethyl-L-asparagine from other compounds, including peptidyl-asparagine." [RESID:AA0236] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine anabolism from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine formation from peptidyl-asparagine" EXACT [] synonym: "peptidyl-N4-hydroxymethyl-L-asparagine synthesis from peptidyl-asparagine" EXACT [] xref: RESID:AA0236 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0018312 name: peptidyl-serine ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to peptidyl-serine to form peptidyl-O-(ADP-ribosyl)-L-serine." [RESID:AA0237] xref: RESID:AA0237 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018313 name: peptide cross-linking via L-alanyl-5-imidazolinone glycine namespace: biological_process def: "The formation of a protein active site cross-link from the alpha-carboxyl carbon of residue N, an alanine, to the alpha-amino nitrogen of residue N+2, a glycine, coupled with the formation of a double bond to the alpha-amino nitrogen of residue N+1 which loses one hydrogen, and the loss of a molecule of water." [RESID:AA0187] xref: RESID:AA0187 is_a: GO:0018194 ! peptidyl-alanine modification is_a: GO:0018253 ! peptide cross-linking via 5-imidazolinone glycine [Term] id: GO:0018314 name: obsolete protein-pyrroloquinoline-quinone linkage namespace: biological_process def: "OBSOLETE. The covalent cross-linking of pyrroloquinoline-quinone to peptidyl-glutamic acid and peptidyl-tyrosine." [PMID:7665488, RESID:AA0283] synonym: "protein-pyrroloquinoline-quinone linkage" EXACT [] is_obsolete: true replaced_by: GO:0006464 [Term] id: GO:0018315 name: molybdenum incorporation into molybdenum-molybdopterin complex namespace: biological_process alt_id: GO:0042041 def: "The incorporation of molybdenum into a molybdenum-molybdopterin complex." [GOC:ai] synonym: "molybdenum incorporation into metallo-pterin complex" EXACT [] is_a: GO:0042040 ! metal incorporation into metallo-molybdopterin complex [Term] id: GO:0018316 name: peptide cross-linking via L-cystine namespace: biological_process def: "The oxidation of two peptidyl-cysteine residues to form a peptidyl-L-cystine (dicysteine) in which segments of peptide chain are linked by a disulfide bond; the cross-link may be between different or the same peptide chain." [RESID:AA0025] xref: RESID:AA0025 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018317 name: protein C-linked glycosylation via tryptophan namespace: biological_process def: "The glycosylation of a carbon atom of a peptidyl-tryptophan residue." [GOC:ai] synonym: "protein amino acid C-linked glycosylation via tryptophan" EXACT [GOC:bf] is_a: GO:0018103 ! protein C-linked glycosylation is_a: GO:0018211 ! peptidyl-tryptophan modification [Term] id: GO:0018320 name: enzyme active site formation via S-methyl-L-cysteine namespace: biological_process def: "The transient methylation of peptidyl-cysteine to form S-methyl-L-cysteine." [RESID:AA0234] xref: RESID:AA0234 is_a: GO:0018125 ! peptidyl-cysteine methylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018321 name: protein glucuronylation namespace: biological_process def: "The modification of a protein by amino acid glucuronylation, the addition of a glucuronate group, the uronic acid derived from glucose." [GOC:ai, GOC:pr] synonym: "protein amino acid glucuronylation" EXACT [GOC:bf] is_a: GO:0006486 ! protein glycosylation is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0018322 name: protein tyrosinylation namespace: biological_process def: "The addition of a tyrosine molecule to a protein amino acid." [GOC:ai] synonym: "protein amino acid tyrosinylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018323 name: enzyme active site formation via L-cysteine sulfinic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfinic acid." [RESID:AA0262] synonym: "enzyme active site formation via L-cysteine sulphinic acid" EXACT [] xref: RESID:AA0262 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018324 name: enzyme active site formation via L-cysteine sulfenic acid namespace: biological_process def: "The oxidation of peptidyl-cysteine to form peptidyl-L-cysteine sulfenic acid, found in the active site of NADH peroxidase, nitrile hydratase, and peptide methionine sulfoxide reductase." [PMID:2501303, RESID:AA0205] synonym: "enzyme active site formation via L-cysteine sulphenic acid" EXACT [] xref: RESID:AA0205 is_a: GO:0018171 ! peptidyl-cysteine oxidation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018325 name: enzyme active site formation via S-phospho-L-cysteine namespace: biological_process def: "The transient phosphorylation of peptidyl-cysteine to form S-phospho-L-cysteine." [RESID:AA0034] xref: RESID:AA0034 is_a: GO:0018218 ! peptidyl-cysteine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018326 name: enzyme active site formation via S-acetyl-L-cysteine namespace: biological_process def: "The transient acetylation of peptidyl-cysteine to form S-acetyl-L-cysteine." [RESID:AA0056] xref: RESID:AA0056 is_a: GO:0018219 ! peptidyl-cysteine S-acetylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018327 name: enzyme active site formation via 1'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 1'-phospho-L-histidine (otherwise known as tau-phosphohistidine, tele-phosphohistidine)." [RESID:AA0035] xref: RESID:AA0035 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018328 name: enzyme active site formation via 3'-phospho-L-histidine namespace: biological_process def: "The transient phosphorylation of peptidyl-histidine to form 3'-phospho-L-histidine (otherwise known as pi-phosphohistidine, pros-phosphohistidine)." [RESID:AA0036] xref: RESID:AA0036 is_a: GO:0018106 ! peptidyl-histidine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018329 name: enzyme active site formation via N6-(phospho-5'-adenosine)-L-lysine namespace: biological_process def: "The transient adenylylation of lysine to form N6-(phospho-5'-adenosine)-L-lysine, found in the active site of DNA ligase and RNA ligase." [RESID:AA0227] xref: RESID:AA0227 is_a: GO:0018116 ! peptidyl-lysine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018330 name: enzyme active site formation via N6-(phospho-5'-guanosine)-L-lysine namespace: biological_process def: "The transient guanylylation of lysine to form N6-(phospho-5'-guanosine)-L-lysine, found in the guanylyltransferase active site of mRNA capping enzyme." [RESID:AA0228] xref: RESID:AA0228 is_a: GO:0018261 ! peptidyl-lysine guanylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018331 name: enzyme active site formation via O-phospho-L-serine namespace: biological_process def: "The transient phosphorylation of peptidyl-serine to form O-phospho-L-serine." [RESID:AA0037] xref: RESID:AA0037 is_a: GO:0018105 ! peptidyl-serine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018332 name: enzyme active site formation via O-(phospho-5'-adenosine)-L-threonine namespace: biological_process def: "The transient adenylylation of threonine to form N6-(phospho-5'-adenosine)-L-threonine, found in the active site of bovine phosphodiesterase I." [RESID:AA0267] xref: RESID:AA0267 is_a: GO:0018178 ! peptidyl-threonine adenylylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018333 name: enzyme active site formation via O-phospho-L-threonine namespace: biological_process def: "The transient phosphorylation of peptidyl-threonine to form O-phospho-L-threonine." [RESID:AA0038] xref: RESID:AA0038 is_a: GO:0018107 ! peptidyl-threonine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018334 name: enzyme active site formation via O4'-phospho-L-tyrosine namespace: biological_process def: "The transient phosphorylation of peptidyl-tyrosine to form O-phospho-L-tyrosine." [RESID:AA0039] xref: RESID:AA0039 is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018335 name: protein succinylation namespace: biological_process def: "The modification of a protein by the addition of a succinyl group (CO-CH2-CH2-CO) to an amino acid residue." [CHEBI:37952, GOC:bf] synonym: "protein amino acid succinylation" EXACT [GOC:bf] is_a: GO:0043543 ! protein acylation [Term] id: GO:0018336 name: peptidyl-tyrosine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-tyrosine to form peptidyl-dihydroxyphenylalanine." [GOC:ai] is_a: GO:0018126 ! protein hydroxylation [Term] id: GO:0018337 name: obsolete enzyme active site formation via L-2',4',5'-topaquinone namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because this process does not occur: the modification occurs before it can be an active site. synonym: "enzyme active site formation via L-2',4',5'-topaquinone" EXACT [] is_obsolete: true [Term] id: GO:0018338 name: obsolete protein amino acid cinnamylation namespace: biological_process def: "OBSOLETE. The modification of a protein amino acid by cinnamylation." [GOC:ai] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "protein amino acid cinnamylation" EXACT [] is_obsolete: true consider: GO:0018097 [Term] id: GO:0018339 name: peptidyl-L-beta-methylthioaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid, typical of bacterial ribosomal protein S12." [RESID:AA0232] synonym: "peptidyl-aspartic acid methylthiolation" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-L-beta-methylthioaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0232 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018340 name: peptidyl-O-(sn-1-glycerophosphoryl)-L-serine biosynthetic process from peptidyl-serine namespace: biological_process def: "The modification of peptidyl-serine to peptidyl-O-(sn-1-glycerophosphoryl)-L-serine." [RESID:AA0264] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine anabolism from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine formation from peptidyl-serine" EXACT [] synonym: "peptidyl-O-(sn-1-glycerophosphoryl)-L-serine synthesis from peptidyl-serine" EXACT [] xref: RESID:AA0264 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018341 name: peptidyl-lysine modification to peptidyl-N6-pyruvic acid 2-iminyl-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form peptidyl-N6-pyruvic acid 2-iminyl-L-lysine." [PSI-MOD:00292] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine anabolism" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthesis" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine biosynthetic process" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine formation" EXACT [] synonym: "peptidyl-N6-pyruvic acid 2-iminyl-L-lysine synthesis" EXACT [] is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018342 name: protein prenylation namespace: biological_process alt_id: GO:0018346 def: "The covalent attachment of a prenyl group to a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:di, ISBN:0198506732] synonym: "C-terminal protein prenylation" NARROW [] synonym: "protein amino acid prenylation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0097354 ! prenylation [Term] id: GO:0018343 name: protein farnesylation namespace: biological_process alt_id: GO:0018347 def: "The covalent attachment of a farnesyl group to a protein." [GOC:jl] synonym: "C-terminal protein farnesylation" NARROW [] synonym: "protein amino acid farnesylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018344 name: protein geranylgeranylation namespace: biological_process alt_id: GO:0018348 def: "The covalent attachment of a geranylgeranyl group to a protein." [GOC:jl] synonym: "C-terminal protein geranylgeranylation" NARROW [] synonym: "protein amino acid geranylgeranylation" EXACT [GOC:bf] is_a: GO:0018342 ! protein prenylation [Term] id: GO:0018345 name: protein palmitoylation namespace: biological_process alt_id: GO:0018318 alt_id: GO:0018349 def: "The covalent attachment of a palmitoyl group to a protein." [GOC:jl, PMID:15520806] synonym: "protein amino acid palmitoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018350 name: protein esterification namespace: biological_process def: "The addition of an ester group to a protein amino acid." [GOC:ai] synonym: "protein amino acid esterification" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018351 name: peptidyl-cysteine esterification namespace: biological_process def: "The addition of an ester group to a cysteine residue in a protein." [GOC:mah] is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018352 name: protein-pyridoxal-5-phosphate linkage namespace: biological_process def: "The formation of a linkage between a protein amino acid and pyridoxal-5-phosphate." [GOC:mah] is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0018353 name: protein-phycocyanobilin linkage via S-phycocyanobilin-L-cysteine namespace: biological_process alt_id: GO:0018380 def: "The linkage of the chromophore phycocyanobilin to phycocyanin or allophycocyanin via S-phycocyanobilin-L-cysteine." [RESID:AA0131] xref: RESID:AA0131 is_a: GO:0017009 ! protein-phycocyanobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018355 name: protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine namespace: biological_process def: "The formation of a protein-phosphoribosyl dephospho-coenzyme A linkage via O-(phosphoribosyl dephospho-coenzyme A)-L-serine." [RESID:AA00167] is_a: GO:0018247 ! protein-phosphoribosyl dephospho-coenzyme A linkage [Term] id: GO:0018356 name: protein-phycobiliviolin linkage via S-phycobiliviolin-L-cysteine namespace: biological_process alt_id: GO:0018382 def: "The linkage of the chromophore phycobiliviolin to phycoerythrocyanin via S-phycobiliviolin-L-cysteine." [RESID:AA0258] xref: RESID:AA0258 is_a: GO:0017008 ! protein-phycobiliviolin linkage [Term] id: GO:0018357 name: protein-phycourobilin linkage via phycourobilin-bis-L-cysteine namespace: biological_process alt_id: GO:0018383 def: "The linkage of the chromophore phycourobilin to phycoerythrins via phycourobilin-bis-L-cysteine." [RESID:AA0260] xref: RESID:AA0260 is_a: GO:0017010 ! protein-phycourobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018358 name: protein-phytochromobilin linkage via S-phytochromobilin-L-cysteine namespace: biological_process alt_id: GO:0018381 def: "The linkage of the chromophore phytochromobilin to phycocyanin or allophycocyanin via S-phytochromobilin-L-cysteine." [RESID:AA0133] xref: RESID:AA0133 is_a: GO:0017012 ! protein-phytochromobilin linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018359 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-tyrosine namespace: biological_process alt_id: GO:0018385 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-tyrosine." [RESID:AA0266] synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-tyrosine" EXACT [] xref: RESID:AA0266 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0018360 name: protein-heme P460 linkage via heme P460-bis-L-cysteine-L-lysine namespace: biological_process alt_id: GO:0018384 def: "The linkage of protein to heme P460 via heme P460-bis-L-cysteine-L-lysine." [RESID:AA0271] synonym: "protein-haem P460 linkage via haem P460-bis-L-cysteine-L-lysine" EXACT [] xref: RESID:AA0271 is_a: GO:0018174 ! protein-heme P460 linkage is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018361 name: peptidyl-glutamine 2-methylation namespace: biological_process def: "The methylation of glutamine to form 2-methyl-L-glutamine." [http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0273] xref: RESID:AA0273 is_a: GO:0018364 ! peptidyl-glutamine methylation [Term] id: GO:0018362 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester namespace: biological_process alt_id: GO:0019924 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester." [RESID:AA0279] synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester" EXACT [] xref: RESID:AA0279 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018363 name: peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium namespace: biological_process alt_id: GO:0019925 def: "The covalent linkage of heme to peroxidase via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium." [RESID:AA0280] synonym: "peroxidase-haem linkage via dihydroxyhaem-L-aspartyl ester-L-glutamyl ester-L-methionine sulfonium" EXACT [] synonym: "peroxidase-heme linkage via dihydroxyheme-L-aspartyl ester-L-glutamyl ester-L-methionine sulphonium" EXACT [] xref: RESID:AA0280 is_a: GO:0018186 ! peroxidase-heme linkage is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018206 ! peptidyl-methionine modification [Term] id: GO:0018364 name: peptidyl-glutamine methylation namespace: biological_process def: "The addition of a methyl group to a glutamine residue in a protein." [GOC:mah] is_a: GO:0006479 ! protein methylation [Term] id: GO:0018365 name: protein-serine epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (protein)-L-serine = (protein)-D-serine." [EC:5.1.1.16] synonym: "protein-serine racemase activity" EXACT [EC:5.1.1.16] xref: EC:5.1.1.16 xref: MetaCyc:5.1.1.16-RXN is_a: GO:0016855 ! racemase and epimerase activity, acting on amino acids and derivatives [Term] id: GO:0018366 name: chiral amino acid racemization namespace: biological_process def: "The formation of a mixture of the two possible enantiomers from the D- or L-enantiomer of a chiral amino acid." [GOC:jsg, ISBN:0198506732] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0018367 name: obsolete free L-amino acid racemization namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is not clear that this process occurs. synonym: "free L-amino acid racemization" EXACT [] is_obsolete: true consider: GO:0006520 [Term] id: GO:0018376 name: peptidyl-asparagine hydroxylation to form L-erythro-beta-hydroxyasparagine namespace: biological_process def: "The hydroxylation of peptidyl-asparagine to form peptidyl-L-erythro-beta-hydroxyasparagine; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0026] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. xref: RESID:AA0026 is_a: GO:0042265 ! peptidyl-asparagine hydroxylation [Term] id: GO:0018377 name: protein myristoylation namespace: biological_process alt_id: GO:0018319 def: "The covalent attachment of a myristoyl group to a protein." [GOC:ai] synonym: "protein amino acid myristoylation" EXACT [GOC:bf] is_a: GO:0006497 ! protein lipidation is_a: GO:0043543 ! protein acylation [Term] id: GO:0018378 name: cytochrome c-heme linkage via heme-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-L-cysteine." [RESID:AA0135] synonym: "cytochrome c-haem linkage via haem-L-cysteine" EXACT [] xref: RESID:AA0135 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018379 name: cytochrome c-heme linkage via heme-bis-L-cysteine namespace: biological_process def: "The linkage of cytochromes and other heme proteins to heme via heme-bis-L-cysteine." [RESID:AA0134] synonym: "cytochrome c-haem linkage via haem-bis-L-cysteine" EXACT [] xref: RESID:AA0134 is_a: GO:0018063 ! cytochrome c-heme linkage is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018386 name: N-terminal peptidyl-cysteine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-cysteine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal cysteine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-cysteine." [RESID:AA0274] xref: RESID:AA0274 is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018387 name: N-terminal peptidyl-amino acid deamination to pyruvic acid namespace: biological_process def: "The oxidative deamination of N-terminal peptidyl-cysteine, or peptidyl-serine, to form pyruvic acid with an amide bond between its 1-carboxyl group and the N-terminal residue." [RESID:AA0127] xref: RESID:AA0127 is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018388 name: N-terminal peptidyl-valine condensation with pyruvate to form N-pyruvic acid 2-iminyl-L-valine namespace: biological_process def: "The condensation of pyruvate through the 2-oxo group with the N-terminal valine of proteins to form the derivative N-pyruvic acid 2-iminyl-L-valine." [RESID:AA0275] xref: RESID:AA0275 is_a: GO:0018213 ! peptidyl-valine modification is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0018389 name: N-terminal peptidyl-valine deamination namespace: biological_process def: "The deamination of the N-terminal valine residue of a protein to form isobutyrate." [GOC:ma, GOC:mah] is_a: GO:0018058 ! N-terminal protein amino acid deamination, from amino carbon [Term] id: GO:0018390 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid or peptidyl-glutamine to form the derivative glutamic acid 5-methyl ester." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from peptidyl-glutamic acid or peptidyl-glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018442 ! peptidyl-glutamic acid esterification [Term] id: GO:0018391 name: C-terminal peptidyl-glutamic acid tyrosinylation namespace: biological_process def: "The ATP-dependent addition of a tyrosine residue to a glutamic acid residue at the C-terminus of a protein." [GOC:mah] is_a: GO:0018166 ! C-terminal protein-tyrosinylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018392 name: glycoprotein 3-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP-L-fucose = N(4)-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-[alpha-L-fucosyl-(1->3)]-N-acetyl-beta-D-glucosaminyl}-L-asparagine + GDP + H(+)." [EC:2.4.1.214, RHEA:24444] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fuc-alpha-1->6-GlcNAc)-Asn-peptide) alpha-1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6-GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-fucose:beta-N-acetylglucosamine (Fuc to (Fucalpha1->6GlcNAc)-Asn-peptide) alpha1->3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:Asn-linked GlcNAc alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha1,3-fucosyltransferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:asparagine-linked N-acetylglucosamine alpha(1,3)-fucosyltransferase activity" EXACT [] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] synonym: "GDP-L-fucose:glycoprotein (L-fucose to asparagine-linked N-acetylglucosamine of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 3-alpha-L-fucosyl-transferase activity" EXACT [EC:2.4.1.214] xref: EC:2.4.1.214 xref: KEGG:R06015 xref: MetaCyc:2.4.1.214-RXN xref: RHEA:24444 is_a: GO:0046920 ! alpha-(1->3)-fucosyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0018393 name: internal peptidyl-lysine acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal lysine residue in a protein." [GOC:mah] is_a: GO:0006475 ! internal protein amino acid acetylation is_a: GO:0018394 ! peptidyl-lysine acetylation [Term] id: GO:0018394 name: peptidyl-lysine acetylation namespace: biological_process def: "The acetylation of peptidyl-lysine." [GOC:mah] is_a: GO:0006473 ! protein acetylation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018395 name: peptidyl-lysine hydroxylation to 5-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-5-hydroxy-L-lysine." [RESID:AA0028] xref: RESID:AA0028 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018396 name: peptidyl-lysine hydroxylation to 4-hydroxy-L-lysine namespace: biological_process def: "The hydroxylation of peptidyl-lysine to peptidyl-4-hydroxy-L-lysine." [RESID:AA0235] xref: RESID:AA0235 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0018397 name: peptidyl-phenylalanine bromination to L-2'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-2'-bromophenylalanine." [RESID:AA0174] xref: RESID:AA0174 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018398 name: peptidyl-phenylalanine bromination to L-3'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-3'-bromophenylalanine." [RESID:AA0175] xref: RESID:AA0175 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018399 name: peptidyl-phenylalanine bromination to L-4'-bromophenylalanine namespace: biological_process def: "The bromination of peptidyl-phenylalanine to form L-4'-bromophenylalanine." [RESID:AA0176] xref: RESID:AA0176 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0018075 ! peptidyl-phenylalanine bromination [Term] id: GO:0018400 name: peptidyl-proline hydroxylation to 3-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 3-hydroxy-L-proline; catalyzed by procollagen-proline 3-dioxygenase." [RESID:AA0029] comment: See also the molecular function term 'procollagen-proline 3-dioxygenase activity ; GO:0019797'. xref: RESID:AA0029 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018401 name: peptidyl-proline hydroxylation to 4-hydroxy-L-proline namespace: biological_process def: "The modification of peptidyl-proline to form 4-hydroxy-L-proline; catalyzed by procollagen-proline,2-oxoglutarate-4-dioxygenase." [RESID:AA0030] comment: See also the molecular function term 'procollagen-proline 4-dioxygenase activity ; GO:0004656'. xref: RESID:AA0030 is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0019511 ! peptidyl-proline hydroxylation [Term] id: GO:0018402 name: protein-chondroitin sulfate linkage via chondroitin sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Chondroitin sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0208] synonym: "protein-chondroitin sulphate linkage via chondroitin sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0208 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0018403 name: protein-dermatan sulfate linkage via dermatan 4-sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Dermatan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [PMID:7338506, RESID:AA0209] synonym: "protein-dermatan sulphate linkage via dermatan 4-sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0209 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018404 name: protein-heparan sulfate linkage via heparan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine namespace: biological_process def: "Heparan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and serine residues." [RESID:AA0210] synonym: "protein-heparan sulphate linkage via heparan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-serine" EXACT [] xref: RESID:AA0210 is_a: GO:0018209 ! peptidyl-serine modification [Term] id: GO:0018405 name: protein-keratan sulfate linkage via keratan sulfate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine namespace: biological_process def: "Keratan sulfate components are covalently linked to a core glycoprotein via O-glycosidic linkages between xylose and threonine residues." [RESID:AA0247] synonym: "protein-keratan sulphate linkage via keratan sulphate D-glucuronyl-D-galactosyl-D-galactosyl-D-xylosyl-L-threonine" EXACT [] xref: RESID:AA0247 is_a: GO:0018210 ! peptidyl-threonine modification [Term] id: GO:0018406 name: protein C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan namespace: biological_process alt_id: GO:0032004 def: "The glycosylation of a peptidyl-tryptophan residue by the transfer of alpha-mannopyranose from dolichyl-activated mannose to the indole ring." [PMID:7947762, PMID:9450955, RESID:AA0217] synonym: "protein amino acid C-linked glycosylation via 2'-alpha-mannosyl-L-tryptophan" EXACT [GOC:bf] synonym: "protein amino acid C-linked mannosylation" EXACT [] xref: RESID:AA0217 is_a: GO:0018317 ! protein C-linked glycosylation via tryptophan is_a: GO:0035268 ! protein mannosylation [Term] id: GO:0018407 name: peptidyl-thyronine iodination to form 3',3'',5'-triiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5'-triiodo-L-thyronine (triiodothyronine)." [RESID:AA0177] synonym: "peptidyl-thyronine iodination to form triiodothyronine" BROAD [] xref: RESID:AA0177 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018408 name: peptidyl-thyronine iodination to form 3',3'',5',5''-tetraiodo-L-thyronine namespace: biological_process def: "The iodination of peptidyl-thyronine to form peptidyl-3',3'',5',5''-tetraiodo-L-thyronine (L-thyroxine)." [RESID:AA0178] xref: RESID:AA0178 is_a: GO:0018078 ! peptidyl-thyronine iodination [Term] id: GO:0018410 name: C-terminal protein amino acid modification namespace: biological_process def: "The alteration of the C-terminal amino acid residue in a protein." [GOC:mah] synonym: "peptide or protein carboxyl-terminal blocking" RELATED [] synonym: "peptide/protein carboxyl-terminal blocking" RELATED [] is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0018411 name: protein glucuronidation namespace: biological_process def: "The modification of a protein by amino acid glucuronidation." [GOC:ai] synonym: "protein amino acid glucuronidation" EXACT [GOC:bf] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0018412 name: protein O-glucuronidation namespace: biological_process def: "The modification of a protein by glucuronidation on an amino acid oxygen atom." [GOC:mah] synonym: "protein amino acid O-glucuronidation" EXACT [GOC:bf] is_a: GO:0018411 ! protein glucuronidation [Term] id: GO:0018413 name: peptidyl-serine O-glucuronidation namespace: biological_process def: "The O-glucuronidation of peptidyl-serine to form peptidyl-O3-D-glucuronyl-L-serine." [RESID:AA0291] xref: RESID:AA0291 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018412 ! protein O-glucuronidation [Term] id: GO:0018414 name: nickel incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of nickel into a metallo-sulfur cluster." [GOC:ai] synonym: "nickel incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018415 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018416 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido bis-L-glutamato L-histidino nickel triiron disulfide trioxide." [RESID:AA0292] synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido bis-L-glutamato L-histidino nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0292 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018417 name: iron incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of iron into a 3Fe-2S cluster by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] synonym: "iron incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0293 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0018418 name: nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide namespace: biological_process def: "The incorporation of nickel into a 3Fe-2S complex by tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide." [RESID:AA0293] synonym: "nickel incorporation into iron-sulphur cluster via tris-L-cysteinyl L-cysteine persulphido L-glutamato L-histidino L-serinyl nickel triiron disulphide trioxide" EXACT [] xref: RESID:AA0 is_a: GO:0016226 ! iron-sulfur cluster assembly is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018414 ! nickel incorporation into metallo-sulfur cluster [Term] id: GO:0018419 name: protein catenane formation namespace: biological_process def: "The aggregation, arrangement and bonding together of a protein structure comprising two or more rings that are interlocked but not covalently joined; resembling the links of a chain." [ISBN:0198506732] is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0018420 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine namespace: biological_process def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018196 ! peptidyl-asparagine modification is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0018421 name: UDP-N-acetylglucosamine:serine-protein N-acetylglucosamine-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of N-acetylglucosamine-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:9353330] xref: EC:2.7.8 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018422 name: GDP-mannose:serine-protein mannose-1-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of mannose-1-phosphate to a serine residue in a protein." [GOC:mah, PMID:10037765] xref: EC:2.7.8 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0018423 name: protein C-terminal leucine carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-leucine = S-adenosyl-L-homocysteine + protein L-leucine methyl ester. This modification occurs only at the oxygen atoms of the free alpha carboxyl group of a leucine residue at the C-terminus of the protein." [PMID:8514774] synonym: "protein phosphatase methyltransferase activity" NARROW [] synonym: "protein-leucine O-methyltransferase activity" EXACT [] xref: reactome:R-HSA-8856945 "PP2A methylation by LCMT1" is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018424 name: peptidyl-glutamic acid poly-ADP-ribosylation namespace: biological_process def: "This modification produces peptidyl-glutamic acid poly-ADP-ribose found in a number of nuclear proteins under certain conditions including the repair of single strand DNA breaks. The activated form of the generating enzyme poly(ADP-ribose) polymerase is itself modified in this way." [RESID:AA0295] xref: RESID:AA0295 is_a: GO:0006471 ! protein ADP-ribosylation is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0018425 name: O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(N-acetylglucosamine-1-phosphoryl)-L-serine. The recovery of O-phosphorylserine from acid hydrolysates suggests N-acetylglucosamine-1-phosphate residues are esterified to peptidyl serines through phosphoester bonds." [RESID:AA0296] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(N-acetylglucosamine-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0296 is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046349 ! amino sugar biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0018426 name: O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine. The polypeptide backbones of glycoproteins and mucin-like proteoglycans are extensively modified with a complex array of phosphoglycan chains that are linked to Ser/Thr-rich domains via a common Man-alpha1-PO4-Ser linkage." [RESID:AA0297] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine anabolism" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine biosynthesis" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine formation" EXACT [] synonym: "O3-(phosphoglycosyl-D-mannose-1-phosphoryl)-L-serine synthesis" EXACT [] xref: RESID:AA0297 is_a: GO:0042077 ! protein phosphate-linked glycosylation via serine [Term] id: GO:0018427 name: copper incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of copper into a metallo-sulfur cluster." [GOC:ai] synonym: "copper incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0018282 ! metal incorporation into metallo-sulfur cluster [Term] id: GO:0018428 name: copper incorporation into copper-sulfur cluster namespace: biological_process def: "The incorporation of copper into a copper-sulfur cluster." [GOC:ai] synonym: "copper incorporation into copper-sulphur cluster" EXACT [] is_a: GO:0018427 ! copper incorporation into metallo-sulfur cluster [Term] id: GO:0018429 name: copper incorporation into copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide namespace: biological_process def: "The incorporation of copper into a 4Cu-S copper-sulfur cluster via heptakis-L-histidino tetracopper mu4-sulfide hydroxide." [RESID:AA0298] synonym: "copper incorporation into copper-sulphur cluster via heptakis-L-histidino tetracopper mu4-sulphide hydroxide" EXACT [] xref: RESID:AA0298 is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018428 ! copper incorporation into copper-sulfur cluster [Term] id: GO:0018439 name: peptidyl-L-leucine methyl ester biosynthetic process from peptidyl-leucine namespace: biological_process alt_id: GO:0018440 def: "The modification of a C-terminal peptidyl-leucine to form peptidyl-L-leucine methyl ester." [RESID:AA0299] synonym: "peptidyl-leucine esterification" EXACT [] xref: RESID:AA0299 is_a: GO:0006481 ! C-terminal protein methylation is_a: GO:0018203 ! peptidyl-isoleucine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018441 name: iron incorporation into iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide namespace: biological_process def: "The incorporation of iron into a 8Fe-7S iron-sulfur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulfide, found in nitrogenase." [PMID:9063865, RESID:AA0300] synonym: "iron incorporation into iron-sulphur cluster via hexakis-L-cysteinyl L-serinyl octairon heptasulphide" EXACT [] xref: RESID:AA0300 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster is_a: GO:0018418 ! nickel incorporation into iron-sulfur cluster via tris-L-cysteinyl L-cysteine persulfido L-glutamato L-histidino L-serinyl nickel triiron disulfide trioxide [Term] id: GO:0018442 name: peptidyl-glutamic acid esterification namespace: biological_process def: "The addition of an ester group to a glutamic acid residue in a protein." [GOC:mah] is_a: GO:0018200 ! peptidyl-glutamic acid modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0018443 name: enzyme active site formation via L-aspartic 4-phosphoric anhydride namespace: biological_process def: "The transient phosphorylation of peptidyl-aspartic acid to form L-aspartic 4-phosphoric anhydride." [RESID:AA0033] xref: RESID:AA0033 is_a: GO:0018217 ! peptidyl-aspartic acid phosphorylation is_a: GO:0018307 ! enzyme active site formation [Term] id: GO:0018444 name: translation release factor complex namespace: cellular_component def: "A heterodimeric complex involved in the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] synonym: "eukaryotic peptide chain release factor" EXACT [] synonym: "peptide chain release factor" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0018445 name: prothoracicotrophic hormone activity namespace: molecular_function def: "The action characteristic of prothoracicotrophic hormone, a peptide hormone that is secreted by the brain and, upon receptor binding, acts on the prothoracic gland to stimulate the release of ecdysone in insects." [GOC:mah, PMID:3301403] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0018446 name: pinocarveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = pinocarvone + 2 H+ + 2 e-." [UM-BBD_reactionID:r0717] xref: UM-BBD_reactionID:r0717 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018447 name: chloral hydrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reactions: chloral hydrate = 3 H+ + 2 e- + trichloroacetate, and chloral hydrate + H2 = H2O + trichloroethanol." [UM-BBD_enzymeID:e0229] xref: UM-BBD_enzymeID:e0229 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018448 name: hydroxymethylmethylsilanediol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylmethylsilanediol + O2 + 2 H+ + 2 e- = formylmethylsilanediol + 2 H2O." [UM-BBD_reactionID:r0638] xref: UM-BBD_reactionID:r0638 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018449 name: 1-phenylethanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-1-phenylethanol = acetophenone + H2." [UM-BBD_reactionID:r0032] xref: UM-BBD_reactionID:r0032 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018450 name: myrtenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenol + O2 + 2 H+ + 2 e- = 2 H2O + myrtenal." [UM-BBD_reactionID:r0710] xref: UM-BBD_reactionID:r0710 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018451 name: epoxide dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: ethene oxide + NAD+ + CoA-SH = NADH + H+ + acetyl-CoA." [UM-BBD_reactionID:r0595] xref: UM-BBD_reactionID:r0595 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018452 name: 5-exo-hydroxycamphor dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-exo-hydroxycamphor + NAD+ = NADH + H+ + 2,5-diketocamphane." [UM-BBD_reactionID:r0427] xref: EC:1.1.1.327 xref: MetaCyc:R542-RXN xref: UM-BBD_reactionID:r0427 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018453 name: 2-hydroxytetrahydrofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 2 H+ + 2 e- + butyrolactone." [UM-BBD_reactionID:r0018] xref: UM-BBD_reactionID:r0018 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018454 name: acetoacetyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxyacyl-CoA + NADP+ = 3-oxoacyl-CoA + NADPH + H+." [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "(R)-3-hydroxyacyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "acetoacetyl coenzyme A reductase activity" EXACT [EC:1.1.1.36] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.36] synonym: "D(-)-beta-hydroxybutyryl CoA-NADP oxidoreductase activity" EXACT [EC:1.1.1.36] synonym: "D-3-hydroxyacyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "hydroxyacyl coenzyme-A dehydrogenase activity" EXACT [EC:1.1.1.36] synonym: "NADP-linked acetoacetyl CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "NADPH:acetoacetyl-CoA reductase activity" EXACT [EC:1.1.1.36] synonym: "short chain beta-ketoacetyl(acetoacetyl)-CoA reductase activity" EXACT [EC:1.1.1.36] xref: EC:1.1.1.36 xref: MetaCyc:RXN-7698 xref: RHEA:22256 xref: UM-BBD_reactionID:r0202 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018455 name: alcohol dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD(P)+ = an aldehyde + NAD(P)H + H+." [EC:1.1.1.71] synonym: "alcohol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.71] synonym: "aldehyde reductase (NADPH/NADH)" EXACT [EC:1.1.1.71] xref: EC:1.1.1.71 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN xref: RHEA:10736 xref: UM-BBD_reactionID:r0172 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018456 name: aryl-alcohol dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic alcohol + NAD+ = an aromatic aldehyde + NADH + H+." [EC:1.1.1.90] synonym: "aryl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.90] synonym: "benzyl alcohol dehydrogenase activity" NARROW [] synonym: "p-hydroxybenzyl alcohol dehydrogenase activity" NARROW [EC:1.1.1.90] xref: EC:1.1.1.90 xref: MetaCyc:ARYL-ALCOHOL-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0019 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018457 name: perillyl-alcohol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + perillyl alcohol = H(+) + NADH + perillyl aldehyde." [EC:1.1.1.144, RHEA:10664] synonym: "perillyl alcohol dehydrogenase activity" EXACT [EC:1.1.1.144] synonym: "perillyl-alcohol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.144] xref: EC:1.1.1.144 xref: KEGG:R03945 xref: MetaCyc:PERILLYL-ALCOHOL-DEHYDROGENASE-RXN xref: RHEA:10664 xref: UM-BBD_reactionID:r0729 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018458 name: isopiperitenol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,6R)-isopiperitenol + NAD(+) = (6R)-isoperitenone + H(+) + NADH." [EC:1.1.1.223, RHEA:20860] synonym: "(-)-trans-isopiperitenol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.223] xref: EC:1.1.1.223 xref: KEGG:R03261 xref: MetaCyc:ISOPIPERITENOL-DEHYDROGENASE-RXN xref: RHEA:20860 xref: UM-BBD_reactionID:r0740 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018459 name: carveol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,5R)-carveol + NADP(+) = (R)-carvone + H(+) + NADPH." [EC:1.1.1.243, RHEA:13629] synonym: "(-)-trans-carveol dehydrogenase activity" EXACT [EC:1.1.1.243] synonym: "(-)-trans-carveol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.243] xref: EC:1.1.1.243 xref: KEGG:R03114 xref: MetaCyc:CARVEOL-DEHYDROGENASE-RXN xref: RHEA:13629 xref: UM-BBD_reactionID:r0714 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018460 name: cyclohexanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanol + NAD+ = cyclohexanone + NADH + H+." [EC:1.1.1.245] synonym: "cyclohexanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.245] xref: EC:1.1.1.245 xref: MetaCyc:CYCLOHEXANOL-DEHYDROGENASE-RXN xref: RHEA:10044 xref: UM-BBD_reactionID:r0165 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018461 name: fluoren-9-ol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: fluoren-9-ol + 2 NADP+ = fluoren-9-one + 2 NADPH + 2 H+." [EC:1.1.1.256] synonym: "9-fluorenol dehydrogenase activity" EXACT [] synonym: "fluoren-9-ol:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.256] xref: EC:1.1.1.256 xref: MetaCyc:9-FLUORENOL-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0408 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018462 name: 4-(hydroxymethyl)benzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(hydroxymethyl)benzenesulfonate + NAD(+) = 4-formylbenzenesulfonate + H(+) + NADH." [EC:1.1.1.257, RHEA:24412] synonym: "4-(hydroxymethyl)benzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.257] synonym: "4-(hydroxymethyl)benzenesulphonate dehydrogenase activity" EXACT [] synonym: "4-sulfobenzyl alcohol dehydrogenase activity" EXACT [] xref: EC:1.1.1.257 xref: KEGG:R05271 xref: MetaCyc:1.1.1.257-RXN xref: RHEA:24412 xref: UM-BBD_reactionID:r0291 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018463 name: 6-hydroxyhexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxyhexanoate + NAD(+) = 6-oxohexanoate + H(+) + NADH." [EC:1.1.1.258, RHEA:14225] synonym: "6-hydroxyhexanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.258] xref: EC:1.1.1.258 xref: KEGG:R05283 xref: MetaCyc:6-HYDROXYHEXANOATE-OXIDATION-RXN xref: RHEA:14225 xref: UM-BBD_reactionID:r0174 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018464 name: 3-hydroxypimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxypimelyl-CoA + NAD(+) = 3-oxopimelyl-CoA + H(+) + NADH." [EC:1.1.1.259, RHEA:11168] synonym: "3-hydroxypimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.259] xref: EC:1.1.1.259 xref: KEGG:R05305 xref: MetaCyc:1.1.1.259-RXN xref: RHEA:11168 xref: UM-BBD_reactionID:r0196 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0018465 name: vanillyl-alcohol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: O(2) + vanillyl alcohol = H(2)O(2) + vanillin." [EC:1.1.3.38, RHEA:10036] synonym: "4-hydroxy-2-methoxybenzyl alcohol oxidase activity" EXACT [EC:1.1.3.38] synonym: "vanillyl alcohol:oxygen oxidoreductase activity" EXACT [EC:1.1.3.38] xref: EC:1.1.3.38 xref: KEGG:R02877 xref: MetaCyc:1.1.3.38-RXN xref: RHEA:10036 xref: UM-BBD_reactionID:r0651 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0018466 name: limonene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,2S,4R)-limonene-1,2-diol + DCPIP+ = DCPIPH + H+ + (1S,4R)-1-hydroxy-2-oxolimonene." [UM-BBD_reactionID:r0735] xref: EC:1.1.99 xref: UM-BBD_reactionID:r0735 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018467 name: formaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: formaldehyde + H(2)O + NAD(+) = formate + 2 H(+) + NADH." [EC:1.2.1.46, RHEA:16425] synonym: "formaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.46] synonym: "glutathione-independent formaldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.46 xref: KEGG:R00604 xref: MetaCyc:FORMALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:16425 xref: UM-BBD_reactionID:r0240 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0018468 name: alcohol dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: a primary alcohol + acceptor = an aldehyde + reduced acceptor." [EC:1.1.99.8] synonym: "alcohol:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "alcohol:acceptor oxidoreductase activity" EXACT [EC:1.1.99.8] synonym: "MDH" RELATED [EC:1.1.99.8] synonym: "PQQ-dependent alcohol dehydrogenase activity" EXACT [] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.99.8] synonym: "quinohemoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein alcohol dehydrogenase activity" EXACT [EC:1.1.99.8] synonym: "quinoprotein ethanol dehydrogenase activity" EXACT [EC:1.1.99.8] xref: EC:1.1.99.8 xref: UM-BBD_enzymeID:e0004 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0018469 name: myrtenal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: myrtenal + H2O = 2 H+ + 2 e- + myrtenic acid." [UM-BBD_reactionID:r0711] xref: UM-BBD_reactionID:r0711 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018470 name: 4-hydroxybutaraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybutyraldehyde + H2O = 2 H+ + 2 e- + 4-hydroxybutanoate." [UM-BBD_reactionID:r0014] xref: UM-BBD_reactionID:r0014 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018471 name: 4-chlorobenzaldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzaldehyde + 2 H2O = 4-chlorobenzoate + 2 H+ + 2 e-." [UM-BBD_reactionID:r0447] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0447 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018472 name: 1-hydroxy-2-naphthaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthaldehyde + NAD+ + H2O = NADH + H+ + 1-hydroxy-2-naphthoate." [UM-BBD_reactionID:r0485] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0485 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018473 name: cis-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + cis-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0744] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0744 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018474 name: 2-carboxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-carboxybenzaldehyde + NAD+ + H2O = NADH + 2 H+ + phthalate." [UM-BBD_reactionID:r0490] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0490 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0018475 name: trans-2-methyl-5-isopropylhexa-2,5-dienal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-2-methyl-5-isopropylhexa-2,5-dienal + NAD+ + H2O = NADH + H+ + trans-2-methyl-5-isopropylhexa-2,5-dienoic acid." [UM-BBD_reactionID:r0745] xref: EC:1.2.1 xref: UM-BBD_reactionID:r0745 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018477 name: benzaldehyde dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NADP+ + H2O = benzoate + NADPH + H+." [EC:1.2.1.7] synonym: "benzaldehyde:NADP+ oxidoreductase" EXACT [EC:1.2.1.7] synonym: "NADP-linked benzaldehyde dehydrogenase" EXACT [EC:1.2.1.7] xref: EC:1.2.1.7 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NADP+-RXN xref: RHEA:21660 xref: UM-BBD_enzymeID:e0079 is_a: GO:0033721 ! aldehyde dehydrogenase (NADP+) activity [Term] id: GO:0018478 name: malonate-semialdehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxopropanoate + CoA + NADP+ = acetyl-CoA + CO2 + NADPH + H+." [EC:1.2.1.18] synonym: "3-oxopropanoate:NAD(P)+ oxidoreductase (decarboxylating, CoA-acetylating)" EXACT [EC:1.2.1.18] synonym: "malonic semialdehyde oxidative decarboxylase activity" EXACT [] xref: EC:1.2.1.18 xref: MetaCyc:1.2.1.18-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018479 name: benzaldehyde dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD+ + H2O = benzoate + NADH + H+." [EC:1.2.1.28] synonym: "benzaldehyde (NAD) dehydrogenase activity" EXACT [EC:1.2.1.28] synonym: "benzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.28] xref: EC:1.2.1.28 xref: MetaCyc:BENZALDEHYDE-DEHYDROGENASE-NAD+-RXN xref: RHEA:11840 xref: UM-BBD_reactionID:r0269 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0018480 name: 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate semialdehyde + H2O + NAD+ = 5-carboxymethyl-2-hydroxymuconate + NADH + H+." [EC:1.2.1.60] synonym: "5-carboxymethyl-2-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.60] synonym: "carboxymethylhydroxymuconic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.60] xref: EC:1.2.1.60 xref: MetaCyc:CHMS-DEHYDROGENASE-RXN xref: RHEA:15681 xref: UM-BBD_reactionID:r0365 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018481 name: 4-hydroxymuconic-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis,trans-4-hydroxymuconate semialdehyde + H(2)O + NAD(+) = 2 H(+) + maleylacetate + NADH." [EC:1.2.1.61, RHEA:22420] synonym: "4-hydroxymuconic-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.61] xref: EC:1.2.1.61 xref: KEGG:R05236 xref: MetaCyc:1.2.1.61-RXN xref: RHEA:22420 xref: UM-BBD_reactionID:r0229 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018482 name: 4-formylbenzenesulfonate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-formylbenzenesulfonate + H(2)O + NAD(+) = 4-sulfobenzoate + 2 H(+) + NADH." [EC:1.2.1.62, RHEA:18833] synonym: "4-formylbenzenesulfonate:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.62] synonym: "4-formylbenzenesulphonate dehydrogenase activity" EXACT [] synonym: "toluene-sulfonate aldehyde dehydrogenase activity" EXACT [] xref: EC:1.2.1.62 xref: KEGG:R05272 xref: MetaCyc:1.2.1.62-RXN xref: RHEA:18833 xref: UM-BBD_reactionID:r0292 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018483 name: 6-oxohexanoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxohexanoate + NADP+ + H2O = adipate + NADPH + H+." [EC:1.2.1.63] synonym: "6-oxohexanoate:NADP+ oxidoreductase activity" EXACT [EC:1.2.1.63] xref: EC:1.2.1.63 xref: MetaCyc:6-OXOHEXANOATE-OXIDATION-RXN xref: RHEA:13397 xref: UM-BBD_reactionID:r0175 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018484 name: 4-hydroxybenzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzaldehyde + NAD+ + H2O = 4-hydroxybenzoate + NADH + H+." [EC:1.2.1.64] synonym: "3-hydroxybenzaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.64] synonym: "p-hydroxybenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.64] xref: EC:1.2.1.64 xref: MetaCyc:HYDROXYBENZALDEHYDE-OXIDATION-NAD-RXN xref: RHEA:20305 xref: UM-BBD_reactionID:r0273 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0018485 name: salicylaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylaldehyde + NAD+ + H2O = salicylate + NADH + H+." [EC:1.2.1.65] synonym: "salicylaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.65] xref: EC:1.2.1.65 xref: MetaCyc:1.2.1.65-RXN xref: RHEA:18537 xref: UM-BBD_enzymeID:e0256 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0018486 name: 2-butanone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methyl ethyl ketone + O2 = H2O + ethyl acetate." [UM-BBD_reactionID:r0169] xref: UM-BBD_reactionID:r0169 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018487 name: vanillate O-demethylase (anaerobic) activity namespace: molecular_function def: "Catalysis of the reaction: vanillate + Co+ = Co3+-CH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0758] xref: UM-BBD_reactionID:r0758 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018488 name: aryl-aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + O2 + H2O = an aromatic acid + hydrogen peroxide." [EC:1.2.3.9] synonym: "aryl-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.9] xref: EC:1.2.3.9 xref: MetaCyc:ARYL-ALDEHYDE-OXIDASE-RXN xref: UM-BBD_reactionID:r0145 is_a: GO:0004031 ! aldehyde oxidase activity [Term] id: GO:0018489 name: vanillate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + vanillate = 3,4-dihydroxybenzoate + formaldehyde + H(2)O + NAD(+)." [EC:1.14.13.82, RHEA:13021] comment: Note that this was EC:1.2.3.12. synonym: "4-hydroxy-3-methoxybenzoate demethylase activity" EXACT [EC:1.14.13.82] synonym: "vanillate demethylase (aerobic) activity" EXACT [] synonym: "vanillate demethylase activity" EXACT [] synonym: "vanillate:oxygen oxidoreductase (demethylating)" EXACT [EC:1.14.13.82] xref: EC:1.14.13.82 xref: KEGG:R05274 xref: MetaCyc:RXN-10891 xref: MetaCyc:RXN-2 xref: RHEA:13021 xref: UM-BBD_reactionID:r0146 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0018490 name: 4-hydroxyphenylpyruvate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 (4-hydroxyphenyl)pyruvate + O(2) = 2 (4-hydroxyphenyl)acetate + 2 CO(2)." [EC:1.2.3.13, RHEA:17197] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (decarboxylating)" BROAD [EC:1.2.3.13] xref: EC:1.2.3.13 xref: KEGG:R00042 xref: MetaCyc:1.2.3.13-RXN xref: RHEA:17197 xref: UM-BBD_reactionID:r0299 is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0018491 name: 2-oxobutyrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxobutanoate + CoA + oxidized ferredoxin = propanoyl-CoA + CO2 + reduced ferredoxin." [EC:1.2.7.2] synonym: "2-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "2-oxobutanoate:ferredoxin 2-oxidoreductase (CoA-propionylating)" EXACT [EC:1.2.7.2] synonym: "2-oxobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate synthase activity" EXACT [EC:1.2.7.2] synonym: "alpha-ketobutyrate-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.2] xref: EC:1.2.7.2 xref: MetaCyc:2-OXOBUTYRATE-SYNTHASE-RXN xref: UM-BBD_reactionID:r0358 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0018492 name: carbon-monoxide dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: CO + H2O + acceptor = CO2 + reduced acceptor." [EC:1.2.99.2] synonym: "anaerobic carbon monoxide dehydrogenase activity" EXACT [EC:1.2.99.2] synonym: "carbon monoxide dehydrogenase activity" BROAD [] synonym: "carbon-monoxide:acceptor oxidoreductase activity" EXACT [EC:1.2.99.2] xref: EC:1.2.99.2 xref: MetaCyc:CARBON-MONOXIDE-DEHYDROGENASE-RXN xref: RHEA:17829 xref: UM-BBD_enzymeID:e0415 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018493 name: formylmethanofuran dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N-formylmethanofuran + A + H(2)O + H(+) = AH(2) + CO(2) + methanofuran." [EC:1.2.99.5, RHEA:19841] synonym: "formylmethanofuran:(acceptor) oxidoreductase activity" EXACT [EC:1.2.99.5] synonym: "formylmethanofuran:acceptor oxidoreductase activity" EXACT [EC:1.2.99.5] xref: EC:1.2.99.5 xref: KEGG:R03015 xref: MetaCyc:FORMYLMETHANOFURAN-DEHYDROGENASE-RXN xref: RHEA:19841 xref: UM-BBD_reactionID:r0345 is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0018494 name: carvone reductase activity namespace: molecular_function def: "Catalysis of the reaction: carvone + 2 H+ + 2 e- = dihydrocarvone." [UM-BBD_reactionID:r0732] xref: EC:1.3.99.25 xref: MetaCyc:RXN-9403 xref: MetaCyc:RXN-9419 xref: UM-BBD_reactionID:r0732 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018495 name: 2-hydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 2-ketocyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0192] xref: UM-BBD_reactionID:r0192 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018496 name: 2,6-dihydroxycyclohexane-1-carboxyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxycyclohexane-1-carboxyl-CoA = 2 H+ + 2 e- + 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0205] xref: UM-BBD_reactionID:r0205 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018497 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethene + 2 H+ + 2 e- = 1-chloro-2,2-bis(4-chlorophenyl)ethane. 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU; 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS." [UM-BBD_reactionID:r0514] synonym: "DDMS dehydrogenase activity" EXACT [] xref: UM-BBD_reactionID:r0514 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018498 name: 2,3-dihydroxy-2,3-dihydro-phenylpropionate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol + NAD+ = NADH + H+ + 3-(2,3-dihydroxyphenyl)propionate." [UM-BBD_enzymeID:e0308] xref: MetaCyc:PHENPRODIOLDEHYDROG-RXN xref: UM-BBD_enzymeID:e0308 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018499 name: cis-2,3-dihydrodiol DDT dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydrodiol DDT + NADP+ = NADPH + 2,3-dihydroxy DDT." [UM-BBD_reactionID:r0451] xref: UM-BBD_reactionID:r0451 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018500 name: trans-9R,10R-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + NAD+ = NADH + H+ + 9,10-dihydroxyphenanthrene." [UM-BBD_reactionID:r0575] xref: UM-BBD_reactionID:r0575 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018501 name: cis-chlorobenzene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the conversion of a di- or tetrachlorinated dienol to the corresponding catechol." [UM-BBD_enzymeID:e0411] xref: UM-BBD_enzymeID:e0411 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018502 name: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dichloro-2,5-cyclohexadiene-1,4-diol + NAD+ = NADH + H+ + 2,5-dichlorohydroquinone." [UM-BBD_reactionID:r0553] xref: MetaCyc:LINC-RXN xref: UM-BBD_reactionID:r0553 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018503 name: trans-1,2-dihydrodiolphenanthrene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-1,2-dihydrodiolphenanthrene + NAD+ = H+ + NADH + 1,2-dihydroxyphenanthrene." [UM-BBD_reactionID:r0574] xref: UM-BBD_reactionID:r0574 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018504 name: cis-1,2-dihydrobenzene-1,2-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydrobenzene-1,2-diol + NAD+ = catechol + NADH + H+." [EC:1.3.1.19] synonym: "cis-1,2-dihydrobenzene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-1,2-dihydrocyclohexa-3,5-diene (nicotinamide adenine dinucleotide) oxidoreductase activity" EXACT [EC:1.3.1.19] synonym: "cis-benzene glycol dehydrogenase activity" EXACT [EC:1.3.1.19] xref: EC:1.3.1.19 xref: MetaCyc:1.3.1.19-RXN xref: UM-BBD_enzymeID:e0060 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018505 name: cis-1,2-dihydro-1,2-dihydroxynaphthalene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydronaphthalene-1,2-diol + NAD+ = naphthalene-1,2-diol + NADH + H+." [EC:1.3.1.29] synonym: "(+)-cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "1,2-dihydroxy-1,2-dihydroxynaphthalene dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydronaphthalene-1,2-diol:NAD+ 1,2-oxidoreductase activity" EXACT [EC:1.3.1.29] synonym: "cis-dihydrodiol naphthalene dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "cis-naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] synonym: "naphthalene dihydrodiol dehydrogenase activity" EXACT [EC:1.3.1.29] xref: EC:1.3.1.29 xref: MetaCyc:1.3.1.29-RXN xref: RHEA:11832 xref: UM-BBD_enzymeID:e0122 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018506 name: maleylacetate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxoadipate + NAD(P)+ = 2-maleylacetate + NAD(P)H + H+." [EC:1.3.1.32] synonym: "3-oxoadipate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.32] synonym: "maleolylacetate reductase activity" EXACT [EC:1.3.1.32] xref: EC:1.3.1.32 xref: MetaCyc:MALEYLACETATE-REDUCTASE-RXN xref: UM-BBD_enzymeID:e0063 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018507 name: cis-3,4-dihydrophenanthrene-3,4-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (3S,4R)-3,4-dihydrophenanthrene-3,4-diol + NAD(+) = H(+) + NADH + phenanthrene-3,4-diol." [EC:1.3.1.49, RHEA:16253] synonym: "(+)-cis-3,4-dihydrophenanthrene-3,4-diol:NAD+ 3,4-oxidoreductase activity" EXACT [EC:1.3.1.49] synonym: "cis-3,4-dihydroxy-3,4-dihydrophenanthrene dehydrogenase activity" EXACT [] xref: EC:1.3.1.49 xref: KEGG:R04151 xref: MetaCyc:1.3.1.49-RXN xref: RHEA:16253 xref: UM-BBD_reactionID:r0488 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018508 name: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxycyclohexa-3,5-diene-1-carboxylate + NAD+ = catechol + CO2 + NADH + H+." [MetaCyc:BENZOATE-CIS-DIOL-DEHYDROGENASE-RXN] synonym: "benzoate cis-diol dehydrogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0219 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018509 name: cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+ = biphenyl-2,3-diol + NADH + H+." [EC:1.3.1.56] synonym: "2,3-dihydro-2,3-dihydroxybiphenyl dehydrogenase activity" EXACT [] synonym: "biphenyl-2,3-dihydro-2,3-diol dehydrogenase activity" EXACT [EC:1.3.1.56] synonym: "cis-3-phenylcyclohexa-3,5-diene-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.56] xref: EC:1.3.1.56 xref: MetaCyc:1.3.1.56-RXN xref: RHEA:17033 xref: UM-BBD_enzymeID:e0134 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018510 name: phloroglucinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + NADP(+) = H(+) + NADPH + phloroglucinol." [EC:1.3.1.57, RHEA:10080] synonym: "dihydrophloroglucinol:NADP+ oxidoreductase activity" EXACT [EC:1.3.1.57] xref: EC:1.3.1.57 xref: KEGG:R05308 xref: MetaCyc:R5-RXN xref: RHEA:10080 xref: UM-BBD_reactionID:r0007 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018511 name: 2,3-dihydroxy-2,3-dihydro-p-cumate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2,3-dihydroxy-2,3-dihydro-p-cumate + NAD(+) = 2,3-dihydroxy-p-cumate + H(+) + NADH." [EC:1.3.1.58, RHEA:23772] synonym: "cis-2,3-dihydroxy-2,3-dihydro-p-cumate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.58] xref: EC:1.3.1.58 xref: KEGG:R05240 xref: MetaCyc:RXN-665 xref: RHEA:23772 xref: UM-BBD_reactionID:r0396 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018512 name: obsolete 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate + NAD+ = 3-methylcatechol + CO2 + NADH + H+." [EC:1.3.1.59] comment: This term was made obsolete because, according to the Enzyme Commission, there is no evidence that this enzymatic activity exists. synonym: "1,2-dihydroxy-3-methylcyclohexa-3,5-diene-carboxylate dehydrogenase activity" EXACT [] synonym: "1,6-dihydroxy-5-methylcyclohexa-2,4-dienecarboxylate dehydrogenase activity" EXACT [] xref: EC:1.3.1.59 xref: UM-BBD_reactionID:r0216 is_obsolete: true [Term] id: GO:0018513 name: dibenzothiophene dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene + NAD(+) = 1,2-dihydroxydibenzothiophene + H(+) + NADH." [EC:1.3.1.60, RHEA:24188] synonym: "cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.60] xref: EC:1.3.1.60 xref: KEGG:R05310 xref: MetaCyc:1.3.1.60-RXN xref: RHEA:24188 xref: UM-BBD_reactionID:r0161 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018515 name: pimeloyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(+) + pimelyl-CoA = 2,3-didehydropimeloyl-CoA + H(+) + NADH." [EC:1.3.1.62, RHEA:19665] synonym: "pimeloyl-CoA:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.62] xref: EC:1.3.1.62 xref: KEGG:R05311 xref: MetaCyc:1.3.1.62-RXN xref: RHEA:19665 xref: UM-BBD_reactionID:r0194 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018516 name: 2,4-dichlorobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + chloride + NADP(+) = 2,4-dichlorobenzoyl-CoA + NADPH." [EC:1.3.1.63, RHEA:23076] synonym: "4-chlorobenzoyl-CoA:NADP+ oxidoreductase (halogenating)" EXACT [EC:1.3.1.63] xref: EC:1.3.1.63 xref: KEGG:R05276 xref: MetaCyc:1.3.1.63-RXN xref: RHEA:23076 xref: UM-BBD_reactionID:r0138 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018517 name: phthalate 4,5-cis-dihydrodiol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+) = 4,5-dihydroxyphthalate + H(+) + NADH." [EC:1.3.1.64, RHEA:13837] synonym: "cis-4,5-dihydroxycyclohexa-1(6),2-diene-1,2-dicarboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.64] xref: EC:1.3.1.64 xref: KEGG:R05275 xref: MetaCyc:1.3.1.64-RXN xref: RHEA:13837 xref: UM-BBD_reactionID:r0142 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018518 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-5,6-dihydroquinolin-2(1H)-one + NAD(+) = 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + H(+) + NADH." [EC:1.3.1.65, RHEA:24556] synonym: "5,6-dihydrodiol-3-methyl-2-oxo-1,2-dihydroquinoline dehydrogenase" RELATED [] synonym: "5,6-dihydroxy-3-methyl-2-oxo-1,2,5,6-tetrahydroquinoline:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.65] xref: EC:1.3.1.65 xref: KEGG:R05312 xref: MetaCyc:RXN-643 xref: RHEA:24556 xref: UM-BBD_reactionID:r0053 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018519 name: cis-dihydroethylcatechol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydro-3-ethylcatechol + NAD(+) = 3-ethylcatechol + H(+) + NADH." [EC:1.3.1.66, RHEA:18101] synonym: "cis-1,2-dihydro-3-ethylcatechol:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.66] synonym: "cis-ethylbenzene glycol dehydrogenase activity" EXACT [] xref: EC:1.3.1.66 xref: KEGG:R05313 xref: MetaCyc:1.3.1.66-RXN xref: RHEA:18101 xref: UM-BBD_reactionID:r0309 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018520 name: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate + NADP+ = 4-methylcatechol + NADPH + H+ + CO2." [EC:1.3.1.67] synonym: "4-methylcyclohexa-3,5-diene-1,2-cis-diol-1-carboxylic acid dehydrogenase activity" EXACT [] synonym: "cis-1,2-dihydroxy-4-methylcyclohexa-3,5-diene-1-carboxylate:NAD(P)+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.67] xref: EC:1.3.1.67 xref: MetaCyc:1.3.1.67-RXN xref: UM-BBD_reactionID:r0179 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018521 name: 1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,6-dihydroxy-2-methylcyclohexa-2,4-dienecarboxylate + NAD(+) = 3-methylcatechol + CO(2) + NADH." [EC:1.3.1.68, RHEA:15657] synonym: "1,2-dihydroxy-6-methylcyclohexa-3,5-dienecarboxylate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.68] xref: EC:1.3.1.68 xref: KEGG:R05314 xref: MetaCyc:1.3.1.68-RXN xref: RHEA:15657 xref: UM-BBD_reactionID:r0224 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0018522 name: benzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ADP + cyclohexa-1,5-diene-1-carbonyl-CoA + oxidized ferredoxin + 2 phosphate = 2 ATP + 2 H(2)O + benzoyl-CoA + reduced ferredoxin." [EC:1.3.7.8] synonym: "benzoyl-CoA reductase (dearomatizing) activity" EXACT [EC:1.3.7.8] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA:ferredoxin oxidoreductase (aromatizing, ATP-forming) activity" EXACT [KEGG:R02451] xref: EC:1.3.7.8 xref: KEGG:R02451 xref: MetaCyc:1.3.99.15-RXN xref: UM-BBD_reactionID:r0190 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0018523 name: quinoline 2-oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: quinoline + acceptor + H2O = isoquinolin-1(2H)-one + reduced acceptor." [EC:1.3.99.17] synonym: "quinoline:acceptor 2-oxidoreductase (hydroxylating)" EXACT [EC:1.3.99.17] xref: EC:1.3.99.17 xref: MetaCyc:1.3.99.17-RXN xref: UM-BBD_reactionID:r0045 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0018524 name: acetophenone carboxylase activity namespace: molecular_function alt_id: GO:0018797 def: "Catalysis of the reaction: acetophenone + CO2 = H+ + benzoyl acetate." [UM-BBD_reactionID:r0033] xref: EC:6.4.1 xref: UM-BBD_reactionID:r0033 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018525 name: 4-hydroxybenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl-CoA + oxidized ferredoxin + H2O = 4-hydroxybenzoyl-CoA + reduced ferredoxin." [KEGG:R05316] synonym: "4-hydroxybenzoyl-coA reductase (dehydroxylating) activity" EXACT [EC:1.3.7.9] synonym: "4-hydroxybenzoyl-coA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.7.9] xref: EC:1.3.7.9 xref: KEGG:R05316 xref: MetaCyc:OHBENZCOARED-RXN xref: UM-BBD_reactionID:r0158 is_a: GO:0016636 ! oxidoreductase activity, acting on the CH-CH group of donors, iron-sulfur protein as acceptor [Term] id: GO:0018526 name: 2-aminobenzoyl-CoA reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 H+ + 2 e- = NH3 + benzoyl-CoA." [UM-BBD_reactionID:r0342] xref: UM-BBD_reactionID:r0342 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0018527 name: cyclohexylamine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylamine + O2 + H2O = cyclohexanone + NH3 + hydrogen peroxide." [EC:1.4.3.12] synonym: "cyclohexylamine:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.12] xref: EC:1.4.3.12 xref: MetaCyc:CYCLOHEXYLAMINE-OXIDASE-RXN xref: RHEA:18433 xref: UM-BBD_reactionID:r0754 is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0018528 name: iminodiacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: iminodiacetate + OH- = H+ + 2 e- + glyoxylate + glycine." [UM-BBD_reactionID:r0589] xref: UM-BBD_reactionID:r0589 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018529 name: nitrilotriacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + NADH + H+ + O2 = NAD+ + H2O + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0587] xref: EC:1.14.14.10 xref: UM-BBD_reactionID:r0587 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0018530 name: (R)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.6, RHEA:10012] synonym: "(R)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.6] synonym: "6-hydroxy-D-nicotine oxidase activity" EXACT [] synonym: "D-6-hydroxynicotine oxidase activity" EXACT [EC:1.5.3.6] xref: EC:1.5.3.6 xref: KEGG:R07170 xref: MetaCyc:R-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:10012 xref: UM-BBD_reactionID:r0477 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018531 name: (S)-6-hydroxynicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-6-hydroxynicotine + H(2)O + O(2) = 6-hydroxypseudooxynicotine + H(2)O(2)." [EC:1.5.3.5, RHEA:11880] synonym: "(S)-6-hydroxynicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "6-hydroxy-L-nicotine oxidase activity" EXACT [] synonym: "6-hydroxy-L-nicotine:oxygen oxidoreductase activity" EXACT [EC:1.5.3.5] synonym: "L-6-hydroxynicotine oxidase activity" EXACT [] xref: EC:1.5.3.5 xref: KEGG:R03202 xref: MetaCyc:S-6-HYDROXYNICOTINE-OXIDASE-RXN xref: RHEA:11880 xref: UM-BBD_reactionID:r0478 is_a: GO:0019116 ! hydroxy-nicotine oxidase activity [Term] id: GO:0018532 name: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: N5,N10-methenyltetrahydromethanopterin + H2 = N5,N10-methylenetetrahydromethanopterin." [UM-BBD_reactionID:r0353] synonym: "coenzyme F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "coenzyme F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] synonym: "F420-independent 5,10-methenyl-5,6,7,8-tetrahydromethanopterin dehydrogenase activity" EXACT [] synonym: "F420-independent methylene-H4MPT dehydrogenase activity" EXACT [] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0353 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018533 name: peptidyl-cysteine acetylation namespace: biological_process def: "The acetylation of peptidyl-cysteine." [GOC:mah] is_a: GO:0006473 ! protein acetylation is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0018534 name: nitrilotriacetate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrilotriacetate + OH- = H+ + 2 e- + glyoxylate + iminodiacetate." [UM-BBD_reactionID:r0588] xref: EC:1.5.99 xref: UM-BBD_reactionID:r0588 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018535 name: nicotine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: nicotine + acceptor + H2O = (S)-6-hydroxynicotine + reduced acceptor." [EC:1.5.99.4] synonym: "D-nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine oxidase activity" EXACT [EC:1.5.99.4] synonym: "nicotine:(acceptor) 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] synonym: "nicotine:acceptor 6-oxidoreductase (hydroxylating)" EXACT [EC:1.5.99.4] xref: EC:1.5.99.4 xref: MetaCyc:NICOTINE-DEHYDROGENASE-RXN xref: RHEA:14769 xref: UM-BBD_enzymeID:e0337 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018537 name: coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme F420 + H(+) = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.11, RHEA:21144] synonym: "5,10-methylenetetrahydromethanopterin cyclohydrolase activity" EXACT [EC:1.5.99.11] synonym: "5,10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "5-methyltetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "coenzyme F420-dependent N(5),N(10)-methenyltetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H(4)MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylene-H4MPT reductase activity" EXACT [EC:1.5.99.11] synonym: "methylenetetrahydromethanopterin reductase activity" EXACT [] synonym: "N(5),N(10)-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N(5),N(10)-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin reductase activity" EXACT [EC:1.5.99.11] synonym: "N5,N10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.11] xref: EC:1.5.99.11 xref: KEGG:R04464 xref: MetaCyc:METHELENE-THMPT-OXI-RXN xref: RHEA:21144 xref: UM-BBD_reactionID:r0354 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0018538 name: epoxide carboxylase activity namespace: molecular_function def: "Catalysis of the generic reaction: epoxide + CO2 + NAD+ + electron donor = beta-keto acid + NADH + reduced electron donor; the electron donor may be NADPH or a dithiol. This reaction is the ring opening and carboxylation of an epoxide; for example: epoxypropane + CO2 + NAD+ + NADPH = acetoacetate + NADH + NADP+." [PMID:9555888] is_a: GO:0016651 ! oxidoreductase activity, acting on NAD(P)H [Term] id: GO:0018541 name: p-benzoquinone reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-benzoquinone + H(+) + NADPH = hydroquinone + NADP(+)." [EC:1.6.5.6, RHEA:23488] synonym: "NADPH:p-benzoquinone oxidoreductase activity" EXACT [EC:1.6.5.6] xref: EC:1.6.5.6 xref: KEGG:R05244 xref: MetaCyc:1.6.5.6-RXN xref: RHEA:23488 xref: UM-BBD_enzymeID:e0422 is_a: GO:0016655 ! oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor [Term] id: GO:0018542 name: 2,3-dihydroxy DDT 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy DDT + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8,8-tetrachloroocta-2E,4E-dienoate." [UM-BBD_reactionID:r0452] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0452 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018543 name: 4-amino-2-nitroso-6-nitrotoluene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-2-hydroxylamino-6-nitrotoluene + NADP+ = NADPH + H+ + 4-amino-2-nitroso-6-nitrotoluene." [UM-BBD_reactionID:r0464] xref: UM-BBD_reactionID:r0464 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018544 name: 4-carboxy-4'-sulfoazobenzene reductase activity namespace: molecular_function def: "Catalysis of the reaction: 4-carboxy-4'-sulfoazobenzene + 4 H+ + 4 e- = 4-aminobenzoate + 4-aminobenzenesulfonate." [UM-BBD_reactionID:r0543] synonym: "4-carboxy-4'-sulphoazobenzene reductase activity" EXACT [] xref: UM-BBD_reactionID:r0543 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018545 name: NAD(P)H nitroreductase activity namespace: molecular_function def: "Catalysis of the conversion of a nitrate group to an amino or hydroxylamino group on toluene or a toluene derivative." [UM-BBD_enzymeID:e0346] xref: UM-BBD_enzymeID:e0346 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018546 name: nitrobenzene nitroreductase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + 2 NADPH + 2 H+ = hydroxyaminobenzene + 2 NADP+ + H2O." [MetaCyc:RXN-8815] xref: MetaCyc:RXN-8815 xref: UM-BBD_enzymeID:e0245 is_a: GO:0016657 ! oxidoreductase activity, acting on NAD(P)H, nitrogenous group as acceptor [Term] id: GO:0018547 name: nitroglycerin reductase activity namespace: molecular_function def: "Catalysis of the removal of one or more nitrite (NO2-) groups from nitroglycerin or a derivative." [UM-BBD_enzymeID:e0038] synonym: "NG reductase activity" EXACT [] xref: EC:1.7.3 xref: UM-BBD_enzymeID:e0038 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0018548 name: pentaerythritol trinitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: pentaerythritol trinitrate + NADPH = NADP+ + nitrate + pentaerythritol dinitrate." [UM-BBD_reactionID:r0025] synonym: "xenobiotic reductase activity" BROAD [UM-BBD_enzymeID:e0028] xref: EC:1.6.99.1 xref: UM-BBD_reactionID:r0025 is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0018549 name: methanethiol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: methanethiol + O2 + H2O = formaldehyde + hydrogen sulfide + hydrogen peroxide." [EC:1.8.3.4] synonym: "(MM)-oxidase activity" EXACT [EC:1.8.3.4] synonym: "methanethiol:oxygen oxidoreductase activity" EXACT [EC:1.8.3.4] synonym: "methyl mercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "methylmercaptan oxidase activity" EXACT [EC:1.8.3.4] synonym: "MT-oxidase activity" EXACT [EC:1.8.3.4] xref: EC:1.8.3.4 xref: MetaCyc:METHANETHIOL-OXIDASE-RXN xref: RHEA:11812 xref: UM-BBD_reactionID:r0209 is_a: GO:0016670 ! oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor [Term] id: GO:0018550 name: tetrachloro-p-hydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5,6-tetrachlorohydroquinone + 2 glutathione = 2,3,6-trichlorohydroquinone + glutathione disulfide + HCl." [UM-BBD_reactionID:r0314] synonym: "tetrachlorohydroquinone reductive dehalogenase activity" EXACT [] xref: EC:1.8.99 xref: UM-BBD_reactionID:r0314 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018551 name: hydrogensulfite reductase activity namespace: molecular_function def: "Catalysis of the reaction: trithionate + acceptor + 2 H2O + OH- = 3 HSO3- + reduced acceptor." [EC:1.8.99.3] synonym: "bisulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "desulfofuscidin activity" NARROW [EC:1.8.99.3] synonym: "desulforubidin activity" NARROW [EC:1.8.99.3] synonym: "desulfoviridin activity" NARROW [EC:1.8.99.3] synonym: "dissimilatory sulfite reductase activity" EXACT [] synonym: "dissimilatory-type sulfite reductase activity" EXACT [EC:1.8.99.3] synonym: "hydrogensulphite reductase activity" EXACT [] synonym: "trithionate:(acceptor) oxidoreductase activity" EXACT [EC:1.8.99.3] synonym: "trithionate:acceptor oxidoreductase activity" EXACT [EC:1.8.99.3] xref: EC:1.8.99.3 xref: MetaCyc:HYDROGENSULFITE-REDUCTASE-RXN xref: RHEA:13209 xref: UM-BBD_reactionID:r0627 is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0018553 name: 3-(2,3-dihydroxyphenyl)propionate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-(2,3-dihydroxyphenyl)propionate + O2 = 2-hydroxy-6-keto-nona-2,4-dienedioate." [UM-BBD_enzymeID:e0309] xref: EC:1.13 xref: UM-BBD_enzymeID:e0309 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018554 name: 1,2-dihydroxynaphthalene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene + O2 = 2-hydroxychromene-2-carboxylate. C6 of the substrate molecular may have an NH2 group attached." [UM-BBD_enzymeID:e0255] xref: EC:1.13.11.56 xref: RHEA:27310 xref: UM-BBD_enzymeID:e0255 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018555 name: phenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + NADH + H+ + O2 = NAD+ + cis-3,4-dihydroxy-3,4-dihydrophenanthrene." [UM-BBD_reactionID:r0455] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0455 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018556 name: 2,2',3-trihydroxybiphenyl dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxybenzenoid + O2 = H+ + distal extradiol ring cleavage. Substrates are 2,2',3-trihydroxybiphenyl (forms 2-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate) and 2,2',3-trihydroxydiphenylether (forms 2,3-hydroxy-6-oxo-6-(2-hydroxyphenyl)-hexa-2,4-dienoate)." [UM-BBD_enzymeID:e0032] xref: EC:1.13.11 xref: UM-BBD_enzymeID:e0032 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018557 name: 1,2-dihydroxyfluorene 1,1-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyfluorene + O2 = 2-hydroxy-4-(2-oxo-1,3-dihydro-2H-inden-1-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0422] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0422 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018558 name: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 = 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon." [UM-BBD_reactionID:r0049] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0049 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018559 name: 1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2-(dihydroxy-4'-chorophenyl)-2-(4-chlorophenyl)ethene + O2 = 6-oxo-2-hydroxy-7-(4-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate." [UM-BBD_reactionID:r0442] synonym: "1,1-dichloro-2-(dihydroxy-4-chlorophenyl)-(4-chlorophenyl)ethylene 1,2-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0442 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018560 name: protocatechuate 3,4-dioxygenase type II activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfocatechol + O2 = 3-sulfomuconate." [UM-BBD_reactionID:r0581] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0581 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018561 name: 2'-aminobiphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-aminobiphenyl-2,3-diol + O2 = H+ + 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate." [UM-BBD_reactionID:r0457] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0457 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018562 name: 3,4-dihydroxyfluorene 4,4-alpha-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyfluorene + O2 = 2-hydroxy-4-(1-oxo-1,3-dihydro-2H-inden-2-ylidene) but-2-enoic acid." [UM-BBD_reactionID:r0415] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0415 is_a: GO:0019117 ! dihydroxyfluorene dioxygenase activity [Term] id: GO:0018563 name: 2,3-dihydroxy-ethylbenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxyethylbenzene + O2 = H+ + 2-hydroxy-6-oxoocta-2,4-dienoate." [UM-BBD_reactionID:r0310] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0310 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018564 name: carbazole 1,9a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbazole + NADH + O2 + H+ = NAD+ + 2'-aminobiphenyl-2,3-diol." [UM-BBD_reactionID:r0456] synonym: "carbazole 1,9alpha-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0456 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018565 name: dihydroxydibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxydibenzothiophene + O2 = cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0162] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0162 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018566 name: 1,2-dihydroxynaphthalene-6-sulfonate 1,8a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxynaphthalene-6-sulfonate + O2 = H+ + (Z)-4-(2-hydroxy-5-sulfonatophenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0324] synonym: "1,2-dihydroxynaphthalene-6-sulphonate 1,8a-dioxygenase activity" EXACT [] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0324 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018567 name: styrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + O2 + NADH + H+ = NAD+ + styrene cis-glycol." [UM-BBD_reactionID:r0256] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0256 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018568 name: 3,4-dihydroxyphenanthrene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenanthrene + O2 = H+ + 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate." [UM-BBD_reactionID:r0501] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0501 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018569 name: hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: hydroquinone + O2 = cis,trans-4-hydroxymuconic semialdehyde." [UM-BBD_reactionID:r0228] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0228 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018570 name: p-cumate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-cumate + NADH + H+ + O2 = NAD+ + cis-2,3-dihydroxy-2,3-dihydro-p-cumate." [UM-BBD_reactionID:r0395] xref: EC:1.13.11 xref: MetaCyc:RXN-664 xref: UM-BBD_reactionID:r0395 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018571 name: 2,3-dihydroxy-p-cumate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-p-cumate + O2 = 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate." [MetaCyc:RXN-666, UM-BBD_reactionID:r0397] synonym: "2,3-dihydroxy-p-cumate 3,4-dioxygenase" EXACT [] synonym: "2,3-dihydroxy-p-cumate-3,4-dioxygenase" EXACT [] xref: EC:1.13.11 xref: MetaCyc:RXN-666 xref: UM-BBD_reactionID:r0397 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018572 name: 3,5-dichlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorocatechol + O2 = 2 H+ + 2,4-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0276] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0276 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018573 name: 2-aminophenol 1,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminophenol + O2 = 2-aminomuconic semialdehyde." [UM-BBD_reactionID:r0305] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0305 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018574 name: 2,6-dichloro-p-hydroquinone 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dichlorohydroquinone + O2 + H2O = HCl + 2 H+ + 2-chloromaleylacetate." [UM-BBD_enzymeID:e0422] xref: EC:1.13.11 xref: UM-BBD_enzymeID:e0422 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018575 name: chlorocatechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,6-dichlorocatechol + O2 = 2 H+ + 2,5-dichloro-cis,cis-muconate." [UM-BBD_reactionID:r0655] xref: EC:1.13.11 xref: UM-BBD_reactionID:r0655 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018576 name: catechol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = cis,cis-muconate." [EC:1.13.11.1] synonym: "1,2-pyrocatechase activity" EXACT [EC:1.13.11.1] synonym: "catechase activity" RELATED [EC:1.13.11.1] synonym: "catechol 1,2-oxygenase activity" EXACT [EC:1.13.11.1] synonym: "catechol-oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "catechol:oxygen 1,2-oxidoreductase activity" EXACT [EC:1.13.11.1] synonym: "CD I" RELATED [EC:1.13.11.1] synonym: "CD II" RELATED [EC:1.13.11.1] synonym: "pyrocatechase activity" RELATED [EC:1.13.11.1] synonym: "pyrocatechol 1,2-dioxygenase activity" EXACT [EC:1.13.11.1] xref: EC:1.13.11.1 xref: MetaCyc:CATECHOL-12-DIOXYGENASE-RXN xref: RHEA:23852 xref: UM-BBD_enzymeID:e0064 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018577 name: catechol 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = 2-hydroxymuconate semialdehyde." [EC:1.13.11.2] synonym: "2,3-pyrocatechase activity" EXACT [EC:1.13.11.2] synonym: "catechol 2,3-oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol oxygenase" EXACT [EC:1.13.11.2] synonym: "catechol:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.2] synonym: "cato2ase activity" RELATED [EC:1.13.11.2] synonym: "metapyrocatechase activity" RELATED [EC:1.13.11.2] synonym: "pyrocatechol 2,3-dioxygenase" EXACT [EC:1.13.11.2] xref: EC:1.13.11.2 xref: MetaCyc:CATECHOL-23-DIOXYGENASE-RXN xref: RHEA:17337 xref: UM-BBD_enzymeID:e0156 is_a: GO:0019114 ! catechol dioxygenase activity [Term] id: GO:0018578 name: protocatechuate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxybenzoate + O2 = 3-carboxy-cis,cis-muconate." [EC:1.13.11.3] synonym: "protocatechuate oxygenase activity" BROAD [EC:1.13.11.3] synonym: "protocatechuate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-dioxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic 3,4-oxygenase activity" EXACT [EC:1.13.11.3] synonym: "protocatechuic acid oxidase activity" EXACT [EC:1.13.11.3] xref: EC:1.13.11.3 xref: MetaCyc:PROTOCATECHUATE-34-DIOXYGENASE-RXN xref: RHEA:10084 xref: UM-BBD_reactionID:r0143 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018579 name: protocatechuate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protocatechuate + O2 = 4-carboxy-2-hydroxymuconate semialdehyde." [EC:1.13.11.8] synonym: "protocatechuate 4,5-oxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuate:oxygen 4,5-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-dioxygenase activity" EXACT [EC:1.13.11.8] synonym: "protocatechuic 4,5-oxygenase activity" EXACT [EC:1.13.11.8] xref: EC:1.13.11.8 xref: MetaCyc:PROTOCATECHUATE-45-DIOXYGENASE-RXN xref: RHEA:24044 xref: UM-BBD_reactionID:r0144 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018580 name: nitronate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylnitronate + O(2) = acetaldehyde + nitrite." [EC:1.13.12.16, RHEA:28770] comment: Where non-covalently bound FMN is used as the cofactor, see instead 'nitronate monooxygenase (FMN-linked) activity ; GO:0036434'. synonym: "2-nitropropane dioxygenase activity" RELATED [EC:1.13.11.32] synonym: "nitronate:oxygen 2-oxidoreductase (nitrite-forming) activity" EXACT systematic_synonym [EC:1.13.12.16] xref: EC:1.13.12.16 xref: MetaCyc:2-NITROPROPANE-DIOXYGENASE-RXN xref: RHEA:28770 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0018581 name: hydroxyquinol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene-1,2,4-triol + O2 = 3-hydroxy-cis,cis-muconate." [EC:1.13.11.37] synonym: "benzene-1,2,4-triol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.37] synonym: "hydroxyquinol dioxygenase activity" EXACT [EC:1.13.11.37] xref: EC:1.13.11.37 xref: MetaCyc:HYDROXYQUINOL-12-DIOXYGENASE-RXN xref: RHEA:19441 xref: UM-BBD_reactionID:r0232 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018582 name: 1-hydroxy-2-naphthoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 = (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate." [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate dioxygenase activity" EXACT [] synonym: "1-hydroxy-2-naphthoate-degrading enzyme activity" NARROW [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.38] synonym: "1-hydroxy-2-naphthoic acid dioxygenase activity" EXACT [EC:1.13.11.38] xref: EC:1.13.11.38 xref: MetaCyc:1.13.11.38-RXN xref: RHEA:14749 xref: UM-BBD_reactionID:r0486 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018583 name: biphenyl-2,3-diol 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl-2,3-diol + O2 = 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate + H2O." [EC:1.13.11.39] synonym: "2,3-dihydroxybiphenyl 1,2-dioxygenase activity" BROAD [] synonym: "2,3-dihydroxybiphenyl dioxygenase activity" BROAD [EC:1.13.11.39] synonym: "biphenyl-2,3-diol dioxygenase activity" EXACT [EC:1.13.11.39] synonym: "biphenyl-2,3-diol:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.39] xref: EC:1.13.11.39 xref: MetaCyc:BIPHENYL-23-DIOL-12-DIOXYGENASE-RXN xref: RHEA:14413 xref: UM-BBD_enzymeID:e0127 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0018584 name: 2,4,5-trichlorophenoxyacetic acid oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,5-trichlorophenoxyacetic acid + 1/2 O2 = glyoxylate + 2,4,5-trichlorophenol." [UM-BBD_reactionID:r0359] xref: EC:1.13.99 xref: UM-BBD_reactionID:r0359 is_a: GO:0016701 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [Term] id: GO:0018585 name: fluorene oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: fluorene + 2 H+ + 2 e- + O2 = H2O + 9-fluorenol." [UM-BBD_reactionID:r0407] xref: EC:1.14 xref: UM-BBD_reactionID:r0407 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018586 name: mono-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyltin." [UM-BBD_reactionID:r0647] synonym: "MBT dioxygenase activity" EXACT [] xref: EC:1.14 xref: UM-BBD_reactionID:r0647 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018587 name: obsolete limonene 8-monooxygenase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "limonene 8-monooxygenase activity" EXACT [] xref: EC:1.14 xref: UM-BBD_enzymeID:e0466 is_obsolete: true replaced_by: GO:0019113 [Term] id: GO:0018588 name: tri-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tri-n-butyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutyldibutyltin." [UM-BBD_reactionID:r0643] synonym: "TBT dioxygenase activity" EXACT [] xref: EC:1.14 xref: UM-BBD_reactionID:r0643 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018589 name: di-n-butyltin dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibutyltin + O2 + 2 H+ + 2 e- = H2O + beta-hydroxybutylbutyltin." [UM-BBD_reactionID:r0645] synonym: "DBT dioxygenase activity" EXACT [] xref: EC:1.14 xref: UM-BBD_reactionID:r0645 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018590 name: methylsilanetriol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: methylsilanetriol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylsilanetriol." [UM-BBD_reactionID:r0640] xref: EC:1.14 xref: UM-BBD_reactionID:r0640 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018591 name: methyl tertiary butyl ether 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methyl tert-butyl ether + 1/2 O2 = tert-butyl alcohol + formaldehyde." [UM-BBD_reactionID:r1023] synonym: "MTBE 3-monooxygenase activity" EXACT [] xref: EC:1.14 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018592 name: 4-nitrocatechol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrocatechol + O2 + 4 e- + 3 H+ = H2O + nitrite + 1,2,4-benzenetriol." [UM-BBD_reactionID:r0231] xref: EC:1.14.13.166 xref: UM-BBD_reactionID:r0231 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018593 name: 4-chlorophenoxyacetate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenoxyacetate + 1/2 O2 = glyoxylate + 4-chlorophenol." [UM-BBD_reactionID:r0281] xref: EC:1.14 xref: UM-BBD_reactionID:r0281 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018594 name: tert-butanol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: tert-butanol + 1/2 O2 = 2-methyl-2-hydroxy-1-propanol." [UM-BBD_reactionID:r0615] synonym: "tert-butyl alcohol 2-monooxygenase activity" EXACT [] xref: EC:1.14 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018595 name: alpha-pinene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + pinocarveol." [UM-BBD_reactionID:r0716] xref: EC:1.14.13.155 xref: RHEA:32891 xref: UM-BBD_reactionID:r0716 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018596 name: dimethylsilanediol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylsilanediol + O2 + 2 H+ + 2 e- = H2O + hydroxymethylmethylsilanediol." [UM-BBD_reactionID:r0637] synonym: "DMSD hydroxylase activity" EXACT [] xref: EC:1.14 xref: UM-BBD_reactionID:r0637 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018597 name: ammonia monooxygenase activity namespace: molecular_function def: "Catalysis of the oxidation of alkanes (up to C8) to alcohols and alkenes (up to C5) to epoxides and alcohols in the presence of ammonium ions." [PMID:16347810] xref: EC:1.14.99.39 xref: RHEA:27341 xref: UM-BBD_enzymeID:e0061 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018598 name: hydroxymethylsilanetriol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylsilanetriol + O2 + 2 H+ + 2 e- = 2 H2O + formylsilanetriol." [UM-BBD_reactionID:r0641] xref: EC:1.14 xref: UM-BBD_reactionID:r0641 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018599 name: 2-hydroxyisobutyrate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + 1/2 O2 = 2,3-dihydroxy-2-methyl propionate." [UM-BBD_reactionID:r0619] xref: EC:1.14 xref: UM-BBD_reactionID:r0619 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018600 name: alpha-pinene dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + O2 + 2 H+ + 2 e- = H2O + myrtenol." [UM-BBD_reactionID:r0709] xref: EC:1.14 xref: UM-BBD_reactionID:r0709 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018601 name: 4-nitrophenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenol + H(+) + NADH + O(2) = 4-nitrocatechol + H(2)O + NAD(+)." [EC:1.14.13.29, RHEA:12568] synonym: "4-nitrophenol hydroxylase activity" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.29] synonym: "4-nitrophenol-2-hydroxylase activity" EXACT [EC:1.14.13.29] xref: EC:1.14.13.29 xref: KEGG:R03023 xref: MetaCyc:4-NITROPHENOL-2-MONOOXYGENASE-RXN xref: RHEA:12568 xref: UM-BBD_reactionID:r0230 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018602 name: 2,4-dichlorophenoxyacetate alpha-ketoglutarate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetate + 2-oxoglutarate + oxygen = 2,4-dichlorophenol + glyoxylate + succinate + CO2." [UM-BBD_reactionID:r0274] xref: EC:1.14.11 xref: MetaCyc:RXN-9863 xref: UM-BBD_reactionID:r0274 is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity [Term] id: GO:0018603 name: nitrobenzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: nitrobenzene + NADH + O2 = NAD+ + nitrite + catechol." [UM-BBD_reactionID:r0306] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0306 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018604 name: 4-aminobenzoate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + 2 H+ + O2 + 2 e- = NH3 + 3,4-dihydroxybenzoate." [UM-BBD_reactionID:r0566] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0566 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018606 name: benzenesulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 + H+ = NAD+ + HSO3(-) + 4-methylcatechol." [UM-BBD_reactionID:r0295] synonym: "benzenesulphonate dioxygenase activity" EXACT [] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0295 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018607 name: 1-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3,4-dihydrocoumarin." [UM-BBD_reactionID:r0417] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0417 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018608 name: 1-indanone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-indanone + NADPH + 1/2 O2 = NADP+ + 3-hydroxy-1-indanone." [UM-BBD_reactionID:r0416] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0416 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018609 name: chlorobenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-unsubstituted benzenoid + O2 + NAD(P)H + H+ = 2,3-cis-dihydroxydihydrobenzenoid + NAD(P)+. Substrates include 1,4-dichlorobenzene (forms 3,6-dichloro-cis-1,2-dihydroxycyclohexa-3,5-diene), 1,2,3,4-tetrachlorobenzene (forms cis-chlorobenzene dihydrodiol) and 1,2,4-trichlorobenzene (forms 3,4,6-trichloro-cis-1,2-dihydroxycyclohexa-3,5-diene)." [UM-BBD_enzymeID:e0062] xref: EC:1.14.12 xref: UM-BBD_enzymeID:e0062 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018610 name: dibenzofuran 4,4a-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzofuran + NADH + H+ + O2 = 2,2',3-trihydroxybiphenyl + NAD+." [MetaCyc:R606-RXN] xref: EC:1.14.12 xref: MetaCyc:R606-RXN xref: UM-BBD_enzymeID:e0030 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018611 name: toluate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methylbenzoate + NADH + O2 + H+ = NAD+ + 1,2-dihydroxymethylcyclohexa-3,5-dienecarboxylate." [UM-BBD_enzymeID:e0190] xref: EC:1.14.12 xref: UM-BBD_enzymeID:e0190 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018612 name: dibenzothiophene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + O2 + H+ = NAD+ + cis-1,2-dihydroxy-1,2-dihydrodibenzothiophene." [UM-BBD_reactionID:r0160] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0160 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018613 name: 9-fluorenone dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 9-fluorenone + 2 NADPH + O2 = 2 NADP+ + 3,4-dihydroxy-3,4-dihydro-9-fluorenone." [UM-BBD_reactionID:r0409] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0409 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018614 name: ethylbenzene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ethylbenzene + O2 + NADH + H+ = NAD+ + cis-2,3-dihydroxy-2,3-dihydroethylbenzene." [UM-BBD_reactionID:r0247] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0247 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018615 name: 2-indanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-indanone + NADPH + 1/2 O2 = NADP+ + 3-isochromanone." [UM-BBD_reactionID:r0424] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0424 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018616 name: trihydroxytoluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,5-trihydroxytoluene + O2 = 2,4,6-trioxoheptanoate." [MetaCyc:R305-RXN, UM-BBD_reactionID:r0093] xref: EC:1.14.12 xref: MetaCyc:R305-RXN xref: UM-BBD_reactionID:r0093 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018617 name: 4-aminobenzenesulfonate 3,4-dioxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzenesulfonate + 2 H+ + O2 + 2 e- = NH3 + 4-sulfocatechol." [UM-BBD_reactionID:r0580] synonym: "4-aminobenzenesulphonate 3,4-dioxygenase (deaminating) activity" EXACT [] xref: EC:1.14.12 xref: UM-BBD_reactionID:r0580 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018618 name: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + NADPH + H+ + O2 = catechol + CO2 + NADP+ + NH3." [EC:1.14.12.1] synonym: "AntA" RELATED [] synonym: "AntB" RELATED [] synonym: "AntC" RELATED [] synonym: "anthranilate 1,2-dioxygenase" RELATED [] synonym: "anthranilate dioxygenase activity" EXACT [] synonym: "anthranilate dioxygenase reductase" NARROW [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilate,NAD(P)H:oxygen oxidoreductase (1,2-hydroxylating, deaminating, decarboxylating)" EXACT [EC:1.14.12.1] synonym: "anthranilic acid hydroxylase activity" BROAD [EC:1.14.12.1] synonym: "anthranilic hydroxylase activity" BROAD [EC:1.14.12.1] xref: EC:1.14.12.1 xref: MetaCyc:1.14.12.1-RXN xref: UM-BBD_reactionID:r0577 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018619 name: benzene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzene + H(+) + NADH + O(2) = cis-cyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.3, RHEA:13813] synonym: "benzene dioxygenase activity" EXACT [EC:1.14.12.3] synonym: "benzene hydroxylase activity" RELATED [EC:1.14.12.3] synonym: "benzene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.3] xref: EC:1.14.12.3 xref: KEGG:R03543 xref: MetaCyc:BENZENE-12-DIOXYGENASE-RXN xref: RHEA:13813 xref: UM-BBD_reactionID:r0079 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018620 name: phthalate 4,5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + phthalate = cis-4,5-dihydroxycyclohexa-2,6-diene-1,2-dicarboxylate + NAD(+)." [EC:1.14.12.7, RHEA:17489] synonym: "PDO activity" EXACT [EC:1.14.12.7] synonym: "phthalate dioxygenase activity" BROAD [EC:1.14.12.7] synonym: "phthalate,NADH:oxygen oxidoreductase (4,5-hydroxylating)" EXACT [EC:1.14.12.7] xref: EC:1.14.12.7 xref: KEGG:R03630 xref: MetaCyc:PHTHALATE-45-DIOXYGENASE-RXN xref: RHEA:17489 xref: UM-BBD_reactionID:r0102 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018621 name: 4-sulfobenzoate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfobenzoate + H(+) + NADH + O(2) = 3,4-dihydroxybenzoate + NAD(+) + sulfite." [EC:1.14.12.8, RHEA:13937] synonym: "4-sulfobenzoate 3,4-dioxygenase system" RELATED [EC:1.14.12.8] synonym: "4-sulfobenzoate dioxygenase activity" EXACT [EC:1.14.12.8] synonym: "4-sulfobenzoate,NADH:oxygen oxidoreductase (3,4-hydroxylating, sulfite-forming)" EXACT [EC:1.14.12.8] synonym: "4-sulphobenzoate 3,4-dioxygenase activity" EXACT [] xref: EC:1.14.12.8 xref: KEGG:R01636 xref: MetaCyc:4-SULFOBENZOATE-34-DIOXYGENASE-RXN xref: RHEA:13937 xref: UM-BBD_reactionID:r0293 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018622 name: 4-chlorophenylacetate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorophenylacetate + NADH + O(2) = 3,4-dihydroxyphenylacetate + chloride + NAD(+)." [EC:1.14.12.9, RHEA:14689] synonym: "4-chlorophenylacetate,NADH:oxygen oxidoreductase (3,4-hydroxylating, dechlorinating)" EXACT [EC:1.14.12.9] xref: EC:1.14.12.9 xref: KEGG:R03306 xref: MetaCyc:1.14.12.9-RXN xref: RHEA:14689 xref: UM-BBD_reactionID:r0308 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018623 name: benzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + NADH + H+ + O2 = catechol + CO2 + NAD+." [EC:1.14.12.10] synonym: "benzoate dioxygenase activity" EXACT [EC:1.14.12.10] synonym: "benzoate hydroxylase activity" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.10] synonym: "benzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, decarboxylating)" EXACT [EC:1.14.12.10] synonym: "benzoic hydroxylase activity" EXACT [EC:1.14.12.10] xref: EC:1.14.12.10 xref: MetaCyc:BENZOATE-12-DIOXYGENASE-RXN xref: RHEA:12633 xref: UM-BBD_enzymeID:e0154 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018624 name: toluene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + toluene = (1S,2R)-3-methylcyclohexa-3,5-diene-1,2-diol + NAD(+)." [EC:1.14.12.11, RHEA:16737] synonym: "toluene 1,2-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene 2,3-dioxygenase activity" EXACT [EC:1.14.12.11] synonym: "toluene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.11] xref: EC:1.14.12.11 xref: KEGG:R03559 xref: MetaCyc:TOLUENE-DIOXYGENASE-RXN xref: RHEA:16737 xref: UM-BBD_enzymeID:e0155 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018625 name: naphthalene 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: naphthalene + NADH + H+ + O2 = (1R,2S)-1,2-dihydronaphthalene-1,2-diol + NAD+." [EC:1.14.12.12] synonym: "naphthalene dioxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene oxygenase activity" EXACT [EC:1.14.12.12] synonym: "naphthalene,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.12] xref: EC:1.14.12.12 xref: MetaCyc:NAPHTHALENE-12-DIOXYGENASE-RXN xref: RHEA:19173 xref: UM-BBD_enzymeID:e0002 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018626 name: 2-chlorobenzoate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chlorobenzoate + NADH + H+ + O2 = catechol + chloride + NAD+ + CO2." [EC:1.14.12.13] synonym: "2-chlorobenzoate,NADH:oxygen oxidoreductase (1,2-hydroxylating, dechlorinating, decarboxylating)" EXACT [EC:1.14.12.13] synonym: "2-halobenzoate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.12.13 xref: MetaCyc:2-CHLOROBENZOATE-12-DIOXYGENASE-RXN xref: RHEA:21652 xref: UM-BBD_reactionID:r0632 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018627 name: 2-aminobenzenesulfonate 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0018605 def: "Catalysis of the reaction: 2-aminobenzenesulfonate + 2 H(+) + NADH + O(2) = 2,3-dihydroxybenzenesulfonate + NAD(+) + NH(4)(+). 2,3-dihydroxybenzenesulfonate is also known as 3-sulfocatechol." [EC:1.14.12.14, RHEA:23468] synonym: "2-aminobenzenesulfonate dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulfonate,NADH:oxygen oxidoreductase (2,3-hydroxylating, ammonia-forming)" EXACT [EC:1.14.12.14] synonym: "2-aminobenzenesulphonate 2,3-dioxygenase activity" EXACT [] synonym: "2-aminobenzenesulphonate dioxygenase activity" EXACT [] synonym: "2-aminosulfobenzene 2,3-dioxygenase activity" EXACT [EC:1.14.12.14] xref: EC:1.14.12.14 xref: KEGG:R05156 xref: MetaCyc:2ASDOSALCAL-RXN xref: RHEA:23468 xref: UM-BBD_reactionID:r0218 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018628 name: terephthalate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + terephthalate = (3S,4R)-3,4-dihydroxycyclohexa-1,5-diene-1,4-dicarboxylate + NAD(+)." [EC:1.14.12.15, RHEA:10312] synonym: "1,4-dicarboxybenzoate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate 1,2-dioxygenase activity" EXACT [EC:1.14.12.15] synonym: "benzene-1,4-dicarboxylate,NADH:oxygen oxidoreductase (1,2-hydroxylating)" EXACT [EC:1.14.12.15] xref: EC:1.14.12.15 xref: KEGG:R05148 xref: MetaCyc:1.14.12.15-RXN xref: RHEA:10312 xref: UM-BBD_reactionID:r0150 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018629 name: 2-hydroxyquinoline 5,6-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quinolin-2-ol + NADH + H+ + O2 = 2,5,6-trihydroxy-5,6-dihydroquinoline + NAD+." [EC:1.14.12.16] synonym: "2-oxo-1,2-dihydroquinoline 5,6-dioxygenase activity" EXACT [] synonym: "quinolin-2(1H)-one 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol 5,6-dioxygenase activity" EXACT [EC:1.14.12.16] synonym: "quinolin-2-ol,NADH:oxygen oxidoreductase (5,6-hydroxylating)" EXACT [EC:1.14.12.16] xref: EC:1.14.12.16 xref: MetaCyc:1.14.12.16-RXN xref: RHEA:10976 xref: UM-BBD_reactionID:r0052 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018630 name: 3,5-xylenol methylhydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxytoluene + NADH + O2 = NAD+ + OH- + 3-hydroxybenzyl alcohol." [UM-BBD_reactionID:r0081] xref: EC:1.14.13 xref: MetaCyc:3-5-XYLENOL-METHYLHYDROXYLASE-RXN xref: UM-BBD_reactionID:r0081 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018631 name: phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetate + NADH + O2 = NAD+ + OH- + 2-hydroxyphenylacetate." [UM-BBD_reactionID:r0036] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0036 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018632 name: 4-nitrophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: p-nitrophenol + O2 + NADPH = H2O + NADP+ + nitrite + p-benzoquinone." [UM-BBD_reactionID:r0226] xref: EC:1.14.13 xref: MetaCyc:RXN-8739 xref: UM-BBD_reactionID:r0226 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018633 name: dimethyl sulfide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfide + NADH + O2 = NAD+ + OH- + methanethiol + formaldehyde." [UM-BBD_reactionID:r0208] synonym: "dimethyl sulphide monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018634 name: alpha-pinene monooxygenase [NADH] activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene + NADH + H+ + O2 = NAD+ + H2O + alpha-pinene oxide." [UM-BBD_reactionID:r0742] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0742 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018635 name: (R)-limonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4R)-limonene + NAD(P)H + H+ + O2 = NAD(P)+ + H2O + (4R)-limonene-1,2-epoxide." [UM-BBD_enzymeID:e0462] synonym: "(+)-limonene 1,2-monooxygenase activity" EXACT [EC:1.14.13.107] synonym: "(+)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] synonym: "(R)-limonene,NAD(P)H:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.107] xref: EC:1.14.13.107 xref: KEGG:R06398 "limonene,NADH:oxygen oxidoreductase" xref: KEGG:R09393 "limonene,NADPH:oxygen oxidoreductase" xref: MetaCyc:RXN-9407 xref: RHEA:26093 xref: RHEA:26097 xref: UM-BBD_reactionID:r0733 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018636 name: phenanthrene 9,10-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-9,10-oxide." [UM-BBD_reactionID:r0495] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0495 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018637 name: 1-hydroxy-2-naphthoate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 1-hydroxy-2-naphthoate + O2 + NADPH + 2 H+ = NADP+ + H2O + CO2 + 1,2-dihydroxynaphthalene." [UM-BBD_reactionID:r0491] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0491 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018638 name: toluene 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 4-hydroxytoluene." [UM-BBD_enzymeID:e0225] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018639 name: xylene monooxygenase activity namespace: molecular_function def: "Catalysis of the reactions: toluene + 1/2 O2 = benzyl alcohol, and xylene + 1/2 O2 = methylbenzyl alcohol." [UM-BBD_enzymeID:e0172] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0172 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018640 name: dibenzothiophene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene + NADH + H+ + O2 = dibenzothiophene-5-oxide + NAD+ + H2O." [MetaCyc:RXN-621] xref: EC:1.14.13 xref: MetaCyc:RXN-621 xref: UM-BBD_enzymeID:e0214 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018641 name: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 5,6-dihydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [UM-BBD_reactionID:r0048] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0048 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018642 name: chlorophenol 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the addition or substitution of an OH group on C4 of a halogenated phenol." [UM-BBD_enzymeID:e0252] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018643 name: carbon disulfide oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: carbon disulfide + NADH + H+ + O2 = [S] + H2O + NAD+ + carbonyl sulfide." [UM-BBD_reactionID:r0599] synonym: "carbon disulphide oxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0599 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018644 name: toluene 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 2-hydroxytoluene." [UM-BBD_enzymeID:e0222] xref: EC:1.14.13 xref: MetaCyc:TOLUENE-2-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0222 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018645 name: alkene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: propene + NADH + H+ + O2 = 1,2-epoxypropane + NAD+ + H2O." [EC:1.14.13.69] synonym: "alkene epoxygenase activity" EXACT [EC:1.14.13.69] synonym: "alkene,NADH:oxygen oxidoreductase activity" EXACT [EC:1.14.13.69] xref: EC:1.14.13.69 xref: MetaCyc:1.14.13.69-RXN xref: RHEA:11792 xref: UM-BBD_enzymeID:e0039 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018646 name: 1-hydroxy-2-oxolimonene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1S,4R)-1-hydroxy-2-oxolimonene + NADPH + O2 = NADP+ + OH- + (3R)-3-isopropenyl-6-oxoheptanoate." [UM-BBD_reactionID:r0736] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0736 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018647 name: phenanthrene 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-1,2-oxide." [UM-BBD_enzymeID:e0333] xref: EC:1.14.13 xref: UM-BBD_enzymeID:e0333 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018648 name: methanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: methanesulfonate + NADH + H+ + O2 = formaldehyde + NAD+ + sulfite + H2O." [EC:1.14.13.111] synonym: "mesylate monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,FMNH2:oxygen oxidoreductase activity" EXACT [EC:1.14.13.111] synonym: "methanesulfonate,NADH:oxygen oxidoreductase activity" EXACT systematic_synonym [EC:1.14.13.111] synonym: "methanesulfonic acid monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "methanesulphonic acid monooxygenase activity" EXACT [GOC:mah] synonym: "MSA monooxygenase activity" EXACT [EC:1.14.13.111] synonym: "MSAMO activity" EXACT [EC:1.14.13.111] xref: EC:1.14.13.111 xref: MetaCyc:RXN-9770 xref: RHEA:26077 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018649 name: tetrahydrofuran hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrofuran + O2 + 2 H+ + 2 e- = H2O + 2-hydroxytetrahydrofuran." [UM-BBD_reactionID:r0017] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0017 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018650 name: styrene monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: styrene + NADPH + FADH + O2 = NADP+ + FAD+ + H2O + styrene oxide." [UM-BBD_reactionID:r0225] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0225 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018651 name: toluene-4-sulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + 1/2 O2 + H+ = HSO3(-) + 4-hydroxytoluene." [UM-BBD_reactionID:r0296] synonym: "toluene-4-sulphonate monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0296 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018652 name: toluene-sulfonate methyl-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene-4-sulfonate + NADH + O2 = NAD+ + OH- + 4-sulfobenzyl alcohol." [UM-BBD_reactionID:r0290] synonym: "toluene-sulphonate methyl-monooxygenase activity" EXACT [] xref: EC:1.14.13 xref: MetaCyc:TSMOS-RXN xref: UM-BBD_reactionID:r0290 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018653 name: 3-methyl-2-oxo-1,2-dihydroquinoline 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxo-1,2-dihydroquinoline + O2 + 2 H+ + 2 e- = H2O + 6-hydroxy-3-methyl-2-oxo-1,2-dihydroquinoline." [EC:1.14.13.-] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0046 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018654 name: 2-hydroxy-phenylacetate hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyphenylacetate + NADH + O2 = NAD+ + OH- + homogentisate." [UM-BBD_reactionID:r0252] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0252 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018655 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA + NADH + H+ + O2 = NAD+ + H2O + delta2,5-3,4,4-trimethylpimelyl-CoA." [UM-BBD_reactionID:r0430] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0430 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018656 name: phenanthrene 3,4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene + O2 + NADH + H+ = H2O + NAD+ + phenanthrene-3,4-oxide." [UM-BBD_reactionID:r0508] xref: EC:1.14.13 xref: UM-BBD_reactionID:r0508 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018657 name: toluene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: toluene + 1/2 O2 = 3-hydroxytoluene." [UM-BBD_enzymeID:e0224] xref: EC:1.14.13 xref: MetaCyc:TOLUENE-3-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0224 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018658 name: salicylate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: salicylate + NADH + H+ + O2 = catechol + NAD+ + H2O + CO2." [EC:1.14.13.1] synonym: "salicylate 1-hydroxylase activity" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase (decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylate hydroxylase activity" EXACT [] synonym: "salicylate monooxygenase activity" EXACT [EC:1.14.13.1] synonym: "salicylate,NADH:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.1] synonym: "salicylic hydroxylase activity" EXACT [EC:1.14.13.1] xref: EC:1.14.13.1 xref: MetaCyc:SALICYLATE-1-MONOOXYGENASE-RXN xref: RHEA:11004 xref: UM-BBD_enzymeID:e0149 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018659 name: 4-hydroxybenzoate 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = protocatechuate + NADP+ + H2O." [EC:1.14.13.2] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "4-hydroxybenzoate monooxygenase activity" EXACT [EC:1.14.13.2] synonym: "4-hydroxybenzoate,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydrolyase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydrolase activity" EXACT [EC:1.14.13.2] synonym: "p-hydroxybenzoic acid hydroxylase activity" BROAD [EC:1.14.13.2] synonym: "p-hydroxybenzoic hydroxylase activity" EXACT [EC:1.14.13.2] synonym: "para-hydroxybenzoate hydroxylase activity" BROAD [EC:1.14.13.2] xref: EC:1.14.13.2 xref: MetaCyc:4-HYDROXYBENZOATE-3-MONOOXYGENASE-RXN xref: RHEA:19477 xref: UM-BBD_reactionID:r0109 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018660 name: 4-hydroxyphenylacetate,NADH:oxygen oxidoreductase (3-hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADH + H+ + O2 = 3,4-dihydroxyphenylacetate + NAD+ + H2O." [KEGG:R02698] synonym: "4 HPA 3-hydroxylase activity" BROAD [EC:1.14.13.3] synonym: "4-hydroxyphenylacetate 3-hydroxylase activity" BROAD [] synonym: "4-hydroxyphenylacetate 3-monooxygenase activity" BROAD [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate 3-hydroxylase activity" BROAD [EC:1.14.13.3] synonym: "p-hydroxyphenylacetate hydroxylase activity" BROAD [EC:1.14.13.3] xref: EC:1.14.13 xref: KEGG:R02698 xref: RHEA:16681 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018661 name: orcinol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: H(+) + NADH + O(2) + orcinol = 2,3,5-trihydroxytoluene + H(2)O + NAD(+)." [EC:1.14.13.6, RHEA:19601] synonym: "orcinol hydroxylase activity" EXACT [] synonym: "orcinol,NADH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.6] xref: EC:1.14.13.6 xref: KEGG:R02830 xref: MetaCyc:ORCINOL-2-MONOOXYGENASE-RXN xref: RHEA:19601 xref: UM-BBD_reactionID:r0092 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018662 name: phenol 2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + NADPH + H+ + O2 = catechol + NADP+ + H2O." [EC:1.14.13.7] synonym: "phenol hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol o-hydroxylase activity" EXACT [EC:1.14.13.7] synonym: "phenol,NADPH:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.13.7] xref: EC:1.14.13.7 xref: MetaCyc:PHENOL-2-MONOOXYGENASE-RXN xref: RHEA:17061 xref: UM-BBD_enzymeID:e0208 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018663 name: 2,6-dihydroxypyridine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dihydroxypyridine + H(+) + NADH + O(2) = 2,3,6-trihydroxypyridine + H(2)O + NAD(+)." [EC:1.14.13.10, RHEA:16917] synonym: "2,6-dihydroxypyridine oxidase activity" EXACT [] synonym: "2,6-dihydroxypyridine,NADH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.10] xref: EC:1.14.13.10 xref: KEGG:R04130 xref: MetaCyc:1.14.13.10-RXN xref: RHEA:16917 xref: UM-BBD_reactionID:r0479 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018664 name: benzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: benzoate + H(+) + NADPH + O(2) = 4-hydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.12, RHEA:18033] synonym: "4-hydroxybenzoic hydroxylase activity" EXACT [] synonym: "benzoate 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.12] synonym: "benzoate-p-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoate-para-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "benzoic acid 4-hydroxylase activity" EXACT [EC:1.14.13.12] synonym: "p-hydroxybenzoate hydroxylase activity" EXACT [EC:1.14.13.12] xref: EC:1.14.13.12 xref: KEGG:R01295 xref: MetaCyc:BENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:18033 xref: UM-BBD_reactionID:r0623 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018665 name: 4-hydroxyphenylacetate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylacetate + NADPH + H+ + O2 = homogentisate + NADP+ + H2O." [EC:1.14.13.18] synonym: "4-HPA 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenyl-acetate 1-hydroxylase activity" EXACT [] synonym: "4-hydroxyphenylacetate 1-hydroxylase activity" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.18] synonym: "4-hydroxyphenylacetic 1-hydroxylase activity" EXACT [EC:1.14.13.18] xref: EC:1.14.13.18 xref: MetaCyc:1.14.13.18-RXN xref: UM-BBD_reactionID:r0300 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018666 name: 2,4-dichlorophenol 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenol + NADPH + H+ + O2 = 3,5-dichlorocatechol + NADP+ + H2O." [EC:1.14.13.20] synonym: "2,4-dichlorophenol hydroxylase activity" EXACT [] synonym: "2,4-dichlorophenol monooxygenase activity" EXACT [EC:1.14.13.20] synonym: "2,4-dichlorophenol,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.20] xref: EC:1.14.13.20 xref: MetaCyc:24-DICHLOROPHENOL-6-MONOOXYGENASE-RXN xref: RHEA:20920 xref: UM-BBD_enzymeID:e0152 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018667 name: cyclohexanone monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexanone + NADPH + H+ + O2 = 6-hexanolide + NADP+ + H2O." [EC:1.14.13.22] synonym: "cyclohexanone 1,2-monooxygenase activity" EXACT [] synonym: "cyclohexanone oxygenase activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (6-hydroxylating, 1,2-lactonizing) activity" EXACT [EC:1.14.13.22] synonym: "cyclohexanone:NADPH:oxygen oxidoreductase (lactone-forming)" EXACT [EC:1.14.13.22] xref: EC:1.14.13.22 xref: MetaCyc:CYCLOHEXANONE-MONOOXYGENASE-RXN xref: RHEA:24068 xref: UM-BBD_reactionID:r0166 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018668 name: 3-hydroxybenzoate 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADPH + O(2) = 3,4-dihydroxybenzoate + H(2)O + NADP(+)." [EC:1.14.13.23, RHEA:11480] synonym: "3-hydroxybenzoate 4-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADPH:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.13.23] xref: EC:1.14.13.23 xref: KEGG:R01628 xref: MetaCyc:3-HYDROXYBENZOATE-4-MONOOXYGENASE-RXN xref: RHEA:11480 xref: UM-BBD_reactionID:r0153 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018669 name: 3-hydroxybenzoate 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxybenzoate + H(+) + NADH + O(2) = 2,5-dihydroxybenzoate + H(2)O + NAD(+)." [EC:1.14.13.24, RHEA:22692] synonym: "3-hydroxybenzoate 6-hydroxylase activity" EXACT [] synonym: "3-hydroxybenzoate,NADH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.24] synonym: "3-hydroxybenzoic acid-6-hydroxylase activity" EXACT [EC:1.14.13.24] synonym: "m-hydroxybenzoate 6-hydroxylase activity" EXACT [EC:1.14.13.24] xref: EC:1.14.13.24 xref: KEGG:R02589 xref: MetaCyc:3-HYDROXYBENZOATE-6-MONOOXYGENASE-RXN xref: RHEA:22692 xref: UM-BBD_reactionID:r0402 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018670 name: 4-aminobenzoate 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobenzoate + NADPH + H+ + O2 = 4-hydroxyaniline + NADP+ + H2O + CO2." [EC:1.14.13.27] synonym: "4-aminobenzoate dehydrogenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate hydroxylase activity" EXACT [] synonym: "4-aminobenzoate monooxygenase activity" EXACT [EC:1.14.13.27] synonym: "4-aminobenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.27] xref: EC:1.14.13.27 xref: MetaCyc:4-AMINOBENZOATE-1-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0597 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018671 name: 4-hydroxybenzoate 3-monooxygenase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NAD(P)H + H+ + O2 = 3,4-dihydroxybenzoate + NAD(P)+ + H2O." [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-hydroxylase activity" BROAD [EC:1.14.13.33] synonym: "4-hydroxybenzoate 3-monooxygenase (reduced nicotinamide adenine dinucleotide (phosphate))" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.33] synonym: "4-hydroxybenzoate-3-hydroxylase activity" EXACT [EC:1.14.13.33] xref: EC:1.14.13.33 xref: MetaCyc:1.14.13.33-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018672 name: anthranilate 3-monooxygenase (deaminating) activity namespace: molecular_function def: "Catalysis of the reaction: anthranilate + 2 H(+) + NADPH + O(2) = 2,3-dihydroxybenzoate + NADP(+) + NH(4)(+)." [EC:1.14.13.35, RHEA:21236] synonym: "anthranilate 2,3-dioxygenase (deaminating)" EXACT [EC:1.14.13.35] synonym: "anthranilate 2,3-hydroxylase (deaminating) activity" EXACT [EC:1.14.13.35] synonym: "anthranilate hydroxylase (deaminating) activity" EXACT [] synonym: "anthranilate hydroxylase activity" BROAD [EC:1.14.13.35] synonym: "anthranilate,NADPH:oxygen oxidoreductase (3-hydroxylating, deaminating)" EXACT [EC:1.14.13.35] xref: EC:1.14.13.35 xref: KEGG:R00980 xref: MetaCyc:1.14.13.35-RXN xref: RHEA:21236 xref: UM-BBD_reactionID:r0578 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018673 name: anthraniloyl-CoA monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-aminobenzoyl-CoA + 2 NADPH + 2 H+ + O2 = 2-amino-5-oxocyclohex-1-enecarboxyl-CoA + H2O + 2 NADP+." [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA monooxygenase/reductase activity" EXACT [EC:1.14.13.40] synonym: "2-aminobenzoyl-CoA,NAD(P)H:oxygen oxidoreductase (de-aromatizing)" EXACT [EC:1.14.13.40] synonym: "anthraniloyl coenzyme A reductase activity" EXACT [EC:1.14.13.40] xref: EC:1.14.13.40 xref: MetaCyc:ANTHRANILOYL-COA-MONOOXYGENASE-RXN xref: UM-BBD_reactionID:r0568 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018674 name: (S)-limonene 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (1S,6R)-isopiperitenol + H(2)O + NADP(+)." [EC:1.14.13.47, RHEA:15129] synonym: "(-)-limonene 3-hydroxylase activity" EXACT [EC:1.14.13.47] synonym: "(-)-limonene 3-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.13.47] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.47] synonym: "limonene 3-hydroxylase activity" EXACT [] xref: EC:1.14.13.47 xref: KEGG:R02469 xref: MetaCyc:--LIMONENE-3-MONOOXYGENASE-RXN xref: RHEA:15129 xref: UM-BBD_reactionID:r0739 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018675 name: (S)-limonene 6-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-limonene + NADPH + H+ + O2 = (-)-trans-carveol + NADP+ + H2O." [EC:1.14.13.48] synonym: "(-)-limonene 6-hydroxylase activity" EXACT [EC:1.14.13.48] synonym: "(-)-limonene 6-monooxygenase activity" EXACT [] synonym: "(-)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating) activity" EXACT [EC:1.14.13.48] synonym: "(S)-limonene,NADPH:oxygen oxidoreductase (6-hydroxylating)" EXACT [EC:1.14.13.48] synonym: "limonene 6-hydroxylase activity" EXACT [] xref: EC:1.14.13.48 xref: MetaCyc:--LIMONENE-6-MONOOXYGENASE-RXN xref: RHEA:17945 xref: UM-BBD_reactionID:r0713 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018676 name: (S)-limonene 7-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (4S)-limonene + H(+) + NADPH + O(2) = (4S)-perillyl alcohol + H(2)O + NADP(+)." [EC:1.14.13.49, RHEA:23432] synonym: "(-)-limonene 7-monooxygenase activity" EXACT [] xref: EC:1.14.13.49 xref: KEGG:R02470 xref: MetaCyc:--LIMONENE-7-MONOOXYGENASE-RXN xref: RHEA:23432 xref: UM-BBD_reactionID:r0728 is_a: GO:0019113 ! limonene monooxygenase activity [Term] id: GO:0018677 name: pentachlorophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pentachlorophenol + NADPH + H+ + O2 = tetrachlorohydroquinone + NADP+ + chloride." [EC:1.14.13.50] synonym: "PCB 4-monooxygenase activity" EXACT [EC:1.14.13.50] synonym: "PCB4MO activity" EXACT [EC:1.14.13.50] synonym: "PCP hydroxylase activity" EXACT [EC:1.14.13.50] synonym: "PcpB" RELATED [EC:1.14.13.50] synonym: "pentachlorophenol 4-monooxygenase activity" EXACT [] synonym: "pentachlorophenol dechlorinase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol dehalogenase activity" EXACT [EC:1.14.13.50] synonym: "pentachlorophenol hydroxylase activity" EXACT [] synonym: "pentachlorophenol,NADPH:oxygen oxidoreductase (hydroxylating, dechlorinating)" EXACT [EC:1.14.13.50] xref: EC:1.14.13.50 xref: MetaCyc:PCP4MONO-RXN xref: UM-BBD_enzymeID:e0148 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018678 name: 4-hydroxybenzoate 1-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + NADPH + H+ + O2 = hydroquinone + NADP+ + H2O + CO2." [EC:1.14.13.64] synonym: "4-hydroxybenzoate 1-monooxygenase activity" EXACT [] synonym: "4-hydroxybenzoate,NAD(P)H:oxygen oxidoreductase (1-hydroxylating, decarboxylating)" EXACT [EC:1.14.13.64] xref: EC:1.14.13.64 xref: MetaCyc:1.14.13.64-RXN xref: UM-BBD_reactionID:r0752 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018679 name: dibenzothiophene-5,5-dioxide monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: dibenzothiophene-5,5-dioxide + O2 + 2 NADH + H+ = 2 NAD+ + H2O + 2'-hydroxybiphenyl-2-sulfinate." [UM-BBD_reactionID:r0235] xref: EC:1.14.14 xref: MetaCyc:RXN-623 xref: UM-BBD_reactionID:r0235 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018680 name: deethylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deethylatrazine + O2 = 2 CH3COCH3 + 2 deisopropyldeethylatrazine." [UM-BBD_reactionID:r0128] xref: EC:1.14.15 xref: UM-BBD_reactionID:r0128 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018681 name: deisopropylatrazine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 deisopropylatrazine + O2 = 2 acetaldehyde + 2 deisopropyldeethylatrazine." [KEGG:R05567] xref: EC:1.14.15 xref: KEGG:R05567 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018682 name: atrazine N-dealkylase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + O2 + 2 H+ = deethylatrazine + acetaldehyde + H2O." [MetaCyc:R461-RXN, UM-BBD_reactionID:r0127] synonym: "atrazine monooxygenase activity" RELATED [UM-BBD_enzymeID:e0090] xref: EC:1.14.15 xref: MetaCyc:R461-RXN xref: UM-BBD_reactionID:r0127 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018683 name: camphor 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-camphor + putidaredoxin + O2 = (+)-exo-5-hydroxycamphor + oxidized putidaredoxin + H2O." [EC:1.14.15.1] synonym: "(+)-camphor,reduced putidaredoxin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.15.1] synonym: "2-bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "bornanone 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor 5-exo-methylene hydroxylase activity" EXACT [] synonym: "camphor 5-exohydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "camphor methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "cytochrome p450-cam activity" EXACT [EC:1.14.15.1] synonym: "d-camphor monooxygenase activity" EXACT [EC:1.14.15.1] synonym: "D-camphor-exo-hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene hydroxylase activity" EXACT [EC:1.14.15.1] synonym: "methylene monooxygenase activity" EXACT [EC:1.14.15.1] xref: EC:1.14.15.1 xref: MetaCyc:R541-RXN xref: UM-BBD_enzymeID:e0300 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018684 name: camphor 1,2-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1R)-bornane-2,5-dione + reduced rubredoxin + O2 = 5-oxo-1,2-campholide + oxidized rubredoxin + H2O." [EC:1.14.15.2] synonym: "(+)-camphor,reduced-rubredoxin:oxygen oxidoreductase (1,2-lactonizing)" EXACT [EC:1.14.15.2] synonym: "2,5-diketocamphane lactonizing enzyme activity" EXACT [EC:1.14.15.2] synonym: "camphor ketolactonase I activity" EXACT [EC:1.14.15.2] synonym: "ketolactonase I" RELATED [EC:1.14.15.2] synonym: "oxygenase, camphor 1,2-mono" EXACT [EC:1.14.15.2] xref: EC:1.14.15.2 xref: MetaCyc:CAMPHOR-12-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0302 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018685 name: alkane 1-monooxygenase activity namespace: molecular_function alt_id: GO:0008393 def: "Catalysis of the reaction: octane + reduced rubredoxin + O2 = 1-octanol + oxidized rubredoxin + H2O." [EC:1.14.15.3] synonym: "1-hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane 1-hydroxylase activity" EXACT [] synonym: "alkane hydroxylase activity" EXACT [EC:1.14.15.3] synonym: "alkane monooxygenase activity" EXACT [EC:1.14.15.3] synonym: "alkane,reduced-rubredoxin:oxygen 1-oxidoreductase activity" EXACT [EC:1.14.15.3] synonym: "fatty acid (omega-1)-hydroxylase activity" EXACT [] synonym: "fatty acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "lauric acid omega-hydroxylase activity" NARROW [EC:1.14.15.3] synonym: "omega-hydroxylase activity" RELATED [EC:1.14.15.3] xref: EC:1.14.15.3 xref: MetaCyc:ALKANE-1-MONOOXYGENASE-RXN xref: UM-BBD_enzymeID:e0022 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018686 name: 6-hydroxy pseudo-oxynicotine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6-hydroxypseudooxynicotine + O2 = 2 2,6-dihydroxypseudooxynicotine." [UM-BBD_reactionID:r0480] xref: EC:1.14.18 xref: UM-BBD_reactionID:r0480 is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0018687 name: biphenyl 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: biphenyl + NADH + H+ + O2 = (2R,3S)-3-phenylcyclohexa-3,5-diene-1,2-diol + NAD+. This reaction requires Fe2+." [EC:1.14.12.18] synonym: "biphenyl dioxygenase activity" EXACT [EC:1.14.12.18] synonym: "biphenyl,NADH:oxygen oxidoreductase (2,3-hydroxylating)" EXACT [EC:1.14.12.18] xref: EC:1.14.12.18 xref: MetaCyc:1.14.12.18-RXN xref: RHEA:18165 xref: UM-BBD_enzymeID:e0089 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0018688 name: DDT 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane + O2 + 2 H+ + 2 e- = cis-2,3-dihydrodiol DDT. 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane is also known as DDT." [UM-BBD_reactionID:r0450] xref: EC:1.14.99 xref: UM-BBD_reactionID:r0450 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0051213 ! dioxygenase activity [Term] id: GO:0018689 name: naphthalene disulfonate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: (1/2)-unsubstituted naphthalenoid-(2/1)-sulfonate + 2 H+ + 2 e- + O2 = 1,2-dihydroxynaphthalene derivative + HSO3(-). Substrates include naphthalene-1,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate), naphthalene-1-sulfonate (forms 1,2-dihydroxynaphthalene), naphthalene-2,6-disulfonate (forms 1,2-dihydroxynaphthalene-6-sulfonate) and naphthalene-2-sulfonate (forms 1,2-dihydroxynaphthalene)." [UM-BBD_enzymeID:e0249] synonym: "naphthalene disulphonate 1,2-dioxygenase activity" EXACT [] xref: EC:1.14.99 xref: UM-BBD_enzymeID:e0249 is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018690 name: 4-methoxybenzoate monooxygenase (O-demethylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-methoxybenzoate + AH(2) + O(2) = 4-hydroxybenzoate + A + formaldehyde + H(2)O." [EC:1.14.99.15, RHEA:18613] synonym: "4-methoxybenzoate 4-monooxygenase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate monooxygenase activity" EXACT [] synonym: "4-methoxybenzoate O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "4-methoxybenzoate,hydrogen-donor:oxygen oxidoreductase (O-demethylating)" EXACT [EC:1.14.99.15] synonym: "p-anisic O-demethylase activity" EXACT [EC:1.14.99.15] synonym: "piperonylate-4-O-demethylase activity" EXACT [EC:1.14.99.15] xref: EC:1.14.99.15 xref: KEGG:R01306 xref: MetaCyc:1.14.99.15-RXN xref: RHEA:18613 xref: UM-BBD_reactionID:r0154 is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0018693 name: ethylbenzene hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: A + ethylbenzene + H(2)O = (S)-1-phenylethanol + AH(2)." [EC:1.17.99.2, RHEA:17897] synonym: "ethylbenzene dehydrogenase activity" EXACT [EC:1.17.99.2] synonym: "ethylbenzene:(acceptor) oxidoreductase activity" EXACT [EC:1.17.99.2] xref: EC:1.17.99.2 xref: KEGG:R05745 xref: MetaCyc:RXN-1301 xref: RHEA:17897 xref: UM-BBD_reactionID:r0234 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018694 name: p-cymene methyl hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: p-cymene + NADH + O2 = NAD+ + OH- + p-cumic alcohol." [UM-BBD_reactionID:r0392] xref: EC:1.17.99 xref: MetaCyc:RXN-661 xref: UM-BBD_reactionID:r0392 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018695 name: 4-cresol dehydrogenase (hydroxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 4-cresol + acceptor + H2O = 4-hydroxybenzaldehyde + reduced acceptor." [EC:1.17.99.1] synonym: "4-cresol dehydrogenase activity" EXACT [] synonym: "4-cresol:acceptor oxidoreductase (methyl-hydroxylating)" EXACT [EC:1.17.99.1] synonym: "p-cresol methylhydroxylase activity" EXACT [EC:1.17.99.1] synonym: "p-cresol-(acceptor) oxidoreductase (hydroxylating) activity" EXACT [EC:1.17.99.1] xref: EC:1.17.99.1 xref: MetaCyc:1.17.99.1-RXN xref: RHEA:15141 xref: UM-BBD_reactionID:r0272 is_a: GO:0016725 ! oxidoreductase activity, acting on CH or CH2 groups [Term] id: GO:0018697 name: carbonyl sulfide nitrogenase activity namespace: molecular_function def: "Catalysis of the reaction: carbonyl sulfide + 2 H+ + 2 e- = hydrogen sulfide + carbon monoxide." [UM-BBD_reactionID:r0600] synonym: "carbonyl sulphide nitrogenase activity" EXACT [] xref: EC:1.18.6.1 xref: UM-BBD_reactionID:r0600 is_a: GO:0016732 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, dinitrogen as acceptor [Term] id: GO:0018698 name: vinyl chloride reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: vinyl chloride + 2 H+ + 2 e- = HCl + ethene." [UM-BBD_reactionID:r0352] xref: EC:1.97.1 xref: MetaCyc:VCREDCHLOR-RXN xref: UM-BBD_reactionID:r0352 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018699 name: 1,1,1-trichloroethane reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloroethane + 2 H+ + 2 e- = 1,1-dichloroethane + HCl." [UM-BBD_reactionID:r1007] xref: EC:1.97.1 xref: UM-BBD_reactionID:r1007 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018700 name: 2-chloro-N-isopropylacetanilide reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-N-isopropylacetanilide + H+ + 2 e- = Cl- + N-isopropylacetanilide." [UM-BBD_reactionID:r0719] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0719 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018701 name: 2,5-dichlorohydroquinone reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: organohalide + 2 H+ + 2 e- = R-H + HCl. Reactants include chlorohydroquinone (forms hydroquinone) and 2,5-dichlorohydroquinone (forms chlorohydroquinone)." [UM-BBD_enzymeID:e0366] xref: EC:1.97.1 xref: UM-BBD_enzymeID:e0366 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018702 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene + H+ + 2 e- = Cl- + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethene is also known as DDE; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0440] synonym: "1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene dehalogenase activity" EXACT [] synonym: "DDE dehalogenase activity" EXACT [] xref: EC:1.97.1 xref: UM-BBD_reactionID:r0440 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018703 name: 2,4-dichlorophenoxyacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorophenoxyacetic acid + H+ + 2 e- = Cl- + 4-chlorophenoxyacetate." [UM-BBD_reactionID:r0280] xref: UM-BBD_reactionID:r0280 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018704 name: obsolete 5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-2-hydroxymuconic semialdehyde + H+ + 2 e- = Cl- + 2-hydroxymuconic semialdehyde." [UM-BBD_enzymeID:e0237] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "5-chloro-2-hydroxymuconic semialdehyde dehalogenase activity" EXACT [] xref: EC:1.97.1 xref: UM-BBD_enzymeID:e0237 is_obsolete: true [Term] id: GO:0018705 name: 1,2-dichloroethene reductive dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dichloroethene + 2 H+ + 2 e- = HCl + vinyl chloride." [UM-BBD_enzymeID:e0272] synonym: "1,2-dichloroethylene reductive dehalogenase activity" EXACT [] xref: UM-BBD_enzymeID:e0272 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018706 name: pyrogallol hydroxytransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2,3,5-tetrahydroxybenzene + 1,2,3-trihydroxybenzene = 1,3,5-trihydroxybenzene + 1,2,3,5-tetrahydroxybenzene." [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene-pyrogallol hydroxyltransferase (transhydroxylase)" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxyltransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:1,2,3-trihydroxybenzene hydroxytransferase activity" EXACT [EC:1.97.1.2] synonym: "1,2,3,5-tetrahydroxybenzene:pyrogallol transhydroxylase activity" EXACT [EC:1.97.1.2] synonym: "pyrogallol hydroxyltransferase activity" EXACT [] synonym: "transhydroxylase activity" RELATED [EC:1.97.1.2] xref: EC:1.97.1.2 xref: MetaCyc:1.97.1.2-RXN xref: UM-BBD_reactionID:r0006 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0018707 name: 1-phenanthrol methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-CH3 = X + 1-methoxyphenanthrene." [UM-BBD_reactionID:r0493] xref: UM-BBD_reactionID:r0493 is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0018708 name: thiol S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiol = S-adenosyl-L-homocysteine + a thioether." [EC:2.1.1.9] synonym: "S-adenosyl-L-methionine:thiol S-methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "thiol methyltransferase activity" EXACT [EC:2.1.1.9] synonym: "TMT" RELATED [EC:2.1.1.9] xref: EC:2.1.1.9 xref: MetaCyc:THIOL-S-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-175976 "TMT transfers CH3 from AdoMet to BME" xref: UM-BBD_enzymeID:e0146 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0018710 name: acetone carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: acetone + ATP + CO(2) + 2 H(2)O = acetoacetate + AMP + 4 H(+) + 2 phosphate." [EC:6.4.1.6, RHEA:18385] synonym: "acetone:carbon-dioxide ligase (AMP-forming)" EXACT [EC:6.4.1.6] xref: EC:6.4.1.6 xref: KEGG:R05735 xref: MetaCyc:6.4.1.6-RXN xref: RHEA:18385 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018711 name: benzoyl acetate-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: benzoyl acetyl-CoA + CoA = acetyl-CoA + benzoyl-CoA." [UM-BBD_reactionID:r0243] xref: MetaCyc:RXN-1305 xref: UM-BBD_reactionID:r0243 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018712 name: 3-hydroxybutyryl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-5-oxohexanoyl-CoA + CoASH = 3-hydroxybutyryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0010] xref: MetaCyc:R7-RXN xref: UM-BBD_reactionID:r0010 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018713 name: 3-ketopimelyl-CoA thiolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-ketopimeloyl-CoA + CoA = glutaryl-CoA + acetyl-CoA." [UM-BBD_reactionID:r0197] xref: MetaCyc:RXN-8032 xref: UM-BBD_reactionID:r0197 is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0018715 name: 9-phenanthrol UDP-glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + UDP-glucuronate = 9-phenanthryl-beta-D-glucuronide + UDP." [UM-BBD_reactionID:r0567] xref: EC:2.4.1 xref: UM-BBD_reactionID:r0567 is_a: GO:0015020 ! glucuronosyltransferase activity [Term] id: GO:0018716 name: 1-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + glucose = 1-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0525] xref: UM-BBD_reactionID:r0525 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018717 name: 9-phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + glucose = 9-phenanthryl-beta-D-glucopyranoside + H2O." [UM-BBD_reactionID:r0511] xref: UM-BBD_reactionID:r0511 is_a: GO:0019112 ! phenanthrol glycosyltransferase activity [Term] id: GO:0018718 name: 1,2-dihydroxy-phenanthrene glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1,2-dihydroxyphenanthrene + UDP-glucose = 2-hydroxy-1-phenanthryl-beta-D-glucopyranoside + UDP." [UM-BBD_reactionID:r0569] xref: EC:2.4.1 xref: UM-BBD_reactionID:r0569 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0018719 name: 6-aminohexanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 6-aminohexanoate + alpha-ketoglutarate = glutamate + 6-oxohexanoate." [UM-BBD_reactionID:r0449] xref: MetaCyc:R562-RXN xref: UM-BBD_reactionID:r0449 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0018720 name: phenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phenol + X-HPO3- = XH + phenylphosphate." [UM-BBD_reactionID:r0155] xref: MetaCyc:PHENOLPHOS-RXN xref: UM-BBD_reactionID:r0155 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0018721 name: trans-9R,10R-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-9R,10R-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-9,10-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0559] synonym: "trans-9R,10R-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0559 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018722 name: 1-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phenanthrol + X-SO3(-) = HX + 1-phenanthrylsulfate." [UM-BBD_reactionID:r0565] synonym: "1-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0565 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018723 name: 3-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenanthrol + X-SO3(-) = HX + 3-phenanthrylsulfate." [UM-BBD_reactionID:r0561] synonym: "3-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0561 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018724 name: 4-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 4-phenanthrol + X-SO3(-) = HX + 4-phenanthrylsulfate." [UM-BBD_reactionID:r0562] synonym: "4-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0562 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018725 name: trans-3,4-dihydrodiolphenanthrene sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3,4-dihydrodiolphenanthrene + 2 X-SO3(-) = 2 HX + phenanthrene-3,4-dihydrodiolsulfate conjugate." [UM-BBD_reactionID:r0558] synonym: "trans-3,4-dihydrodiolphenanthrene sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0558 is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0018726 name: 9-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 9-phenanthrol + X-SO3(-) = HX + 9-phenanthrylsulfate." [UM-BBD_reactionID:r0564] synonym: "9-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0564 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018727 name: 2-phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phenanthrol + X-SO3(-) = HX + 2-phenanthrylsulfate." [UM-BBD_reactionID:r0563] synonym: "2-phenanthrol sulphotransferase activity" EXACT [] xref: UM-BBD_reactionID:r0563 is_a: GO:0019111 ! phenanthrol sulfotransferase activity [Term] id: GO:0018729 name: propionate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + propanoate = acetate + propanoyl-CoA." [EC:2.8.3.1] synonym: "acetyl-CoA:propanoate CoA-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate coenzyme A-transferase activity" EXACT [EC:2.8.3.1] synonym: "propionate-CoA:lactoyl-CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.1] synonym: "propionyl-CoA transferase activity" EXACT [EC:2.8.3.1] xref: EC:2.8.3.1 xref: MetaCyc:PROPIONATE-COA-TRANSFERASE-RXN xref: RHEA:23520 xref: UM-BBD_reactionID:r0087 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018730 name: glutaconate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (E)-glutaconate = acetate + glutaconyl-1-CoA." [EC:2.8.3.12] synonym: "acetyl-CoA:(E)-glutaconate CoA-transferase activity" EXACT [EC:2.8.3.12] xref: EC:2.8.3.12 xref: MetaCyc:GLUTACONATE-COA-TRANSFERASE-RXN xref: RHEA:23208 xref: UM-BBD_reactionID:r0085 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0018731 name: 1-oxa-2-oxocycloheptane lactonase activity namespace: molecular_function def: "Catalysis of the reaction: 1-oxa-2-oxocycloheptane + H2O = 6-hydroxyhexanoate." [UM-BBD_reactionID:r0167] xref: UM-BBD_reactionID:r0167 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018732 name: sulfolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-sulfolactone + OH- = HSO3(-) + maleylacetate." [UM-BBD_reactionID:r0583] synonym: "sulpholactone hydrolase activity" EXACT [] xref: EC:3.1.1.92 xref: UM-BBD_reactionID:r0583 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018733 name: 3,4-dihydrocoumarin hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydrocoumarin + H2O = 3-(2-hydroxyphenyl) propionate." [UM-BBD_reactionID:r0419] xref: EC:3.1.1.35 xref: UM-BBD_reactionID:r0419 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018734 name: butyrolactone hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: butyrolactone + H2O = 4-hydroxybutanoate." [UM-BBD_reactionID:r0016] xref: UM-BBD_reactionID:r0016 is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0018736 name: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxycyclohexane-1-carboxyl-CoA + H2O = 3-hydroxypimeloyl-CoA." [UM-BBD_reactionID:r0206] xref: UM-BBD_reactionID:r0206 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018737 name: 2-ketocyclohexane-1-carboxyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-ketocyclohexane-1-carboxyl-CoA + H2O = pimeloyl-CoA." [UM-BBD_reactionID:r0193] xref: UM-BBD_reactionID:r0193 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018738 name: S-formylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: S-formylglutathione + H(2)O = formate + glutathione + H(+)." [EC:3.1.2.12, RHEA:14961] subset: goslim_chembl xref: EC:3.1.2.12 xref: KEGG:R00527 xref: MetaCyc:S-FORMYLGLUTATHIONE-HYDROLASE-RXN xref: reactome:R-HSA-5693724 "ESD dimer hydrolyses S-FGSH to GSH" xref: RHEA:14961 xref: UM-BBD_reactionID:r0241 is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0018739 name: 4-hydroxybenzoyl-CoA thioesterase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoyl-CoA + H(2)O = 4-hydroxybenzoate + CoA + H(+)." [EC:3.1.2.23, RHEA:11948] synonym: "4-hydroxybenzoyl-CoA hydrolase activity" EXACT [EC:3.1.2.23] synonym: "4-hydroxybenzoyl-CoA thiolesterase activity" EXACT [] xref: EC:3.1.2.23 xref: KEGG:R01301 xref: MetaCyc:3.1.2.23-RXN xref: RHEA:11948 xref: UM-BBD_reactionID:r0141 is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0018740 name: 2'-hydroxybiphenyl-2-sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-hydroxybiphenyl-2-sulfinate + H(2)O = biphenyl-2-ol + sulfite." [EC:3.13.1.3, RHEA:12945] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfinolyase activity" EXACT [] synonym: "2'-hydroxybiphenyl-2-sulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2'-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate sulfohydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl) benzenesulfinate:H2O hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate desulfinase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulfinate hydrolase activity" EXACT [EC:3.13.1.3] synonym: "2-(2-hydroxyphenyl)benzenesulphinate hydrolase activity" EXACT [] synonym: "dibenzothiophene desulfurization enzyme B" RELATED [EC:3.13.1.3] synonym: "DszB" RELATED [EC:3.13.1.3] synonym: "gene dszB-encoded hydrolase activity" EXACT [EC:3.13.1.3] synonym: "HBPSi desulfinase activity" EXACT [EC:3.13.1.3] synonym: "HPBS desulfinase activity" EXACT [EC:3.13.1.3] xref: EC:3.13.1.3 xref: KEGG:R07311 xref: MetaCyc:RXN-624 xref: RHEA:12945 xref: UM-BBD_enzymeID:e0216 is_a: GO:0046508 ! hydrolase activity, acting on carbon-sulfur bonds [Term] id: GO:0018741 name: alkyl sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: dodecyl sulfate + H2O = sulfate + H+ + 1-dodecanol." [UM-BBD_reactionID:r0602] synonym: "alkyl sulphatase activity" EXACT [] xref: EC:3.1.6 xref: UM-BBD_reactionID:r0602 is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0018742 name: epoxide hydrolase B activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro- or hydroxyepoxypropane to produce chloropropane diol or glycerol. Acts on R enantiomers." [UM-BBD_enzymeID:e0051] xref: EC:3.3.2 xref: UM-BBD_enzymeID:e0051 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018743 name: phenanthrene-9,10-epoxide hydrolase (9R,10R-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9R,10R-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0560] xref: EC:3.3.2 xref: UM-BBD_reactionID:r0560 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018744 name: limonene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: limonene-1,2-epoxide + H2O = limonene-1,2-diol. Other substrates include alicyclic and 1-methyl-substituted epoxides, such as 1-methylcyclohexene oxide, indene oxide and cyclohexene oxide." [EC:3.3.2.8] synonym: "limonene oxide hydrolase activity" EXACT [EC:3.3.2.8] xref: EC:3.3.2.8 xref: MetaCyc:3.3.2.8-RXN xref: RHEA:10700 xref: UM-BBD_reactionID:r0734 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018745 name: epoxide hydrolase A activity namespace: molecular_function def: "Catalysis of the hydrolysis of the ether in chloro-, bromo- or hydroxyepoxypropane to produce a chloro- or bromopropane diol or glycerol." [UM-BBD_enzymeID:e0049] xref: EC:3.3.2 xref: UM-BBD_enzymeID:e0049 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0018746 name: phenanthrene-3,4-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-3,4-oxide + H2O = trans-3,4-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0535] xref: UM-BBD_reactionID:r0535 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018747 name: phenanthrene-1,2-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-1,2-oxide + H2O = trans-1,2-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0536] xref: UM-BBD_reactionID:r0536 is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0018748 name: iprodione amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: iprodione + OH- = 3,5-dichlorophenylcarboximide + N-isopropylcarbamate." [UM-BBD_reactionID:r0706] xref: UM-BBD_reactionID:r0706 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018749 name: (3,5-dichlorophenylurea)acetate amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (3,5-dichlorophenylurea)acetate + OH- = 3,5-dichloroaniline + N-carboxyglycine." [UM-BBD_reactionID:r0708] xref: UM-BBD_reactionID:r0708 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018750 name: biuret amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: biuret + H2O = urea + CO2 + NH3." [EC:3.5.1.84] xref: EC:3.5.1.84 xref: RHEA:17525 xref: UM-BBD_reactionID:r0846 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0018751 name: 3,5-dichlorophenylcarboximide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dichlorophenylcarboximide + OH- = (3,5-dichlorophenylurea)acetate." [UM-BBD_reactionID:r0707] xref: EC:3.5.2 xref: UM-BBD_reactionID:r0707 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018752 name: epsilon-caprolactam lactamase activity namespace: molecular_function def: "Catalysis of the reaction: epsilon-caprolactam + H2O = H+ + 6-aminohexanoate." [UM-BBD_reactionID:r0448] xref: MetaCyc:R561-RXN xref: UM-BBD_reactionID:r0448 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018753 name: cyanuric acid amidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyanuric acid + H2O = biuret + CO2." [EC:3.5.2.15] xref: EC:3.5.2.15 xref: MetaCyc:R468-RXN xref: RHEA:14641 xref: UM-BBD_reactionID:r0116 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0018754 name: ammelide aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammelide + H2O = cyanuric acid + NH3." [PMID:1991731] xref: MetaCyc:RXN-8017 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018755 name: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + OH- = 2,4-dihydroxy-6-amino-1,3,5-triazine + Cl-." [UM-BBD_reactionID:r1414] is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018756 name: ammeline aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: ammeline + H2O = ammelide + NH3." [PMID:1991731] xref: MetaCyc:RXN-8016 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018757 name: deisopropylhydroxyatrazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropylhydroxyatrazine + H2O = NH3 + 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine." [UM-BBD_reactionID:r0121] xref: KEGG:R05574 xref: UM-BBD_reactionID:r0121 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018758 name: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine aminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-6-(N'-ethyl)amino-1,3,5-triazine + H2O = CH3CH2NH2 + cyanuric acid." [UM-BBD_reactionID:r0122] xref: UM-BBD_reactionID:r0122 is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0018759 name: methenyltetrahydromethanopterin cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2)O = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + H(+)." [EC:3.5.4.27, RHEA:19053] synonym: "5,10-methenyltetrahydromethanopterin 10-hydrolase (decyclizing)" EXACT [EC:3.5.4.27] synonym: "5,10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H(4)MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "methenyl-H4MPT cyclohydrolase activity" EXACT [EC:3.5.4.27] synonym: "N5,N10-methenyltetrahydromethanopterin cyclohydrolase activity" EXACT [EC:3.5.4.27] xref: EC:3.5.4.27 xref: KEGG:R03464 xref: MetaCyc:3.5.4.27-RXN xref: RHEA:19053 xref: UM-BBD_reactionID:r0347 is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0018760 name: thiocyanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + 2 H(+) + thiocyanate = carbonyl sulfide + NH(4)(+)." [EC:3.5.5.8, RHEA:21464] synonym: "thiocyanate aminohydrolase activity" EXACT [EC:3.5.5.8] xref: EC:3.5.5.8 xref: KEGG:R05780 xref: MetaCyc:RXN-1761 xref: RHEA:21464 xref: UM-BBD_reactionID:r0598 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0018761 name: bromoxynil nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzonitrile + 2 H(2)O = 3,5-dibromo-4-hydroxybenzoate + NH(4)(+). Involved in the bacterial degradation of the herbicide bromoxynil." [EC:3.5.5.6, RHEA:22100] synonym: "3,5-dibromo-4-hydroxybenzonitrile aminohydrolase activity" EXACT [] synonym: "bromoxynil-specific nitrilase activity" EXACT [] xref: EC:3.5.5.6 xref: KEGG:R04349 xref: MetaCyc:3.5.5.6-RXN xref: RHEA:22100 xref: UM-BBD_enzymeID:e0357 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018762 name: aliphatic nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: R-CN + H2O = R-COOH + NH3." [EC:3.5.5.7] synonym: "aliphatic nitrile aminohydrolase activity" EXACT [EC:3.5.5.7] xref: EC:3.5.5.7 xref: MetaCyc:3.5.5.7-RXN xref: UM-BBD_reactionID:r0622 is_a: GO:0000257 ! nitrilase activity [Term] id: GO:0018763 name: hydroxydechloroatrazine ethylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + H2O = N-isopropylammelide + ethylamine." [EC:3.5.99.3] synonym: "4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine ethylaminohydrolase activity" EXACT [EC:3.5.99.3] synonym: "AtzB" RELATED [EC:3.5.99.3] synonym: "hydroxyatrazine ethylaminohydrolase activity" EXACT [] synonym: "hydroxyatrazine hydrolase activity" EXACT [EC:3.5.99.3] xref: EC:3.5.99.3 xref: MetaCyc:R122-RXN xref: RHEA:23092 xref: UM-BBD_enzymeID:e0085 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018764 name: N-isopropylammelide isopropylaminohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-isopropylammelide + H2O = cyanuric acid + isopropylamine." [EC:3.5.99.4] synonym: "AtzC" RELATED [EC:3.5.99.4] xref: EC:3.5.99.4 xref: MetaCyc:R123-RXN xref: RHEA:23608 xref: UM-BBD_enzymeID:e0086 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0018765 name: 2-hydroxy-6-oxohepta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cis,cis-2-hydroxy-6-oxohept-2,4-dienoate + OH- = cis-2-hydroxypenta-2,4-dienoate + acetate." [UM-BBD_reactionID:r0263] xref: MetaCyc:2-OH-6-OXOHEPTA-2-4-DIENOATE-HYDR-RXN xref: UM-BBD_reactionID:r0263 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018766 name: dihydrophloroglucinol hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrophloroglucinol + OH- = 3-hydroxy-5-oxohexanoate." [UM-BBD_reactionID:r0008] xref: KEGG:R07831 xref: MetaCyc:R6-RXN xref: UM-BBD_reactionID:r0008 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018767 name: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate + H2O = cis-2-hydroxypenta-2,4-dienoate + isobutyrate." [UM-BBD_reactionID:r0399] xref: UM-BBD_reactionID:r0399 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018768 name: 2-hydroxy-6-oxo-6-(2'-aminophenyl)hexa-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxo-(2'-aminophenyl)-hexa-2,4-dienoate + H2O = 2-aminobenzoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0458] xref: EC:3.7.1.13 xref: UM-BBD_reactionID:r0458 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018769 name: 2-hydroxy-6-oxoocta-2,4-dienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-6-oxoocta-2,4-dienoate + H2O = H+ + propanoate + cis-2-hydroxypenta-2,4-dienoate." [UM-BBD_reactionID:r0311] xref: UM-BBD_reactionID:r0311 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018770 name: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2E,4E,7-trienoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 6-oxo-2-hydroxy-7-(4'-chlorophenyl)-3,8,8-trichloroocta-2Z,4Z,7-trienoate + H2O = 2-(4'-chlorophenyl)-3,3-dichloropropenoate + cis-2-Hydroxy-3-chloropenta-2,4-dienone + H+." [UM-BBD_reactionID:r0444] xref: UM-BBD_reactionID:r0444 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018771 name: 2-hydroxy-6-oxonona-2,4-dienedioate hydrolase activity namespace: molecular_function alt_id: GO:0008680 def: "Catalysis of the reaction: (2E,4Z)-2-hydroxy-6-oxonona-2,4-dienedioate + H2O = (2E)-2-hydroxypenta-2,4-dienoate + H+ + succinate." [RHEA:24789] synonym: "(2E,4Z)-2-hydroxy-6-oxona-2,4-dienedioate succinylhydrolase activity" EXACT systematic_synonym [EC:3.7.1.14] synonym: "2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase activity" EXACT [UM-BBD_reactionID:r0438] xref: EC:3.7.1.14 xref: MetaCyc:MHPCHYDROL-RXN xref: RHEA:24789 xref: UM-BBD_reactionID:r0438 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018772 name: trioxoheptanoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4,6-trioxoheptanoate + H2O = acetylpyruvate + acetate." [MetaCyc:R306-RXN, UM-BBD_reactionID:r0094] xref: MetaCyc:R306-RXN xref: UM-BBD_reactionID:r0094 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018773 name: acetylpyruvate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetylpyruvate + H(2)O = acetate + H(+) + pyruvate." [EC:3.7.1.6, RHEA:16097] synonym: "2,4-dioxopentanoate acetylhydrolase activity" EXACT [EC:3.7.1.6] xref: EC:3.7.1.6 xref: KEGG:R00324 xref: MetaCyc:ACETYLPYRUVATE-HYDROLASE-RXN xref: RHEA:16097 xref: UM-BBD_reactionID:r0095 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018774 name: 2,6-dioxo-6-phenylhexa-3-enoate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,6-dioxo-6-phenylhexa-3-enoate + H2O = benzoate + 2-oxopent-4-enoate." [EC:3.7.1.8] synonym: "2,6-dioxo-6-phenylhexa-3-enoate benzoylhydrolase activity" EXACT [EC:3.7.1.8] synonym: "2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase activity" EXACT [] synonym: "HOHPDA hydrolase activity" EXACT [EC:3.7.1.8] xref: EC:3.7.1.8 xref: MetaCyc:3.7.1.8-RXN xref: RHEA:17161 xref: UM-BBD_enzymeID:e0033 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018775 name: 2-hydroxymuconate-semialdehyde hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxymuconate semialdehyde + H2O = formate + 2-oxopent-4-enoate." [EC:3.7.1.9] synonym: "2-hydroxymuconate-semialdehyde formylhydrolase activity" EXACT [EC:3.7.1.9] synonym: "2-hydroxymuconic semialdehyde hydrolase activity" EXACT [EC:3.7.1.9] synonym: "HMSH" RELATED [EC:3.7.1.9] synonym: "HOD hydrolase activity" EXACT [EC:3.7.1.9] xref: EC:3.7.1.9 xref: MetaCyc:3.7.1.9-RXN xref: RHEA:14549 xref: UM-BBD_enzymeID:e0139 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0018776 name: trans-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trans-3-chloroacrylic acid + H2O = H+ + malonate semialdehyde." [UM-BBD_reactionID:r0689] xref: UM-BBD_reactionID:r0689 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018777 name: 1,3,4,6-tetrachloro-1,4-cyclohexadiene halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: alkyl halide + H2O = alcohol + HCl. Substrates are 1,3(R),4,6(R)-tetrachloro-1,4-cyclohexadiene (forms 2,4,5-trichloro-2,5-cyclohexadiene-1-ol) and 2,4,5-trichloro-2,5-cyclohexadiene-1-ol (forms 2,5-dichloro-2,5-cyclohexadiene-1,4-diol)." [PMID:10464214] is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018778 name: DL-2 haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: trichloroacetate + 2 H2O = 3 H+ + 3 Cl- + oxalate." [UM-BBD_reactionID:r0382] xref: EC:3.8.1.10 xref: MetaCyc:RXN-9150 xref: UM-BBD_reactionID:r0382 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018779 name: obsolete 2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it was derived from a UM-BBD enzyme entry that has been deleted, and no other information can be found to suggest that it is a naturally occurring activity. synonym: "2-chloro-4,6-dihydroxy-1,3,5-triazine hydrolase activity" EXACT [] xref: EC:3.8.1 xref: UM-BBD_enzymeID:e0100 is_obsolete: true [Term] id: GO:0018780 name: dichloroacetate halidohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dichloroacetate + H2O = 2 HCl + glyoxylate." [UM-BBD_reactionID:r0383] xref: UM-BBD_reactionID:r0383 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018781 name: S-triazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-halo or 1-pseudohalo-S-triazine = 1-hydroxy-S-triazine." [UM-BBD_ruleID:bt0330] xref: UM-BBD_enzymeID:e0091 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018782 name: cis-chloroacrylic acid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: cis-3-chloroacrylic acid + H2O = H+ + HCl + malonate semialdehyde." [UM-BBD_reactionID:r0688] xref: UM-BBD_reactionID:r0688 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018783 name: deisopropyldeethylatrazine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deisopropyldeethylatrazine + H2O = 2-chloro-4-hydroxy-6-amino-1,3,5-triazine + NH3." [UM-BBD_reactionID:0129] is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018784 name: (S)-2-haloacid dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-haloacid + H2O = (R)-2-hydroxyacid + halide." [EC:3.8.1.2] synonym: "(S)-2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloacid dehalogenase activity" EXACT [] synonym: "2-haloacid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoic acid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "2-haloalkanoid acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "2-halocarboxylic acid dehalogenase II activity" EXACT [EC:3.8.1.2] synonym: "DL-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "halocarboxylic acid halidohydrolase activity" EXACT [EC:3.8.1.2] synonym: "L-2-haloacid dehalogenase activity" EXACT [EC:3.8.1.2] synonym: "L-DEX activity" EXACT [EC:3.8.1.2] xref: EC:3.8.1.2 xref: MetaCyc:2-HALOACID-DEHALOGENASE-RXN xref: UM-BBD_reactionID:r0090 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018785 name: haloacetate dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: haloacetate + H2O = glycolate + halide." [EC:3.8.1.3] synonym: "haloacetate halidohydrolase activity" EXACT [EC:3.8.1.3] synonym: "monohaloacetate dehalogenase activity" EXACT [EC:3.8.1.3] xref: EC:3.8.1.3 xref: MetaCyc:HALOACETATE-DEHALOGENASE-RXN xref: UM-BBD_enzymeID:e0006 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018786 name: haloalkane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-haloalkane + H2O = a primary alcohol + halide." [EC:3.8.1.5] synonym: "1-chlorohexane halidohydrolase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane dehalogenase activity" EXACT [EC:3.8.1.5] synonym: "1-haloalkane halidohydrolase activity" EXACT [EC:3.8.1.5] xref: EC:3.8.1.5 xref: MetaCyc:HALOALKANE-DEHALOGENASE-RXN xref: RHEA:25185 xref: UM-BBD_enzymeID:e0003 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018787 name: 4-chlorobenzoyl-CoA dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoyl-CoA + H2O = 4-hydroxybenzoyl CoA + chloride." [EC:3.8.1.7] synonym: "4-chlorobenzoyl CoA chlorohydrolase activity" EXACT [EC:3.8.1.7] xref: EC:3.8.1.7 xref: MetaCyc:3.8.1.7-RXN xref: RHEA:14853 xref: UM-BBD_enzymeID:e0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018788 name: atrazine chlorohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: atrazine + H(2)O = 4-(ethylamino)-2-hydroxy-6-(isopropylamino)-1,3,5-triazine + chloride + H(+)." [EC:3.8.1.8, RHEA:11312] synonym: "AtzA" RELATED [EC:3.8.1.8] xref: EC:3.8.1.8 xref: KEGG:R05558 xref: MetaCyc:3.8.1.8-RXN xref: RHEA:11312 xref: UM-BBD_reactionID:r0113 is_a: GO:0019120 ! hydrolase activity, acting on acid halide bonds, in C-halide compounds [Term] id: GO:0018789 name: cyclamate sulfohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexylsulfamate + H(2)O = cyclohexylamine + sulfate." [EC:3.10.1.2, RHEA:18481] synonym: "cyclamate sulfamatase activity" EXACT [] synonym: "cyclamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclamate sulphohydrolase activity" EXACT [] synonym: "cyclohexylsulfamate sulfamidase activity" EXACT [EC:3.10.1.2] synonym: "cyclohexylsulfamate sulfohydrolase activity" EXACT [EC:3.10.1.2] xref: EC:3.10.1.2 xref: KEGG:R02564 xref: MetaCyc:CYCLAMATE-SULFOHYDROLASE-RXN xref: RHEA:18481 xref: UM-BBD_reactionID:r0755 is_a: GO:0016826 ! hydrolase activity, acting on acid sulfur-nitrogen bonds [Term] id: GO:0018791 name: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-3-carboxy-6-oxo-7-methylocta-2,4-dienoate = CO2 + 2-hydroxy-6-oxo-7-methylocta-2,4-dienoate." [UM-BBD_reactionID:r0398] xref: UM-BBD_reactionID:r0398 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018792 name: bis(4-chlorophenyl)acetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: bis(4-chlorophenyl)acetate + H+ = CO2 + bis(4-chlorophenyl)methane. Bis(4-chlorophenyl)acetate is also known as DDA; bis(4-chlorophenyl)methane is also known as DDM." [UM-BBD_reactionID:r0520] synonym: "DDA decarboxylase activity" EXACT [] xref: UM-BBD_reactionID:r0520 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018793 name: 3,5-dibromo-4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5-dibromo-4-hydroxybenzoate + H+ = CO2 + 2,6-dibromophenol." [UM-BBD_reactionID:r0546] xref: UM-BBD_reactionID:r0546 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018794 name: 2-hydroxyisobutyrate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate + H+ = CO2 + 2-propanol." [UM-BBD_reactionID:r0617] xref: UM-BBD_reactionID:r0617 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018795 name: 2-hydroxy-2-methyl-1,3-dicarbonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2-methyl-1,3-dicarbonate + H+ = CO2 + L-lactate." [UM-BBD_reactionID:r0621] xref: UM-BBD_reactionID:r0621 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018796 name: 4,5-dihydroxyphthalate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4,5-dihydroxyphthalate = 3,4-dihydroxybenzoate + CO2." [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase (3,4-dihydroxybenzoate-forming)" EXACT [EC:4.1.1.55] synonym: "4,5-dihydroxyphthalate carboxy-lyase activity" EXACT [EC:4.1.1.55] xref: EC:4.1.1.55 xref: MetaCyc:45-DIHYDROXYPHTHALATE-DECARBOXYLASE-RXN xref: RHEA:24184 xref: UM-BBD_enzymeID:e0106 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018798 name: gallate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: gallate + H(+) = CO(2) + pyrogallol." [EC:4.1.1.59, RHEA:12749] synonym: "gallate carboxy-lyase (pyrogallol-forming)" EXACT [EC:4.1.1.59] synonym: "gallate carboxy-lyase activity" EXACT [EC:4.1.1.59] synonym: "gallic acid decarboxylase activity" EXACT [] xref: EC:4.1.1.59 xref: KEGG:R03247 xref: MetaCyc:GALLATE-DECARBOXYLASE-RXN xref: RHEA:12749 xref: UM-BBD_reactionID:r0005 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018799 name: 4-hydroxybenzoate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxybenzoate + H(+) = CO(2) + phenol." [EC:4.1.1.61, RHEA:10876] synonym: "4-hydroxybenzoate carboxy-lyase (phenol-forming)" EXACT [EC:4.1.1.61] synonym: "4-hydroxybenzoate carboxy-lyase activity" EXACT [EC:4.1.1.61] synonym: "p-hydroxybenzoate decarboxylase activity" EXACT [EC:4.1.1.61] xref: EC:4.1.1.61 xref: KEGG:R01238 xref: MetaCyc:4-HYDROXYBENZOATE-DECARBOXYLASE-RXN xref: RHEA:10876 xref: UM-BBD_reactionID:r0159 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018800 name: 5-oxopent-3-ene-1,2,5-tricarboxylate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2." [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,6-dioate decarboxylase activity" EXACT [EC:4.1.1.68] synonym: "5-carboxymethyl-2-oxo-hex-3-ene-1,7-dioate decarboxylase activity" EXACT [] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase (2-oxohept-3-enedioate-forming)" EXACT [EC:4.1.1.68] synonym: "5-oxopent-3-ene-1,2,5-tricarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.68] synonym: "HpaG-2" RELATED [] synonym: "HpaG2" RELATED [] synonym: "OPET decarboxylase activity" EXACT [] xref: EC:4.1.1.68 xref: MetaCyc:4.1.1.68-RXN xref: RHEA:14397 xref: UM-BBD_reactionID:r0367 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018801 name: glutaconyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: trans-glutaconyl-CoA + H(+) = but-2-enoyl-CoA + CO(2)." [EC:4.1.1.70, RHEA:23972] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase (but-2-enoyl-CoA-forming)" EXACT [EC:4.1.1.70] synonym: "4-carboxybut-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] synonym: "glutaconyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.70] synonym: "pent-2-enoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.70] xref: EC:4.1.1.70 xref: KEGG:R03028 xref: MetaCyc:GLUTACONYL-COA-DECARBOXYLASE-RXN xref: RHEA:23972 xref: UM-BBD_reactionID:r0199 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018802 name: 2,4-dihydroxyhept-2-ene-1,7-dioate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate = pyruvate + succinic semialdehyde." [UM-BBD_reactionID:r0370] xref: EC:4.1.2 xref: UM-BBD_reactionID:r0370 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018803 name: 4-(2-carboxyphenyl)-2-oxobut-3-enoate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: (3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate = 2-carboxybenzaldehyde + pyruvate." [EC:4.1.2.34] synonym: "(3E)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.34] synonym: "(3Z)-4-(2-carboxyphenyl)-2-oxobut-3-enoate 2-carboxybenzaldehyde-lyase activity" NARROW [EC:4.1.2.34] synonym: "2'-carboxybenzalpyruvate aldolase activity" EXACT [EC:4.1.2.34] synonym: "trans-2'-carboxybenzalpyruvate hydratase-aldolase activity" EXACT [] xref: EC:4.1.2.34 xref: MetaCyc:4.1.2.34-RXN xref: RHEA:16453 xref: UM-BBD_reactionID:r0487 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0018805 name: benzylsuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: fumarate + toluene = 2-benzylsuccinate." [EC:4.1.99.11, RHEA:10416] synonym: "benzylsuccinate fumarate-lyase (toluene-forming)" EXACT [EC:4.1.99.11] synonym: "benzylsuccinate fumarate-lyase activity" EXACT [EC:4.1.99.11] xref: EC:4.1.99.11 xref: KEGG:R05598 xref: MetaCyc:RXN-863 xref: RHEA:10416 xref: UM-BBD_enzymeID:e0259 is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0018807 name: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxycyclohex-1-ene-1-carboxyl-CoA + H2O = 2,6-dihydroxycyclohexane-1-carboxyl-CoA." [UM-BBD_reactionID:r0204] xref: EC:3.7.1.21 xref: RHEA:39651 xref: UM-BBD_reactionID:r0204 is_a: GO:0016822 ! hydrolase activity, acting on acid carbon-carbon bonds [Term] id: GO:0018808 name: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate + H2O = pyruvate + 1-hydroxy-2-naphthaldehyde." [UM-BBD_reactionID:r0484] xref: UM-BBD_reactionID:r0484 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018809 name: E-phenylitaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: E-phenylitaconyl-CoA + H2O = (hydroxymethylphenyl)succinyl-CoA." [UM-BBD_reactionID:r0331] xref: UM-BBD_reactionID:r0331 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018810 name: trans-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate + H2O = pyruvate + 3-hydroxy-2-formylbenzothiophene." [UM-BBD_reactionID:r0164] xref: UM-BBD_reactionID:r0164 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018811 name: cyclohex-1-ene-1-carboxyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohex-1-ene-1-carboxyl-CoA + H2O = 2-hydroxycyclohexane-1-carboxyl-CoA." [MetaCyc:R266-RXN, UM-BBD_reactionID:r0191] xref: MetaCyc:R266-RXN xref: UM-BBD_reactionID:r0191 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018812 name: 3-hydroxyacyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: alkene-CoA + H2O = alcohol-CoA. Substrates are crotonoyl-CoA (producing 3-hydroxyacyl-CoA) and 2,3-didehydro-pimeloyl-CoA (producing 3-hydroxypimeloyl-CoA)." [UM-BBD_ruleID:bt0291] xref: reactome:R-HSA-8957389 "RPP14 (HTD2) dehydrates 3HA-CoA to t2E-CoA" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018813 name: trans-o-hydroxybenzylidenepyruvate hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-3-enoate-4-benzenoid + H2O = pyruvate + benzaldehyde derivative. Substrates are (3E)-4-(5-amino-2-hydroxy-phenyl)-2-oxo-but-3-ene-1-oic-acid (forms 5-aminosalicylaldehyde) and trans-o-hydroxybenzylidenepyruvate (forms salicylaldehyde)." [UM-BBD_enzymeID:e0257] xref: EC:4.1.2.45 xref: RHEA:27389 xref: UM-BBD_enzymeID:e0257 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018814 name: phenylacetaldoxime dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (trans)-phenylacetaldoxime = H(2)O + phenylacetonitrile." [EC:4.99.1.7, RHEA:20069] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase (phenylacetonitrile-forming) activity" EXACT [EC:4.99.1.7] synonym: "(Z)-phenylacetaldehyde-oxime hydro-lyase activity" EXACT [EC:4.99.1.7] synonym: "arylacetaldoxime dehydratase activity" EXACT [EC:4.99.1.7] synonym: "OxdB" RELATED [EC:4.99.1.7] synonym: "PAOx dehydratase activity" EXACT [EC:4.99.1.7] xref: EC:4.99.1.7 xref: KEGG:R07638 xref: MetaCyc:4.99.1.7-RXN xref: RHEA:20069 xref: UM-BBD_reactionID:r0697 is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0018815 name: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon hydratase-aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-5-hydroxy-6-(3-carboxy-3-oxopropenyl)-1H-2-pyridon + H2O = 2-oxobut-3-enanoate + 2,5,6-trihydroxy-3-methylpyridine." [MetaCyc:RXN-645, UM-BBD_reactionID:r0051] xref: MetaCyc:RXN-645 xref: UM-BBD_reactionID:r0051 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018816 name: 2-hydroxyisobutyrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxyisobutyrate = H2O + methacrylate." [UM-BBD_reactionID:r0618] xref: UM-BBD_reactionID:r0618 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018817 name: 2-oxo-hept-3-ene-1,7-dioate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate." [UM-BBD_reactionID:r0369] synonym: "2-oxo-hepta-3-ene-1,7-dioate hydratase activity" EXACT [] synonym: "2-oxo-hepta-3-ene-1,7-dioic acid hydratase activity" EXACT [] synonym: "HpaH" RELATED [] xref: MetaCyc:HYDROXYHEPTA-DIENEDIOATE-HYDROXY-RXN xref: UM-BBD_reactionID:r0369 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018818 name: acetylene hydratase activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde = acetylene + H(2)O." [EC:4.2.1.112, RHEA:17885] synonym: "acetaldehyde hydro-lyase activity" EXACT [EC:4.2.1.112] synonym: "AH" RELATED [EC:4.2.1.112] synonym: "AHy" RELATED [EC:4.2.1.112] xref: EC:4.2.1.112 xref: KEGG:R05380 xref: MetaCyc:R141-RXN xref: RHEA:17885 xref: UM-BBD_reactionID:r0591 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018819 name: lactoyl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: lactoyl-CoA = acryloyl-CoA + H2O." [EC:4.2.1.54] synonym: "acrylyl coenzyme A hydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl coenzyme A dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase (acryloyl-CoA-forming)" EXACT [EC:4.2.1.54] synonym: "lactoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.54] synonym: "lactyl CoA dehydratase activity" EXACT [EC:4.2.1.54] synonym: "lactyl-coenzyme A dehydrase activity" EXACT [EC:4.2.1.54] xref: EC:4.2.1.54 xref: MetaCyc:LACTOYL-COA-DEHYDRATASE-RXN xref: MetaCyc:RXN-781 xref: RHEA:21056 xref: UM-BBD_reactionID:r0086 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018820 name: cyanamide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: urea = cyanamide + H(2)O." [EC:4.2.1.69, RHEA:23056] synonym: "urea hydro-lyase (cyanamide-forming)" EXACT [EC:4.2.1.69] synonym: "urea hydro-lyase activity" EXACT [EC:4.2.1.69] xref: EC:4.2.1.69 xref: KEGG:R00778 xref: MetaCyc:CYANAMIDE-HYDRATASE-RXN xref: RHEA:23056 xref: UM-BBD_reactionID:r0668 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018822 name: nitrile hydratase activity namespace: molecular_function def: "Catalysis of the reaction: an aliphatic amide = a nitrile + H2O." [EC:4.2.1.84] synonym: "3-cyanopyridine hydratase activity" EXACT [EC:4.2.1.84] synonym: "acrylonitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic nitrile hydratase activity" EXACT [EC:4.2.1.84] synonym: "aliphatic-amide hydro-lyase (nitrile-forming)" EXACT [EC:4.2.1.84] synonym: "H-NHase activity" EXACT [EC:4.2.1.84] synonym: "L-NHase activity" EXACT [EC:4.2.1.84] synonym: "NHase activity" EXACT [EC:4.2.1.84] synonym: "nitrile hydro-lyase activity" EXACT [EC:4.2.1.84] xref: EC:4.2.1.84 xref: MetaCyc:NITRILE-HYDRATASE-RXN xref: RHEA:12673 xref: UM-BBD_enzymeID:e0067 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018823 name: cyclohexa-1,5-dienecarbonyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyclohexa-1,5-diene-1-carbonyl-CoA + H(2)O = 6-hydroxycyclohex-1-enecarbonyl-CoA." [EC:4.2.1.100, RHEA:21856] synonym: "6-hydroxycyclohex-1-enecarbonyl-CoA (cyclohexa-1,5-dienecarbonyl-CoA-forming)" RELATED [EC:4.2.1.100] synonym: "cyclohex-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [] synonym: "cyclohexa-1,5-diene-1-carbonyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-diene-1-carboxyl-CoA hydratase activity" EXACT [EC:4.2.1.100] synonym: "cyclohexa-1,5-dienecarbonyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.100] synonym: "dienoyl-CoA hydratase activity" EXACT [EC:4.2.1.100] xref: EC:4.2.1.100 xref: KEGG:R05597 xref: MetaCyc:4.2.1.100-RXN xref: RHEA:21856 xref: UM-BBD_reactionID:r0203 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0018824 name: (hydroxyamino)benzene mutase activity namespace: molecular_function def: "Catalysis of the reaction: (hydroxyamino)benzene = 2-aminophenol." [EC:5.4.4.1, UM-BBD_reactionID:r0304] synonym: "(hydroxyamino)benzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "HAB mutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene hydroxymutase activity" EXACT [EC:5.4.4.1] synonym: "hydroxylaminobenzene mutase activity" EXACT [EC:5.4.4.1] xref: MetaCyc:5.4.4.1-RXN xref: UM-BBD_reactionID:r0304 is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0018825 name: triethanolamine lyase activity namespace: molecular_function def: "Catalysis of the reaction: triethanolamine = diethanolamine + acetaldehyde." [UM-BBD_enzymeID:e0421] xref: UM-BBD_enzymeID:e0421 is_a: GO:0016843 ! amine-lyase activity [Term] id: GO:0018826 name: methionine gamma-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine = methanethiol + NH3 + 2-oxobutanoate." [EC:4.4.1.11] synonym: "L-methioninase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine gamma-lyase activity" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating)" EXACT [EC:4.4.1.11] synonym: "L-methionine methanethiol-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.11] synonym: "methioninase activity" EXACT [EC:4.4.1.11] synonym: "methionine dethiomethylase activity" EXACT [EC:4.4.1.11] synonym: "methionine lyase activity" EXACT [EC:4.4.1.11] xref: EC:4.4.1.11 xref: MetaCyc:METHIONINE-GAMMA-LYASE-RXN xref: RHEA:24750 xref: UM-BBD_reactionID:r0432 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0018827 name: 1-chloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1-chloro-2,2-bis(4-chlorophenyl)ethane = HCl + unsym-bis(4-chlorophenyl)ethene. 1-chloro-2,2-bis(4-chlorophenyl)ethane is also known as DDMS; unsym-bis(4-chlorophenyl)ethene is also known as DDNU." [UM-BBD_reactionID:r0515] synonym: "DDMS dehydrochlorinase activity" EXACT [] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0515 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018828 name: halohydrin hydrogen-halide-lyase A activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloro- or bromopropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0048] xref: EC:4.5.1 xref: UM-BBD_enzymeID:e0048 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018829 name: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane = HCl + 1-chloro-2,2-bis(4-chlorophenyl)ethene. 1,1-dichloro-2,2-bis(4-chlorophenyl)ethane is also known as DDD; 1-chloro-2,2-bis(4-chlorophenyl)ethene is also known as DDMU." [UM-BBD_reactionID:r0513] synonym: "DDD dehydrochlorinase activity" EXACT [] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0513 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018830 name: gamma-hexachlorocyclohexane dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-hexachlorocyclohexane + HCl = 1,3(R),4(S),5(S),6(R)-pentachlorocyclohexene." [UM-BBD_enzymeID:e0359] xref: EC:4.5.1 xref: UM-BBD_enzymeID:e0359 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018831 name: 5-chloro-1,2,4-trihydroxybenzene dechlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 5-chloro-1,2,4-trihydroxybenzene = Cl- + H+ + 2-hydroxy-1,4-benzoquinone." [UM-BBD_reactionID:r0666] xref: EC:4.5.1 xref: UM-BBD_reactionID:r0666 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018832 name: halohydrin hydrogen-halide-lyase B activity namespace: molecular_function def: "Catalysis of the elimination of HCl from a chloropropanol, yielding an epoxypropane." [UM-BBD_enzymeID:e0050] xref: EC:4.5.1 xref: UM-BBD_enzymeID:e0050 is_a: GO:0019181 ! halohydrin hydrogen-halide-lyase activity [Term] id: GO:0018833 name: DDT-dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane = 1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene + chloride + H(+)." [EC:4.5.1.1, RHEA:19217] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase [1,1-dichloro-2,2-bis(4-chlorophenyl)ethylene-forming]" RELATED [EC:4.5.1.1] synonym: "1,1,1-trichloro-2,2-bis(4-chlorophenyl)ethane chloride-lyase activity" EXACT [EC:4.5.1.1] synonym: "DDT dehydrochlorinase activity" EXACT [] synonym: "DDT-as" RELATED [EC:4.5.1.1] synonym: "DDT-ase activity" EXACT [EC:4.5.1.1] synonym: "DDTase activity" EXACT [EC:4.5.1.1] xref: EC:4.5.1.1 xref: KEGG:R04522 xref: MetaCyc:DDT-DEHYDROCHLORINASE-RXN xref: RHEA:19217 xref: UM-BBD_reactionID:r0439 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018834 name: dichloromethane dehalogenase activity namespace: molecular_function def: "Catalysis of the reaction: dichloromethane + H(2)O = 2 chloride + formaldehyde + 2 H(+)." [EC:4.5.1.3, RHEA:15397] synonym: "dichloromethane chloride-lyase (adding H2O; chloride-hydrolysing; formaldehyde-forming)" EXACT [EC:4.5.1.3] synonym: "dichloromethane chloride-lyase (chloride-hydrolysing)" EXACT [EC:4.5.1.3] xref: EC:4.5.1.3 xref: KEGG:R00603 xref: MetaCyc:DICHLOROMETHANE-DEHALOGENASE-RXN xref: RHEA:15397 xref: UM-BBD_reactionID:r0188 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0018835 name: carbon phosphorus lyase activity namespace: molecular_function alt_id: GO:0009456 def: "Catalysis of the reaction: alkylphosphonic acid = R-CH3 + phosphate. Substrates include aminomethylphosphonic acid (AMPA) (forms methylamine), dimethylphosphinic acid (forms methylphosphonic acid), glyphosate (forms sarcosine) and methylphosphonic acid (forms phosphate)." [PMID:3804975] xref: EC:4.7.1 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018836 name: alkylmercury lyase activity namespace: molecular_function def: "Catalysis of the reaction: R-Hg+ + H+ = R-H + Hg2+." [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase (alkane-forming)" EXACT [EC:4.99.1.2] synonym: "alkylmercury mercuric-lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercurial lyase activity" EXACT [EC:4.99.1.2] synonym: "organomercury lyase activity" EXACT [EC:4.99.1.2] xref: EC:4.99.1.2 xref: MetaCyc:ALKYLMERCURY-LYASE-RXN xref: UM-BBD_enzymeID:e0055 is_a: GO:0016829 ! lyase activity [Term] id: GO:0018837 name: 2-hydroxy-2H-benzo[h]chromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxy-2 H-benzo[h]chromene-2-carboxylate = cis -4-(1'-hydroxynaphth-2'-yl)-2-oxobut-3-enoate." [UM-BBD_reactionID:r0502] xref: UM-BBD_reactionID:r0502 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018838 name: mandelate racemase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-mandelate = (R)-mandelate." [EC:5.1.2.2] xref: EC:5.1.2.2 xref: MetaCyc:MANDELATE-RACEMASE-RXN xref: RHEA:13945 xref: UM-BBD_reactionID:r0091 is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0018839 name: cis-4-[2-(3-hydroxy)-thionaphthenyl]-2-oxo-3-butenoate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: cis-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate = trans-4-(2-(3-hydroxy)-thionaphthenyl)-2-oxo-3-butenoate." [UM-BBD_reactionID:r0163] xref: EC:5.2.1 xref: UM-BBD_reactionID:r0163 is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0018842 name: 3-carboxymuconate cycloisomerase type II activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfomuconate = 4-sulfolactone." [UM-BBD_reactionID:r0582] xref: EC:5.5.1.2 xref: RHEA:23656 xref: UM-BBD_reactionID:r0582 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018844 name: 2-hydroxytetrahydrofuran isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxytetrahydrofuran = 4-hydroxybutyraldehyde." [UM-BBD_reactionID:r0019] xref: EC:5.3.99 xref: UM-BBD_reactionID:r0019 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018845 name: 2-hydroxychromene-2-carboxylate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxychromene-2-carboxylate = (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate. (3E)-4-(2-hydroxyphenyl)-2-oxobut-3-enoate is also known as trans-o-hydroxybenzylidenepyruvate." [RHEA:27401] xref: EC:5.99.1.4 xref: KEGG:R05137 xref: MetaCyc:RXNN-386 xref: RHEA:27401 xref: UM-BBD_reactionID:r0337 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018846 name: styrene-oxide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: styrene oxide = phenylacetaldehyde." [EC:5.3.99.7, RHEA:21604] synonym: "SOI activity" EXACT [EC:5.3.99.7] synonym: "styrene oxide isomerase activity" EXACT [] synonym: "styrene-oxide isomerase (epoxide-cleaving)" EXACT [EC:5.3.99.7] xref: EC:5.3.99.7 xref: KEGG:R02615 xref: MetaCyc:STYRENE-OXIDE-ISOMERASE-RXN xref: RHEA:21604 xref: UM-BBD_reactionID:r0034 is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0018847 name: alpha-pinene lyase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene = limonene." [UM-BBD_reactionID:r0712] xref: EC:5.5.1 xref: UM-BBD_reactionID:r0712 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018848 name: pinocarveol isomerase activity namespace: molecular_function def: "Catalysis of the reaction: pinocarveol = carveol." [UM-BBD_reactionID:r0715] xref: EC:5.5.1 xref: UM-BBD_reactionID:r0715 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018849 name: muconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,5-dihydro-5-oxofuran-2-acetate = cis,cis-hexadienedioate." [EC:5.5.1.1] synonym: "2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "4-carboxymethyl-4-hydroxyisocrotonolactone lyase (decyclizing)" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate cycloisomerase activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate lactonizing enzyme I activity" EXACT [EC:5.5.1.1] synonym: "cis,cis-muconate-lactonizing enzyme" RELATED [EC:5.5.1.1] synonym: "muconate cycloisomerase I activity" EXACT [EC:5.5.1.1] synonym: "muconate lactonizing enzyme activity" EXACT [EC:5.5.1.1] xref: EC:5.5.1.1 xref: MetaCyc:MUCONATE-CYCLOISOMERASE-RXN xref: RHEA:10640 xref: UM-BBD_enzymeID:e0133 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018850 name: chloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-chloro-2,5-dihydro-5-oxofuran-2-acetate = 3-chloro-cis,cis-muconate." [EC:5.5.1.7] synonym: "2-chloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.7] synonym: "muconate cycloisomerase II activity" EXACT [EC:5.5.1.7] xref: EC:5.5.1.7 xref: RHEA:11032 xref: UM-BBD_enzymeID:e0065 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018851 name: alpha-pinene-oxide decyclase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-pinene oxide = (Z)-2-methyl-5-isopropylhexa-2,5-dienal." [EC:5.5.1.10, RHEA:16693] synonym: "alpha-pinene oxide lyase activity" EXACT [] synonym: "alpha-pinene-oxide lyase (decyclizing)" EXACT [EC:5.5.1.10] xref: EC:5.5.1.10 xref: KEGG:R04040 xref: MetaCyc:ALPHA-PINENE-OXIDE-DECYCLASE-RXN xref: RHEA:16693 xref: UM-BBD_reactionID:r0743 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018852 name: dichloromuconate cycloisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate = 2,4-dichloro-cis,cis-muconate." [EC:5.5.1.11] synonym: "2,4-dichloro-2,5-dihydro-5-oxofuran-2-acetate lyase (decyclizing)" EXACT [EC:5.5.1.11] xref: EC:5.5.1.11 xref: MetaCyc:DICHLOROMUCONATE-CYCLOISOMERASE-RXN xref: RHEA:17437 xref: UM-BBD_reactionID:r0277 is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0018853 name: obsolete perillyl-CoA synthetase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: perillic acid + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + perillyl-CoA." [UM-BBD_reactionID:r0731] comment: This term was made obsolete because it represents two reactions. synonym: "perillyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1 xref: UM-BBD_reactionID:r0731 is_obsolete: true consider: GO:0052685 consider: GO:0052686 [Term] id: GO:0018854 name: 3-isopropenyl-6-oxoheptanoyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-isopropenyl-6-oxoheptanoate + CoA-SH + ATP = H2O + ADP/AMP + mono/diphosphate + (3R)-3-isopropenyl-6-oxoheptanoyl-CoA." [UM-BBD_reactionID:r0737] xref: UM-BBD_reactionID:r0737 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018855 name: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA synthetase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetate + ATP + CoA = AMP + diphosphate + 2-oxo-delta3-4,5,5-trimethylcyclopentenylacetyl-CoA." [UM-BBD_reactionID:r0429] xref: EC:6.2.1.38 xref: UM-BBD_reactionID:r0429 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018856 name: benzoyl acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 3-oxo-3-phenylpropionate + CoA + ATP = AMP + diphosphate + benzoyl acetyl-CoA." [UM-BBD_reactionID:r0242] xref: KEGG:R05452 xref: SABIO-RK:5058 xref: UM-BBD_reactionID:r0242 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018857 name: 2,4-dichlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 2,4-dichlorobenzoate + ATP + CoASH = AMP + diphosphate + 2,4-dichlorobenzoyl-CoA." [UM-BBD_reactionID:r0137] xref: UM-BBD_reactionID:r0137 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018858 name: benzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + benzoate + CoA = AMP + benzoyl-CoA + diphosphate + H(+)." [EC:6.2.1.25, RHEA:10132] synonym: "benzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.25] synonym: "benzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl CoA synthetase (AMP forming)" EXACT [EC:6.2.1.25] synonym: "benzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.25] xref: EC:6.2.1.25 xref: KEGG:R01422 xref: MetaCyc:BENZOATE--COA-LIGASE-RXN xref: RHEA:10132 xref: UM-BBD_reactionID:r0189 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018859 name: 4-hydroxybenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-hydroxybenzoate + CoA = AMP + diphosphate + 4-hydroxybenzoyl-CoA." [EC:6.2.1.27] synonym: "4-hydroxybenzoate-CoA synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate-coenzyme A ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl coenzyme A synthetase activity" EXACT [EC:6.2.1.27] synonym: "4-hydroxybenzoyl-CoA ligase activity" EXACT [EC:6.2.1.27] xref: EC:6.2.1.27 xref: KEGG:R01300 xref: MetaCyc:4-HYDROXYBENZOATE--COA-LIGASE-RXN xref: RHEA:23116 xref: UM-BBD_reactionID:r0156 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018860 name: anthranilate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + anthranilate + CoA = AMP + diphosphate + anthranilyl-CoA." [EC:6.2.1.32] synonym: "2-aminobenzoate coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-CoA ligase activity" EXACT [EC:6.2.1.32] synonym: "2-aminobenzoate-coenzyme A ligase activity" EXACT [EC:6.2.1.32] synonym: "anthranilate--CoA ligase activity" EXACT [] synonym: "anthranilate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.32] synonym: "anthraniloyl coenzyme A synthetase activity" EXACT [EC:6.2.1.32] xref: EC:6.2.1.32 xref: KEGG:R00982 xref: MetaCyc:AMINOBENZCOALIG-RXN xref: RHEA:10828 xref: UM-BBD_reactionID:r0341 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018861 name: 4-chlorobenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: 4-chlorobenzoate + CoA + ATP = 4-chlorobenzoyl-CoA + AMP + diphosphate. This reaction requires magnesium and is part of the bacterial 2,4-dichlorobenzoate degradation pathway." [EC:6.2.1.33] synonym: "4-chlorobenzoate:CoA ligase activity" EXACT [] xref: EC:6.2.1.33 xref: KEGG:R03932 xref: MetaCyc:6.2.1.33-RXN xref: RHEA:23220 xref: UM-BBD_reactionID:r0139 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0018862 name: phenylphosphate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phenylphosphate + CO2 + H2O = H+ + phosphate + 4-hydroxybenzoate." [UM-BBD_reactionID:r0157] xref: EC:6.4.1 xref: MetaCyc:PHENYLPCARB-RXN xref: UM-BBD_reactionID:r0157 is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0018863 name: phenanthrene-9,10-epoxide hydrolase (9S,10S-forming) activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9(S),10(S)-dihydrodiolphenanthrene." [UM-BBD_reactionID:r0496] xref: EC:3.3.2 xref: UM-BBD_reactionID:r0496 is_a: GO:0019119 ! phenanthrene-9,10-epoxide hydrolase activity [Term] id: GO:0018864 name: acetylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, formula CH2CH2, the simplest of the alkynes." [ISBN:0721662544] synonym: "acetylene metabolism" EXACT [] synonym: "ethyne metabolic process" EXACT [] synonym: "ethyne metabolism" EXACT [] xref: UM-BBD_pathwayID:atl is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043452 ! cellular alkyne metabolic process [Term] id: GO:0018865 name: acrylonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [http://www.iversonsoftware.com/reference/chemistry/a/acrylonitrile.htm] synonym: "acrylonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:acr is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018866 name: adamantanone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] synonym: "adamantanone metabolism" EXACT [] xref: UM-BBD_pathwayID:ada is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018867 name: alpha-pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-pinene, a monoterpene that may be a significant factor affecting bacterial activities in nature. It is a major component in tea-tree oils, and gives off a piney smelling odor." [UM-BBD_pathwayID:apn] synonym: "alpha-pinene metabolism" EXACT [] xref: UM-BBD_pathwayID:apn is_a: GO:0033073 ! pinene metabolic process [Term] id: GO:0018868 name: 2-aminobenzenesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-aminobenzenesulfonate, aniline-o-sulfonic acid, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] synonym: "2-aminobenzenesulfonate metabolism" EXACT [] synonym: "2-aminobenzenesulphonate metabolic process" EXACT [] synonym: "2-aminobenzenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:abs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018870 name: anaerobic 2-aminobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminobenzoate, a derivative of benzoic acid with an NH2 group attached to C2, that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic 2-aminobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:abz is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043420 ! anthranilate metabolic process [Term] id: GO:0018871 name: 1-aminocyclopropane-1-carboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-aminocyclopropane-1-carboxylate, the anion of 1-aminocyclopropane-1-carboxylic acid, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants." [UM-BBD_pathwayID:acp] synonym: "1-aminocyclopropane-1-carboxylate metabolism" EXACT [] synonym: "ACP metabolic process" EXACT [] synonym: "ACP metabolism" EXACT [] xref: UM-BBD_pathwayID:acp is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0018872 name: arsonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arsonoacetate, a synthetic, organic compound containing a single arsenic atom. Arsonoacetate and other arsenic containing compounds are used in agricultural applications as animal feed additives, cotton defoliants and post-emergence grass herbicides." [UM-BBD_pathwayID:ara] synonym: "arsonoacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:ara is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018873 name: atrazine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving atrazine, a triazine ring-containing compound, widely used as a herbicide." [UM-BBD_pathwayID:atr] synonym: "atrazine metabolism" EXACT [] xref: UM-BBD_pathwayID:atr is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0018965 ! s-triazine compound metabolic process [Term] id: GO:0018874 name: benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid), a fungistatic compound widely used as a food preservative; it is conjugated to glycine in the liver and excreted as hippuric acid." [ISBN:0721662544] synonym: "benzoate metabolism" EXACT [] xref: MetaCyc:P321-PWY xref: UM-BBD_pathwayID:benz2 is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018875 name: anaerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic benzoate metabolism" EXACT [] xref: MetaCyc:CENTBENZCOA-PWY xref: UM-BBD_pathwayID:benz is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0018876 name: benzonitrile metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzonitrile. Benzonitrile is used as a solvent and chemical intermediate in the pharmaceutical, dyestuffs and rubber industries. It is highly toxic and harmful in contact with skin." [UM-BBD_pathwayID:bzn] synonym: "benzonitrile metabolism" EXACT [] xref: UM-BBD_pathwayID:bzn is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018877 name: beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:hch] synonym: "beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: UM-BBD_pathwayID:hch is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018878 name: aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,2,3,4,5,6-hexachlorocyclohexane that occur in presence of oxygen." [GOC:ai] synonym: "aerobic beta-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0018877 ! beta-1,2,3,4,5,6-hexachlorocyclohexane metabolic process [Term] id: GO:0018879 name: biphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biphenyl, a toxic aromatic hydrocarbon used as a heat transfer agent, as a fungistat in packaging citrus fruits and in plant disease control. Biphenyl can be chlorinated with 1-10 chlorine molecules to form polychlorinated biphenyls (PCBs)." [GOC:jl] synonym: "biphenyl metabolism" EXACT [] synonym: "xenene metabolic process" EXACT [] synonym: "xenene metabolism" EXACT [] xref: UM-BBD_pathwayID:bph is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018880 name: 4-chlorobiphenyl metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-chlorobiphenyl, a member of the polychlorinated biphenyl (PCB) group of compounds, a very stable group of synthetic organic compounds composed of a biphenyl nucleus with 1-10 chlorine substituents. 4-chlorobiphenyl has been used as a model substrate to investigate PCB degradation." [GOC:jl] synonym: "4-chlorobiphenyl metabolism" EXACT [] xref: UM-BBD_pathwayID:cbp is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018881 name: bromoxynil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bromoxynil, C7H3Br2NO, a dibrominated phenol derivative with a cyano (-CN) group attached. Bromoxynil is used as a herbicide for post-emergent control of annual broadleaf weeds and works by inhibiting photosynthesis in the target plants." [GOC:ai] synonym: "bromoxynil metabolism" EXACT [] xref: UM-BBD_pathwayID:box is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018882 name: (+)-camphor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving (+)-camphor, a bicyclic monoterpene ketone which is one of the major components in the leaves of common sage. Camphor exists in two enantiomers, but the (+)-isomer is more widely distributed." [UM-BBD_pathwayID:cam] synonym: "(+)-camphor metabolism" EXACT [] synonym: "camphor metabolic process" EXACT [] synonym: "camphor metabolism" EXACT [] xref: UM-BBD_pathwayID:cam is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018883 name: caprolactam metabolic process namespace: biological_process def: "The chemical reactions and pathways involving caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid used in manufacture of synthetic fibers of the polyamide type. It can cause local irritation." [CHEBI:23000, GOC:curators] synonym: "caprolactam metabolism" EXACT [] xref: UM-BBD_pathwayID:cap is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0072338 ! cellular lactam metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018884 name: carbazole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbazole, a heterocyclic aromatic compound containing a dibenzopyrrole system that is produced during coal gasification and is present in cigarette smoke. Coal tar produced at high temperature contains an average of 1.5% carbazole. It is used widely in synthesis of dyes, pharmaceuticals, and plastics and is a suspected carcinogen." [GOC:jl] synonym: "CAR metabolic process" EXACT [] synonym: "CAR metabolism" EXACT [] synonym: "carbazole metabolism" EXACT [] xref: UM-BBD_pathwayID:car is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018885 name: carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [UM-BBD_pathwayID:ctc] synonym: "carbon tetrachloride metabolism" EXACT [] xref: UM-BBD_pathwayID:ctc is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018886 name: anaerobic carbon tetrachloride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic carbon tetrachloride metabolism" EXACT [] xref: UM-BBD_pathwayID:ctc is_a: GO:0018885 ! carbon tetrachloride metabolic process [Term] id: GO:0018887 name: 4-carboxy-4'-sulfoazobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-carboxy-4'-sulfoazobenzene, a sulfonated azo compound synthesized by nitro-amine condensation from sulfanilic acid and 4-nitrobenzoic acid." [PMID:9603860] synonym: "4-carboxy-4'-sulfoazobenzene metabolism" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolic process" EXACT [] synonym: "4-carboxy-4'-sulphoazobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:csab is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018888 name: 3-chloroacrylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-chloroacrylic acid, ClHC=CHCOOH, a chlorinated derivative of acrylic acid." [GOC:ai] synonym: "3-chloroacrylic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:caa is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0018889 name: 2-chloro-N-isopropylacetanilide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-chloro-N-isopropylacetanilide, an acylanide herbicide widely used to protect corn, onion, cabbage, rose bushes, and ornamental plants." [UM-BBD_pathwayID:ppc] synonym: "2-chloro-N-isopropylacetanilide metabolism" EXACT [] synonym: "propachlor metabolic process" EXACT [] synonym: "propachlor metabolism" EXACT [] xref: UM-BBD_pathwayID:ppc is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018890 name: cyanamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanamide, NCNH2, a cyanide compound which has been used as a fertilizer, defoliant and in many manufacturing processes. It often occurs as the calcium salt, sometimes also referred to as cyanamide. The citrated calcium salt is used in the treatment of alcoholism." [CHEBI:16698, GOC:curators] synonym: "cyanamide metabolism" EXACT [] xref: UM-BBD_pathwayID:cnm is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0018891 name: cyclohexanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexanol, the monohydroxy derivative of cyclohexane. It is used as a solvent and blending agent." [ISBN:0721662544] synonym: "cyclohexanol metabolism" EXACT [] xref: UM-BBD_pathwayID:chx is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0018892 name: cyclohexylsulfamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclohexylsulfamate, also known as cyclamic acid. Sodium cyclohexylsulfamate (CHS-Na) was a widely used sweetening agent but was banned because of the suspicion of carcinogenicity and metabolic conversion to cyclohexylamine (CHA), a toxic substance. It is now used as a fungicide." [UM-BBD_pathwayID:chs] synonym: "cyclohexylsulfamate metabolism" EXACT [] synonym: "cyclohexylsulphamate metabolic process" EXACT [] synonym: "cyclohexylsulphamate metabolism" EXACT [] xref: UM-BBD_pathwayID:chs is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018893 name: dibenzofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond. Dibenzofuran is a white crystalline solid created from the production of coal tar and used as an insecticide and an intermediate in the production of other chemicals." [GOC:ai, UM-BBD_pathwayID:dbf] synonym: "dibenzofuran metabolism" EXACT [] xref: UM-BBD_pathwayID:dbf is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018894 name: dibenzo-p-dioxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds. Dibenzo-p-dioxins are generated as by-products in the manufacturing of herbicides, insecticides, fungicides, paper pulp bleaching, and in incineration, and can accumulate in milk and throughout the food chain, creating significant health concern." [UM-BBD_pathwayID:dpd] synonym: "dibenzo-p-dioxin metabolism" EXACT [] synonym: "oxanthrene metabolic process" EXACT [] synonym: "oxanthrene metabolism" EXACT [] synonym: "phenodioxin metabolic process" EXACT [] synonym: "phenodioxin metabolism" EXACT [] xref: UM-BBD_pathwayID:dpd is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018895 name: dibenzothiophene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond. Dibenzothiophene derivatives can be detected in diesel oil following hydrodesulfurization treatment to remove sulfur compounds that would otherwise generate sulfur oxides during combustion." [PMID:12147483] synonym: "dibenzothiophene metabolism" EXACT [] synonym: "diphenylene sulfide metabolic process" EXACT [] synonym: "diphenylene sulfide metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018896 name: dibenzothiophene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzothiophene breakdown" EXACT [] synonym: "dibenzothiophene catabolism" EXACT [] synonym: "dibenzothiophene degradation" EXACT [] xref: UM-BBD_pathwayID:dbt2 is_a: GO:0018895 ! dibenzothiophene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0018897 name: dibenzothiophene desulfurization namespace: biological_process def: "The removal of the sulfur atom from dibenzothiophene, a substance composed of two benzene rings linked by one sulfide bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzothiophene desulphurization" EXACT [] xref: MetaCyc:PWY-681 xref: UM-BBD_pathwayID:dbt is_a: GO:0018895 ! dibenzothiophene metabolic process [Term] id: GO:0018898 name: 2,4-dichlorobenzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorobenzoate, a chlorinated aromatic compound which is a key intermediate in the aerobic degradation of polychlorinated biphenyls (PCBs)." [GOC:jl, UM-BBD_pathwayID:dcb] synonym: "2,4-dichlorobenzoate metabolism" EXACT [] xref: UM-BBD_pathwayID:dcb is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018899 name: 1,2-dichloroethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:jl] synonym: "1,2-dichloroethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dce is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018900 name: dichloromethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dichloromethane, a dichlorinated derivative of methane. It is a colorless organic liquid with a sweet, chloroform-like odor, often used as a paint remover." [UM-BBD_pathwayID:dcm] synonym: "dichloromethane metabolism" EXACT [] xref: UM-BBD_pathwayID:dcm is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018901 name: 2,4-dichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4-dichlorophenoxyacetic acid, a chlorinated phenoxy compound which functions as a systemic herbicide and is used to control many types of broadleaf weeds." [UM-BBD_pathwayID:2\,4d] synonym: "2,4-D metabolic process" EXACT [] synonym: "2,4-D metabolism" EXACT [] synonym: "2,4-dichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4-d is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018902 name: 1,3-dichloro-2-propanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,3-dichloro-2-propanol (DCP), a halohydrin suspected of being carcinogenic, mutagenic and genotoxic. DCP is used as a general solvent, as an intermediate in organic synthesis and in paints, varnishes, lacquers, water colors, binders and photographic lacquers." [GOC:jl, UM-BBD_pathwayID:dcp] synonym: "1,3-dichloro-2-propanol metabolism" EXACT [] synonym: "DCP metabolic process" EXACT [] synonym: "DCP metabolism" EXACT [] xref: UM-BBD_pathwayID:dcp is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0018903 name: 1,3-dichloropropene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving members of the 1,3-dichloropropene family, which includes cis- and trans-1,3-dichloropropene. The 1,3-dichloropropenes are chlorinated hydrocarbons and the major active ingredients of commercial products for control of plant-parasitic nematodes." [UM-BBD_pathwayID:cpr] synonym: "1,3-dichloropropene metabolism" EXACT [] synonym: "1,3-dichloropropylene metabolic process" EXACT [] synonym: "1,3-dichloropropylene metabolism" EXACT [] synonym: "gamma-chloroallylchloride metabolic process" EXACT [] synonym: "gamma-chloroallylchloride metabolism" EXACT [] xref: UM-BBD_pathwayID:cpr is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018904 name: ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic ethers, any anhydride of the general formula R1-O-R2, formed between two identical or nonidentical organic hydroxy compounds." [GOC:pr, ISBN:0198506732] subset: goslim_pir synonym: "ether metabolism" EXACT [] synonym: "organic ether metabolic process" EXACT [] synonym: "organic ether metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018905 name: dimethyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl ether, CH3-O-CH3, the simplest ether. Dimethyl ether, also known wood ether and methyl ether, is a colorless gas that has been used in refrigeration applications." [UM-BBD_pathwayID:dme] synonym: "dimethyl ether metabolism" EXACT [] synonym: "methyl ether metabolic process" EXACT [] synonym: "methyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:dme is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0018906 name: methyl tert-butyl ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl tert-butyl ether, 2-methoxy-2-methylpropane. Methyl tert-butyl ether is a synthetic chemical which is mixed with gasoline for use in reformulated gasoline. It was first introduced as an additive for unleaded gasoline in the 1980s. It is also used as a laboratory reagent and a pharmaceutical agent." [UM-BBD_pathwayID:mtb] synonym: "methyl tert-butyl ether metabolism" EXACT [] xref: UM-BBD_pathwayID:mtb is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0018904 ! ether metabolic process [Term] id: GO:0018907 name: dimethyl sulfoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dimethyl sulfoxide, DMSO (C2H6OS), an alkyl sulfoxide that is practically odorless in its purified form. As a highly polar organic liquid, it is a powerful solvent. Its biological activities include the ability to penetrate plant and animal tissues and to preserve living cells during freezing." [CHEBI:28262, GOC:curators] synonym: "dimethyl sulfoxide metabolism" EXACT [] synonym: "dimethyl sulphoxide metabolic process" EXACT [] synonym: "dimethyl sulphoxide metabolism" EXACT [] synonym: "DMSO metabolic process" EXACT [] synonym: "DMSO metabolism" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018908 name: organosulfide cycle namespace: biological_process def: "A cyclic series of interconversions involving dimethyl sulfide, methanethiol and hydrogen sulfide. Dimethylsulfoxide can also be converted to dimethyl sulfide, which enters the cycle." [UM-BBD_pathwayID:sulf] synonym: "organosulphide cycle" EXACT [] xref: UM-BBD_pathwayID:sulf is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018909 name: dodecyl sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dodecyl sulfate, commonly found as sodium dodecyl sulfate (SDS), a component of a variety of synthetic surfactants." [UM-BBD_pathwayID:dds] synonym: "dodecyl sulfate metabolism" EXACT [] synonym: "dodecyl sulphate metabolic process" EXACT [] synonym: "dodecyl sulphate metabolism" EXACT [] xref: UM-BBD_pathwayID:dds is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018910 name: benzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzene, C6H6, a volatile, very inflammable liquid, contained in the naphtha produced by the destructive distillation of coal, from which it is separated by fractional distillation." [CHEBI:16716, GOC:ai] synonym: "benzene metabolism" EXACT [] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018911 name: 1,2,4-trichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,4-trichlorobenzene, a derivative of benzene with chlorine atoms attached to positions 1, 2 and 4 of the ring. It is a colorless liquid used as a solvent in chemical manufacturing, in dyes and intermediates, dielectric fluid, synthetic transformer oils, lubricants, heat-transfer medium and insecticides." [http://www.speclab.com/compound/c120821.htm] synonym: "1,2,4-trichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:tbz is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018912 name: 1,4-dichlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring. It forms white crystals at room temperature and is used as an insecticidal fumigant, particularly in mothballs." [http://www.speclab.com/compound/c106467.htm] synonym: "1,4-dichlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:dcz is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018913 name: anaerobic ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb is_a: GO:0018915 ! ethylbenzene metabolic process [Term] id: GO:0018914 name: chlorobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chlorobenzene, a derivative of benzene with a chlorine atoms attached to the ring. It is a colorless liquid that is manufactured for use as a solvent. It quickly evaporates in the air and is degraded by hydroxyl radicals that are produced photochemically. The gas acts as a source of ClOx, which helps in the breakdown of stratospheric ozone." [http://www.shsu.edu/] synonym: "chlorobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:cb is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018915 name: ethylbenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylbenzene (phenylethane), a benzene derivative with an ethyl group attached to the ring. It is a colorless liquid with a pungent odor used as a solvent and as a component of automotive and aviation fuels." [http://www.speclab.com/compound/c100414.htm] synonym: "ethylbenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:ethb2 is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018916 name: nitrobenzene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrobenzene (nitrobenzol), a derivative of benzene with an NO2 group attached to the ring. It is a yellow aromatic liquid used in perfumery and manufactured in large quantities in the preparation of aniline." [CHEBI:27798, GOC:curators] synonym: "nitrobenzene metabolism" EXACT [] xref: UM-BBD_pathwayID:nb is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018917 name: fluorene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [UM-BBD_pathwayID:flu] synonym: "fluorene metabolism" EXACT [] xref: UM-BBD_pathwayID:flu is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018918 name: gallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid). The esters and polyesters are widely distributed in angiosperms." [GOC:jl, ISBN:0198506732] synonym: "gallate metabolism" EXACT [] synonym: "gallic acid metabolic process" EXACT [] synonym: "gallic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:gal is_a: GO:0017144 ! drug metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018919 name: gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-1,2,3,4,5,6-hexachlorocyclohexane (also known as Lindane), the most common form of hexachlorohexane, a halogenated organic insecticide that has been used worldwide for agriculture and public health." [UM-BBD_pathwayID:ghch] synonym: "gamma-1,2,3,4,5,6-hexachlorocyclohexane metabolism" EXACT [] xref: MetaCyc:GAMMAHEXCHLORDEG-PWY xref: UM-BBD_pathwayID:ghch is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019497 ! hexachlorocyclohexane metabolic process [Term] id: GO:0018920 name: glyphosate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyphosate, a broad-spectrum herbicide also known by the trade name Roundup. It is a member of a broad class of compounds known as phosphonic acids, which contain a direct carbon-to-phosphorus (C-P) bond." [UM-BBD_pathwayID:gly] synonym: "glyphosate metabolism" EXACT [] synonym: "Roundup metabolic process" EXACT [] synonym: "Roundup metabolism" EXACT [] xref: UM-BBD_pathwayID:gly is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0018921 name: 3-hydroxybenzyl alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxybenzyl alcohol, an aromatic compound which is an intermediate in several metabolic pathways, including the biosynthesis of patulin, a toxin and antiviral agent produced by some moulds such as Penicillium patulinum." [UM-BBD_pathwayID:mcr] synonym: "3-hydroxybenzyl alcohol metabolism" EXACT [] xref: UM-BBD_pathwayID:mcr is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018922 name: iprodione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prodione, a colorless, odorless crystal. It is used as a dicarboximide contact fungicide to control a wide variety of crop diseases by inhibiting the germination of spores and the growth of the fungal mat (mycelium)." [UM-BBD_pathwayID:ipd] synonym: "iprodione metabolism" EXACT [] xref: UM-BBD_pathwayID:ipd is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0052803 ! imidazole-containing compound metabolic process [Term] id: GO:0018923 name: limonene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving limonene (4-isopropenyl-1-methyl-cyclohexene), a monocyclic monoterpene." [UM-BBD_pathwayID:lim] synonym: "limonene metabolism" EXACT [] xref: UM-BBD_pathwayID:lim is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:1900673 ! olefin metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018924 name: mandelate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:jl] synonym: "mandelate metabolism" EXACT [] synonym: "mandelic acid metabolic process" EXACT [] synonym: "mandelic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:mca is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0018925 name: m-cresol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-cresol (3-hydroxytoluene), the meta-isoform of cresol. Used to produce agricultural chemicals, and in specialty resins, pharmaceuticals and pressure-sensitive dyes." [GOC:jl] synonym: "3-hydroxytoluene metabolic process" EXACT [] synonym: "3-hydroxytoluene metabolism" EXACT [] synonym: "m-cresol metabolism" EXACT [] synonym: "meta-cresol metabolic process" EXACT [] synonym: "meta-cresol metabolism" EXACT [] xref: MetaCyc:M-CRESOL-DEGRADATION-PWY xref: UM-BBD_pathwayID:mcr is_a: GO:0042212 ! cresol metabolic process [Term] id: GO:0018926 name: methanesulfonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methanesulfonic acid, a strong acid produced by the oxidation of dimethyl sulfide." [UM-BBD_pathwayID:msa] synonym: "methanesulfonic acid metabolism" EXACT [] synonym: "methanesulphonic acid metabolic process" EXACT [] synonym: "methanesulphonic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:msa is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process [Term] id: GO:0018927 name: obsolete methionine and threonine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its use of 'and' was causing violations to the true-path rule. synonym: "methionine and threonine metabolic process" EXACT [] is_obsolete: true consider: GO:0006555 consider: GO:0006566 [Term] id: GO:0018928 name: methyl ethyl ketone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl ethyl ketone, a clear, colorless liquid with a fragrant, mint-like odor. It is used as a solvent and in making plastics, textiles and paints." [UM-BBD_pathwayID:mek] synonym: "2-butanone metabolic process" EXACT [] synonym: "2-butanone metabolism" EXACT [] synonym: "MEK metabolic process" EXACT [] synonym: "MEK metabolism" EXACT [] synonym: "methyl ethyl ketone metabolism" EXACT [] xref: UM-BBD_pathwayID:mek is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0018929 name: methyl fluoride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methyl fluoride, fluorine-substituted methane, a gaseous halogenated hydrocarbon that has been investigated as an inhibitor of methanotrophy and nitrification in soils." [UM-BBD_pathwayID:mf] synonym: "methyl fluoride metabolism" EXACT [] xref: UM-BBD_pathwayID:mf is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018930 name: 3-methylquinoline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] synonym: "3-methylquinoline metabolism" EXACT [] xref: UM-BBD_pathwayID:mqn is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018931 name: naphthalene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving naphthalene, a fused ring bicyclic aromatic hydrocarbon commonly found in crude oil and oil products. Naphthalene is familiar as the compound that gives mothballs their odor; it is used in the manufacture of plastics, dyes, solvents, and other chemicals, as well as being used as an antiseptic and insecticide." [http://www.iversonsoftware.com/reference/chemistry/n/Naphthalene.htm] synonym: "naphthalene metabolism" EXACT [] xref: UM-BBD_pathwayID:naph is_a: GO:0017144 ! drug metabolic process is_a: GO:0090420 ! naphthalene-containing compound metabolic process [Term] id: GO:0018933 name: nicotine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0018934 name: nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, an aminotricarboxylic acid that binds bivalent metal ions in a ratio of 1:1. As an important industrial chelating agent, NTA has been widely used for various radionuclide processing and decontamination procedures, such as textile, paper and pulp processing and water treatment." [UM-BBD_pathwayID:nta] synonym: "nitrilotriacetate metabolism" EXACT [] xref: UM-BBD_pathwayID:nta is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018935 name: aerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the presence of oxygen." [GOC:ai] synonym: "aerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018936 name: anaerobic nitrilotriacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrilotriacetate, the aminotricarboxylic acid N(CH2COO-)3, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic nitrilotriacetate metabolism" EXACT [] is_a: GO:0018934 ! nitrilotriacetate metabolic process [Term] id: GO:0018937 name: nitroglycerin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitroglycerin, a well-known nitrate ester and an important component of dynamite and other propellants. Toxic to algae, invertebrate, and vertebrates." [UM-BBD_pathwayID:ng] synonym: "NG metabolic process" EXACT [] synonym: "NG metabolism" EXACT [] synonym: "nitroglycerin metabolism" EXACT [] xref: MetaCyc:P201-PWY xref: UM-BBD_pathwayID:ng is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018938 name: 2-nitropropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2-nitropropane, a clear, colorless liquid with a mild, fruity odor. 2-nitropropane is used principally as a solvent and chemical intermediate. As a solvent, it is used in inks, paints, adhesives, varnishes, polymers, and synthetic materials. It is a feedstock for the manufacture of 2-nitro-2-methyl-1-propanol and 2-amino-2-methyl-1-propanol." [UM-BBD_pathwayID:npp] synonym: "2-nitropropane metabolism" EXACT [] xref: MetaCyc:PWY-723 xref: UM-BBD_pathwayID:npp is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018939 name: n-octane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving n-octane, the 8 carbon straight chain alkane used in organic syntheses, calibrations, and azeotropic distillations. It is a common component of gasoline and other petroleum products and the engine fuel antiknocking properties of an isomer of n-octane are used as a comparative standard in the Octane Rating System." [UM-BBD_pathwayID:oct] synonym: "n-octane metabolism" EXACT [] xref: UM-BBD_pathwayID:oct is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043446 ! cellular alkane metabolic process [Term] id: GO:0018940 name: orcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen, and synthesized, probably as a fungicide, by some higher plants." [GOC:jl] synonym: "orcin metabolic process" EXACT [] synonym: "orcin metabolism" EXACT [] synonym: "orcinol metabolism" EXACT [] xref: MetaCyc:P342-PWY xref: UM-BBD_pathwayID:orc is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018941 name: organomercury metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organomercury compound, any organic compound containing a mercury atom." [ISBN:0198506732] synonym: "organomercury metabolism" EXACT [] xref: UM-BBD_pathwayID:ogm is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018942 name: organometal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organometals, any metal-containing organic compound, especially one in which the metal atom is linked directly to one of more carbon atoms." [ISBN:0198506732] subset: goslim_pir synonym: "organometal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018943 name: organotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organotin, an organic compound containing a tin atom." [ISBN:0198506732] synonym: "organotin metabolism" EXACT [] is_a: GO:0018942 ! organometal metabolic process [Term] id: GO:0018944 name: tri-n-butyltin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tri-n-butyltin, an organometallic compound composed of three butyl chains attached to a tin atom. Tri-n-butyltin is used as an antifouling agent in ship bottom paints and can be toxic to many marine organisms." [GOC:ai, UM-BBD_pathwayID:tbt] synonym: "tri-n-butyltin metabolism" EXACT [] xref: UM-BBD_pathwayID:tbt is_a: GO:0018943 ! organotin metabolic process [Term] id: GO:0018945 name: organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organosilicon, organic compounds that contain silicon, a nonmetal element analogous to carbon." [GOC:jl] synonym: "organosilicon metabolism" EXACT [] synonym: "organosilicone metabolic process" EXACT [] synonym: "organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018946 name: aerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the presence of oxygen." [GOC:jl] synonym: "aerobic organosilicon metabolism" EXACT [] synonym: "aerobic organosilicone metabolic process" EXACT [] synonym: "aerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018947 name: anaerobic organosilicon metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organosilicons, organic compounds that contain silicon, in the absence of oxygen." [GOC:jl] synonym: "anaerobic organosilicon metabolism" EXACT [] synonym: "anaerobic organosilicone metabolic process" EXACT [] synonym: "anaerobic organosilicone metabolism" EXACT [] xref: UM-BBD_pathwayID:osi is_a: GO:0018945 ! organosilicon metabolic process [Term] id: GO:0018948 name: xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene." [GOC:jl] synonym: "xylene metabolism" EXACT [] is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018949 name: m-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving m-xylene, (1,3-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "m-xylene metabolism" EXACT [] synonym: "meta-xylene metabolic process" EXACT [] synonym: "meta-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:mxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018950 name: o-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "o-xylene metabolism" EXACT [] synonym: "ortho-xylene metabolic process" EXACT [] synonym: "ortho-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:oxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018951 name: p-xylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-xylene, (1,4-dimethylbenzene) a colorless, liquid aromatic hydrocarbon." [GOC:jl] synonym: "p-xylene metabolism" EXACT [] synonym: "para-xylene metabolic process" EXACT [] synonym: "para-xylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pxy is_a: GO:0018948 ! xylene metabolic process [Term] id: GO:0018952 name: parathion metabolic process namespace: biological_process def: "The chemical reactions and pathways involving parathion, a highly toxic organophosphate compound formerly used as a broad spectrum insecticide, acaricide, fumigant and nematocide. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] synonym: "parathion metabolism" EXACT [] xref: UM-BBD_pathwayID:pthn is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0018953 name: p-cymene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [UM-BBD_pathwayID:pcy] synonym: "p-cymene metabolism" EXACT [] xref: UM-BBD_pathwayID:pcy is_a: GO:0043692 ! monoterpene metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018954 name: pentaerythritol tetranitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentaerythritol tetranitrate, C(CH2-O-NO2)4, a substance produced for use as an explosive and a vasodilator." [UM-BBD_pathwayID:petn] synonym: "pentaerythritol tetranitrate metabolism" EXACT [] xref: UM-BBD_pathwayID:petn is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0018955 name: phenanthrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phenanthrene, a tricyclic aromatic hydrocarbon used in explosives and in the synthesis of dyes and drugs. Although phenanthrene is not mutagenic or carcinogenic, it has been shown to be toxic to marine diatoms, gastropods, mussels, crustaceans, and fish." [GOC:jl, UM-BBD_pathwayID:pha] synonym: "phenanthrene metabolism" EXACT [] xref: UM-BBD_pathwayID:pha is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0018956 name: phenanthrene catabolic process via trans-9(R),10(R)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(R),10(R)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha3] synonym: "phenanthrene breakdown via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(R),10(R)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha3 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018957 name: phenanthrene catabolic process via trans-9(S),10(S)-dihydrodiolphenanthrene namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon, where trans-9(S),10(S)-dihydrodiolphenanthrene is the principal intermediate metabolite." [UM-BBD_pathwayID:pha2] synonym: "phenanthrene breakdown via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] synonym: "phenanthrene degradation via trans-9(S),10(S)-dihydrodiolphenanthrene" EXACT [] xref: UM-BBD_pathwayID:pha2 is_a: GO:0042216 ! phenanthrene catabolic process [Term] id: GO:0018958 name: phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, ISBN:0198506732] comment: Note that phenol metabolism is not included as a child of 'xenobiotic metabolism' because although it is synthesized industrially, phenol is also found naturally in animal wastes and other organic materials. It is often formed by the activity of microorganisms, which can chemically modify a variety of xenobiotic and naturally occurring phenolic compounds. synonym: "carbolic acid metabolic process" EXACT [] synonym: "carbolic acid metabolism" EXACT [] synonym: "hydroxybenzene metabolic process" EXACT [] synonym: "hydroxybenzene metabolism" EXACT [] synonym: "phenol-containing compound metabolism" EXACT [GOC:curators] xref: UM-BBD_pathwayID:phe is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0018959 name: aerobic phenol-containing compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the presence of oxygen." [CHEBI:33853, ISBN:0198506732] synonym: "aerobic phenol-containing compound metabolism" EXACT [GOC:curators] xref: UM-BBD_pathwayID:pba is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018960 name: 4-nitrophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrophenol, a nitroaromatic compound which is used in the production of dyes, leather treatment agents, fungicides and as an intermediate in the production of the insecticide parathion." [GOC:jl] synonym: "4-nitrophenol metabolism" EXACT [] synonym: "p-nitrophenol metabolic process" EXACT [] synonym: "p-nitrophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:nphe is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0018961 name: pentachlorophenol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [UM-BBD_pathwayID:pcp] synonym: "PCP metabolic process" EXACT [] synonym: "PCP metabolism" EXACT [] synonym: "pentachlorophenol metabolism" EXACT [] xref: UM-BBD_pathwayID:pcp is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018962 name: 3-phenylpropionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-phenylpropionate, the anion of phenylpropanoic acid. It is produced from putrefaction of proteins in soil or breakdown of several constituents of plants, such as lignin, various oils and resins." [GOC:ai, UM-BBD_pathwayID:ppa] synonym: "3-phenylpropionate metabolism" EXACT [] synonym: "hydrocinnamic acid metabolic process" EXACT [] synonym: "hydrocinnamic acid metabolism" EXACT [] synonym: "phenylpropanoate metabolic process" EXACT [] synonym: "phenylpropanoate metabolism" EXACT [] xref: UM-BBD_pathwayID:ppa is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018963 name: phthalate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phthalate, the anion of phthalic acid. Phthalic acid diesters are used industrially in the production of a variety of household and consumer goods including plastic polymers, lubricating oils, and carriers for perfumes in cosmetics, while phthalic acid itself is used industrially as a plasticizer. Terephthalate is used in the synthesis of polyethylene terephthalate (polyethene terephthlate, abbreviated PET or PETE), a plastic polymer with many commercial uses." [UM-BBD_pathwayID:pth] synonym: "phthalate metabolism" EXACT [] synonym: "phthalic acid metabolic process" EXACT [] synonym: "phthalic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:pth is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0018964 name: propylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining. It is used mainly in the preparation of alkylates for gasoline and in the production of polypropylene, acrylonitrile, propylene oxide and a number of other industrial chemicals." [GOC:jl] synonym: "propylene metabolism" EXACT [] xref: UM-BBD_pathwayID:pro is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0018965 name: s-triazine compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms." [UM-BBD_pathwayID:tria] synonym: "s-triazine compound metabolism" EXACT [] xref: UM-BBD_pathwayID:tria is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0018966 name: styrene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving styrene, an aromatic hydrocarbon liquid soluble in ether and alcohol. When heated, exposed to light or added to a peroxide catalyst, it undergoes polymerization to form polystyrene, a versatile material used in the manufacture of plastics, synthetic rubber, thermal insulation, and packaging. Styrene is a classified mutagen and a suspected carcinogen." [GOC:jl, UM-BBD_pathwayID:sty] synonym: "styrene metabolism" EXACT [] xref: UM-BBD_pathwayID:sty is_a: GO:0042537 ! benzene-containing compound metabolic process is_a: GO:1900673 ! olefin metabolic process [Term] id: GO:0018967 name: tetrachloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrachloroethylene (tetrachloroethene), a derivative of ethene with the hydrogen atoms replaced by chlorines. Tetrachloroethene has been used primarily as a solvent in dry-cleaning industries and to a lesser extent as a degreasing solvent." [http://www.who.int/water_sanitation_health/GDWQ/Chemicals/tetrachloroethenesum.htm] synonym: "tetrachloroethene metabolic process" EXACT [] synonym: "tetrachloroethene metabolism" EXACT [] synonym: "tetrachloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce2 is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018968 name: tetrahydrofuran metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrahydrofuran, a cyclic 4 carbon ether. It is one of the most polar ethers and is a widely used solvent for polar reagents. Since THF is very soluble in water and has a relatively low boiling point, significant amounts are often released into the environment, causing contamination problems." [UM-BBD_pathwayID:thf] synonym: "tetrahydrofuran metabolism" EXACT [] synonym: "THF metabolic process" EXACT [] synonym: "THF metabolism" EXACT [] xref: UM-BBD_pathwayID:thf is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0097176 ! epoxide metabolic process [Term] id: GO:0018969 name: thiocyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiocyanate, the anion of thiocyanic acid, a toxic cyanide derivative commonly formed as a by-product in the production of gas for fuel, coke, and substances for chemical industries." [GOC:jl] synonym: "thiocyanate metabolism" EXACT [] synonym: "thiocyanic acid metabolic process" EXACT [] synonym: "thiocyanic acid metabolism" EXACT [] xref: MetaCyc:P581-PWY xref: UM-BBD_pathwayID:thc is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0006805 ! xenobiotic metabolic process [Term] id: GO:0018970 name: toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products such as gasoline and commonly used as a paint thinning agent and in other solvent applications." [UM-BBD_pathwayID:tol] synonym: "methylbenzene metabolic process" EXACT [] synonym: "methylbenzene metabolism" EXACT [] synonym: "toluene metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018971 name: anaerobic toluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic toluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tol2 is_a: GO:0018970 ! toluene metabolic process [Term] id: GO:0018972 name: toluene-4-sulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving toluene-4-sulfonate, the anion of 4-toluene sulfonic acid, a white crystalline solid which is highly hygroscopic and soluble in water." [GOC:ai] synonym: "4-methylbenzenesulfonate metabolic process" EXACT [] synonym: "4-methylbenzenesulfonate metabolism" EXACT [] synonym: "4-toluenesulfonate metabolic process" EXACT [] synonym: "4-toluenesulfonate metabolism" EXACT [] synonym: "toluene-4-sulfonate metabolism" EXACT [] synonym: "toluene-4-sulphonate metabolic process" EXACT [] synonym: "toluene-4-sulphonate metabolism" EXACT [] xref: MetaCyc:TOLSULFDEG-PWY xref: UM-BBD_pathwayID:tsa is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0018973 name: trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trinitrotoluene, a methylated benzene molecule with three NO2 groups attached to it. This includes the explosive TNT, 1-methyl-2,4,6-trinitrobenzene." [GOC:ai] synonym: "trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0018974 name: 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid. It is prepared from toluene treated with concentrated sulfuric and nitric acids and is used in shells, bombs, and blasting explosives." [ISBN:0333781767] synonym: "2,4,6-trinitrotoluene metabolism" EXACT [] synonym: "TNT metabolic process" EXACT [] synonym: "TNT metabolism" EXACT [] is_a: GO:0018973 ! trinitrotoluene metabolic process [Term] id: GO:0018975 name: anaerobic 2,4,6-trinitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,6-trinitrotoluene, 1-methyl-2,4,6-trinitrobenzene, a highly explosive pale yellow crystalline solid, that occur in the absence of oxygen." [GOC:ai] synonym: "anaerobic 2,4,6-trinitrotoluene metabolism" EXACT [] xref: UM-BBD_pathwayID:tnt2 is_a: GO:0018974 ! 2,4,6-trinitrotoluene metabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0018976 name: 1,2,3-tribromopropane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,2,3-tribromopropane, a toxic and volatile organic compound commonly used as a nematocide in agriculture." [GOC:jl] synonym: "1,2,3-tribromopropane metabolism" EXACT [] xref: UM-BBD_pathwayID:tbp is_a: GO:0042197 ! halogenated hydrocarbon metabolic process [Term] id: GO:0018977 name: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide." [GOC:jl] synonym: "1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "DDT metabolic process" EXACT [] synonym: "DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt is_a: GO:0017143 ! insecticide metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018978 name: anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated, broad spectrum, contact insecticide, in the absence of oxygen." [GOC:jl] synonym: "anaerobic 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolism" EXACT [] synonym: "anaerobic DDT metabolic process" EXACT [] synonym: "anaerobic DDT metabolism" EXACT [] xref: UM-BBD_pathwayID:ddt2 is_a: GO:0018977 ! 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane metabolic process [Term] id: GO:0018979 name: trichloroethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trichloroethylene, a toxic, colorless, photoreactive, chlorinated hydrocarbon liquid, commonly used as a metal degreaser and solvent." [GOC:jl] synonym: "TCE metabolic process" EXACT [] synonym: "TCE metabolism" EXACT [] synonym: "trichloroethene metabolic process" EXACT [] synonym: "trichloroethene metabolism" EXACT [] synonym: "trichloroethylene metabolism" EXACT [] xref: UM-BBD_pathwayID:tce is_a: GO:0017144 ! drug metabolic process is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0018980 name: 2,4,5-trichlorophenoxyacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 2,4,5-trichlorophenoxyacetic acid, a chlorinated aromatic compound which is widely used as a herbicide, often as a weed killer for home lawns." [UM-BBD_pathwayID:2\,4\,5-t] synonym: "2,4,5-T metabolic process" EXACT [] synonym: "2,4,5-T metabolism" EXACT [] synonym: "2,4,5-trichlorophenoxyacetic acid metabolism" EXACT [] xref: UM-BBD_pathwayID:2\,4\,5-t is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0009850 ! auxin metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018981 name: triethanolamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triethanolamine, a combustible, hygroscopic, colorless liquid commonly used in dry-cleaning solutions, cosmetics, detergents, textile processing, wool scouring, and as a corrosion inhibitor and pharmaceutical alkalizing agent." [GOC:jl] synonym: "triethanolamine metabolism" EXACT [] xref: UM-BBD_pathwayID:tea is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0044107 ! cellular alcohol metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0018982 name: vanillin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods and can be obtained as a by-product of the pulp and paper industry by the oxidative breakdown of lignin." [GOC:jl] synonym: "vanillic aldehyde metabolic process" EXACT [] synonym: "vanillic aldehyde metabolism" EXACT [] synonym: "vanillin metabolism" EXACT [] xref: UM-BBD_pathwayID:van is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0018983 name: Z-phenylacetaldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving Z-phenylacetaldoxime, a member of the glucosinolate group of compounds, a class of natural products that are gaining increasing interest as cancer-preventing agents and crop protectants." [UM-BBD_pathwayID:car] synonym: "Z-phenylacetaldoxime metabolism" EXACT [] xref: UM-BBD_pathwayID:pao is_a: GO:0019330 ! aldoxime metabolic process [Term] id: GO:0018984 name: naphthalenesulfonate metabolic process namespace: biological_process alt_id: GO:0018932 def: "The chemical reactions and pathways involving naphthalenesulfonate, sulfonated derivatives of naphthalene." [GOC:ai] synonym: "naphthalenesulfonate metabolism" EXACT [] synonym: "naphthalenesulphonate metabolic process" EXACT [] synonym: "naphthalenesulphonate metabolism" EXACT [] xref: UM-BBD_pathwayID:nphs is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0018985 name: pronuclear envelope synthesis namespace: biological_process def: "Synthesis and ordering of the envelope of pronuclei." [GOC:ems] is_a: GO:0006998 ! nuclear envelope organization is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0018988 name: obsolete molting cycle, protein-based cuticle namespace: biological_process def: "OBSOLETE. The periodic shedding of part or all of a protein-based cuticle, which is then replaced by a new protein-based cuticle. A cuticle is the outer layer of an animal which acts to prevent water loss." [GOC:ems, GOC:mtg_sensu] comment: This term was made obsolete because 'protein-based cuticle' is an unnecessary grouping term. synonym: "protein-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_obsolete: true consider: GO:0007591 consider: GO:0018996 [Term] id: GO:0018989 name: apolysis namespace: biological_process def: "The first process of molting, characterized by the detachment of the old cuticle from the underlying epidermal cells." [GOC:jl] xref: Wikipedia:Apolysis is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018990 name: ecdysis, chitin-based cuticle namespace: biological_process def: "The shedding of the old chitin-based cuticlar fragments during the molting cycle. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0018991 name: oviposition namespace: biological_process def: "The deposition of eggs (either fertilized or not) upon a surface or into a medium such as water." [GOC:ems] synonym: "egg laying" BROAD [] synonym: "egg-laying" BROAD [] xref: Wikipedia:Oviposition is_a: GO:0019098 ! reproductive behavior [Term] id: GO:0018992 name: germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in an organism's germ line." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0018993 name: somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in an organism's soma." [GOC:ems] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0018995 name: host namespace: cellular_component def: "Any organism in which another organism, especially a parasite or symbiont, spends part or all of its life cycle and from which it obtains nourishment and/or protection." [ISBN:0198506732] synonym: "host organism" EXACT [] xref: Wikipedia:Host_(biology) is_a: GO:0044215 ! other organism [Term] id: GO:0018996 name: molting cycle, collagen and cuticulin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a collagen and cuticulin-based cuticle, which is then replaced by a new collagen and cuticulin-based cuticle. An example of this is found in the Nematode worm, Caenorhabditis elegans." [GOC:jl, GOC:mtg_sensu] synonym: "collagen and cuticulin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0042303 ! molting cycle [Term] id: GO:0018997 name: obsolete electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the parent terms cover its function. synonym: "electron transfer carrier" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0018998 name: obsolete metaxin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "metaxin" EXACT [] is_obsolete: true consider: GO:0005741 [Term] id: GO:0019000 name: obsolete endonuclease G activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12444964, PMID:12928502, PMID:12941691] comment: This term was made obsolete because it represents a gene product. synonym: "endonuclease G activity" EXACT [] is_obsolete: true consider: GO:0004520 consider: GO:0004521 [Term] id: GO:0019001 name: guanyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanyl nucleotides, any compound consisting of guanosine esterified with (ortho)phosphate." [ISBN:0198506732] xref: reactome:R-HSA-156909 "eEF1A complexes with GTP" is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0019002 name: GMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GMP, guanosine monophosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0019003 name: GDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GDP, guanosine 5'-diphosphate." [GOC:ai] is_a: GO:0032550 ! purine ribonucleoside binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0019005 name: SCF ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1)." [PMID:15571813, PMID:15688063] synonym: "CDL1 complex" EXACT [] synonym: "CRL1 complex" EXACT [] synonym: "Cul1-RING ubiquitin ligase complex" EXACT [] synonym: "cullin-RING ligase 1" EXACT [] synonym: "SCF complex" EXACT [] synonym: "SCF complex substrate recognition subunit" NARROW [] synonym: "Skp1/Cul1/F-box protein complex" EXACT [] xref: Wikipedia:SCF_complex is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0019008 name: molybdopterin synthase complex namespace: cellular_component alt_id: GO:0019009 def: "A protein complex that possesses molybdopterin synthase activity. In E. coli, the complex is a heterotetramer consisting of two MoaD and two MoaE subunits." [GOC:mah, PMID:12571227, PMID:15709772] subset: goslim_metagenomics synonym: "molybdopterin converting factor complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0019010 name: farnesoic acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: farnesoic acid + S-adenosyl-methionine = methyl farnesoate + S-adenosyl-L-homocysteine." [PMID:12135499] synonym: "S-adenosyl-methionine:farnesoic acid O-methyltransferase activity" EXACT [] is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0019011 name: obsolete DNA replication accessory factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication accessory factor" EXACT [] is_obsolete: true consider: GO:0006260 [Term] id: GO:0019012 name: virion namespace: cellular_component def: "The complete fully infectious extracellular virus particle." [ISBN:0781718325] subset: goslim_chembl subset: goslim_metagenomics subset: goslim_pir synonym: "complete virus particle" EXACT [] xref: Wikipedia:Virus is_a: GO:0005575 ! cellular_component [Term] id: GO:0019013 name: viral nucleocapsid namespace: cellular_component alt_id: GO:0019014 def: "The complete protein-nucleic acid complex that is the packaged form of the genome in a virus particle." [ISBN:0781702534] subset: goslim_chembl synonym: "core" BROAD [] synonym: "nucleocapsid" EXACT [] is_a: GO:0044423 ! virion part relationship: part_of GO:0019028 ! viral capsid [Term] id: GO:0019015 name: obsolete viral genome namespace: cellular_component def: "OBSOLETE. The whole of the genetic information of a virus, contained as either DNA or RNA." [ISBN:0198506732] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019016 name: obsolete non-segmented viral genome namespace: cellular_component def: "OBSOLETE. A viral genome that consists of one continuous nucleic acid molecule." [GOC:pk] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019017 name: obsolete segmented viral genome namespace: cellular_component def: "OBSOLETE. A viral genome that is divided into two or more physically separate molecules of nucleic acid and packaged into a single virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019018 name: obsolete bipartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of two sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019019 name: obsolete tripartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019020 name: obsolete multipartite viral genome namespace: cellular_component def: "OBSOLETE. A segmented viral genome consisting of more than three sub-genomic nucleic acids but each nucleic acid is packaged into a different virion." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019021 name: obsolete DNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of deoxyribonucleic acid." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019022 name: obsolete RNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of ribonucleic acid. This results in genome replication and expression of genetic information being inextricably linked." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019023 name: obsolete dsRNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of double stranded RNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019024 name: obsolete ssRNA viral genome namespace: cellular_component def: "OBSOLETE. A viral genome composed of single stranded RNA of either positive or negative sense." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019025 name: obsolete positive sense viral genome namespace: cellular_component def: "OBSOLETE. A single stranded RNA genome with the same nucleotide polarity as mRNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019026 name: obsolete negative sense viral genome namespace: cellular_component def: "OBSOLETE. A single stranded RNA genome with the opposite nucleotide polarity as mRNA." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019027 name: obsolete ambisense viral genome namespace: cellular_component def: "OBSOLETE. A RNA genome that contains coding regions that are either positive sense or negative sense on the same RNA molecule." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. is_obsolete: true [Term] id: GO:0019028 name: viral capsid namespace: cellular_component alt_id: GO:0046728 def: "The protein coat that surrounds the infective nucleic acid in some virus particles. It comprises numerous regularly arranged subunits, or capsomeres." [GOC:mtg_sensu, ISBN:0198506732] subset: goslim_chembl xref: Wikipedia:Capsid is_a: GO:0044423 ! virion part [Term] id: GO:0019029 name: helical viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form a protein helix with the genetic material contained within. Tobacco mosaic virus has such a capsid structure." [ISBN:071673706X, UniProtKB-KW:KW-1139, VZ:885] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019030 name: icosahedral viral capsid namespace: cellular_component def: "The protein coat that surrounds the infective nucleic acid in some virus particles; the subunits are arranged to form an icosahedron, a solid with 20 faces and 12 vertices. Icosahedral capsids have 12 pentamers plus 10(T-1) hexamers, where T is the triangulation number. Tobacco satellite necrosis virus has such a capsid structure." [GOC:bm, ISBN:0198506732, ISBN:071673706X, VZ:885, Wikipedia:Capsid] synonym: "quasispherical viral capsid" EXACT [] is_a: GO:0019028 ! viral capsid [Term] id: GO:0019031 name: viral envelope namespace: cellular_component def: "The lipid bilayer of a virion that surrounds the protein capsid. May also contain glycoproteins." [GOC:bf, GOC:bm, GOC:jl, ISBN:0781718325, Wikipedia:Viral_envelope] subset: goslim_chembl synonym: "viral glycoprotein" RELATED [] synonym: "viral outside membrane" EXACT [] xref: Wikipedia:Viral_envelope is_a: GO:0036338 ! viral membrane [Term] id: GO:0019032 name: obsolete viral glycoprotein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a type of gene product and not a location or complex. synonym: "viral glycoprotein" EXACT [] is_obsolete: true consider: GO:0019031 [Term] id: GO:0019033 name: viral tegument namespace: cellular_component def: "A structure lying between the capsid and envelope of a virus, varying in thickness and often distributed asymmetrically." [ISBN:0721662544] xref: Wikipedia:Viral_tegument is_a: GO:0044423 ! virion part [Term] id: GO:0019034 name: viral replication complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in replicating the viral genome." [ISBN:0781718325] is_a: GO:0044094 ! host cell nuclear part [Term] id: GO:0019035 name: viral integration complex namespace: cellular_component def: "A nucleoprotein complex containing viral genetic material and associated viral and host proteins, which is capable of inserting a viral genome into a host genome." [ISBN:0781718325, PMID:16712776, Wikipedia:Pre-integration_complex] synonym: "PIC" EXACT [PMID:16712776] synonym: "pre-integration complex" EXACT [PMID:16712776] is_a: GO:0032991 ! protein-containing complex is_a: GO:0043657 ! host cell [Term] id: GO:0019036 name: viral transcriptional complex namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in transcribing the viral genome." [ISBN:0781718325] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019037 name: viral assembly intermediate namespace: cellular_component def: "Specific locations and structures in the virus infected cell involved in assembling new virions." [ISBN:0781718325] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019038 name: obsolete provirus namespace: cellular_component def: "OBSOLETE. The name given to a viral genome after it has been integrated into the host genome; particularly applies to retroviruses and is a required part of the retroviral replication cycle." [ISBN:0121585336] comment: This term was obsoleted because it does not represent a GO cellular component. xref: Wikipedia:Provirus is_obsolete: true [Term] id: GO:0019039 name: obsolete viral-cell fusion molecule activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "viral-cell fusion molecule activity" EXACT [] is_obsolete: true consider: GO:0019064 consider: GO:0050839 [Term] id: GO:0019040 name: obsolete viral host shutoff protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "viral host shutoff protein" EXACT [] is_obsolete: true consider: GO:0004534 consider: GO:0019057 [Term] id: GO:0019042 name: viral latency namespace: biological_process alt_id: GO:0030069 alt_id: GO:0075710 def: "The process by which, after initial infection, a virus lies dormant within a cell and viral production ceases. The process ends when the virus switches from latency and starts to replicate." [GOC:jl] synonym: "latent virus infection" EXACT [] synonym: "phage lysogeny" EXACT [] synonym: "viral dormancy" EXACT [] is_a: GO:0016032 ! viral process [Term] id: GO:0019043 name: establishment of viral latency namespace: biological_process alt_id: GO:0075601 def: "A process by which a virus establishes a latent state within its host, either as an integrated provirus within the host genome or as an episome, where viral genome remains in the cytoplasm or nucleus as distinct objects." [GOC:jl] synonym: "lysogenic commitment" EXACT [] synonym: "phage lysogeny" NARROW [] xref: PHI:0000007 is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019044 name: maintenance of viral latency namespace: biological_process alt_id: GO:0032360 alt_id: GO:0075716 def: "The perpetuation of a latent state, generally by repressing the viruses own lytic genes expression and ensuring expression of viral genes which function to keep the viral genome from being detected by the host defense mechanisms." [GOC:jl] synonym: "latent virus maintenance" EXACT [] synonym: "prophage maintenance" EXACT [] synonym: "provirus maintenance" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019045 name: latent virus replication namespace: biological_process def: "Any process required for latent viral replication in a cell." [ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019042 ! viral latency [Term] id: GO:0019046 name: release from viral latency namespace: biological_process alt_id: GO:0075717 def: "The process by which a virus begins to replicate following a latency replication decision (switch)." [GOC:dos, GOC:jl] is_a: GO:0016032 ! viral process relationship: part_of GO:0019045 ! latent virus replication [Term] id: GO:0019048 name: modulation by virus of host morphology or physiology namespace: biological_process alt_id: GO:0044792 def: "The process in which a virus effects a change in the structure or processes of its host organism." [GOC:bf, GOC:jl, ISBN:0781718325, UniProtKB-KW:KW-0945] synonym: "host-virus interaction" EXACT [GOC:bf, GOC:jl] synonym: "modulation by virus of host anatomical structure or process" EXACT [GOC:bf, GOC:jl] synonym: "modulation by virus of host anatomy or process" EXACT [GOC:bf, GOC:jl] synonym: "viral interaction with host" EXACT [] synonym: "viral-host process" EXACT [GOC:bf, GOC:jl] synonym: "virus-host interaction" BROAD [GOC:bf, GOC:jl] synonym: "virus-host process" EXACT [GOC:bf, GOC:jl] xref: VZ:886 "Vertebrate host-virus interactions" is_a: GO:0016032 ! viral process is_a: GO:0044003 ! modification by symbiont of host morphology or physiology [Term] id: GO:0019049 name: evasion or tolerance of host defenses by virus namespace: biological_process def: "Any process, either active or passive, by which a virus avoids or tolerates the effects of its host organism's defense(s). Host defenses may be induced by the presence of the virus or may be preformed (e.g. physical barriers). The host is defined as the larger of the organisms involved in a symbiotic interaction." [ISBN:1555811272] synonym: "evasion of host defenses by virus" NARROW [GOC:bf, GOC:bm, GOC:jl] synonym: "viral host defence evasion" NARROW [] synonym: "viral host defense evasion" NARROW [] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0044415 ! evasion or tolerance of host defenses [Term] id: GO:0019050 name: suppression by virus of host apoptotic process namespace: biological_process def: "Any viral process that inhibits apoptosis of infected host cells, facilitating prolonged cell survival during viral replication." [GOC:mtg_apoptosis, ISBN:0781718325] synonym: "negative regulation by virus of host apoptosis" EXACT [] synonym: "negative regulation of apoptosis by virus" EXACT [] synonym: "suppression by virus of host apoptosis" EXACT [] synonym: "suppression of apoptosis in host by virus" EXACT [] is_a: GO:0033668 ! negative regulation by symbiont of host apoptotic process is_a: GO:0039526 ! modulation by virus of host apoptotic process [Term] id: GO:0019051 name: induction by virus of host apoptotic process namespace: biological_process def: "The set of viral processes that induce an apoptotic process in infected host cells, facilitating release and spread of progeny virions." [GOC:mtg_apoptosis, ISBN:0781718325] synonym: "activation by virus of host apoptosis" EXACT [] synonym: "activation by virus of host apoptotic programmed cell death" EXACT [] synonym: "activation of apoptosis in host by virus" EXACT [] synonym: "induction by virus of host apoptosis" NARROW [] synonym: "induction by virus of host apoptotic programmed cell death" EXACT [] synonym: "induction of apoptosis in host by virus" EXACT [] is_a: GO:0039526 ! modulation by virus of host apoptotic process is_a: GO:0060139 ! positive regulation of apoptotic process by virus [Term] id: GO:0019054 name: modulation by virus of host process namespace: biological_process def: "The process in which a virus effects a change in the processes and activities of its host organism." [GOC:jl] synonym: "modification by virus of host cellular process" EXACT [] synonym: "modulation of cellular process in host by virus" RELATED [] synonym: "regulation by virus of host cellular process" EXACT [] synonym: "regulation of cellular process in host by virus" EXACT [] synonym: "regulation of host cellular process by virus" EXACT [] synonym: "viral host cell process manipulation" EXACT [] is_a: GO:0019048 ! modulation by virus of host morphology or physiology is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0019055 name: modification by virus of host cell cycle regulation namespace: biological_process def: "Interactions, directly with the host cell macromolecular machinery, to allow a virus to modulate the rate of the host cell cycle to facilitate virus replication." [GOC:dph, ISBN:0781718325] synonym: "viral perturbation of cell cycle regulation" EXACT [] is_a: GO:0019054 ! modulation by virus of host process [Term] id: GO:0019056 name: modulation by virus of host transcription namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of its host's transcription." [ISBN:0781718325] synonym: "modification by virus of host transcription" EXACT [] synonym: "viral perturbation of host cell transcription" EXACT [] is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0052026 ! modulation by symbiont of host transcription [Term] id: GO:0019057 name: modulation by virus of host translation namespace: biological_process def: "Any process in which a virus modulates the frequency, rate or extent of translation of host mRNA." [ISBN:0781718325] synonym: "host cell protein synthesis shutoff" BROAD [] synonym: "host cell shutoff" BROAD [] synonym: "modification by virus of host cell mRNA translation" EXACT [] synonym: "modulation of host translation by virus" EXACT [GOC:bf] synonym: "regulation of host mRNA translation by virus" EXACT [] synonym: "regulation of host translation by virus" EXACT [] synonym: "regulation of translation in host by virus" EXACT [] synonym: "viral host shutoff protein" RELATED [] synonym: "viral perturbation of host cell mRNA translation" EXACT [] is_a: GO:0039656 ! modulation by virus of host gene expression is_a: GO:0044073 ! modulation by symbiont of host translation [Term] id: GO:0019058 name: viral life cycle namespace: biological_process alt_id: GO:0019067 def: "A set of processes which all viruses follow to ensure survival; includes attachment and entry of the virus particle, decoding of genome information, translation of viral mRNA by host ribosomes, genome replication, and assembly and release of viral particles containing the genome." [ISBN:1555811272] synonym: "lytic viral life cycle" RELATED [] synonym: "viral assembly, maturation, egress, and release" NARROW [GOC:bf, GOC:jl] synonym: "viral infectious cycle" RELATED [GOC:bf, GOC:jl] synonym: "viral replication" RELATED [GOC:bf, GOC:jl] is_a: GO:0016032 ! viral process [Term] id: GO:0019059 name: obsolete initiation of viral infection namespace: biological_process def: "OBSOLETE. The set of processes involved in the start of virus infection of cells." [ISBN:0781702534] comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. synonym: "initiation of viral infection" EXACT [] is_obsolete: true consider: GO:0046718 [Term] id: GO:0019060 name: intracellular transport of viral protein in host cell namespace: biological_process alt_id: GO:0046742 alt_id: GO:0046743 alt_id: GO:0046801 def: "The directed movement of a viral protein within the host cell." [GOC:ai, ISBN:0781702534, ISBN:0781718325, PMID:11581394, PMID:9188566] comment: This term is for annotation of proteins responsible for the movement of individual viral proteins, rather than the whole viral particle. synonym: "cytoplasmic viral capsid transport" NARROW [] synonym: "intracellular transport of viral capsid in host cell" NARROW [] synonym: "intracellular transport of viral capsid protein in host cell" NARROW [] synonym: "intracellular transport of viral proteins in host cell" EXACT [] synonym: "intracellular viral capsid transport" NARROW [] synonym: "intracellular viral protein transport" EXACT [] synonym: "nuclear viral capsid transport" NARROW [] synonym: "viral capsid transport in host cell cytoplasm" NARROW [] synonym: "viral capsid transport in host cell nucleus" NARROW [] is_a: GO:0030581 ! symbiont intracellular protein transport in host relationship: part_of GO:0046719 ! regulation by virus of viral protein levels in host cell [Term] id: GO:0019061 name: uncoating of virus namespace: biological_process def: "The process by which an incoming virus is disassembled in the host cell to release a replication-competent viral genome." [GOC:plm, ISBN:0781702534, PMID:8162442] synonym: "viral uncoating" EXACT [PMID:8162442] is_a: GO:0016032 ! viral process [Term] id: GO:0019062 name: virion attachment to host cell namespace: biological_process def: "The process by which a virion protein binds to molecules on the host cellular surface or host cell surface projection." [GOC:bf, GOC:jl, UniProtKB-KW:KW-1161, VZ:956] synonym: "viral absorption" EXACT [] synonym: "viral attachment to host cell" RELATED [GOC:bf, GOC:jl] synonym: "virion attachment to host cell surface receptor" NARROW [] xref: VZ:956 "Viral attachment to host cell" is_a: GO:0044650 ! adhesion of symbiont to host cell relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019064 name: fusion of virus membrane with host plasma membrane namespace: biological_process alt_id: GO:0075706 def: "Fusion of a viral membrane with the host cell membrane during viral entry. Results in release of the virion contents into the cytoplasm." [GOC:bf, GOC:jl] synonym: "viral entry into host cell via membrane fusion with the plasma membrane" RELATED [GOC:bf, GOC:jl] synonym: "viral envelope fusion" BROAD [] synonym: "viral envelope fusion with host cell membrane" EXACT [] synonym: "viral envelope fusion with host membrane" EXACT [] synonym: "viral envelope fusion with host plasma membrane" EXACT [] synonym: "viral penetration via membrane fusion" BROAD [] synonym: "viral-cell fusion molecule activity" RELATED [] xref: VZ:987 "Fusion of virus membrane with host cell membrane" is_a: GO:0039663 ! membrane fusion involved in viral entry into host cell [Term] id: GO:0019065 name: receptor-mediated endocytosis of virus by host cell namespace: biological_process def: "Any receptor-mediated endocytosis that is involved in the uptake of a virus into a host cell; successive instances of virus endocytosis result in the accumulation of virus particles within the cell." [GOC:bf, GOC:jl, ISBN:0781702534] synonym: "receptor mediated endocytosis by host of virus particle" EXACT [] synonym: "receptor mediated endocytosis of virus by host" EXACT [] synonym: "receptor mediated endocytosis of virus particle by host" EXACT [] synonym: "receptor-mediated endocytosis of virus by host" EXACT [] synonym: "viral entry into host cell via receptor-mediated endocytosis" RELATED [GOC:bf, GOC:jl] synonym: "viral receptor mediated endocytosis" EXACT [] synonym: "virus receptor-mediated endocytosis by host" EXACT [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0075509 ! endocytosis involved in viral entry into host cell [Term] id: GO:0019066 name: obsolete translocation of virus into host cell namespace: biological_process def: "OBSOLETE. The translocation of an entire virus particle across the host cell plasma membrane." [ISBN:0781702534] comment: This term was made obsolete because it is ambiguous, and more specific terms have been created. synonym: "translocation of virus into host cell" EXACT [] synonym: "viral translocation" EXACT [] is_obsolete: true replaced_by: GO:0046718 [Term] id: GO:0019068 name: virion assembly namespace: biological_process alt_id: GO:0042963 def: "A late phase of the viral life cycle during which all the components necessary for the formation of a mature virion collect at a particular site in the cell and the basic structure of the virus particle is formed." [ISBN:0121585336] synonym: "bacteriophage assembly" NARROW [GOC:bm] synonym: "phage assembly" NARROW [GOC:bm] synonym: "viral assembly" EXACT [] synonym: "viral particle assembly" EXACT [] synonym: "virion assembly and maintenance" EXACT [GOC:bf, GOC:jl] synonym: "virion organization" EXACT [GOC:bf, GOC:jl] synonym: "virus assembly" EXACT [GOC:dph, GOC:tb] synonym: "virus particle assembly" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019069 name: viral capsid assembly namespace: biological_process def: "The assembly of a virus capsid from its protein subunits." [ISBN:0781702534, UniProtKB-KW:KW-0118] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019070 name: viral genome maturation namespace: biological_process def: "The processes involved in creating a mature, stable viral genome. Begins after genome replication with a newly synthesized nucleic acid and ends when the genome is ready to be packaged. Includes the addition of proteins to the newly synthesized genome, and DNA repair processes." [GOC:pk, PMID:21490093] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019071 name: viral DNA cleavage involved in viral genome maturation namespace: biological_process def: "The cleavage of viral DNA into singular functional units." [ISBN:0121585336] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0019070 ! viral genome maturation [Term] id: GO:0019072 name: viral genome packaging namespace: biological_process def: "The encapsulation of the viral genome within the capsid." [ISBN:0121585336] is_a: GO:0016032 ! viral process relationship: part_of GO:0019068 ! virion assembly [Term] id: GO:0019073 name: viral DNA genome packaging namespace: biological_process def: "The packing of viral DNA into a capsid." [ISBN:0781702534] is_a: GO:0019072 ! viral genome packaging [Term] id: GO:0019074 name: viral RNA genome packaging namespace: biological_process def: "The packaging of viral RNA (single-stranded or double-stranded) into a nucleocapsid." [ISBN:0781718325] is_a: GO:0019072 ! viral genome packaging [Term] id: GO:0019075 name: virus maturation namespace: biological_process def: "The refolding and structural rearrangements of virion parts to transition from the intermediate virion to the more mature virion. Maturation usually involves proteolysis events and changes in the folding of the virion proteins. Can occur inside the host cell or after release." [ISBN:0781718325] synonym: "bacteriophage maturation" NARROW [PMID:22308333] synonym: "viral maturation" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019076 name: viral release from host cell namespace: biological_process def: "The dissemination of mature viral particles from the host cell, e.g. by cell lysis or the budding of virus particles from the cell membrane." [GOC:jl] synonym: "release of virus from host" EXACT [] synonym: "viral exit" EXACT [] synonym: "viral release" EXACT [] synonym: "viral shedding" EXACT [] synonym: "virus exit from host cell" EXACT [GOC:bf, GOC:jl] xref: VZ:1076 "Virus exit from host cell" is_a: GO:0016032 ! viral process is_a: GO:0035891 ! exit from host cell relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019078 name: obsolete lytic viral budding namespace: biological_process def: "OBSOLETE. A form of viral release in which the viral particles bud out through cellular membranes, resulting in cell lysis. It is also a form of viral envelopment." [ISBN:0781702534] comment: This term was made obsolete because it does not appear to correspond to a real biological process. synonym: "lytic viral budding" EXACT [] is_obsolete: true [Term] id: GO:0019079 name: viral genome replication namespace: biological_process def: "Any process involved directly in viral genome replication, including viral nucleotide metabolism." [ISBN:0781702534] synonym: "sigma virus replication" NARROW [] synonym: "viral replication" BROAD [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019058 ! viral life cycle [Term] id: GO:0019080 name: viral gene expression namespace: biological_process def: "A process by which a viral gene is converted into a mature gene product or products (proteins or RNA). This includes viral transcription, processing to produce a mature RNA product, and viral translation." [GOC:bf, GOC:jl, ISBN:0121585336] synonym: "viral genome expression" EXACT [GOC:jl] is_a: GO:0016032 ! viral process [Term] id: GO:0019081 name: viral translation namespace: biological_process def: "A process by which viral mRNA is translated into viral protein, using the host cellular machinery." [GOC:bf, GOC:jl, ISBN:0781702534] synonym: "viral protein anabolism" EXACT [] synonym: "viral protein biosynthesis" EXACT [] synonym: "viral protein biosynthetic process" EXACT [ISBN:0781702534] synonym: "viral protein formation" EXACT [] synonym: "viral protein synthesis" EXACT [] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019082 name: viral protein processing namespace: biological_process def: "Any protein maturation process achieved by the cleavage of a peptide bond or bonds within a viral protein." [GOC:bf, GOC:jl, ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019083 name: viral transcription namespace: biological_process def: "The process by which a viral genome, or part of a viral genome, is transcribed within the host cell." [GOC:jl, ISBN:0781702534] is_a: GO:0016032 ! viral process relationship: part_of GO:0019080 ! viral gene expression [Term] id: GO:0019084 name: middle viral transcription namespace: biological_process def: "The viral transcription that takes place after early transcription in the viral life cycle, and which involves the transcription of genes required for replication." [GOC:bf, GOC:jl] synonym: "(delayed) early viral mRNA transcription" RELATED [GOC:jh2] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019085 name: early viral transcription namespace: biological_process def: "The first phase of viral transcription that occurs after entry of the virus into the host cell, but prior to viral genome replication. It involves the transcription of genes for non-structural proteins, and for lytic viruses, the early gene products are involved in establishing control over the host cell." [GOC:bf, GOC:jh2, GOC:jl] synonym: "immediate early viral mRNA transcription" RELATED [] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019086 name: late viral transcription namespace: biological_process def: "The transcription of the final group of viral genes of the viral life cycle, following middle transcription, or where middle transcription doesn't occur, following early transcription. Involves the transcription of genes encoding structural proteins." [GOC:bf, GOC:jh2, GOC:jl] synonym: "late viral mRNA transcription" RELATED [] is_a: GO:0019083 ! viral transcription [Term] id: GO:0019087 name: transformation of host cell by virus namespace: biological_process def: "Any virus-induced change in the morphological, biochemical, or growth parameters of a cell." [ISBN:0781702534] synonym: "viral transformation" EXACT [] synonym: "viral transformation of host cell" EXACT [] xref: Wikipedia:Viral_transformation is_a: GO:0019048 ! modulation by virus of host morphology or physiology [Term] id: GO:0019088 name: immortalization of host cell by virus namespace: biological_process def: "A virus-induced cellular transformation arising in immortalized cells, or cells capable of indefinite replication, due to their ability to produce their own telomerase." [ISBN:0781702534, PMID:24373315] synonym: "viral immortalization" EXACT [] is_a: GO:0019087 ! transformation of host cell by virus is_a: GO:0020021 ! immortalization of host cell [Term] id: GO:0019089 name: transmission of virus namespace: biological_process def: "The transfer of virions in order to create new infection." [ISBN:0781702534] synonym: "viral transmission" EXACT [] is_a: GO:0016032 ! viral process is_a: GO:0044007 ! dissemination or transmission of symbiont from host [Term] id: GO:0019090 name: mitochondrial rRNA export from mitochondrion namespace: biological_process def: "The process in which a rRNA, ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai, PMID:28115039] synonym: "export of mitochondrial rRNA" BROAD [] synonym: "mitochondrial rRNA export" EXACT [] synonym: "mitochondrial rRNA export from mitochondria" EXACT [] synonym: "mitochondrial rRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial rRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial rRNA, mitochondrial export" EXACT [] is_a: GO:0051029 ! rRNA transport is_a: GO:1990542 ! mitochondrial transmembrane transport [Term] id: GO:0019091 name: mitochondrial lrRNA export from mitochondrion namespace: biological_process def: "The process in which a lrRNA, large subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] synonym: "export of mitochondrial lrRNA" BROAD [] synonym: "mitochondrial lrRNA export" EXACT [] synonym: "mitochondrial lrRNA export from mitochondria" EXACT [] synonym: "mitochondrial lrRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial lrRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial lrRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019092 name: mitochondrial srRNA export from mitochondrion namespace: biological_process def: "The process in which a srRNA, small subunit ribosomal ribonucleic acid, is transported from the mitochondrial matrix into the cytosol." [GOC:ai] synonym: "export of mitochondrial srRNA" BROAD [] synonym: "mitochondrial srRNA export" EXACT [] synonym: "mitochondrial srRNA export from mitochondria" EXACT [] synonym: "mitochondrial srRNA export out of mitochondrion" EXACT [] synonym: "mitochondrial srRNA transport from mitochondrion" EXACT [] synonym: "mitochondrial srRNA, mitochondrial export" EXACT [] is_a: GO:0019090 ! mitochondrial rRNA export from mitochondrion [Term] id: GO:0019093 name: mitochondrial RNA localization namespace: biological_process def: "Any process in which mitochondrial RNA is transported to, or maintained in, a specific location." [GOC:ai] synonym: "establishment and maintenance of mitochondrial RNA localization" EXACT [] synonym: "mitochondrial RNA localisation" EXACT [GOC:mah] synonym: "mtRNA localization" EXACT [] is_a: GO:0006403 ! RNA localization [Term] id: GO:0019094 name: pole plasm mRNA localization namespace: biological_process alt_id: GO:0048120 def: "Any process in which mRNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of mRNA localization in pole plasm" EXACT [] synonym: "establishment and maintenance of pole plasm mRNA localization" EXACT [] synonym: "oocyte pole plasm mRNA localization" EXACT [] synonym: "pole granule RNA localization" BROAD [] synonym: "pole plasm mRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0060811 ! intracellular mRNA localization involved in anterior/posterior axis specification [Term] id: GO:0019095 name: pole plasm mitochondrial rRNA localization namespace: biological_process alt_id: GO:0048117 def: "Any process in which mitochondrial ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial rRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial rRNA localization" EXACT [] synonym: "pole plasm mitochondrial rRNA localisation" EXACT [GOC:mah] is_a: GO:0007316 ! pole plasm RNA localization is_a: GO:0019093 ! mitochondrial RNA localization [Term] id: GO:0019096 name: pole plasm mitochondrial lrRNA localization namespace: biological_process alt_id: GO:0048118 def: "Any process in which mitochondrial large ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial lrRNA localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial lrRNA localization" EXACT [] synonym: "pole plasm mitochondrial lrRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019097 name: pole plasm mitochondrial srRNA localization namespace: biological_process alt_id: GO:0048119 def: "Any process in which mitochondrial small ribosomal RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [ISBN:0879694238] synonym: "establishment and maintenance of mitochondrial localization in pole plasm" EXACT [] synonym: "oocyte pole plasm mitochondrial srRNA localization" EXACT [] synonym: "pole plasm mitochondrial srRNA localisation" EXACT [GOC:mah] is_a: GO:0019095 ! pole plasm mitochondrial rRNA localization [Term] id: GO:0019098 name: reproductive behavior namespace: biological_process alt_id: GO:0033057 alt_id: GO:0044704 def: "The specific behavior of an organism that is associated with reproduction." [GOC:jl, GOC:pr] synonym: "multicellular organism reproductive behavior" NARROW [] synonym: "reproductive behavior in a multicellular organism" EXACT [GOC:curators] synonym: "reproductive behaviour" EXACT [] synonym: "single-organism reproductive behavior" RELATED [] is_a: GO:0007610 ! behavior is_a: GO:0048609 ! multicellular organismal reproductive process [Term] id: GO:0019099 name: female germ-line sex determination namespace: biological_process alt_id: GO:0007544 def: "The determination of sex and sexual phenotype in a female organism's germ line." [GOC:mah] synonym: "sex determination, female germ-line determination" EXACT [] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019100 name: male germ-line sex determination namespace: biological_process def: "The determination of sex and sexual phenotype in a male organism's germ line." [GOC:mah] is_a: GO:0007542 ! primary sex determination, germ-line is_a: GO:0018992 ! germ-line sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019101 name: female somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a female organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030237 ! female sex determination [Term] id: GO:0019102 name: male somatic sex determination namespace: biological_process def: "The determination of sex and sexual phenotypes in a male organism's soma." [GOC:mah] is_a: GO:0018993 ! somatic sex determination is_a: GO:0030238 ! male sex determination [Term] id: GO:0019103 name: pyrimidine nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0019104 name: DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0008578 def: "Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] synonym: "DNA glycosylase activity" EXACT [] synonym: "endonuclease VIII activity" RELATED [] xref: EC:3.2.2 xref: reactome:R-HSA-110218 "Cleavage of uracil by TDG glycosylase" xref: reactome:R-HSA-110219 "Cleavage of thymine by TDG glycosylase" xref: reactome:R-HSA-110231 "Cleavage of uracil by MBD4 glycosylase" xref: reactome:R-HSA-110232 "Cleavage of thymine by MBD4 glycosylase" xref: reactome:R-HSA-110234 "Cleavage of ethenocytosine by TDG glycosylase" xref: reactome:R-HSA-110246 "Cleavage of adenine mispaired with 8-oxoguanine by MUTYH" xref: reactome:R-HSA-110248 "Cleavage of 3-methyladenine by MPG glycosylase" xref: reactome:R-HSA-110250 "Cleavage of ethenoadenine by MPG glycosylase" xref: reactome:R-HSA-110251 "Cleavage of hypoxanthine by MPG glycosylase" xref: reactome:R-HSA-5220959 "TDG excises 5-formylcytosine" xref: reactome:R-HSA-5221061 "TDG excises 5-carboxylcytosine" xref: reactome:R-HSA-5649658 "NEIL1 cleaves DHU from damaged DNA" xref: reactome:R-HSA-5649664 "NEIL1 cleaves FapyG from damaged DNA" xref: reactome:R-HSA-5649673 "NEIL1 cleaves FapyA from damaged DNA" xref: reactome:R-HSA-5649681 "NEIL2 cleaves 5-OHU from damaged DNA" is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140097 ! catalytic activity, acting on DNA [Term] id: GO:0019105 name: N-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] xref: EC:2.3.1 is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019107 name: myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl (CH3-[CH2]12-CO-) group to an acceptor molecule." [GOC:ai] xref: reactome:R-HSA-141367 "Myristoylation of tBID by NMT1" xref: reactome:R-HSA-162914 "Myristoylation of Nef" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0019108 name: aryl-aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic aldehyde + NAD+ + H2O = an aromatic acid + NADH + H+." [EC:1.2.1.29] synonym: "aryl-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.29] xref: EC:1.2.1.29 xref: MetaCyc:ARYL-ALDEHYDE-DEHYDROGENASE-RXN xref: UM-BBD_reactionID:r0394 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0019111 name: phenanthrol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + X-SO3(-) = HX + phenanthrylsulfate." [EC:2.8.2.-] synonym: "phenanthrol sulphotransferase activity" EXACT [] is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0019112 name: phenanthrol glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrol + glucose = phenanthryl-beta-D-glucopyranoside + H2O." [GOC:ai] is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0019113 name: limonene monooxygenase activity namespace: molecular_function def: "Catalysis of a monooxygenase reaction in which oxygen is incorporated into limonene." [GOC:mah] xref: EC:1.14.13 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019114 name: catechol dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: catechol + O2 = a muconate." [GOC:mah, MetaCyc:CATECHOL-12-DIOXYGENASE-RXN, MetaCyc:CATECHOL-23-DIOXYGENASE-RXN] xref: EC:1.13.11 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019115 name: benzaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: benzaldehyde + NAD(P)+ + H2O = benzoate + NAD(P)H + H+." [EC:1.2.1.28, EC:1.2.1.7] xref: EC:1.2.1 is_a: GO:0004030 ! aldehyde dehydrogenase [NAD(P)+] activity [Term] id: GO:0019116 name: hydroxy-nicotine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxynicotine + H2O + O2 = 1-(6-hydroxypyrid-3-yl)-4-(methylamino)butan-1-one + hydrogen peroxide." [GOC:jl, http://umbbd.ahc.umn.edu/] xref: EC:1.5.3.6 is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0019117 name: dihydroxyfluorene dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a dihydroxyfluorene + O2 = the corresponding 2-hydroxy-4-(oxo-1,3-dihydro-2H-inden-ylidene) but-2-enoic acid." [GOC:mah, UM-BBD_reactionID:r0415, UM-BBD_reactionID:r0422] xref: EC:1.13.11 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0019118 name: phenanthrene-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: a phenanthrene dioxide + H2O = a dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0535, UM-BBD_reactionID:r0536] xref: EC:3.3.2 is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0019119 name: phenanthrene-9,10-epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: phenanthrene-9,10-oxide + H2O = trans-9,10-dihydrodiolphenanthrene." [GOC:mah, UM-BBD_reactionID:r0496, UM-BBD_reactionID:r0560] is_a: GO:0019118 ! phenanthrene-epoxide hydrolase activity [Term] id: GO:0019120 name: hydrolase activity, acting on acid halide bonds, in C-halide compounds namespace: molecular_function def: "Catalysis of the hydrolysis of any acid halide bond in substances containing halogen atoms in organic linkage." [ISBN:0198506732] xref: EC:3.8.1 xref: reactome:R-HSA-9011595 "GSTZ1 dimer dehalogenates DCA to glyoxylate" is_a: GO:0016824 ! hydrolase activity, acting on acid halide bonds [Term] id: GO:0019121 name: peptidoglycan-protein cross-linking via N6-mureinyl-L-lysine namespace: biological_process def: "The process of linking a protein to peptidoglycan via the epsilon amino group of lysine to the diaminopimelic acid of the peptidoglycan." [RESID:AA0218] xref: RESID:AA0218 is_a: GO:0018104 ! peptidoglycan-protein cross-linking is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019122 name: peptidyl-D-alanine racemization namespace: biological_process def: "The formation of peptidyl-D-alanine, by either racemization or from peptidyl-L-serine." [RESID:AA0191] comment: See also the biological process terms 'peptidyl-D-alanine racemization, direct ; GO:0019916' and 'peptidyl-D-alanine racemization via peptidyl-L-serine ; GO:0019917'. synonym: "alanine racemization" BROAD [] xref: RESID:AA0191 is_a: GO:0018085 ! peptidyl-L-amino acid racemization is_a: GO:0018194 ! peptidyl-alanine modification [Term] id: GO:0019123 name: peptidyl-methionine racemization namespace: biological_process alt_id: GO:0018087 alt_id: GO:0018369 def: "The racemization of peptidyl-methionine." [RESID:AA0193] xref: RESID:AA0193 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019124 name: peptidyl-isoleucine racemization namespace: biological_process alt_id: GO:0018088 alt_id: GO:0018370 def: "The racemization of peptidyl-isoleucine." [RESID:AA0192] xref: RESID:AA0192 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019125 name: peptidyl-phenylalanine racemization namespace: biological_process alt_id: GO:0018089 alt_id: GO:0018371 def: "The racemization of peptidyl-phenylalanine." [RESID:AA0194] xref: RESID:AA0194 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019126 name: peptidyl-serine racemization namespace: biological_process alt_id: GO:0018090 alt_id: GO:0018372 def: "The racemization of peptidyl-serine." [RESID:AA0195] xref: RESID:AA0195 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019128 name: peptidyl-tryptophan racemization namespace: biological_process alt_id: GO:0018092 alt_id: GO:0018374 def: "The racemization of peptidyl-tryptophan." [RESID:AA0198] xref: RESID:AA0198 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019129 name: peptidyl-leucine racemization namespace: biological_process alt_id: GO:0018093 alt_id: GO:0018375 def: "The racemization of peptidyl-leucine." [RESID:AA0197] xref: RESID:AA0197 is_a: GO:0018085 ! peptidyl-L-amino acid racemization [Term] id: GO:0019131 name: obsolete tripeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide; requires acid pH." [EC:3.4.14.9] comment: This term was made obsolete because it represents a gene product. synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.9] synonym: "tripeptidyl-peptidase I activity" EXACT [] xref: EC:3.4.14.9 xref: MetaCyc:3.4.14.9-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0019132 name: obsolete C-terminal processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptides after specific recognition of a C-terminal tripeptide, Xaa-Yaa-Zaa, in which Xaa is preferably Ala or Leu, Yaa is preferably Ala or Tyr, and Zaa is preferably Ala. Cleavage is at a variable distance from the C-terminus; a typical cleavage is -Ala-Ala-Arg-Ala-Ala-Lys-Glu-Asn-Tyr-Ala-Leu-Ala-Ala." [EC:3.4.21.102] comment: This term was made obsolete because it represents a gene product. synonym: "C-terminal processing peptidase activity" EXACT [] synonym: "CtpA gene product (Synechocystis sp.)" RELATED [EC:3.4.21.102] synonym: "photosystem II D1 protein processing peptidase" NARROW [EC:3.4.21.102] synonym: "protease Re" RELATED [EC:3.4.21.102] synonym: "tail-specific protease activity" EXACT [EC:3.4.21.102] synonym: "Tsp protease" NARROW [EC:3.4.21.102] xref: EC:3.4.21.102 xref: MetaCyc:3.4.21.102-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0019133 name: choline monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + 2 reduced ferredoxin + O2 + 2 H+ = betaine aldehyde hydrate + 2 oxidized ferredoxin + H2O." [EC:1.14.15.7] synonym: "choline,reduced-ferredoxin:oxygen oxidoreductase activity" EXACT [EC:1.14.15.7] xref: EC:1.14.15.7 xref: MetaCyc:RXN1F-357 is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0019134 name: glucosamine-1-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucosamine 1-phosphate + acetyl-CoA = N-acetyl-alpha-D-glucosamine 1-phosphate + CoA + H(+)." [EC:2.3.1.157, RHEA:13725] synonym: "acetyl-CoA:alpha-D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] synonym: "acetyl-CoA:D-glucosamine-1-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.157] xref: EC:2.3.1.157 xref: KEGG:R05332 xref: MetaCyc:2.3.1.157-RXN xref: RHEA:13725 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0019135 name: deoxyhypusine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(4-aminobutyl)-L-lysine + donor-H2 + O2 = protein N6-((R)-4-amino-2-hydroxybutyl)-L-lysine + acceptor + H2O." [EC:1.14.99.29] synonym: "deoxyhypusine dioxygenase activity" EXACT [EC:1.14.99.29] synonym: "deoxyhypusine hydroxylase activity" EXACT [] synonym: "deoxyhypusine,hydrogen-donor:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.99.29] synonym: "DOHH activity" EXACT [EC:1.14.99.29] xref: EC:1.14.99.29 xref: MetaCyc:DEOXYHYPUSINE-MONOOXYGENASE-RXN xref: reactome:R-HSA-204662 "DOHH:Fe2+ hydroxylates Dhp-K50-EIF5A to form Hyp-K50-EIF5A" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0019136 name: deoxynucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2'-deoxynucleoside = ADP + 2'-deoxynucleoside 5'-phosphate." [EC:2.7.1.145] synonym: "ATP:deoxynucleoside 5'-phosphotransferase activity" EXACT [EC:2.7.1.145] synonym: "D. melanogaster deoxynucleoside kinase activity" EXACT [EC:2.7.1.145] synonym: "Dm-dNK" RELATED [EC:2.7.1.145] synonym: "ms-dNK" RELATED [EC:2.7.1.145] synonym: "Ms-dNK activity" RELATED [EC:2.7.1.145] synonym: "multifunctional deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multispecific deoxynucleoside kinase activity" RELATED [EC:2.7.1.145] synonym: "multisubstrate deoxyribonucleoside kinase activity" RELATED [EC:2.7.1.145] xref: EC:2.7.1.145 xref: MetaCyc:2.7.1.145-RXN is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0019137 name: thioglucosidase activity namespace: molecular_function def: "Catalysis of the reaction: a thioglucoside + H2O = a thiol + a sugar." [EC:3.2.1.147] synonym: "myrosinase activity" EXACT [] synonym: "sinigrase activity" EXACT [] synonym: "sinigrinase activity" EXACT [] synonym: "thioglucoside glucohydrolase activity" EXACT [] xref: EC:3.2.1.147 xref: MetaCyc:RXN-9946 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019139 name: cytokinin dehydrogenase activity namespace: molecular_function alt_id: GO:0046420 def: "Catalysis of the reaction: N6-dimethylallyladenine + acceptor + H2O = adenine + 3-methylbut-2-enal + reduced electron acceptor." [EC:1.5.99.12] synonym: "6-N-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "cytokinin oxidase activity" RELATED [] synonym: "N6-dimethylallyladenine:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.12] synonym: "N6-dimethylallyladenine:acceptor oxidoreductase activity" EXACT [EC:1.5.99.12] xref: EC:1.5.99.12 xref: MetaCyc:1.5.99.12-RXN xref: MetaCyc:PWY-2841 xref: RHEA:13625 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0019140 name: inositol 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + myo-inositol = ADP + 1D-myo-inositol 3-phosphate." [EC:2.7.1.64] synonym: "ATP:myo-inositol 1-phosphotransferase activity" EXACT [EC:2.7.1.64] synonym: "inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "inositol-1-kinase (phosphorylating)" EXACT [EC:2.7.1.64] synonym: "myo-inositol 1-kinase activity" RELATED [EC:2.7.1.64] synonym: "myo-inositol 3-kinase activity" EXACT [] synonym: "myoinositol kinase activity" BROAD [EC:2.7.1.64] xref: EC:2.7.1.64 xref: MetaCyc:MYO-INOSITOL-1-KINASE-RXN xref: RHEA:21804 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019141 name: 2-dehydropantolactone reductase (B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantolactone + NADP+ = 2-dehydropantolactone + NADPH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NADP+." [EC:1.1.1.214] synonym: "(R)-pantolactone:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.1.1.214] synonym: "2-dehydropantoyl-lactone reductase (B-specific) activity" EXACT [] synonym: "2-ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] synonym: "2-oxopantoyl lactone reductase" BROAD [EC:1.1.1.214] synonym: "ketopantoyl lactone reductase activity" BROAD [EC:1.1.1.214] xref: EC:1.1.1.214 xref: MetaCyc:DEHYDROPANTLACRED-RXN is_a: GO:0036441 ! 2-dehydropantolactone reductase activity [Term] id: GO:0019142 name: 2-hydroxyglutarate synthase activity namespace: molecular_function def: "Catalysis of the reaction: glyoxylate + H(2)O + propanoyl-CoA = 2-hydroxyglutarate + CoA + H(+)." [EC:2.3.3.11, RHEA:19185] comment: Note that this function was formerly EC:4.1.3.9. synonym: "2-hydroxyglutarate glyoxylate-lyase (CoA-propanoylating) activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaratic synthetase activity" EXACT [EC:2.3.3.11] synonym: "2-hydroxyglutaric synthetase activity" EXACT [EC:2.3.3.11] synonym: "alpha-hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "hydroxyglutarate synthase activity" EXACT [EC:2.3.3.11] synonym: "propanoyl-CoA:glyoxylate C-propanoyltransferase (thioester-hydrolysing, 2-carboxyethyl-forming)" EXACT [EC:2.3.3.11] xref: EC:2.3.3.11 xref: KEGG:R00932 xref: MetaCyc:HYDGLUTSYN-RXN xref: RHEA:19185 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0019143 name: 3-deoxy-manno-octulosonate-8-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-phospho-3-deoxy-D-manno-oct-2-ulosonate + H(2)O = 3-deoxy-D-manno-octulosonate + phosphate." [EC:3.1.3.45, RHEA:11500] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate 8-phosphohydrolase activity" EXACT [EC:3.1.3.45] xref: EC:3.1.3.45 xref: KEGG:R03350 xref: MetaCyc:KDO-8PPHOSPHAT-RXN xref: RHEA:11500 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019144 name: ADP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-sugar + H2O = AMP + sugar 1-phosphate." [EC:3.6.1.21] synonym: "adenosine diphosphosugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "ADP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.21] synonym: "ADPsugar pyrophosphatase activity" EXACT [EC:3.6.1.21] synonym: "nucleoside diphosphate-sugar hydrolase activity" BROAD [GOC:vw] xref: EC:3.6.1.21 xref: MetaCyc:ADPSUGPPHOSPHAT-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019145 name: aminobutyraldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanal + NAD+ + H2O = 4-aminobutanoate + NADH + 2 H+." [EC:1.2.1.19] synonym: "4-aminobutanal dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutanal:NAD+ 1-oxidoreductase activity" EXACT [EC:1.2.1.19] synonym: "4-aminobutyraldehyde dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "ABAL dehydrogenase activity" EXACT [EC:1.2.1.19] synonym: "gamma-aminobutyraldehyde dehydroganase activity" EXACT [EC:1.2.1.19] xref: EC:1.2.1.19 xref: MetaCyc:AMINOBUTDEHYDROG-RXN xref: RHEA:19105 is_a: GO:0004029 ! aldehyde dehydrogenase (NAD) activity [Term] id: GO:0019146 name: arabinose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose 5-phosphate = D-ribulose 5-phosphate + 2 H(+)." [EC:5.3.1.13, RHEA:23104] synonym: "arabinose phosphate isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.13] synonym: "D-arabinose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.13] synonym: "phosphoarabinoisomerase activity" EXACT [EC:5.3.1.13] xref: EC:5.3.1.13 xref: KEGG:R01530 xref: MetaCyc:DARAB5PISOM-RXN xref: RHEA:23104 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0019147 name: (R)-aminopropanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-1-aminopropan-2-ol + NAD(+) = aminoacetone + H(+) + NADH." [EC:1.1.1.75, RHEA:16517] synonym: "(R)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "1-aminopropan-2-ol-NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "DL-1-aminopropan-2-ol: NAD+ dehydrogenase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol-NAD/NADP oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L(+)-1-aminopropan-2-ol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.75] synonym: "L-aminopropanol dehydrogenase activity" EXACT [] xref: EC:1.1.1.75 xref: KEGG:R03759 xref: MetaCyc:AMINOPROPDEHYDROG-RXN xref: RHEA:16517 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019148 name: D-cysteine desulfhydrase activity namespace: molecular_function def: "Catalysis of the reaction: D-cysteine + H2O = sulfide + NH3 + pyruvate." [EC:4.4.1.15] synonym: "D-cysteine lyase activity" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating)" EXACT [EC:4.4.1.15] synonym: "D-cysteine sulfide-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.15] xref: EC:4.4.1.15 xref: MetaCyc:DCYSDESULF-RXN xref: RHEA:11268 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0019149 name: 3-chloro-D-alanine dehydrochlorinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloro-D-alanine + H2O = pyruvate + chloride + NH3." [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating)" EXACT [EC:4.5.1.2] synonym: "3-chloro-D-alanine chloride-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.5.1.2] synonym: "beta-chloro-D-alanine dehydrochlorinase activity" EXACT [EC:4.5.1.2] xref: EC:4.5.1.2 xref: MetaCyc:3-CHLORO-D-ALANINE-DEHYDROCHLORINASE-RXN xref: RHEA:18873 is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019150 name: D-ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose = ADP + D-ribulose 5-phosphate." [EC:2.7.1.47] synonym: "ATP:D-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.47] synonym: "D-ribulokinase (phosphorylating)" EXACT [EC:2.7.1.47] xref: EC:2.7.1.47 xref: MetaCyc:D-RIBULOKIN-RXN xref: RHEA:17601 is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0019151 name: galactose 1-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactose + NAD+ = D-galactono-1,4-lactone + NADH + H+." [EC:1.1.1.48] synonym: "beta-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose 1-dehydrogenase activity" EXACT [] synonym: "D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] synonym: "D-galactose:NAD+ 1-oxidoreductase activity" EXACT [EC:1.1.1.48] synonym: "NAD-dependent D-galactose dehydrogenase activity" EXACT [EC:1.1.1.48] xref: EC:1.1.1.48 xref: MetaCyc:GALACTODEHYDROG-RXN xref: RHEA:21296 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019152 name: acetoin dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+." [EC:1.1.1.303, EC:1.1.1.304, MetaCyc:ACETOINDEHYDROG-RXN] synonym: "diacetyl reductase activity" EXACT [] xref: EC:1.1.1.303 xref: EC:1.1.1.304 xref: KEGG:R02343 xref: MetaCyc:ACETOINDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019153 name: protein-disulfide reductase (glutathione) activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + protein-disulfide = oxidized glutathione + protein-dithiol." [EC:1.8.4.2] synonym: "glutaredoxin reductase" RELATED [] synonym: "glutathione--insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "glutathione-insulin transhydrogenase activity" EXACT [] synonym: "glutathione-protein disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "glutathione:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "GSH-insulin transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "insulin reductase activity" EXACT [EC:1.8.4.2] synonym: "protein disulfide reductase (glutathione)" EXACT [EC:1.8.4.2] synonym: "protein disulfide transhydrogenase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulfide interchange enzyme" RELATED [EC:1.8.4.2] synonym: "protein-disulfide isomerase/oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "protein-disulphide reductase (glutathione) activity" EXACT [] synonym: "reductase, protein disulfide (glutathione)" EXACT [EC:1.8.4.2] synonym: "thiol-protein disulphide oxidoreductase activity" EXACT [EC:1.8.4.2] synonym: "thiol:protein-disulfide oxidoreductase activity" EXACT [EC:1.8.4.2] xref: EC:1.8.4.2 xref: MetaCyc:PRODISULFREDUCT-RXN xref: RHEA:21064 is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0019154 name: glycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: A + glycolate = AH(2) + glyoxylate." [EC:1.1.99.14, RHEA:21264] synonym: "glycolate oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:(acceptor) 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolate:acceptor 2-oxidoreductase activity" EXACT [EC:1.1.99.14] synonym: "glycolic acid dehydrogenase activity" EXACT [EC:1.1.99.14] xref: EC:1.1.99.14 xref: KEGG:R00476 xref: MetaCyc:GLYCOLATEDEHYDRO-RXN xref: RHEA:21264 is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0019155 name: 3-(imidazol-5-yl)lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-(imidazol-5-yl)lactate + NADP+ = 3-(imidazol-5-yl)pyruvate + NADPH + H+." [EC:1.1.1.111] synonym: "(S)-3-(imidazol-5-yl)lactate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.111] synonym: "imidazol-5-yl lactate dehydrogenase activity" EXACT [EC:1.1.1.111] xref: EC:1.1.1.111 xref: MetaCyc:IMILACTDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019156 name: isoamylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages in glycogen, amylopectin and their beta-limits dextrins." [EC:3.2.1.68] synonym: "debranching enzyme activity" BROAD [EC:3.2.1.68] synonym: "glycogen alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.68] xref: EC:3.2.1.68 xref: MetaCyc:3.2.1.68-RXN xref: MetaCyc:RXN-12280 xref: MetaCyc:RXN-14380 is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0019157 name: malate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + O(2) = H(2)O(2) + oxaloacetate." [EC:1.1.3.3, RHEA:10515] synonym: "(S)-malate:oxygen oxidoreductase activity" EXACT [EC:1.1.3.3] synonym: "FAD-dependent malate oxidase activity" EXACT [EC:1.1.3.3] synonym: "malic dehydrogenase II" RELATED [EC:1.1.3.3] synonym: "malic oxidase activity" EXACT [EC:1.1.3.3] xref: EC:1.1.3.3 xref: KEGG:R00360 xref: MetaCyc:MALOX-RXN xref: RHEA:10515 is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0019158 name: mannokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-mannose = ADP + D-mannose 6-phosphate." [EC:2.7.1.7] synonym: "ATP:D-mannose 6-phosphotransferase activity" EXACT [EC:2.7.1.7] synonym: "D-fructose (D-mannose) kinase activity" EXACT [EC:2.7.1.7] synonym: "mannokinase (phosphorylating)" EXACT [EC:2.7.1.7] xref: EC:2.7.1.7 xref: MetaCyc:MANNKIN-RXN xref: RHEA:11028 is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0019159 name: nicotinamide-nucleotide amidase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinamide D-ribonucleotide + H2O = beta-nicotinate D-ribonucleotide + NH3." [EC:3.5.1.42] synonym: "nicotinamide mononucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide mononucleotide deamidase activity" EXACT [EC:3.5.1.42] synonym: "nicotinamide-D-ribonucleotide amidohydrolase activity" EXACT [EC:3.5.1.42] synonym: "NMN amidohydrolase" NARROW [] synonym: "NMN deamidase activity" EXACT [EC:3.5.1.42] xref: EC:3.5.1.42 xref: MetaCyc:NMNAMIDOHYDRO-RXN xref: RHEA:12400 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019160 name: NMN nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + nicotinamide mononucleotide = D-ribose 5-phosphate + H(+) + nicotinamide." [EC:3.2.2.14, RHEA:23140] synonym: "nicotinamide mononucleotidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide mononucleotide nucleosidase activity" EXACT [EC:3.2.2.14] synonym: "nicotinamide-nucleotide phosphoribohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMN glycohydrolase activity" EXACT [EC:3.2.2.14] synonym: "NMNase activity" EXACT [EC:3.2.2.14] synonym: "NMNGhase activity" EXACT [EC:3.2.2.14] xref: EC:3.2.2.14 xref: KEGG:R01270 xref: MetaCyc:NMNNUCLEOSID-RXN xref: RHEA:23140 is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0019161 name: diamine transaminase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha,omega-diamine + 2-oxoglutarate = an omega-aminoaldehyde + L-glutamate." [EC:2.6.1.29] synonym: "amine transaminase activity" EXACT [EC:2.6.1.29] synonym: "amine-ketoacid transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine aminotransferase activity" EXACT [] synonym: "diamine-ketoglutaric transaminase activity" EXACT [EC:2.6.1.29] synonym: "diamine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.29] xref: EC:2.6.1.29 xref: MetaCyc:DIAMTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019162 name: pyridoxamine-oxaloacetate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate + pyridoxamine = L-aspartate + pyridoxal." [EC:2.6.1.31, RHEA:10844] synonym: "pyridoxamine--oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] synonym: "pyridoxamine-oxaloacetate aminotransferase activity" EXACT [] synonym: "pyridoxamine:oxaloacetate aminotransferase activity" EXACT [EC:2.6.1.31] xref: EC:2.6.1.31 xref: KEGG:R01713 xref: MetaCyc:PYROXALTRANSAM-RXN xref: RHEA:10844 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019163 name: pyridoxamine-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + 2-oxoglutarate = pyridoxal 5'-phosphate + D-glutamate." [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine 5'-phosphate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine phosphate aminotransferase activity" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-5'-phosphate:2-oxoglutarate aminotransferase (D-glutamate-forming)" EXACT [EC:2.6.1.54] synonym: "pyridoxamine-phosphate aminotransferase activity" EXACT [] xref: EC:2.6.1.54 xref: MetaCyc:PYRDAMPTRANS-RXN xref: RHEA:15877 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019164 name: pyruvate synthase activity namespace: molecular_function alt_id: GO:0018696 def: "Catalysis of the reaction: pyruvate + CoA + 2 oxidized ferredoxin = acetyl-CoA + CO2 + 2 reduced ferredoxin + 2 H+." [KEGG:R01196] synonym: "PFOR" EXACT [] synonym: "pyruvate oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate synthetase activity" EXACT [EC:1.2.7.1] synonym: "pyruvate-ferredoxin reductase activity" EXACT [] synonym: "pyruvate:ferredoxin 2-oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.7.1] synonym: "pyruvate:ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] synonym: "pyruvic-ferredoxin oxidoreductase activity" EXACT [EC:1.2.7.1] xref: EC:1.2.7.1 xref: KEGG:R01196 xref: MetaCyc:PYRUFLAVREDUCT-RXN is_a: GO:0016625 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, iron-sulfur protein as acceptor [Term] id: GO:0019165 name: thiamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamine = ADP + 2 H(+) + thiamine phosphate." [EC:2.7.1.89, RHEA:12012] synonym: "ATP:thiamin phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "ATP:thiamine phosphotransferase activity" EXACT [EC:2.7.1.89] synonym: "thiamin kinase (phosphorylating)" EXACT [EC:2.7.1.89] synonym: "thiamin kinase activity" EXACT [EC:2.7.1.89] synonym: "thiamin phosphokinase activity" EXACT [EC:2.7.1.89] xref: EC:2.7.1.89 xref: KEGG:R02134 xref: MetaCyc:THIKIN-RXN xref: RHEA:12012 is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0019166 name: trans-2-enoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + NADP+ = trans-2,3-dehydroacyl-CoA + NADPH + H+." [EC:1.3.1.38] synonym: "acyl-CoA:NADP+ trans-2-oxidoreductase activity" EXACT [EC:1.3.1.38] synonym: "NADPH-dependent trans-2-enoyl-CoA reductase activity" EXACT [EC:1.3.1.38] synonym: "reductase, trans-enoyl coenzyme A" EXACT [EC:1.3.1.38] xref: EC:1.3.1.38 xref: MetaCyc:TRANSENOYLCOARED-RXN xref: reactome:R-HSA-6786720 "DECR2 reduces LCtE-CoA to t3enoyl-CoA" xref: reactome:R-HSA-6809810 "PECR reduces 2E-phytenoyl-CoA to phytanoyl-CoA" xref: reactome:R-HSA-8952873 "MECR dimer reduces tdec2-CoA to DEC-CoA" is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0019168 name: 2-octaprenylphenol hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octaprenylphenol + NADPH + O2 + H+ = 2-octaprenyl-6-hydroxyphenol + NADP+ + H2O." [MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN] xref: MetaCyc:2-OCTAPRENYLPHENOL-HYDROX-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019170 name: methylglyoxal reductase (NADH-dependent) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactaldehyde + NAD+ = methylglyoxal + NADH + H+." [EC:1.1.1.78] synonym: "(R)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.78] synonym: "D-lactaldehyde dehydrogenase activity" EXACT [] synonym: "methylglyoxal reductase activity" EXACT [] xref: EC:1.1.1.78 xref: MetaCyc:D-LACTALDEHYDE-DEHYDROGENASE-RXN xref: RHEA:24528 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0019171 name: 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein]." [MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN] synonym: "3-hydroxyacyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxyacyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.59 xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN xref: RHEA:13097 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0019172 name: glyoxalase III activity namespace: molecular_function def: "Catalysis of the reaction: methylglyoxal + H2O = D-lactate." [EC:4.2.1.130, GOC:mcc, http://www.brenda-enzymes.org/php/result_flat.php4?ecno=4.2.1.130, MetaCyc:GLYOXIII-RXN, PMID:21696459, PMID:7848303, RHEA:27754] comment: Note that this term was reinstated from obsolete. Also note that this enzymatic activity converts methylglyoxal to D-lactate in a single glutathione (GSH)-independent step. The other known route for this conversion is the two-step GSH-dependent pathway catalyzed by EC 4.4.1.5 (lactoylglutathione lyase) and EC 3.1.2.6 (hydroxyacylglutathione hydrolase). synonym: "(R)-lactate hydro-lyase" EXACT [] synonym: "D-lactate dehydratase" EXACT [] synonym: "glutathione-independent glyoxalase activity" RELATED [] xref: MetaCyc:GLYOXIII-RXN xref: RHEA:27754 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0019174 name: tetrahydrothiophene 1-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: tetrahydrothiophene 1-oxide + reduced acceptor = tetrahydrothiophene + acceptor." [MetaCyc:THTOREDUCT-RXN] xref: MetaCyc:THTOREDUCT-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0019176 name: dihydroneopterin monophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin monophosphate = dihydroneopterin + phosphate." [MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN] synonym: "dihydroneopterin monophosphate dephosphorylase activity" EXACT [] xref: EC:3.6.1 xref: MetaCyc:DIHYDRONEOPTERIN-MONO-P-DEPHOS-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0019177 name: dihydroneopterin triphosphate pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate." [MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN] xref: EC:3.6.1 xref: MetaCyc:H2NEOPTERINP3PYROPHOSPHOHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0019178 name: NADP phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + NADP+ = NAD+ + phosphate." [MetaCyc:NADPPHOSPHAT-RXN] xref: MetaCyc:NADPPHOSPHAT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019179 name: dTDP-4-amino-4,6-dideoxy-D-glucose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-D-glucose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-D-glucose + L-glutamate." [EC:2.6.1.33] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose aminotransferase activity" EXACT [] synonym: "dTDP-4-amino-4,6-dideoxy-D-glucose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "TDP-4-oxo-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-4,6-dideoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-amino-6-deoxyglucose aminotransferase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.33] synonym: "thymidine diphospho-4-keto-6-deoxy-D-glucose-glutamic transaminase activity" EXACT [EC:2.6.1.33] xref: EC:2.6.1.33 xref: MetaCyc:2.6.1.33-RXN xref: RHEA:19085 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019180 name: dTDP-4-amino-4,6-dideoxygalactose transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + dTDP-4-amino-4,6-dideoxy-D-galactose = L-glutamate + dTDP-4-dehydro-6-deoxy-D-galactose." [EC:2.6.1.59, RHEA:10368] synonym: "dTDP-4,6-dideoxy-D-galactose:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-4-amino-4,6-dideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] synonym: "dTDP-fucosamine aminotransferase activity" EXACT [] synonym: "thymidine diphosphate 4-keto-6-deoxy-D-glucose transaminase activity" EXACT [EC:2.6.1.59] synonym: "thymidine diphosphoaminodideoxygalactose aminotransferase activity" EXACT [EC:2.6.1.59] xref: EC:2.6.1.59 xref: KEGG:R04438 xref: MetaCyc:2.6.1.59-RXN xref: RHEA:10368 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0019181 name: halohydrin hydrogen-halide-lyase activity namespace: molecular_function def: "Catalysis of the reaction: a halohydrin = an epoxide + a hydrogen halide." [PMID:8017917] is_a: GO:0016848 ! carbon-halide lyase activity [Term] id: GO:0019182 name: histamine-gated chloride channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when histamine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022835 ! transmitter-gated channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0019183 name: histamine-gated chloride channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which chloride ions may pass in response to histamine binding to the channel complex or one of its constituent parts." [GOC:mah] is_a: GO:0034707 ! chloride channel complex is_a: GO:0098878 ! neurotransmitter receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0019184 name: nonribosomal peptide biosynthetic process namespace: biological_process def: "The biosynthetic process in which peptide bond formation occurs in the absence of the translational machinery. Examples include the synthesis of antibiotic peptides, and glutathione." [ISBN:0198506732] synonym: "non-ribosomal peptide biosynthesis" EXACT [] synonym: "non-ribosomal peptide biosynthetic process" EXACT [] synonym: "non-ribosomal peptide formation" EXACT [] synonym: "non-ribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide anabolism" EXACT [] synonym: "nonribosomal peptide biosynthesis" EXACT [] synonym: "nonribosomal peptide formation" EXACT [] synonym: "nonribosomal peptide synthesis" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0019185 name: snRNA-activating protein complex namespace: cellular_component def: "A protein complex that recognizes the proximal sequence element of RNA polymerase II and III snRNA promoters." [PMID:7715707, PMID:9003788] synonym: "SNAPc" EXACT [] is_a: GO:0044798 ! nuclear transcription factor complex [Term] id: GO:0019186 name: acyl-CoA N-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group from acyl-CoA to a nitrogen atom on an acceptor molecule." [GOC:mah] xref: EC:2.3.1 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0019187 name: beta-1,4-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage." [GOC:mcc, PMID:8166646] is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0019191 name: cellobiose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019190 def: "Enables the transfer of cellobiose from one side of a membrane to the other. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "cellobiose permease activity" EXACT [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity [Term] id: GO:0019194 name: sorbose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019193 def: "Enables the transfer of sorbose from one side of a membrane to the other. Sorbose is the ketohexose xylo-2-hexulose; L-sorbose is formed by bacterial oxidation of sorbitol. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose porter activity" EXACT [] is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0019196 name: galactosamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0019195 def: "Enables the transfer of galactosamine from one side of a membrane to the other. Galactosamine is an aminodeoxysugar; D-galactosamine is a constituent of some glycolipids and glycosaminoglycans, commonly as its N-acetyl derivative." [GOC:mtg_transport, ISBN:0198506732, ISBN:0815340729] synonym: "galactosamine porter activity" EXACT [] is_a: GO:1901505 ! carbohydrate derivative transmembrane transporter activity [Term] id: GO:0019197 name: phosphoenolpyruvate-dependent sugar phosphotransferase complex namespace: cellular_component def: "Includes phosphoenolpyruvate-protein phosphatase (enzyme I of the phosphotransferase system) and protein-N(PI)-phosphohistidine-sugar phosphotransferase (enzyme II of the phosphotransferase system)." [GOC:ma] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0019198 name: transmembrane receptor protein phosphatase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate." [GOC:hjd] xref: EC:3.1.3 is_a: GO:0004721 ! phosphoprotein phosphatase activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019199 name: transmembrane receptor protein kinase activity namespace: molecular_function def: "Combining with a signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: a protein + ATP = a phosphoprotein + ADP." [GOC:mah] xref: EC:2.7.11 xref: reactome:R-HSA-8983059 "STAT3 is phosphorylated by TSLP:IL7R:CRLF2:STAT3 complex" xref: reactome:R-HSA-8983063 "JAK3 in IL7:p-Y449-IL7R:JAK1:IL2RG:JAK3 is phosphorylated" is_a: GO:0004672 ! protein kinase activity is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019200 name: carbohydrate kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a carbohydrate substrate molecule." [GOC:jl] xref: reactome:R-HSA-8931653 "POMK 6-phosphorylates Mannose in GalNAc-GlcNAc-Man-DAG1" is_a: GO:0016301 ! kinase activity [Term] id: GO:0019202 name: amino acid kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to an amino acid substrate." [GOC:jl] is_a: GO:0016301 ! kinase activity [Term] id: GO:0019203 name: carbohydrate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: carbohydrate phosphate + H2O = carbohydrate + phosphate." [GOC:mah] xref: reactome:R-HSA-3781011 "EPM2A dimer dephosphorylates phosphoglycogen-GYG2" xref: reactome:R-HSA-3781018 "EPM2A dimer dephosphorylates phosphoglycogen-GYG1" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0019204 name: obsolete nucleotide phosphatase activity namespace: molecular_function def: "OBSOLETE: Catalysis of the reaction: phosphopolynucleotide + H2O = polynucleotide + phosphate." [GOC:mah] comment: This term was defined to cover phosphatase activity against polynucleotides, but had subclasses and annotations for phosphatase activity against free nucleotides. It has therefore been split. Use GO:0098519 (nucleotide phosphatase activity, acting against free nucleotides) or GO:0098518 (polynucleotide phosphatase activity). synonym: "nucleotide phosphatase activity" EXACT [] is_obsolete: true consider: GO:0098518 consider: GO:0098519 [Term] id: GO:0019205 name: nucleobase-containing compound kinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP or GTP, to a nucleobase, nucleoside, nucleotide or polynucleotide substrate." [GOC:jl] synonym: "nucleobase, nucleoside, nucleotide kinase activity" RELATED [GOC:dph, GOC:tb] is_a: GO:0016301 ! kinase activity [Term] id: GO:0019206 name: nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside = ADP + nucleoside monophosphate." [GOC:ai] xref: reactome:R-HSA-109671 "deoxyadenosine or deoxyguanosine + ATP => dAMP or dGMP + ADP (DCK)" xref: reactome:R-HSA-109759 "deoxycytidine, thymidine, or deoxyuridine + ATP => dCMP, TMP, or dUMP + ADP [TK2]" xref: reactome:R-HSA-109903 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK2]" xref: reactome:R-HSA-110137 "(d)ADP or (d)CDP + ADP <=> (d)AMP or (d)CMP + ATP" xref: reactome:R-HSA-110138 "AK5,7,8,9 phosphorylates (d)NMPs to (d)NDPs" xref: reactome:R-HSA-73598 "(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)" xref: reactome:R-HSA-73599 "cytidine or uridine + ATP => CMP or UMP + ADP [UCK1]" xref: reactome:R-HSA-73632 "thymidine + ATP => TMP (deoxythymidine 5'-monophosphate) + ADP [TK1]" xref: reactome:R-HSA-74207 "dA, dG, or dI + ATP => dAMP, dGMP, or dIMP + ADP (DGUOK)" is_a: GO:0019205 ! nucleobase-containing compound kinase activity [Term] id: GO:0019207 name: kinase regulator activity namespace: molecular_function def: "Modulates the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0019208 name: phosphatase regulator activity namespace: molecular_function def: "Modulates the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0019209 name: kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019210 name: kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a kinase, an enzyme which catalyzes of the transfer of a phosphate group, usually from ATP, to a substrate molecule." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019211 name: phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019212 name: phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a substrate molecule." [GOC:ai] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019213 name: deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule." [GOC:jl] subset: goslim_pir xref: reactome:R-HSA-5689000 "AADAC deacetylates PHEN" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019214 name: obsolete surfactant activity namespace: molecular_function def: "OBSOLETE. The action of reducing the surface tension of a liquid." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it represents involvement in a process. synonym: "surfactant activity" EXACT [] is_obsolete: true consider: GO:0050828 [Term] id: GO:0019215 name: intermediate filament binding namespace: molecular_function def: "Interacting selectively and non-covalently with an intermediate filament, a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of higher eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space." [ISBN:0198506732] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019216 name: regulation of lipid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids." [GOC:go_curators] synonym: "regulation of lipid metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006629 ! lipid metabolic process [Term] id: GO:0019217 name: regulation of fatty acid metabolic process namespace: biological_process alt_id: GO:0006632 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving fatty acids." [GOC:go_curators] synonym: "regulation of fatty acid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0006631 ! fatty acid metabolic process [Term] id: GO:0019218 name: regulation of steroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving steroids." [GOC:go_curators] synonym: "regulation of steroid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process relationship: regulates GO:0008202 ! steroid metabolic process [Term] id: GO:0019219 name: regulation of nucleobase-containing compound metabolic process namespace: biological_process def: "Any cellular process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:go_curators] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" RELATED [GOC:dph, GOC:tb] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0006139 ! nucleobase-containing compound metabolic process [Term] id: GO:0019220 name: regulation of phosphate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving phosphates." [GOC:go_curators] synonym: "regulation of phosphate metabolism" EXACT [] is_a: GO:0051174 ! regulation of phosphorus metabolic process relationship: regulates GO:0006796 ! phosphate-containing compound metabolic process [Term] id: GO:0019221 name: cytokine-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a cytokine to a receptor on the surface of a cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mah, GOC:signaling, PMID:19295629] synonym: "cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "cytokine mediated signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: part_of GO:0071345 ! cellular response to cytokine stimulus [Term] id: GO:0019222 name: regulation of metabolic process namespace: biological_process alt_id: GO:0044246 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: goslim_metagenomics synonym: "regulation of metabolism" EXACT [] synonym: "regulation of multicellular organismal metabolic process" NARROW [] synonym: "regulation of organismal metabolic process" NARROW [GOC:tb] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0008152 ! metabolic process [Term] id: GO:0019226 name: transmission of nerve impulse namespace: biological_process def: "The neurological system process in which a signal is transmitted through the nervous system by a combination of action potential propagation and synaptic transmission." [GOC:curators, ISBN:0815316194] synonym: "conduction of nerve impulse" EXACT [GOC:dph] synonym: "signal transmission along a neuron" EXACT [] is_a: GO:0035637 ! multicellular organismal signaling is_a: GO:0050877 ! nervous system process relationship: part_of GO:0007154 ! cell communication [Term] id: GO:0019227 name: neuronal action potential propagation namespace: biological_process def: "The propagation of an action potential along an axon, away from the soma." [GOC:isa_complete] is_a: GO:0050877 ! nervous system process is_a: GO:0098870 ! action potential propagation relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019228 name: neuronal action potential namespace: biological_process def: "An action potential that occurs in a neuron." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "generation of action potential" RELATED [GOC:dph, GOC:tb] is_a: GO:0001508 ! action potential relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0019229 name: regulation of vasoconstriction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels." [GOC:jl] is_a: GO:0097746 ! regulation of blood vessel diameter is_a: GO:1903522 ! regulation of blood circulation relationship: regulates GO:0042310 ! vasoconstriction [Term] id: GO:0019230 name: proprioception namespace: biological_process def: "The series of events by which an organism senses the position, location, orientation, and movement of the body and its parts. Proprioception is mediated by proprioceptors, sensory nerve terminals found in muscles, tendons, and joint capsules, which give information concerning movements and position of the body. The receptors in the labyrinth are sometimes also considered proprioceptors." [http://www.onelook.com/, ISBN:072168677X] xref: Wikipedia:Proprioception is_a: GO:0007600 ! sensory perception relationship: part_of GO:0050884 ! neuromuscular process controlling posture [Term] id: GO:0019231 name: perception of static position namespace: biological_process def: "The perception of the orientation of different parts of the body with respect to one another." [ISBN:072168677X] is_a: GO:0019230 ! proprioception [Term] id: GO:0019232 name: perception of rate of movement namespace: biological_process def: "The series of events by which an organism senses the speed and direction of movement of the body and its parts." [GOC:mah] synonym: "kinesthesia" EXACT [] is_a: GO:0019230 ! proprioception [Term] id: GO:0019233 name: sensory perception of pain namespace: biological_process def: "The series of events required for an organism to receive a painful stimulus, convert it to a molecular signal, and recognize and characterize the signal. Pain is medically defined as the physical sensation of discomfort or distress caused by injury or illness, so can hence be described as a harmful stimulus which signals current (or impending) tissue damage. Pain may come from extremes of temperature, mechanical damage, electricity or from noxious chemical substances. This is a neurological process." [http://www.onelook.com/] synonym: "nociception" EXACT [] synonym: "perception of physiological pain" NARROW [] xref: Wikipedia:Nociception is_a: GO:0007600 ! sensory perception [Term] id: GO:0019234 name: sensory perception of fast pain namespace: biological_process def: "The series of events required for an organism to receive a fast pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Fast pain is often subjectively described as a sharp or stabbing pain; in humans, the signals from a fast pain stimulus are perceived and relayed along myelinated A-delta fibers to the central nervous system, reaching their target in about 0.1 seconds." [http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019235 name: sensory perception of slow pain namespace: biological_process def: "The series of events required for an organism to receive a slow pain stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. Slow pain is often subjectively described as an aching or throbbing pain; in humans, the signals from a slow pain stimulus are perceived and relayed along unmyelinated C fibers to the central nervous system, reaching their target in about 1 second. Slow pain is often associated with tissue destruction." [http://www.people.vcu.edu/~mikuleck/ssspain/, http://www.spine-health.com/] is_a: GO:0019233 ! sensory perception of pain [Term] id: GO:0019236 name: response to pheromone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus." [GOC:jl] synonym: "pheromone response" EXACT [] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0019237 name: centromeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a centromere, a region of chromosome where the spindle fibers attach during mitosis and meiosis." [GOC:jl, SO:0000577] synonym: "centromere binding" EXACT [] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0019238 name: cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a cyclic amidine, a compound of the form R-C(=NH)-NH2, in a reaction that involves the opening of a ring." [GOC:mah] is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines [Term] id: GO:0019239 name: deaminase activity namespace: molecular_function def: "Catalysis of the removal of an amino group from a substrate, producing ammonia (NH3)." [GOC:jl] subset: goslim_pir xref: reactome:R-HSA-9014641 "HRSP12 deaminates 2AA to 2OBUTA" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0019240 name: citrulline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline anabolism" EXACT [] synonym: "citrulline biosynthesis" EXACT [] synonym: "citrulline formation" EXACT [] synonym: "citrulline synthesis" EXACT [] xref: MetaCyc:CITRULBIO-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019241 name: citrulline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732] synonym: "citrulline breakdown" EXACT [] synonym: "citrulline catabolism" EXACT [] synonym: "citrulline degradation" EXACT [] xref: MetaCyc:CITRULLINE-DEG-PWY is_a: GO:0000052 ! citrulline metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019242 name: methylglyoxal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai] synonym: "methylglyoxal anabolism" EXACT [] synonym: "methylglyoxal biosynthesis" EXACT [] synonym: "methylglyoxal formation" EXACT [] synonym: "methylglyoxal synthesis" EXACT [] is_a: GO:0009438 ! methylglyoxal metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0019243 name: methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step." [GOC:ai, GOC:dph, PMID:2198020] synonym: "D-lactate biosynthesis from methylglyoxal" BROAD [] synonym: "D-lactate biosynthetic process from methylglyoxal" BROAD [] synonym: "glyoxalase system" RELATED [] synonym: "methylglyoxal breakdown to D-lactate" BROAD [] synonym: "methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione" EXACT [] synonym: "methylglyoxal degradation to D-lactate" BROAD [] synonym: "methylglyoxal detoxification" RELATED [] xref: MetaCyc:PWY-5386 is_a: GO:0061727 ! methylglyoxal catabolic process to lactate [Term] id: GO:0019244 name: lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "lactate anabolism from pyruvate" EXACT [] synonym: "lactate formation from pyruvate" EXACT [] synonym: "lactate synthesis from pyruvate" EXACT [] synonym: "pyruvate fermentation to lactate" EXACT [] xref: Reactome:R-HSA-71849.1 is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019249 ! lactate biosynthetic process [Term] id: GO:0019245 name: D(-)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D(-)-lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "D(-)-lactate anabolism from pyruvate" EXACT [] synonym: "D(-)-lactate formation from pyruvate" EXACT [] synonym: "D(-)-lactate synthesis from pyruvate" EXACT [] is_a: GO:0019244 ! lactate biosynthetic process from pyruvate [Term] id: GO:0019246 name: L(+)-lactate biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L(+)-lactate from other compounds, including pyruvate." [GOC:go_curators] synonym: "L(+)-lactate anabolism from pyruvate" EXACT [] synonym: "L(+)-lactate formation from pyruvate" EXACT [] synonym: "L(+)-lactate synthesis from pyruvate" EXACT [] synonym: "S-lactate biosynthetic process from pyruvate" EXACT [] xref: MetaCyc:PWY-5481 is_a: GO:0019244 ! lactate biosynthetic process from pyruvate [Term] id: GO:0019247 name: lactate racemization namespace: biological_process def: "Partial conversion of one lactate enantiomer into another so that the specific optical rotation is decreased, or even reduced to zero, in the resulting mixture." [GOC:curators, PMID:16166538] is_a: GO:0006089 ! lactate metabolic process [Term] id: GO:0019248 name: D-lactate biosynthetic process from methylglyoxal via (R)-lactaldehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-lactate from methylglyoxal, via the intermediate (R)-lactaldehyde." [GOC:dph, GOC:go_curators, MetaCyc:MGLDLCTANA-PWY] synonym: "D-lactate anabolism from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate formation from methylglyoxal via (R)-lactaldehyde" EXACT [] synonym: "D-lactate synthesis from methylglyoxal via (R)-lactaldehyde" EXACT [] xref: MetaCyc:MGLDLCTANA-PWY is_a: GO:0019249 ! lactate biosynthetic process is_a: GO:0061727 ! methylglyoxal catabolic process to lactate [Term] id: GO:0019249 name: lactate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactate, the anion of lactic acid." [GOC:go_curators] synonym: "lactate anabolism" EXACT [] synonym: "lactate biosynthesis" EXACT [] synonym: "lactate formation" EXACT [] synonym: "lactate synthesis" EXACT [] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901617 ! organic hydroxy compound biosynthetic process [Term] id: GO:0019250 name: aerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the presence of oxygen." [GOC:go_curators] synonym: "aerobic cobalamin anabolism" EXACT [] synonym: "aerobic cobalamin biosynthesis" EXACT [] synonym: "aerobic cobalamin formation" EXACT [] synonym: "aerobic cobalamin synthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthesis" EXACT [] synonym: "aerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, aerobic" EXACT [] synonym: "cobalamin biosynthetic process, aerobic" EXACT [] synonym: "vitamin B12 biosynthesis, aerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, aerobic" EXACT [] xref: MetaCyc:P381-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019251 name: anaerobic cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12) in the absence of oxygen." [GOC:go_curators] synonym: "anaerobic cobalamin anabolism" EXACT [] synonym: "anaerobic cobalamin biosynthesis" EXACT [] synonym: "anaerobic cobalamin formation" EXACT [] synonym: "anaerobic cobalamin synthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthesis" EXACT [] synonym: "anaerobic vitamin B12 biosynthetic process" EXACT [] synonym: "cobalamin biosynthesis, anaerobic" EXACT [] synonym: "cobalamin biosynthetic process, anaerobic" EXACT [] synonym: "vitamin B12 biosynthesis, anaerobic" EXACT [] synonym: "vitamin B12 biosynthetic process, anaerobic" EXACT [] xref: MetaCyc:COBALSYN-PWY is_a: GO:0009236 ! cobalamin biosynthetic process [Term] id: GO:0019252 name: starch biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of starch, the most important reserve polysaccharide in plants." [GOC:ai] synonym: "starch anabolism" EXACT [] synonym: "starch biosynthesis" EXACT [] synonym: "starch formation" EXACT [] synonym: "starch synthesis" EXACT [] xref: MetaCyc:PWY-622 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0019253 name: reductive pentose-phosphate cycle namespace: biological_process def: "The fixation of carbon dioxide (CO2) as glucose in the chloroplasts of C3 plants; uses ATP and NADPH formed in the light reactions of photosynthesis; carbon dioxide reacts with ribulose 1,5-bisphosphate (catalyzed by the function of ribulose-bisphosphate carboxylase) to yield two molecules of 3-phosphoglycerate; these are then phosphorylated by ATP to 1,3-bisphosphateglyceraldehyde which, in turn, is then reduced by NADPH to glyceraldehyde 3-phosphate. The glyceraldehyde 3-phosphate is converted to fructose 5-phosphate and ribulose 5-phosphate by aldolase and other enzymes; the ribulose 5-phosphate is phosphorylated by ATP to ribulose 1,5-bisphosphate." [ISBN:0198547684] comment: See also the molecular function term 'ribulose-bisphosphate carboxylase activity ; GO:0016984'. synonym: "C3 photosynthesis" NARROW [] synonym: "Calvin cycle" NARROW [] xref: MetaCyc:CALVIN-PWY is_a: GO:0019685 ! photosynthesis, dark reaction relationship: part_of GO:0015977 ! carbon fixation [Term] id: GO:0019254 name: carnitine metabolic process, CoA-linked namespace: biological_process def: "The chemical reactions and pathways involving carnitine, where metabolism is linked to CoA." [GOC:go_curators] synonym: "carnitine metabolism, CoA-linked" EXACT [] xref: MetaCyc:CARNMET-PWY is_a: GO:0009437 ! carnitine metabolic process [Term] id: GO:0019255 name: glucose 1-phosphate metabolic process namespace: biological_process alt_id: GO:0006008 def: "The chemical reactions and pathways involving glucose 1-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-1." [GOC:ai] synonym: "glucose 1-phosphate metabolism" EXACT [] synonym: "glucose 1-phosphate utilization" RELATED [GOC:mah] xref: MetaCyc:GLUCOSE1PMETAB-PWY is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019256 name: acrylonitrile catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acrylonitrile, a colorless, volatile liquid with a pungent odor. Acrylonitrile is used in the production of acrylic fibers, plastics, and synthetic rubbers." [GOC:ai] synonym: "acrylonitrile breakdown" EXACT [] synonym: "acrylonitrile catabolism" EXACT [] synonym: "acrylonitrile degradation" EXACT [] xref: MetaCyc:P344-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018865 ! acrylonitrile metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0050899 ! nitrile catabolic process [Term] id: GO:0019257 name: 4-nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-nitrotoluene, 1-methyl-4-nitrobenzene. It is a light yellow liquid with a weak aromatic odor." [GOC:ai] synonym: "4-nitrotoluene metabolism" EXACT [] synonym: "4NT metabolic process" EXACT [] synonym: "4NT metabolism" EXACT [] is_a: GO:0019326 ! nitrotoluene metabolic process [Term] id: GO:0019258 name: 4-nitrotoluene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-nitrotoluene, 1-methyl-4-nitrobenzene." [GOC:ai] synonym: "4-nitrotoluene breakdown" EXACT [] synonym: "4-nitrotoluene catabolism" EXACT [] synonym: "4-nitrotoluene degradation" EXACT [] synonym: "4NT catabolic process" EXACT [] synonym: "4NT catabolism" EXACT [] xref: MetaCyc:P421-PWY is_a: GO:0019257 ! 4-nitrotoluene metabolic process is_a: GO:0046263 ! nitrotoluene catabolic process [Term] id: GO:0019260 name: 1,2-dichloroethane catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,2-dichloroethane, a major commodity chemical used, for example, in the manufacture of vinyl chloride." [GOC:go_curators] synonym: "1,2-dichloroethane breakdown" EXACT [] synonym: "1,2-dichloroethane catabolism" EXACT [] synonym: "1,2-dichloroethane degradation" EXACT [] xref: MetaCyc:12DICHLORETHDEG-PWY is_a: GO:0018899 ! 1,2-dichloroethane metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019261 name: 1,4-dichlorobenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 1,4-dichlorobenzene (p-dichlorobenzene or paramoth), a derivative of benzene with two chlorine atoms attached at opposite positions on the ring." [GOC:ai] synonym: "1,4-dichlorobenzene breakdown" EXACT [] synonym: "1,4-dichlorobenzene catabolism" EXACT [] synonym: "1,4-dichlorobenzene degradation" EXACT [] xref: MetaCyc:14DICHLORBENZDEG-PWY is_a: GO:0018912 ! 1,4-dichlorobenzene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019262 name: N-acetylneuraminate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732] synonym: "N-acetylneuraminate breakdown" EXACT [] synonym: "N-acetylneuraminate catabolism" EXACT [] synonym: "N-acetylneuraminate degradation" EXACT [] xref: MetaCyc:P441-PWY is_a: GO:0006054 ! N-acetylneuraminate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046348 ! amino sugar catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019263 name: adamantanone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adamantanone, tricyclo(3.3.1.13,7)decanone, a white crystalline solid used as an intermediate for microelectronics in the production of photoresists." [GOC:ai] synonym: "adamantanone breakdown" EXACT [] synonym: "adamantanone catabolism" EXACT [] synonym: "adamantanone degradation" EXACT [] xref: MetaCyc:P481-PWY is_a: GO:0018866 ! adamantanone metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019264 name: glycine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine from other compounds, including serine." [GOC:go_curators] synonym: "glycine anabolism from serine" EXACT [] synonym: "glycine formation from serine" EXACT [] synonym: "glycine synthesis from serine" EXACT [] xref: MetaCyc:GLYSYN-PWY is_a: GO:0006545 ! glycine biosynthetic process is_a: GO:0006563 ! L-serine metabolic process [Term] id: GO:0019265 name: glycine biosynthetic process, by transamination of glyoxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine by the transamination of glyoxylate." [GOC:go_curators] synonym: "glycine anabolism, by transamination of glyoxylate" EXACT [] synonym: "glycine formation, by transamination of glyoxylate" EXACT [] synonym: "glycine synthesis, by transamination of glyoxylate" EXACT [] is_a: GO:0006545 ! glycine biosynthetic process [Term] id: GO:0019266 name: asparagine biosynthetic process from oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including oxaloacetate." [GOC:go_curators] synonym: "asparagine anabolism from oxaloacetate" EXACT [] synonym: "asparagine formation from oxaloacetate" EXACT [] synonym: "asparagine synthesis from oxaloacetate" EXACT [] xref: MetaCyc:ASPARAGINE-BIOSYNTHESIS is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019267 name: asparagine biosynthetic process from cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine from other compounds, including cysteine." [GOC:go_curators] synonym: "asparagine anabolism from cysteine" EXACT [] synonym: "asparagine formation from cysteine" EXACT [] synonym: "asparagine synthesis from cysteine" EXACT [] xref: MetaCyc:ASPSYNII-PWY is_a: GO:0006529 ! asparagine biosynthetic process is_a: GO:0006534 ! cysteine metabolic process [Term] id: GO:0019268 name: obsolete glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate dehydrogenase (NADP+)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function. synonym: "glutamate anabolism, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate formation, using glutamate dehydrogenase (NAD(P)+)" EXACT [] synonym: "glutamate synthesis, using glutamate dehydrogenase (NAD(P)+)" EXACT [] is_obsolete: true consider: GO:0004353 consider: GO:0006537 [Term] id: GO:0019269 name: obsolete glutamate biosynthetic process, using glutamate synthase (NADPH) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, catalyzed by the enzyme glutamate synthase (NADPH)." [GOC:go_curators] comment: This term was made obsolete because it refers to a molecular function. synonym: "glutamate anabolism, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate formation, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamate synthesis, using glutamate synthase (NADPH)" EXACT [] is_obsolete: true consider: GO:0004355 consider: GO:0006537 [Term] id: GO:0019270 name: aerobactin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aerobactin (C22H36N4O13), a hydroxamate iron transport compound. It is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai] synonym: "aerobactin anabolism" EXACT [] synonym: "aerobactin biosynthesis" EXACT [] synonym: "aerobactin formation" EXACT [] synonym: "aerobactin synthesis" EXACT [] xref: MetaCyc:AEROBACTINSYN-PWY is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0046442 ! aerobactin metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process [Term] id: GO:0019271 name: aerobactin transport namespace: biological_process def: "The directed movement of the hydroxamate iron transport compound aerobactin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Aerobactin (C22H36N4O13) is a conjugate of 6-(N-acetyl-N-hydroxylamine)-2-aminohexanoic acid and citric acid." [GOC:ai, PMID:23192658] is_a: GO:0006842 ! tricarboxylic acid transport is_a: GO:0015891 ! siderophore transport is_a: GO:0072337 ! modified amino acid transport [Term] id: GO:0019272 name: L-alanine biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine from other compounds, including pyruvate." [GOC:go_curators] synonym: "L-alanine anabolism from pyruvate" EXACT [] synonym: "L-alanine formation from pyruvate" EXACT [] synonym: "L-alanine synthesis from pyruvate" EXACT [] xref: MetaCyc:ALANINE-SYN2-PWY xref: MetaCyc:ALANINE-VALINESYN-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019273 name: L-alanine biosynthetic process via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-alanine, via the intermediate ornithine." [GOC:go_curators] synonym: "L-alanine anabolism via ornithine" EXACT [] synonym: "L-alanine formation via ornithine" EXACT [] synonym: "L-alanine synthesis via ornithine" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0042852 ! L-alanine biosynthetic process [Term] id: GO:0019276 name: UDP-N-acetylgalactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019277 name: UDP-N-acetylgalactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine anabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylgalactosamine formation" EXACT [] synonym: "UDP-N-acetylgalactosamine synthesis" EXACT [] xref: MetaCyc:UDPNACETYLGALSYN-PWY is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0019278 name: UDP-N-acetylgalactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylgalactosamine, a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] synonym: "UDP-N-acetylgalactosamine breakdown" EXACT [] synonym: "UDP-N-acetylgalactosamine catabolism" EXACT [] synonym: "UDP-N-acetylgalactosamine degradation" EXACT [] is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0019276 ! UDP-N-acetylgalactosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0019279 name: L-methionine biosynthetic process from L-homoserine via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including L-homoserine, via the intermediate cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from L-homoserine via cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from L-homoserine via cystathionine" EXACT [GOC:mah] xref: MetaCyc:HOMOSER-METSYN-PWY is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019280 name: L-methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine from other compounds, including homoserine, via the intermediates O-acetyl-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-acetyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:HSERMETANA-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019281 name: L-methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including homoserine, via the intermediates O-succinyl-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from homoserine via O-succinyl-L-homoserine and cystathionine" EXACT [GOC:mah] xref: MetaCyc:MET-SAM-PWY is_a: GO:0019279 ! L-methionine biosynthetic process from L-homoserine via cystathionine [Term] id: GO:0019283 name: L-methionine biosynthetic process from O-phospho-L-homoserine and cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from other compounds, including O-phospho-L-homoserine and cystathionine." [GOC:go_curators] synonym: "L-methionine anabolism from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine formation from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] synonym: "methionine biosynthetic process from O-phospho-L-homoserine and cystathionine" EXACT [GOC:mah] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0071266 ! 'de novo' L-methionine biosynthetic process [Term] id: GO:0019284 name: L-methionine salvage from S-adenosylmethionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methionine from S-adenosylmethionine." [GOC:go_curators, GOC:vw] synonym: "L-methionine formation from S-adenosylmethionine" EXACT [GOC:mah] synonym: "L-methionine synthesis from S-adenosylmethionine" EXACT [GOC:mah] is_a: GO:0071267 ! L-methionine salvage relationship: part_of GO:0033353 ! S-adenosylmethionine cycle [Term] id: GO:0019285 name: glycine betaine biosynthetic process from choline namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of betaine (N-trimethylglycine) from the oxidation of choline." [GOC:jl] synonym: "choline oxidation" EXACT [GOC:dph, PMID:23563483] synonym: "glycine betaine anabolism from choline" EXACT [] synonym: "glycine betaine formation from choline" EXACT [] synonym: "glycine betaine synthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthesis from choline" EXACT [] synonym: "N-trimethylglycine biosynthetic process from choline" EXACT [] xref: MetaCyc:BETSYN-PWY xref: MetaCyc:CHOLINE-BETAINE-ANA-PWY xref: MetaCyc:P542-PWY is_a: GO:0019695 ! choline metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019286 name: glycine betaine biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine from other compounds, including glycine." [GOC:go_curators] synonym: "glycine betaine anabolism from glycine" EXACT [] synonym: "glycine betaine formation from glycine" EXACT [] synonym: "glycine betaine synthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthesis from glycine" EXACT [] synonym: "N-trimethylglycine biosynthetic process from glycine" EXACT [] xref: MetaCyc:P541-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0031456 ! glycine betaine biosynthetic process [Term] id: GO:0019287 name: isopentenyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, via the intermediate mevalonate. This pathway converts acetate, in the form of acetyl-CoA, to isopentenyl diphosphate (IPP), the fundamental unit in isoprenoid biosynthesis, through a series of mevalonate intermediates." [GOC:go_curators, MetaCyc:PWY-922] synonym: "Ac-MVA pathway" EXACT [PMID:14517367] synonym: "acetate-mevalonate pathway" EXACT [PMID:14517367] synonym: "isopentenyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process via mevalonate" EXACT [GOC:pr] synonym: "isopentenyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate pathway" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process [Term] id: GO:0019288 name: isopentenyl diphosphate biosynthetic process, methylerythritol 4-phosphate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate by the mevalonate-independent pathway. Isopentenyl diphosphate (IPP) is the fundamental unit in isoprenoid biosynthesis and is biosynthesized from pyruvate and glyceraldehyde 3-phosphate via intermediates, including 1-deoxy-D-xylulose 5-phosphate." [GOC:go_curators, MetaCyc:NONMEVIPP-PWY, PMID:18948055] synonym: "isopentenyl diphosphate anabolism, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthesis, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process via 1-deoxy-D-xylulose 5-phosphate" EXACT [GOC:pr] synonym: "isopentenyl diphosphate biosynthetic process, MEP pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate biosynthetic process, non-mevalonate pathway" EXACT [] synonym: "isopentenyl diphosphate formation, mevalonate-independent pathway" EXACT [] synonym: "isopentenyl diphosphate synthesis, mevalonate-independent pathway" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthesis" EXACT [] synonym: "mevalonate-independent isopentenyl diphosphate biosynthetic process" EXACT [] synonym: "non-MVA pathway" EXACT [] xref: MetaCyc:NONMEVIPP-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0009240 ! isopentenyl diphosphate biosynthetic process is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process [Term] id: GO:0019289 name: rhizobactin 1021 biosynthetic process namespace: biological_process alt_id: GO:0031193 alt_id: GO:0031194 def: "The chemical reactions and pathways resulting in the formation of rhizobactin 1021, (E)-4-((3-(acetylhydroxyamino)propyl)-amino)-2-hydroxy-(2-(2-(3-(hydroxy(1-oxo-2-decenyl)amino)propyl)amino)-2-oxoethyl)-4-oxobutanoic acid, a siderophore produced by Sinorhizobium meliloti." [MetaCyc:PWY-761, PMID:11274118] synonym: "rhizobactin 1021 anabolism" EXACT [] synonym: "rhizobactin 1021 biosynthesis" EXACT [] synonym: "rhizobactin 1021 biosynthetic process, peptide formation" NARROW [] synonym: "rhizobactin 1021 biosynthetic process, peptide modification" NARROW [] synonym: "rhizobactin 1021 formation" EXACT [] synonym: "rhizobactin 1021 synthesis" EXACT [] xref: MetaCyc:PWY-761 is_a: GO:0019540 ! siderophore biosynthetic process from catechol is_a: GO:0046494 ! rhizobactin 1021 metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1902645 ! tertiary alcohol biosynthetic process [Term] id: GO:0019290 name: siderophore biosynthetic process namespace: biological_process alt_id: GO:0031178 alt_id: GO:0031180 def: "The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [GOC:go_curators] comment: See also the biological process term 'nonribosomal peptide biosynthetic process ; GO:0019184'. synonym: "siderochrome biosynthesis" NARROW [] synonym: "siderochrome biosynthetic process" NARROW [] synonym: "siderophore anabolism" EXACT [] synonym: "siderophore biosynthesis" EXACT [] synonym: "siderophore biosynthetic process, peptide formation" NARROW [] synonym: "siderophore biosynthetic process, peptide modification" NARROW [] synonym: "siderophore formation" EXACT [] synonym: "siderophore synthesis" EXACT [] is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0019292 name: tyrosine biosynthetic process from chorismate via 4-hydroxyphenylpyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine from other compounds, including chorismate, via the intermediate 4-hydroxyphenylpyruvate." [GOC:go_curators] synonym: "tyrosine anabolism from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via p-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine formation from chorismate via 4-hydroxyphenylpyruvate" EXACT [] synonym: "tyrosine synthesis from chorismate via 4-hydroxyphenylpyruvate" EXACT [] xref: MetaCyc:TYRSYN is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0019293 name: tyrosine biosynthetic process, by oxidation of phenylalanine namespace: biological_process alt_id: GO:0019291 def: "The chemical reactions and pathways resulting in the formation of tyrosine by the oxidation of phenylalanine." [GOC:go_curators] synonym: "tyrosine anabolism from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine anabolism, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine biosynthetic process from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine formation, by oxidation of phenylalanine" EXACT [] synonym: "tyrosine synthesis from chorismate via L-phenylalanine" EXACT [] synonym: "tyrosine synthesis, by oxidation of phenylalanine" EXACT [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0006571 ! tyrosine biosynthetic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019294 name: keto-3-deoxy-D-manno-octulosonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of keto-3-deoxy-D-manno-octulosonic acid, an acidic sugar present in lipopolysaccharides of the outer membranes of some Gram-negative bacteria." [CHEBI:32817, ISBN:0198506732] synonym: "KDO biosynthesis" EXACT [] synonym: "KDO biosynthetic process" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid anabolism" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid biosynthesis" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid formation" EXACT [] synonym: "keto-3-deoxy-D-manno-octulosonic acid synthesis" EXACT [] synonym: "ketodeoxyoctanoate biosynthetic process" RELATED [ISBN:0198506732] xref: MetaCyc:KDOSYN-PWY is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046400 ! keto-3-deoxy-D-manno-octulosonic acid metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0019295 name: coenzyme M biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [ISBN:0198547684] synonym: "coenzyme M anabolism" EXACT [] synonym: "coenzyme M biosynthesis" EXACT [] synonym: "coenzyme M formation" EXACT [] synonym: "coenzyme M synthesis" EXACT [] xref: MetaCyc:P261-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0019296 ! coenzyme M metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0019296 name: coenzyme M metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme M (2-thioethansulfonate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme M metabolism" EXACT [] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019297 name: coenzyme B metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [GOC:go_curators] synonym: "coenzyme B metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019298 name: coenzyme B biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzyme B (7-mercaptoheptanoylthreonine phosphate), a coenzyme involved in the utilization of methane by methanogenic prokaryotes." [PMID:10940051] synonym: "coenzyme B anabolism" EXACT [] synonym: "coenzyme B biosynthesis" EXACT [] synonym: "coenzyme B formation" EXACT [] synonym: "coenzyme B synthesis" EXACT [] xref: MetaCyc:P241-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019297 ! coenzyme B metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0019299 name: rhamnose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnose, the hexose 6-deoxy-L-mannose. Rhamnose occurs commonly as a compound of plant glycosides, in polysaccharides of gums and mucilages, and in bacterial polysaccharides. It is also a component of some plant cell wall polysaccharides and frequently acts as the sugar components of flavonoids." [ISBN:0198506732] synonym: "rhamnose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019300 name: rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] synonym: "rhamnose anabolism" EXACT [] synonym: "rhamnose biosynthesis" EXACT [] synonym: "rhamnose formation" EXACT [] synonym: "rhamnose synthesis" EXACT [] is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019301 name: rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose." [ISBN:0198506732] synonym: "rhamnose breakdown" EXACT [] synonym: "rhamnose catabolism" EXACT [] synonym: "rhamnose degradation" EXACT [] xref: MetaCyc:RHAMCAT-PWY is_a: GO:0019299 ! rhamnose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019302 name: D-ribose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-ribose, (ribo-pentose)." [ISBN:0198506732] synonym: "D-ribose anabolism" EXACT [] synonym: "D-ribose biosynthesis" EXACT [] synonym: "D-ribose formation" EXACT [] synonym: "D-ribose synthesis" EXACT [] is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0019303 name: D-ribose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-ribose (ribo-pentose)." [ISBN:0198506732] synonym: "D-ribose breakdown" EXACT [] synonym: "D-ribose catabolism" EXACT [] synonym: "D-ribose degradation" EXACT [] xref: MetaCyc:RIBOKIN-PWY is_a: GO:0006014 ! D-ribose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0019304 name: anaerobic rhamnose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of rhamnose, the hexose 6-deoxy-L-mannose, that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic rhamnose breakdown" EXACT [] synonym: "anaerobic rhamnose catabolism" EXACT [] synonym: "anaerobic rhamnose degradation" EXACT [] is_a: GO:0019301 ! rhamnose catabolic process [Term] id: GO:0019305 name: dTDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-rhamnose, a substance composed of rhamnose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-rhamnose anabolism" EXACT [] synonym: "dTDP-rhamnose biosynthesis" EXACT [] synonym: "dTDP-rhamnose formation" EXACT [] synonym: "dTDP-rhamnose synthesis" EXACT [] xref: MetaCyc:DTDPRHAMSYN-PWY xref: MetaCyc:PWY-3221 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046383 ! dTDP-rhamnose metabolic process [Term] id: GO:0019306 name: GDP-D-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-D-rhamnose, a substance composed of rhamnose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-D-rhamnose anabolism" EXACT [] synonym: "GDP-D-rhamnose biosynthesis" EXACT [] synonym: "GDP-D-rhamnose formation" EXACT [] synonym: "GDP-D-rhamnose synthesis" EXACT [] xref: MetaCyc:GDPRHAMSYN-PWY is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046382 ! GDP-D-rhamnose metabolic process [Term] id: GO:0019307 name: mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] synonym: "mannose anabolism" EXACT [] synonym: "mannose biosynthesis" EXACT [] synonym: "mannose formation" EXACT [] synonym: "mannose synthesis" EXACT [] is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0019308 name: dTDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP-mannose, a substance composed of mannose in glycosidic linkage with deoxyribosylthymine diphosphate." [GOC:ai] synonym: "dTDP-mannose anabolism" EXACT [] synonym: "dTDP-mannose biosynthesis" EXACT [] synonym: "dTDP-mannose formation" EXACT [] synonym: "dTDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046371 ! dTDP-mannose metabolic process [Term] id: GO:0019309 name: mannose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannose, the aldohexose manno-hexose, the C-2 epimer of glucose." [GOC:ai] synonym: "mannose breakdown" EXACT [] synonym: "mannose catabolism" EXACT [] synonym: "mannose degradation" EXACT [] xref: MetaCyc:MANNCAT-PWY is_a: GO:0006013 ! mannose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019310 name: inositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [CHEBI:24848, GOC:go_curators] synonym: "inositol breakdown" EXACT [] synonym: "inositol catabolism" EXACT [] synonym: "inositol degradation" EXACT [] synonym: "myo-inositol catabolic process" NARROW [] synonym: "myo-inositol catabolism" NARROW [] synonym: "vitamin Bh catabolic process" EXACT [] synonym: "vitamin Bh catabolism" EXACT [] xref: MetaCyc:P562-PWY is_a: GO:0006020 ! inositol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019311 name: sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the ketohexose xylo-2-hexulose. Sorbose is produced commercially by fermentation and is used as an intermediate in the manufacture of ascorbic acid." [ISBN:0198506732] synonym: "sorbose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019312 name: L-sorbose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbose, the L-enantiomer of the ketohexose xylo-2-hexulose. L-sorbose is formed by bacterial oxidation of sorbitol." [CHEBI:17266, GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-sorbose metabolism" EXACT [] xref: MetaCyc:P302-PWY is_a: GO:0019311 ! sorbose metabolic process [Term] id: GO:0019313 name: allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allose, allo-hexose, an aldohexose similar to glucose, differing only in the configuration of the hydroxyl group of C-3." [ISBN:0198506732] synonym: "allose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0019314 name: D-allose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose metabolism" EXACT [] is_a: GO:0019313 ! allose metabolic process [Term] id: GO:0019315 name: D-allose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose anabolism" EXACT [] synonym: "D-allose biosynthesis" EXACT [] synonym: "D-allose formation" EXACT [] synonym: "D-allose synthesis" EXACT [] is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046366 ! allose biosynthetic process [Term] id: GO:0019316 name: D-allose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-allose, the D-enantiomer of allo-hexose, an aldohexose similar to glucose." [CHEBI:17393, GOC:ai, GOC:jsg, GOC:mah] synonym: "D-allose breakdown" EXACT [] synonym: "D-allose catabolism" EXACT [] synonym: "D-allose degradation" EXACT [] xref: MetaCyc:PWY0-44 is_a: GO:0019314 ! D-allose metabolic process is_a: GO:0046367 ! allose catabolic process [Term] id: GO:0019317 name: fucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fucose (6-deoxygalactose)." [GOC:jl] synonym: "fucose breakdown" EXACT [] synonym: "fucose catabolism" EXACT [] synonym: "fucose degradation" EXACT [] xref: MetaCyc:FUCCAT-PWY is_a: GO:0006004 ! fucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019318 name: hexose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019319 name: hexose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose anabolism" EXACT [] synonym: "hexose biosynthesis" EXACT [] synonym: "hexose formation" EXACT [] synonym: "hexose synthesis" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019320 name: hexose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexose, any monosaccharide with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexose breakdown" EXACT [] synonym: "hexose catabolism" EXACT [] synonym: "hexose degradation" EXACT [] is_a: GO:0019318 ! hexose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019321 name: pentose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0019322 name: pentose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose anabolism" EXACT [] synonym: "pentose biosynthesis" EXACT [] synonym: "pentose formation" EXACT [] synonym: "pentose synthesis" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046364 ! monosaccharide biosynthetic process [Term] id: GO:0019323 name: pentose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pentose, any monosaccharide with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentose breakdown" EXACT [] synonym: "pentose catabolism" EXACT [] synonym: "pentose degradation" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046365 ! monosaccharide catabolic process [Term] id: GO:0019324 name: L-lyxose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-lyxose, the L-enantiomer of aldopentose lyxo-pentose, the C-2 epimer of xylose." [GOC:jsg, GOC:mah, ISBN:0198506732] synonym: "L-lyxose metabolism" EXACT [] xref: MetaCyc:LYXMET-PWY is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019325 name: anaerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the absence of oxygen." [GOC:ai] synonym: "anaerobic fructose breakdown" EXACT [] synonym: "anaerobic fructose catabolism" EXACT [] synonym: "anaerobic fructose degradation" EXACT [] xref: MetaCyc:ANAEROFRUCAT-PWY is_a: GO:0006001 ! fructose catabolic process is_a: GO:0019317 ! fucose catabolic process [Term] id: GO:0019326 name: nitrotoluene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nitrotoluene, any methylbenzene molecule with NO2 group(s) attached." [GOC:ai] synonym: "nitrotoluene metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0072490 ! toluene-containing compound metabolic process [Term] id: GO:0019327 name: lead sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lead sulfide to lead sulfate." [MetaCyc:P301-PWY] synonym: "lead sulphide oxidation" EXACT [GOC:mah] synonym: "oxidation of galena" EXACT [] synonym: "oxidation of lead sulfide" EXACT [GOC:curators] xref: MetaCyc:P301-PWY is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019328 name: anaerobic gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the absence of oxygen." [GOC:jl] synonym: "anaerobic gallate breakdown" EXACT [] synonym: "anaerobic gallate catabolism" EXACT [] synonym: "anaerobic gallate degradation" EXACT [] synonym: "anaerobic gallic acid catabolic process" EXACT [] synonym: "anaerobic gallic acid catabolism" EXACT [] synonym: "gallate fermentation" EXACT [] xref: MetaCyc:P3-PWY is_a: GO:0019396 ! gallate catabolic process [Term] id: GO:0019329 name: ammonia oxidation namespace: biological_process def: "The chemical reactions and pathways by which ammonia or ammonium is converted to molecular nitrogen or another nitrogen compound, with accompanying loss of electrons." [GOC:mah, MetaCyc:AMMOXID-PWY, MetaCyc:P303-PWY, MetaCyc:PWY-2242] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019330 name: aldoxime metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldoximes, compounds derived by the reaction of an aldose with hydroxylamine, thus containing the aldoxime group -HC=NOH." [CHEBI:22307, GOC:curators] synonym: "aldoxime metabolism" EXACT [] xref: MetaCyc:P345-PWY is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019331 name: anaerobic respiration, using ammonium as electron donor namespace: biological_process def: "The oxidation of ammonium (NH4) to nitrogen (N2) in the absence of oxygen, using nitrite (NO2) as the electron acceptor. It is suggested that hydroxylamine and ammonium are combined to yield hydrazine, which is subsequently oxidized to N2." [MetaCyc:P303-PWY] synonym: "anaerobic ammonium oxidation" BROAD [] synonym: "anammox" EXACT [] xref: MetaCyc:P303-PWY xref: Wikipedia:Anammox is_a: GO:0009061 ! anaerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019332 name: aerobic respiration, using nitrite as electron donor namespace: biological_process def: "The oxidation of nitrite (NO2) to nitrate (NO3), using oxygen (O2) as the electron acceptor. Nitrite oxidation is the final step in nitrification, the oxidation of ammonia to nitrate, and nitrite oxidoreductase (NOR) is the key enzyme complex that catalyzes the conversion of nitrite to nitrate in nitrite oxidizing species." [MetaCyc:P282-PWY] synonym: "nitrite oxidation" BROAD [] xref: MetaCyc:P282-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019333 name: denitrification pathway namespace: biological_process def: "The reduction of nitrate to dinitrogen by four reactions; each intermediate is transformed to the next lower oxidation state; also part of cellular bioenergetics; the nitrogen compounds can serve as terminal acceptors for electron transport phosphorylation in place of oxygen." [MetaCyc:DENITRIFICATION-PWY] xref: MetaCyc:DENITRIFICATION-PWY is_a: GO:0071941 ! nitrogen cycle metabolic process [Term] id: GO:0019334 name: p-cymene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of p-cymene, 1-methyl-4-isopropylbenzene, one of the alkyl-substituted aromatic hydrocarbons found in volatile oils from over 100 plants." [GOC:ai] synonym: "p-cymene breakdown" EXACT [] synonym: "p-cymene catabolism" EXACT [] synonym: "p-cymene degradation" EXACT [] xref: MetaCyc:PWY-741 is_a: GO:0018953 ! p-cymene metabolic process is_a: GO:0043694 ! monoterpene catabolic process is_a: GO:0072491 ! toluene-containing compound catabolic process [Term] id: GO:0019335 name: 3-methylquinoline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-methylquinoline, C10H9N, an aromatic compound composed of a benzene ring and a heterocyclic N-containing ring." [GOC:ai] synonym: "3-methylquinoline breakdown" EXACT [] synonym: "3-methylquinoline catabolism" EXACT [] synonym: "3-methylquinoline degradation" EXACT [] xref: MetaCyc:PWY-721 is_a: GO:0018930 ! 3-methylquinoline metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019336 name: phenol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring." [CHEBI:33853, GOC:go_curators, ISBN:0198506732] synonym: "phenol-containing compound breakdown" EXACT [GOC:curators] synonym: "phenol-containing compound catabolism" EXACT [GOC:curators] synonym: "phenol-containing compound degradation" EXACT [GOC:curators] xref: MetaCyc:PHENOLDEG-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019337 name: tetrachloroethylene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tetrachloroethylene, a derivative of ethene with the hydrogen atoms replaced by chlorines." [GOC:ai] synonym: "tetrachloroethene catabolic process" EXACT [] synonym: "tetrachloroethene catabolism" EXACT [] synonym: "tetrachloroethylene breakdown" EXACT [] synonym: "tetrachloroethylene catabolism" EXACT [] synonym: "tetrachloroethylene degradation" EXACT [] xref: MetaCyc:PCEDEG-PWY is_a: GO:0018967 ! tetrachloroethylene metabolic process is_a: GO:0042205 ! chlorinated hydrocarbon catabolic process [Term] id: GO:0019338 name: pentachlorophenol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentachlorophenol, a chlorinated insecticide and fungicide used primarily to protect timber from fungal rot and wood boring insects. Pentachlorophenol is significantly toxic to mammals, plants, and many microorganisms." [GOC:go_curators] synonym: "pentachlorophenol breakdown" EXACT [] synonym: "pentachlorophenol catabolism" EXACT [] synonym: "pentachlorophenol degradation" EXACT [] xref: MetaCyc:PCPDEG-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018961 ! pentachlorophenol metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0019339 name: parathion catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of parathion, a highly toxic organophosphate compound. Degradation of parathion by sunlight or liver enzymes can result in the formation of the active compound paraoxon which interferes with the nervous system through cholinesterase inhibition." [UM-BBD_pathwayID:pthn] synonym: "parathion breakdown" EXACT [] synonym: "parathion catabolism" EXACT [] synonym: "parathion degradation" EXACT [] xref: MetaCyc:PARATHION-DEGRADATION-PWY is_a: GO:0018952 ! parathion metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0046701 ! insecticide catabolic process is_a: GO:0051410 ! detoxification of nitrogen compound [Term] id: GO:0019340 name: dibenzofuran catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzofuran, a substance composed of two benzene rings linked by one ether bond and one carbon-carbon bond." [GOC:ai] synonym: "dibenzofuran breakdown" EXACT [] synonym: "dibenzofuran catabolism" EXACT [] synonym: "dibenzofuran degradation" EXACT [] xref: MetaCyc:P662-PWY is_a: GO:0018893 ! dibenzofuran metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019341 name: dibenzo-p-dioxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dibenzo-p-dioxin, a substance composed of two benzene rings linked by two ether bonds." [GOC:ai] synonym: "dibenzo-p-dioxin breakdown" EXACT [] synonym: "dibenzo-p-dioxin catabolism" EXACT [] synonym: "dibenzo-p-dioxin degradation" EXACT [] xref: MetaCyc:P661-PWY is_a: GO:0018894 ! dibenzo-p-dioxin metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019342 name: trypanothione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trypanothione (N1,N6,-bis(glutathionyl)spermidine) in two steps from glutathione and spermidine via an N1- or N8-glutathionylspermidine intermediate. Trypanothione appears to be an essential redox intermediate in intracellular thiol redox regulation. It also plays a role in protecting against oxidative stress." [MetaCyc:TRYPANOSYN-PWY, PMID:9677355] synonym: "trypanothione anabolism" EXACT [] synonym: "trypanothione biosynthesis" EXACT [] synonym: "trypanothione formation" EXACT [] synonym: "trypanothione synthesis" EXACT [] xref: MetaCyc:TRYPANOSYN-PWY is_a: GO:0046206 ! trypanothione metabolic process is_a: GO:1901687 ! glutathione derivative biosynthetic process [Term] id: GO:0019343 name: cysteine biosynthetic process via cystathionine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate cystathionine." [GOC:go_curators] synonym: "cysteine anabolism via cystathionine" EXACT [] synonym: "cysteine formation via cystathionine" EXACT [] synonym: "cysteine synthesis via cystathionine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019344 name: cysteine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] synonym: "cysteine anabolism" EXACT [] synonym: "cysteine biosynthesis" EXACT [] synonym: "cysteine formation" EXACT [] synonym: "cysteine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0019345 name: cysteine biosynthetic process via S-sulfo-L-cysteine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine, via the intermediate S-sulfo-L-cysteine." [GOC:go_curators] synonym: "cysteine anabolism via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine biosynthesis via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine biosynthetic process via S-sulpho-L-cysteine" EXACT [] synonym: "cysteine formation via S-sulfo-L-cysteine" EXACT [] synonym: "cysteine synthesis via S-sulfo-L-cysteine" EXACT [] is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0019346 name: transsulfuration namespace: biological_process def: "The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes." [MetaCyc:PWY-801] synonym: "homocysteine-cysteine interconversion" NARROW [] synonym: "transsulphuration" EXACT [] xref: MetaCyc:PWY-801 xref: Wikipedia:Transsulfuration_pathway is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009092 ! homoserine metabolic process is_a: GO:0050667 ! homocysteine metabolic process [Term] id: GO:0019347 name: GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-alpha-D-mannosylchitobiosyldiphosphodolichol, a substance composed of mannosylchitobiosyldiphosphodolichol in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol anabolism" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol biosynthesis" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol formation" EXACT [] synonym: "GDP-alpha-D-mannosylchitobiosyldiphosphodolichol synthesis" EXACT [] xref: MetaCyc:MANNOSYL-CHITO-DOLICHOL-BIOSYNTHESIS is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0016114 ! terpenoid biosynthetic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process is_a: GO:0046376 ! GDP-alpha-D-mannosylchitobiosyldiphosphodolichol metabolic process [Term] id: GO:0019348 name: dolichol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] synonym: "dolichol metabolism" EXACT [] is_a: GO:0016093 ! polyprenol metabolic process [Term] id: GO:0019349 name: ribitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribitol, a pentitol derived formally by reduction of the -CHO group of either D- or L-ribose. It occurs free in some plants and is a component of riboflavin." [ISBN:0198506732] synonym: "ribitol metabolism" EXACT [] is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019350 name: teichoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of teichoic acid, any polymer occurring in the cell wall, membrane or capsule of Gram-positive bacteria and containing chains of glycerol phosphate or ribitol phosphate residues." [ISBN:0198506732] synonym: "teichoic acid anabolism" EXACT [] synonym: "teichoic acid biosynthesis" EXACT [] synonym: "teichoic acid formation" EXACT [] synonym: "teichoic acid synthesis" EXACT [] xref: MetaCyc:TEICHOICACID-PWY is_a: GO:0016053 ! organic acid biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process is_a: GO:0046374 ! teichoic acid metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0019351 name: dethiobiotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dethiobiotin, a derivative of biotin in which the sulfur atom has been replaced by two hydrogen atoms." [GOC:ai, ISBN:0198506732] synonym: "desthiobiotin biosynthesis" EXACT [] synonym: "desthiobiotin biosynthetic process" EXACT [] synonym: "dethiobiotin anabolism" EXACT [] synonym: "dethiobiotin biosynthesis" EXACT [] synonym: "dethiobiotin formation" EXACT [] synonym: "dethiobiotin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0046450 ! dethiobiotin metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019352 name: protoporphyrinogen IX biosynthetic process from glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glycine." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism from glycine" EXACT [] synonym: "protoporphyrinogen IX formation from glycine" EXACT [] synonym: "protoporphyrinogen IX synthesis from glycine" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process [Term] id: GO:0019353 name: protoporphyrinogen IX biosynthetic process from glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX from other compounds, including glutamate." [GOC:go_curators] synonym: "protoporphyrinogen IX anabolism from glutamate" EXACT [] synonym: "protoporphyrinogen IX formation from glutamate" EXACT [] synonym: "protoporphyrinogen IX synthesis from glutamate" EXACT [] is_a: GO:0006782 ! protoporphyrinogen IX biosynthetic process is_a: GO:0033526 ! tetrapyrrole biosynthetic process from glutamate [Term] id: GO:0019354 name: siroheme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of siroheme, a tetrahydroporphyrin with adjacent, reduced pyrrole rings." [ISBN:0198506732] synonym: "sirohaem biosynthesis" EXACT [] synonym: "sirohaem biosynthetic process" EXACT [] synonym: "siroheme anabolism" EXACT [] synonym: "siroheme biosynthesis" EXACT [] synonym: "siroheme formation" EXACT [] synonym: "siroheme synthase activity" RELATED [] synonym: "siroheme synthesis" EXACT [] xref: AraCyc:PWYQT-62 xref: MetaCyc:PWY-5194 is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046156 ! siroheme metabolic process [Term] id: GO:0019355 name: nicotinamide nucleotide biosynthetic process from aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including aspartate." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism from aspartate" EXACT [] synonym: "nicotinamide nucleotide formation from aspartate" EXACT [] synonym: "nicotinamide nucleotide synthesis from aspartate" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019356 name: nicotinate nucleotide biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinate nucleotide from other compounds, including tryptophan." [GOC:go_curators] synonym: "nicotinate nucleotide anabolism from tryptophan" EXACT [] synonym: "nicotinate nucleotide formation from tryptophan" EXACT [] synonym: "nicotinate nucleotide synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process [Term] id: GO:0019357 name: nicotinate nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinate (pyridine 3-carboxylic acid)." [GOC:go_curators] synonym: "nicotinate nucleotide anabolism" EXACT [] synonym: "nicotinate nucleotide biosynthesis" EXACT [] synonym: "nicotinate nucleotide formation" EXACT [] synonym: "nicotinate nucleotide synthesis" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0046497 ! nicotinate nucleotide metabolic process [Term] id: GO:0019358 name: nicotinate nucleotide salvage namespace: biological_process def: "The generation of nicotinate nucleotide without de novo synthesis." [GOC:go_curators] synonym: "nicotinate nucleotide biosynthesis, salvage pathway" EXACT [] synonym: "nicotinate nucleotide biosynthetic process, salvage pathway" EXACT [] xref: MetaCyc:PWY-5381 xref: MetaCyc:PYRIDNUCSAL-PWY is_a: GO:0019357 ! nicotinate nucleotide biosynthetic process is_a: GO:0019365 ! pyridine nucleotide salvage [Term] id: GO:0019359 name: nicotinamide nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotides, any nucleotide that contains combined nicotinamide." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism" EXACT [] synonym: "nicotinamide nucleotide biosynthesis" EXACT [] synonym: "nicotinamide nucleotide formation" EXACT [] synonym: "nicotinamide nucleotide synthesis" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019360 name: nicotinamide nucleotide biosynthetic process from niacinamide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide nucleotide from other compounds, including niacinamide." [GOC:go_curators] synonym: "nicotinamide nucleotide anabolism from niacinamide" EXACT [] synonym: "nicotinamide nucleotide formation from niacinamide" EXACT [] synonym: "nicotinamide nucleotide synthesis from niacinamide" EXACT [] is_a: GO:0006769 ! nicotinamide metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0019361 name: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA, a derivative of coenzyme A." [GOC:ai] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA anabolism" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthesis" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA formation" EXACT [] synonym: "2'-(5''-triphosphoribosyl)-3'-dephospho-CoA synthesis" EXACT [] xref: MetaCyc:P2-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0046432 ! 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA metabolic process [Term] id: GO:0019362 name: pyridine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl] synonym: "pyridine nucleotide metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019363 name: pyridine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] synonym: "pyridine nucleotide anabolism" EXACT [] synonym: "pyridine nucleotide biosynthesis" EXACT [] synonym: "pyridine nucleotide formation" EXACT [] synonym: "pyridine nucleotide synthesis" EXACT [] xref: MetaCyc:PYRIDNUCSYN-PWY is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0019364 name: pyridine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base." [GOC:jl, GOC:pde, GOC:vw] synonym: "pyridine nucleotide breakdown" EXACT [] synonym: "pyridine nucleotide catabolism" EXACT [] synonym: "pyridine nucleotide degradation" EXACT [] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0072526 ! pyridine-containing compound catabolic process [Term] id: GO:0019365 name: pyridine nucleotide salvage namespace: biological_process def: "Any process that generates a pyridine nucleotide, a nucleotide characterized by a pyridine derivative as a nitrogen base, from derivatives of them without de novo synthesis." [GOC:jl] synonym: "pyridine nucleotide cycling" EXACT [] is_a: GO:0019363 ! pyridine nucleotide biosynthetic process is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0019367 name: fatty acid elongation, saturated fatty acid namespace: biological_process def: "Elongation of a saturated fatty acid chain." [GOC:mah] xref: MetaCyc:FASYN-ELONG-PWY is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019368 name: fatty acid elongation, unsaturated fatty acid namespace: biological_process def: "Elongation of a fatty acid chain into which one or more C-C double bonds have been introduced." [GOC:mah] xref: MetaCyc:PWY0-862 is_a: GO:0030497 ! fatty acid elongation [Term] id: GO:0019369 name: arachidonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arachidonic acid, a straight chain fatty acid with 20 carbon atoms and four double bonds per molecule. Arachidonic acid is the all-Z-(5,8,11,14)-isomer." [ISBN:0198506732] synonym: "arachidonic acid metabolism" EXACT [] xref: Wikipedia:Arachidonic_acid is_a: GO:0001676 ! long-chain fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0019370 name: leukotriene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:go_curators] synonym: "leukotriene anabolism" EXACT [] synonym: "leukotriene biosynthesis" EXACT [] synonym: "leukotriene formation" EXACT [] synonym: "leukotriene synthesis" EXACT [] xref: Wikipedia:Leukotriene#Leukotriene_synthesis is_a: GO:0006691 ! leukotriene metabolic process is_a: GO:0046456 ! icosanoid biosynthetic process [Term] id: GO:0019371 name: cyclooxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which prostaglandins are formed from arachidonic acid, and in which prostaglandin-endoperoxide synthase (cyclooxygenase) catalyzes the committed step in the conversion of arachidonic acid to the prostaglandin-endoperoxides PGG2 and PGH2." [PMID:19854273] is_a: GO:0019369 ! arachidonic acid metabolic process relationship: part_of GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0019372 name: lipoxygenase pathway namespace: biological_process def: "The chemical reactions and pathways by which an unsaturated fatty acid (such as arachidonic acid or linolenic acid) is converted to other compounds, and in which the first step is hydroperoxide formation catalyzed by lipoxygenase." [GOC:mah, PMID:17163881] is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0019373 name: epoxygenase P450 pathway namespace: biological_process def: "The chemical reactions and pathways by which arachidonic acid is converted to other compounds including epoxyeicosatrienoic acids and dihydroxyeicosatrienoic acids." [GOC:mah, PMID:17979511] is_a: GO:0019369 ! arachidonic acid metabolic process [Term] id: GO:0019374 name: galactolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0019375 name: galactolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid anabolism" EXACT [] synonym: "galactolipid biosynthesis" EXACT [] synonym: "galactolipid formation" EXACT [] synonym: "galactolipid synthesis" EXACT [] is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0019376 name: galactolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactolipids, any glycolipid containing one of more residues of galactose and/or N-acetylgalactosamine." [ISBN:0198506732] synonym: "galactolipid breakdown" EXACT [] synonym: "galactolipid catabolism" EXACT [] synonym: "galactolipid degradation" EXACT [] is_a: GO:0019374 ! galactolipid metabolic process is_a: GO:0019377 ! glycolipid catabolic process [Term] id: GO:0019377 name: glycolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] synonym: "glycolipid breakdown" EXACT [] synonym: "glycolipid catabolism" EXACT [] synonym: "glycolipid degradation" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0019379 name: sulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin) namespace: biological_process def: "The pathway by which inorganic sulfate is processed and incorporated into sulfated compounds, where the phosphoadenylyl sulfate reduction step is catalyzed by the enzyme phosphoadenylyl-sulfate reductase (thioredoxin) (EC:1.8.4.8)." [GOC:jl] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by a phosphoadenylyl-sulphate reductase (thioredoxin)" EXACT [] xref: MetaCyc:SO4ASSIM-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019380 name: 3-phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-phenylpropionate, the anion of phenylpropanoic acid." [GOC:ai] synonym: "3-phenylpropionate breakdown" EXACT [] synonym: "3-phenylpropionate catabolism" EXACT [] synonym: "3-phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY xref: MetaCyc:P281-PWY is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018962 ! 3-phenylpropionate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019381 name: atrazine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide." [GOC:jl, UM-BBD_pathwayID:atr] synonym: "atrazine breakdown" EXACT [] synonym: "atrazine catabolism" EXACT [] synonym: "atrazine degradation" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0018873 ! atrazine metabolic process is_a: GO:0042204 ! s-triazine compound catabolic process [Term] id: GO:0019382 name: carbon tetrachloride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of carbon tetrachloride, a toxic, carcinogenic compound which is used as a general solvent in industrial degreasing operations. It is also used as grain fumigant and a chemical intermediate in the production of refrigerants." [GOC:go_curators] synonym: "carbon tetrachloride breakdown" EXACT [] synonym: "carbon tetrachloride catabolism" EXACT [] synonym: "carbon tetrachloride degradation" EXACT [] is_a: GO:0018885 ! carbon tetrachloride metabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019383 name: (+)-camphor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (+)-camphor, a bicyclic monoterpene ketone." [UM-BBD_pathwayID:cam] synonym: "(+)-camphor breakdown" EXACT [] synonym: "(+)-camphor catabolism" EXACT [] synonym: "(+)-camphor degradation" EXACT [] xref: MetaCyc:P601-PWY is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0018882 ! (+)-camphor metabolic process is_a: GO:0042182 ! ketone catabolic process [Term] id: GO:0019384 name: caprolactam catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of caprolactam, hexahydro-2h-azepin-2-one, a cyclic amide of caproic acid." [CHEBI:23000, GOC:curators] synonym: "caprolactam breakdown" EXACT [] synonym: "caprolactam catabolism" EXACT [] synonym: "caprolactam degradation" EXACT [] xref: MetaCyc:P621-PWY is_a: GO:0018883 ! caprolactam metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019385 name: methanogenesis, from acetate namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including acetate." [GOC:ai] synonym: "methane biosynthesis from acetate" EXACT [] synonym: "methane biosynthetic process from acetate" EXACT [] xref: MetaCyc:METH-ACETATE-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019386 name: methanogenesis, from carbon dioxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2)." [GOC:ai] synonym: "methane biosynthesis from carbon dioxide" EXACT [] synonym: "methane biosynthetic process from carbon dioxide" EXACT [] xref: MetaCyc:METHANOGENESIS-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019387 name: methanogenesis, from methanol namespace: biological_process def: "The formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other components, including methanol." [GOC:ai] synonym: "methane biosynthesis from methanol" EXACT [] synonym: "methane biosynthetic process from methanol" EXACT [] xref: MetaCyc:METHFORM-PWY is_a: GO:0015948 ! methanogenesis [Term] id: GO:0019388 name: galactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactose, the aldohexose galacto-hexose." [ISBN:0198506732] synonym: "galactose breakdown" EXACT [] synonym: "galactose catabolism" EXACT [] synonym: "galactose degradation" EXACT [] xref: MetaCyc:GALDEG-PWY is_a: GO:0006012 ! galactose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0019389 name: glucuronoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucuronosides, any compound formed by combination in glycosidic linkage of a hydroxy compound with the anomeric carbon atom of a glucuronate." [ISBN:0198506732] synonym: "glucuronide metabolic process" EXACT [] synonym: "glucuronide metabolism" EXACT [] synonym: "glucuronoside metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019390 name: glucuronoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] synonym: "glucuronide biosynthesis" EXACT [] synonym: "glucuronide biosynthetic process" EXACT [] synonym: "glucuronoside anabolism" EXACT [] synonym: "glucuronoside biosynthesis" EXACT [] synonym: "glucuronoside formation" EXACT [] synonym: "glucuronoside synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019391 name: glucuronoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronosides, compound composed of a hydroxy compound linked to a glucuronate residue." [ISBN:0198506732] synonym: "glucuronide catabolic process" EXACT [] synonym: "glucuronide catabolism" EXACT [] synonym: "glucuronoside breakdown" EXACT [] synonym: "glucuronoside catabolism" EXACT [] synonym: "glucuronoside degradation" EXACT [] xref: MetaCyc:GLUCUROCAT-PWY is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0019389 ! glucuronoside metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019392 name: glucarate metabolic process namespace: biological_process alt_id: GO:0019581 def: "The chemical reactions and pathways involving glucarate, the dianion of glucaric acid, an aldaric acid derived from either glucose or gulose. There are two enantiomers L- and D-glucarate." [ISBN:0198506732] synonym: "glucarate metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019393 name: glucarate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucarate, the anion of glucaric acid." [ISBN:0198506732] synonym: "glucarate anabolism" EXACT [] synonym: "glucarate biosynthesis" EXACT [] synonym: "glucarate formation" EXACT [] synonym: "glucarate synthesis" EXACT [] is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019578 ! aldaric acid biosynthetic process [Term] id: GO:0019394 name: glucarate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid." [ISBN:0198506732] synonym: "glucarate breakdown" EXACT [] synonym: "glucarate catabolism" EXACT [] synonym: "glucarate degradation" EXACT [] xref: MetaCyc:GLUCARDEG-PWY is_a: GO:0019392 ! glucarate metabolic process is_a: GO:0019579 ! aldaric acid catabolic process [Term] id: GO:0019395 name: fatty acid oxidation namespace: biological_process def: "The removal of one or more electrons from a fatty acid, with or without the concomitant removal of a proton or protons, by reaction with an electron-accepting substance, by addition of oxygen or by removal of hydrogen." [ISBN:0198506732, MetaCyc:FAO-PWY] xref: MetaCyc:FAO-PWY is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0034440 ! lipid oxidation [Term] id: GO:0019396 name: gallate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid (3,4,5-trihydroxybenzoic acid)." [GOC:jl] synonym: "gallate breakdown" EXACT [] synonym: "gallate catabolism" EXACT [] synonym: "gallate degradation" EXACT [] synonym: "gallic acid catabolic process" EXACT [] synonym: "gallic acid catabolism" EXACT [] is_a: GO:0018918 ! gallate metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019397 name: gallate catabolic process via 2-pyrone-4,6-dicarboxylate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, via the intermediate 2-pyrone-4,6-dicarboxylate." [GOC:jl] synonym: "gallate breakdown via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallate degradation via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolic process via 2-pyrone-4,6-dicarboxylate" EXACT [] synonym: "gallic acid catabolism via 2-pyrone-4,6-dicarboxylate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-I-PWY is_a: GO:0042195 ! aerobic gallate catabolic process [Term] id: GO:0019398 name: gallate catabolic process via gallate dioxygenase activity namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, where the first step is the conversion of gallate to (1E)-4-oxobut-1-ene-1,2,4-tricarboxylate catalyzed by gallate dioxygenase." [GOC:bf, GOC:jl] synonym: "gallate breakdown via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallate catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" BROAD [GOC:bf] synonym: "gallate degradation via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolic process via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] synonym: "gallic acid catabolism via 4-carboxy-2-hydroxhexa-2,3-dienedioate" EXACT [] xref: MetaCyc:GALLATE-DEGRADATION-II-PWY is_a: GO:0042195 ! aerobic gallate catabolic process [Term] id: GO:0019399 name: cyclohexanol oxidation namespace: biological_process def: "The cyclohexanol metabolic process in which cyclohexanol is converted to adipate." [MetaCyc:CYCLOHEXANOL-OXIDATION-PWY] xref: MetaCyc:CYCLOHEXANOL-OXIDATION-PWY is_a: GO:0018891 ! cyclohexanol metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019400 name: alditol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol metabolism" EXACT [] is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019401 name: alditol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol anabolism" EXACT [] synonym: "alditol biosynthesis" EXACT [] synonym: "alditol formation" EXACT [] synonym: "alditol synthesis" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0019402 name: galactitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019403 name: galactitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol anabolism" EXACT [] synonym: "galactitol biosynthesis" EXACT [] synonym: "galactitol formation" EXACT [] synonym: "galactitol synthesis" EXACT [] is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0019404 name: galactitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactitol, the hexitol derived by the reduction of the aldehyde group of either D- or L-galactose." [ISBN:0198506732] synonym: "galactitol breakdown" EXACT [] synonym: "galactitol catabolism" EXACT [] synonym: "galactitol degradation" EXACT [] xref: MetaCyc:GALACTITOLCAT-PWY is_a: GO:0019402 ! galactitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0019405 name: alditol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alditols, any polyhydric alcohol derived from the acyclic form of a monosaccharide by reduction of its aldehyde or keto group to an alcoholic group." [ISBN:0198506732] synonym: "alditol breakdown" EXACT [] synonym: "alditol catabolism" EXACT [] synonym: "alditol degradation" EXACT [] is_a: GO:0019400 ! alditol metabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process is_a: GO:0046174 ! polyol catabolic process [Term] id: GO:0019406 name: hexitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol anabolism" EXACT [] synonym: "hexitol biosynthesis" EXACT [] synonym: "hexitol formation" EXACT [] synonym: "hexitol synthesis" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019401 ! alditol biosynthetic process [Term] id: GO:0019407 name: hexitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732] synonym: "hexitol breakdown" EXACT [] synonym: "hexitol catabolism" EXACT [] synonym: "hexitol degradation" EXACT [] is_a: GO:0006059 ! hexitol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019408 name: dolichol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichols, any 2,3-dihydropolyprenol derived from four or more linked isoprene units." [ISBN:0198506732] synonym: "dolichol anabolism" EXACT [] synonym: "dolichol biosynthesis" EXACT [] synonym: "dolichol formation" EXACT [] synonym: "dolichol synthesis" EXACT [] is_a: GO:0016094 ! polyprenol biosynthetic process is_a: GO:0019348 ! dolichol metabolic process [Term] id: GO:0019409 name: aerobic respiration, using ammonia as electron donor namespace: biological_process def: "The metabolic process in which ammonia (NH3) is oxidized to nitrite (NO2) in the presence of oxygen; enzymatic reactions convert ammonia to hydrazine, and hydrazine to nitrite." [MetaCyc:AMMOXID-PWY] synonym: "aerobic ammonia oxidation to nitrite via hydrazine" EXACT [GOC:mah] xref: MetaCyc:AMMOXID-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds is_a: GO:0019329 ! ammonia oxidation is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0019410 name: aerobic respiration, using carbon monoxide as electron donor namespace: biological_process def: "The metabolic process in which carbon monoxide (CO) is oxidized to carbon dioxide (CO2) to generate energy. Conservation of energy in this process likely uses sodium ion gradients for ATP synthesis and is coupled to quantitative sulfide methylation." [PMID:18024677] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019411 name: aerobic respiration, using ferrous ions as electron donor namespace: biological_process def: "The metabolic process in which ferrous ions (Fe2+) are oxidized to ferric ions (Fe3+) to generate energy, coupled to the reduction of carbon dioxide." [ISBN:3131084111] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019412 name: aerobic respiration, using hydrogen as electron donor namespace: biological_process def: "The oxidation of hydrogen (H2) to water (H2O), using oxygen (O2) as the electron acceptor. A hydrogenase enzyme binds H2 and the hydrogen atoms are passed through an electron transfer chain to O2 to form water." [MetaCyc:P283-PWY] synonym: "hydrogen oxidation" BROAD [] xref: MetaCyc:P283-PWY is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019413 name: acetate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate, the anion of acetic acid." [GOC:go_curators] synonym: "acetate anabolism" EXACT [] synonym: "acetate biosynthesis" EXACT [] synonym: "acetate formation" EXACT [] synonym: "acetate synthesis" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process [Term] id: GO:0019414 name: aerobic respiration, using sulfur or sulfate as electron donor namespace: biological_process def: "An aerobic respiration process in which a sulfur-containing molecule (hydrogen sulfide, sulfur, sulfite, thiosulfate, and various polythionates) is oxidized." [PMID:11425697] synonym: "aerobic respiration, using sulphur or sulphate as electron donor" EXACT [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0015975 ! energy derivation by oxidation of reduced inorganic compounds [Term] id: GO:0019415 name: acetate biosynthetic process from carbon monoxide namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetate from other compounds, including carbon monoxide." [GOC:go_curators] synonym: "acetate anabolism from carbon monoxide" EXACT [] synonym: "acetate formation from carbon monoxide" EXACT [] synonym: "acetate synthesis from carbon monoxide" EXACT [] synonym: "carbon monoxide dehydrogenase pathway" EXACT [] xref: MetaCyc:CODH-PWY is_a: GO:0019413 ! acetate biosynthetic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019416 name: polythionate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of thiosulfate to tetrathionate, using cytochrome c as an electron acceptor." [MetaCyc:THIOSULFOX-PWY] xref: MetaCyc:THIOSULFOX-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019417 name: sulfur oxidation namespace: biological_process def: "The chemical reactions and pathways resulting the addition of oxygen to elemental sulfur." [GOC:jl, MetaCyc:FESULFOX-PWY, MetaCyc:SULFUROX-PWY] synonym: "sulphur oxidation" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019418 name: sulfide oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of sulfide to elemental sulfur in a higher oxidation state, or to sulfite or sulfate." [MetaCyc:P222-PWY, MetaCyc:P223-PWY, MetaCyc:PWY-5274, MetaCyc:PWY-5285] synonym: "sulphide oxidation" EXACT [] xref: MetaCyc:P222-PWY is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019419 name: sulfate reduction namespace: biological_process alt_id: GO:0019421 def: "The chemical reactions and pathways resulting in the reduction of sulfate to another sulfur-containing ion or compound such as hydrogen sulfide, adenosine-phosphosulfate (APS) or thiosulfate." [MetaCyc:DISSULFRED-PWY, MetaCyc:P224-PWY, MetaCyc:SO4ASSIM-PWY, MetaCyc:SULFMETII-PWY] synonym: "assimilatory sulfate reduction" NARROW [] synonym: "assimilatory sulphate reduction" NARROW [] synonym: "sulfate reduction, APS pathway" NARROW [] synonym: "sulphate reduction" EXACT [] synonym: "sulphate reduction, APS pathway" NARROW [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019420 name: dissimilatory sulfate reduction namespace: biological_process def: "The reduction of sulfate to hydrogen sulfide, which acts as a terminal electron acceptor. Sulfate is activated to adenosine-phosphosulfate (APS) which is then reduced to sulfite, which is in turn reduced to hydrogen sulfide." [GOC:jl, MetaCyc:DISSULFRED-PWY] synonym: "dissimilatory sulphate reduction" EXACT [] xref: MetaCyc:DISSULFRED-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019422 name: disproportionation of elemental sulfur namespace: biological_process def: "The process in which sulfur compounds with an intermediate oxidation state serve as both electron donors and electron acceptors in an energy-generating redox process. The reaction takes place anaerobically, in light and in the absence of CO2." [MetaCyc:P203-PWY] synonym: "disproportionation of elemental sulphur" EXACT [] xref: MetaCyc:P203-PWY is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019423 name: sulfur oxidation, ferric ion-dependent namespace: biological_process def: "A sulfur oxidation process that proceeds via the reaction catalyzed by sulfur:ferric ion oxidoreductase, and requires the presence of ferric ion (Fe3+)." [MetaCyc:FESULFOX-PWY] synonym: "sulphur oxidation, ferric ion-dependent" EXACT [] xref: MetaCyc:FESULFOX-PWY is_a: GO:0019417 ! sulfur oxidation [Term] id: GO:0019424 name: sulfide oxidation, using siroheme sulfite reductase namespace: biological_process alt_id: GO:0019425 def: "A sulfide oxidation process that proceeds via the reaction catalyzed by siroheme sulfite reductase." [MetaCyc:P223-PWY] synonym: "sulfide oxidation, using sirohaem sulfite reductase" EXACT [] synonym: "sulfur oxidation, using sirohaem sulfite reductase" RELATED [] synonym: "sulfur oxidation, using siroheme sulfite reductase" RELATED [] synonym: "sulphide oxidation, using siroheme sulphite reductase" EXACT [] synonym: "sulphur oxidation, using siroheme sulphite reductase" RELATED [] xref: MetaCyc:P223-PWY is_a: GO:0019418 ! sulfide oxidation [Term] id: GO:0019426 name: bisulfite reduction namespace: biological_process def: "The chemical reactions and pathways resulting in the reduction of sulfate to thiosulfate via bisulfite." [MetaCyc:P224-PWY] synonym: "bisulphite reduction" EXACT [] xref: MetaCyc:P224-PWY is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0019427 name: acetyl-CoA biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from acetate, either directly or via acetylphosphate." [MetaCyc:ACETATEUTIL-PWY] synonym: "acetate utilization" RELATED [] synonym: "acetyl-CoA anabolism from acetate" EXACT [] synonym: "acetyl-CoA formation from acetate" EXACT [] synonym: "acetyl-CoA synthesis from acetate" EXACT [] xref: MetaCyc:ACETATEUTIL-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019428 name: allantoin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:go_curators] synonym: "allantoin anabolism" EXACT [] synonym: "allantoin biosynthesis" EXACT [] synonym: "allantoin formation" EXACT [] synonym: "allantoin synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019429 name: fluorene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fluorene, a tricyclic polycyclic aromatic hydrocarbon containing a five-membered ring. It is a major component of fossil fuels and their derivatives and is also a by-product of coal-conversion and energy-related industries. It is commonly found in vehicle exhaust emissions, crude oils, motor oils, coal and oil combustion products, waste incineration, and industrial effluents." [GOC:go_curators] synonym: "fluorene breakdown" EXACT [] synonym: "fluorene catabolism" EXACT [] synonym: "fluorene degradation" EXACT [] xref: MetaCyc:FLUORENE-DEG-9-ONE-PWY is_a: GO:0018917 ! fluorene metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019430 name: removal of superoxide radicals namespace: biological_process def: "Any process, acting at the cellular level, involved in removing superoxide radicals (O2-) from a cell or organism, e.g. by conversion to dioxygen (O2) and hydrogen peroxide (H2O2)." [CHEBI:18421, GOC:jl] synonym: "cellular detoxification of superoxide radicals" EXACT [GOC:dos] synonym: "removal of O2-" EXACT [] synonym: "removal of oxygen free radicals" EXACT [] xref: MetaCyc:DETOX1-PWY is_a: GO:0006801 ! superoxide metabolic process is_a: GO:0098869 ! cellular oxidant detoxification relationship: part_of GO:0071451 ! cellular response to superoxide [Term] id: GO:0019431 name: acetyl-CoA biosynthetic process from ethanol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from ethanol via acetaldehyde." [GOC:go_curators] synonym: "acetyl-CoA anabolism from ethanol" EXACT [] synonym: "acetyl-CoA formation from ethanol" EXACT [] synonym: "acetyl-CoA synthesis from ethanol" EXACT [] xref: MetaCyc:ETOH-ACETYLCOA-ANA-PWY is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0006085 ! acetyl-CoA biosynthetic process [Term] id: GO:0019432 name: triglyceride biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a triglyceride, any triester of glycerol." [ISBN:0198506732] synonym: "triacylglycerol biosynthesis" EXACT [] synonym: "triacylglycerol biosynthetic process" EXACT [] synonym: "triglyceride anabolism" EXACT [] synonym: "triglyceride biosynthesis" EXACT [] synonym: "triglyceride formation" EXACT [] synonym: "triglyceride synthesis" EXACT [] xref: MetaCyc:TRIGLSYN-PWY is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0019433 name: triglyceride catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a triglyceride, any triester of glycerol." [ISBN:0198506732] synonym: "triacylglycerol catabolic process" EXACT [] synonym: "triacylglycerol catabolism" EXACT [] synonym: "triglyceride breakdown" EXACT [] synonym: "triglyceride catabolism" EXACT [] synonym: "triglyceride degradation" EXACT [] xref: MetaCyc:LIPAS-PWY is_a: GO:0006641 ! triglyceride metabolic process is_a: GO:0046464 ! acylglycerol catabolic process [Term] id: GO:0019434 name: sophorosyloxydocosanoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate, an aromatic hydrocarbon." [MetaCyc:DIGLUCODIACETYL-DOCOSANOATE] synonym: "sophorosyloxydocosanoate metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process [Term] id: GO:0019435 name: sophorosyloxydocosanoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] synonym: "sophorosyloxydocosanoate anabolism" EXACT [] synonym: "sophorosyloxydocosanoate biosynthesis" EXACT [] synonym: "sophorosyloxydocosanoate formation" EXACT [] synonym: "sophorosyloxydocosanoate synthesis" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-SYN-PWY is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process [Term] id: GO:0019436 name: sophorosyloxydocosanoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sophorosyloxydocosanoate, 13-sophorosyloxydocosanoate 6',6''-diacetate." [GOC:ai] synonym: "sophorosyloxydocosanoate breakdown" EXACT [] synonym: "sophorosyloxydocosanoate catabolism" EXACT [] synonym: "sophorosyloxydocosanoate degradation" EXACT [] xref: MetaCyc:SOPHOROSYLOXYDOCOSANOATE-DEG-PWY is_a: GO:0019377 ! glycolipid catabolic process is_a: GO:0019434 ! sophorosyloxydocosanoate metabolic process [Term] id: GO:0019438 name: aromatic compound biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound anabolism" EXACT [] synonym: "aromatic compound biosynthesis" EXACT [] synonym: "aromatic compound formation" EXACT [] synonym: "aromatic compound synthesis" EXACT [] synonym: "aromatic hydrocarbon biosynthesis" NARROW [] synonym: "aromatic hydrocarbon biosynthetic process" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019439 name: aromatic compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring." [GOC:ai] synonym: "aromatic compound breakdown" EXACT [] synonym: "aromatic compound catabolism" EXACT [] synonym: "aromatic compound degradation" EXACT [] synonym: "aromatic hydrocarbon catabolic process" NARROW [] synonym: "aromatic hydrocarbon catabolism" NARROW [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0019440 name: tryptophan catabolic process to indole-3-acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including indole-3-acetate." [GOC:go_curators] synonym: "tryptophan breakdown to indole-3-acetate" EXACT [] synonym: "tryptophan catabolic process to IAA" EXACT [] synonym: "tryptophan catabolic process to indoleacetic acid" EXACT [] synonym: "tryptophan catabolism to indoleacetic acid" EXACT [] synonym: "tryptophan degradation to indole-3-acetate" EXACT [] xref: MetaCyc:TRPIAACAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009683 ! indoleacetic acid metabolic process [Term] id: GO:0019441 name: tryptophan catabolic process to kynurenine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine." [GOC:go_curators] synonym: "tryptophan breakdown to kynurenine" EXACT [] synonym: "tryptophan degradation to kynurenine" EXACT [] xref: MetaCyc:TRPKYNCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0070189 ! kynurenine metabolic process [Term] id: GO:0019442 name: tryptophan catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including acetyl-CoA." [GOC:go_curators] synonym: "tryptophan breakdown to acetyl-CoA" EXACT [] synonym: "tryptophan degradation to acetyl-CoA" EXACT [] xref: MetaCyc:TRYPTOPHAN-DEGRADATION-1 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0006569 ! tryptophan catabolic process [Term] id: GO:0019443 name: obsolete tryptophan catabolic process, using tryptophanase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tryptophan, catalyzed by the enzyme tryptophanase (EC:4.1.99.1)." [GOC:jl] comment: This term was made obsolete because it refers to a one-step pathway. synonym: "tryptophan breakdown, using tryptophanase" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" EXACT [] synonym: "tryptophan degradation, using tryptophanase" EXACT [] is_obsolete: true consider: GO:0006569 consider: GO:0009034 [Term] id: GO:0019444 name: tryptophan catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including catechol." [GOC:go_curators] synonym: "tryptophan breakdown to catechol" EXACT [] synonym: "tryptophan degradation to catechol" EXACT [] xref: MetaCyc:TRPCAT-PWY is_a: GO:0006569 ! tryptophan catabolic process is_a: GO:0009712 ! catechol-containing compound metabolic process [Term] id: GO:0019445 name: tyrosine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including fumarate." [GOC:go_curators] synonym: "tyrosine breakdown to fumarate" EXACT [] synonym: "tyrosine degradation to fumarate" EXACT [] xref: MetaCyc:TYRFUMCAT-PWY is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006572 ! tyrosine catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019446 name: obsolete tyrosine catabolic process to phosphoenolpyruvate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of tyrosine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] comment: The reason for obsoletion is that there is no evidence that this is a real process. synonym: "tyrosine breakdown to phosphoenolpyruvate" EXACT [] synonym: "tyrosine degradation to phosphoenolpyruvate" EXACT [] is_obsolete: true [Term] id: GO:0019447 name: D-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-cysteine, (S)-2-amino-3-mercaptopropanoic acid, which occurs naturally in firefly luciferin." [GOC:go_curators, ISBN:0198506732] synonym: "D-cysteine breakdown" EXACT [] synonym: "D-cysteine catabolism" EXACT [] synonym: "D-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046438 ! D-cysteine metabolic process [Term] id: GO:0019448 name: L-cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, the L-enantiomer of 2-amino-3-mercaptopropanoic acid, i.e. (2R)-2-amino-3-mercaptopropanoic acid." [CHEBI:17561, GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-cysteine breakdown" EXACT [] synonym: "L-cysteine catabolism" EXACT [] synonym: "L-cysteine degradation" EXACT [] is_a: GO:0009093 ! cysteine catabolic process is_a: GO:0046439 ! L-cysteine metabolic process [Term] id: GO:0019449 name: L-cysteine catabolic process to hypotaurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including hypotaurine." [GOC:go_curators] synonym: "L-cysteine breakdown to hypotaurine" EXACT [] synonym: "L-cysteine degradation to hypotaurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019450 name: L-cysteine catabolic process to pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including pyruvate." [GOC:go_curators] synonym: "L-cysteine breakdown to pyruvate" EXACT [] synonym: "L-cysteine degradation to pyruvate" EXACT [] xref: MetaCyc:LCYSDEG-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019451 name: L-cysteine catabolic process to pyruvate, using cysteine dioxygenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown into pyruvate of L-cystine, catalyzed by the enzyme cysteine dioxygenase (EC:1.13.11.20)." [GOC:jl] synonym: "L-cysteine breakdown to pyruvate, using cysteine dioxygenase" EXACT [] synonym: "L-cysteine degradation to pyruvate, using cysteine dioxygenase" EXACT [] xref: MetaCyc:CYSTEINE-DEG-PWY is_a: GO:0019450 ! L-cysteine catabolic process to pyruvate [Term] id: GO:0019452 name: L-cysteine catabolic process to taurine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine into other compounds, including taurine." [GOC:go_curators] synonym: "L-cysteine breakdown to taurine" EXACT [] synonym: "L-cysteine degradation to taurine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process is_a: GO:0019530 ! taurine metabolic process [Term] id: GO:0019453 name: L-cysteine catabolic process via cystine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-cysteine, via the intermediate cystine." [GOC:go_curators] synonym: "L-cysteine breakdown via cystine" EXACT [] synonym: "L-cysteine degradation via cystine" EXACT [] is_a: GO:0019448 ! L-cysteine catabolic process [Term] id: GO:0019454 name: L-cysteine catabolic process via cystine, using glutathione-cystine transhydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme glutathione-cystine transhydrogenase (EC:1.8.4.4)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using glutathione-cystine transhydrogenase" EXACT [] synonym: "L-cysteine degradation via cystine, using glutathione-cystine transhydrogenase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019455 name: L-cysteine catabolic process via cystine, using cystine reductase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cystine reductase (EC:1.8.1.6)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using cystine reductase" EXACT [] synonym: "L-cysteine degradation via cystine, using cystine reductase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019456 name: L-cysteine catabolic process via cystine, using cysteine transaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown, via the compound cystine, of L-cysteine, catalyzed by the enzyme cysteine transaminase (EC:2.6.1.3)." [GOC:jl] synonym: "L-cysteine breakdown via cystine, using cysteine transaminase" EXACT [] synonym: "L-cysteine degradation via cystine, using cysteine transaminase" EXACT [] is_a: GO:0019453 ! L-cysteine catabolic process via cystine [Term] id: GO:0019457 name: methionine catabolic process to succinyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine into other compounds, including succinyl-CoA." [GOC:go_curators] synonym: "methionine breakdown to succinyl-CoA" EXACT [] synonym: "methionine degradation to succinyl-CoA" EXACT [] xref: MetaCyc:METHIONINE-DEG1-PWY is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019458 name: methionine catabolic process via 2-oxobutanoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine, via the intermediate 2-oxobutanoate." [GOC:go_curators] synonym: "methionine breakdown via 2-oxobutanoate" EXACT [] synonym: "methionine degradation via 2-oxobutanoate" EXACT [] xref: MetaCyc:PWY-701 is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0019460 name: glutamine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into other compounds, including fumarate." [GOC:go_curators] synonym: "glutamate catabolic process to fumarate" NARROW [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate" EXACT [] synonym: "glutamine degradation to fumarate" EXACT [] is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0006543 ! glutamine catabolic process [Term] id: GO:0019461 name: glutamine catabolic process to fumarate, using glutamate synthase (NADPH) namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with the conversion of glutamine to glutamate catalyzed by the enzyme glutamate synthase (NADPH) (EC:1.4.1.13)." [GOC:bf, GOC:jl] synonym: "glutamate catabolic process to fumarate, using glutamate synthase (NADPH)" RELATED [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate, using glutamate synthase (NADPH)" EXACT [] synonym: "glutamine degradation to fumarate, using glutamate synthase (NADPH)" EXACT [] xref: MetaCyc:GLUTAMINEFUM-PWY is_a: GO:0019460 ! glutamine catabolic process to fumarate [Term] id: GO:0019462 name: glutamine catabolic process to fumarate, using glutaminase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine into fumarate, beginning with conversion of glutamine into glutamate catalyzed by the enzyme glutaminase (EC:3.5.1.2)." [GOC:bf, GOC:jl] synonym: "glutamate catabolic process to fumarate, using glutaminase" RELATED [GOC:bf, GOC:jl] synonym: "glutamine breakdown to fumarate, using glutaminase" EXACT [] synonym: "glutamine degradation to fumarate, using glutaminase" NARROW [] xref: MetaCyc:GLUTAMINDEG-PWY is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019463 name: glycine catabolic process to creatine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine into other compounds, including creatine." [GOC:go_curators] synonym: "glycine breakdown to creatine" EXACT [] synonym: "glycine degradation to creatine" EXACT [] xref: MetaCyc:GLYCGREAT-PWY is_a: GO:0006546 ! glycine catabolic process is_a: GO:0006600 ! creatine metabolic process [Term] id: GO:0019464 name: glycine decarboxylation via glycine cleavage system namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex." [MetaCyc:GLYCLEAV-PWY] synonym: "glycine cleavage system" BROAD [] xref: MetaCyc:GLYCLEAV-PWY is_a: GO:0006546 ! glycine catabolic process [Term] id: GO:0019465 name: aspartate transamidation namespace: biological_process def: "The exchange of the amino group of aspartate, the anion derived from aspartic acid, for another amino group." [GOC:go_curators, ISBN:0198506732] xref: MetaCyc:ASPARTATE-DEG1-PWY xref: MetaCyc:ASPARTATESYN-PWY is_a: GO:0006533 ! aspartate catabolic process [Term] id: GO:0019466 name: ornithine catabolic process via proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, via the intermediate proline." [GOC:go_curators] synonym: "ornithine breakdown via proline" EXACT [] synonym: "ornithine degradation via proline" EXACT [] xref: MetaCyc:ORN-AMINOPENTANOATE-CAT-PWY is_a: GO:0006560 ! proline metabolic process is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019467 name: ornithine catabolic process, by decarboxylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine by decarboxylation." [GOC:go_curators] synonym: "ornithine breakdown, by decarboxylation" EXACT [] synonym: "ornithine degradation, by decarboxylation" EXACT [] xref: MetaCyc:ORNDEG-PWY is_a: GO:0006593 ! ornithine catabolic process [Term] id: GO:0019468 name: nopaline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nopaline (N-(I-carboxy-4-guanidinobutyl)glutamic acid), a rare amino-acid derivative." [GOC:jl, ISBN:0198506732] synonym: "nopaline breakdown" EXACT [] synonym: "nopaline catabolism" EXACT [] synonym: "nopaline degradation" EXACT [] xref: MetaCyc:NOPALINEDEG-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0046418 ! nopaline metabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019469 name: octopine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of octopine (N-(1-carboxy-4-guanidinobutyl)-L-alanine), an amino acid derived opine." [GOC:jl, ISBN:0198506732] synonym: "octopine breakdown" EXACT [] synonym: "octopine catabolism" EXACT [] synonym: "octopine degradation" EXACT [] xref: MetaCyc:OCTOPINEDEG-PWY is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process is_a: GO:0046419 ! octopine metabolic process [Term] id: GO:0019470 name: 4-hydroxyproline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] synonym: "4-hydroxyproline breakdown" EXACT [] synonym: "4-hydroxyproline catabolism" EXACT [] synonym: "4-hydroxyproline degradation" EXACT [] xref: MetaCyc:HYDROXYPRODEG-PWY is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019471 name: 4-hydroxyproline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline. The presence of hydroxyproline is essential to produce stable triple helical tropocollagen, hence the problems caused by ascorbate deficiency in scurvy. This unusual amino acid is also present in considerable amounts in the major glycoprotein of primary plant cell walls." [CHEBI:20392, GOC:ai] synonym: "4-hydroxyproline metabolism" EXACT [] is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0019472 name: 4-hydroxyproline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 4-hydroxyproline, C5H9NO3, a derivative of the amino acid proline." [GOC:ai] synonym: "4-hydroxyproline anabolism" EXACT [] synonym: "4-hydroxyproline biosynthesis" EXACT [] synonym: "4-hydroxyproline formation" EXACT [] synonym: "4-hydroxyproline synthesis" EXACT [] is_a: GO:0019471 ! 4-hydroxyproline metabolic process is_a: GO:0042398 ! cellular modified amino acid biosynthetic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019473 name: L-lysine catabolic process to glutarate, by acetylation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including glutarate, by acetylation." [GOC:go_curators] synonym: "L-lysine breakdown to glutarate, by acetylation" EXACT [] synonym: "L-lysine degradation to glutarate, by acetylation" EXACT [] xref: MetaCyc:LYSDEGII-PWY is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019474 name: L-lysine catabolic process to acetyl-CoA namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetyl-CoA." [GOC:go_curators] synonym: "L-lysine breakdown to acetyl-CoA" EXACT [] synonym: "L-lysine degradation to acetyl-CoA" EXACT [] is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0019477 ! L-lysine catabolic process [Term] id: GO:0019475 name: L-lysine catabolic process to acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine into other compounds, including acetate." [GOC:go_curators] synonym: "L-lysine breakdown to acetate" EXACT [] synonym: "L-lysine degradation to acetate" EXACT [] synonym: "lysine fermentation" EXACT [] xref: MetaCyc:P163-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0019477 ! L-lysine catabolic process is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019476 name: D-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-lysine, the D-enantiomer of lysine; i.e. (2R)-2,6-diaminohexanoic acid." [CHEBI:16855, GOC:ai, GOC:jsg, GOC:mah] synonym: "D-lysine breakdown" EXACT [] synonym: "D-lysine catabolism" EXACT [] synonym: "D-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0019478 ! D-amino acid catabolic process is_a: GO:0046441 ! D-lysine metabolic process [Term] id: GO:0019477 name: L-lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-lysine, the L-enantiomer of (S)-2,6-diaminohexanoic acid." [GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-lysine breakdown" EXACT [] synonym: "L-lysine catabolism" EXACT [] synonym: "L-lysine degradation" EXACT [] is_a: GO:0006554 ! lysine catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046440 ! L-lysine metabolic process [Term] id: GO:0019478 name: D-amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids." [GOC:ai, GOC:jsg] synonym: "D-amino acid breakdown" EXACT [] synonym: "D-amino acid catabolism" EXACT [] synonym: "D-amino acid degradation" EXACT [] is_a: GO:0046416 ! D-amino acid metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019479 name: L-alanine oxidation to D-lactate and ammonia namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to D-lactate and ammonia." [MetaCyc:ALACAT2-PWY] xref: MetaCyc:ALACAT2-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019480 name: L-alanine oxidation to pyruvate via D-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine to pyruvate, with D-alanine as an intermediate." [MetaCyc:ALADEG-PWY] xref: MetaCyc:ALADEG-PWY is_a: GO:0042853 ! L-alanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019481 name: L-alanine catabolic process, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-alanine by transamination." [GOC:go_curators] synonym: "L-alanine breakdown, by transamination" EXACT [] synonym: "L-alanine degradation, by transamination" EXACT [] xref: MetaCyc:ALANINE-DEG3-PWY is_a: GO:0042853 ! L-alanine catabolic process [Term] id: GO:0019482 name: beta-alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine metabolism" EXACT [] xref: Wikipedia:Beta-alanine is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0042133 ! neurotransmitter metabolic process [Term] id: GO:0019483 name: beta-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine anabolism" EXACT [] synonym: "beta-alanine biosynthesis" EXACT [] synonym: "beta-alanine formation" EXACT [] synonym: "beta-alanine synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0019482 ! beta-alanine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process [Term] id: GO:0019484 name: beta-alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine (3-aminopropanoic acid), an achiral amino acid and an isomer of alanine. It occurs free (e.g. in brain) and in combination (e.g. in pantothenate) but it is not a constituent of proteins." [GOC:jl, ISBN:0198506732] synonym: "beta-alanine breakdown" EXACT [] synonym: "beta-alanine catabolism" EXACT [] synonym: "beta-alanine degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019482 ! beta-alanine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process [Term] id: GO:0019485 name: beta-alanine catabolic process to L-alanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including L-alanine." [GOC:go_curators] synonym: "beta-alanine breakdown to L-alanine" EXACT [] synonym: "beta-alanine degradation to L-alanine" EXACT [] is_a: GO:0019484 ! beta-alanine catabolic process is_a: GO:0042851 ! L-alanine metabolic process [Term] id: GO:0019486 name: beta-alanine catabolic process to mevalonate semialdehyde, by transamination namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-alanine into other compounds, including mevalonate semialdehyde, by transamination." [GOC:go_curators] synonym: "beta-alanine breakdown to mevalonate semialdehyde, by transamination" EXACT [] synonym: "beta-alanine degradation to mevalonate semialdehyde, by transamination" EXACT [] xref: MetaCyc:BETA-ALA-DEGRADATION-I-PWY is_a: GO:0019484 ! beta-alanine catabolic process [Term] id: GO:0019487 name: anaerobic acetylene catabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylene, a colorless, volatile, explosive gas, that occur in the absence of oxygen." [ISBN:0721662544] synonym: "anaerobic acetylene breakdown" EXACT [] synonym: "anaerobic acetylene catabolism" EXACT [] synonym: "anaerobic acetylene degradation" EXACT [] synonym: "anaerobic ethyne catabolic process" EXACT [] synonym: "anaerobic ethyne catabolism" EXACT [] xref: MetaCyc:P161-PWY is_a: GO:0018864 ! acetylene metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0043454 ! alkyne catabolic process [Term] id: GO:0019488 name: ribitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ribitol to form xylulose 5-phosphate. Ribitol is initially converted to D-ribulose, which is phosphorylated to form ribulose 5-phosphate, which is then converted into xylulose 5-phosphate." [MetaCyc:RIBITOLUTIL-PWY] synonym: "ribitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "ribitol degradation to xylulose 5-phosphate" EXACT [] synonym: "ribitol utilization" RELATED [] xref: MetaCyc:RIBITOLUTIL-PWY is_a: GO:0046363 ! ribitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019489 name: methylgallate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylgallate, trihydroxymethylbenzoate, the anion of methylgallic acid." [GOC:ai] synonym: "methylgallate metabolism" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0019490 name: 2-aminobenzenesulfonate desulfonation namespace: biological_process def: "The removal of the sulfonate group from 2-aminobenzenesulfonate, an aromatic sulfonate used in organic synthesis and in the manufacture of various dyes and medicines." [UM-BBD_pathwayID:abs] synonym: "2-aminobenzenesulphonate desulphonation" EXACT [] xref: MetaCyc:2ASDEG-PWY is_a: GO:0018868 ! 2-aminobenzenesulfonate metabolic process [Term] id: GO:0019491 name: ectoine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidinecarboxylic acid), a tetrahydropyrimidine commonly synthesized by halophilic bacteria." [GOC:jl, PMID:11823218] synonym: "ectoine anabolism" EXACT [] synonym: "ectoine biosynthesis" EXACT [] synonym: "ectoine formation" EXACT [] synonym: "ectoine synthesis" EXACT [] xref: MetaCyc:P101-PWY is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042399 ! ectoine metabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019492 name: proline salvage namespace: biological_process def: "Any process which produces the amino acid proline from derivatives of it, without de novo synthesis." [GOC:jl] synonym: "proline cycling" EXACT [] is_a: GO:0006561 ! proline biosynthetic process is_a: GO:0043102 ! amino acid salvage [Term] id: GO:0019493 name: arginine catabolic process to proline namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline." [GOC:go_curators] synonym: "arginine breakdown to proline" EXACT [] synonym: "arginine degradation to proline" EXACT [] xref: MetaCyc:ARG-PRO-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006560 ! proline metabolic process [Term] id: GO:0019495 name: proline catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "proline breakdown to 2-oxoglutarate" EXACT [] synonym: "proline catabolic process to 2-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-ketoglutarate" EXACT [] synonym: "proline catabolic process to alpha-oxoglutarate" EXACT [] synonym: "proline catabolism to 2-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-ketoglutarate" EXACT [] synonym: "proline catabolism to alpha-oxoglutarate" EXACT [] synonym: "proline degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0019496 name: serine-isocitrate lyase pathway namespace: biological_process def: "A one-carbon metabolic process in which acetyl-CoA is produced from formaldehyde and carbon dioxide." [ISBN:0387961534] is_a: GO:0006730 ! one-carbon metabolic process [Term] id: GO:0019497 name: hexachlorocyclohexane metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexachlorocyclohexane, a cyclohexane derivative with 6 chlorine atoms attached to the hexane ring. Hexachlorocyclohexane consists of a mixture of 8 different isomers and was used a commercial insecticide. It is persistent in the environment, causing serious soil pollution." [UM-BBD_pathwayID:ghch, UM-BBD_pathwayID:hch] synonym: "hexachlorocyclohexane metabolism" EXACT [] is_a: GO:0042196 ! chlorinated hydrocarbon metabolic process [Term] id: GO:0019498 name: n-octane oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of n-octane to octanoyl-CoA." [MetaCyc:P221-PWY] xref: MetaCyc:P221-PWY is_a: GO:0018939 ! n-octane metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019499 name: cyanide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration, reacting with the ferric form of cytochrome aa3 and thus blocking the electron transport chain." [ISBN:0198506732] synonym: "cyanide metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019500 name: cyanide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration." [ISBN:0198506732] synonym: "cyanide breakdown" EXACT [] synonym: "cyanide catabolism" EXACT [] synonym: "cyanide degradation" EXACT [] xref: MetaCyc:P401-PWY is_a: GO:0019499 ! cyanide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0019501 name: arsonoacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arsonoacetate, a synthetic, organic compound containing a single arsenic atom." [GOC:jl] synonym: "arsonoacetate breakdown" EXACT [] synonym: "arsonoacetate catabolism" EXACT [] synonym: "arsonoacetate degradation" EXACT [] xref: MetaCyc:P482-PWY is_a: GO:0018872 ! arsonoacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019502 name: stachydrine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline found in alfalfa, chrysanthemum, and citrus plants." [GOC:curators, MetaCyc:CPD-821] synonym: "stachydrine metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901605 ! alpha-amino acid metabolic process [Term] id: GO:0019503 name: stachydrine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] synonym: "stachydrine anabolism" EXACT [] synonym: "stachydrine biosynthesis" EXACT [] synonym: "stachydrine formation" EXACT [] synonym: "stachydrine synthesis" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:1901607 ! alpha-amino acid biosynthetic process [Term] id: GO:0019504 name: stachydrine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of stachydrine, N-methylproline methylbetaine, the betaine derivative of L-proline." [GOC:ai] synonym: "stachydrine breakdown" EXACT [] synonym: "stachydrine catabolism" EXACT [] synonym: "stachydrine degradation" EXACT [] xref: MetaCyc:P561-PWY is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0009822 ! alkaloid catabolic process is_a: GO:0019502 ! stachydrine metabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019505 name: resorcinol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving resorcinol (C6H4(OH)2), a benzene derivative with many applications, including dyes, explosives, resins and as an antiseptic." [GOC:jl, http://www.speclab.com/compound/c108463.htm] synonym: "1,3-benzenediol metabolic process" EXACT [] synonym: "1,3-benzenediol metabolism" EXACT [] synonym: "1,3-dihydroxybenzene metabolic process" EXACT [] synonym: "1,3-dihydroxybenzene metabolism" EXACT [] synonym: "resorcinol metabolism" EXACT [] xref: MetaCyc:P343-PWY is_a: GO:0018958 ! phenol-containing compound metabolic process [Term] id: GO:0019506 name: phenylmercury acetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylmercury acetate, an organomercurial compound composed of a mercury atom attached to a benzene ring and an acetate group." [GOC:ai] synonym: "phenylmercury acetate breakdown" EXACT [] synonym: "phenylmercury acetate catabolism" EXACT [] synonym: "phenylmercury acetate degradation" EXACT [] xref: MetaCyc:P641-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046412 ! phenylmercury acetate metabolic process is_a: GO:0046413 ! organomercury catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019507 name: pyridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyridine, a nitrogenous base (C5H5N) obtained from the distillation of bone oil or coal tar, and by the decomposition of certain alkaloids, as a colorless liquid with a peculiar pungent odor." [CHEBI:16227, GOC:curators] synonym: "pyridine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072524 ! pyridine-containing compound metabolic process [Term] id: GO:0019508 name: 2,5-dihydroxypyridine catabolic process to fumarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2,5-dihydroxypyridine to form fumarate. 2,5-dihydroxypyridine is dioxygenated to give maleamate and formate; the maleamate from this reaction is then converted to maleate, which is then isomerized to fumurate." [MetaCyc:PWY-722] synonym: "2,5-dihydroxypyridine breakdown to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine degradation to fumarate" EXACT [] synonym: "2,5-dihydroxypyridine utilization" RELATED [] synonym: "maleamate pathway" EXACT [] synonym: "pyridine-2,5-diol catabolic process to fumarate" EXACT [CHEBI:16364] xref: MetaCyc:PWY-722 is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0051166 ! 2,5-dihydroxypyridine catabolic process [Term] id: GO:0019509 name: L-methionine salvage from methylthioadenosine namespace: biological_process def: "The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine." [GOC:jl, MetaCyc:PWY-4361] synonym: "methionine recycling" NARROW [] synonym: "methionine regeneration" NARROW [] synonym: "methionine salvage from methylthioadenosine" EXACT [GOC:mah] synonym: "methionine salvage pathway" EXACT [] xref: MetaCyc:PWY-4361 is_a: GO:0071267 ! L-methionine salvage [Term] id: GO:0019510 name: S-adenosylhomocysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of S-adenosylhomocysteine, forming homocysteine and then methionine." [ISBN:0198506732] synonym: "S-adenosylhomocysteine breakdown" EXACT [] synonym: "S-adenosylhomocysteine catabolism" EXACT [] synonym: "S-adenosylhomocysteine degradation" EXACT [] xref: MetaCyc:ADENOSYLHOMOCYSCAT-PWY is_a: GO:0042219 ! cellular modified amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process is_a: GO:0046498 ! S-adenosylhomocysteine metabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901606 ! alpha-amino acid catabolic process [Term] id: GO:0019511 name: peptidyl-proline hydroxylation namespace: biological_process alt_id: GO:0006472 def: "The hydroxylation of peptidyl-proline to form peptidyl-hydroxyproline." [GOC:mah] is_a: GO:0018126 ! protein hydroxylation is_a: GO:0018208 ! peptidyl-proline modification [Term] id: GO:0019512 name: lactose catabolic process via tagatose-6-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate tagatose-6-phosphate." [GOC:go_curators] synonym: "lactose breakdown via tagatose-6-phosphate" EXACT [] synonym: "lactose degradation via tagatose-6-phosphate" EXACT [] xref: MetaCyc:LACTOSECAT-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019513 name: lactose catabolic process, using glucoside 3-dehydrogenase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, catalyzed by the enzyme glucoside 3-dehydrogenase (EC:1.1.99.13)." [GOC:jl] synonym: "lactose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "lactose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:LACTOSEUTIL-PWY is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019514 name: obsolete lactose hydrolysis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction. synonym: "lactose hydrolysis" EXACT [] is_obsolete: true consider: GO:0004565 [Term] id: GO:0019515 name: lactose catabolic process via UDP-galactose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, via the intermediate UDP-galactose." [GOC:go_curators] synonym: "lactose breakdown via UDP-galactose" EXACT [] synonym: "lactose degradation via UDP-galactose" EXACT [] is_a: GO:0005990 ! lactose catabolic process [Term] id: GO:0019516 name: lactate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of lactate to other compounds, such as pyruvate, with concomitant loss of electrons." [GOC:mah] is_a: GO:0006089 ! lactate metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019517 name: L-threonine catabolic process to D-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L- threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form the compound methylglyoxal, which is subsequently converted to D-lactate." [GOC:bf, GOC:jl, MetaCyc:PWY-901, MetaCyc:THRDLCTCAT-PWY] synonym: "L-threonine breakdown to D-lactate" EXACT [GOC:bf] synonym: "L-threonine catabolic process to (R)-lactate" BROAD [CHEBI:16004, GOC:bf] synonym: "L-threonine catabolic process to methylglyoxal" EXACT [MetaCyc:THRDLCTCAT-PWY] synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to D-lactate" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to D-lactate" EXACT [GOC:bf] synonym: "threonine catabolic process to D-lactate" BROAD [GOC:bf] xref: MetaCyc:THRDLCTCAT-PWY is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006567 ! threonine catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019518 name: L-threonine catabolic process to glycine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-threonine (the L-enantiomer of 2-amino-3-hydroxybutyric acid) to form to form 2-amino-3-oxobutanoate, which is subsequently converted to glycine." [GOC:bf, GOC:mah, MetaCyc:THREONINE-DEG2-PWY] synonym: "L-threonine breakdown to glycine" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine catabolic process to pyruvate" RELATED [GOC:bf, GOC:mah] synonym: "L-threonine catabolism to glycine" EXACT [GOC:bf, GOC:mah] synonym: "L-threonine degradation to glycine" EXACT [GOC:bf, GOC:mah] synonym: "threonine catabolic process to glycine" BROAD [GOC:bf] xref: MetaCyc:THREONINE-DEG2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0006567 ! threonine catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019519 name: pentitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0019520 name: aldonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldonic acid, a monocarboxylic acid with a chain of three or more carbon atoms, derived from an aldose by oxidation of the aldehydic group." [ISBN:0198506732] synonym: "aldonic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0019521 name: D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-gluconate, the anion of D-gluconic acid, the aldonic acid derived from glucose." [ISBN:0198506732] synonym: "D-gluconate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019522 name: ketogluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ketogluconate, the anion of ketogluconic acid, an aldonic acid derived from glucose containing a ketonic carbonyl group." [ISBN:0198506732] synonym: "ketogluconate metabolism" EXACT [] xref: MetaCyc:KETOGLUCONMET-PWY is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019523 name: L-idonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-idonate, the anion of idonic acid, an aldonic acid derived from L-idose, an aldohexose which is epimeric with D-glucose." [CHEBI:17796, GOC:ai] synonym: "L-idonate metabolism" EXACT [] xref: MetaCyc:IDNCAT-PWY is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019524 name: keto-D-gluconate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] synonym: "keto-D-gluconate breakdown" EXACT [] synonym: "keto-D-gluconate catabolism" EXACT [] synonym: "keto-D-gluconate degradation" EXACT [] xref: MetaCyc:DHGLUCONATE-PYR-CAT-PWY is_a: GO:0019525 ! keto-D-gluconate metabolic process is_a: GO:0046181 ! ketogluconate catabolic process [Term] id: GO:0019525 name: keto-D-gluconate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving keto-D-gluconate, the anion of keto-D-gluconic acid, an aldonic acid derived from glucose." [ISBN:0198506732] synonym: "keto-D-gluconate metabolism" EXACT [] is_a: GO:0019522 ! ketogluconate metabolic process [Term] id: GO:0019526 name: pentitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol anabolism" EXACT [] synonym: "pentitol biosynthesis" EXACT [] synonym: "pentitol formation" EXACT [] synonym: "pentitol synthesis" EXACT [] is_a: GO:0019401 ! alditol biosynthetic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019527 name: pentitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentitols, any alditol with a chain of five carbon atoms in the molecule." [ISBN:0198506732] synonym: "pentitol breakdown" EXACT [] synonym: "pentitol catabolism" EXACT [] synonym: "pentitol degradation" EXACT [] is_a: GO:0019405 ! alditol catabolic process is_a: GO:0019519 ! pentitol metabolic process [Term] id: GO:0019528 name: D-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabitol to form xylulose 5-phosphate. D-arabitol is converted into D-xylulose, which is then phosphorylated to form D-xylulose-5-phosphate." [MetaCyc:DARABITOLUTIL-PWY] synonym: "D-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol degradation" RELATED [] synonym: "D-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "D-arabitol utilization" RELATED [] xref: MetaCyc:DARABITOLUTIL-PWY is_a: GO:0051159 ! D-arabitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019529 name: taurine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine breakdown" EXACT [] synonym: "taurine catabolism" EXACT [] synonym: "taurine degradation" EXACT [] xref: MetaCyc:TAURINEDEG-PWY is_a: GO:0019530 ! taurine metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046306 ! alkanesulfonate catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019530 name: taurine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving taurine (2-aminoethanesulfonic acid), a sulphur-containing amino acid derivative important in the metabolism of fats." [GOC:jl, ISBN:0198600461] synonym: "taurine metabolism" EXACT [] is_a: GO:0006805 ! xenobiotic metabolic process is_a: GO:0019694 ! alkanesulfonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019531 name: oxalate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] synonym: "oxalic acid transporter activity" EXACT [] is_a: GO:0005310 ! dicarboxylic acid transmembrane transporter activity [Term] id: GO:0019532 name: oxalate transport namespace: biological_process def: "The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals." [ISBN:0198506732] synonym: "ethanedioate transport" EXACT [] synonym: "ethanedioic acid transport" EXACT [] synonym: "oxalic acid transport" EXACT [] is_a: GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0019533 name: cellobiose transport namespace: biological_process def: "The directed movement of cellobiose into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Cellobiose, or 4-O-beta-D-glucopyranosyl-D-glucose, is a disaccharide that represents the basic repeating unit of cellulose." [GOC:ai] is_a: GO:0015766 ! disaccharide transport [Term] id: GO:0019534 name: toxin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a toxin from one side of a membrane to the other. A toxin is a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [ISBN:0198506732] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0019535 name: ferric-vibriobactin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of ferric-vibriobactin ions from one side of a membrane to the other." [GOC:ai] is_a: GO:0015343 ! siderophore transmembrane transporter activity is_a: GO:0015603 ! iron chelate transmembrane transporter activity [Term] id: GO:0019536 name: vibriobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] synonym: "vibriobactin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009237 ! siderophore metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019537 name: vibriobactin biosynthetic process namespace: biological_process alt_id: GO:0031195 alt_id: GO:0031196 def: "The chemical reactions and pathways resulting in the formation of vibriobactin, the major siderophore produced by Vibrio cholerae." [GOC:jl, PMID:11112537] synonym: "vibriobactin anabolism" EXACT [] synonym: "vibriobactin biosynthesis" EXACT [] synonym: "vibriobactin biosynthetic process, peptide formation" NARROW [] synonym: "vibriobactin biosynthetic process, peptide modification" NARROW [] synonym: "vibriobactin formation" EXACT [] synonym: "vibriobactin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019536 ! vibriobactin metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019538 name: protein metabolic process namespace: biological_process alt_id: GO:0006411 alt_id: GO:0044268 def: "The chemical reactions and pathways involving a protein. Includes protein modification." [GOC:ma] subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pir subset: goslim_plant synonym: "multicellular organismal protein metabolic process" NARROW [] synonym: "protein metabolic process and modification" EXACT [] synonym: "protein metabolism" EXACT [] synonym: "protein metabolism and modification" EXACT [] xref: Wikipedia:Protein_metabolism is_a: GO:0043170 ! macromolecule metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019539 name: siderophore biosynthetic process from hydroxamic acid namespace: biological_process alt_id: GO:0031197 alt_id: GO:0031198 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including hydroxamic acid." [GOC:go_curators] synonym: "siderochrome biosynthesis from hydroxamic acid" NARROW [] synonym: "siderochrome biosynthetic process from hydroxamic acid" NARROW [] synonym: "siderophore anabolism from hydroxamic acid" EXACT [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from hydroxamic acid, peptide modification" NARROW [] synonym: "siderophore formation from hydroxamic acid" EXACT [] synonym: "siderophore synthesis from hydroxamic acid" EXACT [] is_a: GO:0019290 ! siderophore biosynthetic process is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019540 name: siderophore biosynthetic process from catechol namespace: biological_process alt_id: GO:0031189 alt_id: GO:0031190 def: "The chemical reactions and pathways resulting in the formation of a siderophore from other compounds, including catechol." [GOC:go_curators] synonym: "siderochrome biosynthesis from catechol" NARROW [] synonym: "siderochrome biosynthetic process from catechol" NARROW [] synonym: "siderophore anabolism from catechol" EXACT [] synonym: "siderophore biosynthetic process from catechol, peptide formation" NARROW [] synonym: "siderophore biosynthetic process from catechol, peptide modification" NARROW [] synonym: "siderophore formation from catechol" EXACT [] synonym: "siderophore synthesis from catechol" EXACT [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0019541 name: propionate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving propionate, the anion derived from propionic (propanoic) acid, a carboxylic acid important in the energy metabolism of ruminants." [GOC:go_curators, ISBN:0198506732, KEGG:C00163, MetaCyc:PROPIONATE] synonym: "propanoate metabolic process" EXACT [] synonym: "propanoate metabolism" EXACT [] synonym: "propionate metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019542 name: propionate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of propionate, the anion derived from propionic acid." [GOC:go_curators] synonym: "propionate anabolism" EXACT [] synonym: "propionate biosynthesis" EXACT [] synonym: "propionate formation" EXACT [] synonym: "propionate synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0051790 ! short-chain fatty acid biosynthetic process [Term] id: GO:0019543 name: propionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate, the anion derived from propionic acid." [GOC:go_curators] synonym: "propionate breakdown" EXACT [] synonym: "propionate catabolism" EXACT [] synonym: "propionate degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019626 ! short-chain fatty acid catabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019544 name: arginine catabolic process to glutamate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including glutamate." [GOC:go_curators] synonym: "arginine breakdown to glutamate" EXACT [] synonym: "arginine degradation to glutamate" EXACT [] xref: MetaCyc:ARG-GLU-PWY xref: MetaCyc:ARGASEDEG-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006536 ! glutamate metabolic process [Term] id: GO:0019545 name: arginine catabolic process to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including succinate." [GOC:go_curators] synonym: "arginine breakdown to succinate" EXACT [] synonym: "arginine degradation to succinate" EXACT [] xref: MetaCyc:ARGDEG-III-PWY xref: MetaCyc:ARGDEG-IV-PWY xref: MetaCyc:ARGDEG-V-PWY xref: MetaCyc:AST-PWY is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019546 name: arginine deiminase pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine and CO2, using the enzyme arginine deiminase." [GOC:mah, MetaCyc:ARGDEGRAD-PWY] xref: MetaCyc:ARGDEGRAD-PWY is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0019547 name: arginine catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including ornithine." [GOC:go_curators] synonym: "arginine breakdown to ornithine" EXACT [] synonym: "arginine degradation to ornithine" EXACT [] is_a: GO:0006527 ! arginine catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019548 name: arginine catabolic process to spermine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including spermine." [GOC:go_curators] synonym: "arginine breakdown to spermine" EXACT [] synonym: "arginine degradation to spermine" EXACT [] xref: MetaCyc:ARGSPECAT-PWY is_a: GO:0006527 ! arginine catabolic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0019549 name: glutamate catabolic process to succinate via succinate semialdehyde namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the pyruvate-dependent gamma aminobutyrate (GABA) transaminase." [GOC:bf, GOC:go_curators, MetaCyc:PWY-4321] comment: While mammals only have 2-oxoglutarate-dependent GABA-transaminase, both 2-oxoglutarate-dependent and pyruvate-dependent GABA-transaminase activities have been detected in plants. synonym: "glutamate breakdown to succinate" BROAD [] synonym: "glutamate catabolic process to succinate via pyruvate-dependent GABA-transaminase activity" EXACT [] synonym: "glutamate degradation to succinate" BROAD [] xref: MetaCyc:PWY-4321 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006540 ! glutamate decarboxylation to succinate [Term] id: GO:0019550 name: glutamate catabolic process to aspartate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including aspartate." [GOC:go_curators] synonym: "glutamate breakdown to aspartate" EXACT [] synonym: "glutamate degradation to aspartate" EXACT [] xref: MetaCyc:GLUTDEG-PWY is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019551 name: glutamate catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "glutamate breakdown to 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process to alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism to 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism to alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation to 2-oxoglutarate" EXACT [] xref: MetaCyc:GLUTAMATE-DEG1-PWY xref: MetaCyc:PWY-5766 is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006106 ! fumarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019552 name: glutamate catabolic process via 2-hydroxyglutarate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-hydroxyglutarate, yielding energy in the form of ATP." [MetaCyc:P162-PWY] synonym: "glutamate fermentation via 2-hydroxyglutarate" EXACT [] xref: MetaCyc:P162-PWY is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019553 name: glutamate catabolic process via L-citramalate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate L-citramalate." [GOC:go_curators] synonym: "glutamate breakdown via L-citramalate" EXACT [] synonym: "glutamate degradation via L-citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0019554 name: glutamate catabolic process to oxaloacetate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including oxaloacetate." [GOC:go_curators] synonym: "glutamate breakdown to oxaloacetate" EXACT [] synonym: "glutamate degradation to oxaloacetate" EXACT [] is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019555 name: glutamate catabolic process to ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate into other compounds, including ornithine." [GOC:go_curators] synonym: "glutamate breakdown to ornithine" EXACT [] synonym: "glutamate degradation to ornithine" EXACT [] xref: MetaCyc:GLUTORN-PWY is_a: GO:0006538 ! glutamate catabolic process is_a: GO:0006591 ! ornithine metabolic process [Term] id: GO:0019556 name: histidine catabolic process to glutamate and formamide namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formamide." [GOC:go_curators] synonym: "histidine breakdown to glutamate and formamide" EXACT [] synonym: "histidine degradation to glutamate and formamide" EXACT [] xref: MetaCyc:HISDEG-PWY is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process is_a: GO:0043606 ! formamide metabolic process [Term] id: GO:0019557 name: histidine catabolic process to glutamate and formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including glutamate and formate." [GOC:go_curators] synonym: "histidine breakdown to glutamate and formate" EXACT [] synonym: "histidine degradation to glutamate and formate" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006548 ! histidine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019558 name: histidine catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "histidine breakdown to 2-oxoglutarate" EXACT [] synonym: "histidine catabolic process to 2-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolic process to alpha-oxoglutarate" EXACT [] synonym: "histidine catabolism to 2-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-ketoglutarate" EXACT [] synonym: "histidine catabolism to alpha-oxoglutarate" EXACT [] synonym: "histidine degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019559 name: histidine catabolic process to imidazol-5-yl-lactate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including imidazol-5-yl-lactate." [GOC:go_curators] synonym: "histidine breakdown to imidazol-5-yl-lactate" EXACT [] synonym: "histidine degradation to imidazol-5-yl-lactate" EXACT [] xref: MetaCyc:HISTDEG-PWY is_a: GO:0006548 ! histidine catabolic process [Term] id: GO:0019560 name: histidine catabolic process to hydantoin-5-propionate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine into other compounds, including hydantoin-5-propionate." [GOC:go_curators] synonym: "histidine breakdown to hydantoin-5-propionate" EXACT [] synonym: "histidine degradation to hydantoin-5-propionate" EXACT [] xref: MetaCyc:HISHP-PWY is_a: GO:0006548 ! histidine catabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019561 name: anaerobic phenylalanine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine under anaerobic conditions; occurs via the intermediates phenylpyruvate and phenylacetaldehyde." [GOC:mah, MetaCyc:ANAPHENOXI-PWY] xref: MetaCyc:ANAPHENOXI-PWY is_a: GO:0006559 ! L-phenylalanine catabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019562 name: obsolete L-phenylalanine catabolic process to phosphoenolpyruvate namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-phenylalanine into other compounds, including phosphoenolpyruvate." [GOC:go_curators] comment: The reason for obsoletion is that there is no evidence that this is a real process. synonym: "phenylalanine breakdown to phosphoenolpyruvate" EXACT [] synonym: "phenylalanine degradation to phosphoenolpyruvate" EXACT [] xref: MetaCyc:PHENYLALANINE-DEG1-PWY is_obsolete: true [Term] id: GO:0019563 name: glycerol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:go_curators, ISBN:0198506732] synonym: "glycerol breakdown" EXACT [] synonym: "glycerol catabolism" EXACT [] synonym: "glycerol degradation" EXACT [] xref: MetaCyc:PWY-4261 xref: MetaCyc:PWY0-381 is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019405 ! alditol catabolic process [Term] id: GO:0019564 name: aerobic glycerol catabolic process namespace: biological_process alt_id: GO:0019565 def: "The chemical reactions and pathways resulting in the breakdown of glycerol, 1,2,3-propanetriol, in the presence of oxygen." [GOC:ai, ISBN:0198506732] synonym: "aerobic glycerol breakdown" EXACT [] synonym: "aerobic glycerol catabolism" EXACT [] synonym: "aerobic glycerol degradation" EXACT [] synonym: "aerobic glycerol fermentation" RELATED [] xref: MetaCyc:PWY0-381 is_a: GO:0019563 ! glycerol catabolic process [Term] id: GO:0019566 name: arabinose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinose, arabino-pentose. L-Arabinose occurs both free, for example in the heartwood of many conifers, and in the combined state, as a constituent of plant hemicelluloses, bacterial polysaccharides etc. D-arabinose is a constituent of arabinonucleosides." [ISBN:0198506732] synonym: "arabinose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0019567 name: arabinose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arabinose, arabino-pentose." [GOC:ai] synonym: "arabinose anabolism" EXACT [] synonym: "arabinose biosynthesis" EXACT [] synonym: "arabinose formation" EXACT [] synonym: "arabinose synthesis" EXACT [] is_a: GO:0019322 ! pentose biosynthetic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019568 name: arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinose, arabino-pentose." [GOC:ai] synonym: "arabinose breakdown" EXACT [] synonym: "arabinose catabolism" EXACT [] synonym: "arabinose degradation" EXACT [] is_a: GO:0019323 ! pentose catabolic process is_a: GO:0019566 ! arabinose metabolic process [Term] id: GO:0019569 name: L-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including xylulose 5-phosphate." [GOC:go_curators] synonym: "L-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:ARABCAT-PWY is_a: GO:0019572 ! L-arabinose catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019570 name: L-arabinose catabolic process to 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose into other compounds, including 2-oxoglutarate." [GOC:go_curators] synonym: "L-arabinose breakdown to 2-oxoglutarate" EXACT [] synonym: "L-arabinose catabolic process to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolic process to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose catabolism to 2-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-ketoglutarate" EXACT [] synonym: "L-arabinose catabolism to alpha-oxoglutarate" EXACT [] synonym: "L-arabinose degradation to 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0019572 ! L-arabinose catabolic process [Term] id: GO:0019571 name: D-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose, the D-enantiomer of arabino-pentose." [CHEBI:17108, GOC:go_curators, GOC:jsg, GOC:mah] synonym: "D-arabinose breakdown" EXACT [] synonym: "D-arabinose catabolism" EXACT [] synonym: "D-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046372 ! D-arabinose metabolic process [Term] id: GO:0019572 name: L-arabinose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabinose, the L-enantiomer of arabino-pentose." [CHEBI:30849, GOC:go_curators, GOC:jsg, GOC:mah] synonym: "L-arabinose breakdown" EXACT [] synonym: "L-arabinose catabolism" EXACT [] synonym: "L-arabinose degradation" EXACT [] is_a: GO:0019568 ! arabinose catabolic process is_a: GO:0046373 ! L-arabinose metabolic process [Term] id: GO:0019573 name: D-arabinose catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-arabinose to form xylulose 5-phosphate. D-arabinose is converted into D-ribulose, which is phosphorylated to ribulose-5-phosphate, which is isomerized to give D-xylulose-5-phosphate." [GOC:go_curators] synonym: "D-arabinose breakdown to xylulose 5-phosphate" EXACT [] synonym: "D-arabinose degradation to xylulose 5-phosphate" EXACT [] xref: MetaCyc:DARABCAT-PWY is_a: GO:0019571 ! D-arabinose catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019574 name: sucrose catabolic process via 3'-ketosucrose namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds via the conversion of sucrose to 3'-ketosucrose. 3'-ketosucrose is hydrolyzed to 3-ketoglucose and fructose, and the 3-ketoglucose is then be converted to glucose." [GOC:bf, GOC:dgf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose breakdown, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose catabolic process to D-glucose" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose catabolic process, using glucoside 3-dehydrogenase" EXACT [GOC:bf, MetaCyc:SUCROSEUTIL2-PWY] synonym: "sucrose catabolism, using glucoside 3-dehydrogenase" EXACT [] synonym: "sucrose degradation, using glucoside 3-dehydrogenase" EXACT [] xref: MetaCyc:SUCROSEUTIL2-PWY is_a: GO:0005987 ! sucrose catabolic process is_a: GO:0006006 ! glucose metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019575 name: obsolete sucrose catabolic process, using beta-fructofuranosidase namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of sucrose, catalyzed by the enzyme beta-fructofuranosidase (EC:3.2.1.26)." [GOC:jl] comment: This term was made obsolete because beta-fructofuranosidase (also known as invertase) catalyzes the first step in multiple routes of sucrose catabolism. synonym: "sucrose breakdown, using beta-fructofuranosidase" EXACT [] synonym: "sucrose catabolic process, using beta-fructofuranosidase" EXACT [] synonym: "sucrose catabolism, using beta-fructofuranosidase" EXACT [] synonym: "sucrose degradation, using beta-fructofuranosidase" EXACT [] xref: MetaCyc:SUCUTIL-PWY is_obsolete: true consider: GO:0004564 consider: GO:0036008 [Term] id: GO:0019576 name: aerobic fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose that occurs in the presence of oxygen." [GOC:ai] synonym: "aerobic fructose breakdown" EXACT [] synonym: "aerobic fructose catabolism" EXACT [] synonym: "aerobic fructose degradation" EXACT [] is_a: GO:0006001 ! fructose catabolic process [Term] id: GO:0019577 name: aldaric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0019578 name: aldaric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid anabolism" EXACT [] synonym: "aldaric acid biosynthesis" EXACT [] synonym: "aldaric acid formation" EXACT [] synonym: "aldaric acid synthesis" EXACT [] is_a: GO:0016051 ! carbohydrate biosynthetic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process [Term] id: GO:0019579 name: aldaric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldaric acid, any dicarboxylic acid formed by oxidation of by the terminal groups of an aldose to carboxyl group." [ISBN:0198506732] synonym: "aldaric acid breakdown" EXACT [] synonym: "aldaric acid catabolism" EXACT [] synonym: "aldaric acid degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019577 ! aldaric acid metabolic process is_a: GO:0043649 ! dicarboxylic acid catabolic process [Term] id: GO:0019580 name: galactarate metabolic process namespace: biological_process alt_id: GO:0046393 def: "The chemical reactions and pathways involving galactarate, an anion of galactaric acid, the meso-aldaric acid derived from both D- and L-galactose." [GOC:pr, ISBN:0198506732] synonym: "D-galactarate metabolic process" RELATED [] synonym: "D-galactarate metabolism" RELATED [] synonym: "galactarate metabolism" EXACT [] synonym: "mucic acid metabolic process" EXACT [] synonym: "mucic acid metabolism" EXACT [] is_a: GO:0019577 ! aldaric acid metabolic process [Term] id: GO:0019583 name: galactonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactonate, the anion of galactonic acid, an organic acid derived from the sugar galactose." [GOC:ai] synonym: "galactonate metabolism" EXACT [] is_a: GO:0019520 ! aldonic acid metabolic process [Term] id: GO:0019584 name: galactonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactonate, the anion of galactonic acid." [GOC:ai] synonym: "galactonate breakdown" EXACT [] synonym: "galactonate catabolism" EXACT [] synonym: "galactonate degradation" EXACT [] xref: MetaCyc:GALACTCAT-PWY is_a: GO:0019583 ! galactonate metabolic process is_a: GO:0046176 ! aldonic acid catabolic process [Term] id: GO:0019585 name: glucuronate metabolic process namespace: biological_process alt_id: GO:0019699 def: "The chemical reactions and pathways involving glucuronate, any salt or ester of glucuronic acid, the uronic acid formally derived from glucose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [GOC:go_curators, ISBN:0198506732] synonym: "glucuronate metabolism" EXACT [] xref: Wikipedia:Glucuronic_acid is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019586 name: galacturonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonate, the anion of galacturonic acid, the uronic acid formally derived from galactose by oxidation of the hydroxymethylene group at C-6 to a carboxyl group." [ISBN:0198506732] synonym: "galacturonate metabolism" EXACT [] is_a: GO:0006063 ! uronic acid metabolic process [Term] id: GO:0019588 name: anaerobic glycerol catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol, yielding energy in the form of ATP." [GOC:mah] synonym: "glycerol fermentation" EXACT [] is_a: GO:0019563 ! glycerol catabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019589 name: anaerobic glycerol catabolic process to propane-1,3-diol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycerol into propane-1,3-diol and water." [GOC:jl, MetaCyc:GOLPDLCAT-PWY] synonym: "glycerol fermentation to 1,3-propanediol" EXACT [] synonym: "glycerol fermentation to propane-1,3-diol" EXACT [] xref: MetaCyc:GOLPDLCAT-PWY is_a: GO:0019588 ! anaerobic glycerol catabolic process is_a: GO:0051143 ! propanediol metabolic process [Term] id: GO:0019590 name: L-arabitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-arabitol to form xylulose 5-phosphate. L-arabitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-arabitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-arabitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051158 ! L-arabitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019592 name: mannitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol breakdown" EXACT [] synonym: "mannitol catabolism" EXACT [] synonym: "mannitol degradation" EXACT [] xref: MetaCyc:MANNIDEG-PWY xref: MetaCyc:PWY-3861 is_a: GO:0019407 ! hexitol catabolic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019593 name: mannitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol anabolism" EXACT [] synonym: "mannitol biosynthesis" EXACT [] synonym: "mannitol formation" EXACT [] synonym: "mannitol synthesis" EXACT [] xref: MetaCyc:PWY-3881 is_a: GO:0019406 ! hexitol biosynthetic process is_a: GO:0019594 ! mannitol metabolic process [Term] id: GO:0019594 name: mannitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group." [ISBN:0198506732] synonym: "mannitol metabolism" EXACT [] is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0019595 name: non-phosphorylated glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of non-phosphorylated forms of glucose." [GOC:ai] synonym: "non-phosphorylated glucose breakdown" EXACT [] synonym: "non-phosphorylated glucose catabolism" EXACT [] synonym: "non-phosphorylated glucose degradation" EXACT [] xref: MetaCyc:NPGLUCAT-PWY is_a: GO:0006007 ! glucose catabolic process is_a: GO:0046430 ! non-phosphorylated glucose metabolic process [Term] id: GO:0019596 name: mandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mandelate, the anion of mandelic acid. Mandelic acid (alpha-hydroxybenzeneacetic acid) is an 8-carbon alpha-hydroxy acid (AHA) that is used in organic chemistry and as a urinary antiseptic." [GOC:go_curators] synonym: "mandelate breakdown" EXACT [] synonym: "mandelate catabolism" EXACT [] synonym: "mandelate degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0018924 ! mandelate metabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019597 name: (R)-mandelate catabolic process to benzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including benzoate." [GOC:go_curators] synonym: "(R)-mandelate breakdown to benzoate" EXACT [] synonym: "(R)-mandelate degradation to benzoate" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018874 ! benzoate metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0019596 ! mandelate catabolic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0019598 name: (R)-mandelate catabolic process to catechol namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-mandelate into other compounds, including catechol." [GOC:go_curators] synonym: "(R)-mandelate breakdown to catechol" EXACT [] synonym: "(R)-mandelate degradation to catechol" EXACT [] is_a: GO:0009713 ! catechol-containing compound biosynthetic process is_a: GO:0019596 ! mandelate catabolic process [Term] id: GO:0019599 name: (R)-4-hydroxymandelate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of (R)-4-hydroxymandelate, the anion of (R)-4-hydroxymandelic acid." [GOC:ai] synonym: "(R)-4-hydroxymandelate breakdown" EXACT [] synonym: "(R)-4-hydroxymandelate catabolism" EXACT [] synonym: "(R)-4-hydroxymandelate degradation" EXACT [] xref: MetaCyc:4-HYDROXYMANDELATE-DEGRADATION-PWY is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0046431 ! (R)-4-hydroxymandelate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019600 name: toluene oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in toluene." [GOC:mah] is_a: GO:0018970 ! toluene metabolic process is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0019601 name: toluene oxidation via 2-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 2-hydroxytoluene (o-cresol)." [MetaCyc:TOLUENE-DEG-2-OH-PWY] xref: MetaCyc:TOLUENE-DEG-2-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019602 name: toluene oxidation via 3-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form 3-hydroxytoluene (m-cresol)." [MetaCyc:TOLUENE-DEG-3-OH-PWY] xref: MetaCyc:TOLUENE-DEG-3-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019603 name: toluene oxidation via 4-hydroxytoluene namespace: biological_process def: "The degradation of toluene to form p-hydroxybenzoate; the first step in the pathway is the oxidation of toluene to form 4-hydroxytoluene (4-cresol)." [MetaCyc:TOLUENE-DEG-4-OH-PWY] xref: MetaCyc:TOLUENE-DEG-4-OH-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019604 name: toluene oxidation to catechol namespace: biological_process def: "The formation from toluene of catechol, dihydroxybenzene, by successive oxidations followed by loss of carbon dioxide (CO2)." [MetaCyc:TOLUENE-DEG-CATECHOL-PWY] xref: MetaCyc:TOLUENE-DEG-CATECHOL-PWY xref: UM-BBD_pathwayID:tol is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019605 name: butyrate metabolic process namespace: biological_process alt_id: GO:0043437 def: "The chemical reactions and pathways involving any butyrate, the anions of butyric acid (butanoic acid), a saturated, unbranched aliphatic acid." [ISBN:0198506732] synonym: "butanoic acid metabolic process" EXACT [] synonym: "butanoic acid metabolism" EXACT [] synonym: "butyrate metabolism" EXACT [] synonym: "butyric acid metabolic process" EXACT [] synonym: "butyric acid metabolism" EXACT [] is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019606 name: 2-oxobutyrate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-oxobutyrate, the anion of the organic acid 2-oxobutyric acid, which contains a ketone group on carbon 2." [ISBN:0198506732] synonym: "2-oxobutyrate breakdown" EXACT [] synonym: "2-oxobutyrate catabolism" EXACT [] synonym: "2-oxobutyrate degradation" EXACT [] synonym: "alpha-ketobutyrate catabolic process" EXACT [] synonym: "alpha-ketobutyrate catabolism" EXACT [] xref: MetaCyc:2OXOBUTYRATECAT-PWY is_a: GO:0019626 ! short-chain fatty acid catabolic process is_a: GO:0046361 ! 2-oxobutyrate metabolic process [Term] id: GO:0019607 name: phenylethylamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylethylamine, an amine with pharmacological properties similar to those of amphetamine, occurs naturally as a neurotransmitter in the brain, and is present in chocolate and oil of bitter almonds." [GOC:jl, ISBN:0395825172] synonym: "phenylethylamine breakdown" EXACT [] synonym: "phenylethylamine catabolism" EXACT [] synonym: "phenylethylamine degradation" EXACT [] xref: MetaCyc:2PHENDEG-PWY is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042443 ! phenylethylamine metabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0019608 name: nicotine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine." [GOC:sm, ISBN:0198547684] synonym: "nicotine breakdown" EXACT [] synonym: "nicotine catabolism" EXACT [] synonym: "nicotine degradation" EXACT [] xref: MetaCyc:P181-PWY xref: UM-BBD_pathwayID:nic is_a: GO:0018933 ! nicotine metabolic process is_a: GO:0042737 ! drug catabolic process [Term] id: GO:0019609 name: 3-hydroxyphenylacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] synonym: "3-hydroxyphenylacetate metabolism" EXACT [] synonym: "3HPA metabolic process" EXACT [] synonym: "3HPA metabolism" EXACT [] is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019610 name: 3-hydroxyphenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-hydroxyphenylacetate, 1,3-benzenediol monoacetate, also known as resorcinol monoacetate." [http://chemfinder.cambridgesoft.com/] synonym: "3-hydroxyphenylacetate breakdown" EXACT [] synonym: "3-hydroxyphenylacetate catabolism" EXACT [] synonym: "3-hydroxyphenylacetate degradation" EXACT [] xref: MetaCyc:3-HYDROXYPHENYLACETATE-DEGRADATION-PWY is_a: GO:0019336 ! phenol-containing compound catabolic process is_a: GO:0019609 ! 3-hydroxyphenylacetate metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019611 name: 4-toluenecarboxylate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] synonym: "4-toluenecarboxylate metabolism" EXACT [] synonym: "p-toluate metabolic process" EXACT [] synonym: "p-toluate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0019612 name: 4-toluenecarboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 4-toluenecarboxylate, 4-methylbenzenecarboxylate, the anion of carboxylic acid attached to a methylbenzene molecule." [GOC:ai] synonym: "4-toluenecarboxylate breakdown" EXACT [] synonym: "4-toluenecarboxylate catabolism" EXACT [] synonym: "4-toluenecarboxylate degradation" EXACT [] synonym: "p-toluate catabolic process" EXACT [] synonym: "p-toluate catabolism" EXACT [] xref: MetaCyc:4TOLCARBDEG-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0019611 ! 4-toluenecarboxylate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019614 name: catechol-containing compound catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol-containing compounds. Catechol is a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] synonym: "catechol breakdown" RELATED [] synonym: "catechol catabolic process" RELATED [] synonym: "catechol catabolism" RELATED [] synonym: "catechol degradation" RELATED [] is_a: GO:0009712 ! catechol-containing compound metabolic process is_a: GO:0019336 ! phenol-containing compound catabolic process [Term] id: GO:0019615 name: catechol catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the ortho-cleavage pathway, in which the catechol aromatic ring is broken between the two carbon atoms bearing hydroxyl groups." [GOC:jl, http://www.ence.umd.edu/] synonym: "catechol breakdown, ortho-cleavage" EXACT [] synonym: "catechol degradation, ortho-cleavage" EXACT [] xref: MetaCyc:CATECHOL-ORTHO-CLEAVAGE-PWY is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042952 ! beta-ketoadipate pathway [Term] id: GO:0019616 name: catechol catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of catechol via the meta-cleavage pathway, in which the catechol aromatic ring is broken between a hydroxylated carbon atom and an adjacent unsubstituted carbon atom." [GOC:jl, http://www.ence.umd.edu/] synonym: "catechol breakdown, meta-cleavage" EXACT [] synonym: "catechol degradation, meta-cleavage" EXACT [] xref: MetaCyc:P183-PWY is_a: GO:0019614 ! catechol-containing compound catabolic process [Term] id: GO:0019617 name: protocatechuate catabolic process, meta-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield oxaloacetate and pyruvate." [MetaCyc:P184-PWY] synonym: "3,4-dihydroxybenzoate catabolic process, meta-cleavage" RELATED [CHEBI:36241] synonym: "protocatechuate breakdown, meta-cleavage" EXACT [] synonym: "protocatechuate catabolic process to oxaloacetate and pyruvate" EXACT [] synonym: "protocatechuate degradation, meta-cleavage" EXACT [] xref: MetaCyc:P184-PWY is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0006107 ! oxaloacetate metabolic process is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process [Term] id: GO:0019618 name: protocatechuate catabolic process, ortho-cleavage namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of protocatechuate, the anion of 3,4-dihydroxybenzoic acid, to yield beta-ketoadipate." [MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY] synonym: "3,4-dihydroxybenzoate catabolic process, ortho-cleavage" EXACT [CHEBI:36241] synonym: "protocatechuate breakdown, ortho-cleavage" EXACT [] synonym: "protocatechuate catabolic process to beta-ketoadipate" EXACT [] synonym: "protocatechuate degradation, ortho-cleavage" EXACT [] xref: MetaCyc:PROTOCATECHUATE-ORTHO-CLEAVAGE-PWY is_a: GO:0019619 ! 3,4-dihydroxybenzoate catabolic process is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0019619 name: 3,4-dihydroxybenzoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3,4-dihydroxybenzoate." [GOC:ai] synonym: "protocatechuate breakdown" EXACT [] synonym: "protocatechuate catabolic process" EXACT [CHEBI:36241] synonym: "protocatechuate catabolism" EXACT [] synonym: "protocatechuate degradation" EXACT [] is_a: GO:0019614 ! catechol-containing compound catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046278 ! 3,4-dihydroxybenzoate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0019620 name: aerobic benzoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving benzoate, the anion of benzoic acid (benzenecarboxylic acid) that occur in the presence of oxygen." [GOC:ai] synonym: "aerobic benzoate metabolism" EXACT [] is_a: GO:0018874 ! benzoate metabolic process [Term] id: GO:0019621 name: creatinine catabolic process to formate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine into other compounds, including formate." [GOC:go_curators] synonym: "creatinine breakdown to formate" EXACT [] synonym: "creatinine degradation to formate" EXACT [] xref: MetaCyc:CRNFORCAT-PWY is_a: GO:0006602 ! creatinine catabolic process is_a: GO:0015942 ! formate metabolic process [Term] id: GO:0019622 name: 3-(3-hydroxy)phenylpropionate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 3-(3-hydroxy)phenylpropionate, a hydroxylated derivative of phenylpropionate." [GOC:ai] synonym: "3-(3-hydroxy)phenylpropionate breakdown" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate catabolism" EXACT [] synonym: "3-(3-hydroxy)phenylpropionate degradation" EXACT [] xref: MetaCyc:HCAMHPDEG-PWY is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:0046435 ! 3-(3-hydroxy)phenylpropionate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019623 name: atrazine catabolic process to urea namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into urea." [GOC:jl] synonym: "atrazine breakdown to urea" EXACT [] synonym: "atrazine degradation to urea" EXACT [] is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0019627 ! urea metabolic process [Term] id: GO:0019624 name: atrazine catabolic process to isopropylamine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into isopropylamine." [GOC:jl] synonym: "atrazine breakdown to isopropylamine" EXACT [] synonym: "atrazine degradation to isopropylamine" EXACT [] is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0019625 name: atrazine catabolic process to cyanuric acid namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of atrazine, a triazine ring-containing herbicide, into cyanuric acid." [GOC:jl] synonym: "atrazine breakdown to cyanuric acid" EXACT [] synonym: "atrazine degradation to cyanuric acid" EXACT [] xref: MetaCyc:P141-PWY is_a: GO:0019381 ! atrazine catabolic process is_a: GO:0042199 ! cyanuric acid metabolic process [Term] id: GO:0019626 name: short-chain fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fatty acids with a chain length of less than C6." [CHEBI:26666, ISBN:0198506732] synonym: "short-chain fatty acid breakdown" EXACT [] synonym: "short-chain fatty acid catabolism" EXACT [] synonym: "short-chain fatty acid degradation" EXACT [] xref: MetaCyc:ACETOACETATE-DEG-PWY is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0046459 ! short-chain fatty acid metabolic process [Term] id: GO:0019627 name: urea metabolic process namespace: biological_process def: "The chemical reactions and pathways involving urea, the water soluble compound O=C-(NH2)2." [ISBN:0198506732] synonym: "urea metabolism" EXACT [] is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0044281 ! small molecule metabolic process is_a: GO:0071941 ! nitrogen cycle metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019628 name: urate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of urate, the anion of uric acid, 2,6,8-trioxypurine." [ISBN:0198506732] synonym: "urate breakdown" EXACT [] synonym: "urate catabolism" EXACT [] synonym: "urate degradation" EXACT [] synonym: "uric acid catabolic process" EXACT [] xref: MetaCyc:P165-PWY is_a: GO:0044282 ! small molecule catabolic process is_a: GO:0046415 ! urate metabolic process is_a: GO:0072523 ! purine-containing compound catabolic process [Term] id: GO:0019629 name: propionate catabolic process, 2-methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of propionate that occurs in the 2-methylcitrate cycle." [GOC:go_curators] synonym: "propionate breakdown, 2-methylcitrate cycle" EXACT [] synonym: "propionate degradation, 2-methylcitrate cycle" EXACT [] is_a: GO:0019543 ! propionate catabolic process [Term] id: GO:0019630 name: quinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving quinate, the anion of quinic acid. The acid occurs commonly in plants, either free or as esters, and is used as a medicine." [GOC:jl, ISBN:0198506732] synonym: "quinate metabolism" EXACT [] synonym: "quinic acid metabolic process" EXACT [] synonym: "quinic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0019631 name: quinate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of quinate, the anion of quinic acid." [GOC:jl] synonym: "quinate breakdown" EXACT [] synonym: "quinate catabolism" EXACT [] synonym: "quinate degradation" EXACT [] synonym: "quinic acid catabolic process" EXACT [] synonym: "quinic acid catabolism" EXACT [] xref: MetaCyc:QUINATEDEG-PWY is_a: GO:0019630 ! quinate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019632 name: shikimate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids." [CHEBI:36208, GOC:sm, ISBN:0198547684] synonym: "shikimate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1901615 ! organic hydroxy compound metabolic process [Term] id: GO:0019633 name: shikimate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid." [CHEBI:36208, GOC:go_curators] synonym: "shikimate breakdown" EXACT [] synonym: "shikimate catabolism" EXACT [] synonym: "shikimate degradation" EXACT [] xref: MetaCyc:SHIKIMATEDEG-PWY is_a: GO:0019632 ! shikimate metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0019634 name: organic phosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphonates, any organic compounds containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Metabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js, ISBN:0721662544] synonym: "organophosphonate metabolic process" RELATED [] synonym: "phosphonate metabolism" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0019635 name: 2-aminoethylphosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 2-aminoethylphosphonate, also known as ciliatine." [GOC:ai] synonym: "2-aminoethylphosphonate breakdown" EXACT [] synonym: "2-aminoethylphosphonate catabolism" EXACT [] synonym: "2-aminoethylphosphonate degradation" EXACT [] synonym: "2-phosphonoethylamine catabolic process" EXACT [] synonym: "2-phosphonoethylamine catabolism" EXACT [] synonym: "ciliatine catabolic process" EXACT [] synonym: "ciliatine catabolism" EXACT [] xref: MetaCyc:PHOSPHONOTASE-PWY is_a: GO:0046433 ! 2-aminoethylphosphonate metabolic process is_a: GO:1901161 ! primary amino compound catabolic process [Term] id: GO:0019636 name: phosphonoacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphonoacetate, C2H4PO5, a substance composed of an acetate and a phosphonic acid residue." [MetaCyc:P483-PWY] synonym: "phosphonoacetate metabolism" EXACT [] xref: MetaCyc:P483-PWY is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0019637 name: organophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organophosphates, any phosphate-containing organic compound." [ISBN:0198506732] synonym: "organophosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0019638 name: 6-hydroxycineole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] synonym: "6-endo-hydroxycineole metabolic process" EXACT [] synonym: "6-endo-hydroxycineole metabolism" EXACT [] synonym: "6-hydroxycineole metabolism" EXACT [] synonym: "hydroxycineol metabolic process" EXACT [] synonym: "hydroxycineol metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0097176 ! epoxide metabolic process [Term] id: GO:0019639 name: 6-hydroxycineole catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 6-hydroxycineole (6-hydroxy-1,8-epoxy-p-menthane), a hydrocarbon with the formula C10H18O2." [GOC:ai] synonym: "6-endo-hydroxycineole catabolic process" EXACT [] synonym: "6-endo-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole breakdown" EXACT [] synonym: "6-hydroxycineole catabolism" EXACT [] synonym: "6-hydroxycineole degradation" EXACT [] synonym: "hydroxycineol catabolic process" EXACT [] synonym: "hydroxycineol catabolism" EXACT [] xref: MetaCyc:6-HYDROXYCINEOLE-DEGRADATION-PWY is_a: GO:0016100 ! monoterpenoid catabolic process is_a: GO:0019638 ! 6-hydroxycineole metabolic process is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901502 ! ether catabolic process [Term] id: GO:0019640 name: glucuronate catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate into other compounds, including xylulose 5-phosphate." [GOC:go_curators] synonym: "glucuronate breakdown to xylulose 5-phosphate" EXACT [] synonym: "glucuronate degradation to xylulose 5-phosphate" EXACT [] is_a: GO:0006064 ! glucuronate catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019643 name: reductive tricarboxylic acid cycle namespace: biological_process alt_id: GO:0019644 def: "A pathway leading to the fixation of two molecules of CO2 and the production of one molecule of acetyl-CoA; essentially the oxidative TCA cycle running in reverse. Acetyl-CoA is reductively carboxylated to pyruvate, from which all other central metabolites can be formed. Most of the enzymes of reductive and oxidative TCA cycle are shared, with the exception of three key enzymes that allow the cycle to run in reverse: ATP citrate lyase, 2-oxoglutarate:ferredoxin oxidoreductase, and fumarate reductase. 2-oxoglutarate:ferredoxin oxidoreductase catalyzes the carboxylation of succinyl-CoA to 2-oxoglutarate, ATP citrate lyase the ATP-dependent cleavage of citrate to acetyl-CoA and oxaloacetate, and fumarate reductase the reduction of fumarate forming succinate." [GOC:jl, PMID:15838028] synonym: "reductive carboxylate cycle" EXACT [] synonym: "reductive carboxylic acid cycle" EXACT [] synonym: "reductive citric acid pathway" EXACT [] synonym: "reductive Kreb's cycle" EXACT [] synonym: "reductive TCA cycle" EXACT [] xref: MetaCyc:P23-PWY xref: MetaCyc:REDCITCYC is_a: GO:0006099 ! tricarboxylic acid cycle is_a: GO:0015977 ! carbon fixation [Term] id: GO:0019645 name: anaerobic electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0009061 ! anaerobic respiration [Term] id: GO:0019646 name: aerobic electron transport chain namespace: biological_process alt_id: GO:0006136 alt_id: GO:0006137 alt_id: GO:0006138 def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient." [GOC:ai, GOC:mtg_electron_transport] synonym: "NADH-O2 electron transport" NARROW [] synonym: "succinate-O2 electron transport" NARROW [] synonym: "ubiquinone-8-O2 electron transport" NARROW [] is_a: GO:0009060 ! aerobic respiration is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0019647 name: formaldehyde assimilation via ribulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the ribulose monophosphate cycle. Methanotrophic bacteria produce formaldehyde from the oxidation of methane and methanol, and then assimilate it via the ribulose monophosphate cycle to form intermediates of the central metabolic routes that are subsequently used for biosynthesis of cell material. Three molecules of formaldehyde are assimilated, forming a three-carbon intermediate of central metabolism; in this pathway, all cellular carbon is assimilated at the oxidation level of formaldehyde." [MetaCyc:PWY-1861] synonym: "formaldehyde assimilation via RuMP cycle" EXACT [] synonym: "ribulose monophosphate cycle" BROAD [] xref: MetaCyc:PWY-1861 is_a: GO:0019649 ! formaldehyde assimilation [Term] id: GO:0019648 name: formaldehyde assimilation via xylulose monophosphate cycle namespace: biological_process def: "The pathway in which formaldehyde is used as a carbon source in the xylulose monophosphate cycle. Methylotrophic yeasts, but not bacteria, utilize the xylulose monophosphate cycle to fix formaldehyde and convert it into metabolically useful organic compounds." [MetaCyc:P185-PWY] synonym: "formaldehyde assimilation via xylulose-5-phosphate cycle" EXACT [] synonym: "formaldehyde fixation cycle" EXACT [] xref: MetaCyc:P185-PWY is_a: GO:0019649 ! formaldehyde assimilation is_a: GO:0051167 ! xylulose 5-phosphate metabolic process [Term] id: GO:0019649 name: formaldehyde assimilation namespace: biological_process def: "The pathways in which formaldehyde is processed and used as a carbon source for the cell." [GOC:ai] is_a: GO:0046292 ! formaldehyde metabolic process [Term] id: GO:0019650 name: glycolytic fermentation to butanediol namespace: biological_process alt_id: GO:0030646 def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into butanediol; effected by some members of the Enterobacteriaceae, e.g. Enterobacter, Erwinia, Klebsiella, and Serratia." [GOC:dph, GOC:nr, ISBN:0198506732] synonym: "butanediol fermentation" EXACT [] synonym: "glucose catabolic process to butanediol" EXACT [GOC:dph] synonym: "glucose fermentation to butanediol" EXACT [] xref: MetaCyc:P125-PWY xref: Wikipedia:Butanediol_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019651 name: citrate catabolic process to diacetyl namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of citrate to diacetyl, yielding energy in the form of ATP." [MetaCyc:P126-PWY] synonym: "citrate fermentation to diacetyl" EXACT [] synonym: "diacetyl fermentation" EXACT [] is_a: GO:0006101 ! citrate metabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0019662 ! non-glycolytic fermentation is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process [Term] id: GO:0019652 name: lactate fermentation to propionate and acetate namespace: biological_process def: "The anaerobic enzymatic conversion of lactate to propionate, concomitant with the oxidation of lactate to acetate and CO2 and yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl, MetaCyc:PROPFERM-PWY] synonym: "acrylate pathway" EXACT [] synonym: "nonrandomizing pathway" EXACT [] synonym: "propionate fermentation" EXACT [] xref: MetaCyc:PROPFERM-PWY is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019653 name: anaerobic purine nucleobase catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of purine nucleobases, yielding energy in the form of ATP." [CHEBI:26386, GOC:mah] synonym: "anaerobic purine base catabolic process" EXACT [GOC:go_curators] synonym: "anaerobic purine base catabolism" EXACT [GOC:curators] synonym: "anaerobic purine catabolic process" RELATED [GOC:curators] synonym: "purine base fermentation" EXACT [GOC:curators] synonym: "purine fermentation" RELATED [GOC:curators] xref: MetaCyc:P164-PWY xref: MetaCyc:PWY-5044 xref: MetaCyc:PWY-5497 is_a: GO:0006145 ! purine nucleobase catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0019654 name: acetate fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate, yielding energy in the form of ATP." [CHEBI:30089, GOC:jl, MetaCyc:P142-PWY] xref: MetaCyc:P142-PWY is_a: GO:0006083 ! acetate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019655 name: glycolytic fermentation to ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose; it is converted into ethanol and carbon dioxide (CO2), producing two molecules of ATP for each molecule of glucose." [GOC:dph, GOC:nr, ISBN:0716720094] synonym: "alcoholic fermentation" RELATED [ISBN:124925502] synonym: "ethanol fermentation" EXACT [] synonym: "glucose catabolic process to ethanol" EXACT [GOC:dph] synonym: "glucose fermentation to ethanol" EXACT [] xref: Wikipedia:Ethanol_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019656 name: glucose catabolic process to D-lactate and ethanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the enzymatic breakdown of D-glucose to D-lactate and ethanol, yielding energy in the form of adenosine triphosphate (ATP) at the rate of one ATP per glucose molecule." [GOC:jl, MetaCyc:P122-PWY] synonym: "glucose fermentation to D-lactate and ethanol" EXACT [] synonym: "heterofermentation" EXACT [] synonym: "heterofermentative lactate fermentation" EXACT [] synonym: "heterofermentative pathway" EXACT [] synonym: "heterolactate fermentation" EXACT [] synonym: "heterolactic fermentation" EXACT [] xref: MetaCyc:P122-PWY is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019662 ! non-glycolytic fermentation is_a: GO:1902707 ! hexose catabolic process to ethanol [Term] id: GO:0019657 name: glycolytic fermentation to propionate namespace: biological_process def: "Glycolytic fermentation resulting in the catabolism of glucose to propionate, yielding energy in the form of ATP; an alternative to the acrylate pathway to produce propionate." [GOC:dph, GOC:nr, MetaCyc:P108-PWY] synonym: "succinate-propionate fermentation" EXACT [] xref: MetaCyc:P108-PWY is_a: GO:0006105 ! succinate metabolic process is_a: GO:0019541 ! propionate metabolic process is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0042867 ! pyruvate catabolic process [Term] id: GO:0019658 name: glucose fermentation to lactate and acetate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose to lactate and acetate, yielding energy in the form of ATP." [MetaCyc:P124-PWY] synonym: "bifidum pathway" EXACT [] synonym: "glucose catabolic process to lactate and acetate" BROAD [] xref: MetaCyc:P124-PWY is_a: GO:0006007 ! glucose catabolic process is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019659 name: glucose catabolic process to lactate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, and possibly ethanol, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] synonym: "glucose fermentation to lactate" EXACT [] synonym: "lactate fermentation" EXACT [] xref: Wikipedia:Lactic_acid_fermentation is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006089 ! lactate metabolic process is_a: GO:0006113 ! fermentation [Term] id: GO:0019660 name: glycolytic fermentation namespace: biological_process def: "Fermentation that includes the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:curators] xref: MetaCyc:Pyruvate-Degredation is_a: GO:0006113 ! fermentation is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0019661 name: glucose catabolic process to lactate via pyruvate namespace: biological_process def: "The anaerobic enzymatic chemical reactions and pathways resulting in the breakdown of glucose to lactate, via canonical glycolysis, yielding energy in the form of adenosine triphosphate (ATP)." [GOC:jl] synonym: "glucose fermentation to lactate via pyruvate" EXACT [] synonym: "homofermentation" EXACT [] synonym: "homofermentative lactate fermentation" EXACT [] synonym: "homofermentative pathway" EXACT [] synonym: "homolactate fermentation" EXACT [] synonym: "homolactic fermentation" EXACT [ISBN:124925502] xref: MetaCyc:ANAEROFRUCAT-PWY is_a: GO:0006734 ! NADH metabolic process is_a: GO:0019659 ! glucose catabolic process to lactate is_a: GO:0019660 ! glycolytic fermentation is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0019662 name: non-glycolytic fermentation namespace: biological_process def: "Fermentation that does not include the anaerobic conversion of glucose to pyruvate via the glycolytic pathway." [GOC:jl, MetaCyc:Fermentation] is_a: GO:0006113 ! fermentation [Term] id: GO:0019664 name: mixed acid fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose into ethanol, lactate, formate, succinate, and acetate, yielding energy in the form of ATP." [MetaCyc:FERMENTATION-PWY, PMID:124925502] synonym: "glucose catabolic process to mixed acids" BROAD [] synonym: "glucose fermentation to mixed acids" EXACT [] xref: Wikipedia:Mixed_acid_fermentation is_a: GO:0019660 ! glycolytic fermentation [Term] id: GO:0019665 name: anaerobic amino acid catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids, yielding energy in the form of ATP." [GOC:curators, GOC:jl, MetaCyc:Fermentation] synonym: "amino acid fermentation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0019666 ! nitrogenous compound fermentation [Term] id: GO:0019666 name: nitrogenous compound fermentation namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of a nitrogen-containing compound, yielding energy in the form of ATP." [GOC:mah] synonym: "nitrogenous compound catabolic process" BROAD [] is_a: GO:0006113 ! fermentation is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0019667 name: anaerobic L-alanine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of L-alanine, yielding energy in the form of ATP." [GOC:jl] synonym: "L-alanine fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019668 name: anaerobic catabolism of pairs of amino acids namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of amino acids; in these reactions, one amino acid is oxidised (acts as an electron donor) and a different amino acid is reduced (acts as an electron acceptor); oxidation of the electron-donating amino acid yields energy in the form of ATP." [GOC:mah, PMID:13140081] synonym: "cofermentation of pairs of amino acids" EXACT [] synonym: "Stickland reaction" NARROW [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019669 name: anaerobic glycine catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glycine, yielding energy in the form of ATP." [GOC:jl] synonym: "glycine fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019670 name: anaerobic glutamate catabolic process namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate, yielding energy in the form of ATP." [GOC:jl] synonym: "glutamate fermentation" EXACT [] is_a: GO:0019665 ! anaerobic amino acid catabolic process [Term] id: GO:0019671 name: glutamate catabolic process via mesaconate and citramalate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glutamate via the intermediates mesaconate and S-citramalate, yielding energy in the form of ATP." [MetaCyc:GLUDEG-II-PWY] synonym: "glutamate fermentation via mesaconate and citramalate" EXACT [] xref: MetaCyc:GLUDEG-II-PWY xref: MetaCyc:PWY-5087 xref: MetaCyc:PWY-5088 is_a: GO:0019670 ! anaerobic glutamate catabolic process [Term] id: GO:0019672 name: ethanol-acetate fermentation to butyrate and caproate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of ethanol and acetate to butyrate and caproate, yielding energy in the form of ATP." [MetaCyc:P127-PWY] is_a: GO:0019662 ! non-glycolytic fermentation [Term] id: GO:0019673 name: GDP-mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] synonym: "GDP-mannose metabolism" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0019674 name: NAD metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) metabolic process" EXACT [] synonym: "NAD (oxidized) metabolism" EXACT [] synonym: "NAD metabolism" EXACT [] synonym: "NAD phosphorylation and dephosphorylation" NARROW [] synonym: "nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide metabolism" EXACT [] synonym: "oxidized NAD metabolic process" EXACT [] synonym: "oxidized NAD metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0019675 name: obsolete NAD phosphorylation and dephosphorylation namespace: biological_process def: "OBSOLETE. The addition or removal of a phosphate group from nicotinamide adenine dinucleotide (NAD), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] comment: This term was made obsolete because it represents a process, NAD dephosphorylation, that does not exist. synonym: "NAD phosphorylation and dephosphorylation" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphorylation and dephosphorylation" EXACT [] is_obsolete: true consider: GO:0006739 consider: GO:0019674 [Term] id: GO:0019676 name: ammonia assimilation cycle namespace: biological_process def: "The pathway by which ammonia is processed and incorporated into a cell. In an energy-rich (glucose-containing), nitrogen-poor environment, glutamine synthetase and glutamate synthase form an ammonia assimilatory cycle, in which ammonia is incorporated into L-glutamate to form L-glutamine, which then combines with alpha-ketoglutarate to regenerate L-glutamate. This ATP-dependent cycle is essential for nitrogen-limited growth and for steady-state growth with some sources of nitrogen." [MetaCyc:AMMASSIM-PWY] synonym: "glutamate metabolic process via glutamine and ammonia" EXACT [] synonym: "glutamate metabolism via glutamine and ammonia" EXACT [] xref: MetaCyc:AMMASSIM-PWY xref: MetaCyc:PWY-3282 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0019740 ! nitrogen utilization [Term] id: GO:0019677 name: NAD catabolic process namespace: biological_process alt_id: GO:0006737 def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; catabolism may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] synonym: "NAD (oxidized) catabolic process" EXACT [] synonym: "NAD (oxidized) catabolism" EXACT [] synonym: "NAD (reduced) catabolic process" EXACT [] synonym: "NAD (reduced) catabolism" EXACT [] synonym: "NAD breakdown" EXACT [] synonym: "NAD catabolism" EXACT [] synonym: "NAD degradation" EXACT [] synonym: "NADH catabolic process" EXACT [] synonym: "NADH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "oxidized NAD catabolic process" EXACT [] synonym: "oxidized NAD catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide catabolism" EXACT [] synonym: "reduced NAD catabolic process" EXACT [] synonym: "reduced NAD catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide catabolism" EXACT [] is_a: GO:0019364 ! pyridine nucleotide catabolic process is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0019678 name: propionate metabolic process, methylmalonyl pathway namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylmalonyl pathway." [GOC:go_curators] synonym: "propionate metabolism, methylmalonyl pathway" EXACT [] xref: MetaCyc:PROPIONMET-PWY is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019679 name: propionate metabolic process, methylcitrate cycle namespace: biological_process def: "The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle." [GOC:go_curators] synonym: "propionate metabolism, methylcitrate cycle" EXACT [] xref: MetaCyc:PWY0-42 is_a: GO:0019541 ! propionate metabolic process [Term] id: GO:0019680 name: L-methylmalonyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-methylmalonyl-CoA, the L-enantiomer of 2-carboxypropanoyl-CoA." [GOC:ai, GOC:jsg, GOC:mah] synonym: "L-methylmalonyl-CoA anabolism" EXACT [] synonym: "L-methylmalonyl-CoA biosynthesis" EXACT [] synonym: "L-methylmalonyl-CoA formation" EXACT [] synonym: "L-methylmalonyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY0-43 is_a: GO:0046491 ! L-methylmalonyl-CoA metabolic process is_a: GO:0071616 ! acyl-CoA biosynthetic process [Term] id: GO:0019681 name: acetyl-CoA assimilation pathway namespace: biological_process def: "The pathways by which acetyl-CoA is processed and converted into alpha-ketoglutarate (2-oxoglutarate); methanogenic archaea use these pathways to assimilate acetyl-CoA into the cell." [MetaCyc:P22-PWY] synonym: "acetyl-CoA catabolic process to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolic process to alpha-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to 2-oxoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-ketoglutarate" EXACT [] synonym: "acetyl-CoA catabolism to alpha-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0046356 ! acetyl-CoA catabolic process [Term] id: GO:0019682 name: glyceraldehyde-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [GOC:ai, ISBN:0198506732] synonym: "glyceraldehyde 3-phosphate metabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate metabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019683 name: glyceraldehyde-3-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyceraldehyde-3-phosphate, an important intermediate in glycolysis." [ISBN:0198506732] synonym: "glyceraldehyde 3-phosphate catabolic process" EXACT [] synonym: "glyceraldehyde 3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate breakdown" EXACT [] synonym: "glyceraldehyde-3-phosphate catabolism" EXACT [] synonym: "glyceraldehyde-3-phosphate degradation" EXACT [] is_a: GO:0019682 ! glyceraldehyde-3-phosphate metabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901136 ! carbohydrate derivative catabolic process [Term] id: GO:0019684 name: photosynthesis, light reaction namespace: biological_process def: "The light reactions of photosynthesis, which take place in photosystems II and I. Light energy is harvested and used to power the transfer of electrons among a series of electron donors and acceptors. The final electron acceptor is NADP+, which is reduced to NADPH. NADPH generated from light reactions is used in sugar synthesis in dark reactions. Light reactions also generate a proton motive force across the thylakoid membrane, and the proton gradient is used to synthesize ATP. There are two chemical reactions involved in the light reactions: water oxidation in photosystem II, and NADP reduction in photosystem I." [http://www.arabidopsis.org] synonym: "photolysis" RELATED [] xref: MetaCyc:PWY-101 xref: Wikipedia:Photolysis#Photolysis_in_photosynthesis is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019685 name: photosynthesis, dark reaction namespace: biological_process def: "A complex cycle of enzyme-mediated reactions which catalyzes the reduction of carbon dioxide to sugar. As well as carbon dioxide the cycle requires reducing power in the form of reduced nicotinamide adenine dinucleotide phosphate (NADP) and chemical energy in the form of adenosine triphosphate (ATP). The reduced NADP (NADPH) and ATP are produced by the 'light' reactions." [ISBN:0582015952] is_a: GO:0016051 ! carbohydrate biosynthetic process relationship: part_of GO:0015979 ! photosynthesis [Term] id: GO:0019686 name: purine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine nucleoside is synthesized from another purine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0015949 ! nucleobase-containing small molecule interconversion is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0019687 name: pyruvate biosynthetic process from acetate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyruvate from other compounds, including acetate." [GOC:go_curators] synonym: "pyruvate anabolism from acetate" EXACT [] synonym: "pyruvate formation from acetate" EXACT [] synonym: "pyruvate synthesis from acetate" EXACT [] is_a: GO:0006083 ! acetate metabolic process is_a: GO:0042866 ! pyruvate biosynthetic process [Term] id: GO:0019688 name: purine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a purine deoxyribonucleoside is synthesized from another purine deoxyribonucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0019686 ! purine nucleoside interconversion is_a: GO:0046122 ! purine deoxyribonucleoside metabolic process [Term] id: GO:0019689 name: pyrimidine nucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine nucleoside is synthesized from another pyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0006213 ! pyrimidine nucleoside metabolic process is_a: GO:0015949 ! nucleobase-containing small molecule interconversion [Term] id: GO:0019690 name: pyrimidine deoxyribonucleoside interconversion namespace: biological_process def: "The chemical reactions and pathways by which a pyrimidine deoxyribonucleoside is synthesized from another deoxyribopyrimidine nucleoside." [GOC:mah, ISBN:0306444747, ISBN:0471394831] is_a: GO:0019689 ! pyrimidine nucleoside interconversion is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0019692 name: deoxyribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose." [ISBN:0198506732] synonym: "deoxyribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019693 name: ribose phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ribose phosphate, any phosphorylated ribose sugar." [GOC:ai] synonym: "ribose phosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0019694 name: alkanesulfonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkanesulfonates, the anion of alkanesulfonic acids, sulfonic acid derivatives containing an aliphatic hydrocarbon group." [GOC:ai] synonym: "alkanesulfonate metabolism" EXACT [] synonym: "alkanesulphonate metabolic process" EXACT [] synonym: "alkanesulphonate metabolism" EXACT [] xref: MetaCyc:ALKANEMONOX-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0006790 ! sulfur compound metabolic process [Term] id: GO:0019695 name: choline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving choline (2-hydroxyethyltrimethylammonium), an amino alcohol that occurs widely in living organisms as a constituent of certain types of phospholipids and in the neurotransmitter acetylcholine." [GOC:jl, ISBN:0192801023] synonym: "choline metabolism" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0071704 ! organic substance metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0019696 name: toluene oxidation via toluene-cis-1,2-dihydrodiol namespace: biological_process def: "The degradation of toluene to form pyruvate and acetaldehyde; the first step in the pathway is the oxidation of toluene to form toluene-cis-1,2-dihydrodiol." [MetaCyc:TOLUENE-DEG-DIOL-PWY] xref: MetaCyc:TOLUENE-DEG-DIOL-PWY is_a: GO:0019600 ! toluene oxidation [Term] id: GO:0019697 name: L-xylitol catabolic process to xylulose 5-phosphate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-xylitol to form xylulose 5-phosphate. L-xylitol is converted into L-xylulose, which is then phosphorylated to L-xylulose-5-phosphate. This is converted to D-xylulose-5-phosphate via the intermediate L-ribulose-5-phosphate." [MetaCyc:LARABITOLUTIL-PWY] synonym: "L-arabitol and xylitol degradation" BROAD [] synonym: "L-xylitol breakdown to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol degradation to xylulose 5-phosphate" EXACT [] synonym: "L-xylitol utilization" RELATED [] xref: MetaCyc:LARABITOLUTIL-PWY is_a: GO:0051160 ! L-xylitol catabolic process is_a: GO:1901159 ! xylulose 5-phosphate biosynthetic process [Term] id: GO:0019698 name: D-galacturonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid." [GOC:ai, GOC:jsg, GOC:mah] synonym: "D-galacturonate breakdown" EXACT [] synonym: "D-galacturonate catabolism" EXACT [] synonym: "D-galacturonate degradation" EXACT [] xref: MetaCyc:GALACTUROCAT-PWY is_a: GO:0046396 ! D-galacturonate metabolic process is_a: GO:0046397 ! galacturonate catabolic process [Term] id: GO:0019700 name: organic phosphonate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] synonym: "organophosphonate catabolic process" RELATED [] synonym: "phosphonate breakdown" EXACT [] synonym: "phosphonate catabolism" EXACT [] synonym: "phosphonate degradation" EXACT [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0019701 name: peptidyl-arginine N5-methylation namespace: biological_process def: "The methylation of peptidyl-arginine on the internal nitrogen-5 (N5) atom (also called delta-nitrogen) to form peptidyl-N5-methyl-L-arginine." [GOC:bf, PMID:9792625, RESID:AA0305] synonym: "peptidyl-arginine delta-N-methylation" EXACT [] xref: RESID:AA0305 is_a: GO:0035246 ! peptidyl-arginine N-methylation [Term] id: GO:0019702 name: protein-arginine N5-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the delta-nitrogen atom of peptidyl-arginine residues. The reaction is S-adenosyl-L-methionine + [protein]-L-arginine = S-adenosyl-L-homocysteine + [protein]-N5-methyl-L-arginine." [EC:2.1.1.322, PMID:9873020] comment: This enzyme, characterized from the yeast Saccharomyces cerevisiae, methylates the delta-nitrogen atom of arginine residues within proteins. Among its substrates are Arg67 of the ribosomal protein L12. synonym: "protein-arginine delta-N-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:[protein]-L-arginine N-methyltransferase ([protein]-N5-methyl-L-arginine-forming)" EXACT [EC:2.1.1.322] synonym: "type IV PRMT activity" EXACT [] synonym: "type IV protein arginine methyltransferase activity" EXACT [] xref: EC:2.1.1.322 is_a: GO:0016274 ! protein-arginine N-methyltransferase activity [Term] id: GO:0019703 name: coenzyme A-peptidyl-cysteine covalent linking namespace: biological_process def: "The covalent linkage of coenzyme A and peptidyl-cysteine to form L-cysteine coenzyme A disulfide." [RESID:AA0306] xref: RESID:AA0306 is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019704 name: peptidyl-L-cysteine S-myristoylation namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-myristoyl-L-cysteine." [RESID:AA0307] synonym: "peptidyl-S-myristoyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine biosynthetic process from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-myristoyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0307 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018377 ! protein myristoylation [Term] id: GO:0019705 name: protein-cysteine S-myristoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a myristoyl group to a sulfur atom on a cysteine residue of a protein molecule." [GOC:ai] is_a: GO:0019107 ! myristoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019706 name: protein-cysteine S-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a palmitoyl group to a sulfur atom on the cysteine of a protein molecule." [EC:2.3.1.225, GOC:ai, GOC:pr] synonym: "protein-cysteine S-palmitoleyltransferase activity" RELATED [] xref: EC:2.3.1.225 xref: reactome:R-HSA-5682084 "ZDHCC8 transfers PALM from PALM-CoA to ABCA1 tetramer" is_a: GO:0016409 ! palmitoyltransferase activity is_a: GO:0019707 ! protein-cysteine S-acyltransferase activity [Term] id: GO:0019707 name: protein-cysteine S-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to a sulfur atom on the cysteine of a protein molecule." [GOC:ai] is_a: GO:0016417 ! S-acyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019708 name: peptidyl-glycine cholesteryl ester biosynthesis from peptidyl-glycine namespace: biological_process def: "The synthesis of peptidyl-glycine cholest-5-en-3-beta-ol ester at the carboxy-terminus of autolytically cleaved proteins." [RESID:AA0309] synonym: "peptidyl-glycine cholesteryl ester anabolism from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester formation from peptidyl-glycine" EXACT [] synonym: "peptidyl-glycine cholesteryl ester synthesis from peptidyl-glycine" EXACT [] xref: RESID:AA0309 is_a: GO:0006501 ! C-terminal protein lipidation is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0042398 ! cellular modified amino acid biosynthetic process [Term] id: GO:0019709 name: iron incorporation into iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide namespace: biological_process def: "The incorporation of iron into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase." [RESID:AA0310] synonym: "iron incorporation into iron-sulphur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulphide" EXACT [] xref: RESID:AA0310 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018202 ! peptidyl-histidine modification is_a: GO:0018283 ! iron incorporation into metallo-sulfur cluster [Term] id: GO:0019710 name: peptidyl-asparagine methylation namespace: biological_process alt_id: GO:0018018 def: "The methylation of peptidyl-asparagine to form peptidyl-N4-methyl-L-asparagine or peptidyl-N4,N4-dimethyl-L-asparagine." [RESID:AA0070, RESID:AA0311] xref: RESID:AA0070 xref: RESID:AA0311 is_a: GO:0018196 ! peptidyl-asparagine modification [Term] id: GO:0019711 name: peptidyl-beta-carboxyaspartic acid biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptidyl-beta-carboxyaspartic acid from other compounds, including peptidyl-aspartic acid." [GOC:go_curators] synonym: "peptidyl-beta-carboxyaspartic acid anabolism from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid formation from peptidyl-aspartic acid" EXACT [] synonym: "peptidyl-beta-carboxyaspartic acid synthesis from peptidyl-aspartic acid" EXACT [] is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019712 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamic acid namespace: biological_process def: "The methyl esterification of peptidyl-glutamic acid." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamic acid" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamic acid" EXACT [] xref: RESID:AA0072 is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine [Term] id: GO:0019713 name: peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from glutamine namespace: biological_process def: "The coupled methyl esterification and deamidation of peptidyl-glutamine." [RESID:AA0072] synonym: "peptidyl-L-glutamic acid 5-methyl ester anabolism from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester formation from glutamine" EXACT [] synonym: "peptidyl-L-glutamic acid 5-methyl ester synthesis from glutamine" EXACT [] xref: RESID:AA0072 is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0018390 ! peptidyl-L-glutamic acid 5-methyl ester biosynthetic process from peptidyl-glutamic acid or peptidyl-glutamine is_a: GO:0019714 ! peptidyl-glutamine esterification [Term] id: GO:0019714 name: peptidyl-glutamine esterification namespace: biological_process def: "The addition of an ester group to a glutamine residue in a protein." [GOC:mah] is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018350 ! protein esterification [Term] id: GO:0019715 name: peptidyl-aspartic acid hydroxylation to form L-erythro-beta-hydroxyaspartic acid namespace: biological_process def: "The hydroxylation of peptidyl-aspartic acid to form peptidyl-L-erythro-beta-hydroxyaspartic acid; catalyzed by peptide-aspartate beta-dioxygenase (EC:1.14.11.16)." [RESID:AA0027] comment: See also the molecular function term 'peptide-aspartate beta-dioxygenase activity ; GO:0004597'. xref: RESID:AA0027 is_a: GO:0042264 ! peptidyl-aspartic acid hydroxylation [Term] id: GO:0019716 name: N-terminal peptidyl-alanine monomethylation namespace: biological_process def: "The monomethylation of the N-terminal alanine of proteins to form the derivative peptidyl-N-methyl-L-alanine." [RESID:AA0061] xref: RESID:AA0061 is_a: GO:0018011 ! N-terminal peptidyl-alanine methylation [Term] id: GO:0019717 name: obsolete synaptosome namespace: cellular_component def: "OBSOLETE: Any of the discrete particles (nerve-ending particles) formed from the clublike presynaptic nerve endings that resist disruption and are snapped or torn off their attachments when brain tissue is homogenized in media isosmotic to plasma." [ISBN:0198506732] comment: This term was made obsolete because it refers to a result of cell homogenization and not a bona fide cellular component. synonym: "synaptosome" EXACT [] xref: Wikipedia:Synaptosome is_obsolete: true consider: GO:0043005 [Term] id: GO:0019718 name: obsolete rough microsome namespace: cellular_component def: "OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum membranes and studded with ribosomes on the outside." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "rough microsome" EXACT [] is_obsolete: true consider: GO:0005791 [Term] id: GO:0019719 name: obsolete smooth microsome namespace: cellular_component def: "OBSOLETE: Vesicular particles formed from disrupted endoplasmic reticulum and plasma membranes without any adhering ribosomes." [ISBN:0198506732] comment: This term was made obsolete because it refers to a cell fractionation experimental result and not a bona fide cellular component. synonym: "smooth microsome" EXACT [] is_obsolete: true consider: GO:0005790 [Term] id: GO:0019720 name: Mo-molybdopterin cofactor metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] synonym: "Mo-molybdopterin cofactor metabolism" EXACT [] synonym: "Moco metabolic process" BROAD [] synonym: "Moco metabolism" BROAD [] is_a: GO:0043545 ! molybdopterin cofactor metabolic process [Term] id: GO:0019722 name: calcium-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions." [GOC:signaling] synonym: "calcium ion signaling" EXACT [] synonym: "calcium signaling" EXACT [] synonym: "calcium signalling" EXACT [] synonym: "calcium-mediated signalling" EXACT [] xref: Wikipedia:Calcium_signaling is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019724 name: B cell mediated immunity namespace: biological_process def: "Any process involved with the carrying out of an immune response by a B cell, through, for instance, the production of antibodies or cytokines, or antigen presentation to T cells." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "B lymphocyte mediated immune effector process" EXACT [] synonym: "B lymphocyte mediated immunity" EXACT [] synonym: "B-cell mediated immune effector process" EXACT [] synonym: "B-cell mediated immunity" EXACT [] synonym: "B-lymphocyte mediated immune effector process" EXACT [] synonym: "B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0019725 name: cellular homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state at the level of the cell." [GOC:isa_complete, GOC:jl, ISBN:0395825172] subset: goslim_aspergillus subset: goslim_candida subset: goslim_plant is_a: GO:0009987 ! cellular process is_a: GO:0042592 ! homeostatic process [Term] id: GO:0019726 name: mevaldate reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NADP(+) = H(+) + mevaldate + NADPH." [EC:1.1.1.33, RHEA:20193] synonym: "(R)-mevalonate:NADP+ oxidoreductase" EXACT [EC:1.1.1.33] synonym: "mevaldate (reduced nicotinamide adenine dinucleotide phosphate) reductase" EXACT [EC:1.1.1.33] xref: EC:1.1.1.33 xref: KEGG:R02247 xref: MetaCyc:MEVALDATE-REDUCTASE-NADPH-RXN xref: RHEA:20193 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019727 name: mevaldate reductase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + NAD(+) = H(+) + mevaldate + NADH." [EC:1.1.1.32, RHEA:13221] xref: EC:1.1.1.32 xref: KEGG:R02246 xref: MetaCyc:MEVALDATE-REDUCTASE-RXN xref: RHEA:13221 is_a: GO:0004495 ! mevaldate reductase activity [Term] id: GO:0019728 name: peptidyl-allysine oxidation to 2-aminoadipic acid namespace: biological_process def: "The oxidation of allysine to 2-aminoadipic acid." [RESID:AA0122] xref: RESID:AA0370 is_a: GO:0018158 ! protein oxidation is_a: GO:0018205 ! peptidyl-lysine modification [Term] id: GO:0019729 name: peptide cross-linking via 2-imino-glutaminyl-5-imidazolinone glycine namespace: biological_process def: "The formation of the fluorescent protein FP583 chromophore cross-link from the alpha-carboxyl carbon of residue n, a glutamine, to the alpha-amino nitrogen of residue n+2, a glycine, and a dehydration to form a double bond to the alpha-amino nitrogen of residue n+1. This cross-linking is coupled with a dehydrogenation of residue n+1 to form a double bond between the alpha and beta carbons." [RESID:AA0189] comment: See also the biological process term 'peptidyl-tyrosine dehydrogenation ; GO:0018251'. synonym: "biosynthesis of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] synonym: "biosynthetic process of protein-protein cross-link via 2-imino-glutaminyl-5-imidazolinone glycine" EXACT [] xref: RESID:AA0189 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018199 ! peptidyl-glutamine modification is_a: GO:0018201 ! peptidyl-glycine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019730 name: antimicrobial humoral response namespace: biological_process alt_id: GO:0006960 alt_id: GO:0019735 def: "An immune response against microbes mediated through a body fluid. Examples of this process are seen in the antimicrobial humoral response of Drosophila melanogaster and Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0006959 ! humoral immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0019731 name: antibacterial humoral response namespace: biological_process alt_id: GO:0006961 alt_id: GO:0019733 def: "An immune response against bacteria mediated through a body fluid. Examples of this process are the antibacterial humoral responses in Mus musculus and Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0019732 name: antifungal humoral response namespace: biological_process alt_id: GO:0006966 alt_id: GO:0019734 def: "An immune response against a fungus mediated through a body fluid. An example of this process is the antifungal humoral response in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0019730 ! antimicrobial humoral response is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0019736 name: peptidyl-sarcosine incorporation namespace: biological_process def: "The incorporation of sarcosine (N-methylglycine) into non-coded peptides." [RESID:AA0063] xref: RESID:AA0063 is_a: GO:0018201 ! peptidyl-glycine modification [Term] id: GO:0019740 name: nitrogen utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary nitrogen source, usually ammonia, and then activates genes to scavenge the last traces of the primary nitrogen source and to transport and metabolize alternative nitrogen sources. The utilization process begins when the cell or organism detects nitrogen levels, includes the activation of genes whose products detect, transport or metabolize nitrogen-containing substances, and ends when nitrogen is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process [Term] id: GO:0019741 name: pentacyclic triterpenoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid breakdown" EXACT [] synonym: "pentacyclic triterpenoid catabolism" EXACT [] synonym: "pentacyclic triterpenoid degradation" EXACT [] is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0019742 name: pentacyclic triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid metabolism" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0019743 name: hopanoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid breakdown" EXACT [] synonym: "hopanoid catabolism" EXACT [] synonym: "hopanoid degradation" EXACT [] is_a: GO:0016105 ! triterpenoid catabolic process is_a: GO:0019744 ! hopanoid metabolic process [Term] id: GO:0019744 name: hopanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid metabolism" EXACT [] is_a: GO:0006722 ! triterpenoid metabolic process [Term] id: GO:0019745 name: pentacyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pentacyclic triterpenoid compounds, terpenoids with six isoprene units and 5 carbon rings." [ISBN:0198506732] synonym: "pentacyclic triterpenoid anabolism" EXACT [] synonym: "pentacyclic triterpenoid biosynthesis" EXACT [] synonym: "pentacyclic triterpenoid formation" EXACT [] synonym: "pentacyclic triterpenoid synthesis" EXACT [] is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:0019742 ! pentacyclic triterpenoid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0019746 name: hopanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hopanoids, pentacyclic sterol-like compounds based on the hopane nucleus." [ISBN:0198547684] synonym: "hopanoid anabolism" EXACT [] synonym: "hopanoid biosynthesis" EXACT [] synonym: "hopanoid formation" EXACT [] synonym: "hopanoid synthesis" EXACT [] is_a: GO:0016104 ! triterpenoid biosynthetic process is_a: GO:0019744 ! hopanoid metabolic process [Term] id: GO:0019747 name: regulation of isoprenoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving isoprenoids." [GOC:go_curators] synonym: "regulation of isoprenoid metabolism" EXACT [] is_a: GO:0019216 ! regulation of lipid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0006720 ! isoprenoid metabolic process [Term] id: GO:0019748 name: secondary metabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in many of the chemical changes of compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon. In multicellular organisms secondary metabolism is generally carried out in specific cell types, and may be useful for the organism as a whole. In unicellular organisms, secondary metabolism is often used for the production of antibiotics or for the utilization and acquisition of unusual nutrients." [GOC:go_curators] subset: goslim_aspergillus subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "secondary metabolism" EXACT [] synonym: "secondary metabolite metabolic process" EXACT [] synonym: "secondary metabolite metabolism" EXACT [] xref: Wikipedia:Secondary_metabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0019749 name: cytoskeleton-dependent cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of substances along cytoskeletal elements, such as microfilaments or microtubules, from a nurse cell to an oocyte." [GOC:ai] is_a: GO:0007303 ! cytoplasmic transport, nurse cell to oocyte is_a: GO:0030705 ! cytoskeleton-dependent intracellular transport [Term] id: GO:0019750 name: chloroplast localization namespace: biological_process def: "Any process in which a chloroplast is transported to, and/or maintained in, a specific location within the cell. A chloroplast is a chlorophyll-containing plastid found in cells of algae and higher plants." [GOC:bf, GOC:jl, ISBN:0198506732] synonym: "chloroplast localisation" EXACT [GOC:mah] is_a: GO:0051644 ! plastid localization [Term] id: GO:0019751 name: polyol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyol, any alcohol containing three or more hydroxyl groups attached to saturated carbon atoms." [CHEBI:26191, GOC:go_curators] synonym: "polyhydric alcohol metabolic process" EXACT [] synonym: "polyol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process [Term] id: GO:0019752 name: carboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [ISBN:0198506732] synonym: "carboxylic acid metabolism" EXACT [] is_a: GO:0043436 ! oxoacid metabolic process [Term] id: GO:0019755 name: one-carbon compound transport namespace: biological_process def: "The directed movement of one-carbon compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "one carbon compound transport" EXACT [] is_a: GO:0071702 ! organic substance transport [Term] id: GO:0019756 name: cyanogenic glycoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyanogenic glycosides, any glycoside containing a cyano group that is released as hydrocyanic acid on acid hydrolysis; such compounds occur in the kernels of various fruits." [ISBN:0198506732] synonym: "cyanogenic glycoside anabolism" EXACT [] synonym: "cyanogenic glycoside biosynthesis" EXACT [] synonym: "cyanogenic glycoside formation" EXACT [] synonym: "cyanogenic glycoside synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0042341 ! cyanogenic glycoside metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:0080028 ! nitrile biosynthetic process [Term] id: GO:0019757 name: glycosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate metabolism" EXACT [] is_a: GO:0016143 ! S-glycoside metabolic process is_a: GO:0019748 ! secondary metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0019758 name: glycosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate anabolism" EXACT [] synonym: "glycosinolate biosynthesis" EXACT [] synonym: "glycosinolate formation" EXACT [] synonym: "glycosinolate synthesis" EXACT [] is_a: GO:0016144 ! S-glycoside biosynthetic process is_a: GO:0019757 ! glycosinolate metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0019759 name: glycosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosinolates, substituted thioglycosides found in rapeseed products and related cruciferae." [GOC:mah, http://www.gardeneaters.net/family_characteristics.html] synonym: "glycosinolate breakdown" EXACT [] synonym: "glycosinolate catabolism" EXACT [] synonym: "glycosinolate degradation" EXACT [] is_a: GO:0016145 ! S-glycoside catabolic process is_a: GO:0019757 ! glycosinolate metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0019760 name: glucosinolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae. They are metabolized to a variety of toxic products which are most likely the cause of hepatocytic necrosis in animals and humans." [CHEBI:24279, GOC:curators] synonym: "glucosinolate metabolism" EXACT [] is_a: GO:0019757 ! glycosinolate metabolic process [Term] id: GO:0019761 name: glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] synonym: "glucosinolate anabolism" EXACT [] synonym: "glucosinolate biosynthesis" EXACT [] synonym: "glucosinolate formation" EXACT [] synonym: "glucosinolate synthesis" EXACT [] is_a: GO:0019758 ! glycosinolate biosynthetic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019762 name: glucosinolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [GOC:ai] synonym: "glucosinolate breakdown" EXACT [] synonym: "glucosinolate catabolism" EXACT [] synonym: "glucosinolate degradation" EXACT [] xref: MetaCyc:PWY-5267 is_a: GO:0019759 ! glycosinolate catabolic process is_a: GO:0019760 ! glucosinolate metabolic process [Term] id: GO:0019763 name: immunoglobulin receptor activity namespace: molecular_function alt_id: GO:0016489 def: "Combining with the Fc region of an immunoglobulin protein and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:signaling, ISBN:0198547684] synonym: "FC receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0019764 name: obsolete high affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is an unnecessary grouping term. synonym: "high affinity Fc receptor activity" EXACT [] is_obsolete: true consider: GO:0019768 consider: GO:0019771 [Term] id: GO:0019765 name: obsolete low affinity Fc receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it is undefined and is an unnecessary grouping term. synonym: "low affinity Fc receptor activity" EXACT [] is_obsolete: true consider: GO:0019769 consider: GO:0019772 [Term] id: GO:0019766 name: IgA receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgA isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0019767 name: IgE receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0019768 name: high-affinity IgE receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "high affinity Fc receptor activity" RELATED [] synonym: "high affinity IgE receptor activity" EXACT [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019769 name: low-affinity IgE receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of the IgE isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "low affinity Fc receptor activity" RELATED [] synonym: "low affinity IgE receptor activity" EXACT [] is_a: GO:0019767 ! IgE receptor activity [Term] id: GO:0019770 name: IgG receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0019771 name: high-affinity IgG receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "high affinity Fc receptor activity" RELATED [] synonym: "high affinity IgG receptor activity" EXACT [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019772 name: low-affinity IgG receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgG isotype via the Fc region, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] synonym: "low affinity Fc receptor activity" RELATED [] synonym: "low affinity IgG receptor activity" EXACT [] is_a: GO:0019770 ! IgG receptor activity [Term] id: GO:0019773 name: proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019774 name: proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the proteasome core complex. An example of this component is found in Mus musculus." [GOC:jl, GOC:mtg_sensu, GOC:rb, PMID:10854779] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005839 ! proteasome core complex [Term] id: GO:0019775 name: FAT10 transferase activity namespace: molecular_function def: "Catalysis of the transfer of FAT10 from one protein to another via the reaction X-FAT10 + Y --> Y-FAT10 + X, where both X-FAT10 and Y-FAT10 are covalent linkages." [GOC:dph, GOC:mah, PMID:12826404] synonym: "FAT10 conjugating enzyme activity" NARROW [] is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019776 name: Atg8 ligase activity namespace: molecular_function def: "Catalysis of the covalent attachment of the ubiquitin-like protein Atg8 to substrate molecules; phosphatidylethanolamine is a known substrate." [GOC:mah, PMID:12826404] synonym: "APG8 conjugating enzyme activity" EXACT [] synonym: "APG8 ligase activity" EXACT [] synonym: "Atg8 conjugating enzyme activity" EXACT [] xref: reactome:R-HSA-5681981 "ATG3 transfers LC3 from ATG7 to ATG3" is_a: GO:0016740 ! transferase activity [Term] id: GO:0019777 name: Atg12 transferase activity namespace: molecular_function def: "Catalysis of the transfer of ATG12 from one protein to another via the reaction X-ATG12 + Y --> Y-ATG12 + X, where both X-ATG12 and Y-ATG12 are covalent linkages." [GOC:mah, PMID:12826404] synonym: "APG12 conjugating enzyme activity" NARROW [] synonym: "APG12 ligase activity" NARROW [] synonym: "Atg12 conjugating enzyme activity" NARROW [] synonym: "Atg12 ligase activity" NARROW [] xref: reactome:R-HSA-5681999 "ATG10 transfers ATG12 from ATG7 to ATG10" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019778 name: Atg12 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG12, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG12 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019779 name: Atg8 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier APG8, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "APG7" EXACT [] synonym: "APG8 activating enzyme activity" RELATED [GOC:vw] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity is_a: GO:0016740 ! transferase activity [Term] id: GO:0019780 name: FAT10 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier FAT10, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019781 name: NEDD8 activating enzyme activity namespace: molecular_function alt_id: GO:0019944 def: "Catalysis of the initiation of the NEDD8 (RUB1) conjugation cascade." [PMID:12646924] synonym: "RUB1 activating enzyme activity" EXACT [] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019782 name: ISG15 activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the small ubiquitin-related modifier ISG15, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:mah] synonym: "UBE1L" NARROW [] is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019783 name: ubiquitin-like protein-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide or isopeptide bonds within small proteins such as ubiquitin or ubiquitin-like proteins (e.g. APG8, ISG15, NEDD8, SUMO), or between the small protein and a larger protein to which it has been conjugated." [GOC:ma, GOC:mah] synonym: "small conjugating protein-specific protease activity" EXACT [GOC:dph] synonym: "ubiquitin-like specific protease activity" NARROW [] synonym: "ubiquitin-like-protein-specific protease activity" NARROW [] is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0019784 name: NEDD8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of NEDD8, a small ubiquitin-related modifier, from previously neddylated substrates." [GOC:mah] synonym: "deneddylase activity" EXACT [GOC:dph] xref: reactome:R-HSA-5690808 "UCHL3, SENP8 cleave NEDD8" xref: reactome:R-HSA-8863723 "COP9 and TOR1 deneddylate STON2" xref: reactome:R-HSA-8956040 "COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes" xref: reactome:R-HSA-8956045 "COP9 signalosome deneddylates nuclear CRL4 E3 ubiquitin ligase complex" is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019785 name: ISG15-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ISG15, a small ubiquitin-related modifier, from previously modified substrates." [GOC:mah] xref: reactome:R-HSA-1678841 "Regulation of protein ISGylation by ISG15 deconjugating enzyme USP18" xref: reactome:R-HSA-5653786 "USP43 deISGylates ISG:K164,ISG:K168-PCNA" is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019786 name: Atg8-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of APG8, a small ubiquitin-related modifier." [GOC:mah] synonym: "APG8-PE hydrolase" RELATED [] synonym: "APG8-specific protease activity" RELATED [GOC:vw] is_a: GO:0019783 ! ubiquitin-like protein-specific protease activity [Term] id: GO:0019787 name: ubiquitin-like protein transferase activity namespace: molecular_function alt_id: GO:0008639 alt_id: GO:0008640 def: "Catalysis of the transfer of a ubiquitin-like from one protein to another via the reaction X-ULP + Y --> Y-ULP + X, where both X-ULP and Y-ULP are covalent linkages. ULP represents a ubiquitin-like protein." [GOC:mah, GOC:rn, PMID:10806345, PMID:10884686] subset: goslim_pir synonym: "E2" RELATED [] synonym: "E3" RELATED [dph:GOC] synonym: "small conjugating protein ligase activity" NARROW [GOC:dph] synonym: "small conjugating protein transferase activity" EXACT [GOC:dph] synonym: "small protein conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like conjugating enzyme activity" NARROW [] synonym: "ubiquitin-like-protein ligase activity" NARROW [] xref: reactome:R-HSA-5678490 "ATG16L1 complex transfers LC3 from ATG3 to PE" xref: reactome:R-HSA-688137 "RIP2 is K63 polyubiquitinated" is_a: GO:0016740 ! transferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0019788 name: NEDD8 transferase activity namespace: molecular_function alt_id: GO:0016976 alt_id: GO:0019945 alt_id: GO:0042295 def: "Catalysis of the transfer of NEDD8 from one protein to another via the reaction X-NEDD8 + Y --> Y-NEDD8 + X, where both X-NEDD8 and Y-NEDD8 are covalent linkages." [GOC:mah] synonym: "Hub1 conjugating enzyme activity" RELATED [] synonym: "NEDD8 conjugating enzyme activity" RELATED [] synonym: "RUB1 conjugating enzyme activity" RELATED [] xref: reactome:R-HSA-8951648 "NEDD8 covalently binds catalytic cysteine of UBA3:NAE1" xref: reactome:R-HSA-8951661 "Transfer of NEDD8 to AcM-UBE2M" xref: reactome:R-HSA-8951764 "Transfer of NEDD8 to AcM-UBE2F" xref: reactome:R-HSA-8952044 "AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex" xref: reactome:R-HSA-8952618 "AcM-UBE2M transfers NEDD8 to CRL1 E3 ubiquitin ligase complex" xref: reactome:R-HSA-8952638 "AcM-UBE2M transfers NEDD8 to CRL4 E3 ubiquitin ligase complex" xref: reactome:R-HSA-8956025 "AcM-UBE2M transfers NEDD8 to CUL9:RBX1" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019789 name: SUMO transferase activity namespace: molecular_function alt_id: GO:0016930 alt_id: GO:0019949 def: "Catalysis of the transfer of SUMO from one protein to another via the reaction X-SUMO + Y --> Y-SUMO + X, where both X-SUMO and Y-SUMO are covalent linkages." [GOC:rn, PMID:11031248, PMID:11265250] synonym: "SMT3 conjugating enzyme" RELATED [] synonym: "SUMO conjugating enzyme activity" RELATED [] xref: reactome:R-HSA-2993769 "Transfer of SUMO3 from E1 to UBE2I (UBC9)" xref: reactome:R-HSA-2993780 "Transfer of SUMO1 from E1 to UBE2I (UBC9)" xref: reactome:R-HSA-2993790 "Transfer of SUMO2 from E1 to UBE2I (UBC9)" xref: reactome:R-HSA-2997616 "PIAS1,4 SUMOylates BRCA1 with SUMO2,3" xref: reactome:R-HSA-2997706 "MDM2 SUMOylates TP53 with SUMO2,3" xref: reactome:R-HSA-2997709 "PIAS1,4 SUMOylates BRCA1 with SUMO1" xref: reactome:R-HSA-2997723 "PIAS4 SUMOylates TP53BP1 with SUMO1" xref: reactome:R-HSA-3000348 "RANBP2 SUMOylates SP100 with SUMO2" xref: reactome:R-HSA-3000383 "UBE2I, HDAC7 SUMOylate PML with SUMO1" xref: reactome:R-HSA-3000399 "RANBP2 SUMOylates SP100 with SUMO1" xref: reactome:R-HSA-3000411 "RANBP2 SUMOylates PML with SUMO2" xref: reactome:R-HSA-3000433 "SUMOylation of PML with SUMO3" xref: reactome:R-HSA-3000434 "PML, TRIM27, PIAS1,2-1 SUMOylate MDM2 with SUMO1" xref: reactome:R-HSA-3108203 "PRC1 SUMOylates CTBP1 with SUMO2,3" xref: reactome:R-HSA-3108209 "PRC1 SUMOylates CTBP1 with SUMO1" xref: reactome:R-HSA-3108212 "SMC5-SMC6 Complex SUMOylates Cohesin with SUMO1" xref: reactome:R-HSA-3232162 "PIAS3 SUMOylates MITF with SUMO1" xref: reactome:R-HSA-3234081 "SUMOylation of TFAP2A with SUMO1" xref: reactome:R-HSA-3234084 "SUMOylation of TFAP2B with SUMO1" xref: reactome:R-HSA-3234094 "SUMOylation of TFAP2C with SUMO1" xref: reactome:R-HSA-3247493 "PIAS1 SUMOylates SP3 with SUMO1" xref: reactome:R-HSA-3296126 "CBX4, UHRF2 SUMOylate ZNF131 with SUMO1" xref: reactome:R-HSA-3465545 "PIAS1,3,4 SUMOylate MTA1 with SUMO2,3" xref: reactome:R-HSA-3782535 "TRIM28 SUMOylates TRIM28:ZNF350 with SUMO1" xref: reactome:R-HSA-3899291 "SUMOylation of EP300 with SUMO1" xref: reactome:R-HSA-3900047 "SUMOylation of DDX17 with SUMO1" xref: reactome:R-HSA-3900070 "SUMOylation of MKL1 with SUMO1" xref: reactome:R-HSA-3900177 "SUMOylation of DDX5 with SUMO1" xref: reactome:R-HSA-3900194 "PIAS1 SUMOylates DDX5 with SUMO2" xref: reactome:R-HSA-3903017 "SUMOylation of PPARGC1A with SUMO1" xref: reactome:R-HSA-3927824 "PRC1 SUMOylates CASP8AP2 with SUMO1" xref: reactome:R-HSA-3927886 "SUMOylation of NCOR2 with SUMO1" xref: reactome:R-HSA-3927959 "SUMOylation of CREBBP with SUMO1" xref: reactome:R-HSA-3968362 "SUMOylation of PIAS4 with SUMO1" xref: reactome:R-HSA-3968414 "UBE2I (UBC9), PIAS1 SUMOylate FOXL2 with SUMO1" xref: reactome:R-HSA-4085296 "SUMOylation of NCOA1 with SUMO1" xref: reactome:R-HSA-4085318 "SUMOylation of NCOA2 with SUMO1" xref: reactome:R-HSA-4085331 "PIAS2-1 SUMOylates PARK7 with SUMO1" xref: reactome:R-HSA-4085347 "PIAS1 SUMOylates SAFB with SUMO1" xref: reactome:R-HSA-4085350 "SUMOylation of UBE2I with SUMO1" xref: reactome:R-HSA-4085372 "PIAS1 SUMOylates SAFB with SUMO2,3" xref: reactome:R-HSA-4085992 "SUMOylation of DAXX with SUMO1" xref: reactome:R-HSA-4085994 "TOPORS SUMOylates SIN3A with SUMO1" xref: reactome:R-HSA-4086036 "PIAS1,3 SUMOylate NRIP1 with SUMO1" xref: reactome:R-HSA-4086059 "SUMOylation of NPM1 with SUMO2,3" xref: reactome:R-HSA-4086083 "SUMOylation of ING2 with SUMO1" xref: reactome:R-HSA-4086088 "SUMOylation of NPM1 with SUMO1" xref: reactome:R-HSA-4090281 "PIAS1,2-1 SUMOylate HIC1 with SUMO1" xref: reactome:R-HSA-4090284 "SUMOylation of HIPK2 with SUMO1" xref: reactome:R-HSA-4090288 "PIAS1,3 SUMOylate MBD1 with SUMO1" xref: reactome:R-HSA-4090390 "PIAS1,2-1 SUMOylates AR with SUMO1" xref: reactome:R-HSA-4090408 "PIAS1,3 SUMOylate ESR1 with SUMO1" xref: reactome:R-HSA-4341016 "PIAS1 SUMOylates NR3C2 (Mineralcorticoid Receptor) with SUMO1" xref: reactome:R-HSA-4341025 "SUMOylation of NR3C1 (GR) with SUMO1" xref: reactome:R-HSA-4341048 "SUMOylation of RXRA with SUMO1" xref: reactome:R-HSA-4341070 "PIAS4 SUMOylates PPARA with SUMO1" xref: reactome:R-HSA-4341072 "SUMOylation of RARA with SUMO2" xref: reactome:R-HSA-4341073 "PIAS3 SUMOylates PGR with SUMO1" xref: reactome:R-HSA-4546385 "PIAS1,3 SUMOylates NR5A1 with SUMO2" xref: reactome:R-HSA-4546386 "PIAS1,3 SUMOylates NR5A1 with SUMO1" xref: reactome:R-HSA-4546387 "PIAS4 SUMOylates VDR with SUMO2" xref: reactome:R-HSA-4551604 "PIAS4 SUMOylates PARP1 with SUMO1" xref: reactome:R-HSA-4551616 "SUMOylation of RPA1 (RPA70) with SUMO2,3" xref: reactome:R-HSA-4551648 "SUMOylation of TDG with SUMO1" xref: reactome:R-HSA-4551649 "RANBP2 SUMOylates RANBP2 with SUMO1" xref: reactome:R-HSA-4551655 "CBX4 SUMOylates BMI1 in PRC1 with SUMO1" xref: reactome:R-HSA-4551661 "PIAS4 SUMOylates RNF168 with SUMO1" xref: reactome:R-HSA-4551679 "RANBP2 SUMOylates RANBP2 with SUMO2" xref: reactome:R-HSA-4551683 "SUMOylation of TOPORS with SUMO1" xref: reactome:R-HSA-4551721 "PIAS4 SUMOylates VHL with SUMO1" xref: reactome:R-HSA-4551724 "PIAS4 SUMOylates HERC2 with SUMO1" xref: reactome:R-HSA-4551727 "CBX4 SUMOylates CBX4 in PRC1 with SUMO1" xref: reactome:R-HSA-4551738 "SUMOylation of TDG with SUMO2,3" xref: reactome:R-HSA-4551768 "PIAS4 SUMOylates PARP1 with SUMO2,3" xref: reactome:R-HSA-4568846 "CDKN2A (p14-ARF) SUMOylates WRN with SUMO1" xref: reactome:R-HSA-4568848 "PIAS1,2-1 SUMOylates XRCC4 with SUMO1" xref: reactome:R-HSA-4568863 "SUMOylation of RAD52 with SUMO1" xref: reactome:R-HSA-4568914 "SUMOylation of BLM with SUMO2,3" xref: reactome:R-HSA-4570463 "CBX4 (Pc2) SUMOylates CETN2 with SUMO2,3" xref: reactome:R-HSA-4570467 "SUMOylation of NOP58 with SUMO1" xref: reactome:R-HSA-4570485 "SUMOylation of Histone H4 with SUMO3" xref: reactome:R-HSA-4570489 "SUMOylation of NOP58 with SUMO2" xref: reactome:R-HSA-4570493 "RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1" xref: reactome:R-HSA-4570496 "SUMOylation of Histone H4 with SUMO1" xref: reactome:R-HSA-4570499 "CBX4 (Pc2) SUMOylates HNRNPK with SUMO2" xref: reactome:R-HSA-4570528 "SUMOylation of XPC with SUMO1" xref: reactome:R-HSA-4570553 "SUMOylation of MDC1 with SUMO2,3" xref: reactome:R-HSA-4570554 "SUMOylation of MDC1 with SUMO1" xref: reactome:R-HSA-4615839 "PIAS1 SUMOylates SATB1 with SUMO2,3" xref: reactome:R-HSA-4615872 "RANBP2 SUMOylates HDAC4 with SUMO1" xref: reactome:R-HSA-4615873 "PIAS2-2 SUMOylates SUZ12 with SUMO1" xref: reactome:R-HSA-4615889 "SUMOylation of HDAC1 with SUMO1" xref: reactome:R-HSA-4615900 "PIAS1 SUMOylates SATB2 with SUMO3" xref: reactome:R-HSA-4615905 "PIAS1 SUMOylates SATB1 with SUMO1" xref: reactome:R-HSA-4615910 "SUMOylation of PCNA with SUMO1" xref: reactome:R-HSA-4615933 "SUMOylation of CBX5 with SUMO1" xref: reactome:R-HSA-4615987 "RANBP2 SUMOylates HDAC4 with SUMO2,3" xref: reactome:R-HSA-4616015 "SUMOylation of HDAC2 with SUMO1" xref: reactome:R-HSA-4641342 "SUMOylation of TOP2A with SUMO1" xref: reactome:R-HSA-4641345 "SUMOylation of TOP2B with SUMO1" xref: reactome:R-HSA-4641350 "PIAS4 SUMOylates TOP2A with SUMO2,3" xref: reactome:R-HSA-4641362 "SUMOylation of TOP1 with SUMO1" xref: reactome:R-HSA-4655355 "RANBP2 SUMOylates CDCA8 (Borealin) and PIAS3 SUMOylates AURKB (Aurora-B)" xref: reactome:R-HSA-4655374 "SUMOylation of DNMT3B with SUMO1" xref: reactome:R-HSA-4655431 "SUMOyation of DNMT1 with SUMO1" xref: reactome:R-HSA-4655440 "CBX4 (Pc2) SUMOylates DNMT3A with SUMO1" xref: reactome:R-HSA-4656914 "SUMOylation of NFKBIA with SUMO1" xref: reactome:R-HSA-4717461 "PIAS1,2-2 SUMOylate PPARG with SUMO1" xref: reactome:R-HSA-4717521 "PIAS1 SUMOylates NR2C1 (TR2)" xref: reactome:R-HSA-4719413 "PIAS2,3,4 SUMOylate RORA with SUMO2" xref: reactome:R-HSA-4719423 "PIAS2-2 SUMOylates THRA with SUMO3" xref: reactome:R-HSA-4719424 "PIAS1 SUMOylates THRB with SUMO1." xref: reactome:R-HSA-4719436 "PIAS2,3,4 SUMOylate RORA with SUMO1" xref: reactome:R-HSA-4719447 "PIAS2-2 SUMOylates THRA with SUMO1" xref: reactome:R-HSA-4719448 "PIAS1 SUMOylates THRB with SUMO3" xref: reactome:R-HSA-4720432 "HDAC4 SUMOylates NR1H2 (LXRbeta) with SUMO2,3" xref: reactome:R-HSA-4720446 "HDAC4 SUMOylates NR1H3 (LXRalpha) with SUMO2,3" xref: reactome:R-HSA-4755411 "PIAS4 SUMOylates IKBKG with SUMO1" xref: reactome:R-HSA-4755478 "TOPORS SUMOylates IKBKE with SUMO1" xref: reactome:R-HSA-4755479 "SUMOylation of NFKB2 with SUMO1" xref: reactome:R-HSA-4755494 "PIAS1,2-1 SUMOylate NR5A2 with SUMO1" xref: reactome:R-HSA-4755526 "PIAS4 SUMOylates NR4A2 with SUMO2,3" xref: reactome:R-HSA-4755536 "PIAS3 SUMOylates RELA with SUMO3" xref: reactome:R-HSA-5228508 "RANBP2 SUMOylates PML with SUMO1" xref: reactome:R-HSA-5228521 "PIAS1,4 SUMOylate CASP8AP2 with SUMO1" xref: reactome:R-HSA-5228523 "RANBP2 SUMOylates MDM2 with SUMO1" xref: reactome:R-HSA-5228525 "RANBP2 SUMOylates TOP2A with SUMO1" xref: reactome:R-HSA-5682607 "PIAS4 SUMOylates HERC2 with SUMO1 at DNA DSBs" xref: reactome:R-HSA-5684052 "PIAS4 SUMOylates MDC1" xref: reactome:R-HSA-6790454 "SUMOylation of XPC" xref: reactome:R-HSA-6804468 "PIAS1 SUMOylates SP3 with SUMO2" xref: reactome:R-HSA-6804485 "PIAS1 SUMOylates L3MBTL2 with SUMO2" xref: reactome:R-HSA-8956365 "ZBED1 (DREF) SUMOylates CHD3 with SUMO1" is_a: GO:0019787 ! ubiquitin-like protein transferase activity [Term] id: GO:0019790 name: obsolete ubiquitin-like hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "ubiquitin-like hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019791 name: obsolete FAT10 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "FAT10 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019792 name: obsolete APG12 hydrolase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it cannot be determined what its intended meaning was, because the term name is not found in the literature. synonym: "APG12 hydrolase activity" EXACT [] is_obsolete: true consider: GO:0019783 [Term] id: GO:0019793 name: obsolete ISG15 carrier activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of ISG15 (interferon-stimulated gene-15) from one side of the membrane to the other." [GOC:jl, http://www.copewithcytokines.de/] comment: This term was made obsolete because it is gene product-specific and has no annotations. synonym: "interferon-stimulated gene-15 carrier activity" NARROW [] synonym: "ISG15 carrier activity" EXACT [] is_obsolete: true [Term] id: GO:0019794 name: obsolete nonprotein amino acid metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid metabolic process" EXACT [] synonym: "nonprotein amino acid metabolism" EXACT [] is_obsolete: true replaced_by: GO:0006520 [Term] id: GO:0019795 name: obsolete nonprotein amino acid biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of any amino acid that does not normally occur as a constituent residue of proteins." [GOC:ma] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid anabolism" EXACT [] synonym: "nonprotein amino acid biosynthesis" EXACT [] synonym: "nonprotein amino acid biosynthetic process" EXACT [] synonym: "nonprotein amino acid formation" EXACT [] synonym: "nonprotein amino acid synthesis" EXACT [] is_obsolete: true replaced_by: GO:0008652 [Term] id: GO:0019796 name: obsolete nonprotein amino acid catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of any amino acid not found, or rarely found, in peptide linkage in proteins." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it was a grouping term that was poorly defined and did not provide a particularly meaningful grouping, since even for those amino acids commonly found in proteins, not all molecules necessarily end up incorporated into proteins. The term also violated the principle of positivity. synonym: "nonprotein amino acid breakdown" EXACT [] synonym: "nonprotein amino acid catabolic process" EXACT [] synonym: "nonprotein amino acid catabolism" EXACT [] synonym: "nonprotein amino acid degradation" EXACT [] is_obsolete: true replaced_by: GO:0009063 [Term] id: GO:0019797 name: procollagen-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-3-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.7] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.7] synonym: "procollagen-proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "proline,2-oxoglutarate 3-dioxygenase activity" EXACT [EC:1.14.11.7] synonym: "prolyl 3-hydroxylase activity" BROAD [EC:1.14.11.7] synonym: "prolyl-4-hydroxyprolyl-glycyl-peptide, 2-oxoglutarate: oxygen oxidoreductase, 3-hydroxylating activity" EXACT [EC:1.14.11.7] synonym: "protocollagen proline 3-hydroxylase activity" EXACT [EC:1.14.11.7] xref: EC:1.14.11.7 xref: KEGG:R03218 xref: MetaCyc:PROCOLLAGEN-PROLINE-3-DIOXYGENASE-RXN xref: reactome:R-HSA-1980233 "Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen" is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031544 ! peptidyl-proline 3-dioxygenase activity [Term] id: GO:0019798 name: procollagen-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2, EC:1.14.11.7, GOC:mah] xref: EC:1.14.11 is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0019799 name: tubulin N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + (alpha-tubulin) L-lysine = CoA + (alpha-tubulin) N6-acetyl-L-lysine." [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "acetyl-CoA:alpha-tubulin-lysine N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetylase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "alpha-tubulin N-acetyltransferase activity" EXACT [EC:2.3.1.108] synonym: "TAT activity" EXACT [EC:2.3.1.108] synonym: "tubulin acetyltransferase activity" EXACT [EC:2.3.1.108] xref: EC:2.3.1.108 xref: MetaCyc:TUBULIN-N-ACETYLTRANSFERASE-RXN is_a: GO:0061733 ! peptide-lysine-N-acetyltransferase activity [Term] id: GO:0019800 name: peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan namespace: biological_process def: "The formation of a cross-link between peptide chains mediated by a chondroitin 4-sulfate glycosaminoglycan that originates from a typical O-glycosidic link to serine of one chain; the other chain is esterified, via the alpha-carbon of its C-terminal Asp, to C-6 of an internal N-acetylgalactosamine of the glycosaminoglycan chain." [PMID:1898736, RESID:AA0219] synonym: "peptide cross-linking via chondroitin 4-sulphate glycosaminoglycan" EXACT [] xref: RESID:AA0219 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030204 ! chondroitin sulfate metabolic process [Term] id: GO:0019801 name: cyclization of asparagine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of asparagine to yield an L-aspartimide (otherwise known as alpha-aminosuccinimide) residue at the C-terminus of an excised intein during protein splicing." [RESID:AA0302] comment: See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. synonym: "cyclization of asparagine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0302 is_a: GO:0006528 ! asparagine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019802 name: cyclization of glutamine involved in intein-mediated protein splicing namespace: biological_process def: "The cyclization of glutamine to yield an L-glutamimide residue at the C-terminus of an excised intein during protein splicing." [GOC:dph, GOC:tb, RESID:AA0303] comment: Note that this term should not be confused with 'peptidyl-pyroglutamic acid biosynthesis, using glutaminyl-peptide cyclotransferase ; GO:0017186'. See also the biological process term 'intein-mediated protein splicing ; GO:0016539'. synonym: "cyclization of glutamine, during protein splicing" RELATED [GOC:dph, GOC:tb] xref: RESID:AA0303 is_a: GO:0006541 ! glutamine metabolic process relationship: part_of GO:0016539 ! intein-mediated protein splicing [Term] id: GO:0019803 name: peptidyl-aspartic acid carboxylation namespace: biological_process def: "The carboxylation of peptidyl-aspartic acid to form peptidyl-L-beta-carboxyaspartic acid." [RESID:AA0304] xref: RESID:AA0304 is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018214 ! protein carboxylation [Term] id: GO:0019804 name: obsolete quinolinate synthetase complex namespace: cellular_component def: "OBSOLETE. A heterodimer which acts as a quinolinate synthetase; quinolinate synthetase B (L-aspartate oxidase) catalyzes the oxidation of L-aspartate to L-iminoaspartate; quinolinate synthetase A condenses L-imidoaspartate and dihydroxyacetone to quinolinate." [UniProtKB:P10902] comment: This term was made obsolete because there is no evidence that a physical complex forms; although the phrase "quinolinate synthetase complex" is occasionally used in the literature, it refers to two enzymes that act as monomers. synonym: "quinolinate synthetase complex" EXACT [] is_obsolete: true consider: GO:0008743 consider: GO:0008987 [Term] id: GO:0019805 name: quinolinate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of quinolinate, the anion of quinolinic acid, also known as 2,3-pyridinedicarboxylic acid." [GOC:ai] synonym: "quinolinate anabolism" EXACT [] synonym: "quinolinate biosynthesis" EXACT [] synonym: "quinolinate formation" EXACT [] synonym: "quinolinate synthesis" EXACT [] is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046874 ! quinolinate metabolic process is_a: GO:0072525 ! pyridine-containing compound biosynthetic process [Term] id: GO:0019806 name: bromide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 R-H + 2 bromide + hydrogen peroxide = 2 R-Br + 2 H2O. Enzymes with this activity often accept other halide ions as substrates, including chloride and iodide." [EC:1.11.1.10] synonym: "bromoperoxidase activity" EXACT [] xref: EC:1.11.1 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0019807 name: aspartoacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acyl-L-aspartate + H2O = a fatty acid anion + L-aspartate." [EC:3.5.1.15] synonym: "acetyl-aspartic deaminase activity" EXACT [EC:3.5.1.15] synonym: "acylase II" RELATED [EC:3.5.1.15] synonym: "aminoacylase II activity" RELATED [EC:3.5.1.15] synonym: "N-acetylaspartate amidohydrolase activity" EXACT [EC:3.5.1.15] synonym: "N-acyl-L-aspartate amidohydrolase activity" EXACT [EC:3.5.1.15] xref: EC:3.5.1.15 xref: MetaCyc:ASPARTOACYLASE-RXN xref: reactome:R-HSA-5691507 "ASPA deacetylates NAA to acetate and L-aspartate" xref: RHEA:10872 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019808 name: polyamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with polyamines, organic compounds containing two or more amino groups." [GOC:ai] is_a: GO:0005488 ! binding [Term] id: GO:0019809 name: spermidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] is_a: GO:0019808 ! polyamine binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0019810 name: putrescine binding namespace: molecular_function def: "Interacting selectively and non-covalently with putrescine, 1,4-diaminobutane, the polyamine formed by decarboxylation of ornithine and the metabolic precursor of spermidine and spermine." [GOC:ai] is_a: GO:0019808 ! polyamine binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0019811 name: cocaine binding namespace: molecular_function def: "Interacting selectively and non-covalently with cocaine (2-beta-carbomethoxy-3-beta-benzoxytropane), an alkaloid obtained from dried leaves of the South American shrub Erythroxylon coca or by chemical synthesis." [GOC:jl, ISBN:0198506732] is_a: GO:0008144 ! drug binding is_a: GO:0070405 ! ammonium ion binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding [Term] id: GO:0019812 name: type I site-specific deoxyribonuclease complex namespace: cellular_component def: "A multisubunit complex composed of two copies of a restriction (R) subunit, two copies of a methylation (M) subunit, and one copy of a specificity (S) subunit. This complex recognizes specific short DNA sequences (through the S subunit), and binds to them. If the recognition site is hemimethylated, the complex acts as a methyltransferase which modifies the recognition site, using S-adenosylmethionine as the methyl donor. Only the M and S subunits are required for this reaction. If the complex binds to an unmethylated recognition site, then the complex translocates the DNA bidirectionally in an ATP-dependent manner. When the translocation is stalled by impact with another complex or unusual DNA structure, the enzyme functions as an endonuclease and cleavage of the DNA will occur, hundreds or thousands of base pairs away from the recognition site. These DNA restriction systems are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995, PMID:15788748] synonym: "type I restriction enzyme complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1905347 ! endodeoxyribonuclease complex [Term] id: GO:0019813 name: type III site-specific deoxyribonuclease complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of two subunits, Res and Mod, that functions as an endonuclease and cleaves DNA. Cleavage will only occur when there are two un-methylated copies of a specific recognition site in an inverse orientation on the DNA. Cleavage occurs at a specific distance away from one of the recognition sites. The Mod subunit can act alone as a methyltansferase. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] synonym: "type III restriction enzyme complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1905347 ! endodeoxyribonuclease complex [Term] id: GO:0019814 name: immunoglobulin complex namespace: cellular_component def: "A protein complex that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains, held together by disulfide bonds and sometimes complexed with additional proteins. An immunoglobulin complex may be embedded in the plasma membrane or present in the extracellular space, in mucosal areas or other tissues, or circulating in the blood or lymph." [GOC:add, GOC:jl, ISBN:0781765196] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. subset: goslim_pir synonym: "antibody" NARROW [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0019815 name: B cell receptor complex namespace: cellular_component alt_id: GO:0042570 def: "An immunoglobulin complex that is present in the plasma membrane of B cells and that in its canonical form is composed of two identical immunoglobulin heavy chains and two identical immunoglobulin light chains and a signaling subunit, a heterodimer of the Ig-alpha and Ig-beta proteins." [GOC:add, ISBN:0781735149] comment: Note that an immunoglobulin complex has the function of antigen binding if a suitable antigen is available. synonym: "antibody" RELATED [GOC:mah] synonym: "B cell receptor accessory molecule complex" RELATED [] synonym: "B lymphocyte receptor complex" EXACT [] synonym: "B-cell receptor complex" EXACT [] synonym: "B-lymphocyte receptor complex" EXACT [] synonym: "BCR complex" EXACT [] synonym: "immunoglobulin complex, membrane bound" EXACT [] is_a: GO:0019814 ! immunoglobulin complex is_a: GO:0098802 ! plasma membrane receptor complex [Term] id: GO:0019816 name: obsolete B cell receptor accessory molecule complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecule and not a location or complex. synonym: "B cell receptor accessory molecule complex" EXACT [] is_obsolete: true consider: GO:0019815 [Term] id: GO:0019817 name: vesicle fusion with peroxisome namespace: biological_process def: "The joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the peroxisome." [GOC:jid] is_a: GO:0006906 ! vesicle fusion relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0019819 name: P1 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P1 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they contain fewer peroxisomal proteins than the other subforms." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019820 name: P2 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P2 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content; they are the least dense of the subforms observed." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019821 name: P3 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P3 peroxisomes are formed by fusion of P1 and P2 peroxisomes, and are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P4 peroxisome ; GO:0019822', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019822 name: P4 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P4 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P5 peroxisome ; GO:0019823', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019823 name: P5 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P5 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P6 peroxisome ; GO:0019824'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019824 name: P6 peroxisome namespace: cellular_component def: "A subform of peroxisome that corresponds to an intermediate in a peroxisome assembly pathway, which operates by conversion of peroxisomal subforms in the direction P1, P2 -> P3 -> P4 -> P5 -> P6. P6 peroxisomes are distinguished from the other subforms on the bases of buoyant density and protein content, and are equivalent to mature peroxisomes." [PMID:10629216] comment: Note that this peroxisome assembly pathway is described in the yeast Yarrowia lipolytica. See also the cellular component terms 'P1 peroxisome ; GO:0019819', 'P2 peroxisome ; GO:0019820', 'P3 peroxisome ; GO:0019821', 'P4 peroxisome ; GO:0019822', and 'P5 peroxisome ; GO:0019823'. synonym: "peroxisome vesicle" BROAD [] is_a: GO:0005777 ! peroxisome [Term] id: GO:0019825 name: oxygen binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxygen (O2)." [GOC:jl] subset: goslim_pir subset: goslim_plant synonym: "cytochrome P450" NARROW [] synonym: "cytochrome P450 activity" RELATED [] is_a: GO:0008144 ! drug binding is_a: GO:0036094 ! small molecule binding [Term] id: GO:0019826 name: oxygen sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of oxygen (O2)." [GOC:mah] is_a: GO:0019825 ! oxygen binding is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0019827 name: stem cell population maintenance namespace: biological_process def: "The process by which an organism or tissue maintains a population of stem cells of a single type. This can be achieved by a number of mechanisms: stem cell asymmetric division maintains stem cell numbers; stem cell symmetric division increases them; maintenance of a stem cell niche maintains the conditions for commitment to the stem cell fate for some types of stem cell; stem cells may arise de novo from other cell types." [GOC:mah, ISBN:0878932437] synonym: "maintenance of pluripotency" RELATED [GOC:vk] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0098727 ! maintenance of cell number [Term] id: GO:0019828 name: aspartic-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of aspartic-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; the optimum reaction pH is below 5 due to an aspartic residue involved in the catalytic process." [GOC:ai] synonym: "aspartic protease inhibitor activity" NARROW [] is_a: GO:0004866 ! endopeptidase inhibitor activity [Term] id: GO:0019829 name: cation-transporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in)." [GOC:ai] synonym: "cation ABC transporter" NARROW [] synonym: "plasma membrane cation-transporting ATPase" NARROW [] xref: reactome:R-HSA-5251989 "ATP13A4,5 transport divalent ions from extracellular region to cytosol" xref: reactome:R-HSA-5692480 "ATP13A2 transports cations from cytosol to lysosomal lumen" is_a: GO:0022890 ! inorganic cation transmembrane transporter activity is_a: GO:0042625 ! ATPase coupled ion transmembrane transporter activity [Term] id: GO:0019830 name: obsolete cadmium sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "cadmium sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046686 [Term] id: GO:0019831 name: obsolete chromate sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "chromate sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046687 [Term] id: GO:0019832 name: obsolete mercuric sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "mercuric sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046689 [Term] id: GO:0019833 name: obsolete ice nucleation activity namespace: molecular_function def: "OBSOLETE. Catalysis of the formation of ice crystals in extracellular fluid at relatively high temperatures (up to -2 degrees C) to protect the organism from damage by intracellular ice formation. Ice nucleation proteins function by binding an ice crystal and then encouraging it to form larger crystals. Ice nucleation is a chemical process but these proteins can positively regulate it. There are two different uses of ice nucleation proteins: bacteria secrete them extracellularly to cause a host organism's cells to freeze and die, and fish use them to protect themselves from intracellular ice formation." [GOC:ai, GOC:jl] comment: This term was made obsolete because it represents a biological process. synonym: "ice nucleation activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0042309 consider: GO:0050825 [Term] id: GO:0019834 name: phospholipase A2 inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of the enzyme phospholipase A2." [GOC:ai] is_a: GO:0004859 ! phospholipase inhibitor activity [Term] id: GO:0019835 name: cytolysis namespace: biological_process def: "The rupture of cell membranes and the loss of cytoplasm." [UniProtKB-KW:KW-0204] subset: goslim_chembl synonym: "autolysin activity" RELATED [] synonym: "bacteriocin activity" RELATED [] synonym: "bacteriolytic toxin activity" RELATED [] synonym: "holin" RELATED [] synonym: "lysin activity" RELATED [] synonym: "lysis" BROAD [] synonym: "necrosis" RELATED [] xref: Wikipedia:Cytolysis is_a: GO:0009987 ! cellular process [Term] id: GO:0019836 name: hemolysis by symbiont of host erythrocytes namespace: biological_process def: "The cytolytic destruction of red blood cells, with the release of intracellular hemoglobin, in the host organism by a symbiont. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, UniProtKB-KW:KW-0354] synonym: "haemolysis in host" EXACT [] synonym: "hemolysin activity" RELATED [] synonym: "hemolysis by symbiont of host RBCs" EXACT [CL:0000232] synonym: "hemolysis by symbiont of host red blood cells" EXACT [CL:0000232] synonym: "regulation of cytolysis of host cells by symbiont" EXACT [GOC:dph, GOC:tb] is_a: GO:0001897 ! cytolysis by symbiont of host cells is_a: GO:0052331 ! hemolysis in other organism involved in symbiotic interaction [Term] id: GO:0019837 name: obsolete herbicide susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "herbicide susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0009635 [Term] id: GO:0019838 name: growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any growth factor, proteins or polypeptides that stimulate a cell or organism to grow or proliferate." [GOC:curators] subset: goslim_chembl synonym: "neurotrophin TRK receptor activity" RELATED [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019840 name: isoprenoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [GOC:jl] subset: goslim_pir is_a: GO:0008289 ! lipid binding [Term] id: GO:0019841 name: retinol binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinol, vitamin A1, 2,6,6-trimethyl-1-(9'-hydroxy-3',7'-dimethylnona-1',3',5',7'-tetraenyl)cyclohex-1-ene, one of the three components that makes up vitamin A. Retinol is an intermediate in the vision cycle and it also plays a role in growth and differentiation." [CHEBI:50211, GOC:curators] synonym: "vitamin A1 alcohol binding" EXACT [] synonym: "vitamin A1 binding" EXACT [] is_a: GO:0005501 ! retinoid binding is_a: GO:0019842 ! vitamin binding is_a: GO:0043178 ! alcohol binding [Term] id: GO:0019842 name: vitamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: goslim_metagenomics subset: goslim_pir is_a: GO:0036094 ! small molecule binding [Term] id: GO:0019843 name: rRNA binding namespace: molecular_function alt_id: GO:0000944 def: "Interacting selectively and non-covalently with ribosomal RNA." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "base pairing with rRNA" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0019844 name: obsolete endotoxin activity namespace: molecular_function def: "OBSOLETE. The function of any microbial toxin that cannot be easily separated from the structure of the cell." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "endotoxin activity" EXACT [] is_obsolete: true consider: GO:0005622 consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019845 name: obsolete exotoxin activity namespace: molecular_function def: "OBSOLETE. The function of a toxin formed by a microorganism and secreted into the surrounding medium." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "exotoxin activity" EXACT [] is_obsolete: true consider: GO:0005576 consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019846 name: obsolete enterotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to the intestinal mucosa of other living organisms." [ISBN:0198506732] comment: This term was made obsolete because it represents a class of gene products. synonym: "enterotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019847 name: obsolete neurotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another living organism." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. synonym: "neurotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019848 name: obsolete conotoxin activity namespace: molecular_function def: "OBSOLETE. Acts to inhibit neural function in another organism by inhibiting voltage-gated calcium ion channels and neurotransmitter release. This function is thought to be specific to the venom of two marine snail species." [GOC:jl, ISBN:0198506732] comment: This term was made obsolete because it represents a gene product. synonym: "conotoxin activity" EXACT [] is_obsolete: true consider: GO:0019855 consider: GO:0046929 [Term] id: GO:0019849 name: obsolete cytotoxin activity namespace: molecular_function def: "OBSOLETE. Acts as to cause injury to other living cells." [GOC:jl] comment: This term was made obsolete because it represents a class of gene products. synonym: "cytotoxin activity" EXACT [] is_obsolete: true consider: GO:0009405 consider: GO:0090729 [Term] id: GO:0019852 name: L-ascorbic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:jl, ISBN:0198506732] synonym: "ascorbate metabolic process" EXACT [] synonym: "ascorbate metabolism" EXACT [] synonym: "L-ascorbic acid metabolism" EXACT [] synonym: "vitamin C metabolic process" EXACT [] synonym: "vitamin C metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0019853 name: L-ascorbic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:ma, ISBN:0198547684] synonym: "ascorbate biosynthesis" EXACT [] synonym: "ascorbate biosynthetic process" EXACT [] synonym: "L-ascorbic acid anabolism" EXACT [] synonym: "L-ascorbic acid biosynthesis" EXACT [] synonym: "L-ascorbic acid formation" EXACT [] synonym: "L-ascorbic acid synthesis" EXACT [] synonym: "vitamin C biosynthesis" EXACT [] synonym: "vitamin C biosynthetic process" EXACT [] xref: MetaCyc:PWY-882 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0046364 ! monosaccharide biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0019854 name: L-ascorbic acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions." [CHEBI:38290, GOC:go_curators] synonym: "ascorbate catabolic process" EXACT [] synonym: "ascorbate catabolism" EXACT [] synonym: "L-ascorbic acid breakdown" EXACT [] synonym: "L-ascorbic acid catabolism" EXACT [] synonym: "L-ascorbic acid degradation" EXACT [] synonym: "vitamin C catabolic process" EXACT [] synonym: "vitamin C catabolism" EXACT [] xref: MetaCyc:PWY0-301 is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019852 ! L-ascorbic acid metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0046365 ! monosaccharide catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0019855 name: calcium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a calcium channel." [GOC:mah] is_a: GO:0005246 ! calcium channel regulator activity is_a: GO:0008200 ! ion channel inhibitor activity [Term] id: GO:0019856 name: pyrimidine nucleobase biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases." [CHEBI:26432, GOC:go_curators] synonym: "pyrimidine base anabolism" EXACT [] synonym: "pyrimidine base biosynthesis" EXACT [] synonym: "pyrimidine base biosynthetic process" EXACT [GOC:go_curators] synonym: "pyrimidine base formation" EXACT [] synonym: "pyrimidine base synthesis" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0072528 ! pyrimidine-containing compound biosynthetic process [Term] id: GO:0019857 name: 5-methylcytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 5-methylcytosine, a methylated base of DNA." [GOC:ai] synonym: "5-methylcytosine metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0072527 ! pyrimidine-containing compound metabolic process [Term] id: GO:0019858 name: cytosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:ai] synonym: "cytosine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0019859 name: thymine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] synonym: "thymine metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process [Term] id: GO:0019860 name: uracil metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] synonym: "uracil metabolism" EXACT [] is_a: GO:0006206 ! pyrimidine nucleobase metabolic process is_a: GO:0017144 ! drug metabolic process [Term] id: GO:0019861 name: obsolete flagellum namespace: cellular_component alt_id: GO:0008223 def: "OBSOLETE. Long whiplike or feathery structures borne either singly or in groups by the motile cells of many bacteria and unicellular eukaryotes and by the motile male gametes of many eukaryotic organisms, which propel the cell through a liquid medium." [UniProtKB-KW:KW-0282] comment: This term was made obsolete because it was an unnecessary grouping term. Eukaryotic flagella were deemed to be equivalent to cilia and merged, so the only remaining child to this term was 'bacterial-type flagellum ; GO:0009288'. synonym: "flagellum" EXACT [] xref: Wikipedia:Flagellum is_obsolete: true consider: GO:0005929 consider: GO:0009288 [Term] id: GO:0019862 name: IgA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgA isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019863 name: IgE binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgE isotype." [GOC:add, ISBN:0781735149] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019864 name: IgG binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of an IgG isotype." [GOC:add, ISBN:0781735149] subset: goslim_chembl is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0019865 name: immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin." [GOC:ma] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0019866 name: organelle inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of an organelle envelope; usually highly selective to most ions and metabolites." [GOC:mah] comment: See also the cellular component term 'outer membrane ; GO:0019867'. is_a: GO:0031090 ! organelle membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0019867 name: outer membrane namespace: cellular_component def: "The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites." [GOC:go_curators] subset: goslim_metagenomics is_a: GO:0016020 ! membrane [Term] id: GO:0019869 name: chloride channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a chloride channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017081 ! chloride channel regulator activity [Term] id: GO:0019870 name: potassium channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of a potassium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0015459 ! potassium channel regulator activity [Term] id: GO:0019871 name: sodium channel inhibitor activity namespace: molecular_function alt_id: GO:0019868 def: "Stops, prevents, or reduces the activity of a sodium channel." [GOC:mah] is_a: GO:0008200 ! ion channel inhibitor activity is_a: GO:0017080 ! sodium channel regulator activity [Term] id: GO:0019872 name: streptomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of streptomycin, a commonly used antibiotic in cell culture media; it acts only on prokaryotes and blocks transition from initiation complex to chain elongating ribosome." [CHEBI:17076, GOC:curators] synonym: "streptomycin anabolism" EXACT [] synonym: "streptomycin biosynthesis" EXACT [] synonym: "streptomycin formation" EXACT [] synonym: "streptomycin synthesis" EXACT [] is_a: GO:0030648 ! aminoglycoside antibiotic biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0046343 ! streptomycin metabolic process [Term] id: GO:0019873 name: obsolete tellurium sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. synonym: "tellurium sensitivity/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046690 [Term] id: GO:0019874 name: 6-aminohexanoate-cyclic-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1,8-diazacyclotetradecane-2,9-dione + H(2)O = N-(6-aminohexanoyl)-6-aminohexanoate." [EC:3.5.2.12, RHEA:16225] synonym: "1,8-diazacyclotetradecane-2,9-dione lactamhydrolase activity" EXACT [EC:3.5.2.12] xref: EC:3.5.2.12 xref: KEGG:R03448 xref: MetaCyc:3.5.2.12-RXN xref: RHEA:16225 xref: UM-BBD_reactionID:r1097 is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0019875 name: 6-aminohexanoate-dimer hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-(6-aminohexanoyl)-6-aminohexanoate + H2O = 2 6-aminohexanoate." [EC:3.5.1.46] synonym: "6-aminohexanoic acid oligomer hydrolase activity" EXACT [EC:3.5.1.46] synonym: "N-(6-aminohexanoyl)-6-aminohexanoate amidohydrolase activity" EXACT [EC:3.5.1.46] xref: EC:3.5.1.46 xref: MetaCyc:RXN-3962 xref: RHEA:21364 xref: UM-BBD_enzymeID:e0673 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0019876 name: nylon catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids." [UniProtKB-KW:KW-0549] synonym: "nylon breakdown" EXACT [] synonym: "nylon catabolism" EXACT [] synonym: "nylon degradation" EXACT [] is_a: GO:0042178 ! xenobiotic catabolic process is_a: GO:0042198 ! nylon metabolic process [Term] id: GO:0019877 name: diaminopimelate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diaminopimelate, both as an intermediate in lysine biosynthesis and as a component (as meso-diaminopimelate) of the peptidoglycan of Gram-negative bacterial cell walls." [GOC:ma, ISBN:0198547684] synonym: "diaminopimelate anabolism" EXACT [] synonym: "diaminopimelate biosynthesis" EXACT [] synonym: "diaminopimelate formation" EXACT [] synonym: "diaminopimelate synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0019878 name: lysine biosynthetic process via aminoadipic acid namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine by the aminoadipic pathway." [GOC:go_curators] synonym: "lysine anabolism via aminoadipic acid" EXACT [] synonym: "lysine biosynthesis, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthesis, aminoadipic pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic acid pathway" EXACT [] synonym: "lysine biosynthetic process, aminoadipic pathway" EXACT [] synonym: "lysine formation via aminoadipic acid" EXACT [] synonym: "lysine synthesis via aminoadipic acid" EXACT [] is_a: GO:0009085 ! lysine biosynthetic process [Term] id: GO:0019879 name: peptidyl-thyronine biosynthetic process from peptidyl-tyrosine namespace: biological_process def: "The formation of peptidyl-thyronine from peptidyl-tyrosine in thyroglobulin by phenyl transfer coupled with the formation of peptidyl-dehydroalanine." [GOC:jsg] comment: See also the biological process term 'peptidyl-dehydroalanine biosynthetic process from peptidyl-tyrosine or peptidyl-serine ; GO:0018250'. synonym: "peptidyl-thyronine anabolism from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine formation from peptidyl-tyrosine" EXACT [] synonym: "peptidyl-thyronine synthesis from peptidyl-tyrosine" EXACT [] is_a: GO:0018212 ! peptidyl-tyrosine modification is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0019880 name: obsolete bacteriocin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "bacteriocin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046678 [Term] id: GO:0019881 name: obsolete streptomycin susceptibility/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'susceptibility/resistance' implies a phenotype rather than a biological process. synonym: "streptomycin susceptibility/resistance" EXACT [] is_obsolete: true replaced_by: GO:0046679 [Term] id: GO:0019882 name: antigen processing and presentation namespace: biological_process alt_id: GO:0030333 def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149, PMID:15771591, PMID:15928678] comment: This term was improved by GO_REF:0000022. It was renamed and redefined. synonym: "antigen presentation" EXACT [] synonym: "antigen processing" EXACT [] xref: Wikipedia:Antigen_presentation is_a: GO:0002376 ! immune system process [Term] id: GO:0019883 name: antigen processing and presentation of endogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of endogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, endogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019884 name: antigen processing and presentation of exogenous antigen namespace: biological_process def: "The process in which an antigen-presenting cell expresses antigen (peptide or lipid) of exogenous origin on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149, PMID:15771591, PMID:15928678] synonym: "antigen presentation, exogenous antigen" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0019885 name: antigen processing and presentation of endogenous peptide antigen via MHC class I namespace: biological_process alt_id: GO:0048004 def: "The process in which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide antigen is typically, but not always, processed from a whole protein. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, endogenous peptide antigen" BROAD [] synonym: "antigen processing, endogenous antigen via major histocompatibility complex class I" BROAD [] synonym: "antigen processing, endogenous antigen via MHC class I" BROAD [] synonym: "endogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0019886 name: antigen processing and presentation of exogenous peptide antigen via MHC class II namespace: biological_process alt_id: GO:0042591 alt_id: GO:0048005 def: "The process in which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149, PMID:15771591] synonym: "antigen presentation, exogenous antigen via MHC class II" BROAD [] synonym: "antigen presentation, exogenous peptide antigen" BROAD [] synonym: "antigen processing, exogenous antigen via major histocompatibility complex class II" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0019887 name: protein kinase regulator activity namespace: molecular_function def: "Modulates the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019207 ! kinase regulator activity [Term] id: GO:0019888 name: protein phosphatase regulator activity namespace: molecular_function alt_id: GO:0008599 alt_id: GO:0008601 alt_id: GO:0030359 alt_id: GO:0030362 def: "Modulates the activity of a protein phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a protein substrate molecule." [GOC:ai] synonym: "calcineurin regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "calcineurin, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 2 regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 2, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 3 regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase 3, intrinsic regulator activity" NARROW [GOC:dph, GOC:rl] synonym: "protein phosphatase type 1 regulator activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 2A regulator activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 2B regulator activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic regulator activity" NARROW [] synonym: "protein phosphatase type 4 regulator activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic regulator activity" NARROW [] xref: reactome:R-HSA-180038 "DARPP-32 phosphorylated on T34 binds to PP1, inhibiting its function" is_a: GO:0019208 ! phosphatase regulator activity [Term] id: GO:0019889 name: pteridine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [GOC:go_curators, ISBN:0198506732] synonym: "pteridine metabolism" EXACT [] is_a: GO:0042558 ! pteridine-containing compound metabolic process [Term] id: GO:0019893 name: obsolete DNA replication inhibitor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA replication inhibitor" EXACT [] is_obsolete: true replaced_by: GO:0008156 [Term] id: GO:0019894 name: kinesin binding namespace: molecular_function def: "Interacting selectively and non-covalently and stoichiometrically with kinesin, a member of a superfamily of microtubule-based motor proteins that perform force-generating tasks such as organelle transport and chromosome segregation." [GOC:curators, PMID:8606779] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0019895 name: kinesin-associated mitochondrial adaptor activity namespace: molecular_function def: "The activity of linking kinesins, cytoplasmic proteins responsible for moving vesicles and organelles towards the distal end of microtubules, to mitochondria." [PMID:12495622] is_a: GO:0019894 ! kinesin binding is_a: GO:0030674 ! protein binding, bridging [Term] id: GO:0019896 name: axonal transport of mitochondrion namespace: biological_process def: "The directed movement of mitochondria along microtubules in nerve cell axons." [GOC:ai] subset: goslim_synapse synonym: "axon transport of mitochondria" EXACT [] is_a: GO:0047497 ! mitochondrion transport along microtubule is_a: GO:0098930 ! axonal transport [Term] id: GO:0019897 name: extrinsic component of plasma membrane namespace: cellular_component alt_id: GO:0000157 def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:curators, GOC:dos] synonym: "extrinsic to plasma membrane" EXACT [] synonym: "juxtamembrane" BROAD [] synonym: "peripheral plasma membrane protein" EXACT [] is_a: GO:0019898 ! extrinsic component of membrane is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0019898 name: extrinsic component of membrane namespace: cellular_component alt_id: GO:0030396 def: "The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:jl, GOC:mah] comment: Note that proteins extrinsic to membranes can be removed by treatments that do not disrupt the membrane, such as salt solutions. subset: goslim_metagenomics synonym: "extrinsic to membrane" EXACT [] synonym: "peripheral membrane protein" EXACT [] xref: Wikipedia:Peripheral_membrane_protein is_a: GO:0044425 ! membrane part [Term] id: GO:0019899 name: enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with any enzyme." [GOC:jl] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast is_a: GO:0005515 ! protein binding [Term] id: GO:0019900 name: kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kinase, any enzyme that catalyzes the transfer of a phosphate group." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019901 name: protein kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate." [GOC:jl] is_a: GO:0019900 ! kinase binding [Term] id: GO:0019902 name: phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any phosphatase." [GOC:jl] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0019903 name: protein phosphatase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein phosphatase." [GOC:jl] is_a: GO:0019902 ! phosphatase binding [Term] id: GO:0019904 name: protein domain specific binding namespace: molecular_function def: "Interacting selectively and non-covalently with a specific domain of a protein." [GOC:go_curators] subset: goslim_chembl synonym: "protein domain-specific binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019905 name: syntaxin binding namespace: molecular_function alt_id: GO:0030347 alt_id: GO:0030349 alt_id: GO:0050430 alt_id: GO:0051535 def: "Interacting selectively and non-covalently with a syntaxin, a SNAP receptor involved in the docking of synaptic vesicles at the presynaptic zone of a synapse." [ISBN:0198506732] synonym: "syntaxin-13 binding" NARROW [] synonym: "syntaxin-2 binding" NARROW [] synonym: "syntaxin-5 binding" NARROW [] synonym: "syntaxin-6 binding" NARROW [] is_a: GO:0000149 ! SNARE binding [Term] id: GO:0019907 name: cyclin-dependent protein kinase activating kinase holoenzyme complex namespace: cellular_component def: "A cyclin-dependent kinase activating kinase complex capable of activating cyclin-dependent kinases by threonine phosphorylation, thus regulating cell cycle progression. consists of a kinase, cyclin and optional assembly factors, in human CDK7, CCNH and MNAT1. CAK activity is itself regulated throughout the cell cycle by T-loop phosphorylation of its kinase component (CDK7 in human). Phosphorylation of serine residues during mitosis inactivates the enzyme. Also capable of CAK phosphorylating the carboxyl-terminal domain (CTD) of RNA polymerase II and other transcription activating proteins, as part of the general transcription factor TFIIH." [GOC:bhm, PMID:8752210] synonym: "CAK complex" EXACT [] synonym: "CDK-activating kinase complex" EXACT [] xref: IntAct:EBI-1246076 xref: IntAct:EBI-9868598 is_a: GO:0019908 ! nuclear cyclin-dependent protein kinase holoenzyme complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex is_a: GO:0150005 ! enzyme activator complex [Term] id: GO:0019908 name: nuclear cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the nucleus." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0019909 name: [pyruvate dehydrogenase (lipoamide)] phosphatase regulator activity namespace: molecular_function def: "Modification of the activity of the enzyme [pyruvate dehydrogenase (lipoamide)] phosphatase." [EC:3.1.3.43, GOC:ai] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0019910 name: mitochondrial pyruvate dehydrogenase (lipoamide) phosphatase complex namespace: cellular_component def: "A mitochondrial complex of a regulatory and catalytic subunit that catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex. An example of this component is found in Mus musculus." [GOC:mtg_sensu, PMID:9395502] comment: See also the cellular component term 'mitochondrial pyruvate dehydrogenase complex ; GO:0005967'. is_a: GO:0045253 ! pyruvate dehydrogenase (lipoamide) phosphatase complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0019911 name: structural constituent of myelin sheath namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the myelin sheath of a nerve." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0019912 name: cyclin-dependent protein kinase activating kinase activity namespace: molecular_function alt_id: GO:0019913 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; increases the activity of a cyclin-dependent protein kinase (CDK)." [GOC:go_curators] synonym: "CAK" EXACT [] synonym: "cdk-activating kinase activity" EXACT [] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic catalyst activity" EXACT [] xref: EC:2.7.11 is_a: GO:0004672 ! protein kinase activity is_a: GO:0030295 ! protein kinase activator activity [Term] id: GO:0019914 name: cyclin-dependent protein kinase activating kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cyclin-dependent protein kinase activating kinase." [GOC:ai] synonym: "cyclin-dependent protein kinase activating kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1 is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0019915 name: lipid storage namespace: biological_process def: "The accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development." [GOC:dph, GOC:mah, GOC:tb, PMID:11102830] synonym: "lipid retention" EXACT [GOC:dph, GOC:tb] synonym: "lipid sequestering" NARROW [GOC:dph, GOC:tb] synonym: "lipid sequestration" NARROW [GOC:dph, GOC:tb] synonym: "retention of lipids" EXACT [GOC:dph, GOC:tb] synonym: "sequestering of lipids" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipid" NARROW [GOC:dph, GOC:tb] synonym: "sequestration of lipids" EXACT [GOC:dph, GOC:tb] synonym: "storage of lipids" EXACT [] is_a: GO:0051235 ! maintenance of location relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0019916 name: peptidyl-D-alanine racemization, direct namespace: biological_process def: "The racemization of peptidyl-alanine." [RESID:AA0191] xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019917 name: peptidyl-D-alanine racemization via peptidyl-L-serine namespace: biological_process def: "The dehydration of peptidyl-serine, followed by hydrogenation to produce peptidyl-D-alanine." [RESID:AA0191] xref: RESID:AA0191 is_a: GO:0019122 ! peptidyl-D-alanine racemization [Term] id: GO:0019918 name: peptidyl-arginine methylation, to symmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N'(omega)-dimethyl-L-arginine." [RESID:AA0067, RESID:AA0069] xref: RESID:AA0067 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019919 name: peptidyl-arginine methylation, to asymmetrical-dimethyl arginine namespace: biological_process def: "The process of methylation of peptidyl-arginine to form peptidyl-N(omega),N(omega)-dimethyl-L-arginine." [RESID:AA0068, RESID:AA0069] synonym: "peptidyl-arginine methylation, to unsymmetrical-dimethyl arginine" EXACT [] xref: RESID:AA0068 xref: RESID:AA0069 is_a: GO:0035247 ! peptidyl-arginine omega-N-methylation [Term] id: GO:0019920 name: peptidyl-1-thioglycine biosynthetic process, internal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of internal peptidyl-1-thioglycine, which has an internal C=S bond, instead of an internal C=O bond, in the peptide." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism, internal" EXACT [] synonym: "peptidyl-1-thioglycine formation, internal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, internal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019921 name: peptidyl-1-thioglycine biosynthetic process, carboxy-terminal namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of carboxy-terminal peptidyl-1-thioglycine, which has a carboxy-terminal thiocarboxy-C(=O)-SH bond." [GOC:go_curators, http://www.uni-marburg.de/mpi/thauer/thauer_res.html, RESID:AA0265] synonym: "peptidyl-1-thioglycine anabolism, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine formation, carboxy-terminal" EXACT [] synonym: "peptidyl-1-thioglycine synthesis, carboxy-terminal" EXACT [] xref: RESID:AA0265 is_a: GO:0018173 ! peptidyl-1-thioglycine biosynthetic process from peptidyl-glycine [Term] id: GO:0019922 name: protein-chromophore linkage via peptidyl-cysteine namespace: biological_process def: "The covalent linking of a chromophore to a protein via peptidyl-cysteines." [GOC:ma] is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019923 name: alpha-1-microglobulin-chromophore linkage namespace: biological_process def: "The covalent linking of the alpha-1-microglobulin chromophore to the protein; the structure of the chromophore is not known. It is probably heterogeneous and involving two cysteines in thioether bonds." [RESID:AA0224] xref: RESID:AA0224 is_a: GO:0019922 ! protein-chromophore linkage via peptidyl-cysteine [Term] id: GO:0019926 name: peptidyl-tryptophan oxidation to tryptophyl quinone namespace: biological_process def: "The oxidation of peptidyl-tryptophan to form tryptophan-6,7-dione, otherwise known as tryptophyl quinone, which is further modified by cross-linking to either tryptophan or cysteine." [PMID:2028257, RESID:AA0148] comment: See also the biological process term 'peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone ; GO:0018069'. is_a: GO:0018158 ! protein oxidation is_a: GO:0018211 ! peptidyl-tryptophan modification relationship: part_of GO:0018069 ! peptide cross-linking via 4'-(L-tryptophan)-L-tryptophyl quinone [Term] id: GO:0019927 name: peptide cross-linking via 4'-(S-L-cysteinyl)-L-tryptophyl quinone namespace: biological_process def: "The cross-linking of a cysteine residue to tryptophyl quinone to form 4'-(S-L-cysteinyl)-L-tryptophyl quinone, a cofactor found at the active site of amine dehydrogenase." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0313] xref: RESID:AA0313 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019928 name: peptide cross-linking via 3-(S-L-cysteinyl)-L-aspartic acid namespace: biological_process def: "The cross-linking of a cysteine residue to an aspartic acid residue to form 3-(S-L-cysteinyl)-L-aspartic acid." [PDB:1JJU, PMID:11555656, PMID:11717396, RESID:AA0314] xref: RESID:AA0314 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018197 ! peptidyl-aspartic acid modification is_a: GO:0018198 ! peptidyl-cysteine modification [Term] id: GO:0019929 name: peptide cross-linking via 4-(S-L-cysteinyl)-L-glutamic acid namespace: biological_process def: "The cross-linking of a cysteine residue to a glutamic acid residue to form 4-(S-L-cysteinyl)-L-glutamic acid." [RESID:AA0315] xref: RESID:AA0315 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0018200 ! peptidyl-glutamic acid modification [Term] id: GO:0019930 name: cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester biosynthetic process from peptidyl-aspartic acid namespace: biological_process def: "The modification of peptidyl-aspartic acid to form peptidyl-cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid aspartate ester, typical of the barley lipid transfer protein 1." [RESID:AA0316] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester anabolism from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester formation from peptidyl-aspartic acid" EXACT [] synonym: "cis-14-hydroxy-10,13-dioxo-7-heptadecenoic acid peptidyl-aspartate ester synthesis from peptidyl-aspartic acid" EXACT [] xref: RESID:AA0316 is_a: GO:0018197 ! peptidyl-aspartic acid modification [Term] id: GO:0019931 name: protein-chromophore linkage via peptidyl-N6-3-dehydroretinal-L-lysine namespace: biological_process def: "The modification of peptidyl-lysine to form N6-3,4-didehydroretinylidene-L-lysine." [RESID:AA0312] xref: RESID:AA0312 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0018298 ! protein-chromophore linkage [Term] id: GO:0019932 name: second-messenger-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via a second messenger; a small molecule or ion that can be quickly generated or released from intracellular stores, and can diffuse within the cell. Second-messenger signaling includes production or release of the second messenger, and effectors downstream of the second messenger that further transmit the signal within the cell." [GOC:signaling, ISBN:0815316194, PMID:15221855, Wikipedia:Second_messenger_system] synonym: "second messenger mediated signaling" EXACT [] synonym: "second messenger mediated signalling" EXACT [] synonym: "second messenger-mediated signaling" EXACT [] synonym: "second messenger-mediated signalling" EXACT [] synonym: "second-messenger-mediated signal transduction" EXACT [GOC:signaling] synonym: "second-messenger-mediated signalling" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0019933 name: cAMP-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic AMP (cAMP). Includes production of cAMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "3',5' cAMP-mediated signaling" EXACT [] synonym: "3',5' cAMP-mediated signalling" EXACT [] synonym: "3',5'-cAMP-mediated signaling" EXACT [] synonym: "3',5'-cAMP-mediated signalling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signaling" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-mediated signalling" EXACT [] synonym: "cAMP signaling" EXACT [] synonym: "cAMP signalling" EXACT [] synonym: "cAMP-mediated signal transduction" EXACT [] synonym: "cAMP-mediated signalling" EXACT [] synonym: "cyclic AMP-mediated signaling" EXACT [] synonym: "cyclic AMP-mediated signalling" EXACT [] is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019934 name: cGMP-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via cyclic GMP (cGMP). Includes production of cGMP, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "cGMP-mediated signalling" EXACT [] is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0019935 name: cyclic-nucleotide-mediated signaling namespace: biological_process def: "Any intracellular signal transduction in which the signal is passed on within the cell via a cyclic nucleotide. Includes production or release of the cyclic nucleotide, and downstream effectors that further transmit the signal within the cell." [GOC:signaling] synonym: "cyclic-nucleotide-mediated signalling" EXACT [] is_a: GO:0019932 ! second-messenger-mediated signaling [Term] id: GO:0019936 name: obsolete inositol phospholipid-mediated signaling namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ceb] comment: This term was made obsolete because it did not adequately describe phosphoinositide-mediated signaling. synonym: "inositol phospholipid-mediated signaling" EXACT [] synonym: "inositol phospholipid-mediated signalling" EXACT [] is_obsolete: true consider: GO:0048016 consider: GO:0048017 [Term] id: GO:0019937 name: protein catenane formation via N6-(L-isoaspartyl)-L-lysine, autocatalytic namespace: biological_process def: "The autocatalytic formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; known to occur in the capsid of some bacteriophage, such as HK97, where it is thought to provide a mechanism for stabilizing the capsid." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018419 ! protein catenane formation is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019938 name: peptide cross-linking via N6-(L-isoaspartyl)-L-lysine, presumed catalytic namespace: biological_process alt_id: GO:0042266 def: "The formation of isopeptide bonds by ligation of peptidyl-lysine and peptidyl-asparagine residues; occurs in mammals in proteins as yet unidentified by a mechanism probably analogous to that of transglutaminase reactions." [RESID:AA0294] xref: RESID:AA0294 is_a: GO:0018420 ! peptide cross-linking via N6-(L-isoaspartyl)-L-lysine [Term] id: GO:0019939 name: peptidyl-S-palmitoleyl-L-cysteine biosynthetic process from peptidyl-cysteine namespace: biological_process def: "The modification of peptidyl-cysteine to form peptidyl-S-palmitoleyl-L-cysteine specifically." [RESID:AA0308] synonym: "peptidyl-S-palmitoleyl-L-cysteine anabolism from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine formation from peptidyl-cysteine" EXACT [] synonym: "peptidyl-S-palmitoleyl-L-cysteine synthesis from peptidyl-cysteine" EXACT [] xref: RESID:AA0308 is_a: GO:0018198 ! peptidyl-cysteine modification is_a: GO:0045234 ! protein palmitoleylation [Term] id: GO:0019940 name: obsolete SUMO-dependent protein catabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not reflect an accurate biological process, as sumoylation of a protein does not lead to catabolism of that protein. synonym: "SUMO-dependent protein breakdown" EXACT [] synonym: "SUMO-dependent protein catabolic process" EXACT [] synonym: "SUMO-dependent protein catabolism" EXACT [] synonym: "SUMO-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0016925 consider: GO:0016926 [Term] id: GO:0019941 name: modification-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent modification of the target protein." [GOC:go_curators] synonym: "modification-dependent protein breakdown" EXACT [] synonym: "modification-dependent protein catabolism" EXACT [] synonym: "modification-dependent protein degradation" EXACT [] synonym: "modification-dependent proteolysis" EXACT [GOC:rl] synonym: "modification-initiated protein catabolic process" EXACT [GOC:rl] synonym: "modification-initiated protein catabolism" EXACT [GOC:rl] synonym: "modification-initiated proteolysis" EXACT [GOC:rl] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein-ligand-dependent protein catabolic process" NARROW [] synonym: "protein-ligand-dependent protein catabolism" NARROW [] is_a: GO:0043632 ! modification-dependent macromolecule catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0019942 name: obsolete NEDD8 class-dependent protein catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein NEDD8 (RUB1) to the target protein." [GOC:jl] comment: This term was made obsolete because NEDD8-class tags do not target proteins for proteolytic destruction. synonym: "NEDD8 class-dependent protein breakdown" EXACT [] synonym: "NEDD8 class-dependent protein catabolic process" EXACT [] synonym: "NEDD8 class-dependent protein catabolism" EXACT [] synonym: "NEDD8 class-dependent protein degradation" EXACT [] synonym: "RUB1-dependent protein catabolic process" EXACT [] synonym: "RUB1-dependent protein catabolism" EXACT [] synonym: "RUB1-dependent protein degradation" EXACT [] is_obsolete: true consider: GO:0045116 [Term] id: GO:0019948 name: SUMO activating enzyme activity namespace: molecular_function alt_id: GO:0017115 def: "Catalysis of the activation of the proteolytically processed small ubiquitin-related modifier SUMO, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:rn, PMID:10187858, PMID:11265250] synonym: "SMT3 activating enzyme" EXACT [] synonym: "SUMO E1 activator enzyme" EXACT [] xref: reactome:R-HSA-2990833 "Conjugation of SUMO1 to UBA2:SAE1" xref: reactome:R-HSA-2993781 "Conjugation of SUMO3 to UBA2:SAE1" xref: reactome:R-HSA-2993784 "Conjugation of SUMO2 to UBA2:SAE1" is_a: GO:0008641 ! ubiquitin-like modifier activating enzyme activity [Term] id: GO:0019950 name: SMT3-dependent protein catabolic process namespace: biological_process alt_id: GO:0019946 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by covalent attachment of the ubiquitin-like protein SMT3 to the target protein." [GOC:jl, PMID:9435231] synonym: "SMT3-dependent protein breakdown" EXACT [] synonym: "SMT3-dependent protein catabolism" EXACT [] synonym: "SMT3-dependent protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0019951 name: Smt3-protein conjugation namespace: biological_process alt_id: GO:0019947 def: "The covalent addition to a protein of Smt3, a ubiquitin-like protein." [GOC:jl] synonym: "Smt3p-protein conjugation" EXACT [] is_a: GO:0032446 ! protein modification by small protein conjugation relationship: part_of GO:0019950 ! SMT3-dependent protein catabolic process [Term] id: GO:0019953 name: sexual reproduction namespace: biological_process def: "A reproduction process that creates a new organism by combining the genetic material of two gametes, which may come from two organisms or from a single organism, in the case of self-fertilizing hermaphrodites, e.g. C. elegans, or self-fertilization in plants. It occurs both in eukaryotes and prokaryotes: in multicellular eukaryotic organisms, an individual is created anew; in prokaryotes, the initial cell has additional or transformed genetic material. In a process called genetic recombination, genetic material (DNA) originating from two gametes join up so that homologous sequences are aligned with each other, and this is followed by exchange of genetic information. After the new recombinant chromosome is formed, it is passed on to progeny." [GOC:jl, GOC:kmv, GOC:krc, GOC:tb, http://en.wikipedia.org/wiki/Sexual_reproduction, ISBN:0387520546] comment: Sexual reproduction may be seen as the regular alternation, in the life cycle of haplontic, diplontic and diplohaplontic organisms, of meiosis and fertilization which provides for the production offspring. In diplontic organisms there is a life cycle in which the products of meiosis behave directly as gametes, fusing to form a zygote from which the diploid, or sexually reproductive polyploid, adult organism will develop. In diplohaplontic organisms a haploid phase (gametophyte) exists in the life cycle between meiosis and fertilization (e.g. higher plants, many algae and Fungi); the products of meiosis are spores that develop as haploid individuals from which haploid gametes develop to form a diploid zygote; diplohaplontic organisms show an alternation of haploid and diploid generations. In haplontic organisms meiosis occurs in the zygote, giving rise to four haploid cells (e.g. many algae and protozoa), only the zygote is diploid and this may form a resistant spore, tiding organisms over hard times. xref: Wikipedia:Sexual_reproduction is_a: GO:0000003 ! reproduction is_a: GO:0044703 ! multi-organism reproductive process [Term] id: GO:0019954 name: asexual reproduction namespace: biological_process def: "The biological process in which new individuals are produced by either a single cell or a group of cells, in the absence of any sexual process." [ISBN:0387520546] synonym: "parthenogenesis" RELATED [https://en.wikipedia.org/wiki/Parthenogenesis] xref: Wikipedia:Asexual_reproduction is_a: GO:0000003 ! reproduction [Term] id: GO:0019955 name: cytokine binding namespace: molecular_function alt_id: GO:0019965 def: "Interacting selectively and non-covalently with a cytokine, any of a group of proteins that function to control the survival, growth and differentiation of tissues and cells, and which have autocrine and paracrine activity." [GOC:ai, GOC:bf, ISBN:0198599471] synonym: "IL binding" NARROW [] synonym: "interleukin binding" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0019956 name: chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chemokine. Chemokines are a family of small chemotactic cytokines; their name is derived from their ability to induce directed chemotaxis in nearby responsive cells. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria." [GOC:ai, GOC:BHF, GOC:rl, http://en.wikipedia.org/wiki/Chemokine, PMID:12183377] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019957 name: C-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-C chemokine; C-C chemokines do not have an amino acid between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019958 name: C-X-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X-C chemokine; C-X-C chemokines have a single amino acid between the first two cysteines of the characteristic four cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019959 name: interleukin-8 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-8." [GOC:jl] synonym: "IL-8 binding" EXACT [] is_a: GO:0019958 ! C-X-C chemokine binding [Term] id: GO:0019960 name: C-X3-C chemokine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C-X3-C chemokine; C-X3-C chemokines have three amino acids between the first two cysteines of the characteristic four-cysteine motif." [GOC:ai] is_a: GO:0019956 ! chemokine binding [Term] id: GO:0019961 name: interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with an interferon, a protein produced by the immune systems of many animals in response to a challenge by a foreign agent." [PMID:9607096, Wikipedia:Interferon] synonym: "IFN binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019962 name: type I interferon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type I interferon. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha binding" NARROW [] synonym: "interferon-alpha/beta binding" NARROW [] synonym: "interferon-beta binding" NARROW [] synonym: "interferon-delta binding" NARROW [] synonym: "interferon-epsilon binding" NARROW [] synonym: "interferon-kappa binding" NARROW [] synonym: "interferon-omega binding" NARROW [] synonym: "interferon-tau binding" NARROW [] synonym: "interferon-zeta binding" NARROW [] synonym: "type I IFN binding" EXACT [GOC:mah] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019964 name: interferon-gamma binding namespace: molecular_function def: "Interacting selectively and non-covalently with interferon-gamma. Interferon gamma is the only member of the type II interferon found so far." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383, PR:000000017] synonym: "IFN-gamma binding" EXACT [GOC:mah, PR:000000017] synonym: "IFNG binding" EXACT [GOC:mah] synonym: "type II interferon binding" BROAD [PMID:15546383, PR:000024990] is_a: GO:0019961 ! interferon binding [Term] id: GO:0019966 name: interleukin-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-1." [GOC:jl, ISBN:0198506732] synonym: "IL-1 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019969 name: interleukin-10 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-10." [GOC:jl] synonym: "IL-10 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019970 name: interleukin-11 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-11." [GOC:jl] synonym: "IL-11 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019972 name: interleukin-12 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-12." [GOC:jl] synonym: "IL-12 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019973 name: interleukin-13 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-13." [GOC:jl] synonym: "IL-13 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019974 name: interleukin-14 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-14." [GOC:jl] synonym: "IL-14 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019975 name: interleukin-17 binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the interleukin-17 family of cytokines." [GOC:add, GOC:jl] synonym: "IL-17 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019976 name: interleukin-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-2." [GOC:jl] synonym: "IL-2 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019977 name: interleukin-21 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-21." [GOC:jl] synonym: "IL-21 binding" EXACT [] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019978 name: interleukin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-3." [GOC:jl] synonym: "IL-3 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019979 name: interleukin-4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-4." [GOC:jl] synonym: "IL-4 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019980 name: interleukin-5 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-5." [GOC:jl] synonym: "IL-5 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019981 name: interleukin-6 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-6." [GOC:jl] synonym: "IL-6 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019982 name: interleukin-7 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-7." [GOC:jl] synonym: "IL-7 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019983 name: interleukin-9 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-9." [GOC:jl] synonym: "IL-9 binding" EXACT [] is_a: GO:0019838 ! growth factor binding is_a: GO:0019955 ! cytokine binding [Term] id: GO:0019985 name: translesion synthesis namespace: biological_process def: "The replication of damaged DNA by synthesis across a lesion in the template strand; a specialized DNA polymerase or replication complex inserts a defined nucleotide across from the lesion which allows DNA synthesis to continue beyond the lesion. This process can be mutagenic depending on the damaged nucleotide and the inserted nucleotide." [GOC:elh, GOC:vw, PMID:10535901] synonym: "bypass DNA synthesis" EXACT [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0006301 ! postreplication repair [Term] id: GO:0019987 name: obsolete negative regulation of anti-apoptosis namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of anti-apoptosis." [GOC:go_curators, GOC:mtg_apoptosis] comment: This term was made obsolete because it was ill-defined. synonym: "down regulation of anti-apoptosis" EXACT [] synonym: "down-regulation of anti-apoptosis" EXACT [] synonym: "downregulation of anti-apoptosis" EXACT [] synonym: "inhibition of anti-apoptosis" NARROW [] synonym: "negative regulation of anti-apoptosis" EXACT [] is_obsolete: true [Term] id: GO:0019988 name: charged-tRNA amino acid modification namespace: biological_process alt_id: GO:0030630 def: "The covalent alteration of an amino acid charged on a tRNA before it is incorporated into a protein, as in N-formylmethionine, selenocysteine or pyrrolysine." [GOC:jsg] synonym: "charged tRNA amino acid modification" EXACT [] synonym: "charged tRNA modification" EXACT [] synonym: "charged-tRNA modification" RELATED [] synonym: "pre-translational amino acid modification" EXACT [] synonym: "pre-translational protein modification" EXACT [] synonym: "pretranslation protein modification" EXACT [] synonym: "pretranslational amino acid modification" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0019990 name: pteridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732] synonym: "pteridine breakdown" EXACT [] synonym: "pteridine catabolism" EXACT [] synonym: "pteridine degradation" EXACT [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042560 ! pteridine-containing compound catabolic process [Term] id: GO:0019991 name: septate junction assembly namespace: biological_process def: "The assembly of a septate junction, an intercellular junction found in invertebrate epithelia that is characterized by a ladder like appearance in electron micrographs and thought to provide structural strength and to provide a barrier to diffusion of solutes through the intercellular space." [GOC:ai, PMID:5272312] is_a: GO:0120192 ! tight junction assembly relationship: part_of GO:0043297 ! apical junction assembly [Term] id: GO:0019992 name: diacylglycerol binding namespace: molecular_function def: "Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids." [GOC:ma] is_a: GO:0008289 ! lipid binding [Term] id: GO:0020002 name: host cell plasma membrane namespace: cellular_component def: "The plasma membrane surrounding a host cell." [GOC:mb] is_a: GO:0033644 ! host cell membrane [Term] id: GO:0020003 name: symbiont-containing vacuole namespace: cellular_component def: "Membrane-bounded vacuole within a host cell in which a symbiont organism resides. The vacuole membrane is derived from both the host and symbiont." [GOC:jl, GOC:mb] comment: Note that this term does not have a relationship to 'vacuole ; GO:0005773' because it does not fit the definition of a vacuole; the parasitophorous vacuole was so named because it resembles a vacuole in the microscope. synonym: "bacterium-containing vacuole" NARROW [PMID:22042847] synonym: "parasitophorous vacuole" EXACT [] synonym: "pathogen-occupied vacuole" NARROW [PMID:24034612] synonym: "Salmonella-containing vacuole" NARROW [PMID:10449405, PMID:15121880] synonym: "SCV" EXACT [PMID:10449405, PMID:15121880] is_a: GO:0033655 ! host cell cytoplasm part is_a: GO:0065010 ! extracellular membrane-bounded organelle [Term] id: GO:0020004 name: symbiont-containing vacuolar space namespace: cellular_component def: "The space between a symbiont plasma membrane and the symbiont-containing vacuole membrane." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar space" EXACT [] synonym: "symbiont-containing vacuole space" RELATED [] is_a: GO:0033643 ! host cell part is_a: GO:0044421 ! extracellular region part is_a: GO:0044422 ! organelle part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020005 name: symbiont-containing vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a symbiont-containing vacuole, derived from both the host and symbiont." [GOC:jl, GOC:mb] synonym: "parasitophorous vacuolar membrane" EXACT [] is_a: GO:0033643 ! host cell part is_a: GO:0044421 ! extracellular region part is_a: GO:0044422 ! organelle part relationship: part_of GO:0020003 ! symbiont-containing vacuole [Term] id: GO:0020006 name: symbiont-containing vacuolar membrane network namespace: cellular_component def: "Tubular network of extensions from the symbiont-containing vacuole membrane that protrude into the host cytoplasm." [GOC:jl, PMID:3528173] synonym: "parasitophorous vacuolar membrane network" EXACT [] synonym: "symbiont-containing vacuole membrane network" EXACT [] synonym: "tubulovesicular network" NARROW [] is_a: GO:0033643 ! host cell part is_a: GO:0044421 ! extracellular region part is_a: GO:0044422 ! organelle part relationship: part_of GO:0020005 ! symbiont-containing vacuole membrane [Term] id: GO:0020007 name: apical complex namespace: cellular_component def: "A group of cytoskeletal structures and associated membrane-bounded organelles found at the anterior end of adult obligate intracellular protozoan parasites in the phylum Apicomplexa. The apical complex is involved in attachment to and penetration of the host cell, and in parasite proliferation." [GOC:giardia, GOC:mb, PMID:16518471] is_a: GO:0044464 ! cell part relationship: part_of GO:0045177 ! apical part of cell [Term] id: GO:0020008 name: rhoptry namespace: cellular_component def: "A large, club-shaped secretory organelle that forms part of the apical complex of an apicomplexan parasite, and consists of a bulbous body and a narrow electron-dense neck that extends through the conoid at the apical tip of the parasite. The rhoptry necks serve as ducts through which the contents of the rhoptries are secreted after attachment to the host has been completed and at the commencement of invasion. Rhoptry proteins function in the biogenesis and host organellar association of the parasitophorous vacuole." [ISBN:0521664470, PMID:11801218, PMID:16002398] synonym: "paired organelles" RELATED [] synonym: "toxoneme" RELATED [] xref: Wikipedia:Rhoptry is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020009 name: microneme namespace: cellular_component def: "A small, elongated secretory organelle that forms part of the apical complex, located along the main axis of an apicomplexan parasite cell within the extreme apical region and at the periphery under the inner membrane complex. Of the specialized secretory compartments identified in apicomplexans, micronemes discharge their contents first, during initial contact of the parasite's apical pole with the host cell surface. Micronemal proteins function during parasite attachment and penetration into the target cell." [ISBN:0521664470, PMID:11801218] synonym: "sarconeme" RELATED [] xref: Wikipedia:Microneme is_a: GO:0043231 ! intracellular membrane-bounded organelle relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020010 name: conoid namespace: cellular_component def: "A spiral cytoskeletal structure located at the apical end of the apical complex in some apicomplexan parasites. Fibers form a left-handed spiral, and are comprised of tubulin protofilaments organized in a ribbon-like structure that differs from the conventional tubular structure characteristic of microtubules." [GOC:expert_dr, PMID:11901169, PMID:16518471] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020011 name: apicoplast namespace: cellular_component def: "The plastid organelle found in apicomplexans." [ISBN:0521664470] xref: Wikipedia:Apicoplast is_a: GO:0009536 ! plastid [Term] id: GO:0020012 name: evasion or tolerance of host immune response namespace: biological_process def: "Any process, either active or passive, by which an organism avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "immune evasion" BROAD [] is_a: GO:0030682 ! evasion or tolerance of host defense response is_a: GO:0051805 ! evasion or tolerance of immune response of other organism involved in symbiotic interaction is_a: GO:0052572 ! response to host immune response [Term] id: GO:0020013 name: modulation by symbiont of host erythrocyte aggregation namespace: biological_process def: "Any process in which a symbiont organism modulates the frequency, rate or extent of erythrocyte aggregation in its host organism, e.g. the binding of parasite-infected erythrocytes to uninfected erythrocytes." [GOC:add, GOC:dgh, GOC:mb, GOC:pr, PMID:19467172, PMID:21305024] comment: Please note that this term does not refer to the in vitro assay called erythrocyte rosetting. synonym: "rosetting" EXACT [] xref: Wikipedia:Rosetting is_a: GO:0034118 ! regulation of erythrocyte aggregation is_a: GO:0044068 ! modulation by symbiont of host cellular process [Term] id: GO:0020014 name: schizogony namespace: biological_process def: "Cell division by multiple fission in which nuclei and other organelles in the parent cell divide repeatedly and move to the cell periphery before internal membranes develop around them, producing a large number of daughter cells simultaneously." [GOC:mb] xref: Wikipedia:Protozoal_merogony is_a: GO:0051301 ! cell division [Term] id: GO:0020015 name: glycosome namespace: cellular_component def: "A membrane-bounded organelle found in organisms from the order Kinetoplastida that houses the enzymes of glycolysis." [GOC:mb] subset: goslim_pir xref: Wikipedia:Glycosome is_a: GO:0005777 ! peroxisome [Term] id: GO:0020016 name: ciliary pocket namespace: cellular_component def: "Invagination of the plasma membrane from which a cilium (also called flagellum) protrudes." [GOC:cilia, GOC:mb] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. synonym: "cilial pocket" EXACT [] synonym: "cilium pocket" EXACT [] synonym: "flagellar pocket" EXACT [] is_a: GO:0044441 ! ciliary part [Term] id: GO:0020018 name: ciliary pocket membrane namespace: cellular_component def: "That part of the plasma membrane found in the ciliary pocket (also called flagellar pocket)." [GOC:cilia, GOC:mb] comment: Note that cilia and eukaryotic flagella are deemed to be equivalent. In this case community usage is mostly 'flagellar', but the primary term name reflects the cilium parentage. synonym: "cilial pocket membrane" EXACT [] synonym: "cilium pocket membrane" EXACT [] synonym: "flagellar pocket membrane" EXACT [] is_a: GO:0060170 ! ciliary membrane relationship: part_of GO:0020016 ! ciliary pocket [Term] id: GO:0020020 name: food vacuole namespace: cellular_component alt_id: GO:0005772 def: "Vacuole within a parasite used for digestion of the host cell cytoplasm. An example of this component is found in the Apicomplexa." [GOC:mb] synonym: "digestive vacuole" EXACT [] is_a: GO:0032010 ! phagolysosome [Term] id: GO:0020021 name: immortalization of host cell namespace: biological_process def: "The modification of a host cell into an immortal cell line as a consequence of infection. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell immortalization" EXACT [] synonym: "host cell transformation" EXACT [] synonym: "transformation of host cell" EXACT [] is_a: GO:0051701 ! interaction with host [Term] id: GO:0020022 name: acidocalcisome namespace: cellular_component def: "An electron-dense acidic membrane-bounded organelle which contains a matrix of pyrophosphate and polyphosphates with bound calcium and other cations." [GOC:mb] subset: goslim_pir synonym: "metachromatic granule" EXACT [PMID:15738951] synonym: "polyphosphate vacuole" RELATED [PMID:15738951] synonym: "volutin granule" EXACT [PMID:15738951] is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0020023 name: kinetoplast namespace: cellular_component def: "A sub-structure within the large single mitochondrion of kinetoplastid parasites and which is closely associated with the flagellar pocket and basal body of the flagellum." [GOC:mb] xref: Wikipedia:Kinetoplast is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0020025 name: subpellicular microtubule namespace: cellular_component def: "Singlet microtubule that lie underneath the inner membrane pellicle complex and emanate from the basal ring of the conoid." [GOC:mb, PMID:24800253] is_a: GO:0005874 ! microtubule relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020026 name: merozoite dense granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix found throughout the merozoite life cycle stage of apicomplexan parasites; contains proteins destined to be secreted into the parasitophorous vacuole following parasite invasion of a host cell." [GOC:mb, GOC:mtg_sensu] synonym: "dense body" RELATED [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0020027 name: hemoglobin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemoglobin, including its uptake and utilization." [GOC:go_curators, GOC:jl] synonym: "haemoglobin metabolic process" EXACT [] synonym: "haemoglobin metabolism" EXACT [] synonym: "hemoglobin metabolism" EXACT [] is_a: GO:0019538 ! protein metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0020028 name: endocytic hemoglobin import namespace: biological_process def: "The directed movement into a tissue or a cell or organelle of externally available hemoglobin by receptor-mediated endocytosis." [GOC:mb] synonym: "haemoglobin uptake" EXACT [] synonym: "hemoglobin uptake" EXACT [] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0015886 ! heme transport is_a: GO:0017038 ! protein import is_a: GO:0033212 ! iron import into cell is_a: GO:0072594 ! establishment of protein localization to organelle [Term] id: GO:0020030 name: infected host cell surface knob namespace: cellular_component def: "Protrusion that develops in the plasma membrane of a parasitized erythrocyte. An example of this component is found in Plasmodium species." [GOC:mb] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020031 name: polar ring of apical complex namespace: cellular_component def: "An electron dense ring at the most anterior position of the apical complex, from which the conoid fibers originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mb, PMID:16518471] synonym: "anterior polar ring of apical complex" EXACT [] synonym: "upper polar ring of apical complex" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020032 name: basal ring of apical complex namespace: cellular_component def: "An electron dense ring at the most posterior position of the apical complex, from which the subpellicular microtubules originate; formed during an invasive life cycle stage of an apicomplexan parasite." [GOC:mah, PMID:16518471] synonym: "lower polar ring of apical complex" EXACT [] synonym: "posterior polar ring of apical complex" EXACT [] synonym: "preconoidal ring of apical complex" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0020007 ! apical complex [Term] id: GO:0020033 name: antigenic variation namespace: biological_process alt_id: GO:0020034 def: "Any process involved in the biological strategy of changing antigenic determinants on the surface that are exposed to another organism's immune system." [GOC:mb] synonym: "surface antigen variation" NARROW [] xref: Wikipedia:Antigenic_variation is_a: GO:0051809 ! passive evasion of immune response of other organism involved in symbiotic interaction [Term] id: GO:0020035 name: cytoadherence to microvasculature, mediated by symbiont protein namespace: biological_process def: "The adherence of symbiont-infected erythrocytes to microvascular endothelium via symbiont proteins embedded in the membrane of the erythrocyte." [GOC:mb] synonym: "cytoadherence to microvasculature, mediated by parasite protein" NARROW [] synonym: "cytoadherence to microvasculature, mediated by symbiont protein" BROAD [] synonym: "parasite-protein-mediated cytoadherence to microvasculature" EXACT [] synonym: "symbiont-protein-mediated cytoadherence to microvasculature" BROAD [] is_a: GO:0044406 ! adhesion of symbiont to host [Term] id: GO:0020036 name: Maurer's cleft namespace: cellular_component def: "A disk-like structure that appears at the periphery of a red blood cell infected by an apicomplexan parasite, characterized by a translucent lumen and an electron-dense coat of variable thickness; often appears to be tethered to the host cell membrane by fibrous connections with the erythrocyte cytoskeleton." [PMID:16705161] synonym: "Maurers cleft" EXACT [] is_a: GO:0033655 ! host cell cytoplasm part [Term] id: GO:0020037 name: heme binding namespace: molecular_function def: "Interacting selectively and non-covalently with heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring." [CHEBI:30413, GOC:ai] synonym: "haem binding" EXACT [] is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0020038 name: subpellicular network namespace: cellular_component def: "A mechanically stable cytoskeletal structure associated with the cytoplasmic face of the pellicle and surrounding the microtubule-based cytoskeleton." [PMID:11420112] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0020039 ! pellicle [Term] id: GO:0020039 name: pellicle namespace: cellular_component def: "The structure enclosing certain parasite cells such as certain apicomplexa and Euglenozoa; consists of the cell membrane with its associated infrastructure of microtubules, microfilaments and other organelles." [GOC:mah, GOC:mb] is_a: GO:0044464 ! cell part [Term] id: GO:0021501 name: prechordal plate formation namespace: biological_process def: "The formation of the prechordal plate. The prechordal plate is a thickening of the endoderm at the cranial end of the primitive streak formed by the involution of Spemann's organizer cells. The prechordal plate and the notochord induce the formation of the neural plate from the overlying ectodermal cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021502 name: neural fold elevation formation namespace: biological_process def: "The process in which the lateral borders of the neural plate begin to migrate upwards to form the neural folds, caused by the proliferation of the underlying mesoderm." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021503 name: neural fold bending namespace: biological_process def: "The morphogenesis of the neural fold elevations that results in the movement of the tips of the elevations towards each other in order to fuse." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001842 ! neural fold formation [Term] id: GO:0021504 name: neural fold hinge point formation namespace: biological_process def: "The formation of the median and lateral hinge points in the neural folds. These are created by apical constriction and basal expansion of the underlying neural cells. The median hinge point extends for the entire length of the neural tube, and the lateral hinge points do not form in the spinal cord region of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. synonym: "neural fold furrowing" NARROW [GOC:cls] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021505 name: neural fold folding namespace: biological_process def: "The process of folding the neuroepithelium around the medial hinge point to create the neural elevations, and around the lateral hinge points to produce convergence of the folds." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0021503 ! neural fold bending [Term] id: GO:0021506 name: anterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the rostral opening of the neural tube. The anterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021507 name: posterior neuropore closure namespace: biological_process def: "The joining together of the neural folds of the caudal opening of the neural tube. The posterior neuropore appears before the process of neural tube closure is complete." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060608 ! cell-cell adhesion involved in neural tube closure relationship: part_of GO:0021995 ! neuropore closure [Term] id: GO:0021508 name: floor plate formation namespace: biological_process def: "The formation of a ventral region of glial cells in the neural tube that provides inductive signals for the specification of neuronal cell types. The floor plate is evident at the ventral midline by the neural fold stage." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007418 ! ventral midline development relationship: part_of GO:0033505 ! floor plate morphogenesis [Term] id: GO:0021509 name: roof plate formation namespace: biological_process def: "The formation of a single row of glia at the dorsal midline of the developing neural tube. This region provides inductive signals for the specification of neuronal cell types and of the specification of neural crest cells. The cells comprising the roof plate are the precursors to radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001841 ! neural tube formation [Term] id: GO:0021510 name: spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048513 ! animal organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021511 name: spinal cord patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth and establishes the non-random spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021512 name: spinal cord anterior/posterior patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord anterior-posterior patterning" EXACT [] synonym: "spinal cord rostrocaudal patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021513 name: spinal cord dorsal/ventral patterning namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random dorsal-ventral spatial arrangement of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal-ventral patterning" EXACT [] synonym: "spinal cord dorsoventral patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021511 ! spinal cord patterning [Term] id: GO:0021514 name: ventral spinal cord interneuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of ventral spinal cord interneurons. Ventral spinal cord interneurons are cells located in the ventral portion of the spinal cord that transmit signals between sensory and motor neurons and are required for reflexive responses. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021515 name: cell differentiation in spinal cord namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021516 name: dorsal spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal region of the spinal cord over time, from its formation to the mature structure. The dorsal region of the mature spinal cord contains neurons that process and relay sensory input." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11179871] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021517 name: ventral spinal cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral region of the spinal cord over time, from its formation to the mature structure. The neurons of the ventral region of the mature spinal cord participate in motor output." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021518 name: spinal cord commissural neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a commissural neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021528 ! commissural neuron differentiation in spinal cord [Term] id: GO:0021519 name: spinal cord association neuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an association neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021527 ! spinal cord association neuron differentiation [Term] id: GO:0021520 name: spinal cord motor neuron cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification relationship: part_of GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021521 name: ventral spinal cord interneuron specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a ventral spinal cord interneuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048665 ! neuron fate specification is_a: GO:0060573 ! cell fate specification involved in pattern specification relationship: part_of GO:0060579 ! ventral spinal cord interneuron fate commitment [Term] id: GO:0021522 name: spinal cord motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of motor neurons. Motor neurons innervate an effector (muscle or glandular) tissue and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021517 ! ventral spinal cord development [Term] id: GO:0021523 name: somatic motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of somatic motor neurons. Somatic motor neurons innervate skeletal muscle targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021524 name: visceral motor neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of visceral motor neurons. Visceral motor neurons innervate glandular targets and are responsible for transmission of motor impulses from the brain to the periphery. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation [Term] id: GO:0021525 name: lateral motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of lateral motor column neurons. Lateral motor column neurons are generated only on limb levels and send axons into the limb mesenchyme. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021522 ! spinal cord motor neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021526 name: medial motor column neuron differentiation namespace: biological_process def: "The process in which differentiating motor neurons in the neural tube acquire the specialized structural and/or functional features of medial motor column neurons. Medial motor column neurons are generated at all rostrocaudal levels and send axons to the axial muscles (medial group) and to the body wall muscles (lateral group). Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021527 name: spinal cord association neuron differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of association neurons. Association neurons are cells located in the dorsal portion of the spinal cord that integrate sensory input. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "spinal cord dorsal interneuron differentiation" EXACT [GOC:dph] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021516 ! dorsal spinal cord development [Term] id: GO:0021528 name: commissural neuron differentiation in spinal cord namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of commissural neurons. Commissural neurons in both vertebrates and invertebrates transfer information from one side of their bodies to the other through the midline. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021529 name: spinal cord oligodendrocyte cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of oligodendrocytes. Oligodendrocytes are non-neuronal cells. The primary function of oligodendrocytes is the myelination of nerve axons in the central nervous system. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021530 name: spinal cord oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021778 ! oligodendrocyte cell fate specification relationship: part_of GO:0021529 ! spinal cord oligodendrocyte cell differentiation [Term] id: GO:0021531 name: spinal cord radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the ventral neural tube acquire specialized structural and/or functional features of radial glial cells. Radial cell precursors differentiate into both neuronal cell types and mature radial glial cells. Mature radial glial cells regulate the axon growth and pathfinding processes that occur during white matter patterning of the developing spinal cord. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16185248] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in spinal cord" EXACT [GOC:curators] is_a: GO:0021515 ! cell differentiation in spinal cord is_a: GO:0060019 ! radial glial cell differentiation [Term] id: GO:0021532 name: neural tube patterning namespace: biological_process def: "The regionalization process that regulates the coordinated growth that establishes the non-random spatial arrangement of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0021533 name: cell differentiation in hindbrain namespace: biological_process def: "The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the mature cells of the hindbrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021534 name: cell proliferation in hindbrain namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021535 name: cell migration in hindbrain namespace: biological_process def: "The orderly movement of a cell that will reside in the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021536 name: diencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the diencephalon over time, from its formation to the mature structure. The diencephalon is the paired caudal parts of the prosencephalon from which the thalamus, hypothalamus, epithalamus and subthalamus are derived; these regions regulate autonomic, visceral and endocrine function, and process information directed to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021537 name: telencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the telencephalon over time, from its formation to the mature structure. The telencephalon is the paired anteriolateral division of the prosencephalon plus the lamina terminalis from which the olfactory lobes, cerebral cortex, and subcortical nuclei are derived." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cerebrum development" EXACT [GOC:sl, PMID:22331407] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021538 name: epithalamus development namespace: biological_process def: "The progression of the epithalamus over time from its initial formation until its mature state. The epithalamus is the small dorsomedial area of the thalamus including the habenular nuclei and associated fiber bundles, the pineal body, and the epithelial roof of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021539 name: subthalamus development namespace: biological_process def: "The process whose specific outcome is the progression of the subthalamus over time, from its formation to the mature structure. The subthalamus is the anterior part of the diencephalon that lies between the thalamus, hypothalamus, and tegmentum of the mesencephalon, including subthalamic nucleus, zona incerta, the fields of Forel, and the nucleus of ansa lenticularis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "ventral thalamus development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021540 name: corpus callosum morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the corpus callosum are generated and organized. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provides communications between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0022038 ! corpus callosum development [Term] id: GO:0021541 name: ammon gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the ammon gyrus over time, from its formation to the mature structure. The ammon gyrus, often subdivided into the CA1 and CA3 regions, is one of the two interlocking gyri of the hippocampus that is rich in large pyramidal neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "Ammon's horn development" RELATED [GOC:cls] synonym: "cornu ammonis development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021542 name: dentate gyrus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate gyrus over time, from its formation to the mature structure. The dentate gyrus is one of two interlocking gyri of the hippocampus. It contains granule cells, which project to the pyramidal cells and interneurons of the CA3 region of the ammon gyrus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021766 ! hippocampus development [Term] id: GO:0021543 name: pallium development namespace: biological_process def: "The process whose specific outcome is the progression of the pallium over time, from its formation to the mature structure. The pallium is the roof region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021544 name: subpallium development namespace: biological_process def: "The process whose specific outcome is the progression of the subpallium over time, from its formation to the mature structure. The subpallium is the base region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021545 name: cranial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the cranial nerves over time, from its formation to the mature structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021675 ! nerve development [Term] id: GO:0021546 name: rhombomere development namespace: biological_process def: "The process whose specific outcome is the progression of the rhombomere over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021547 name: midbrain-hindbrain boundary initiation namespace: biological_process def: "The regionalization process that gives rise to the midbrain-hindbrain boundary. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus biosynthesis" RELATED [GOC:cls] synonym: "isthmus formation" RELATED [GOC:cls] synonym: "MHB biosynthesis" EXACT [GOC:cls] synonym: "MHB formation" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary biosynthesis" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary formation" EXACT [GOC:cls] is_a: GO:0003002 ! regionalization is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021548 name: pons development namespace: biological_process def: "The process whose specific outcome is the progression of the pons over time, from its formation to the mature structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021549 name: cerebellum development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0022037 ! metencephalon development [Term] id: GO:0021550 name: medulla oblongata development namespace: biological_process def: "The process whose specific outcome is the progression of the medulla oblongata over time, from its formation to the mature structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla development" RELATED [GOC:cls] synonym: "myelencephalon development" RELATED [GOC:cls] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021551 name: central nervous system morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the central nervous system is generated and organized. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021552 name: midbrain-hindbrain boundary structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the midbrain-hindbrain boundary structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus structural organization" RELATED [GOC:cls] synonym: "MHB structural organization" EXACT [GOC:cls] synonym: "midbrain-hindbrain boundary structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021555 ! midbrain-hindbrain boundary morphogenesis [Term] id: GO:0021553 name: olfactory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the olfactory nerve over time, from its formation to the mature structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN 1 development" RELATED [GOC:cls] synonym: "cranial nerve 1 development" EXACT [GOC:cls] synonym: "cranial nerve I development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021554 name: optic nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the optic nerve over time, from its formation to the mature structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II development" RELATED [GOC:cls] synonym: "cranial nerve 2 development" EXACT [GOC:cls] synonym: "cranial nerve II development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021555 name: midbrain-hindbrain boundary morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the midbrain-hindbrain boundary is generated and organized. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus morphogenesis" EXACT [GOC:cls] synonym: "MHB morphogenesis" EXACT [GOC:cls] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021556 name: central nervous system formation namespace: biological_process def: "The process that gives rise to the central nervous system. This process pertains to the initial formation of a structure from unspecified parts. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021557 name: oculomotor nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the oculomotor nerve over time, from its formation to the mature structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III development" RELATED [GOC:cls] synonym: "cranial nerve 3 development" EXACT [GOC:cls] synonym: "cranial nerve III development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021558 name: trochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trochlear nerve over time, from its formation to the mature structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV development" RELATED [GOC:cls] synonym: "cranial nerve 4 development" EXACT [GOC:cls] synonym: "cranial nerve IV development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021559 name: trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal nerve over time, from its formation to the mature structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V development" RELATED [GOC:cls] synonym: "cranial nerve 5 development" EXACT [GOC:cls] synonym: "cranial nerve V development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021560 name: abducens nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nerve over time, from its formation to the mature structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [GOC:cls] synonym: "cranial nerve 6 development" EXACT [GOC:cls] synonym: "cranial nerve VI development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021561 name: facial nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nerve over time, from its formation to the mature structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives off nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII development" RELATED [GOC:cls] synonym: "cranial nerve 7 development" EXACT [GOC:cls] synonym: "cranial nerve VII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021562 name: vestibulocochlear nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibulocochlear nerve over time, from its formation to the mature structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "acoustic nerve development" EXACT [PMID:11533729] synonym: "CN VIII development" EXACT [GOC:cls] synonym: "cranial nerve 8 development" EXACT [GOC:cls] synonym: "cranial nerve VIII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021563 name: glossopharyngeal nerve development namespace: biological_process def: "Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX development" RELATED [GOC:cls] synonym: "cranial nerve 9 development" EXACT [GOC:cls] synonym: "cranial nerve IX development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021564 name: vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the vagus nerve over time, from its formation to the mature structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X development" RELATED [GOC:cls] synonym: "cranial nerve 10 development" RELATED [GOC:cls] synonym: "cranial nerve X development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development relationship: part_of GO:0021783 ! preganglionic parasympathetic fiber development [Term] id: GO:0021565 name: accessory nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the accessory nerve over time, from its formation to the mature structure. In mice, the spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI development" RELATED [GOC:cls] synonym: "cranial nerve 11 development" RELATED [GOC:cls] synonym: "cranial nerve XI development" EXACT [GOC:cls] synonym: "spinal accessory nerve development" EXACT [PMID:11533729] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021566 name: hypoglossal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nerve over time, from its formation to the mature structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII development" RELATED [GOC:cls] synonym: "cranial nerve 12 development" RELATED [GOC:cls] synonym: "cranial nerve XII development" EXACT [GOC:cls] is_a: GO:0021545 ! cranial nerve development [Term] id: GO:0021567 name: rhombomere 1 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 1 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021568 name: rhombomere 2 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 2 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021569 name: rhombomere 3 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 3 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021570 name: rhombomere 4 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 4 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021571 name: rhombomere 5 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 5 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021572 name: rhombomere 6 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 6 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021573 name: rhombomere 7 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 7 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021574 name: rhombomere 8 development namespace: biological_process def: "The process whose specific outcome is the progression of rhombomere 8 over time, from its formation to the mature structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021546 ! rhombomere development [Term] id: GO:0021575 name: hindbrain morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hindbrain is generated and organized. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "rhombencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021576 name: hindbrain formation namespace: biological_process def: "The process that gives rise to the hindbrain. This process pertains to the initial formation of a structure from unspecified parts. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021577 name: hindbrain structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hindbrain. This process pertains to the physical shaping of a rudimentary structure. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "hindbrain structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021578 name: hindbrain maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hindbrain to attain its fully functional state. The hindbrain is the region consisting of the medulla, pons and cerebellum. Areas of the hindbrain control motor and autonomic functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021626 ! central nervous system maturation relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021579 name: medulla oblongata morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the medulla oblongata is generated and organized. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla morphogenesis" RELATED [] synonym: "myelencephalon morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021580 name: medulla oblongata formation namespace: biological_process def: "The process that gives rise to the medulla oblongata. This process pertains to the initial formation of a structure from unspecified parts. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla biosynthesis" RELATED [] synonym: "medulla formation" RELATED [] synonym: "myelencephalon biosynthesis" RELATED [] synonym: "myelencephalon formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021581 name: medulla oblongata structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the medulla oblongata. This process pertains to the physical shaping of a rudimentary structure. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla oblongata structural organisation" EXACT [GOC:mah] synonym: "medulla structural maturation" RELATED [] synonym: "myelencephalon structural maturation" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021579 ! medulla oblongata morphogenesis [Term] id: GO:0021582 name: medulla oblongata maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the medulla oblongata to attain its fully functional state. The medulla oblongata lies directly above the spinal cord and controls vital autonomic functions such as digestion, breathing and the control of heart rate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "medulla maturation" RELATED [] synonym: "myelencephalon maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021550 ! medulla oblongata development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021583 name: pons morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the pons is generated and organized. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021584 name: pons formation namespace: biological_process def: "The process that gives rise to the pons. This process pertains to the initial formation of a structure from unspecified parts. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021585 name: pons structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the pons. This process pertains to the physical shaping of a rudimentary structure. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "pons structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021583 ! pons morphogenesis [Term] id: GO:0021586 name: pons maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the pons to attain its fully functional state. The pons lies above the medulla and next to the cerebellum. The pons conveys information about movement from the cerebral hemisphere to the cerebellum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021587 name: cerebellum morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellum is generated and organized. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021575 ! hindbrain morphogenesis [Term] id: GO:0021588 name: cerebellum formation namespace: biological_process def: "The process that gives rise to the cerebellum. This process pertains to the initial formation of a structure from unspecified parts. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021576 ! hindbrain formation relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021589 name: cerebellum structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellum. This process pertains to the physical shaping of a rudimentary structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellum structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021577 ! hindbrain structural organization relationship: part_of GO:0021587 ! cerebellum morphogenesis [Term] id: GO:0021590 name: cerebellum maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellum to attain its fully functional state. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. The cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021549 ! cerebellum development relationship: part_of GO:0021578 ! hindbrain maturation [Term] id: GO:0021591 name: ventricular system development namespace: biological_process def: "The process whose specific outcome is the progression of the brain ventricular system over time, from its formation to the mature structure. The brain ventricular system consists of four communicating cavities within the brain that are continuous with the central canal of the spinal cord. These cavities include two lateral ventricles, the third ventricle and the fourth ventricle. Cerebrospinal fluid fills the ventricles and is produced by the choroid plexus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021592 name: fourth ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the fourth ventricle over time, from its formation to the mature structure. The fourth ventricle is an irregularly shaped cavity in the rhombencephalon, between the medulla oblongata, the pons, and the isthmus in front, and the cerebellum behind. It is continuous with the central canal of the cord below and with the cerebral aqueduct above, and through its lateral and median apertures it communicates with the subarachnoid space." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0021593 name: rhombomere morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the rhombomere is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0021594 name: rhombomere formation namespace: biological_process def: "The process that gives rise to the rhombomere. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021595 name: rhombomere structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the rhombomere structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "rhombomere structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021593 ! rhombomere morphogenesis [Term] id: GO:0021597 name: central nervous system structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the central nervous system structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. synonym: "central nervous system structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021551 ! central nervous system morphogenesis [Term] id: GO:0021598 name: abducens nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the abducens nerve is generated and organized. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI development" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021599 name: abducens nerve formation namespace: biological_process def: "The process that gives rise to the abducens nerve. This process pertains to the initial formation of a structure from unspecified parts. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI biosynthesis" RELATED [] synonym: "CN VI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021600 name: abducens nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the abducens nerve. This process pertains to the physical shaping of a rudimentary structure. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "abducens nerve structural organisation" EXACT [GOC:mah] synonym: "CN VI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021598 ! abducens nerve morphogenesis [Term] id: GO:0021601 name: abducens nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the abducens nerve to attain its fully functional state. The motor function of the abducens nerve is to contract the lateral rectus which results in abduction of the eye." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VI maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021560 ! abducens nerve development [Term] id: GO:0021602 name: cranial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021603 name: cranial nerve formation namespace: biological_process def: "The process that gives rise to the cranial nerves. This process pertains to the initial formation of a structure from unspecified parts. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021604 name: cranial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cranial nerves. This process pertains to the physical shaping of a rudimentary structure. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cranial nerve structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021602 ! cranial nerve morphogenesis [Term] id: GO:0021605 name: cranial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a cranial nerve to attain its fully functional state. The cranial nerves are composed of twelve pairs of nerves that emanate from the nervous tissue of the hindbrain. These nerves are sensory, motor, or mixed in nature, and provide the motor and general sensory innervation of the head, neck and viscera. They mediate vision, hearing, olfaction and taste and carry the parasympathetic innervation of the autonomic ganglia that control visceral functions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0021682 ! nerve maturation relationship: part_of GO:0021545 ! cranial nerve development [Term] id: GO:0021606 name: accessory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the accessory nerve to attain its fully functional state. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI maturation" RELATED [] synonym: "spinal accessory nerve maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021607 name: accessory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the accessory nerve is generated and organized. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021565 ! accessory nerve development [Term] id: GO:0021608 name: accessory nerve formation namespace: biological_process def: "The process that gives rise to the accessory nerve. This process pertains to the initial formation of a structure from unspecified parts. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XI biosynthesis" RELATED [] synonym: "CN XI formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021609 name: accessory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the accessory nerve This process pertains to the physical shaping of a rudimentary structure. The spinal branch of this motor nerve innervates the trapezius and the sternocleidomastoid muscles. The cranial branch joins the vagus nerve and innervates the same targets as the vagus nerve." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "accessory nerve structural organisation" EXACT [GOC:mah] synonym: "CN XI structural organization" RELATED [] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021607 ! accessory nerve morphogenesis [Term] id: GO:0021610 name: facial nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the facial nerve is generated and organized. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021611 name: facial nerve formation namespace: biological_process def: "The process that gives rise to the facial nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII biosynthesis" RELATED [] synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021612 name: facial nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the facial nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] synonym: "facial nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021610 ! facial nerve morphogenesis [Term] id: GO:0021613 name: facial nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the facial nerve to attain its fully functional state. This sensory and motor nerve supplies the muscles of facial expression and the expression and taste at the anterior two-thirds of the tongue. The principal branches are the superficial opthalmic, buccal, palatine and hyomandibular. The main trunk synapses within pterygopalatine ganglion in the parotid gland and this ganglion then gives of nerve branches which supply the lacrimal gland and the mucous secreting glands of the nasal and oral cavities." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021561 ! facial nerve development [Term] id: GO:0021614 name: glossopharyngeal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the glossopharyngeal nerve to attain its fully functional state. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021615 name: glossopharyngeal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the glossopharyngeal nerve is generated and organized. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021563 ! glossopharyngeal nerve development [Term] id: GO:0021616 name: glossopharyngeal nerve formation namespace: biological_process def: "The process that gives rise to the glossopharyngeal nerve. This process pertains to the initial formation of a structure from unspecified parts. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX biosynthesis" RELATED [] synonym: "CN IX formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021617 name: glossopharyngeal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the glossopharyngeal nerve. This process pertains to the physical shaping of a rudimentary structure. Various sensory and motor branches of the glossopharyngeal nerve supply nerve connections to the pharynx and back of the tongue. The branchial motor component contains motor fibers that innervate muscles that elevate the pharynx and larynx, and the tympanic branch supplies parasympathetic fibers to the otic ganglion." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IX structural organization" RELATED [] synonym: "glossopharyngeal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021615 ! glossopharyngeal nerve morphogenesis [Term] id: GO:0021618 name: hypoglossal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the hypoglossal nerve is generated and organized. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021619 name: hypoglossal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the hypoglossal nerve to attain its fully functional state. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021566 ! hypoglossal nerve development [Term] id: GO:0021620 name: hypoglossal nerve formation namespace: biological_process def: "The process that gives rise to the hypoglossal nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII biosynthesis" RELATED [] synonym: "CN XII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021621 name: hypoglossal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the hypoglossal nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all the intrinsic and all but one of the extrinsic muscles of the tongue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN XII structural organization" RELATED [] synonym: "hypoglossal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021618 ! hypoglossal nerve morphogenesis [Term] id: GO:0021622 name: oculomotor nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the oculomotor nerve is generated and organized. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021623 name: oculomotor nerve formation namespace: biological_process def: "The process that gives rise to the oculomotor nerve. This process pertains to the initial formation of a structure from unspecified parts. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III biosynthesis" RELATED [] synonym: "CN III formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021624 name: oculomotor nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III structural organization" RELATED [] synonym: "oculomotor nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021622 ! oculomotor nerve morphogenesis [Term] id: GO:0021625 name: oculomotor nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the oculomotor nerve to attain its fully functional state. This motor nerve innervates all extraocular muscles except the superior oblique and the lateral rectus muscles. The superior division supplies the levator palpebrae superioris and superior rectus muscles. The inferior division supplies the medial rectus, inferior rectus and inferior oblique muscles. This nerve also innervates the striated muscles of the eyelid. Pupillary constriction and lens movement are mediated by this nerve for near vision. In the orbit the inferior division sends branches that enter the ciliary ganglion where they form functional contacts (synapses) with the ganglion cells. The ganglion cells send nerve fibers into the back of the eye where they travel to ultimately innervate the ciliary muscle and the constrictor pupillae muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN III maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021557 ! oculomotor nerve development [Term] id: GO:0021626 name: central nervous system maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the central nervous system to attain its fully functional state. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0582227089] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021627 name: olfactory nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the olfactory nerve is generated and organized. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021628 name: olfactory nerve formation namespace: biological_process def: "The process that gives rise to the olfactory nerve. This process pertains to the initial formation of a structure from unspecified parts. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I biosynthesis" RELATED [] synonym: "CN I formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021629 name: olfactory nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN I structural organization" RELATED [] synonym: "olfactory nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021627 ! olfactory nerve morphogenesis [Term] id: GO:0021630 name: olfactory nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the olfactory nerve to attain its fully functional state. The olfactory nerve is a collection of sensory nerve rootlets that extend down from the olfactory bulb to the olfactory mucosa of the upper parts of the nasal cavity. This nerve conducts odor information to the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "CN I maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021553 ! olfactory nerve development [Term] id: GO:0021631 name: optic nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the optic nerve is generated and organized. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021632 name: optic nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the optic nerve to attain its fully functional state. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II maturation" EXACT [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021554 ! optic nerve development [Term] id: GO:0021633 name: optic nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the optic nerve. This process pertains to the physical shaping of a rudimentary structure. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II structural organization" RELATED [] synonym: "optic nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021634 name: optic nerve formation namespace: biological_process def: "The process that gives rise to the optic nerve. This process pertains to the initial formation of a structure from unspecified parts. The sensory optic nerve originates from the bipolar cells of the retina and conducts visual information to the brainstem. The optic nerve exits the back of the eye in the orbit, enters the optic canal, and enters the central nervous system at the optic chiasm (crossing) where the nerve fibers become the optic tract just prior to entering the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN II biosynthesis" RELATED [] synonym: "CN II formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021631 ! optic nerve morphogenesis [Term] id: GO:0021635 name: trigeminal nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trigeminal nerve to attain its fully functional state. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021636 name: trigeminal nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trigeminal nerve is generated and organized. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021559 ! trigeminal nerve development [Term] id: GO:0021637 name: trigeminal nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the oculomotor nerve. This process pertains to the physical shaping of a rudimentary structure. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V structural organization" RELATED [] synonym: "trigeminal nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021638 name: trigeminal nerve formation namespace: biological_process def: "The process that gives rise to the trigeminal nerve. This process pertains to the initial formation of a structure from unspecified parts. The trigeminal nerve is composed of three large branches. They are the ophthalmic (V1, sensory), maxillary (V2, sensory) and mandibular (V3, motor and sensory) branches. The sensory ophthalmic branch travels through the superior orbital fissure and passes through the orbit to reach the skin of the forehead and top of the head. The maxillary nerve contains sensory branches that reach the pterygopalatine fossa via the inferior orbital fissure (face, cheek and upper teeth) and pterygopalatine canal (soft and hard palate, nasal cavity and pharynx). The motor part of the mandibular branch is distributed to the muscles of mastication, the mylohyoid muscle and the anterior belly of the digastric. The mandibular nerve also innervates the tensor veli palatini and tensor tympani muscles. The sensory part of the mandibular nerve is composed of branches that carry general sensory information from the mucous membranes of the mouth and cheek, anterior two-thirds of the tongue, lower teeth, skin of the lower jaw, side of the head and scalp and meninges of the anterior and middle cranial fossae." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN V biosynthesis" RELATED [] synonym: "CN V formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021636 ! trigeminal nerve morphogenesis [Term] id: GO:0021639 name: trochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the trochlear nerve is generated and organized. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CH IV morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021640 name: trochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the trochlear nerve to attain its fully functional state. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021558 ! trochlear nerve development [Term] id: GO:0021641 name: trochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the trochlear nerve. This process pertains to the physical shaping of a rudimentary structure. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV structural organization" RELATED [] synonym: "trochlear nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021642 name: trochlear nerve formation namespace: biological_process def: "The process that gives rise to the trochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. The trochlear nerve is a motor nerve and is the only cranial nerve to exit the brain dorsally. The trochlear nerve innervates the superior oblique muscle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN IV biosynthesis" RELATED [] synonym: "CN IV formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021639 ! trochlear nerve morphogenesis [Term] id: GO:0021643 name: vagus nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vagus nerve to attain its fully functional state. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021644 name: vagus nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vagus nerve is generated and organized. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021564 ! vagus nerve development [Term] id: GO:0021645 name: vagus nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X structural organization" RELATED [] synonym: "vagus nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021646 name: vagus nerve formation namespace: biological_process def: "The process that gives rise to the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts. This nerve is primarily sensory but also has visceromotor components. It originates in the brain stem and controls many autonomic functions of the heart, lungs, stomach, pharynx, larynx, trachea, esophagus and other gastrointestinal tract components. It controls some motor functions such as speech. The sensory branches mediate sensation from the pharynx, larynx, thorax and abdomen; it also innervates taste buds in the epiglottis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN X biosynthesis" RELATED [] synonym: "CN X formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021644 ! vagus nerve morphogenesis [Term] id: GO:0021647 name: vestibulocochlear nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the vestibulocochlear nerve to attain its fully functional state. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "auditory nerve maturation" RELATED [] synonym: "CN VIII maturation" RELATED [] is_a: GO:0021605 ! cranial nerve maturation relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021648 name: vestibulocochlear nerve morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the vestibulocochlear nerve is generated and organized. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VIII morphogenesis" RELATED [] is_a: GO:0021602 ! cranial nerve morphogenesis relationship: part_of GO:0021562 ! vestibulocochlear nerve development [Term] id: GO:0021649 name: vestibulocochlear nerve structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the vestibulocochlear nerve. This process pertains to the physical shaping of a rudimentary structure. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII structural organization" RELATED [] synonym: "vestibulocochlear nerve structural organisation" EXACT [GOC:mah] is_a: GO:0021604 ! cranial nerve structural organization relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021650 name: vestibulocochlear nerve formation namespace: biological_process def: "The process that gives rise to the vestibulocochlear nerve. This process pertains to the initial formation of a structure from unspecified parts. This sensory nerve innervates the membranous labyrinth of the inner ear. The vestibular branch innervates the vestibular apparatus that senses head position changes relative to gravity. The auditory branch innervates the cochlear duct, which is connected to the three bony ossicles which transduce sound waves into fluid movement in the cochlea." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "CN VII formation" RELATED [] is_a: GO:0021603 ! cranial nerve formation relationship: part_of GO:0021648 ! vestibulocochlear nerve morphogenesis [Term] id: GO:0021651 name: rhombomere 1 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 1 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021567 ! rhombomere 1 development [Term] id: GO:0021652 name: rhombomere 1 formation namespace: biological_process def: "The process that gives rise to rhombomere 1. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021653 name: rhombomere 1 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 1. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 1 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021651 ! rhombomere 1 morphogenesis [Term] id: GO:0021654 name: rhombomere boundary formation namespace: biological_process def: "The process that gives rise to a rhombomere boundary. This process pertains to the initial formation of a boundary delimiting a rhombomere. Rhombomeres are transverse segments of the developing rhombencephalon that are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021594 ! rhombomere formation [Term] id: GO:0021655 name: rhombomere 2 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 2 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021568 ! rhombomere 2 development [Term] id: GO:0021656 name: rhombomere 2 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 2. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 2 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021657 name: rhombomere 2 formation namespace: biological_process def: "The process that gives rise to rhombomere 2. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021655 ! rhombomere 2 morphogenesis [Term] id: GO:0021658 name: rhombomere 3 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 3 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021569 ! rhombomere 3 development [Term] id: GO:0021659 name: rhombomere 3 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 3. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 3 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021660 name: rhombomere 3 formation namespace: biological_process def: "The process that gives rise to rhombomere 3. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021658 ! rhombomere 3 morphogenesis [Term] id: GO:0021661 name: rhombomere 4 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 4 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021570 ! rhombomere 4 development [Term] id: GO:0021662 name: rhombomere 4 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 4. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 4 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021663 name: rhombomere 4 formation namespace: biological_process def: "The process that gives rise to rhombomere 4. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021661 ! rhombomere 4 morphogenesis [Term] id: GO:0021664 name: rhombomere 5 morphogenesis namespace: biological_process def: "The process in which the anatomical structures of rhombomere 5 are generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021571 ! rhombomere 5 development [Term] id: GO:0021665 name: rhombomere 5 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 5. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 5 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021666 name: rhombomere 5 formation namespace: biological_process def: "The process that gives rise to rhombomere 5. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021664 ! rhombomere 5 morphogenesis [Term] id: GO:0021667 name: rhombomere 6 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 6 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021572 ! rhombomere 6 development [Term] id: GO:0021668 name: rhombomere 6 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 6. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 6 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021669 name: rhombomere 6 formation namespace: biological_process def: "The process that gives rise to rhombomere 6. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021667 ! rhombomere 6 morphogenesis [Term] id: GO:0021670 name: lateral ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral ventricles over time, from the formation to the mature structure. The two lateral ventricles are a cavity in each of the cerebral hemispheres derived from the cavity of the embryonic neural tube. They are separated from each other by the septum pellucidum, and each communicates with the third ventricle by the foramen of Monro, through which also the choroid plexuses of the lateral ventricles become continuous with that of the third ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021671 name: rhombomere 7 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 7 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021573 ! rhombomere 7 development [Term] id: GO:0021672 name: rhombomere 7 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 7. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 7 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021673 name: rhombomere 7 formation namespace: biological_process def: "The process that gives rise to rhombomere 7. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021671 ! rhombomere 7 morphogenesis [Term] id: GO:0021674 name: rhombomere 8 morphogenesis namespace: biological_process def: "The process in which the anatomical structure of rhombomere 8 is generated and organized. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021593 ! rhombomere morphogenesis relationship: part_of GO:0021574 ! rhombomere 8 development [Term] id: GO:0021675 name: nerve development namespace: biological_process def: "The process whose specific outcome is the progression of a nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0021676 name: rhombomere 8 structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of rhombomere 8. This process pertains to the physical shaping of a rudimentary structure. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in an anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rhombomere 8 structural organisation" EXACT [GOC:mah] is_a: GO:0021595 ! rhombomere structural organization relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021677 name: rhombomere 8 formation namespace: biological_process def: "The process that gives rise to rhombomere 8. This process pertains to the initial formation of a structure from unspecified parts. Rhombomeres are transverse segments of the developing rhombencephalon. Rhombomeres are lineage restricted, express different genes from one another, and adopt different developmental fates. Rhombomeres are numbered in anterior to posterior order." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021594 ! rhombomere formation relationship: part_of GO:0021674 ! rhombomere 8 morphogenesis [Term] id: GO:0021678 name: third ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of the third ventricle over time, from its formation to the mature structure. The third ventricle is the narrow cleft inferior to the corpus callosum, within the diencephalon, between the paired thalami. Its floor is formed by the hypothalamus, its anterior wall by the lamina terminalis, and its roof by ependyma, and it communicates with the fourth ventricle by the cerebral aqueduct, and with the lateral ventricles by the interventricular foramina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0683400078] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021591 ! ventricular system development [Term] id: GO:0021679 name: cerebellar molecular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar molecular layer nerve over time, from its formation to the mature structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021680 name: cerebellar Purkinje cell layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar Purkinje cell layer over time, from its formation to the mature structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021681 name: cerebellar granular layer development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar granule layer over time, from its formation to the mature structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021682 name: nerve maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a nerve to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021675 ! nerve development [Term] id: GO:0021683 name: cerebellar granular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar granular layer is generated and organized. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021684 name: cerebellar granular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar granule layer. This process pertains to the initial formation of a structure from unspecified parts. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021685 name: cerebellar granular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar granule layer. This process pertains to the physical shaping of a rudimentary structure. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar granular layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021683 ! cerebellar granular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021686 name: cerebellar granular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar granular layer to attain its fully functional state. The granular layer is the innermost layer of the cerebellar cortex. This layer contains densely packed small neurons, mostly granule cells. Some Golgi cells are found at the outer border. Granule neurons send parallel fibers to the upper molecular layer, where they synapse with Purkinje cell dendrites. Mossy fibers from the pontine nuclei in the white matter synapse with granule cell axons, Golgi cell axons and unipolar brush interneuron axons at cerebellar glomeruli in the granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021681 ! cerebellar granular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021687 name: cerebellar molecular layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar molecular layer is generated and organized. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021688 name: cerebellar molecular layer formation namespace: biological_process def: "The process that gives rise to the cerebellar molecular layer. This process pertains to the initial formation of a structure from unspecified parts. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021689 name: cerebellar molecular layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar molecular layer. This process pertains to the physical shaping of a rudimentary structure. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar molecular layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021687 ! cerebellar molecular layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021690 name: cerebellar molecular layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar molecular layer to attain its fully functional state. The molecular layer is the outermost layer of the cerebellar cortex. It contains the parallel fibers of the granule cells, interneurons such as stellate and basket cells, and the dendrites of the underlying Purkinje cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021679 ! cerebellar molecular layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021691 name: cerebellar Purkinje cell layer maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar Purkinje cell layer to attain its fully functional state. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021699 ! cerebellar cortex maturation [Term] id: GO:0021692 name: cerebellar Purkinje cell layer morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cerebellar Purkinje cell layer is generated and organized. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021680 ! cerebellar Purkinje cell layer development relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021693 name: cerebellar Purkinje cell layer structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar Purkinje cell layer. This process pertains to the physical shaping of a rudimentary structure. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar Purkinje cell layer structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021698 ! cerebellar cortex structural organization [Term] id: GO:0021694 name: cerebellar Purkinje cell layer formation namespace: biological_process def: "The process that gives rise to the cerebellar Purkinje cell layer. This process pertains to the initial formation of a structure from unspecified parts. The Purkinje cell layer lies just underneath the molecular layer of the cerebellar cortex. It contains the neuronal cell bodies of the Purkinje cells that are arranged side by side in a single layer. Candelabrum interneurons are vertically oriented between the Purkinje cells. Purkinje neurons are inhibitory and provide the output of the cerebellar cortex through axons that project into the white matter. Extensive dendritic trees from the Purkinje cells extend upward in a single plane into the molecular layer where they synapse with parallel fibers of granule cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021692 ! cerebellar Purkinje cell layer morphogenesis relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021695 name: cerebellar cortex development namespace: biological_process def: "The process whose specific outcome is the progression of the cerebellar cortex over time, from its formation to the mature structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021696 name: cerebellar cortex morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the cranial nerves are generated and organized. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021587 ! cerebellum morphogenesis relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021697 name: cerebellar cortex formation namespace: biological_process def: "The process that gives rise to the cerebellar cortex. This process pertains to the initial formation of a structure from unspecified parts. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021698 name: cerebellar cortex structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the cerebellar cortex. This process pertains to the physical shaping of a rudimentary structure. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "cerebellar cortex structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021696 ! cerebellar cortex morphogenesis [Term] id: GO:0021699 name: cerebellar cortex maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the cerebellar cortex to attain its fully functional state. The cerebellar cortex is a thin mantle of gray matter that covers the surface of each cerebral hemisphere. It has a characteristic morphology with convolutions (gyri) and crevices (sulci) that have specific functions. Six layers of nerve cells and the nerve pathways that connect them comprise the cerebellar cortex. Together, these regions are responsible for the processes of conscious thought, perception, emotion and memory as well as advanced motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021590 ! cerebellum maturation relationship: part_of GO:0021695 ! cerebellar cortex development [Term] id: GO:0021700 name: developmental maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an anatomical structure, cell or cellular component to attain its fully functional state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. subset: goslim_chembl subset: goslim_generic is_a: GO:0032502 ! developmental process [Term] id: GO:0021701 name: cerebellar Golgi cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Golgi cell. Differentiation includes the processes involved in commitment of a neuroblast to a Golgi cell fate. A cerebellar Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021702 name: cerebellar Purkinje cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar Purkinje cell. Differentiation includes the processes involved in commitment of a neuroblast to a Purkinje cell fate. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021703 name: locus ceruleus development namespace: biological_process def: "The process whose specific outcome is the progression of the locus ceruleus over time, from its formation to the mature structure. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "locus caeruleus development" EXACT [] synonym: "locus coeruleus development" EXACT [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021704 name: locus ceruleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the locus ceruleus is generated and organized. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021705 name: locus ceruleus formation namespace: biological_process def: "The process that gives rise to the locus ceruleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021704 ! locus ceruleus morphogenesis [Term] id: GO:0021706 name: locus ceruleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the locus ceruleus to attain its fully functional state. The locus ceruleus is a dense cluster of neurons within the dorsorostral pons. This nucleus is the major location of neurons that release norepinephrine throughout the brain, and is responsible for physiological responses to stress and panic." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021703 ! locus ceruleus development [Term] id: GO:0021707 name: cerebellar granule cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar granule cell. Differentiation includes the processes involved in commitment of a neuroblast to a granule cell fate. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021708 name: Lugaro cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature Lugaro cell. Differentiation includes the processes involved in commitment of a neuroblast to a Lugaro cell fate. A Lugaro cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021709 name: cerebellar basket cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar basket cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar basket cell fate. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021710 name: cerebellar stellate cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature cerebellar stellate cell. Differentiation includes the processes involved in commitment of a neuroblast to a cerebellar stellate cell fate. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021688 ! cerebellar molecular layer formation [Term] id: GO:0021711 name: cerebellar unipolar brush cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature unipolar brush cell in the cerebellum. Differentiation includes the processes involved in commitment of a neuroblast to a unipolar brush cell fate. A unipolar brush cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021684 ! cerebellar granular layer formation [Term] id: GO:0021712 name: candelabrum cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature candelabrum cell. Differentiation includes the processes involved in commitment of a neuroblast to a candelabrum cell fate. A candelabrum cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021694 ! cerebellar Purkinje cell layer formation [Term] id: GO:0021713 name: inferior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior olivary nucleus over time, from its formation to the mature structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021714 name: inferior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the inferior olivary nucleus is generated and organized. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021579 ! medulla oblongata morphogenesis relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021715 name: inferior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the inferior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive biosynthesis" RELATED [] synonym: "inferior olive formation" RELATED [] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021580 ! medulla oblongata formation relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021716 name: inferior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the inferior olivary nucleus structure. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olivary nucleus structural organisation" EXACT [GOC:mah] synonym: "inferior olive structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021581 ! medulla oblongata structural organization relationship: part_of GO:0021714 ! inferior olivary nucleus morphogenesis [Term] id: GO:0021717 name: inferior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the inferior olivary nucleus to attain its fully functional state. The inferior olivary nucleus is a capsule-shaped structure in the ventral medulla located just lateral and dorsal to the medullary pyramids. Neurons in the inferior olivary nucleus are the source of climbing fiber input to the cerebellar cortex; these neurons have been implicated in various functions, such as learning and timing of movements." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "inferior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021582 ! medulla oblongata maturation relationship: part_of GO:0021713 ! inferior olivary nucleus development [Term] id: GO:0021718 name: superior olivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior olivary nucleus over time, from its formation to the mature structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021719 name: superior olivary nucleus morphogenesis namespace: biological_process def: "The process in which the anatomical structure of the superior olivary nucleus is generated and organized. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive morphogenesis" RELATED [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0021583 ! pons morphogenesis relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021720 name: superior olivary nucleus formation namespace: biological_process def: "The process that gives rise to the superior olivary nucleus. This process pertains to the initial formation of a structure from unspecified parts. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021584 ! pons formation relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021721 name: superior olivary nucleus structural organization namespace: biological_process def: "The process that contributes to the act of creating the structural organization of the superior olivary nucleus structure. In mice, the superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olivary nucleus structural organisation" EXACT [GOC:mah] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0021585 ! pons structural organization relationship: part_of GO:0021719 ! superior olivary nucleus morphogenesis [Term] id: GO:0021722 name: superior olivary nucleus maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343] comment: This term was added by GO_REF:0000021. synonym: "superior olive maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0021586 ! pons maturation relationship: part_of GO:0021718 ! superior olivary nucleus development [Term] id: GO:0021723 name: medullary reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the medullary reticular formation over time, from its formation to the mature structure. The medullary reticular formation is a series of brain nuclei located in the medulla oblongata." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, http://en.wikipedia.org/wiki/Rhombencephalon, http://www.brainspan.org] comment: This term was added by GO_REF:0000021. synonym: "rhombencephalic reticular formation development" BROAD [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021724 name: inferior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000366] comment: This term was added by GO_REF:0000021. synonym: "inferior central nucleus development" BROAD [] synonym: "posterior raphe nucleus development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021725 name: superior raphe nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior raphe nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:curators, GOC:cvs, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:19003874, ZFA:0000440] comment: This term was added by GO_REF:0000021. synonym: "anterior raphe nucleus development" BROAD [] synonym: "superior central nucleus development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021726 name: lateral reticular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral reticular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021727 name: intermediate reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the intermediate reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "intermediate reticular nucleus development" EXACT [http://www.brainspan.org] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021728 name: inferior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021729 name: superior reticular formation development namespace: biological_process def: "The process whose specific outcome is the progression of the superior reticular formation over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021723 ! medullary reticular formation development [Term] id: GO:0021730 name: trigeminal sensory nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal sensory nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions from midbrain to spinal cord. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0021731 name: trigeminal motor nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the trigeminal motor nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021732 name: midbrain-hindbrain boundary maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "isthmus maturation" RELATED [] synonym: "MHB maturation" RELATED [] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0030917 ! midbrain-hindbrain boundary development [Term] id: GO:0021735 name: dentate nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dentate nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021736 name: globose nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the globose nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021737 name: emboliform nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the emboliform nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021738 name: fastigial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the fastigial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021549 ! cerebellum development [Term] id: GO:0021739 name: mesencephalic trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the mesencephalic trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021740 name: principal sensory nucleus of trigeminal nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the pontine nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. Note that this term was placed as a child of 'brain development' because the nucleus spans multiple brain regions. synonym: "pontine nucleus development" BROAD [GOC:dph] is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021741 name: spinal trigeminal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the spinal trigeminal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021730 ! trigeminal sensory nucleus development [Term] id: GO:0021742 name: abducens nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the abducens nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021743 name: hypoglossal nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the hypoglossal nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021744 name: dorsal motor nucleus of vagus nerve development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal motor nucleus of the vagus nerve over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021745 name: nucleus ambiguus development namespace: biological_process def: "The process whose specific outcome is the progression of the nucleus ambiguus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021746 name: solitary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the solitary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021747 name: cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021748 name: dorsal cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021749 name: ventral cochlear nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cochlear nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021747 ! cochlear nucleus development [Term] id: GO:0021750 name: vestibular nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the vestibular nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16221589] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development relationship: part_of GO:0021550 ! medulla oblongata development [Term] id: GO:0021751 name: salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of a salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021752 name: inferior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the inferior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021751 ! salivary nucleus development [Term] id: GO:0021753 name: superior salivary nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the superior salivary nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021751 ! salivary nucleus development [Term] id: GO:0021754 name: facial nucleus development namespace: biological_process def: "The process whose specific outcome is the progression of the facial nucleus over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021548 ! pons development [Term] id: GO:0021755 name: eurydendroid cell differentiation namespace: biological_process def: "The process in which neuroblasts acquire specialized structural and/or functional features that characterize the mature eurydendroid cell. Differentiation includes the processes involved in commitment of a neuroblast to a eurydendroid cell fate. A eurydendroid cell is an efferent neuron found in the cerebellar cortex of teleosts." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15892096] comment: This term was added by GO_REF:0000021. is_a: GO:0021533 ! cell differentiation in hindbrain is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021697 ! cerebellar cortex formation [Term] id: GO:0021756 name: striatum development namespace: biological_process def: "The progression of the striatum over time from its initial formation until its mature state. The striatum is a region of the forebrain consisting of the caudate nucleus, putamen and fundus striati." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "neostriatum development" EXACT [] synonym: "striate nucleus development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021757 name: caudate nucleus development namespace: biological_process def: "The progression of the caudate nucleus over time from its initial formation until its mature state. The caudate nucleus is the C-shaped structures of the striatum containing input neurons involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021758 name: putamen development namespace: biological_process def: "The progression of the putamen over time from its initial formation until its mature state. The putamen is the lens-shaped basal ganglion involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021759 name: globus pallidus development namespace: biological_process def: "The progression of the globus pallidus over time from its initial formation until its mature state. The globus pallidus is one of the basal ganglia involved with control of voluntary movement in the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "pallidum development" EXACT [PMID:16271465] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021761 name: limbic system development namespace: biological_process def: "The progression of the limbic system over time from its initial formation until its mature state. The limbic system is a collection of structures in the brain involved in emotion, motivation and emotional aspects of memory." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021762 name: substantia nigra development namespace: biological_process def: "The progression of the substantia nigra over time from its initial formation until its mature state. The substantia nigra is the layer of gray substance that separates the posterior parts of the cerebral peduncles (tegmentum mesencephali) from the anterior parts; it normally includes a posterior compact part with many pigmented cells (pars compacta) and an anterior reticular part whose cells contain little pigment (pars reticularis)." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0838580343, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0030901 ! midbrain development [Term] id: GO:0021763 name: subthalamic nucleus development namespace: biological_process def: "The progression of the subthalamic nucleus over time from its initial formation until its mature state. The subthalamic nucleus is the lens-shaped nucleus located in the ventral part of the subthalamus on the inner aspect of the internal capsule that is concerned with the integration of somatic motor function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "corpus luysi development" RELATED [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021539 ! subthalamus development [Term] id: GO:0021764 name: amygdala development namespace: biological_process def: "The progression of the amygdala over time from its initial formation until its mature state. The amygdala is an almond-shaped set of neurons in the medial temporal lobe of the brain that play a key role in processing emotions such as fear and pleasure." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021765 name: cingulate gyrus development namespace: biological_process def: "The progression of the cingulate gyrus over time from its initial formation until its mature state. The cingulate gyrus is a ridge in the cerebral cortex located dorsal to the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021766 name: hippocampus development namespace: biological_process def: "The progression of the hippocampus over time from its initial formation until its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420, UBERON:0002421] comment: This term was added by GO_REF:0000021. synonym: "hippocampal formation development" EXACT [ABA:HPF] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021767 name: mammillary body development namespace: biological_process def: "The progression of the mammillary body over time from its initial formation until its mature state. The mammillary body is a protrusion at the posterior end of the hypothalamus that contains hypothalamic nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021768 name: nucleus accumbens development namespace: biological_process def: "The progression of the nucleus accumbens over time from its initial formation until its mature state. The nucleus accumbens is a collection of pleomorphic cells in the caudal part of the anterior horn of the lateral ventricle, in the region of the olfactory tubercle, lying between the head of the caudate nucleus and the anterior perforated substance. It is part of the ventral striatum, a composite structure considered part of the basal ganglia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "accumbens nucleus development" EXACT [GOC:dgh] synonym: "ventral striatum development" BROAD [] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021756 ! striatum development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021769 name: orbitofrontal cortex development namespace: biological_process def: "The progression of the orbitofrontal cortex over time from its initial formation until its mature state. The orbitofrontal cortex is a cerebral cortex region located in the frontal lobe." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021770 name: parahippocampal gyrus development namespace: biological_process def: "The progression of the parahippocampal gyrus over time from its initial formation until its mature state. The parahippocampal gyrus is a ridge in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "hippocampal gyrus development" EXACT [GOC:dgh] xref: Wikipedia:parahippocampal_gyrus is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021771 name: lateral geniculate nucleus development namespace: biological_process def: "The progression of the lateral geniculate nucleus over time from its initial formation until its mature state. The lateral geniculate nucleus is the primary processor of visual information received from the retina." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "LGN development" EXACT [GOC:dgh] is_a: GO:0048857 ! neural nucleus development relationship: part_of GO:0021794 ! thalamus development [Term] id: GO:0021772 name: olfactory bulb development namespace: biological_process def: "The progression of the olfactory bulb over time from its initial formation until its mature state. The olfactory bulb coordinates neuronal signaling involved in the perception of smell. It receives input from the sensory neurons and outputs to the olfactory cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021773 name: striatal medium spiny neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a medium spiny neuron residing in the striatum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. synonym: "medium-sized spiny neuron differentiation" EXACT [PMID:25804741] synonym: "striatal MSN differentiation" EXACT [PMID:25804741] is_a: GO:0021879 ! forebrain neuron differentiation relationship: part_of GO:0021756 ! striatum development [Term] id: GO:0021774 name: retinoic acid receptor signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to a retinoic acid receptor in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:sdb_2009, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0060895 ! retinoic acid receptor signaling pathway involved in spinal cord dorsal/ventral patterning relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021775 name: smoothened signaling pathway involved in ventral spinal cord interneuron specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the ventral spinal cord that contributes to the commitment of the precursor cell to an interneuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord interneuron specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in ventral spinal cord interneuron specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021776 name: smoothened signaling pathway involved in spinal cord motor neuron cell fate specification namespace: biological_process def: "The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15936325] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in spinal cord motor neuron cell fate specification" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway involved in spinal cord motor neuron cell fate specification" EXACT [] is_a: GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021777 name: obsolete BMP signaling pathway involved in spinal cord association neuron specification namespace: biological_process def: "OBSOLETE. A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to its commitment to an association neuron fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: The reason for obsoletion is that this term represents a GO-CAM model. synonym: "BMP signalling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in spinal cord association neuron specification" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord association neuron specification" EXACT [] is_obsolete: true [Term] id: GO:0021778 name: oligodendrocyte cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oligodendrocyte in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021780 ! glial cell fate specification relationship: part_of GO:0021779 ! oligodendrocyte cell fate commitment [Term] id: GO:0021779 name: oligodendrocyte cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an oligodendrocyte." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0048709 ! oligodendrocyte differentiation [Term] id: GO:0021780 name: glial cell fate specification namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into a glial cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0021781 name: glial cell fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a glial cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021782 name: glial cell development namespace: biological_process def: "The process aimed at the progression of a glial cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048468 ! cell development relationship: part_of GO:0010001 ! glial cell differentiation [Term] id: GO:0021783 name: preganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a preganglionic parasympathetic fiber over time, from its formation to the mature structure. A preganglionic parasympathetic fiber is a cholinergic axonal fiber projecting from the CNS to a parasympathetic ganglion." [GO_REF:0000021, GOC:cjm, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] comment: This term was added by GO_REF:0000021. is_a: GO:0048731 ! system development relationship: part_of GO:0007417 ! central nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021784 name: postganglionic parasympathetic fiber development namespace: biological_process def: "The process whose specific outcome is the progression of the postganglionic portion of the parasympathetic fiber over time, from its formation to the mature structure. The parasympathetic fiber is one of the two divisions of the vertebrate autonomic nervous system. Parasympathetic nerves emerge cranially as pre ganglionic fibers from oculomotor, facial, glossopharyngeal and vagus and from the sacral region of the spinal cord. Most neurons are cholinergic and responses are mediated by muscarinic receptors. The parasympathetic system innervates, for example: salivary glands, thoracic and abdominal viscera, bladder and genitalia." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048483 ! autonomic nervous system development relationship: part_of GO:0007422 ! peripheral nervous system development relationship: part_of GO:0048486 ! parasympathetic nervous system development [Term] id: GO:0021785 name: branchiomotor neuron axon guidance namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "BMN axon guidance" EXACT [PMID:14699587] synonym: "branchial motor axon guidance" EXACT [PMID:14699587] synonym: "special visceral motor neuron axon guidance" EXACT [PMID:14699587] is_a: GO:0008045 ! motor neuron axon guidance [Term] id: GO:0021786 name: branchiomotor neuron axon guidance in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021787 name: chemorepulsion of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021788 name: chemoattraction of branchiomotor neuron axon in neural tube namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the neural tube is directed to a specific target site in the neural tube in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in neural tube" EXACT [GOC:mah] is_a: GO:0021786 ! branchiomotor neuron axon guidance in neural tube is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021789 name: branchiomotor neuron axon guidance in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. is_a: GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021790 name: chemorepulsion of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021793 ! chemorepulsion of branchiomotor axon [Term] id: GO:0021791 name: chemoattraction of branchiomotor neuron axon in branchial arch mesenchyme namespace: biological_process def: "The process in which a branchiomotor neuron growth cone in the branchial arch mesenchyme is directed to a specific target site in the branchial arch mesenchyme in response to an attractive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor neuron axon in branchial arch mesenchyme" EXACT [GOC:mah] is_a: GO:0021789 ! branchiomotor neuron axon guidance in branchial arch mesenchyme is_a: GO:0021792 ! chemoattraction of branchiomotor axon [Term] id: GO:0021792 name: chemoattraction of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to an attractive chemical signal. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0061642 ! chemoattraction of axon relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021793 name: chemorepulsion of branchiomotor axon namespace: biological_process def: "The process in which a branchiomotor neuron growth cone is directed to a specific target site in response to a repulsive chemical cue. Branchiomotor neurons are located in the hindbrain and innervate branchial arch-derived muscles that control jaw movements, facial expression, the larynx, and the pharynx." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:14699587] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis of branchiomotor axon" EXACT [GOC:mah] is_a: GO:0061643 ! chemorepulsion of axon relationship: part_of GO:0021785 ! branchiomotor neuron axon guidance [Term] id: GO:0021794 name: thalamus development namespace: biological_process def: "The process in which the thalamus changes over time, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development [Term] id: GO:0021795 name: cerebral cortex cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021796 name: cerebral cortex regionalization namespace: biological_process def: "The regionalization process that results in the creation of areas within the cerebral cortex that will direct the behavior of cell migration and differentiation as the cortex develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex arealization" EXACT [] synonym: "cerebral cortex pattern biosynthesis" EXACT [] synonym: "cerebral cortex pattern formation" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0021978 ! telencephalon regionalization relationship: part_of GO:0021987 ! cerebral cortex development [Term] id: GO:0021797 name: forebrain anterior/posterior pattern specification namespace: biological_process def: "The creation of specific areas of progenitor domains along the anterior-posterior axis of the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain anterior-posterior pattern specification" EXACT [] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021798 name: forebrain dorsal/ventral pattern formation namespace: biological_process def: "The formation of specific regional progenitor domains along the dorsal-ventral axis in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "forebrain dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "forebrain dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021799 name: cerebral cortex radially oriented cell migration namespace: biological_process def: "The migration of cells in the developing cerebral cortex in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021800 name: cerebral cortex tangential migration namespace: biological_process def: "The migration of cells in the cerebral cortex in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021795 ! cerebral cortex cell migration [Term] id: GO:0021801 name: cerebral cortex radial glia guided migration namespace: biological_process def: "The radial migration of neuronal or glial precursor cells along radial glial cells during the development of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glial-guided locomotion" RELATED [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0021802 name: somal translocation namespace: biological_process def: "The radial migration of cells from the ventricular zone that is independent of radial glial cells. Cells extend processes that terminate at the pial surface and follow the processes as they migrate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "perikaryal translocation of Morest" EXACT [PMID:12626695] is_a: GO:0021799 ! cerebral cortex radially oriented cell migration [Term] id: GO:0021803 name: extension of leading cell process to pial surface namespace: biological_process def: "The extension of a long process to the pial surface as a cell leaves the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021804 name: negative regulation of cell adhesion in ventricular zone namespace: biological_process def: "The process that results in the loss of attachments of a cell in the ventricular zone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell adhesion in ventricular zone" EXACT [] synonym: "down-regulation of cell adhesion in ventricular zone" EXACT [] synonym: "downregulation of cell adhesion in ventricular zone" EXACT [] synonym: "inhibition of cell adhesion in ventricular zone" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021805 name: cell movement involved in somal translocation namespace: biological_process def: "The movement of a cell body from the ventricular zone to the pial surface with a concomitant shortening of the process that extends to the pial surface." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell motility involved in somal translocation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0021802 ! somal translocation [Term] id: GO:0021806 name: initiation of movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The initial stages of cell motility involved in the glial-mediated movement of cells in the developing cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "initiation of movement involved in cerebral cortex glial-mediated radial migration" RELATED [GOC:dph] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0001667 ! ameboidal-type cell migration relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021807 name: motogenic signaling initiating cell movement in cerebral cortex namespace: biological_process def: "The interaction of soluble factors and receptors that result in the movement of cells in the primitive cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling initiating cell movement in the cerebral cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021808 name: cytosolic calcium signaling involved in initiation of cell movement in glial-mediated radial cell migration namespace: biological_process def: "The process that results in the fluctuations in intracellular calcium that are responsible for the initiation of movement as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cytosolic calcium signalling involved in the initiation of cell movement in glial-mediated radial cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling relationship: part_of GO:0021806 ! initiation of movement involved in cerebral cortex radial glia guided migration [Term] id: GO:0021809 name: neurotrophic factor signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between members of the neurotrophin family and their receptors that result in the start of cell motility as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotrophic factor signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021810 name: neurotransmitter signaling initiating cell movement, involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling by neurotransmitters and their receptors that results in the initiation of movement of cells as a component of the process of glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neurotransmitter signalling initiating cell movement, involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021811 name: growth factor signaling initiating cell movement involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Signaling between growth factors and their receptors that results in the start of cell movement, where this process is involved in glial-mediated radial migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "growth factor signaling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:mtg_cardio] synonym: "growth factor signalling initiating cell movement involved in cerebral cortex glial-mediated radial migration" EXACT [] is_a: GO:0021807 ! motogenic signaling initiating cell movement in cerebral cortex [Term] id: GO:0021812 name: neuronal-glial interaction involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in adhesion between neuronal cells and glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuronal-glial interaction involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021813 name: cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The interaction between two cells that modulates the association of a neuronal cell and a glial cell involved in glial-mediated radial cell migration in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell-cell adhesion involved in neuronal-glial interactions involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules relationship: part_of GO:0021812 ! neuronal-glial interaction involved in cerebral cortex radial glia guided migration [Term] id: GO:0021814 name: cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The movement of a cell along the process of a radial glial cell involved in cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph] is_a: GO:0048870 ! cell motility relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021815 name: modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration namespace: biological_process def: "Rearrangements of the microtubule cytoskeleton that contribute to the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of microtubule cytoskeleton involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021816 name: extension of a leading process involved in cell motility in cerebral cortex radial glia guided migration namespace: biological_process def: "The rearrangements of the microtubule cytoskeleton that result in the extension of a leading process, where this process is involved in the movement of cells along radial glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration is_a: GO:0031269 ! pseudopodium assembly [Term] id: GO:0021817 name: nucleokinesis involved in cell motility in cerebral cortex radial glia guided migration namespace: biological_process def: "The microtubule-mediated movement of the nucleus that is required for the movement of cells along radial glial fibers as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "nucleokinesis involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "nucleokinesis involved in cell locomotion in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule relationship: part_of GO:0021815 ! modulation of microtubule cytoskeleton involved in cerebral cortex radial glia guided migration [Term] id: GO:0021818 name: modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex radial glia guided migration namespace: biological_process def: "The changes in the actin cytoskeleton that are necessary for the movement of cells along radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "modulation of the microfilament cytoskeleton involved in cell locomotion in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030036 ! actin cytoskeleton organization relationship: part_of GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration [Term] id: GO:0021819 name: layer formation in cerebral cortex namespace: biological_process def: "The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "cerebral cortex lamination" RELATED [PMID:12626695] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021801 ! cerebral cortex radial glia guided migration [Term] id: GO:0021820 name: extracellular matrix organization in marginal zone involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The process that leads to the deposition of extracellular matrix signals in the marginal zone of the developing cerebral cortex. This extracellular matrix controls the movement of migrating cells. In mammals, the matrix is modified by Cajal-Retzius cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "extracellular matrix organisation in marginal zone involved in cerebral cortex radial glia guided migration" EXACT [GOC:mah] synonym: "organization of extracellular matrix in the marginal zone involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021821 name: negative regulation of cell-glial cell adhesion involved in cerebral cortex lamination namespace: biological_process def: "The process that results in the release of migrating cells from their interaction with radial glial cells as a component of the process of cerebral cortex glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "down-regulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "downregulation of cell-glial cell adhesion involved in cerebral cortex lamination" EXACT [] synonym: "inhibition of cell-glial cell adhesion involved in cerebral cortex lamination" NARROW [] is_a: GO:0022408 ! negative regulation of cell-cell adhesion relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021822 name: negative regulation of cell motility involved in cerebral cortex radial glia guided migration namespace: biological_process def: "The intracellular signaling pathway that results in the cessation of cell movement involved in lamination of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "down regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "down-regulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "downregulation of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" EXACT [] synonym: "inhibition of cell locomotion involved in cerebral cortex glial-mediated radial cell migration" NARROW [] synonym: "negative regulation of cell locomotion involved in cerebral cortex glial-mediated radial migration" EXACT [GOC:dph] synonym: "negative regulation of cell locomotion involved in cerebral cortex radial glia guided migration" RELATED [GOC:dph, GOC:tb] is_a: GO:1903976 ! negative regulation of glial cell migration relationship: negatively_regulates GO:0021814 ! cell motility involved in cerebral cortex radial glia guided migration relationship: part_of GO:0021819 ! layer formation in cerebral cortex [Term] id: GO:0021823 name: cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The process in which neurons interact with each other to promote migration along a tangential plane." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "chain migration" RELATED [PMID:12626695] is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021824 name: cerebral cortex tangential migration using cell-axon interactions namespace: biological_process def: "The movement of cerebral cortex neuronal precursors tangentially through the cortex using interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021825 ! substrate-dependent cerebral cortex tangential migration [Term] id: GO:0021825 name: substrate-dependent cerebral cortex tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the cerebral cortex, primarily guided through physical cell-cell interactions." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0006929 ! substrate-dependent cell migration is_a: GO:0021800 ! cerebral cortex tangential migration [Term] id: GO:0021826 name: substrate-independent telencephalic tangential migration namespace: biological_process def: "The process where neuronal precursors migrate tangentially in the telencephalon, primarily guided by interactions that do not require cell-cell contact." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0021827 name: postnatal olfactory bulb interneuron migration namespace: biological_process def: "The migration of olfactory bulb interneuron precursors in the cerebral cortex that occurs after birth." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021828 name: gonadotrophin-releasing hormone neuronal migration to the hypothalamus namespace: biological_process alt_id: GO:0021857 def: "The directional movement of a gonadotrophin-releasing hormone producing neuron from the nasal placode to the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "gonadotropin-releasing hormone neuronal migration to the hypothalamus" EXACT [GOC:dph] is_a: GO:0001764 ! neuron migration is_a: GO:0021824 ! cerebral cortex tangential migration using cell-axon interactions is_a: GO:0021856 ! hypothalamic tangential migration using cell-axon interactions relationship: part_of GO:0021888 ! hypothalamus gonadotrophin-releasing hormone neuron development [Term] id: GO:0021829 name: oligodendrocyte cell migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of oligodendrocytes from the subpallium to the cerebral cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0021830 name: interneuron migration from the subpallium to the cortex namespace: biological_process def: "The directed movement of interneurons from the subpallium to the cortex during forebrain development." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021831 name: embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The directed movement of individual interneuron precursors during the embryonic development of the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021843 ! substrate-independent telencephalic tangential interneuron migration is_a: GO:0022028 ! tangential migration from the subventricular zone to the olfactory bulb relationship: part_of GO:0021891 ! olfactory bulb interneuron development [Term] id: GO:0021832 name: cell-cell adhesion involved in cerebral cortex tangential migration using cell-cell interactions namespace: biological_process def: "The attachment of cells to one another to form groups of cells involved in cerebral cortex tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0098742 ! cell-cell adhesion via plasma-membrane adhesion molecules relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021833 name: cell-matrix adhesion involved in tangential migration using cell-cell interactions namespace: biological_process def: "The interaction of a cell and the extracellular matrix involved in the directed tangential movement of cells mediated by cell-cell interactions in the developing cerebral cortex." [GO_REF:0000021, GOC:ascb_2009, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021823 ! cerebral cortex tangential migration using cell-cell interactions [Term] id: GO:0021834 name: chemorepulsion involved in embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The creation and reception of signals that guide olfactory bulb interneuron precursors down concentration gradients towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021835 name: chemoattraction involved in embryonic olfactory bulb interneuron precursor migration namespace: biological_process def: "The creation and reception of signals that result in the migration of interneuron precursors up a concentration gradient towards the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in embryonic olfactory bulb interneuron precursor migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021831 ! embryonic olfactory bulb interneuron precursor migration [Term] id: GO:0021836 name: chemorepulsion involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The creation and reception of signals that repel olfactory bulb interneurons from the subventricular zone as a component process in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in postnatal olfactory bulb interneuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021837 name: motogenic signaling involved in postnatal olfactory bulb interneuron migration namespace: biological_process def: "The signaling that results in the stimulation of cell movement in the rostral migratory stream." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in postnatal olfactory bulb interneuron migration" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021827 ! postnatal olfactory bulb interneuron migration [Term] id: GO:0021838 name: motogenic signaling involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the directional movement of interneuron precursors from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "motogenic signalling involved in interneuron migration from the subpallium to the cortex" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021839 name: interneuron-substratum interaction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The process in which migrating interneurons interact with an external substratum as a component of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021840 name: directional guidance of interneurons involved in migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that control the direction of migration of interneurons as a component of the process of migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021830 ! interneuron migration from the subpallium to the cortex [Term] id: GO:0021841 name: chemoattraction involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons toward the signal, where this process is involved in migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021842 name: chemorepulsion involved in interneuron migration from the subpallium to the cortex namespace: biological_process def: "The creation and reception of signals that result in the movement of interneurons away from the signal during migration from the subpallium to the cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in interneuron migration from the subpallium to the cortex" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021840 ! directional guidance of interneurons involved in migration from the subpallium to the cortex [Term] id: GO:0021843 name: substrate-independent telencephalic tangential interneuron migration namespace: biological_process def: "The directional movement of tangentially migrating interneurons that are not guided by attaching to extracellular substrates." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021826 ! substrate-independent telencephalic tangential migration [Term] id: GO:0021844 name: interneuron sorting involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The establishment and response to guidance cues that distribute interneurons to different cerebral cortex structures." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0042330 ! taxis relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021845 name: neurotransmitter-mediated guidance of interneurons involved in substrate-independent cerebral cortex tangential migration namespace: biological_process def: "The response of migrating interneurons to neurotransmitters that alter electrical activity in cells in calcium dependent manner." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0030334 ! regulation of cell migration relationship: part_of GO:0021843 ! substrate-independent telencephalic tangential interneuron migration [Term] id: GO:0021846 name: cell proliferation in forebrain namespace: biological_process def: "The creation of greater cell numbers in the forebrain due to cell division of progenitor cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021847 name: ventricular zone neuroblast division namespace: biological_process def: "The proliferation of neuroblasts in the ventricular zone of the cerebral cortex. The neuronal progenitors of these cells will migrate radially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in ventricular zone" EXACT [GOC:curators] is_a: GO:0021869 ! forebrain ventricular zone progenitor cell division is_a: GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021848 name: neuroblast division in subpallium namespace: biological_process def: "The division of neuroblasts in the subpallium area of the forebrain. The interneuron precursors that these cells give rise to include GABAergic interneurons and will migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "neuroblast division in the ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021849 name: neuroblast division in subventricular zone namespace: biological_process def: "The division of neuroblasts in the subventricular zone of the forebrain. The interneuron precursors that these cells give rise to include adult olfactory bulb interneurons and migrate tangentially." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021850 name: subpallium glioblast cell division namespace: biological_process def: "The division of glioblasts in the subpallium. These cells will give rise to oligodendrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in subpallium" EXACT [GOC:curators] synonym: "glioblast division in ventral telencephalon" EXACT [PMID:16226447] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0021851 name: neuroblast division in dorsal lateral ganglionic eminence namespace: biological_process def: "The division of neuroblasts in the dorsal region of the lateral ganglionic eminence. These cells give rise to embryonic interneuron precursors that will migrate tangentially to the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021848 ! neuroblast division in subpallium [Term] id: GO:0021852 name: pyramidal neuron migration namespace: biological_process def: "The migration of pyramidal a neuron precursor from the ventricular zone to the correct layer of the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "projection neuron migration" RELATED [PMID:12626695] is_a: GO:0001764 ! neuron migration is_a: GO:0021801 ! cerebral cortex radial glia guided migration relationship: part_of GO:0021860 ! pyramidal neuron development [Term] id: GO:0021853 name: cerebral cortex GABAergic interneuron migration namespace: biological_process def: "The migration of GABAergic interneuron precursors from the subpallium to the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021830 ! interneuron migration from the subpallium to the cortex is_a: GO:1904936 ! interneuron migration relationship: part_of GO:0021894 ! cerebral cortex GABAergic interneuron development [Term] id: GO:0021854 name: hypothalamus development namespace: biological_process def: "The progression of the hypothalamus region of the forebrain, from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0021761 ! limbic system development [Term] id: GO:0021855 name: hypothalamus cell migration namespace: biological_process def: "The directed movement of a cell into the hypothalamus region of the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021856 name: hypothalamic tangential migration using cell-axon interactions namespace: biological_process def: "The movement of a hypothalamic neuronal precursor tangentially through the forebrain using an interaction of the migrating cells with axons of other neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021855 ! hypothalamus cell migration [Term] id: GO:0021858 name: GABAergic neuron differentiation in basal ganglia namespace: biological_process def: "The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic inhibitory neuron in the basal ganglia. Differentiation includes the processes involved in commitment of a neuroblast to a GABAergic neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0097154 ! GABAergic neuron differentiation [Term] id: GO:0021859 name: pyramidal neuron differentiation namespace: biological_process def: "The process in which a neuroblast or one of its progeny commits to a pyramidal neuron fate, migrates from the ventricular zone to the appropriate layer in the cortex and develops into a mature neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron differentiation" BROAD [PMID:16226447] is_a: GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021860 name: pyramidal neuron development namespace: biological_process def: "The progression of a pyramidal neuron from its initial formation to its mature state." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "projection neuron development" BROAD [PMID:16226447] is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021859 ! pyramidal neuron differentiation [Term] id: GO:0021861 name: forebrain radial glial cell differentiation namespace: biological_process def: "The process in which neuroepithelial cells of the neural tube give rise to radial glial cells, specialized bipotential progenitors cells of the forebrain. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "radial glial cell differentiation in forebrain" EXACT [GOC:curators] is_a: GO:0060019 ! radial glial cell differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021862 name: early neuron differentiation in forebrain namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of neurons. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021863 name: forebrain neuroblast differentiation namespace: biological_process def: "The process in which neuroepithelial cells in the neural tube acquire specialized structural and/or functional features of basal progenitor cells, neuroblasts that lose their contacts with the ventricular surface. Differentiation includes the processes involved in commitment of a cell to a specific fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "abventricular progenitor cell differentiation" EXACT [PMID:16226447] synonym: "intermediate progenitor cell differentiation" EXACT [PMID:16226447] synonym: "non-surface dividing progenitor cell differentiation" EXACT [PMID:16226447] is_a: GO:0014016 ! neuroblast differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021864 name: obsolete radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic division of radial glial cells in the developing forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021865 name: obsolete symmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic division of a radial glial cell giving rise to two new radial glial cells in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021866 name: obsolete asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The mitotic cell division of a radial glial cell giving rise to a radial glial cell and another cell type." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021867 name: obsolete neuron-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The unequal mitotic division of a radial glial cell in the forebrain that gives rise to a radial glial cell and a post-mitotic neuronal progenitor." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021868 name: obsolete ventricular zone cell-producing asymmetric radial glial cell division in forebrain namespace: biological_process def: "OBSOLETE. The unequal mitotic division of a forebrain radial glial cell that gives rise to a radial glial cell and a ventricular zone cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0021869 name: forebrain ventricular zone progenitor cell division namespace: biological_process def: "The mitotic division of a basal progenitor giving rise to two neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0021870 name: Cajal-Retzius cell differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized structural and/or functional features of a Cajal-Retzius cell, one of a transient population of pioneering neurons in the cerebral cortex. These cells are slender bipolar cells of the developing marginal zone. One feature of these cells in mammals is that they express the Reelin gene." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021895 ! cerebral cortex neuron differentiation [Term] id: GO:0021871 name: forebrain regionalization namespace: biological_process def: "The regionalization process resulting in the creation of areas within the forebrain that will direct the behavior of cell migration in differentiation as the forebrain develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:isa_complete, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021872 name: forebrain generation of neurons namespace: biological_process def: "The process in which nerve cells are generated in the forebrain. This includes the production of neuroblasts from and their differentiation into neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "generation of neurons in forebrain" EXACT [GOC:curators] is_a: GO:0048699 ! generation of neurons relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021873 name: forebrain neuroblast division namespace: biological_process def: "The division of a neuroblast located in the forebrain. Neuroblast division gives rise to at least another neuroblast." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0055057 ! neuroblast division relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021874 name: Wnt signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in forebrain neuroblast division" EXACT [] synonym: "Wnt receptor signalling pathway in forebrain neuroblast division" EXACT [] synonym: "Wnt-activated signaling pathway involved in forebrain neuroblast division" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021875 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021876 name: Notch signaling pathway involved in forebrain neuroblast division namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the self renewal of neuroblasts in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway in forebrain neuroblast division" EXACT [] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0021873 ! forebrain neuroblast division [Term] id: GO:0021877 name: forebrain neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021878 name: forebrain astrocyte fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into an astrocyte that resides in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0060018 ! astrocyte fate commitment relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021879 name: forebrain neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0021872 ! forebrain generation of neurons [Term] id: GO:0021880 name: Notch signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Notch signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021881 name: Wnt-activated signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell that contributes to the commitment of a neuroblast to aneuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "Wnt receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "Wnt-activated signaling pathway involved in forebrain neuron fate commitment" RELATED [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021882 name: regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021883 name: cell cycle arrest of committed forebrain neuronal progenitor cell namespace: biological_process def: "The process in which the cell cycle is halted during one of the normal phases (G1, S, G2, M) in a cell that has been committed to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0007050 ! cell cycle arrest is_a: GO:0007406 ! negative regulation of neuroblast proliferation is_a: GO:1904676 ! negative regulation of somatic stem cell division relationship: negatively_regulates GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021884 name: forebrain neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron that resides in the forebrain, from its initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021954 ! central nervous system neuron development relationship: part_of GO:0021879 ! forebrain neuron differentiation [Term] id: GO:0021885 name: forebrain cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016477 ! cell migration relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021886 name: hypothalamus gonadotrophin-releasing hormone neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron located in the hypothalamus. These neurons release gonadotrophin-releasing hormone as a neural transmitter." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron differentiation" EXACT [GOC:dph] is_a: GO:0021979 ! hypothalamus cell differentiation [Term] id: GO:0021887 name: hypothalamus gonadotrophin-releasing hormone neuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a hypothalamus neuron that releases gonadotrophin-releasing hormone." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron fate commitment" RELATED [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021888 name: hypothalamus gonadotrophin-releasing hormone neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a hypothalamus gonadotrophin-releasing hormone neuron over time, from initial commitment of its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. synonym: "hypothalamus gonadotropin-releasing hormone neuron development" RELATED [GOC:dph] is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021886 ! hypothalamus gonadotrophin-releasing hormone neuron differentiation [Term] id: GO:0021889 name: olfactory bulb interneuron differentiation namespace: biological_process def: "The process in which a neuroblast acquires specialized features of an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0021890 name: olfactory bulb interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into an interneuron residing in the olfactory bulb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021891 name: olfactory bulb interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of an interneuron residing in the olfactory bulb, from its initial commitment, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021889 ! olfactory bulb interneuron differentiation [Term] id: GO:0021892 name: cerebral cortex GABAergic interneuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021879 ! forebrain neuron differentiation is_a: GO:0021895 ! cerebral cortex neuron differentiation is_a: GO:0097154 ! GABAergic neuron differentiation [Term] id: GO:0021893 name: cerebral cortex GABAergic interneuron fate commitment namespace: biological_process def: "The process in which the developmental fate of a neuroblast becomes restricted such that it will develop into a GABAergic interneuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021894 name: cerebral cortex GABAergic interneuron development namespace: biological_process def: "The process whose specific outcome is the progression of a cerebral cortex GABAergic interneuron over time, from initial commitment to its fate, to the fully functional differentiated cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021884 ! forebrain neuron development relationship: part_of GO:0021892 ! cerebral cortex GABAergic interneuron differentiation [Term] id: GO:0021895 name: cerebral cortex neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron residing in the cerebral cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021953 ! central nervous system neuron differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021896 name: forebrain astrocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of an astrocyte residing in the forebrain. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0048708 ! astrocyte differentiation relationship: part_of GO:0030900 ! forebrain development [Term] id: GO:0021897 name: forebrain astrocyte development namespace: biological_process def: "The process aimed at the progression of an astrocyte that resides in the forebrain, from initial commitment of the cell to its fate, to the fully functional differentiated cell. An astrocyte is the most abundant type of glial cell. Astrocytes provide support for neurons and regulate the environment in which they function." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0014002 ! astrocyte development relationship: part_of GO:0021896 ! forebrain astrocyte differentiation [Term] id: GO:0021898 name: commitment of multipotent stem cells to neuronal lineage in forebrain namespace: biological_process def: "The initial commitment of cells whereby the developmental fate of a cell becomes restricted such that it will develop into some type of neuron in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12626695] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021899 name: fibroblast growth factor receptor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0021900 name: ventricular zone cell fate commitment namespace: biological_process def: "The commitment of neuroblast to become a basal progenitor cell. Basal progenitor cells are neuronal precursor cells that are committed to becoming neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021863 ! forebrain neuroblast differentiation [Term] id: GO:0021901 name: early neuron fate commitment in forebrain namespace: biological_process def: "The commitment of neuroepithelial cell to become a neuron that will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021862 ! early neuron differentiation in forebrain [Term] id: GO:0021902 name: commitment of neuronal cell to specific neuron type in forebrain namespace: biological_process def: "The commitment of neuronal precursor cells to become specialized types of neurons in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:16226447] comment: This term was added by GO_REF:0000021. is_a: GO:0021877 ! forebrain neuron fate commitment [Term] id: GO:0021903 name: rostrocaudal neural tube patterning namespace: biological_process def: "The process in which the neural tube is divided into specific regions along the rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "anterior-posterior neural tube patterning" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021904 name: dorsal/ventral neural tube patterning namespace: biological_process def: "The process in which the neural tube is regionalized in the dorsoventral axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "dorsal-ventral neural tube patterning" EXACT [GOC:dph] synonym: "dorsoventral neural tube patterning" EXACT [GOC:mah] is_a: GO:0009953 ! dorsal/ventral pattern formation relationship: part_of GO:0021532 ! neural tube patterning [Term] id: GO:0021905 name: forebrain-midbrain boundary formation namespace: biological_process def: "The process whose specific outcome is the creation of the forebrain-midbrain boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021906 name: hindbrain-spinal cord boundary formation namespace: biological_process def: "The process whose specific outcome is the formation of the hindbrain-spinal cord boundary." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0021907 name: fibroblast growth factor receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "fibroblast growth factor receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021908 name: retinoic acid receptor signaling pathway involved in spinal cord anterior/posterior pattern formation namespace: biological_process def: "The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid receptor signalling pathway in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0048384 ! retinoic acid receptor signaling pathway relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021909 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord anterior-posterior patterning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0006357 ! regulation of transcription by RNA polymerase II relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021910 name: smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that results in the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021911 name: retinoic acid metabolic process in spinal cord anterior-posterior patterning namespace: biological_process def: "The chemical reactions and pathways involving the synthesis and degradation of retionic acid that results in the spatial identity of regions along the anterior-posterior axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "retinoic acid metabolism in spinal cord anterior-posterior patterning" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process relationship: part_of GO:0021512 ! spinal cord anterior/posterior patterning [Term] id: GO:0021912 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord motor neuron fate specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results the commitment of a cell to become a motor neuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021520 ! spinal cord motor neuron cell fate specification [Term] id: GO:0021913 name: regulation of transcription from RNA polymerase II promoter involved in ventral spinal cord interneuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that results in the commitment of a cell to become an interneuron in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021521 ! ventral spinal cord interneuron specification [Term] id: GO:0021914 name: negative regulation of smoothened signaling pathway involved in ventral spinal cord patterning namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of smoothened signaling that is involved in the patterns of cell differentiation in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "down regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "down-regulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "downregulation of smoothened signaling pathway in ventral spinal cord patterning" EXACT [] synonym: "inhibition of smoothened signaling pathway in ventral spinal cord patterning" NARROW [] synonym: "negative regulation of hedgehog signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of hh signaling pathway involved in ventral spinal cord patterning" EXACT [GOC:bf, GOC:ecd] synonym: "negative regulation of smoothened signalling pathway in ventral spinal cord patterning" EXACT [] is_a: GO:0045879 ! negative regulation of smoothened signaling pathway is_a: GO:0051961 ! negative regulation of nervous system development relationship: negatively_regulates GO:0021910 ! smoothened signaling pathway involved in ventral spinal cord patterning relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021915 name: neural tube development namespace: biological_process def: "The process whose specific outcome is the progression of the neural tube over time, from its formation to the mature structure. The mature structure of the neural tube exists when the tube has been segmented into the forebrain, midbrain, hindbrain and spinal cord regions. In addition neural crest has budded away from the epithelium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0035295 ! tube development is_a: GO:0060429 ! epithelium development relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0021916 name: inductive cell-cell signaling between paraxial mesoderm and motor neuron precursors namespace: biological_process def: "Short range signaling between cells of the paraxial mesoderm and motor neuron precursors in the spinal cord that specifies the fate of the motor column neuron precursors along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. synonym: "inductive cell-cell signalling between paraxial mesoderm and motor neuron precursors" EXACT [] is_a: GO:0031129 ! inductive cell-cell signaling relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021917 name: somatic motor neuron fate commitment namespace: biological_process def: "The commitment of unspecified motor neurons to specific motor neuron cell along the anterior-posterior axis of the spinal cord and their capacity to differentiate into specific motor neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0021523 ! somatic motor neuron differentiation [Term] id: GO:0021918 name: regulation of transcription from RNA polymerase II promoter involved in somatic motor neuron fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of spinal cord motor neurons to specific motor neuron types along the anterior-posterior axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11262869] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021917 ! somatic motor neuron fate commitment [Term] id: GO:0021919 name: BMP signaling pathway involved in spinal cord dorsal/ventral patterning namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the spatial identity of regions along the dorsal-ventral axis of the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "BMP signaling pathway in spinal cord dorsoventral patterning" EXACT [GOC:mah] synonym: "BMP signaling pathway involved in spinal cord dorsal-ventral patterning" EXACT [GOC:mah] synonym: "BMP signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signaling pathway in spinal cord dorsal-ventral patterning" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in spinal cord dorsal-ventral patterning" EXACT [] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0021513 ! spinal cord dorsal/ventral patterning [Term] id: GO:0021920 name: regulation of transcription from RNA polymerase II promoter involved in spinal cord association neuron specification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the commitment of neuronal precursors to association neurons in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. is_a: GO:0060850 ! regulation of transcription involved in cell fate commitment relationship: part_of GO:0021519 ! spinal cord association neuron specification [Term] id: GO:0021921 name: regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The process that modulates the frequency, rate or extent of cell proliferation in the dorsal spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: part_of GO:0021516 ! dorsal spinal cord development relationship: regulates GO:0010456 ! cell proliferation in dorsal spinal cord [Term] id: GO:0021922 name: Wnt signaling pathway involved in regulation of cell proliferation in dorsal spinal cord namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of a cell in the dorsal spinal cord that affects the rate of its division." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981] comment: This term was added by GO_REF:0000021. synonym: "Wnt receptor signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] synonym: "Wnt receptor signalling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [] synonym: "Wnt-activated signaling pathway involved in regulation of cell proliferation in dorsal spinal cord" EXACT [GOC:signaling] is_a: GO:0016055 ! Wnt signaling pathway relationship: part_of GO:0021921 ! regulation of cell proliferation in dorsal spinal cord [Term] id: GO:0021923 name: cell proliferation in hindbrain ventricular zone namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population in the hindbrain region that is adjacent to the ventricular cavity." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12593981, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021924 name: cell proliferation in external granule layer namespace: biological_process def: "The multiplication or reproduction of neuroblasts resulting in the expansion of a cell population in the external granule layer of the hindbrain. The external granule layer is the layer that originates from the rostral half of the rhombic lip in the first rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021534 ! cell proliferation in hindbrain [Term] id: GO:0021925 name: cerebellar Purkinje cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Purkinje cells. A Purkinje cell is an inhibitory GABAergic neuron found in the cerebellar cortex that projects to the deep cerebellar nuclei and brain stem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021926 name: Golgi cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to Golgi cells. A Golgi cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021927 name: deep nuclear neuron precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to deep nuclear neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021928 name: basket cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to basket cells. A cerebellar basket cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021929 name: stellate cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to stellate cells. A cerebellar stellate cell is an inhibitory GABAergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021923 ! cell proliferation in hindbrain ventricular zone [Term] id: GO:0021930 name: cerebellar granule cell precursor proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to granule cells. A granule cell is a glutamatergic interneuron found in the cerebellar cortex." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021931 name: rostral hindbrain neuronal precursor cell proliferation namespace: biological_process def: "The multiplication or reproduction of neuroblasts that will give rise to neurons of the lateral pontine nucleus and the locus ceruleus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021924 ! cell proliferation in external granule layer [Term] id: GO:0021932 name: hindbrain radial glia guided cell migration namespace: biological_process def: "The radially directed movement of a cell along radial glial cells in the hindbrain. Radial migration refers to a directed movement from the internal ventricular area to the outer surface of the hindbrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021933 name: radial glia guided migration of cerebellar granule cell namespace: biological_process def: "The inward migration of postmitotic granule cells along a radial glial cell from the external granule layer to the internal granule cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021934 name: hindbrain tangential cell migration namespace: biological_process def: "The migration of a cell in the hindbrain in which cells move orthogonal to the direction of radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hindbrain neurophilic migration" RELATED [PMID:15157725] is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021935 name: cerebellar granule cell precursor tangential migration namespace: biological_process def: "The early migration of granule cell precursors in which cells move orthogonal to the direction of radial migration and ultimately cover the superficial zone of the cerebellar primordium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021936 name: regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that modulates the frequency, rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0051960 ! regulation of nervous system development is_a: GO:2000177 ! regulation of neural precursor cell proliferation relationship: regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021937 name: cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation namespace: biological_process def: "The process that mediates the transfer of information from Purkinje cells to granule cell precursors resulting in an increase in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Purkinje cell-granule cell precursor cell signalling involved in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0021940 ! positive regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021938 name: smoothened signaling pathway involved in regulation of cerebellar granule cell precursor cell proliferation namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened in cerebellar granule cells that contributes to the regulation of proliferation of the cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "hedgehog signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in regulation of granule cell precursor cell proliferation" EXACT [GOC:bf, GOC:ecd] synonym: "smoothened signalling pathway in regulation of granule cell precursor cell proliferation" EXACT [] is_a: GO:0007224 ! smoothened signaling pathway is_a: GO:1905114 ! cell surface receptor signaling pathway involved in cell-cell signaling relationship: part_of GO:0021937 ! cerebellar Purkinje cell-granule cell precursor cell signaling involved in regulation of granule cell precursor cell proliferation [Term] id: GO:0021939 name: extracellular matrix-granule cell signaling involved in regulation of granule cell precursor proliferation namespace: biological_process def: "The process that mediates the transfer of information from the extracellular matrix to granule cell precursors resulting in a decrease in rate of granule cell precursor cell proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "extracellular matrix-granule cell signalling involved in regulation of granule cell precursor proliferation" EXACT [] is_a: GO:0035426 ! extracellular matrix-cell signaling relationship: part_of GO:0021941 ! negative regulation of cerebellar granule cell precursor proliferation [Term] id: GO:0021940 name: positive regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that activates or increases the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "activation of granule cell precursor proliferation" NARROW [] synonym: "stimulation of granule cell precursor proliferation" NARROW [] synonym: "up regulation of granule cell precursor proliferation" EXACT [] synonym: "up-regulation of granule cell precursor proliferation" EXACT [] synonym: "upregulation of granule cell precursor proliferation" EXACT [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:0051962 ! positive regulation of nervous system development is_a: GO:2000179 ! positive regulation of neural precursor cell proliferation relationship: positively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021941 name: negative regulation of cerebellar granule cell precursor proliferation namespace: biological_process def: "The process that stops, prevents or reduces the rate or extent of granule cell precursor proliferation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "down regulation of granule cell precursor proliferation" EXACT [] synonym: "down-regulation of granule cell precursor proliferation" EXACT [] synonym: "downregulation of granule cell precursor proliferation" EXACT [] synonym: "inhibition of granule cell precursor proliferation" NARROW [] is_a: GO:0021936 ! regulation of cerebellar granule cell precursor proliferation is_a: GO:0051961 ! negative regulation of nervous system development is_a: GO:2000178 ! negative regulation of neural precursor cell proliferation relationship: negatively_regulates GO:0021930 ! cerebellar granule cell precursor proliferation [Term] id: GO:0021942 name: radial glia guided migration of Purkinje cell namespace: biological_process def: "The migration of postmitotic a Purkinje cell along radial glial cells from the ventricular zone to the Purkinje cell layer." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021943 name: formation of radial glial scaffolds namespace: biological_process def: "The formation of scaffolds from a radial glial cell. The scaffolds are used as a substrate for the radial migration of cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "Bergmann fiber biosynthesis" RELATED [PMID:15157725] synonym: "Bergmann fiber formation" RELATED [PMID:15157725] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021944 name: neuronal-glial interaction involved in hindbrain glial-mediated radial cell migration namespace: biological_process def: "The changes in adhesion between a neuronal cell and a glial cell as a component of the process of hindbrain glial-mediated radial cell migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0098609 ! cell-cell adhesion relationship: part_of GO:0021932 ! hindbrain radial glia guided cell migration [Term] id: GO:0021945 name: positive regulation of cerebellar granule cell migration by calcium namespace: biological_process def: "The process that increases the extent of granule cell motility using intracellular calcium signaling mechanisms during radial migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "calcium-mediated activation of granule cell migration" NARROW [] synonym: "calcium-mediated positive regulation of granule cell migration" EXACT [GOC:dph, GOC:tb] synonym: "calcium-mediated stimulation of granule cell migration" NARROW [] synonym: "calcium-mediated up regulation of granule cell migration" EXACT [] synonym: "calcium-mediated up-regulation of granule cell migration" EXACT [] synonym: "calcium-mediated upregulation of granule cell migration" EXACT [] is_a: GO:0019722 ! calcium-mediated signaling is_a: GO:0030335 ! positive regulation of cell migration relationship: part_of GO:0021933 ! radial glia guided migration of cerebellar granule cell [Term] id: GO:0021946 name: deep nuclear neuron cell migration namespace: biological_process def: "The directed movement of a deep nuclear neuron from the ventricular zone to the deep hindbrain nuclei." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain [Term] id: GO:0021947 name: outward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from their ventrolateral origin to a rostrodorsal region of the cerebellar plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021948 name: inward migration of deep nuclear neurons namespace: biological_process def: "The directed movement of a deep nuclear neuron from the rostrodorsal region of the cerebellar plate to their final more ventral position." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0001764 ! neuron migration is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021946 ! deep nuclear neuron cell migration [Term] id: GO:0021949 name: brainstem precerebellar neuron precursor migration namespace: biological_process def: "The early migration of a precerebellar neuronal precursor in which a cell move from the rhombic lip, orthogonal to the direction of radial migration and ultimately reside in the brainstem." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. is_a: GO:0021934 ! hindbrain tangential cell migration [Term] id: GO:0021950 name: chemorepulsion involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that repel a precerebellar neuron as a component of the process of tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "negative chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050919 ! negative chemotaxis relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021951 name: chemoattraction involved in precerebellar neuron migration namespace: biological_process def: "The creation and reception of signals that guide a precerebellar neuron towards their signals, where this process is involved in tangential migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15157725] comment: This term was added by GO_REF:0000021. synonym: "positive chemotaxis involved in precerebellar neuron migration" EXACT [GOC:mah] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0021949 ! brainstem precerebellar neuron precursor migration [Term] id: GO:0021952 name: central nervous system projection neuron axonogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells in a different central nervous system region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "central nervous system axon tract development" NARROW [GOC:dph] is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021953 name: central nervous system neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron whose cell body resides in the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0021954 name: central nervous system neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron whose cell body is located in the central nervous system, from initial commitment of the cell to a neuronal fate, to the fully functional differentiated neuron." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048666 ! neuron development relationship: part_of GO:0021953 ! central nervous system neuron differentiation [Term] id: GO:0021955 name: central nervous system neuron axonogenesis namespace: biological_process def: "Generation of a long process from a neuron whose cell body resides in the central nervous system. The process carries efferent (outgoing) action potentials from the cell body towards target cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0007409 ! axonogenesis relationship: part_of GO:0021954 ! central nervous system neuron development [Term] id: GO:0021956 name: central nervous system interneuron axonogenesis namespace: biological_process def: "Generation of a long process that carries efferent (outgoing) action potentials from the cell body towards target cells from a neuron located in the central nervous system whose axons remain within a single brain region." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021955 ! central nervous system neuron axonogenesis [Term] id: GO:0021957 name: corticospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a pyramidal cell, that carries efferent (outgoing) action potentials from the cell body in cerebral cortex layer V towards target cells in the gray matter of the spinal cord. This axonal process is a member of those that make up the corticospinal tract." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal tract axonogenesis" EXACT [GOC:dph, PMID:9878731] synonym: "CST axonogenesis" EXACT [GOC:dph, PMID:9878731] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021958 name: gracilis tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the gracilis tract, a group of axons that are from neurons involved in proprioception from the lower trunk and lower limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Goll morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021959 name: cuneatus tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the dorsal root ganglion towards target cells in the medulla. This axonal process is a member of those that make up the cuneatus tract, a group of axons that are from neurons involved in proprioception from the upper trunk and upper limb." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:12867698] comment: This term was added by GO_REF:0000021. synonym: "tract of Burdach morphogenesis" EXACT [PMID:12867698] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021960 name: anterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in one half of the cerebral cortex towards target cells in the contralateral half. This axonal process is a member of those that make up the anterior commissure, a small midline fiber tract that lies at the anterior end of the corpus callosum." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021961 name: posterior commissure morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the midbrain towards target cells in the diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021962 name: vestibulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the vestibular nucleus of the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021963 name: spinothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the spinothalamic tract, one of the major routes of nociceptive signaling." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "dorsolateral tract of Lissauer morphogenesis" EXACT [] is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021964 name: rubrospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the red nucleus of the midbrain towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021965 name: spinal cord ventral commissure morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the spinal cord ventral commissure are generated and organized." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis relationship: part_of GO:0021510 ! spinal cord development [Term] id: GO:0021966 name: corticospinal neuron axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a neuron that is part of the corticospinal tract is directed from the cerebral cortex layer V to the spinal cord dorsal funiculus in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021957 ! corticospinal tract morphogenesis [Term] id: GO:0021967 name: corticospinal neuron axon guidance through the cerebral cortex namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed from its cell body in layer V through the cerebral cortex in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral cortex" NARROW [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021968 name: corticospinal neuron axon guidance through the internal capsule namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral cortex through the internal capsule in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the internal capsule" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021969 name: corticospinal neuron axon guidance through the cerebral peduncle namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the internal capsule through the cerebral peduncle in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the cerebral peduncle" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021970 name: corticospinal neuron axon guidance through the basilar pons namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the cerebral peduncle through the basilar pons in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the basilar pons" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021971 name: corticospinal neuron axon guidance through the medullary pyramid namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after exiting the basilar pons through the medullary pyramid in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through the medullary pyramid" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021972 name: corticospinal neuron axon guidance through spinal cord namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed after decussation through the spinal cord in response to a combination of attractive and repulsive cues." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. synonym: "corticospinal neuron axon pathfinding through spinal cord" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021973 name: corticospinal neuron axon decussation namespace: biological_process def: "The process in which the migration of an axon growth cone of a pyramidal cell that is part of the corticospinal tract is directed to cross the midline to the contralateral side." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:9878731] comment: This term was added by GO_REF:0000021. is_a: GO:0016199 ! axon midline choice point recognition relationship: part_of GO:0021966 ! corticospinal neuron axon guidance [Term] id: GO:0021974 name: trigeminothalamic tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in spinal cord towards target cells in the thalamus. This axonal process is a member of those that make up the trigeminothalamic tract, one of the major routes of nociceptive and temperature signaling from the face." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878937420] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021975 name: pons reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the pons towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021976 name: medulla reticulospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the medulla towards target cells in the spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021977 name: tectospinal tract morphogenesis namespace: biological_process def: "Generation of a long process of a CNS neuron, that carries efferent (outgoing) action potentials from the cell body in the superior colliculus of the midbrain towards target cells in the ventral spinal cord." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021952 ! central nervous system projection neuron axonogenesis [Term] id: GO:0021978 name: telencephalon regionalization namespace: biological_process def: "The regionalization process that creates areas within the forebrain that will direct the behavior of cell migration in differentiation as the telencephalon develops." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0003002 ! regionalization relationship: part_of GO:0021537 ! telencephalon development relationship: part_of GO:0021871 ! forebrain regionalization [Term] id: GO:0021979 name: hypothalamus cell differentiation namespace: biological_process def: "The differentiation of cells that will contribute to the structure and function of the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mgi_curators, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021854 ! hypothalamus development [Term] id: GO:0021980 name: subpallium cell migration namespace: biological_process def: "The orderly movement of cells from one site to another in the subpallium." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0021981 name: subpallium radially oriented migration namespace: biological_process def: "The migration of cells in the developing subpallium in which cells move from the ventricular and/or subventricular zone toward the surface of the brain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021980 ! subpallium cell migration [Term] id: GO:0021982 name: pineal gland development namespace: biological_process def: "The progression of the pineal gland over time from its initial formation until its mature state. The pineal gland is an endocrine gland that secretes melatonin and is involved in circadian rhythms." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epiphysis development" EXACT [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021983 name: pituitary gland development namespace: biological_process def: "The progression of the pituitary gland over time from its initial formation until its mature state. The pituitary gland is an endocrine gland that secretes hormones that regulate many other glands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "hypophysis development" RELATED [GOC:dph] is_a: GO:0048732 ! gland development relationship: part_of GO:0021536 ! diencephalon development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0021984 name: adenohypophysis development namespace: biological_process def: "The progression of the adenohypophysis over time from its initial formation until its mature state. The adenohypophysis is the anterior part of the pituitary. It secretes a variety of hormones and its function is regulated by the hypothalamus." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "adenophysis development" EXACT [] synonym: "anterior pituitary development" EXACT [] synonym: "anterior pituitary gland development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021985 name: neurohypophysis development namespace: biological_process def: "The progression of the neurohypophysis over time from its initial formation until its mature state. The neurohypophysis is the part of the pituitary gland that secretes hormones involved in blood pressure regulation." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neurophysis development" EXACT [] synonym: "posterior pituitary development" EXACT [] synonym: "posterior pituitary gland development" EXACT [] is_a: GO:0048732 ! gland development relationship: part_of GO:0021983 ! pituitary gland development [Term] id: GO:0021986 name: habenula development namespace: biological_process def: "The progression of the habenula over time from its initial formation until its mature state. The habenula is the group of nuclei that makes up the stalk of the pineal gland." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:9780721601465] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021538 ! epithalamus development [Term] id: GO:0021987 name: cerebral cortex development namespace: biological_process def: "The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "corticogenesis" NARROW [GOC:bf, PMID:25904839] synonym: "neocortex development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0021988 name: olfactory lobe development namespace: biological_process def: "The progression of the olfactory lobe over time from its initial formation until its mature state. The olfactory lobe is the area of the brain that process the neural inputs for the sense of smell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0021989 name: olfactory cortex development namespace: biological_process def: "The progression of the olfactory cortex over time from its initial formation until its mature state. The olfactory cortex is involved in the perception of smell. It receives input from the olfactory bulb and is responsible for the identification of odors." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021988 ! olfactory lobe development [Term] id: GO:0021990 name: neural plate formation namespace: biological_process def: "The formation of the flat, thickened layer of ectodermal cells known as the neural plate. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, ISBN:0878932437, ISBN:0878932585, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021991 name: neural plate thickening namespace: biological_process def: "The process of apical-basal elongation of individual ectodermal cells during the formation of the neural placode." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001839 ! neural plate morphogenesis [Term] id: GO:0021992 name: cell proliferation involved in neural plate elongation namespace: biological_process def: "The process of expansion of cell numbers in the neural plate due to cell division of progenitor cells preferentially in the rostrocaudal direction, resulting in the elongation of the tissue." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0021993 name: initiation of neural tube closure namespace: biological_process def: "The process in which closure points are established at multiple points and along the neural rostrocaudal axis." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021994 name: progression of neural tube closure namespace: biological_process def: "The process in which the neural folds are fused extending from the initial closure points." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021995 name: neuropore closure namespace: biological_process def: "The process of joining together the neural folds at either end of the neural tube." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001843 ! neural tube closure [Term] id: GO:0021996 name: lamina terminalis formation namespace: biological_process def: "The process in which the anterior-most portion of the neural axis is formed by closure of the anterior neuropore." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0021506 ! anterior neuropore closure [Term] id: GO:0021997 name: neural plate axis specification namespace: biological_process def: "The pattern specification process in which the axes of the nervous system are established." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification relationship: part_of GO:0001840 ! neural plate development relationship: part_of GO:0060896 ! neural plate pattern specification [Term] id: GO:0021998 name: neural plate mediolateral regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random mediolateral spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate mediolateral pattern formation" RELATED [GOC:dph] is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0021999 name: neural plate anterior/posterior regionalization namespace: biological_process def: "The process that regulates the coordinated growth and differentiation that establishes the non-random anterior-posterior spatial arrangement of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "neural plate anterior/posterior pattern formation" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern specification is_a: GO:0060897 ! neural plate regionalization [Term] id: GO:0022000 name: forebrain induction by the anterior neural ridge namespace: biological_process def: "The close range interaction of the anterior neural ridge to the caudal region of the neural plate that specifies the forebrain fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0031128 ! developmental induction relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022001 name: negative regulation of anterior neural cell fate commitment of the neural plate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "caudalization of neural plate" EXACT [] synonym: "down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "posteriorization" BROAD [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0051961 ! negative regulation of nervous system development relationship: part_of GO:0021999 ! neural plate anterior/posterior regionalization [Term] id: GO:0022002 name: negative regulation of anterior neural cell fate commitment of the neural plate by Wnt signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which a cell adopts an anterior neural cell fate, initiated by binding of Wnt protein to a receptor on the surface of the target cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of anterior neural cell fate commitment of the neural plate by Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "Wnt receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "Wnt receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "Wnt receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "Wnt receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0016055 ! Wnt signaling pathway is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate [Term] id: GO:0022003 name: negative regulation of anterior neural cell fate commitment of the neural plate by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals that stops, prevents or reduces the frequency or rate at which cell adopts an anterior neural cell fate, generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:tb] comment: This term was added by GO_REF:0000021. synonym: "fgf receptor signaling involved in down regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in down-regulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in downregulation of anterior neural cell fate of the neural plate" EXACT [] synonym: "fgf receptor signaling involved in inhibition of anterior neural cell fate of the neural plate" NARROW [] synonym: "fgf receptor signaling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [GOC:dph, GOC:tb] synonym: "fgf receptor signalling involved in negative regulation of anterior neural cell fate of the neural plate" EXACT [] is_a: GO:0022001 ! negative regulation of anterior neural cell fate commitment of the neural plate is_a: GO:0060825 ! fibroblast growth factor receptor signaling pathway involved in neural plate anterior/posterior pattern formation [Term] id: GO:0022004 name: midbrain-hindbrain boundary maturation during brain development namespace: biological_process def: "A developmental process occurring after the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022005 name: midbrain-hindbrain boundary maturation during neural plate development namespace: biological_process def: "A developmental process occurring before the brain has been specified along the neural axis that is required for the midbrain-hindbrain boundary to attain its fully functional state. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages. An organizing center at the boundary patterns the midbrain and hindbrain primordia of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15541513] comment: This term was added by GO_REF:0000021. synonym: "midbrain-hindbrain boundary maturation involved in neural plate development" RELATED [GOC:dph, GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0021732 ! midbrain-hindbrain boundary maturation [Term] id: GO:0022006 name: zona limitans intrathalamica formation namespace: biological_process def: "The formation of the narrow stripe of cells that lies between the prospective dorsal and ventral thalami. This boundary contains signals that pattern the prethalamic and thalamic territories of the future mid-diencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:11425897, PMID:16452095] comment: This term was added by GO_REF:0000021. synonym: "zli biosynthesis" EXACT [] synonym: "zli formation" EXACT [] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0022007 name: convergent extension involved in neural plate elongation namespace: biological_process def: "The process of directed cell movement in the neural plate resulting in tissue elongation via intercalation of adjacent cells in an epithelial sheet at the midline, leading to narrowing and lengthening of the neural plate." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:13679871, PMID:15806586] comment: This term was added by GO_REF:0000021. is_a: GO:0060027 ! convergent extension involved in gastrulation is_a: GO:0060029 ! convergent extension involved in organogenesis relationship: part_of GO:0014022 ! neural plate elongation [Term] id: GO:0022008 name: neurogenesis namespace: biological_process def: "Generation of cells within the nervous system." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "nervous system cell generation" EXACT systematic_synonym [] synonym: "neural cell differentiation" RELATED [GOC:BHF, GOC:dph] xref: Wikipedia:Neurogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0022009 name: central nervous system vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes in the central nervous system. The capillary endothelial cells in the brain are specialized to form the blood-brain barrier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0001570 ! vasculogenesis relationship: part_of GO:0014045 ! establishment of endothelial blood-brain barrier [Term] id: GO:0022010 name: central nervous system myelination namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of oligodendrocytes in the central nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "myelination in central nervous system" EXACT [] is_a: GO:0032291 ! axon ensheathment in central nervous system is_a: GO:0042552 ! myelination relationship: part_of GO:0014003 ! oligodendrocyte development [Term] id: GO:0022011 name: myelination in peripheral nervous system namespace: biological_process def: "The process in which neuronal axons and dendrites become coated with a segmented lipid-rich sheath (myelin) to enable faster and more energetically efficient conduction of electrical impulses. The sheath is formed by the cell membranes of Schwann cells in the peripheral nervous system. Adjacent myelin segments are separated by a non-myelinated stretch of axon called a node of Ranvier." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "peripheral nervous system myelination" EXACT [] is_a: GO:0032292 ! peripheral nervous system axon ensheathment is_a: GO:0042552 ! myelination relationship: part_of GO:0014044 ! Schwann cell development [Term] id: GO:0022012 name: subpallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of subpallium cells in the forebrain, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021544 ! subpallium development [Term] id: GO:0022013 name: pallium cell proliferation in forebrain namespace: biological_process def: "The multiplication or reproduction of pallium cells in the forebrain, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021846 ! cell proliferation in forebrain relationship: part_of GO:0021543 ! pallium development [Term] id: GO:0022014 name: obsolete radial glial cell division in subpallium namespace: biological_process def: "OBSOLETE. The division of a radial glial cell in the subpallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was obsoleted because it represents a GO-CAM model. is_obsolete: true [Term] id: GO:0022015 name: radial glial cell division in pallium namespace: biological_process def: "The division of a radial glial cell in the pallium. A radial glial cell is a precursor cell that gives rise to neurons and astrocytes." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0051301 ! cell division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022016 name: pallium glioblast division namespace: biological_process def: "The division of a glioblast in the pallium. A glioblast is a dividing precursor cell that gives rise to glial cells." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "glioblast cell division in pallium" EXACT [GOC:curators] is_a: GO:0048860 ! glioblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022017 name: neuroblast division in pallium namespace: biological_process def: "The division of neuroblasts in the pallium. Neuroblasts are precursor cells that give rise to neurons." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021873 ! forebrain neuroblast division relationship: part_of GO:0022013 ! pallium cell proliferation in forebrain [Term] id: GO:0022018 name: lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022019 name: dorsal lateral ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of dorsal lateral ganglionic eminence cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain relationship: part_of GO:0022018 ! lateral ganglionic eminence cell proliferation [Term] id: GO:0022020 name: medial ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of medial ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022021 name: caudal ganglionic eminence cell proliferation namespace: biological_process def: "The multiplication or reproduction of caudal ganglionic eminence cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022022 name: septal cell proliferation namespace: biological_process def: "The multiplication or reproduction of septal cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "septum cell proliferation" EXACT [] is_a: GO:0022012 ! subpallium cell proliferation in forebrain [Term] id: GO:0022023 name: radial glial cell fate commitment in forebrain namespace: biological_process def: "The process in which the developmental fate of a cell becomes restricted such that it will develop into a radial glial cell in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021781 ! glial cell fate commitment is_a: GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain relationship: part_of GO:0021861 ! forebrain radial glial cell differentiation [Term] id: GO:0022024 name: BMP signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, which contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "BMP signalling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signaling pathway involved in forebrain neuron fate commitment" EXACT [] synonym: "bone morphogenetic protein signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0021882 ! regulation of transcription from RNA polymerase II promoter involved in forebrain neuron fate commitment is_a: GO:0030509 ! BMP signaling pathway [Term] id: GO:0022025 name: leukemia inhibitory factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "Any series of molecular signals initiated by the binding of leukemia inhibitory factor to a receptor on the surface of the target cell, that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, GOC:signaling] comment: This term was added by GO_REF:0000021. synonym: "leukemia inhibitory factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0048861 ! leukemia inhibitory factor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022026 name: epidermal growth factor signaling pathway involved in forebrain neuron fate commitment namespace: biological_process def: "The series of molecular signals generated as a consequence of a epidermal growth factor receptor binding to one of its physiological ligands that contributes to the commitment of a neuroblast to a neuronal fate. The neuron will reside in the forebrain." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "epidermal growth factor signalling pathway involved in forebrain neuron fate commitment" EXACT [] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway relationship: part_of GO:0021898 ! commitment of multipotent stem cells to neuronal lineage in forebrain [Term] id: GO:0022027 name: interkinetic nuclear migration namespace: biological_process def: "The movement of the nucleus of the ventricular zone cell between the apical and the basal zone surfaces. Mitosis occurs when the nucleus is near the apical surface, that is, the lumen of the ventricle." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0021846 ! cell proliferation in forebrain [Term] id: GO:0022028 name: tangential migration from the subventricular zone to the olfactory bulb namespace: biological_process def: "The migration of cells in the telencephalon from the subventricular zone to the olfactory bulb in which cells move orthogonally to the direction of radial migration and do not use radial glial cell processes as substrates for migration." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "rostral migratory stream migration" EXACT [] is_a: GO:0022029 ! telencephalon cell migration relationship: part_of GO:0021772 ! olfactory bulb development [Term] id: GO:0022029 name: telencephalon cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another at least one of which is located in the telencephalon." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0021885 ! forebrain cell migration relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022030 name: telencephalon glial cell migration namespace: biological_process def: "The orderly movement of glial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0008347 ! glial cell migration is_a: GO:0022029 ! telencephalon cell migration [Term] id: GO:0022031 name: telencephalon astrocyte cell migration namespace: biological_process def: "The orderly movement of an astrocyte cell through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration is_a: GO:0043615 ! astrocyte cell migration [Term] id: GO:0022032 name: telencephalon oligodendrocyte cell migration namespace: biological_process def: "The multiplication or reproduction of telencephalon oligodendrocyte cells, resulting in the expansion of a cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022033 name: telencephalon microglial cell migration namespace: biological_process def: "The orderly movement of microglial cells through the telencephalon." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0022030 ! telencephalon glial cell migration [Term] id: GO:0022034 name: rhombomere cell proliferation namespace: biological_process def: "The multiplication or reproduction of rhombomere cells, resulting in the expansion of the cell population." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0061351 ! neural precursor cell proliferation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022035 name: rhombomere cell migration namespace: biological_process def: "The movement of a cell within a rhombomere. This process is known to occur as an early step in the generation of anatomical structure from a rhombomere." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06, PMID:15629700] comment: This term was added by GO_REF:0000021. is_a: GO:0021535 ! cell migration in hindbrain relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022036 name: rhombomere cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a rhombomere cell." [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0021546 ! rhombomere development [Term] id: GO:0022037 name: metencephalon development namespace: biological_process def: "The process whose specific outcome is the progression of the metencephalon over time, from its formation to the mature structure." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0030902 ! hindbrain development [Term] id: GO:0022038 name: corpus callosum development namespace: biological_process def: "The process whose specific outcome is the progression of the corpus callosum over time, from its formation to the mature structure. The corpus callosum is a thick bundle of nerve fibers comprising a commissural plate connecting the two cerebral hemispheres. It consists of contralateral axon projections that provide communication between the right and left cerebral hemispheres." [GO_REF:0000021, GOC:cls, GOC:curators, GOC:dgh, GOC:dph, GOC:jid, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0021537 ! telencephalon development [Term] id: GO:0022400 name: regulation of rhodopsin mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin-mediated signaling." [GOC:mah] synonym: "regulation of rhodopsin mediated signalling" EXACT [] is_a: GO:0008277 ! regulation of G protein-coupled receptor signaling pathway is_a: GO:0032101 ! regulation of response to external stimulus relationship: regulates GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0022401 name: negative adaptation of signaling pathway namespace: biological_process def: "The negative regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:isa_complete] synonym: "negative adaptation of signal transduction pathway" EXACT [] synonym: "negative adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0022402 name: cell cycle process namespace: biological_process def: "The cellular process that ensures successive accurate and complete genome replication and chromosome segregation." [GOC:isa_complete, GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0009987 ! cellular process relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0022403 name: cell cycle phase namespace: biological_process def: "One of the distinct periods or stages into which the cell cycle is divided. Each phase is characterized by the occurrence of specific biochemical and morphological events." [GOC:mtg_cell_cycle] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022404 name: molting cycle process namespace: biological_process def: "A multicellular organismal process involved in the periodic casting off and regeneration of an outer covering of cuticle, feathers, hair, horns, skin." [GOC:isa_complete] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0042303 ! molting cycle [Term] id: GO:0022405 name: hair cycle process namespace: biological_process def: "A multicellular organismal process involved in the cyclical phases of growth (anagen), regression (catagen), quiescence (telogen), and shedding (exogen) in the life of a hair; one of the collection or mass of filaments growing from the skin of an animal, and forming a covering for a part of the head or for any part or the whole of the body." [GOC:isa_complete] is_a: GO:0022404 ! molting cycle process relationship: part_of GO:0042633 ! hair cycle [Term] id: GO:0022406 name: membrane docking namespace: biological_process def: "The initial attachment of a membrane or protein to a target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete, PMID:27875684] subset: goslim_pir synonym: "membrane docking" EXACT [] is_a: GO:0009987 ! cellular process [Term] id: GO:0022407 name: regulation of cell-cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell." [GOC:isa_complete] is_a: GO:0030155 ! regulation of cell adhesion relationship: regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022408 name: negative regulation of cell-cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "down regulation of cell-cell adhesion" EXACT [] synonym: "down-regulation of cell-cell adhesion" EXACT [] synonym: "downregulation of cell-cell adhesion" EXACT [] synonym: "inhibition of cell-cell adhesion" NARROW [] is_a: GO:0007162 ! negative regulation of cell adhesion is_a: GO:0022407 ! regulation of cell-cell adhesion relationship: negatively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022409 name: positive regulation of cell-cell adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to another cell." [GOC:isa_complete] synonym: "activation of cell-cell adhesion" NARROW [] synonym: "stimulation of cell-cell adhesion" NARROW [] synonym: "up regulation of cell-cell adhesion" EXACT [] synonym: "up-regulation of cell-cell adhesion" EXACT [] synonym: "upregulation of cell-cell adhesion" EXACT [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0045785 ! positive regulation of cell adhesion relationship: positively_regulates GO:0098609 ! cell-cell adhesion [Term] id: GO:0022410 name: circadian sleep/wake cycle process namespace: biological_process def: "A behavioral process involved in the cycle from wakefulness through an orderly succession of sleep states and stages that occurs on an approximately 24 hour rhythm." [GOC:isa_complete] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0042745 ! circadian sleep/wake cycle [Term] id: GO:0022411 name: cellular component disassembly namespace: biological_process alt_id: GO:0071845 def: "A cellular process that results in the breakdown of a cellular component." [GOC:isa_complete] subset: goslim_pir synonym: "cell structure disassembly" EXACT [] synonym: "cellular component disassembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0022412 name: cellular process involved in reproduction in multicellular organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a multicellular organism." [GOC:isa_complete] synonym: "reproductive cellular process in multicellular organism" EXACT [GOC:curators] is_a: GO:0009987 ! cellular process is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032504 ! multicellular organism reproduction [Term] id: GO:0022413 name: reproductive process in single-celled organism namespace: biological_process def: "A process, occurring at the cellular level, that is involved in the reproductive function of a single-celled organism." [GOC:isa_complete] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0032505 ! reproduction of a single-celled organism [Term] id: GO:0022414 name: reproductive process namespace: biological_process alt_id: GO:0044702 def: "A biological process that directly contributes to the process of producing new individuals by one or two organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:dph, GOC:isa_complete] synonym: "single organism reproductive process" RELATED [] is_a: GO:0008150 ! biological_process relationship: part_of GO:0000003 ! reproduction [Term] id: GO:0022416 name: chaeta development namespace: biological_process def: "The process whose specific outcome is the progression of a chaeta over time, from its formation to the mature structure. A chaeta is a sensory multicellular cuticular outgrowth of a specifically differentiated cell." [FBbt:00005177, GOC:bf, GOC:cjm, GOC:dos, GOC:isa_complete] synonym: "bristle development" NARROW [GOC:bf, GOC:dos] is_a: GO:0007423 ! sensory organ development [Term] id: GO:0022417 name: protein maturation by protein folding namespace: biological_process def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure that results in the attainment of the full functional capacity of a protein." [GOC:isa_complete] is_a: GO:0006457 ! protein folding is_a: GO:0051604 ! protein maturation [Term] id: GO:0022600 name: digestive system process namespace: biological_process def: "A physical, chemical, or biochemical process carried out by living organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, GOC:jid, GOC:mtg_cardio] is_a: GO:0003008 ! system process relationship: part_of GO:0007586 ! digestion [Term] id: GO:0022601 name: menstrual cycle phase namespace: biological_process def: "The progression of physiological phases, occurring in the endometrium during the menstrual cycle that recur at regular intervals during the reproductive years. The menstrual cycle is an ovulation cycle where the endometrium is shed if pregnancy does not occur." [GOC:dph, GOC:isa_complete, GOC:jid] subset: gocheck_do_not_annotate is_a: GO:0044848 ! biological phase [Term] id: GO:0022602 name: ovulation cycle process namespace: biological_process def: "A process involved in the sexual cycle seen in females, often with physiologic changes in the endometrium that recur at regular intervals during the reproductive years." [GOC:isa_complete] synonym: "estrous cycle process" RELATED [] synonym: "menstrual cycle process" RELATED [] is_a: GO:0022414 ! reproductive process is_a: GO:0048511 ! rhythmic process relationship: part_of GO:0042698 ! ovulation cycle [Term] id: GO:0022603 name: regulation of anatomical structure morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anatomical structure morphogenesis." [GOC:mah] synonym: "regulation of morphogenesis" EXACT [] is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0022604 name: regulation of cell morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell morphogenesis. Cell morphogenesis is the developmental process in which the shape of a cell is generated and organized." [GOC:isa_complete] synonym: "negative regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cell shape and cell size" RELATED [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0000902 ! cell morphogenesis [Term] id: GO:0022605 name: mammalian oogenesis stage namespace: biological_process def: "A reproductive process that is a step in the formation and maturation of an ovum or female gamete from a primordial female germ cell." [GOC:isa_complete, GOC:mtg_sensu] synonym: "mammalian oogenesis process" EXACT [] is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0022606 name: establishment of proximal/distal cell polarity namespace: biological_process def: "The specification and formation of the polarity of a cell along its proximal/distal axis." [GOC:isa_complete] is_a: GO:0061162 ! establishment of monopolar cell polarity [Term] id: GO:0022607 name: cellular component assembly namespace: biological_process alt_id: GO:0071844 def: "The aggregation, arrangement and bonding together of a cellular component." [GOC:isa_complete] subset: goslim_chembl subset: goslim_generic subset: goslim_pir synonym: "cell structure assembly" EXACT [] synonym: "cellular component assembly at cellular level" EXACT [] is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0044085 ! cellular component biogenesis [Term] id: GO:0022608 name: multicellular organism adhesion namespace: biological_process def: "The attachment of a multicellular organism to a substrate or other organism." [GOC:isa_complete] is_a: GO:0022610 ! biological adhesion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0022609 name: multicellular organism adhesion to substrate namespace: biological_process def: "The attachment of a multicellular organism to a surface or material." [GOC:isa_complete] is_a: GO:0022608 ! multicellular organism adhesion [Term] id: GO:0022610 name: biological adhesion namespace: biological_process def: "The attachment of a cell or organism to a substrate, another cell, or other organism. Biological adhesion includes intracellular attachment between membrane regions." [GOC:isa_complete] subset: goslim_pir is_a: GO:0008150 ! biological_process [Term] id: GO:0022611 name: dormancy process namespace: biological_process def: "A developmental process in which dormancy (sometimes called a dormant state) is induced, maintained or broken. Dormancy is a suspension of most physiological activity and growth that can be reactivated." [GOC:isa_complete, GOC:PO_curators, PO_REF:00009] comment: In plants and animals, dormancy may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. In plants, dormancy may involve the formation of dormant buds, and may be preceded by the senescence of plant parts such as leaves in woody plants or most of the shoot system in herbaceous perennials. The exit from dormancy in vascular plants is marked by resumed growth of buds and/or growth of vascular cambium. synonym: "multicellular organism dormancy process" NARROW [] synonym: "spore dormancy process" NARROW [GOC:PO_curators] is_a: GO:0032502 ! developmental process [Term] id: GO:0022612 name: gland morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a gland are generated and organized." [GOC:isa_complete] is_a: GO:0009887 ! animal organ morphogenesis relationship: part_of GO:0048732 ! gland development [Term] id: GO:0022613 name: ribonucleoprotein complex biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a complex containing RNA and proteins. Includes the biosynthesis of the constituent RNA and protein molecules, and those macromolecular modifications that are involved in synthesis or assembly of the ribonucleoprotein complex." [GOC:isa_complete, GOC:mah] synonym: "ribonucleoprotein complex biogenesis and assembly" EXACT [GOC:mah] synonym: "RNA-protein complex biogenesis" EXACT [GOC:mah] is_a: GO:0044085 ! cellular component biogenesis [Term] id: GO:0022614 name: membrane to membrane docking namespace: biological_process def: "The initial attachment of a membrane to a target membrane, mediated by proteins protruding from the two membranes. Docking requires only that the membranes come close enough for the proteins to interact and adhere." [GOC:isa_complete] synonym: "membrane-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022615 name: protein to membrane docking namespace: biological_process def: "The initial attachment of a protein to a target membrane, mediated by a proteins protruding from the target membrane. Docking requires only that the proteins come close enough to interact and adhere." [GOC:isa_complete] synonym: "protein-membrane docking" EXACT [] is_a: GO:0022406 ! membrane docking [Term] id: GO:0022616 name: DNA strand elongation namespace: biological_process def: "The DNA metabolic process in which an existing DNA strand is extended by activities including the addition of nucleotides to the 3' end of the strand." [GOC:isa_complete, GOC:mah] comment: Changed definition https://github.com/geneontology/go-ontology/issues/12633 is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0022617 name: extracellular matrix disassembly namespace: biological_process def: "A process that results in the breakdown of the extracellular matrix." [GOC:jid] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0030198 ! extracellular matrix organization [Term] id: GO:0022618 name: ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and RNA molecules to form a ribonucleoprotein complex." [GOC:jl] subset: goslim_chembl subset: goslim_generic synonym: "protein-RNA complex assembly" EXACT [] synonym: "RNA-protein complex assembly" EXACT [] synonym: "RNP complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization relationship: part_of GO:0022613 ! ribonucleoprotein complex biogenesis [Term] id: GO:0022619 name: generative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a generative cell. The generative cell gives rise to the sperm cells in the male gametophyte." [GOC:isa_complete] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022620 name: vegetative cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a vegetative cell. The vegetative cell is gives rise to the pollen tube." [GOC:isa_complete] synonym: "tube cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0055046 ! microgametogenesis [Term] id: GO:0022622 name: root system development namespace: biological_process def: "The process whose specific outcome is the progression of the root system over time, from its formation to the mature structure." [GOC:isa_complete] is_a: GO:0048731 ! system development [Term] id: GO:0022623 name: proteasome-activating nucleotidase complex namespace: cellular_component def: "A homohexameric complex that recognizes and unfolds core proteasome substrate proteins, and translocates them to the core complex in an ATP dependent manner." [GOC:bf, GOC:mtg_sensu, PMID:19363223, PMID:19481528] synonym: "PAN" EXACT [PMID:19363223, PMID:19481528] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0022624 name: proteasome accessory complex namespace: cellular_component def: "A protein complex, that caps one or both ends of the proteasome core complex and regulates entry into, or exit from, the proteasome core complex." [GOC:mtg_sensu] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0022625 name: cytosolic large ribosomal subunit namespace: cellular_component alt_id: GO:0005842 alt_id: GO:0009282 alt_id: GO:0030498 alt_id: GO:0030872 def: "The large subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "50S ribosomal subunit" NARROW [] synonym: "60S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal LSU" NARROW [] synonym: "prokaryotic large ribosomal subunit" NARROW [] is_a: GO:0015934 ! large ribosomal subunit is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022626 name: cytosolic ribosome namespace: cellular_component alt_id: GO:0005830 alt_id: GO:0009281 alt_id: GO:0030871 def: "A ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "70S ribosome" NARROW [] synonym: "80S ribosome" NARROW [] is_a: GO:0005840 ! ribosome is_a: GO:0044445 ! cytosolic part [Term] id: GO:0022627 name: cytosolic small ribosomal subunit namespace: cellular_component alt_id: GO:0005843 alt_id: GO:0009283 alt_id: GO:0030499 alt_id: GO:0030873 def: "The small subunit of a ribosome located in the cytosol." [GOC:mtg_sensu] synonym: "30S ribosomal subunit" NARROW [] synonym: "40S ribosomal subunit" NARROW [] synonym: "eukaryotic ribosomal SSU" NARROW [] synonym: "prokaryotic small ribosomal subunit" NARROW [] is_a: GO:0015935 ! small ribosomal subunit is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0022626 ! cytosolic ribosome [Term] id: GO:0022628 name: chloroplast large ribosomal subunit namespace: cellular_component def: "The large subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal large subunit complex" EXACT [] synonym: "chloroplast ribosomal LSU complex" EXACT [] is_a: GO:0000311 ! plastid large ribosomal subunit is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022629 name: chloroplast small ribosomal subunit namespace: cellular_component def: "The small subunit of a ribosome contained within a chloroplast." [GOC:mtg_sensu] synonym: "chloroplast ribosomal small subunit complex" EXACT [] synonym: "chloroplast ribosomal SSU complex" EXACT [] is_a: GO:0000312 ! plastid small ribosomal subunit is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0043253 ! chloroplast ribosome [Term] id: GO:0022803 name: passive transmembrane transporter activity namespace: molecular_function alt_id: GO:0022814 def: "Enables the transfer of a single solute from one side of a membrane to the other by a mechanism involving conformational change, either by facilitated diffusion or in a membrane potential dependent process if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "facilitated diffusion" RELATED [] synonym: "porters" BROAD [] synonym: "uniporter activity z" NARROW [] xref: reactome:R-HSA-429767 "Passive I- efflux mediated by SMCT1" xref: Wikipedia:Facilitated_diffusion is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022804 name: active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a specific substance or related group of substances from one side of a membrane to the other, up the solute's concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] synonym: "active carrier activity" EXACT [] synonym: "carrier activity" EXACT [] synonym: "permease activity" EXACT [] synonym: "pump activity" EXACT [] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022809 name: mobile ion carrier activity namespace: molecular_function def: "Small molecule produced by bacteria that carries an ion across the membrane by enclosing the ion and travelling with the ion across the membrane. It does not form a fully open pore across the membrane." [GOC:mtg_transport, GOC:pr, ISBN:0815340729] synonym: "ionophore" BROAD [] is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0022810 name: membrane potential driven uniporter activity namespace: molecular_function def: "Enables the active transport of a solute across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] synonym: "porter" BROAD [] is_a: GO:0015292 ! uniporter activity [Term] id: GO:0022815 name: obsolete large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. synonym: "large uncharged polar molecule transmembrane transporter activity" EXACT [] is_obsolete: true replaced_by: GO:0022857 [Term] id: GO:0022818 name: sodium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a sodium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity [Term] id: GO:0022819 name: potassium ion uniporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism involving conformational change, where energy for active transport is derived from membrane potential if the solute is charged." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0022810 ! membrane potential driven uniporter activity [Term] id: GO:0022821 name: potassium ion antiporter activity namespace: molecular_function def: "Catalysis of the active transport of a potassium ion across a membrane by a mechanism whereby two or more species are transported in opposite directions in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0022824 name: transmitter-gated ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of an ion by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionotropic neurotransmitter receptor activity" NARROW [GOC:bf, GOC:sart] is_a: GO:0005230 ! extracellular ligand-gated ion channel activity is_a: GO:0022835 ! transmitter-gated channel activity [Term] id: GO:0022825 name: obsolete copper-exporting ATPase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was a placeholder during work on transporter terms, and was not defined. synonym: "copper-exporting ATPase activity" EXACT [] is_obsolete: true replaced_by: GO:0043682 [Term] id: GO:0022828 name: phosphorylation-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to phosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022829 name: wide pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a large pore, un-gated channel. Examples include gap junctions, which transport substances from one cell to another; and porins which transport substances in and out of bacteria, mitochondria and chloroplasts." [GOC:mtg_transport, ISBN:0815340729] synonym: "gap junction activity" NARROW [] synonym: "non-gated, wide pore channel activity" EXACT [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022831 name: narrow pore, gated channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that opens in response to a particular stimulus." [GOC:mtg_transport, ISBN:0815340729] synonym: "ion channels" RELATED [] xref: Wikipedia:Ion_channels is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022832 name: voltage-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022834 name: ligand-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022835 name: transmitter-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens when a specific neurotransmitter has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] synonym: "extracellular substance gated channel activity" EXACT [] synonym: "neurotransmitter-gated channel activity" EXACT [] is_a: GO:0022834 ! ligand-gated channel activity is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0022836 name: gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific stimulus." [GOC:mtg_transport] is_a: GO:0015267 ! channel activity [Term] id: GO:0022839 name: ion gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to a specific ion stimulus." [GOC:mtg_transport] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022840 name: leak channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022842 ! narrow pore channel activity [Term] id: GO:0022841 name: potassium ion leak channel activity namespace: molecular_function def: "Enables the transport of a potassium ion across a membrane via a narrow pore channel that is open even in an unstimulated or 'resting' state." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022840 ! leak channel activity [Term] id: GO:0022842 name: narrow pore channel activity namespace: molecular_function def: "Enables the transport of a solute across a membrane via a narrow pore channel that may be gated or ungated." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015267 ! channel activity [Term] id: GO:0022843 name: voltage-gated cation channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a cation by a voltage-gated channel. A cation is a positively charged ion. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [GOC:mtg_transport, ISBN:0815340729] xref: reactome:R-HSA-2534378 "Hv1 Mediated H+ Permeability" xref: reactome:R-HSA-6788999 "HV1-mediated H+ transfer" is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0022848 name: acetylcholine-gated cation-selective channel activity namespace: molecular_function alt_id: GO:0004889 alt_id: GO:0016904 def: "Selectively enables the transmembrane transfer of a cation by a channel that opens upon binding acetylcholine." [GOC:mah, PMID:2466967] synonym: "acetylcholine-activated cation-selective channel activity" EXACT [] synonym: "acetylcholine-gated cation channel activity" EXACT [] synonym: "iontropic acetylcholine receptor activity" EXACT [] synonym: "nAChR" EXACT [] synonym: "nicotinergic acetylcholine receptor activity" EXACT [] synonym: "nicotinic acetylcholine-activated cation-selective channel activity" EXACT [GOC:bf] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity is_a: GO:1904315 ! transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential [Term] id: GO:0022849 name: glutamate-gated calcium ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0004970 ! ionotropic glutamate receptor activity is_a: GO:0099604 ! ligand-gated calcium channel activity [Term] id: GO:0022850 name: serotonin-gated cation-selective channel activity namespace: molecular_function alt_id: GO:0005232 def: "Enables the transmembrane transfer of a cation by a channel that opens when serotonin has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'G protein-coupled serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" NARROW [] synonym: "serotonin-activated cation-selective channel activity" EXACT [] synonym: "serotonin-gated cation channel activity" NARROW [] xref: reactome:R-HSA-975311 "HTR3 pentamer:5HT transports Na+,K+, and Ca2+" is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099094 ! ligand-gated cation channel activity [Term] id: GO:0022851 name: GABA-gated chloride ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when GABA has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0016917 ! GABA receptor activity is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0022852 name: glycine-gated chloride ion channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a chloride ion by a channel that opens when glycine has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022824 ! transmitter-gated ion channel activity is_a: GO:0099095 ! ligand-gated anion channel activity [Term] id: GO:0022853 name: active ion transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of an ion from one side of a membrane to the other up the solute's concentration gradient. This is carried out by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0022854 name: obsolete active large uncharged polar molecule transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a large uncharged polar molecule from one side of the membrane to the other, up the solute's concentration gradient, by binding the solute and undergoing a series of conformational changes. Transport works equally well in either direction." [GOC:mtg_transport, ISBN:0815340729] comment: This term was made obsolete because 'large uncharged polar molecule' is not a useful chemical grouping term. synonym: "active large uncharged polar molecule transmembrane transporter activity" EXACT [] is_obsolete: true replaced_by: GO:0022804 [Term] id: GO:0022855 name: protein-N(PI)-phosphohistidine-glucose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + glucose(out) = protein histidine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "glucose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022856 name: protein-N(PI)-phosphohistidine-sorbitol phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbitol(out) = protein histidine + sorbitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015576 ! sorbitol transmembrane transporter activity [Term] id: GO:0022857 name: transmembrane transporter activity namespace: molecular_function alt_id: GO:0005386 alt_id: GO:0015563 alt_id: GO:0015646 alt_id: GO:0022891 alt_id: GO:0022892 def: "Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other." [GOC:jid, GOC:mtg_transport, ISBN:0815340729] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "substrate-specific transmembrane transporter activity" RELATED [] synonym: "substrate-specific transporter activity" NARROW [] synonym: "uptake permease activity" RELATED [] synonym: "uptake transmembrane transporter activity" RELATED [] xref: reactome:R-HSA-1236947 "Egress of internalized antigen to the cytosol via sec61" xref: reactome:R-HSA-429036 "SLC2A9 transports Fru, Glc, urate" xref: reactome:R-HSA-5671707 "Fe3+ dissociates from SLC22A17:LCN2:2,5DHBA" xref: reactome:R-HSA-6784434 "An unknown carrier transports cytosolic glyoxylate to the peroxisome" xref: reactome:R-HSA-6784436 "An unknown carrier transports mitochondrial glyoxylate to the cytosol" is_a: GO:0005215 ! transporter activity [Term] id: GO:0022858 name: alanine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of alanine from one side of a membrane to the other. Alanine is 2-aminopropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0022859 name: dephosphorylation-gated channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a solute by a channel that opens in response to dephosphorylation of one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022836 ! gated channel activity [Term] id: GO:0022865 name: obsolete transmembrane electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables electron flow across a biological membrane, from donors localized on one side of the membrane to acceptors localized on the other side. These systems contribute to or subtract from the membrane potential, depending on the direction of electron flow. They are therefore important to cellular energetics." [GOC:mtg_transport, ISBN:0815340729, TC:5] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. xref: TC:5 is_obsolete: true [Term] id: GO:0022866 name: obsolete transmembrane 1-electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables transfer of one electron across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.B] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. synonym: "transmembrane one-electron transfer carrier" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0022867 name: obsolete transmembrane 2-electron transfer carrier namespace: molecular_function def: "OBSOLETE. Enables transfer of two electrons across a membrane." [GOC:mtg_transport, ISBN:0815340729, TC:5.A] comment: The reason for obsoletion is that the term does not represent a molecular function but rather a process. synonym: "transmembrane two-electron transfer carrier" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0022869 name: protein-N(PI)-phosphohistidine-lactose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + lactose(out) = protein histidine + lactose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "lactose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015155 ! lactose transmembrane transporter activity [Term] id: GO:0022870 name: protein-N(PI)-phosphohistidine-mannose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannose(out) = protein histidine + mannose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015578 ! mannose transmembrane transporter activity [Term] id: GO:0022871 name: protein-N(PI)-phosphohistidine-sorbose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sorbose(out) = protein histidine + sorbose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sorbose PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019194 ! sorbose transmembrane transporter activity [Term] id: GO:0022872 name: protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + mannitol(out) = protein histidine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "mannitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015575 ! mannitol transmembrane transporter activity [Term] id: GO:0022873 name: protein-N(PI)-phosphohistidine-maltose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + maltose(out) = protein histidine + maltose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "maltose PTS transporter activity" EXACT [] is_a: GO:0005363 ! maltose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022874 name: protein-N(PI)-phosphohistidine-cellobiose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + cellobiose(out) = protein histidine + cellobiose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "cellobiose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019191 ! cellobiose transmembrane transporter activity [Term] id: GO:0022875 name: protein-N(PI)-phosphohistidine-galactitol phosphotransferase system transmembrane transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactitol(out) = protein histidine + galactitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactitol PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015577 ! galactitol transmembrane transporter activity [Term] id: GO:0022876 name: protein-N(PI)-phosphohistidine-galactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + galactosamine(out) = protein histidine + galactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "galactosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0019196 ! galactosamine transmembrane transporter activity [Term] id: GO:0022877 name: protein-N(PI)-phosphohistidine-fructose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + fructose(out) = protein histidine + fructose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "fructose PTS transporter activity" EXACT [] is_a: GO:0005353 ! fructose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022878 name: protein-N(PI)-phosphohistidine-sucrose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sucrose(out) = protein histidine + sucrose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "sucrose PTS transporter activity" EXACT [] xref: MetaCyc:SUCROSEPHOSPHO-RXN is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity [Term] id: GO:0022879 name: protein-N(PI)-phosphohistidine-trehalose phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + trehalose(out) = protein histidine + trehalose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "trehalose PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022880 name: protein-N(PI)-phosphohistidine-N-acetylglucosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylglucosamine(out) = protein histidine + N-acetylglucosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylglucosamine PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015572 ! N-acetylglucosamine transmembrane transporter activity is_a: GO:0015574 ! trehalose transmembrane transporter activity [Term] id: GO:0022881 name: protein-N(PI)-phosphohistidine-N-acetylgalactosamine phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetylgalactosamine(out) = protein histidine + N-acetylgalactosamine phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "N-acetylgalactosamine PTS transporter activity" EXACT [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015571 ! N-acetylgalactosamine transmembrane transporter activity [Term] id: GO:0022882 name: protein-N(PI)-phosphohistidine-beta-glucoside phosphotransferase system transporter activity namespace: molecular_function def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + beta-glucoside(out) = protein histidine + beta-glucoside phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [GOC:mtg_transport, ISBN:0815340729] synonym: "beta-glucoside PTS transporter activity" EXACT [] is_a: GO:0008982 ! protein-N(PI)-phosphohistidine-sugar phosphotransferase activity is_a: GO:0015573 ! beta-glucoside transmembrane transporter activity [Term] id: GO:0022883 name: zinc efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a zinc ion or zinc ions from the inside of the cell to the outside of the cell across a membrane." [GOC:mtg_transport, ISBN:0815340729] synonym: "zinc efflux permease activity" EXACT [] is_a: GO:0005385 ! zinc ion transmembrane transporter activity is_a: GO:0046583 ! cation efflux transmembrane transporter activity [Term] id: GO:0022884 name: macromolecule transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a macromolecule from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0022857 ! transmembrane transporter activity [Term] id: GO:0022885 name: bacteriocin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a bacteriocin from one side of a membrane to the other." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity is_a: GO:0042895 ! antibiotic transmembrane transporter activity [Term] id: GO:0022886 name: channel-forming ionophore activity namespace: molecular_function def: "Enables transport of a solute across a membrane. This kind of transporter interacts much more weakly with the solute than the carrier does. It is an aqueous pore that extends across the membrane. It may change from closed to open and back. It transports faster than a carrier. It is always passive." [GOC:mtg_transport, ISBN:0815340729] synonym: "ionophore activity" BROAD [] is_a: GO:0015267 ! channel activity [Term] id: GO:0022889 name: serine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of serine from one side of a membrane to the other. Serine is 2-amino-3-hydroxypropanoic acid." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0022890 name: inorganic cation transmembrane transporter activity namespace: molecular_function alt_id: GO:0015082 def: "Enables the transfer of inorganic cations from one side of a membrane to the other. Inorganic cations are atoms or small molecules with a positive charge that do not contain carbon in covalent linkage." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "di-, tri-valent inorganic cation transmembrane transporter activity" NARROW [GOC:mah] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0022893 name: low-affinity tryptophan transmembrane transporter activity namespace: molecular_function alt_id: GO:0015510 def: "Catalysis of the low-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] synonym: "low-affinity tryptophan permease activity" RELATED [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0022894 name: Intermediate conductance calcium-activated potassium channel activity namespace: molecular_function def: "Enables the transmembrane transfer of potassium by a channel with a unit conductance of 20 to 85 picoSiemens that opens in response to stimulus by internal calcium ions. Intermediate conductance calcium-activated potassium channels are more sensitive to calcium than are large conductance calcium-activated potassium channels. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, OMIM:602754] synonym: "IK calcium-activated potassium channel activity" EXACT [] synonym: "IK KCa channels" EXACT [] synonym: "intermdiate conductance KCa channels" EXACT [] is_a: GO:0015269 ! calcium-activated potassium channel activity [Term] id: GO:0022897 name: proton-dependent peptide secondary active transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of a peptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport] synonym: "hydrogen/oligopeptide symporter" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0022898 name: regulation of transmembrane transporter activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transmembrane transporter activity." [GOC:dph, GOC:mtg_cardio, GOC:mtg_transport] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0034762 ! regulation of transmembrane transport [Term] id: GO:0022900 name: electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport] subset: goslim_pir xref: Wikipedia:Electron_transport_chain is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0055114 ! oxidation-reduction process [Term] id: GO:0022904 name: respiratory electron transport chain namespace: biological_process def: "A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors to generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0716720094] synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] xref: Wikipedia:Electron_transfer is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0045333 ! cellular respiration [Term] id: GO:0023002 name: nuclear migration to embryo sac poles namespace: biological_process def: "Migration of the nuclei of the two-nucleate embryo sac to opposite poles of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to female gametophyte poles" EXACT [] synonym: "nuclear migration to megagametophyte poles" EXACT [] synonym: "nucleus migration to embryo sac poles" EXACT [] synonym: "nucleus migration to female gametophyte poles" EXACT [] synonym: "nucleus migration to megagametophyte poles" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023003 name: nuclear migration to the embryo sac center namespace: biological_process def: "Migration of one of the four nuclei at each pole of the eight-nucleate embryo sac, to the center of the cell." [GOC:jid, GOC:mtg_plant, ISBN:047186840X] synonym: "nuclear migration to the embryo sac centre" EXACT [] synonym: "nuclear migration to the female gametophyte center" EXACT [] synonym: "nuclear migration to the female gametophyte centre" EXACT [] synonym: "nuclear migration to the megagametophyte center" EXACT [] synonym: "nuclear migration to the megagametophyte centre" EXACT [] synonym: "nucleus migration to the female gametophyte center" EXACT [] synonym: "nucleus migration to the female gametophyte centre" EXACT [] is_a: GO:0009562 ! embryo sac nuclear migration [Term] id: GO:0023004 name: obsolete activation of dopamine receptor signaling pathway namespace: biological_process def: "OBSOLETE. Any process that initiates the dopamine receptor protein signaling pathway through stimulation of the dopamine receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "activation of dopamine receptor signaling pathway" EXACT [] synonym: "activation of dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "initiation of dopamine receptor signaling pathway" RELATED [] synonym: "stimulation of dopamine receptor signaling pathway" EXACT [] is_obsolete: true consider: GO:0060161 [Term] id: GO:0023005 name: obsolete signal initiation by neurotransmitter namespace: biological_process def: "OBSOLETE. The process in which a neurotransmitter signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by neurotransmitter" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0030594 [Term] id: GO:0023006 name: obsolete signal initiation by amino acid namespace: biological_process def: "OBSOLETE. The process in which an amino acid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by amino acid" EXACT [] is_obsolete: true consider: GO:0007215 consider: GO:0008066 consider: GO:0071230 [Term] id: GO:0023007 name: obsolete ligand binding to T cell receptor namespace: biological_process def: "OBSOLETE. Binding of a diffusible ligand to a T cell receptor as part of a signaling process." [GOC:jid, GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. synonym: "ligand binding to T cell receptor" EXACT [] is_obsolete: true consider: GO:0042101 consider: GO:0042608 consider: GO:0050852 [Term] id: GO:0023009 name: obsolete initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "initiation of T cell receptor signaling" EXACT [] synonym: "initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0038023 consider: GO:0042101 consider: GO:0048018 consider: GO:0050852 [Term] id: GO:0023010 name: obsolete regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "regulation of initiation of T cell receptor signaling" EXACT [] synonym: "regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050856 [Term] id: GO:0023011 name: obsolete positive regulation of initiation of T cell receptor signaling namespace: biological_process def: "OBSOLETE. Any process that activates, maintains or increases the frequency, rate or extent of the initiation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "positive regulation of initiation of T cell receptor signaling" EXACT [] synonym: "positive regulation of initiation of T cell receptor signalling" EXACT [GOC:mah] is_obsolete: true consider: GO:0050862 [Term] id: GO:0023012 name: obsolete initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor namespace: biological_process def: "OBSOLETE. The process in which binding of an MHC complex to T cell receptor causes activation of T cell receptor signaling." [GOC:mtg_signal] comment: This term was made obsolete because it is describing a binding molecular function. synonym: "initiation of T cell receptor signaling by binding of a MHC complex to T cell receptor" EXACT [] synonym: "initiation of T cell receptor signalling by binding of a MHC complex to T cell receptor" EXACT [GOC:mah] is_obsolete: true consider: GO:0042101 consider: GO:0050852 [Term] id: GO:0023014 name: signal transduction by protein phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups to a substrate transmits a signal to the phosphorylated substrate." [GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via phosphorylation event" RELATED [GOC:bf] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0007165 ! signal transduction [Term] id: GO:0023015 name: signal transduction by cis-phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in the same kinase molecule transmits a signal. For example, ligand-binding can induce autophosphorylation of the activated receptor, creating binding sites for intracellular signaling molecules." [GOC:bf, GOC:mtg_signal, GOC:signaling] synonym: "signal transduction via a cis-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via a cis-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via auto-phosphorylation" RELATED [] is_a: GO:0023014 ! signal transduction by protein phosphorylation [Term] id: GO:0023016 name: signal transduction by trans-phosphorylation namespace: biological_process def: "A process in which the transfer of one or more phosphate groups by a kinase to a residue in a different protein molecule transmits a signal." [GOC:bf, GOC:mtg_signal] synonym: "signal transduction via a trans-phosphorylation event" RELATED [GOC:bf] synonym: "signal transmission via a trans-phosphorylation event" RELATED [GOC:bf] is_a: GO:0023014 ! signal transduction by protein phosphorylation [Term] id: GO:0023017 name: obsolete signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via a diffusible molecule." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via diffusible molecule" EXACT [] synonym: "signaling via diffusible mediator" EXACT [] is_obsolete: true consider: GO:0007267 [Term] id: GO:0023018 name: obsolete T cell activation of signal transmission via diffusible molecule namespace: biological_process def: "OBSOLETE. The process in which signal transmission via a diffusible molecule is initiated by a T cell." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "T cell activation of signal transmission via diffusible molecule" EXACT [] is_obsolete: true [Term] id: GO:0023019 name: signal transduction involved in regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] synonym: "regulation of gene expression as a consequence of signal transmission" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0010468 ! regulation of gene expression [Term] id: GO:0023020 name: obsolete regulation of gene expression as a consequence of T cell signal transmission namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of gene expression as a consequence of a process in which a T cell signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "regulation of gene expression as a consequence of T cell signal transmission" EXACT [] is_obsolete: true consider: GO:0023019 [Term] id: GO:0023021 name: termination of signal transduction namespace: biological_process def: "The signaling process in which signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] comment: Note that this term encompasses both the control point when the instruction is given for the process to cease and the actual cessation of the process. A process can persist for some time after that signal that induced the process is withdrawn. is_a: GO:0009968 ! negative regulation of signal transduction [Term] id: GO:0023022 name: termination of T cell signal transduction namespace: biological_process def: "The signaling process in which T cell signal transduction is brought to an end rather than being reversibly modulated." [GOC:mtg_signal] is_a: GO:0023021 ! termination of signal transduction is_a: GO:0050860 ! negative regulation of T cell receptor signaling pathway relationship: part_of GO:0050852 ! T cell receptor signaling pathway [Term] id: GO:0023023 name: MHC protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0023024 name: MHC class I protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class I major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023025 name: MHC class Ib protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class Ib major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023026 name: MHC class II protein complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the class II major histocompatibility complex." [GOC:mtg_signal, GOC:vw] is_a: GO:0023023 ! MHC protein complex binding [Term] id: GO:0023027 name: MHC class I protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] is_a: GO:0042288 ! MHC class I protein binding relationship: part_of GO:0023024 ! MHC class I protein complex binding [Term] id: GO:0023028 name: MHC class I protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class I molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] is_a: GO:0042288 ! MHC class I protein binding [Term] id: GO:0023029 name: MHC class Ib protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules." [GOC:mtg_signal, GOC:vw] is_a: GO:0042287 ! MHC protein binding [Term] id: GO:0023030 name: MHC class Ib protein binding, via antigen binding groove namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the antigen binding groove." [GOC:mtg_signal, GOC:vw] is_a: GO:0023029 ! MHC class Ib protein binding relationship: part_of GO:0023025 ! MHC class Ib protein complex binding [Term] id: GO:0023031 name: MHC class Ib protein binding, via lateral surface namespace: molecular_function def: "Interacting selectively and non-covalently with major histocompatibility complex class Ib molecules via the lateral surface." [GOC:mtg_signal, GOC:vw] is_a: GO:0023029 ! MHC class Ib protein binding [Term] id: GO:0023035 name: CD40 signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of the cell surface receptor CD40 to one of its physiological ligands, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:mtg_signal, GOC:signaling, PMID:11348017] synonym: "CD40 signalling pathway" EXACT [GOC:mah] is_a: GO:0007166 ! cell surface receptor signaling pathway [Term] id: GO:0023036 name: obsolete initiation of signal transduction namespace: biological_process def: "OBSOLETE. The process in which a signal causes activation of a receptor, for example, via a conformation change." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. Note that this term was intended for the annotation of both ligands and receptors. synonym: "initiation of signal transduction" EXACT [] synonym: "signal reception" RELATED [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0048018 [Term] id: GO:0023037 name: obsolete signal initiation by light namespace: biological_process def: "OBSOLETE. The process in which a light signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by light" EXACT [] is_obsolete: true consider: GO:0009785 consider: GO:0009881 consider: GO:0010017 consider: GO:0010018 consider: GO:0010161 [Term] id: GO:0023038 name: obsolete signal initiation by diffusible mediator namespace: biological_process def: "OBSOLETE. The process in which a diffusible signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by diffusible mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038001 consider: GO:0038023 consider: GO:0048018 [Term] id: GO:0023039 name: obsolete signal initiation by physical damage namespace: biological_process def: "OBSOLETE. The process in which a physical damage signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by physical damage" EXACT [] is_obsolete: true consider: GO:0033554 consider: GO:0038023 [Term] id: GO:0023040 name: obsolete signaling via ionic flux namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via ionic flux." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via ionic flux" EXACT [] synonym: "signalling via ionic flux" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023041 name: neuronal signal transduction namespace: biological_process def: "The process in which an activated neuronal cell receptor conveys information down a signaling pathway, resulting in a change in the function or state of a cell. This process may be intracellular or intercellular." [GOC:mtg_signal] is_a: GO:0007165 ! signal transduction [Term] id: GO:0023042 name: obsolete signaling via protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a protein/peptide mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via protein/peptide mediator" EXACT [] synonym: "signalling via protein/peptide mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023043 name: obsolete signaling via lipid mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a lipid mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via lipid mediator" EXACT [] synonym: "signalling via lipid mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0014065 consider: GO:0023052 [Term] id: GO:0023044 name: obsolete signaling via chemical mediator namespace: biological_process def: "OBSOLETE. The process in which information is sent from one location to another, within a living organism or between living organisms, via a chemical mediator." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signaling via chemical mediator" EXACT [] synonym: "signalling via chemical mediator" EXACT [GOC:mah] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023045 name: signal transduction by conformational transition namespace: biological_process def: "A process where induction of a conformational change in a molecule transmits a signal to that molecule." [GOC:bf, GOC:mtg_signal] synonym: "signal transduction via conformational transition" RELATED [GOC:bf] synonym: "signal transmission via conformational transition" RELATED [GOC:bf] is_a: GO:0007165 ! signal transduction [Term] id: GO:0023047 name: obsolete signal initiation by chemical mediator namespace: biological_process def: "OBSOLETE. The process in which a chemical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by chemical mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0070887 [Term] id: GO:0023048 name: obsolete signal initiation by lipid mediator namespace: biological_process def: "OBSOLETE. The process in which a lipid signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by lipid mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0045125 [Term] id: GO:0023049 name: obsolete signal initiation by protein/peptide mediator namespace: biological_process def: "OBSOLETE. The process in which a protein/peptide signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by protein/peptide mediator" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0048018 [Term] id: GO:0023050 name: obsolete consequence of signal transmission namespace: biological_process def: "OBSOLETE. The steps whereby the downstream processes started by a signal are brought to a conclusion. Examples include destruction of cAMP by PDE, or endocytosis resulting from receptor phosphorylation. The termination process ends when the receptor has returned to its inactive state." [GOC:mtg_signal] comment: This term was made obsolete because the term is no longer needed. synonym: "consequence of signal transmission" EXACT [] synonym: "signal termination" EXACT [] is_obsolete: true [Term] id: GO:0023051 name: regulation of signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "regulation of signaling process" RELATED [GOC:bf] synonym: "regulation of signalling process" RELATED [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0023052 ! signaling [Term] id: GO:0023052 name: signaling namespace: biological_process alt_id: GO:0023046 alt_id: GO:0044700 def: "The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered." [GOC:mtg_signal, GOC:mtg_signaling_feb11, GOC:signaling] comment: Note that a signal is any variable property or parameter that serves to convey information, and may be a physical entity such as a gene product or small molecule, a photon, or a change in state such as movement or voltage change. subset: goslim_agr subset: goslim_flybase_ribbon subset: goslim_mouse subset: goslim_pombe subset: goslim_yeast synonym: "biological signaling" EXACT [] synonym: "signaling process" EXACT [] synonym: "signalling" EXACT [] synonym: "signalling process" RELATED [GOC:mah] synonym: "single organism signaling" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0023053 name: obsolete signal initiation by mechanical effect namespace: biological_process def: "OBSOLETE. The process in which a mechanical signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by mechanical effect" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 consider: GO:0071260 [Term] id: GO:0023054 name: obsolete signal initiation by stretch effect namespace: biological_process def: "OBSOLETE. The process in which a stretch signal causes activation of a receptor." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by stretch effect" EXACT [] is_obsolete: true consider: GO:0007165 consider: GO:0038023 [Term] id: GO:0023055 name: obsolete signal initiation by peptide hormone namespace: biological_process def: "OBSOLETE. The process in which a signal is initiated by a peptide hormone." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal initiation by peptide hormone" EXACT [] is_obsolete: true consider: GO:0004879 consider: GO:0005179 consider: GO:0009755 [Term] id: GO:0023056 name: positive regulation of signaling namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "positive regulation of signaling process" RELATED [GOC:bf] synonym: "positive regulation of signalling process" EXACT [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0023052 ! signaling [Term] id: GO:0023057 name: negative regulation of signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a signaling process." [GOC:mtg_signal] synonym: "negative regulation of signaling process" RELATED [GOC:bf] synonym: "negative regulation of signalling process" RELATED [GOC:mah] is_a: GO:0023051 ! regulation of signaling is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0023052 ! signaling [Term] id: GO:0023058 name: adaptation of signaling pathway namespace: biological_process def: "The regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009966 ! regulation of signal transduction [Term] id: GO:0023059 name: positive adaptation of signaling pathway namespace: biological_process def: "The positive regulation of a signal transduction pathway in response to a stimulus upon prolonged exposure to that stimulus." [GOC:mtg_signal] synonym: "positive adaptation of signalling pathway" EXACT [GOC:mah] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0023060 name: obsolete signal transmission namespace: biological_process def: "OBSOLETE. The process in which a signal is released and/or conveyed from one location to another." [GOC:mtg_signal] comment: This term was made obsolete because it was an unnecessary grouping term. synonym: "signal transmission" EXACT [] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023061 name: signal release namespace: biological_process def: "The process in which a signal is secreted or discharged into the extracellular medium from a cellular source." [GOC:mtg_signal] synonym: "signal secretion" EXACT [GOC:bf] is_a: GO:0032940 ! secretion by cell relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0023062 name: obsolete signal transmission via transcytosis namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via transcytosis. Transcytosis is the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side." [GOC:mtg_signal, ISBN:0716731363] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via transcytosis" EXACT [] is_obsolete: true consider: GO:0023052 consider: GO:0045056 [Term] id: GO:0023065 name: obsolete signal transmission via blood namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via blood." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via blood" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023066 name: obsolete signal transmission via vascular system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the vascular system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via vascular system" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023067 name: obsolete signal transmission via lymphatic system namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the lymphatic system." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via lymphatic system" EXACT [] is_obsolete: true consider: GO:0023052 [Term] id: GO:0023068 name: obsolete signal transmission via phloem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the phloem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via phloem" EXACT [] is_obsolete: true consider: GO:0010233 consider: GO:0023052 [Term] id: GO:0023069 name: obsolete signal transmission via xylem namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the xylem." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via xylem" EXACT [] is_obsolete: true consider: GO:0010232 consider: GO:0023052 [Term] id: GO:0023070 name: obsolete signal transmission via air namespace: biological_process def: "OBSOLETE. The process in which a signal is conveyed via the air." [GOC:mtg_signal] comment: This term was made obsolete because the meaning of the term is ambiguous. synonym: "signal transmission via air" EXACT [] is_obsolete: true [Term] id: GO:0030001 name: metal ion transport namespace: biological_process def: "The directed movement of metal ions, any metal ion with an electric charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ai] synonym: "heavy metal ion transport" NARROW [] is_a: GO:0006812 ! cation transport [Term] id: GO:0030002 name: cellular anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of anions at the level of a cell." [GOC:ceb, GOC:mah] is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055081 ! anion homeostasis [Term] id: GO:0030003 name: cellular cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of cations at the level of a cell." [GOC:ceb, GOC:mah] is_a: GO:0006873 ! cellular ion homeostasis is_a: GO:0055080 ! cation homeostasis [Term] id: GO:0030004 name: cellular monovalent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic cations at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0030005 name: obsolete cellular di-, tri-valent inorganic cation homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of divalent or trivalent cations at the level of a cell." [GOC:ceb, GOC:mah] synonym: "cellular di-, tri-valent inorganic cation homeostasis" EXACT [] is_obsolete: true consider: GO:0072503 consider: GO:0072504 [Term] id: GO:0030006 name: obsolete heavy cellular metal ion homeostasis namespace: biological_process def: "OBSOLETE. Regulation of the levels, transport, and metabolism of ions of a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). synonym: "heavy cellular metal ion homeostasis" EXACT [] is_obsolete: true consider: GO:0006875 [Term] id: GO:0030007 name: cellular potassium ion homeostasis namespace: biological_process alt_id: GO:0017079 def: "Any process involved in the maintenance of an internal steady state of potassium ions at the level of a cell." [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055075 ! potassium ion homeostasis [Term] id: GO:0030008 name: TRAPP complex namespace: cellular_component def: "A large complex that acts as a tethering factor involved in transporting vesicles from the ER through the Golgi to the plasma membrane. A TRAPP (transport protein particle) complex has a core set of proteins which are joined by specific subunits depending on the cellular component where a given TRAPP complex is active." [GOC:bhm, GOC:vw, PMID:22669257] synonym: "transport protein particle" EXACT [] synonym: "transport protein particle complex" EXACT [GOC:bhm] synonym: "TRAPP1" NARROW [GOC:vw] synonym: "TRAPP2" NARROW [GOC:vw] xref: Wikipedia:TRAPP_complex is_a: GO:0044424 ! intracellular part is_a: GO:0099023 ! tethering complex [Term] id: GO:0030009 name: obsolete complement factor H activity namespace: molecular_function def: "OBSOLETE. A cofactor for the serine protease complement factor I." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. synonym: "complement factor H activity" EXACT [] is_obsolete: true consider: GO:0006956 [Term] id: GO:0030010 name: establishment of cell polarity namespace: biological_process alt_id: GO:0000283 alt_id: GO:0030468 def: "The specification and formation of anisotropic intracellular organization or cell growth patterns." [GOC:mah] synonym: "bud site selection/establishment of cell polarity" NARROW [] synonym: "cell polarization" EXACT [] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030011 name: maintenance of cell polarity namespace: biological_process alt_id: GO:0030013 alt_id: GO:0030469 def: "The maintenance of established anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030014 name: CCR4-NOT complex namespace: cellular_component def: "The evolutionarily conserved CCR4-NOT complex is involved in several aspects of mRNA metabolism, including repression and activation of mRNA initiation, control of mRNA elongation, and the deadenylation and subsequent degradation of mRNA. In Saccharomyces the CCR4-NOT complex comprises a core complex of 9 proteins (Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p), Caf4p, Caf16p, and several less well characterized proteins." [GOC:sart, PMID:11113136] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030015 name: CCR4-NOT core complex namespace: cellular_component def: "The core of the CCR4-NOT complex. In Saccharomyces the CCR4-NOT core complex comprises Ccr4p, Caf1p, Caf40p, Caf130p, Not1p, Not2p, Not3p, Not4p, and Not5p." [GOC:sart, PMID:11113136] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0030014 ! CCR4-NOT complex [Term] id: GO:0030016 name: myofibril namespace: cellular_component def: "The contractile element of skeletal and cardiac muscle; a long, highly organized bundle of actin, myosin, and other proteins that contracts by a sliding filament mechanism." [ISBN:0815316194] synonym: "striated muscle fiber" RELATED [] synonym: "striated muscle fibre" RELATED [] xref: Wikipedia:Myofibril is_a: GO:0043292 ! contractile fiber [Term] id: GO:0030017 name: sarcomere namespace: cellular_component def: "The repeating unit of a myofibril in a muscle cell, composed of an array of overlapping thick and thin filaments between two adjacent Z discs." [ISBN:0815316194] xref: Wikipedia:Sarcomere is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030016 ! myofibril [Term] id: GO:0030018 name: Z disc namespace: cellular_component def: "Platelike region of a muscle sarcomere to which the plus ends of actin filaments are attached." [GOC:mtg_muscle, ISBN:0815316194] synonym: "Z band" EXACT [] synonym: "Z disk" EXACT [] synonym: "Z line" EXACT [] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031674 ! I band [Term] id: GO:0030019 name: obsolete tryptase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa, but with more restricted specificity than trypsin." [EC:3.4.21.59] comment: This term was made obsolete because it represents a gene product. synonym: "lung tryptase activity" NARROW [EC:3.4.21.59] synonym: "mast cell neutral proteinase activity" EXACT [EC:3.4.21.59] synonym: "mast cell protease II activity" NARROW [EC:3.4.21.59] synonym: "mast cell proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase II" RELATED [EC:3.4.21.59] synonym: "mast cell serine proteinase tryptase activity" EXACT [EC:3.4.21.59] synonym: "mast cell tryptase activity" NARROW [EC:3.4.21.59] synonym: "pituitary tryptase activity" NARROW [EC:3.4.21.59] synonym: "rat mast cell protease II" RELATED [EC:3.4.21.59] synonym: "skin tryptase activity" NARROW [EC:3.4.21.59] synonym: "tryptase activity" EXACT [] synonym: "tryptase M" RELATED [EC:3.4.21.59] xref: EC:3.4.21.59 xref: MetaCyc:3.4.21.59-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030020 name: extracellular matrix structural constituent conferring tensile strength namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist longitudinal stress." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix collagen proteins may be annotated to this term. PMID:29632050, PMID:24443019 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030021 name: extracellular matrix structural constituent conferring compression resistance namespace: molecular_function def: "A constituent of the extracellular matrix that enables the matrix to resist compressive forces; often a proteoglycan." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix proteoglycans may be annotated to this term. PMID:8346704 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030022 name: obsolete adhesive extracellular matrix constituent namespace: molecular_function def: "OBSOLETE. A constituent of the extracellular matrix that facilitates attachment of cells to the matrix." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because it does not represent a molecular function. synonym: "adhesive extracellular matrix constituent" EXACT [] is_obsolete: true consider: GO:0005578 consider: GO:0030674 consider: GO:0050839 consider: GO:0050840 [Term] id: GO:0030023 name: extracellular matrix constituent conferring elasticity namespace: molecular_function def: "A component of the extracellular matrix that enables the matrix to recoil after transient stretching." [GOC:mah, ISBN:0815316194] comment: Extracellular matrix elastin proteins may be annotated to this term. PMID:27009176, PMID:24443019 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] synonym: "elastin" RELATED [] is_a: GO:0005201 ! extracellular matrix structural constituent is_a: GO:0097493 ! structural molecule activity conferring elasticity [Term] id: GO:0030026 name: cellular manganese ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of manganese ions at the level of a cell." [GOC:mah] synonym: "manganese homeostasis" BROAD [] is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055071 ! manganese ion homeostasis [Term] id: GO:0030027 name: lamellipodium namespace: cellular_component def: "A thin sheetlike process extended by the leading edge of a migrating cell or extending cell process; contains a dense meshwork of actin filaments." [ISBN:0815316194] xref: Wikipedia:Lamellipodia is_a: GO:0120025 ! plasma membrane bounded cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0030029 name: actin filament-based process namespace: biological_process def: "Any cellular process that depends upon or alters the actin cytoskeleton, that part of the cytoskeleton comprising actin filaments and their associated proteins." [GOC:mah] synonym: "microfilament-based process" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0030030 name: cell projection organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection organisation" EXACT [GOC:curators] synonym: "cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "cell surface structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0030031 name: cell projection assembly namespace: biological_process def: "Formation of a prolongation or process extending from a cell, e.g. a flagellum or axon." [GOC:jl, GOC:mah, http://www.cogsci.princeton.edu/~wn/] synonym: "cell projection biogenesis" RELATED [GOC:mah] synonym: "formation of a cell surface projection" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030030 ! cell projection organization [Term] id: GO:0030032 name: lamellipodium assembly namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell." [GOC:mah, ISBN:0815316194] synonym: "lamellipodium biogenesis" RELATED [GOC:mah] synonym: "lamellipodium biosynthesis" EXACT [] synonym: "lamellipodium formation" EXACT [] is_a: GO:0097581 ! lamellipodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030033 name: microvillus assembly namespace: biological_process def: "Formation of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah, ISBN:0815316194] synonym: "microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030034 name: microvillar actin bundle assembly namespace: biological_process def: "Assembly of the parallel bundle of actin filaments at the core of a microvillus." [GOC:mah] is_a: GO:0030046 ! parallel actin filament bundle assembly relationship: part_of GO:0030033 ! microvillus assembly [Term] id: GO:0030035 name: microspike assembly namespace: biological_process def: "Formation of a microspike, a dynamic, actin-rich projection extending from the surface of a migrating animal cell." [ISBN:0815316194, PMID:11429692, PMID:12153987, PMID:19095735] comment: Although in some literature 'microspike' and 'filopodium' are used synonymously, in GO microspike refers to a cell projection that is distinct from a filopodium. For the assembly of filopodia, use 'filopodium assembly ; GO:0046847'. synonym: "microspike biogenesis" RELATED [GOC:mah] synonym: "microspike biosynthesis" EXACT [] synonym: "microspike formation" EXACT [] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0030036 name: actin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe synonym: "actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "actin modulating activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030037 name: actin filament reorganization involved in cell cycle namespace: biological_process def: "The cell cycle process in which rearrangement of the spatial distribution of actin filaments and associated proteins occurs." [GOC:mah] synonym: "actin filament reorganisation involved in cell cycle" EXACT [GOC:mah] synonym: "actin filament reorganization during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0090527 ! actin filament reorganization [Term] id: GO:0030038 name: contractile actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030039 name: obsolete DNA unwinding factor namespace: molecular_function alt_id: GO:0017152 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. synonym: "DNA unwinding factor" EXACT [] is_obsolete: true replaced_by: GO:0006268 [Term] id: GO:0030041 name: actin filament polymerization namespace: biological_process def: "Assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "actin polymerization" EXACT [] synonym: "actin polymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051258 ! protein polymerization [Term] id: GO:0030042 name: actin filament depolymerization namespace: biological_process def: "Disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "actin depolymerization" EXACT [] synonym: "actin depolymerizing activity" RELATED [] is_a: GO:0008154 ! actin polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0030043 name: actin filament fragmentation namespace: biological_process def: "The severing of actin filaments into numerous short fragments, usually mediated by actin severing proteins." [GOC:mah, ISBN:0815316194] is_a: GO:0030042 ! actin filament depolymerization [Term] id: GO:0030046 name: parallel actin filament bundle assembly namespace: biological_process def: "Assembly of actin filament bundles in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity." [GOC:mah, ISBN:0815316194] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0030047 name: actin modification namespace: biological_process alt_id: GO:0007013 def: "Covalent modification of an actin molecule." [GOC:mah] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0030048 name: actin filament-based movement namespace: biological_process def: "Movement of organelles or other particles along actin filaments, or sliding of actin filaments past each other, mediated by motor proteins." [GOC:BHF, GOC:mah] is_a: GO:0006928 ! movement of cell or subcellular component is_a: GO:0030029 ! actin filament-based process [Term] id: GO:0030049 name: muscle filament sliding namespace: biological_process def: "The sliding of actin thin filaments and myosin thick filaments past each other in muscle contraction. This involves a process of interaction of myosin located on a thick filament with actin located on a thin filament. During this process ATP is split and forces are generated." [GOC:mah, GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0033275 ! actin-myosin filament sliding relationship: part_of GO:0006936 ! muscle contraction [Term] id: GO:0030050 name: vesicle transport along actin filament namespace: biological_process def: "Movement of a vesicle along an actin filament, mediated by motor proteins." [GOC:mah] is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport is_a: GO:0099518 ! vesicle cytoskeletal trafficking [Term] id: GO:0030051 name: obsolete FK506-sensitive peptidyl-prolyl cis-trans isomerase namespace: molecular_function def: "OBSOLETE. Interacts selectively with the immunosuppressant FK506, and possesses peptidyl-prolyl isomerase activity (catalysis of the reaction: peptidoproline (omega=180) = peptidylproline (omega=0))." [EC:5.2.1.8, ISBN:0198596732] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "FK506 binding protein" RELATED [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" EXACT [] synonym: "FKBP" RELATED [] is_obsolete: true consider: GO:0003755 consider: GO:0005528 [Term] id: GO:0030052 name: obsolete parvulin namespace: molecular_function def: "OBSOLETE. A peptidyl-prolyl isomerase isolated from Escherichia coli. It does not have any function as an immunophilin." [ISBN:0198506732] comment: This term was made obsolete because it describes a gene product. synonym: "parvulin" EXACT [] is_obsolete: true replaced_by: GO:0003755 [Term] id: GO:0030053 name: obsolete immunophilin namespace: molecular_function def: "OBSOLETE. Any member of a family of receptors that includes the major FK506 binding protein FKBP and cyclophilin. These two proteins are unrelated in amino-acid sequence, but both possess peptidyl-prolyl isomerase activity which is blocked by immunosuppressants that block signal-transduction pathways leading to T cell activation such as FK506 and rapamycin, which block FKBP, or cyclosporin A, which blocks cyclophilin." [ISBN:0198506732] comment: This term was made obsolete because it does not represent a molecular function. synonym: "immunophilin" EXACT [] is_obsolete: true consider: GO:0003755 [Term] id: GO:0030054 name: cell junction namespace: cellular_component def: "A cellular component that forms a specialized region of connection between two or more cells or between a cell and the extracellular matrix. At a cell junction, anchoring proteins extend through the plasma membrane to link cytoskeletal proteins in one cell to cytoskeletal proteins in neighboring cells or to proteins in the extracellular matrix." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732] subset: goslim_agr subset: goslim_flybase_ribbon xref: Wikipedia:Cell_junction is_a: GO:0005575 ! cellular_component [Term] id: GO:0030055 name: cell-substrate junction namespace: cellular_component def: "A cell junction that forms a connection between a cell and the extracellular matrix." [GOC:hb, GOC:mah] synonym: "cell-matrix junction" EXACT [] is_a: GO:0030054 ! cell junction [Term] id: GO:0030056 name: hemidesmosome namespace: cellular_component def: "A cell-substrate junction (attachment structure) found in epithelial cells that links intermediate filaments to extracellular matrices via transmembrane complexes. In vertebrates, hemidesmosomes mediate contact between the basal side of epithelial cells and the basal lamina. In C. elegans, hemidesmosomes connect epithelial cells to distinct extracellular matrices on both the apical and basal cell surfaces." [GOC:kmv, ISBN:0815316208, PMID:20205195] synonym: "epidermal attachment structure" NARROW [GOC:kmv] synonym: "fibrous organelle" NARROW [GOC:kmv, PMID:20205195] synonym: "hemi-adherens junction" RELATED [http://www.wormatlas.org/glossaries/hglossary.htm#hemiadherensjunction] synonym: "trans-epithelial attachment" NARROW [GOC:kmv, PMID:20205195] xref: Wikipedia:Hemidesmosome is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0030057 name: desmosome namespace: cellular_component def: "A cell-cell junction in which: on the cytoplasmic surface of each interacting plasma membrane is a dense plaque composed of a mixture of intracellular anchor proteins; a bundle of keratin intermediate filaments is attached to the surface of each plaque; transmembrane adhesion proteins of the cadherin family bind to the plaques and interact through their extracellular domains to hold the adjacent membranes together by a Ca2+-dependent mechanism." [GOC:mah, GOC:mtg_muscle, ISBN:0815332181] synonym: "macula adherens" EXACT [] synonym: "spot desmosome" EXACT [] xref: Wikipedia:Desmosome is_a: GO:0005911 ! cell-cell junction is_a: GO:0070161 ! anchoring junction [Term] id: GO:0030058 name: amine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: R-CH2-NH2 + H2O + acceptor = R-CHO + NH3 + reduced acceptor." [EC:1.4.99.3] comment: This term represents a transferred EC activity and is scheduled for obsoletion. synonym: "amine: (acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "MADH activity" EXACT [EC:1.4.99.3] synonym: "methylamine dehydrogenase activity" RELATED [EC:1.4.99.3] synonym: "primary-amine dehydrogenase activity" BROAD [EC:1.4.99.3] synonym: "primary-amine:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] synonym: "primary-amine:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.3] xref: EC:1.4.99.3 xref: MetaCyc:AMINE-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0058 is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0030059 name: aralkylamine dehydrogenase (azurin) activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + arCH(2)NH(2) + 2 azurin = 2 reduced azurin + ArCHO + NH(3). The symbol arCH(2)NH(2) represents an aralkylamine and ArCHO is an aryl aldehyde." [EC:1.4.9.2] synonym: "aralkylamine:(azurin) oxidoreductase (deaminating) activity" EXACT [EC:1.4.9.2] synonym: "aromatic amine dehydrogenase (azurin) activity" EXACT [EC:1.4.9.2] synonym: "arylamine dehydrogenase activity" BROAD [EC:1.4.9.2] synonym: "dehydrogenase, arylamine (azurin) activity" EXACT [EC:1.4.9.2] synonym: "tyramine dehydrogenase (azurin) activity" NARROW [EC:1.4.9.2] xref: EC:1.4.9.2 xref: MetaCyc:ARALKYLAMINE-DEHYDROGENASE-RXN is_a: GO:0052877 ! oxidoreductase activity, acting on the CH-NH2 group of donors, with a copper protein as acceptor [Term] id: GO:0030060 name: L-malate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = oxaloacetate + NADH + H+." [EC:1.1.1.37] synonym: "(S)-malate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "L-malate-NAD+ oxidoreductase activity" EXACT [EC:1.1.1.37] synonym: "malate (NAD) dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic acid dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "MDH" RELATED [EC:1.1.1.37] synonym: "NAD-dependent malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-dependent malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-L-malate dehydrogenase activity" EXACT [] synonym: "NAD-linked malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malate dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-malic dehydrogenase activity" EXACT [EC:1.1.1.37] synonym: "NAD-specific malate dehydrogenase activity" EXACT [EC:1.1.1.37] xref: EC:1.1.1.37 xref: MetaCyc:MALATE-DEH-RXN xref: reactome:R-HSA-198508 "malate + NAD+ <=> oxaloacetate + NADH + H+" xref: reactome:R-HSA-70979 "(S)-Malate + NAD+ <=> Oxaloacetate + NADH + H+" xref: reactome:R-HSA-71783 "Oxaloacetate + NADH + H+ <=> (S)-Malate + NAD+" xref: RHEA:21432 is_a: GO:0016615 ! malate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030061 name: mitochondrial crista namespace: cellular_component def: "Any of the inward folds of the mitochondrial inner membrane. Their number, extent, and shape differ in mitochondria from different tissues and organisms. They appear to be devices for increasing the surface area of the mitochondrial inner membrane, where the enzymes of electron transport and oxidative phosphorylation are found. Their shape can vary with the respiratory state of the mitochondria." [ISBN:0198506732] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "cristae" BROAD [NIF_Subcellular:sao333328131] synonym: "mitochondrial cristae" EXACT [] xref: NIF_Subcellular:sao333328131 is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0030062 name: mitochondrial tricarboxylic acid cycle enzyme complex namespace: cellular_component def: "Any of the heteromeric enzymes, located in the mitochondrion, that act in the tricarboxylic acid (TCA) cycle." [GOC:mah, GOC:mtg_sensu] synonym: "TCA cycle enzyme complex" BROAD [] is_a: GO:0045239 ! tricarboxylic acid cycle enzyme complex is_a: GO:0098798 ! mitochondrial protein complex relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0030063 name: obsolete murein sacculus namespace: cellular_component def: "OBSOLETE. A structure formed of the cross-linked polymer peptidoglycan (also called murein) that forms a covalently closed net around a bacterial cell, and imparts structural stability to the bacterial cell wall." [GOC:mah, PMID:9529891] comment: This term was made obsolete because it was defined inaccurately. synonym: "murein sacculus" EXACT [] synonym: "peptidoglycan layer" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0030064 name: obsolete cell wall inner membrane namespace: cellular_component def: "OBSOLETE. The peptidoglycan layer of the cell wall of Gram-negative bacteria." [ISBN:0135712254] comment: This term was made obsolete because it was defined inaccurately. synonym: "cell wall inner membrane" EXACT [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0030066 name: obsolete cytochrome b6 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "cytochrome b-563" RELATED [] synonym: "cytochrome b6" EXACT [] is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0030067 name: obsolete respiratory chain cytochrome b6 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "respiratory chain cytochrome b6" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0030068 name: obsolete lytic viral life cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "lytic viral life cycle" EXACT [] is_obsolete: true consider: GO:0019058 consider: GO:0044659 [Term] id: GO:0030070 name: insulin processing namespace: biological_process def: "The formation of mature insulin by proteolysis of the precursor preproinsulin. The signal sequence is first cleaved from preproinsulin to form proinsulin; proinsulin is then cleaved to release the C peptide, leaving the A and B chains of mature insulin linked by disulfide bridges." [ISBN:0198506732] is_a: GO:0016486 ! peptide hormone processing is_a: GO:1901142 ! insulin metabolic process [Term] id: GO:0030071 name: regulation of mitotic metaphase/anaphase transition namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which a cell progresses from metaphase to anaphase during mitosis, triggered by the activation of the anaphase promoting complex by Cdc20/Sleepy homolog which results in the degradation of Securin." [GOC:mah] is_a: GO:0010965 ! regulation of mitotic sister chromatid separation is_a: GO:1901990 ! regulation of mitotic cell cycle phase transition is_a: GO:1902099 ! regulation of metaphase/anaphase transition of cell cycle relationship: regulates GO:0007091 ! metaphase/anaphase transition of mitotic cell cycle [Term] id: GO:0030072 name: peptide hormone secretion namespace: biological_process def: "The regulated release of a peptide hormone from a cell." [GOC:mah] is_a: GO:0002790 ! peptide secretion is_a: GO:0046879 ! hormone secretion [Term] id: GO:0030073 name: insulin secretion namespace: biological_process def: "The regulated release of proinsulin from secretory granules accompanied by cleavage of proinsulin to form mature insulin. In vertebrates, insulin is secreted from B granules in the B cells of the vertebrate pancreas and from insulin-producing cells in insects." [GOC:mah, ISBN:0198506732] comment: Updated definition, added taxon constraint https://github.com/geneontology/go-ontology/issues/11255#issuecomment-426191045 is_a: GO:0009306 ! protein secretion is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030074 name: obsolete thylakoid (sensu Proteobacteria) namespace: cellular_component def: "OBSOLETE. A thylakoid; as in, but not restricted to, the purple bacteria and relatives (Proteobacteria, ncbi_taxonomy_id:1224)." [GOC:mah] comment: This term was made obsolete because thylakoids are not found in organisms of the Phylum Proteobacteria. synonym: "thylakoid (sensu Proteobacteria)" EXACT [] is_obsolete: true consider: GO:0042716 [Term] id: GO:0030075 name: bacterial thylakoid namespace: cellular_component def: "A thylakoid that is derived from and attached to, but not necessarily continuous with, the plasma membrane, and is not enclosed in a plastid. It bears the photosynthetic pigments in photosynthetic cyanobacteria." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane-derived thylakoid" EXACT [] is_a: GO:0009579 ! thylakoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0030076 name: light-harvesting complex namespace: cellular_component def: "A protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center." [GOC:lr] subset: goslim_pir synonym: "antenna complex" RELATED [] xref: Wikipedia:Light-harvesting_complex is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030077 name: plasma membrane light-harvesting complex namespace: cellular_component def: "A plasma membrane protein-pigment complex that may be closely or peripherally associated to photosynthetic reaction centers that participate in harvesting and transferring radiant energy to the reaction center. Examples of this complex are found in bacterial species." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0030078 name: light-harvesting complex, core complex namespace: cellular_component def: "Light harvesting complex associated with the reaction complex of photosynthetic purple bacteria." [GOC:lr] is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030079 name: light-harvesting complex, peripheral complex namespace: cellular_component def: "Bacteriochlorophyll a binding complex that is peripherally associated to the bacterial reaction center." [GOC:lr] is_a: GO:0030077 ! plasma membrane light-harvesting complex [Term] id: GO:0030080 name: B875 antenna complex namespace: cellular_component def: "Protein complex that surrounds and transfers excitation energy directly to the bacterial reaction center; binds bacteriochlorophyll a and has a single absorption band between 870 and 890 nm." [GOC:kd] synonym: "LH1 complex" EXACT [] synonym: "light harvesting complex I" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030078 ! light-harvesting complex, core complex [Term] id: GO:0030081 name: B800-820 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 820 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] synonym: "LH3 complex" EXACT [] synonym: "light harvesting complex III" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030082 name: B800-850 antenna complex namespace: cellular_component def: "Protein-pigment complex that absorbs light at 800 and 850 nm; is peripherally associated to the bacterial reaction center; transfers excitation energy to the B875 antenna complex." [GOC:kd, GOC:lr] synonym: "LH2 complex" EXACT [] synonym: "light harvesting complex II" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030079 ! light-harvesting complex, peripheral complex [Term] id: GO:0030083 name: PSI associated light-harvesting complex I, LHCIa subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 24 and 21.5 kDa); has a fluorescence maximum between 680 and 690 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030084 name: PSI associated light-harvesting complex I, LHCIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem I associated light-harvesting complex I; contains two proteins (usually about 20 kDa); has a fluorescence maximum of 730 nm." [PMID:8825475] is_a: GO:0009518 ! PSI associated light-harvesting complex I [Term] id: GO:0030085 name: PSII associated light-harvesting complex II, peripheral complex, LHCIIb subcomplex namespace: cellular_component def: "A pigment protein complex that forms part of the photosystem II associated light-harvesting complex II; contains two proteins (usually about 28 and 27 kDa), and may contain a third; peripherally located relative to other LHC polypeptides." [PMID:8825475] is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex relationship: part_of GO:0009656 ! PSII associated light-harvesting complex II, peripheral complex [Term] id: GO:0030086 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030087 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030088 name: obsolete PSII associated light-harvesting complex II, core complex, LHCIId subcomplex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the 'complex' it refers to contains only one gene product. synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" EXACT [] is_obsolete: true replaced_by: GO:0009655 [Term] id: GO:0030089 name: phycobilisome namespace: cellular_component def: "Any of the granules, approximately 32 nm x 48 nm and consisting of highly aggregated phycobiliproteins, that are attached in arrays to the external face of a thylakoid membrane in algae of the phyla Cyanophyta and Rhodophyta, where they function as light-harvesting devices in photosynthesis. Excitation energy in the phycobilisome flows in the sequence: phycoerythrin, phycocyanin, allophycocyanin before passing to the antenna chlorophyll of photosystem II." [GOC:jl, PMID:11734882, Wikipedia:Phycobilisome] xref: Wikipedia:Phycobilisome is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044436 ! thylakoid part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0030091 name: protein repair namespace: biological_process def: "The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues." [GOC:mlg] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0030092 name: obsolete regulation of flagellum assembly namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the formation of a flagellum." [GOC:go_curators] comment: This term was made obsolete because microtubule-based flagellum (GO:0009434) and motile cilium (GO:0031514), as referenced by this term, were determined to be equivalent and merged. When a merge for this term was considered, it was noticed that both eukaryotic and prokaryotic proteins are annotated to it because its meaning had been ambiguous so obsoletion was considered safest. synonym: "regulation of flagella assembly" RELATED [GOC:mah] synonym: "regulation of flagella biogenesis" RELATED [] synonym: "regulation of flagellum assembly" EXACT [] synonym: "regulation of flagellum biogenesis" RELATED [GOC:mah] is_obsolete: true consider: GO:1902017 consider: GO:1902208 [Term] id: GO:0030093 name: chloroplast photosystem I namespace: cellular_component def: "Photosystem located in the chloroplast that functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. An example of this is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009522 ! photosystem I is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex [Term] id: GO:0030094 name: plasma membrane-derived photosystem I namespace: cellular_component def: "A protein complex located in the plasma membrane-derived thylakoid. The photosystem functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin. Examples of this complex are found in bacterial species." [GOC:jid, GOC:mtg_sensu] synonym: "plasma membrane photosystem I" EXACT [] is_a: GO:0009522 ! photosystem I is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0030095 name: chloroplast photosystem II namespace: cellular_component def: "An integral chloroplast membrane complex containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009523 ! photosystem II is_a: GO:0098807 ! chloroplast thylakoid membrane protein complex [Term] id: GO:0030096 name: plasma membrane-derived thylakoid photosystem II namespace: cellular_component def: "A protein complex, located in the membrane-derived thylakoid, containing the P680 reaction center. In the light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone." [GOC:jid, GOC:mtg_sensu] synonym: "plasma membrane photosystem II" EXACT [] is_a: GO:0009523 ! photosystem II is_a: GO:0044422 ! organelle part is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0030097 name: hemopoiesis namespace: biological_process def: "The process whose specific outcome is the progression of the myeloid and lymphoid derived organ/tissue systems of the blood and other parts of the body over time, from formation to the mature structure. The site of hemopoiesis is variable during development, but occurs primarily in bone marrow or kidney in many adult vertebrates." [GOC:dgh, ISBN:0198506732] synonym: "blood cell biosynthesis" EXACT [] synonym: "blood cell formation" EXACT [] synonym: "haemopoiesis" EXACT [] synonym: "hematopoiesis" EXACT [] xref: Wikipedia:Haematopoiesis is_a: GO:0048534 ! hematopoietic or lymphoid organ development [Term] id: GO:0030098 name: lymphocyte differentiation namespace: biological_process alt_id: GO:0046650 def: "The process in which a relatively unspecialized precursor cell acquires specialized features of a lymphocyte. A lymphocyte is a leukocyte commonly found in the blood and lymph that has the characteristics of a large nucleus, a neutral staining cytoplasm, and prominent heterochromatin." [CL:0000542, GOC:go_curators] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "lymphocyte cell differentiation" EXACT [] synonym: "lymphocyte development" RELATED [GOC:add] synonym: "lymphocytic blood cell differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030099 name: myeloid cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte, megakaryocyte, thrombocyte, or erythrocyte lineages." [GOC:add, ISBN:0781735149] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0030100 name: regulation of endocytosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endocytosis." [GOC:go_curators] is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006897 ! endocytosis [Term] id: GO:0030101 name: natural killer cell activation namespace: biological_process def: "The change in morphology and behavior of a natural killer cell in response to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735140] synonym: "NK cell activation" EXACT [] is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0030103 name: vasopressin secretion namespace: biological_process def: "The regulated release of vasopressin from secretory granules into the blood." [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030104 name: water homeostasis namespace: biological_process alt_id: GO:0018987 def: "Any process involved in the maintenance of an internal steady state of water within an organism or cell." [GOC:dph, GOC:mah, GOC:tb] synonym: "osmoregulation" RELATED [] synonym: "regulation of osmotic pressure" EXACT [] xref: Wikipedia:Osmoregulation is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0030105 name: obsolete anaphylaxis namespace: biological_process def: "OBSOLETE. Extreme immunological sensitivity of the body or tissues to the reintroduction of an antigen. It is a form of anamnestic reaction and is accompanied by pathological changes in tissues or organs due to the release of pharmacologically active substances." [ISBN:0198506732] comment: This term was made obsolete because it represents a an abnormal process that is harmful to the organism. synonym: "anaphylaxis" EXACT [] is_obsolete: true consider: GO:0006955 [Term] id: GO:0030106 name: obsolete MHC class I receptor activity namespace: molecular_function def: "OBSOLETE. A major histocompatibility complex class I receptor. These display processed antigens from the endocytosed bacteria. MHC class I proteins can form complexes with processed antigen peptides only if the antigen is synthesized in the same cell. As a consequence, T lymphocytes can only bind to class-I-positive cells that are synthesizing the antigen (e.g. virus-infected cells)." [ISBN:081533642X, ISBN:0879694971] comment: This term was made obsolete because the definition is ambiguous and contains incorrect information. To update annotations of gene products that act as receptors for MHC class I protein complexes, use the molecular function term 'MHC class I receptor activity ; GO:0032393'; to update annotations of gene products which are components of MHC class I protein complexes, use the cellular component term 'MHC class I protein complex ; GO:0042612'. synonym: "class I major histocompatibility complex antigen" RELATED [] synonym: "major histocompatibility complex class I receptor" EXACT [] synonym: "MHC class I receptor activity" EXACT [] is_obsolete: true consider: GO:0032393 consider: GO:0042612 [Term] id: GO:0030107 name: HLA-A specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030108 name: HLA-A specific activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-A subclass to mediate signaling that activates a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032397 ! activating MHC class I receptor activity [Term] id: GO:0030109 name: HLA-B specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-B subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030110 name: HLA-C specific inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I molecule of the HLA-C subclass to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, GOC:mah, PMID:11929129, PMID:9368779] is_a: GO:0032396 ! inhibitory MHC class I receptor activity [Term] id: GO:0030111 name: regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0008590 def: "Any process that modulates the frequency, rate or extent of the activity of the Wnt signal transduction pathway." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of frizzled signaling pathway" EXACT [] synonym: "regulation of frizzled signalling pathway" EXACT [] synonym: "regulation of Wnt receptor signaling pathway" EXACT [] synonym: "regulation of Wnt receptor signalling pathway" EXACT [] synonym: "regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030112 name: glycocalyx namespace: cellular_component def: "A viscous, carbohydrate rich layer at the outermost periphery of a cell." [GOC:mlg, ISBN:0815316208] subset: goslim_pir synonym: "cell capsule" EXACT [VZ:3896] xref: Wikipedia:Glycocalyx is_a: GO:0030312 ! external encapsulating structure relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0030114 name: slime layer namespace: cellular_component def: "A slime layer is an easily removed, diffuse, unorganized layer of extracellular material that surrounds a cell. Specifically this consists mostly of exopolysaccharides, glycoproteins, and glycolipids." [GOC:mlg, Wikipedia:Slime_layer] xref: Wikipedia:Slime_layer is_a: GO:0030112 ! glycocalyx [Term] id: GO:0030115 name: S-layer namespace: cellular_component def: "A crystalline protein layer surrounding some bacteria." [GOC:mlg, ISBN:0815108893] subset: goslim_pir xref: Wikipedia:S-layer is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0030116 name: glial cell-derived neurotrophic factor receptor binding namespace: molecular_function def: "A growth factor that binds selectively and non-covalently to glial cell-derived neurotrophic factor receptors." [GOC:vw, PMID:11476867] synonym: "glial cell line-derived neurotrophic factor receptor binding" RELATED [] synonym: "glial cell line-derived neurotrophic factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030117 name: membrane coat namespace: cellular_component def: "Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules." [GOC:mah] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0048475 ! coated membrane [Term] id: GO:0030118 name: clathrin coat namespace: cellular_component alt_id: GO:0016190 def: "A membrane coat found on coated pits and some coated vesicles; consists of polymerized clathrin triskelions, each comprising three clathrin heavy chains and three clathrin light chains, linked to the membrane via one of the AP adaptor complexes." [GOC:mah, PMID:11252894, PMID:9531549] synonym: "clathrin cage" EXACT [] xref: NIF_Subcellular:sao879919129 xref: Wikipedia:Clathrin is_a: GO:0030117 ! membrane coat [Term] id: GO:0030119 name: AP-type membrane coat adaptor complex namespace: cellular_component def: "Any of several heterotetrameric complexes that link clathrin (or another coat-forming molecule, as hypothesized for AP-3 and AP-4) to a membrane surface; they are found on coated pits and coated vesicles, and mediate sorting of cargo proteins into vesicles. Each AP complex contains two large (a beta and one of either an alpha, gamma, delta, or epsilon) subunits (110-130 kDa), a medium (mu) subunit (approximately 50 kDa), and a small (sigma) subunit (15-20 kDa)." [GOC:mah, PMID:10611976, PMID:15473838] subset: goslim_pir synonym: "clathrin adaptor" RELATED [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030117 ! membrane coat [Term] id: GO:0030120 name: vesicle coat namespace: cellular_component def: "A membrane coat found on a coated vesicle." [GOC:mah] xref: NIF_Subcellular:sao1177708494 is_a: GO:0030117 ! membrane coat is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030662 ! coated vesicle membrane [Term] id: GO:0030121 name: AP-1 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle; vesicles with AP-1-containing coats are normally found primarily in the trans-Golgi network. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C)." [GOC:mah, PMID:10611976, PMID:21097499] synonym: "HA1" EXACT [] synonym: "HA1 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0030130 ! clathrin coat of trans-Golgi network vesicle [Term] id: GO:0030122 name: AP-2 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC)." [GOC:mah, PMID:10611976, PMID:21097499, PMID:22022230, PMID:24322426] synonym: "HA2" EXACT [] synonym: "HA2 clathrin adaptor" EXACT [] is_a: GO:0030131 ! clathrin adaptor complex is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0030128 ! clathrin coat of endocytic vesicle relationship: part_of GO:0030132 ! clathrin coat of coated pit [Term] id: GO:0030123 name: AP-3 adaptor complex namespace: cellular_component def: "A heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. AP-3 does not appear to associate with clathrin in all organisms. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B)." [GOC:mah, PMID:10611976, PMID:21097499] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030124 name: AP-4 adaptor complex namespace: cellular_component def: "An AP-type membrane coat adaptor complex that consists of beta4, epsilon, mu4 and sigma4 subunits and is found associated with membranes in the trans-Golgi network; it is not clear whether AP-4 forms clathrin coats in vivo." [GOC:mah, PMID:10611976] is_a: GO:0030119 ! AP-type membrane coat adaptor complex [Term] id: GO:0030125 name: clathrin vesicle coat namespace: cellular_component def: "A clathrin coat found on a vesicle." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0030665 ! clathrin-coated vesicle membrane [Term] id: GO:0030126 name: COPI vesicle coat namespace: cellular_component alt_id: GO:0017167 def: "One of two multimeric complexes that forms a membrane vesicle coat. The mammalian COPI subunits are called alpha-, beta-, beta'-, gamma-, delta-, epsilon- and zeta-COP. Vesicles with COPI coats are found associated with Golgi membranes at steady state." [GOC:mah, PMID:11252894] synonym: "coatomer" EXACT [] is_a: GO:0030120 ! vesicle coat is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0030663 ! COPI-coated vesicle membrane [Term] id: GO:0030127 name: COPII vesicle coat namespace: cellular_component def: "One of two multimeric complexes that forms a membrane vesicle coat. COPII is best characterized in S. cerevisiae, where the subunits are called Sar1p, Sec13p, Sec31p, Sec23p, and Sec24p. Vesicles with COPII coats are found associated with endoplasmic reticulum (ER) membranes at steady state." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb, PMID:11252894] is_a: GO:0030120 ! vesicle coat relationship: part_of GO:0012507 ! ER to Golgi transport vesicle membrane [Term] id: GO:0030128 name: clathrin coat of endocytic vesicle namespace: cellular_component def: "A clathrin coat found on an endocytic vesicle." [GOC:mah] synonym: "clathrin coat of endocytotic vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat relationship: part_of GO:0030669 ! clathrin-coated endocytic vesicle membrane [Term] id: GO:0030129 name: clathrin coat of synaptic vesicle namespace: cellular_component def: "A clathrin coat found on a synaptic vesicle." [GOC:mah] is_a: GO:0030125 ! clathrin vesicle coat is_a: GO:0044456 ! synapse part is_a: GO:0097458 ! neuron part relationship: part_of GO:0030672 ! synaptic vesicle membrane [Term] id: GO:0030130 name: clathrin coat of trans-Golgi network vesicle namespace: cellular_component def: "A clathrin coat found on a vesicle of the trans-Golgi network." [GOC:mah] synonym: "clathrin coat of TGN vesicle" EXACT [] is_a: GO:0030125 ! clathrin vesicle coat is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012510 ! trans-Golgi network transport vesicle membrane [Term] id: GO:0030131 name: clathrin adaptor complex namespace: cellular_component def: "A membrane coat adaptor complex that links clathrin to a membrane." [GOC:mah] is_a: GO:0030119 ! AP-type membrane coat adaptor complex relationship: part_of GO:0030118 ! clathrin coat [Term] id: GO:0030132 name: clathrin coat of coated pit namespace: cellular_component def: "The coat found on coated pits and the coated vesicles derived from coated pits; comprises clathrin and the AP-2 adaptor complex." [GOC:mah] is_a: GO:0030118 ! clathrin coat is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005905 ! clathrin-coated pit [Term] id: GO:0030133 name: transport vesicle namespace: cellular_component def: "Any of the vesicles of the constitutive secretory pathway, which carry cargo from the endoplasmic reticulum to the Golgi, between Golgi cisternae, from the Golgi to the ER (retrograde transport) or to destinations within or outside the cell." [GOC:mah, PMID:22160157] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'secretory granule ; GO:0030141'. synonym: "constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi to vacuole transport vesicle" NARROW [] synonym: "Golgi-vacuole transport vesicle" NARROW [] synonym: "secretory vesicle" RELATED [] xref: NIF_Subcellular:sao885490876 is_a: GO:0031410 ! cytoplasmic vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030134 name: COPII-coated ER to Golgi transport vesicle namespace: cellular_component alt_id: GO:0030138 alt_id: GO:0140045 def: "A vesicle with a coat formed of the COPII coat complex proteins. The COPII coat complex is formed by the Sec23p/Sec24p and the Sec13p/Sec31p heterodimers. COPII-associated vesicles transport proteins from the rough endoplasmic reticulum to the Golgi apparatus (anterograde transport)." [PMID:11252894, PMID:17499046, PMID:22160157, PMID:8004676, Wikipedia:COPII] synonym: "COPII vesicle" RELATED [] synonym: "COPII-associated ER to Golgi transport vesicle" EXACT [] synonym: "COPII-associated vesicle" EXACT [] synonym: "COPII-coated vesicle" EXACT [] synonym: "endoplasmic reticulum to Golgi transport vesicle" RELATED [] synonym: "endoplasmic reticulum-Golgi transport vesicle" RELATED [] synonym: "ER to Golgi constitutive secretory pathway transport vesicle" RELATED [] synonym: "ER to Golgi transport vesicle" RELATED [] synonym: "ER-Golgi transport vesicle" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030135 name: coated vesicle namespace: cellular_component alt_id: GO:0005909 def: "Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins." [ISBN:0815316194] xref: NIF_Subcellular:sao1985096626 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030136 name: clathrin-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes." [GOC:mah, PMID:11252894] xref: NIF_Subcellular:sao148845161 is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030137 name: COPI-coated vesicle namespace: cellular_component def: "A vesicle with a coat formed of the COPI coat complex proteins. COPI-coated vesicles are found associated with Golgi membranes at steady state, are involved in Golgi to endoplasmic reticulum (retrograde) vesicle transport, and possibly also in intra-Golgi transport." [GOC:mah, PMID:11252894] synonym: "coatomer" RELATED [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030135 ! coated vesicle [Term] id: GO:0030139 name: endocytic vesicle namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting." [GOC:go_curators, PMID:19696797] synonym: "endocytotic transport vesicle" EXACT [] synonym: "endocytotic vesicle" EXACT [] xref: NIF_Subcellular:sao1362520468 is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0030140 name: trans-Golgi network transport vesicle namespace: cellular_component def: "A vesicle that mediates transport between the trans-Golgi network and other parts of the cell." [GOC:mah] synonym: "TGN transport vesicle" EXACT [] synonym: "trans-Golgi network constitutive secretory pathway transport vesicle" EXACT [] is_a: GO:0005798 ! Golgi-associated vesicle is_a: GO:0030133 ! transport vesicle is_a: GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030141 name: secretory granule namespace: cellular_component def: "A small subcellular vesicle, surrounded by a membrane, that is formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion. Secretory granules move towards the periphery of the cell and upon stimulation, their membranes fuse with the cell membrane, and their protein load is exteriorized. Processing of the contained protein may take place in secretory granules." [GOC:mah, ISBN:0198596732] comment: Note that the term 'secretory vesicle' is sometimes used in this sense, but can also mean 'transport vesicle ; GO:0030133'. synonym: "secretory vesicle" BROAD [] is_a: GO:0099503 ! secretory vesicle relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030142 name: COPI-coated Golgi to ER transport vesicle namespace: cellular_component def: "A vesicle that mediates transport from the Golgi to the endoplasmic reticulum." [GOC:mah, PMID:22160157] synonym: "Golgi to endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi to ER constitutive secretory pathway transport vesicle" EXACT [] synonym: "Golgi-endoplasmic reticulum transport vesicle" EXACT [] synonym: "Golgi-ER transport vesicle" EXACT [] synonym: "retrograde transport vesicle" EXACT [PMID:22160157] is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030143 name: COPI-coated inter-Golgi transport vesicle namespace: cellular_component alt_id: GO:0005807 def: "A vesicle that mediates transport of cargo within the Golgi complex (for example, between cisternae of the Golgi stack)." [GOC:mah] synonym: "inter-Golgi transport constitutive secretory pathway transport vesicle" EXACT [] xref: NIF_Subcellular:sao1382918459 is_a: GO:0030133 ! transport vesicle is_a: GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030144 name: alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl,1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-(N-acetyl-beta-D-glucosaminyl-1,6)-1,2-alpha-D-mannosyl-1,3(6)-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6(3))-beta-D-mannosyl-1,4-N-acetyl-beta-D-glucosaminyl-R. Only branched mannose glycopeptides with non-reducing N-acetylglucosamine terminal residues act as acceptors." [EC:2.4.1.155] synonym: "alpha-1,3(6)-mannosylglycoprotein beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "GnTV activity" EXACT [EC:2.4.1.155] synonym: "N-acetylglucosaminyltransferase V activity" RELATED [EC:2.4.1.155] synonym: "UDP-N-acetyl-D-glucosamine:6-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 6-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta-1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "UDP-N-acetylglucosamine:alpha-mannoside-beta1,6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] synonym: "uridine diphosphoacetylglucosamine-alpha-mannoside beta1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.155] xref: EC:2.4.1.155 xref: MetaCyc:2.4.1.155-RXN xref: reactome:R-HSA-975916 "Addition of GlcNAc to position 5 by MGAT5" xref: RHEA:16921 is_a: GO:0008375 ! acetylglucosaminyltransferase activity is_a: GO:0140103 ! catalytic activity, acting on a glycoprotein [Term] id: GO:0030145 name: manganese ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with manganese (Mn) ions." [GOC:ai] synonym: "manganese binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030146 name: obsolete diuresis namespace: biological_process alt_id: GO:0003076 def: "OBSOLETE. The process of renal water excretion." [GOC:mah, GOC:mtg_cardio, ISBN:0198506732] comment: This term was made obsolete because its definition was inaccurate. synonym: "diuresis" EXACT [] synonym: "positive regulation of renal water excretion" EXACT [] synonym: "renal water excretion" BROAD [] xref: Wikipedia:Diuresis is_obsolete: true consider: GO:0035810 [Term] id: GO:0030147 name: obsolete natriuresis namespace: biological_process def: "OBSOLETE. The process of renal sodium excretion." [GOC:mtg_cardio, ISBN:0198506732] comment: This term was made obsolete because its definition was inaccurate. synonym: "natriuresis" EXACT [] xref: Wikipedia:Natriuresis is_obsolete: true consider: GO:0035815 [Term] id: GO:0030148 name: sphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid anabolism" EXACT [] synonym: "sphingolipid biosynthesis" EXACT [] synonym: "sphingolipid formation" EXACT [] synonym: "sphingolipid synthesis" EXACT [] xref: MetaCyc:PWY-5129 is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0030149 name: sphingolipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732] synonym: "sphingolipid breakdown" EXACT [] synonym: "sphingolipid catabolism" EXACT [] synonym: "sphingolipid degradation" EXACT [] is_a: GO:0006665 ! sphingolipid metabolic process is_a: GO:0046466 ! membrane lipid catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030150 name: protein import into mitochondrial matrix namespace: biological_process def: "The import of proteins across the outer and inner mitochondrial membranes into the matrix. Unfolded proteins enter the mitochondrial matrix with a chaperone protein; the information required to target the precursor protein from the cytosol to the mitochondrial matrix is contained within its N-terminal matrix-targeting sequence. Translocation of precursors to the matrix occurs at the rare sites where the outer and inner membranes are close together." [ISBN:0716731363] synonym: "mitochondrial matrix protein import" EXACT [] synonym: "mitochondrial translocation" BROAD [] synonym: "protein transport into mitochondrial matrix" EXACT [] is_a: GO:0044743 ! protein transmembrane import into intracellular organelle is_a: GO:0065002 ! intracellular protein transmembrane transport is_a: GO:0072655 ! establishment of protein localization to mitochondrion is_a: GO:1990542 ! mitochondrial transmembrane transport relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0030151 name: molybdenum ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdenum (Mo) ions." [GOC:ai] synonym: "molybdenum binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0030152 name: bacteriocin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriocin, any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] synonym: "bacteriocin anabolism" EXACT [] synonym: "bacteriocin biosynthesis" EXACT [] synonym: "bacteriocin formation" EXACT [] synonym: "bacteriocin synthesis" EXACT [] is_a: GO:0009403 ! toxin biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0046224 ! bacteriocin metabolic process [Term] id: GO:0030153 name: bacteriocin immunity namespace: biological_process def: "A process that mediates resistance to a bacteriocin: any of a heterogeneous group of polypeptide antibiotics that are secreted by certain bacterial strains and are able to kill cells of other susceptible (frequently related) strains after adsorption at specific receptors on the cell surface. They include the colicins, and their mechanisms of action vary." [GOC:mah, ISBN:0198506732] is_a: GO:0009404 ! toxin metabolic process [Term] id: GO:0030154 name: cell differentiation namespace: biological_process def: "The process in which relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state." [ISBN:0198506732] subset: goslim_agr subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_plant xref: Wikipedia:Cellular_differentiation is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0030155 name: regulation of cell adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix." [GOC:mah] synonym: "cell adhesion receptor regulator activity" RELATED [] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0007155 ! cell adhesion [Term] id: GO:0030156 name: benzodiazepine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the peripheral benzodiazepine receptor (PBR)." [GOC:ceb, GOC:mah, PMID:9915832] synonym: "benzodiazepine receptor ligand" NARROW [] synonym: "diazepam binding inhibitor activity" RELATED [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030157 name: pancreatic juice secretion namespace: biological_process def: "The regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine. Pancreatic juice is slightly alkaline and contains numerous enzymes and inactive enzyme precursors including alpha-amylase, chymotrypsinogen, lipase, procarboxypeptidase, proelastase, prophospholipase A2, ribonuclease, and trypsinogen. Its high concentration of bicarbonate ions helps to neutralize the acid from the stomach." [GOC:mah, ISBN:0198506732] is_a: GO:0007589 ! body fluid secretion is_a: GO:0022600 ! digestive system process is_a: GO:0032941 ! secretion by tissue [Term] id: GO:0030158 name: protein xylosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a beta-D-xylosyl residue from UDP-D-xylose to the serine hydroxyl group of an acceptor protein substrate." [EC:2.4.2.26] synonym: "peptide O-xylosyltransferase activity" EXACT [] synonym: "UDP-D-xylose:core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:core protein xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "UDP-xylose-core protein beta-D-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-core protein beta-xylosyltransferase activity" EXACT [EC:2.4.2.26] synonym: "uridine diphosphoxylose-protein xylosyltransferase activity" EXACT [EC:2.4.2.26] xref: EC:2.4.2.26 xref: MetaCyc:2.4.2.26-RXN xref: reactome:R-HSA-1878002 "XYLTs transfer Xyl to core protein" is_a: GO:0035252 ! UDP-xylosyltransferase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0030159 name: receptor signaling complex adaptor activity namespace: molecular_function def: "Functions to provide a physical support for the assembly of a multiprotein receptor signaling complex." [GOC:mah] synonym: "receptor signaling complex scaffold activity" EXACT [] synonym: "receptor signaling complex scaffold protein activity" EXACT [] synonym: "receptor signalling complex scaffold activity" EXACT [] is_a: GO:0035591 ! signaling adaptor activity [Term] id: GO:0030160 name: GKAP/Homer scaffold activity namespace: molecular_function def: "Functions as a physical support bridging the N-methyl-D-aspartate receptor-PSD-95-GKAP complex and the mGluR-Homer complex, which are involved in receptor signaling in synapses." [PMID:10506216] synonym: "GKAP/Homer scaffold protein" NARROW [] synonym: "postsynaptic density scaffold protein" NARROW [] is_a: GO:0030159 ! receptor signaling complex adaptor activity [Term] id: GO:0030161 name: obsolete calpain inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme calpain, which catalyzes of the preferential cleavage of Tyr-Xaa, Met-Xaa or Arg-Xaa with Leu or Val as the P2 residue." [GOC:ai] comment: This term was made obsolete because it represents a regulator of a non-existent molecular function. synonym: "calpain inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0010859 [Term] id: GO:0030162 name: regulation of proteolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein." [GOC:mah] synonym: "regulation of peptidolysis" EXACT [] is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0006508 ! proteolysis [Term] id: GO:0030163 name: protein catabolic process namespace: biological_process alt_id: GO:0044254 def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds." [GOC:mah] comment: This term refers to the breakdown of mature proteins. For cleavage events involved in generating a mature protein from a precursor, consider instead the term 'protein maturation ; GO:0051604' and its children. subset: goslim_aspergillus subset: goslim_candida subset: goslim_pombe synonym: "multicellular organismal protein catabolic process" NARROW [] synonym: "pheromone catabolic process" RELATED [] synonym: "pheromone catabolism" RELATED [] synonym: "protein breakdown" EXACT [] synonym: "protein catabolism" EXACT [] synonym: "protein degradation" EXACT [] xref: Wikipedia:Protein_catabolism is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030164 name: protein denaturation namespace: biological_process def: "Structural change in proteins which destroys the native, active configuration without rupture of peptide bonds." [GOC:kd, ISBN:3110145359] xref: Wikipedia:Denaturation#Protein_denaturation is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0030165 name: PDZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a PDZ domain of a protein, a domain found in diverse signaling proteins." [GOC:go_curators, Pfam:PF00595] synonym: "DHR-domain binding" EXACT [] synonym: "GLGF-domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030166 name: proteoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan anabolism" EXACT [] synonym: "proteoglycan biosynthesis" EXACT [] synonym: "proteoglycan formation" EXACT [] synonym: "proteoglycan synthesis" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0030167 name: proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732] synonym: "proteoglycan breakdown" EXACT [] synonym: "proteoglycan catabolism" EXACT [] synonym: "proteoglycan degradation" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0030168 name: platelet activation namespace: biological_process def: "A series of progressive, overlapping events triggered by exposure of the platelets to subendothelial tissue. These events include shape change, adhesiveness, aggregation, and release reactions. When carried through to completion, these events lead to the formation of a stable hemostatic plug." [http://www.graylab.ac.uk/omd/] synonym: "blood coagulation, platelet activation" EXACT [GOC:add, GOC:pde] is_a: GO:0001775 ! cell activation relationship: part_of GO:0007596 ! blood coagulation [Term] id: GO:0030169 name: low-density lipoprotein particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with a low-density lipoprotein particle, a lipoprotein particle that is rich in cholesterol esters and low in triglycerides, is typically composed of APOB100 and APOE, and has a density of 1.02-1.06 g/ml and a diameter of between 20-25 nm." [GOC:mah] subset: goslim_chembl synonym: "LDL binding" EXACT [] is_a: GO:0071813 ! lipoprotein particle binding [Term] id: GO:0030170 name: pyridoxal phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6." [GOC:mah, ISBN:0198506732] subset: goslim_metagenomics is_a: GO:0043168 ! anion binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0070279 ! vitamin B6 binding [Term] id: GO:0030171 name: voltage-gated proton channel activity namespace: molecular_function def: "Enables the transmembrane transfer of a proton by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded." [ISBN:10615049] synonym: "voltage gated proton channel activity" EXACT [] synonym: "voltage-dependent proton channel activity" EXACT [] is_a: GO:0015252 ! proton channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0030172 name: troponin C binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin C, the calcium-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030173 name: integral component of Golgi membrane namespace: cellular_component def: "The component of the Golgi membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:go_curators] synonym: "Golgi integral membrane protein" RELATED [] synonym: "integral to Golgi membrane" NARROW [] is_a: GO:0031228 ! intrinsic component of Golgi membrane is_a: GO:0031301 ! integral component of organelle membrane [Term] id: GO:0030174 name: regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of initiation of DNA-dependent DNA replication; the process in which DNA becomes competent to replicate. In eukaryotes, replication competence is established in early G1 and lost during the ensuing S phase." [GOC:mah] synonym: "DNA replication licencing" EXACT [] synonym: "DNA replication licensing" EXACT [] synonym: "regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0030175 name: filopodium namespace: cellular_component alt_id: GO:0030028 def: "Thin, stiff, actin-based protrusion extended by the leading edge of a motile cell such as a crawling fibroblast or amoeba, or an axonal or dendritic growth cone, or a dendritic shaft." [GOC:mah, GOC:pr, ISBN:0815316194] comment: A filopodium may be approximately 0.1 um wide, 5-10 um long, and up to 50 um long in axon growth cones; contain a loose bundle of about 20 actin filaments oriented with their plus ends pointing outward. Note that filopodia on dendritic shafts are distinct from other types of filopodia (even those found in dendritic growth cones) and may react differently to stimuli, as shown in PMID:12904473. subset: goslim_pir xref: NIF_Subcellular:sao-1046371754 xref: Wikipedia:Filopodia is_a: GO:0098858 ! actin-based cell projection [Term] id: GO:0030176 name: integral component of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "ER integral membrane protein" EXACT [] synonym: "integral to endoplasmic reticulum membrane" NARROW [] synonym: "integral to ER membrane" EXACT [] is_a: GO:0031227 ! intrinsic component of endoplasmic reticulum membrane is_a: GO:0031301 ! integral component of organelle membrane [Term] id: GO:0030177 name: positive regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045811 def: "Any process that activates or increases the frequency, rate or extent of Wnt signal transduction." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "activation of frizzled signaling pathway" NARROW [] synonym: "activation of Wnt receptor signaling pathway" NARROW [] synonym: "positive regulation of frizzled signaling pathway" EXACT [] synonym: "positive regulation of frizzled signalling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signaling pathway" EXACT [] synonym: "positive regulation of Wnt receptor signalling pathway" EXACT [] synonym: "positive regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] synonym: "stimulation of frizzled signaling pathway" NARROW [] synonym: "stimulation of Wnt receptor signaling pathway" NARROW [] synonym: "up regulation of frizzled signaling pathway" EXACT [] synonym: "up regulation of Wnt receptor signaling pathway" EXACT [] synonym: "up-regulation of frizzled signaling pathway" EXACT [] synonym: "up-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "upregulation of frizzled signaling pathway" EXACT [] synonym: "upregulation of Wnt receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway relationship: positively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030178 name: negative regulation of Wnt signaling pathway namespace: biological_process alt_id: GO:0045810 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the Wnt signaling pathway." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of frizzled signaling pathway" EXACT [] synonym: "down regulation of Wnt receptor signaling pathway" EXACT [] synonym: "down-regulation of frizzled signaling pathway" EXACT [] synonym: "down-regulation of Wnt receptor signaling pathway" EXACT [] synonym: "downregulation of frizzled signaling pathway" EXACT [] synonym: "downregulation of Wnt receptor signaling pathway" EXACT [] synonym: "inhibition of frizzled signaling pathway" NARROW [] synonym: "inhibition of Wnt receptor signaling pathway" NARROW [] synonym: "negative regulation of frizzled signaling pathway" EXACT [] synonym: "negative regulation of frizzled signalling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signaling pathway" EXACT [] synonym: "negative regulation of Wnt receptor signalling pathway" EXACT [] synonym: "negative regulation of Wnt-activated signaling pathway" EXACT [GOC:signaling] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030111 ! regulation of Wnt signaling pathway relationship: negatively_regulates GO:0016055 ! Wnt signaling pathway [Term] id: GO:0030180 name: obsolete solute:solute exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion of two solutes between the inside and outside of a cell or subcellular compartment, in which movement of one solute down a concentration gradient drives movement of the other solute in the opposite direction." [GOC:mah] comment: This term was made obsolete because it represents a molecular function. synonym: "solute:solute exchange" EXACT [] is_obsolete: true consider: GO:0006810 consider: GO:0015297 [Term] id: GO:0030181 name: obsolete sodium:calcium exchange namespace: biological_process def: "OBSOLETE. Exchange diffusion sodium and calcium ions in which influx of sodium ions to the cytosol drives the efflux of calcium ions from the cell." [GOC:mah, ISBN:0198506732] comment: This term was made obsolete because it represents a function rather than a process. synonym: "sodium:calcium exchange" EXACT [] is_obsolete: true consider: GO:0005432 consider: GO:0006814 consider: GO:0006816 [Term] id: GO:0030182 name: neuron differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a neuron." [GOC:mah] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0030183 name: B cell differentiation namespace: biological_process alt_id: GO:0042115 def: "The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity." [GO_REF:0000022, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "B cell development" RELATED [GOC:add] synonym: "B lymphocyte differentiation" EXACT [] synonym: "B-cell differentiation" EXACT [] synonym: "B-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042113 ! B cell activation [Term] id: GO:0030184 name: nitric oxide transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of nitric oxide, nitrogen monoxide, from one side of a membrane to the other." [GOC:mah] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0015318 ! inorganic molecular entity transmembrane transporter activity [Term] id: GO:0030185 name: nitric oxide transport namespace: biological_process def: "The directed movement of nitric oxide, nitrogen monoxide, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0015893 ! drug transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0030186 name: melatonin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin metabolism" EXACT [] is_a: GO:0017144 ! drug metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042430 ! indole-containing compound metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0030187 name: melatonin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melatonin (N-acetyl-5-methoxytryptamine)." [GOC:mah, ISBN:0198506732] synonym: "melatonin anabolism" EXACT [] synonym: "melatonin biosynthesis" EXACT [] synonym: "melatonin formation" EXACT [] synonym: "melatonin synthesis" EXACT [] is_a: GO:0030186 ! melatonin metabolic process is_a: GO:0042435 ! indole-containing compound biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0030188 name: obsolete chaperone regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone regulator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030189 name: obsolete chaperone activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone activator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030190 name: obsolete chaperone inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of a molecular chaperone." [GOC:mah] comment: This term was made obsolete because it refers to a obsolete molecular function term, 'chaperone activity'. synonym: "chaperone inhibitor activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030191 name: obsolete Hsp70/Hsc70 protein inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. synonym: "Hsp70/Hsc70 protein inhibitor activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030192 name: obsolete Hsp70/Hsc70 protein regulator activity namespace: molecular_function def: "OBSOLETE. Modulates the activity of chaperones of the Hsp70/Hsc70 class." [GOC:mah] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'Hsp70/Hsc70 protein activity'. synonym: "Hsp70/Hsc70 protein regulator activity" EXACT [] is_obsolete: true consider: GO:0006457 consider: GO:0051082 consider: GO:0051787 [Term] id: GO:0030193 name: regulation of blood coagulation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of blood coagulation." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0050818 ! regulation of coagulation is_a: GO:0061041 ! regulation of wound healing is_a: GO:1900046 ! regulation of hemostasis relationship: regulates GO:0007596 ! blood coagulation [Term] id: GO:0030194 name: positive regulation of blood coagulation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "activation of blood coagulation" NARROW [] synonym: "stimulation of blood coagulation" NARROW [] synonym: "up regulation of blood coagulation" EXACT [] synonym: "up-regulation of blood coagulation" EXACT [] synonym: "upregulation of blood coagulation" EXACT [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050820 ! positive regulation of coagulation is_a: GO:0090303 ! positive regulation of wound healing is_a: GO:1900048 ! positive regulation of hemostasis relationship: positively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030195 name: negative regulation of blood coagulation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation." [GOC:mah] synonym: "down regulation of blood coagulation" EXACT [] synonym: "down-regulation of blood coagulation" EXACT [] synonym: "downregulation of blood coagulation" EXACT [] synonym: "inhibition of blood coagulation" NARROW [] is_a: GO:0030193 ! regulation of blood coagulation is_a: GO:0050819 ! negative regulation of coagulation is_a: GO:0061045 ! negative regulation of wound healing is_a: GO:1900047 ! negative regulation of hemostasis relationship: negatively_regulates GO:0007596 ! blood coagulation [Term] id: GO:0030196 name: cyanide hydratase activity namespace: molecular_function def: "Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide." [EC:4.2.1.66, RHEA:21720] synonym: "formamide dehydratase activity" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase (cyanide-forming)" EXACT [EC:4.2.1.66] synonym: "formamide hydro-lyase activity" EXACT [EC:4.2.1.66] xref: EC:4.2.1.66 xref: KEGG:R01408 xref: MetaCyc:CYANIDE-HYDRATASE-RXN xref: RHEA:21720 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030197 name: extracellular matrix constituent, lubricant activity namespace: molecular_function def: "Functions as a lubricant for an extracellular matrix, such as a mucous membrane." [GOC:mah] comment: Extracellular matrix mucin proteins may be annotated to this term. PMID:14711375, PMID:18601586 synonym: "core extracellular matrix" BROAD [] synonym: "core matrisome" BROAD [] is_a: GO:0005201 ! extracellular matrix structural constituent [Term] id: GO:0030198 name: extracellular matrix organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an extracellular matrix." [GOC:mah] subset: goslim_chembl subset: goslim_generic synonym: "extracellular matrix organisation" EXACT [GOC:curators] synonym: "extracellular matrix organization and biogenesis" RELATED [GOC:mah] is_a: GO:0043062 ! extracellular structure organization [Term] id: GO:0030199 name: collagen fibril organization namespace: biological_process def: "Any process that determines the size and arrangement of collagen fibrils within an extracellular matrix." [GOC:mah, ISBN:0815316194] synonym: "collagen fibril organisation" EXACT [GOC:curators] synonym: "fibrillar collagen organization" EXACT [GOC:mah] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0043933 ! protein-containing complex subunit organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0030200 name: heparan sulfate proteoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4) linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate proteoglycan breakdown" EXACT [] synonym: "heparan sulfate proteoglycan catabolism" EXACT [] synonym: "heparan sulfate proteoglycan degradation" EXACT [] synonym: "heparan sulphate proteoglycan catabolic process" EXACT [] synonym: "heparan sulphate proteoglycan catabolism" EXACT [] synonym: "heparin proteoglycan catabolic process" RELATED [] is_a: GO:0030167 ! proteoglycan catabolic process is_a: GO:0030201 ! heparan sulfate proteoglycan metabolic process [Term] id: GO:0030201 name: heparan sulfate proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any proteoglycan containing heparan sulfate, any member of a group of glycosaminoglycans that have repeat units consisting of alternating alpha-(1->4)-linked hexuronic acid and glucosamine residues, the former being a mixture of sulfated and nonsulfated D-glucuronic and L-iduronic acids, and the latter being either sulfated or acetylated on its amino group as well as sulfated on one of its hydroxyl groups." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate proteoglycan metabolism" EXACT [] synonym: "heparan sulphate proteoglycan metabolic process" EXACT [] synonym: "heparan sulphate proteoglycan metabolism" EXACT [] synonym: "heparin proteoglycan metabolic process" RELATED [] is_a: GO:0006029 ! proteoglycan metabolic process [Term] id: GO:0030202 name: heparin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells. They are similar to heparan sulfates but are of somewhat higher average Mr (6000-20000) and contain fewer N-acetyl groups and more N-sulfate and O-sulfate groups; they may be attached in the same manner to protein, forming proteoglycans. They consist predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate metabolic process" RELATED [] synonym: "heparin metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0030203 name: glycosaminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars. Formerly known as mucopolysaccharides, they include hyaluronic acid and chondroitin, which provide lubrication in joints and form part of the matrix of cartilage. The three-dimensional structure of these molecules enables them to trap water, which forms a gel and gives glycosaminoglycans their elastic properties." [ISBN:0192800981] synonym: "glycosaminoglycan metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0030204 name: chondroitin sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate. They usually occur linked to a protein to form proteoglycans. Two subgroups exist, one in which the sulfate is on the 4-position (chondroitin sulfate A) and the second in which it is in the 6-position (chondroitin sulfate C). They often are polydisperse and often differ in the degree of sulfation from tissue to tissue. The chains of repeating disaccharide are covalently linked to the side chains of serine residues in the polypeptide backbone of a protein by a glycosidic attachment through the trisaccharide unit galactosyl-galactosyl-xylosyl. Chondroitin sulfate B is more usually known as dermatan sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate metabolism" EXACT [] synonym: "chondroitin sulphate metabolic process" EXACT [] synonym: "chondroitin sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0043436 ! oxoacid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process relationship: part_of GO:0050654 ! chondroitin sulfate proteoglycan metabolic process [Term] id: GO:0030205 name: dermatan sulfate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units. They are important components of ground substance or intercellular cement of skin and some connective tissues." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B metabolic process" EXACT [] synonym: "chondroitin sulfate B metabolism" EXACT [] synonym: "dermatan sulfate metabolism" EXACT [] synonym: "dermatan sulphate metabolic process" EXACT [] synonym: "dermatan sulphate metabolism" EXACT [] is_a: GO:0006790 ! sulfur compound metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process relationship: part_of GO:0050655 ! dermatan sulfate proteoglycan metabolic process [Term] id: GO:0030206 name: chondroitin sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate anabolism" EXACT [] synonym: "chondroitin sulfate biosynthesis" EXACT [] synonym: "chondroitin sulfate formation" EXACT [] synonym: "chondroitin sulfate synthesis" EXACT [] synonym: "chondroitin sulphate biosynthesis" EXACT [] synonym: "chondroitin sulphate biosynthetic process" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process relationship: part_of GO:0050650 ! chondroitin sulfate proteoglycan biosynthetic process [Term] id: GO:0030207 name: chondroitin sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chondroitin sulfate, any member of a group of 10-60 kDa glycosaminoglycans, widely distributed in cartilage and other mammalian connective tissues, the repeat units of which consist of beta-(1,4)-linked D-glucuronyl beta-(1,3)-N-acetyl-D-galactosamine sulfate." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate breakdown" EXACT [] synonym: "chondroitin sulfate catabolism" EXACT [] synonym: "chondroitin sulfate degradation" EXACT [] synonym: "chondroitin sulphate catabolic process" EXACT [] synonym: "chondroitin sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030204 ! chondroitin sulfate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030208 name: dermatan sulfate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dermatan sulfate, any glycosaminoglycan with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B biosynthesis" EXACT [] synonym: "chondroitin sulfate B biosynthetic process" EXACT [] synonym: "dermatan sulfate anabolism" EXACT [] synonym: "dermatan sulfate biosynthesis" EXACT [] synonym: "dermatan sulfate formation" EXACT [] synonym: "dermatan sulfate synthesis" EXACT [] synonym: "dermatan sulphate biosynthesis" EXACT [] synonym: "dermatan sulphate biosynthetic process" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process relationship: part_of GO:0050651 ! dermatan sulfate proteoglycan biosynthetic process [Term] id: GO:0030209 name: dermatan sulfate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dermatan sulfate, any of a group of glycosaminoglycans with repeats consisting of beta-(1,4)-linked L-iduronyl-beta-(1,3)-N-acetyl-D-galactosamine 4-sulfate units." [GOC:mah, ISBN:0198506732] synonym: "chondroitin sulfate B catabolic process" EXACT [] synonym: "chondroitin sulfate B catabolism" EXACT [] synonym: "dermatan sulfate breakdown" EXACT [] synonym: "dermatan sulfate catabolism" EXACT [] synonym: "dermatan sulfate degradation" EXACT [] synonym: "dermatan sulphate catabolic process" EXACT [] synonym: "dermatan sulphate catabolism" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030205 ! dermatan sulfate metabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0030210 name: heparin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate biosynthetic process" RELATED [] synonym: "heparin anabolism" EXACT [] synonym: "heparin biosynthesis" EXACT [] synonym: "heparin formation" EXACT [] synonym: "heparin synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0030211 name: heparin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of heparin, any member of a group of glycosaminoglycans of average Mr (6000-20000), consisting predominantly of alternating alpha-(1->4)-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:mah, ISBN:0198506732] synonym: "heparan sulfate catabolic process" RELATED [] synonym: "heparin breakdown" EXACT [] synonym: "heparin catabolism" EXACT [] synonym: "heparin degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030202 ! heparin metabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0030212 name: hyaluronan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:1903510 ! mucopolysaccharide metabolic process [Term] id: GO:0030213 name: hyaluronan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan anabolism" EXACT [] synonym: "hyaluronan biosynthesis" EXACT [] synonym: "hyaluronan formation" EXACT [] synonym: "hyaluronan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0030212 ! hyaluronan metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0030214 name: hyaluronan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine." [GOC:mah, ISBN:0198506732] synonym: "hyaluronan breakdown" EXACT [] synonym: "hyaluronan catabolism" EXACT [] synonym: "hyaluronan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0030212 ! hyaluronan metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0030215 name: semaphorin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with semaphorin receptors." [GOC:ceb, PMID:12001990] synonym: "plexin binding" NARROW [] synonym: "plexin ligand" NARROW [] synonym: "semaphorin receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030216 name: keratinocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a keratinocyte." [GOC:dph, GOC:mah, GOC:sdb_2009, GOC:tb] synonym: "keratinocyte cell differentiation" EXACT [] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0043588 ! skin development [Term] id: GO:0030217 name: T cell differentiation namespace: biological_process alt_id: GO:0042112 alt_id: GO:0046652 def: "The process in which a precursor cell type acquires characteristics of a more mature T-cell. A T cell is a type of lymphocyte whose definin characteristic is the expression of a T cell receptor complex." [GO_REF:0000022, GOC:jid, GOC:mah, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was moved. Note that the term 'thymocyte differentiation' was merged into this term because thymocytes are T cells, and thus the term was essentially redundant. Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development" RELATED [GOC:add] synonym: "T lymphocyte differentiation" EXACT [] synonym: "T-cell differentiation" EXACT [] synonym: "T-lymphocyte differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0042110 ! T cell activation [Term] id: GO:0030218 name: erythrocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of an erythrocyte." [GOC:mah] synonym: "erythrocyte cell differentiation" EXACT [] synonym: "erythropoiesis" EXACT [GOC:add, GOC:dph] synonym: "RBC differentiation" EXACT [CL:0000232] synonym: "red blood cell differentiation" EXACT [CL:0000232] xref: Wikipedia:Erythropoiesis is_a: GO:0030099 ! myeloid cell differentiation relationship: part_of GO:0034101 ! erythrocyte homeostasis [Term] id: GO:0030219 name: megakaryocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires specializes features of a megakaryocyte." [GOC:mah] synonym: "megakaryocyte cell differentiation" EXACT [] is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0030220 name: platelet formation namespace: biological_process def: "The process in which platelets bud from long processes extended by megakaryocytes." [GOC:mah, ISBN:0815316194] synonym: "platelet extrusion" EXACT systematic_synonym [GOC:curators] is_a: GO:0030099 ! myeloid cell differentiation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0036344 ! platelet morphogenesis [Term] id: GO:0030221 name: basophil differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires specialized features of a basophil cell." [GOC:jid, GOC:mah] synonym: "basophil cell differentiation" EXACT [] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030222 name: eosinophil differentiation namespace: biological_process alt_id: GO:0035856 def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specializes features of an eosinophil." [GOC:add, GOC:mah] synonym: "eosinophil cell development" RELATED [GOC:bf] synonym: "eosinophil cell differentiation" EXACT [] synonym: "eosinophil development" RELATED [] is_a: GO:0030851 ! granulocyte differentiation is_a: GO:0048468 ! cell development [Term] id: GO:0030223 name: neutrophil differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a neutrophil." [GOC:mah] synonym: "neutrophil cell differentiation" EXACT [] synonym: "neutrophil granulocyte differentiation" EXACT [GOC:yaf] synonym: "neutrophil granulocytopoiesis" EXACT [GOC:yaf] is_a: GO:0030851 ! granulocyte differentiation [Term] id: GO:0030224 name: monocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized myeloid precursor cell acquires the specialized features of a monocyte." [GOC:mah] synonym: "monocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation is_a: GO:1903131 ! mononuclear cell differentiation [Term] id: GO:0030225 name: macrophage differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of a macrophage." [GOC:add, ISBN:0781735149] synonym: "macrophage cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030226 name: apolipoprotein receptor activity namespace: molecular_function def: "Combining with an apolipoprotein to initiate a change in cell activity." [GOC:mah, ISBN:0198506732] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0030227 name: obsolete apolipoprotein E receptor activity namespace: molecular_function def: "OBSOLETE. Combining with apolipoprotein E to initiate a change in cell activity." [GOC:mah] comment: This term was made obsolete because no known receptor binds apolipoprotein E; instead, receptors bind holo-lipoprotein E (apolipoprotein E + bound lipid). synonym: "ApoE receptor" EXACT [] synonym: "apolipoprotein E receptor activity" EXACT [] is_obsolete: true replaced_by: GO:0030229 [Term] id: GO:0030228 name: lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a lipoprotein particle and delivering the lipoprotein particle into the cell via endocytosis. A lipoprotein particle, also known as a lipoprotein, is a clathrate complex consisting of a lipid enwrapped in a protein host without covalent binding in such a way that the complex has a hydrophilic outer surface consisting of all the protein and the polar ends of any phospholipids." [CHEBI:6495, GOC:bf, GOC:mah, PMID:12827279] comment: This term is intended for cell surface receptors that bind and internalize a lipoprotein particle. For members of the lipoprotein receptor family that transduce a signal rather than endocytose their ligand, consider instead the terms 'signaling receptor activity ; GO:0038023' and its children, or 'reelin receptor activity ; GO:0038025'. synonym: "lipoprotein receptor activity" EXACT [GOC:dph] synonym: "plasma lipoprotein particle receptor activity" NARROW [GOC:BHF] is_a: GO:0038024 ! cargo receptor activity [Term] id: GO:0030229 name: very-low-density lipoprotein particle receptor activity namespace: molecular_function def: "Combining with a very-low-density lipoprotein particle and delivering the very-low-density lipoprotein into the cell via endocytosis." [GOC:bf, ISBN:0198506732] synonym: "apolipoprotein E receptor activity" RELATED [GOC:rl] synonym: "very-low-density lipoprotein receptor activity" EXACT [GOC:dph] synonym: "VLDL receptor" EXACT [] xref: Wikipedia:VLDL_receptor is_a: GO:0030228 ! lipoprotein particle receptor activity [Term] id: GO:0030232 name: insulin control element activator complex namespace: cellular_component def: "Transcription factor complex that binds to the insulin control element (ICE), a DNA sequence element found within the 5'-flanking region of the insulin gene, and activates ICE-mediated transcription." [PMID:7935390] synonym: "ICE activator complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0030233 name: deoxynucleotide transmembrane transporter activity namespace: molecular_function def: "Catalyzes transport of all four deoxy (d) NDPs, and, less efficiently, the corresponding dNTPs, in exchange for dNDPs, ADP, or ATP." [PMID:11226231] is_a: GO:0015215 ! nucleotide transmembrane transporter activity [Term] id: GO:0030234 name: enzyme regulator activity namespace: molecular_function alt_id: GO:0010576 def: "Binds to and modulates the activity of an enzyme." [GOC:dph, GOC:mah, GOC:tb] comment: GO:0030234 is reserved for cases when the regulator directly interacts with the enzyme. When regulation of enzyme activity is achieved without enzyme binding, or when the mechanism of regulation is unknown, instead annotate to 'regulation of catalytic activity ; GO:0050790'. subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "catalytic regulator activity" EXACT [GOC:dph] synonym: "enzyme modulator" EXACT [] synonym: "metalloenzyme regulator activity" NARROW [] is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0030235 name: nitric-oxide synthase regulator activity namespace: molecular_function def: "Modulates the activity of nitric oxide synthase." [GOC:mah] comment: See also 'regulation of nitric-oxide synthase activity ; GO:0050999'. synonym: "nitric oxide synthase regulator activity" EXACT [] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0030237 name: female sex determination namespace: biological_process def: "The specification of female sex of an individual organism." [GOC:mah, ISBN:0198506732] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0030238 name: male sex determination namespace: biological_process def: "The specification of male sex of an individual organism." [GOC:mah] is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organism development [Term] id: GO:0030239 name: myofibril assembly namespace: biological_process def: "Formation of myofibrils, the repeating units of striated muscle." [GOC:mah] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0070925 ! organelle assembly is_a: GO:0097435 ! supramolecular fiber organization relationship: part_of GO:0055002 ! striated muscle cell development [Term] id: GO:0030240 name: skeletal muscle thin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the actin-based thin filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0007015 ! actin filament organization relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030241 name: skeletal muscle myosin thick filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins to form the myosin-based thick filaments of myofibrils in skeletal muscle." [GOC:ef, GOC:mah, GOC:mtg_muscle] is_a: GO:0071688 ! striated muscle myosin thick filament assembly relationship: part_of GO:0014866 ! skeletal myofibril assembly [Term] id: GO:0030242 name: autophagy of peroxisome namespace: biological_process def: "The process in which peroxisomes are delivered to the vacuole and degraded in response to changing nutrient conditions." [GOC:autophagy, PMID:10547367, PMID:20083110] synonym: "peroxisome degradation" BROAD [] synonym: "pexophagy" RELATED [] is_a: GO:0006914 ! autophagy [Term] id: GO:0030243 name: cellulose metabolic process namespace: biological_process alt_id: GO:0016177 def: "The chemical reactions and pathways involving cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0030244 name: cellulose biosynthetic process namespace: biological_process alt_id: GO:0016178 def: "The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose anabolism" EXACT [] synonym: "cellulose biosynthesis" EXACT [] synonym: "cellulose formation" EXACT [] synonym: "cellulose synthesis" EXACT [] xref: MetaCyc:PWY-1001 is_a: GO:0030243 ! cellulose metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0030245 name: cellulose catabolic process namespace: biological_process alt_id: GO:0016179 def: "The chemical reactions and pathways resulting in the breakdown of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation." [GOC:mah, ISBN:0198506732] synonym: "cellulose breakdown" EXACT [] synonym: "cellulose catabolism" EXACT [] synonym: "cellulose degradation" EXACT [] is_a: GO:0030243 ! cellulose metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0030246 name: carbohydrate binding namespace: molecular_function alt_id: GO:0005529 def: "Interacting selectively and non-covalently with any carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates." [CHEBI:16646, GOC:mah] subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_metagenomics subset: goslim_pir subset: goslim_plant synonym: "selectin" RELATED [] synonym: "sugar binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0030247 name: polysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with any polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically." [CHEBI:18154, GOC:mah] is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0030248 name: cellulose binding namespace: molecular_function def: "Interacting selectively and non-covalently with cellulose." [GOC:mah] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0030249 name: guanylate cyclase regulator activity namespace: molecular_function def: "Modulates the activity of guanylate cyclase." [GOC:mah] is_a: GO:0010851 ! cyclase regulator activity [Term] id: GO:0030250 name: guanylate cyclase activator activity namespace: molecular_function def: "Binds to and increases the activity of guanylate cyclase." [GOC:mah] synonym: "guanylin" NARROW [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0010853 ! cyclase activator activity is_a: GO:0030249 ! guanylate cyclase regulator activity [Term] id: GO:0030251 name: guanylate cyclase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of guanylate cyclase." [GOC:mah] is_a: GO:0010852 ! cyclase inhibitor activity is_a: GO:0030249 ! guanylate cyclase regulator activity [Term] id: GO:0030252 name: growth hormone secretion namespace: biological_process def: "The regulated release of growth hormone from secretory granules into the blood." [GOC:mah] synonym: "somatotropin secretion" EXACT [GOC:mah] is_a: GO:0030072 ! peptide hormone secretion [Term] id: GO:0030253 name: protein secretion by the type I secretion system namespace: biological_process def: "The process in which proteins are secreted into the extracellular milieu via the type I secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type I protein secretion system complex ; GO:0030256'. synonym: "protein secretion by the TOSS" EXACT [] synonym: "protein secretion by the type I protein secretion system" EXACT [] synonym: "type I protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030254 name: protein secretion by the type III secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the bacterial type III secretion system; secretion occurs in a continuous process without the distinct presence of periplasmic intermediates and does not involve proteolytic processing of secreted proteins." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type III protein secretion system complex ; GO:0030257'. Note that this term is used for annotation of proteins that compose the secretion complex but not the proteins being secreted. synonym: "protein secretion by the T3S" EXACT [] synonym: "protein secretion by the T3SS" EXACT [] synonym: "protein secretion by the TTSS" EXACT [] synonym: "protein secretion by the type III protein secretion system" EXACT [] synonym: "type III protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030255 name: protein secretion by the type IV secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells, via the type IV protein secretion system." [GOC:pamgo_curators] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type IV protein secretion system complex ; GO:0043684'. synonym: "protein secretion by the T4SS" EXACT [] synonym: "protein secretion by the type IV protein secretion system" EXACT [] synonym: "type IV protein secretion system" NARROW [] is_a: GO:0009306 ! protein secretion is_a: GO:0044097 ! secretion by the type IV secretion system is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0030256 name: type I protein secretion system complex namespace: cellular_component def: "A complex of three secretory proteins that carry out secretion in the type I secretion system: an inner membrane transport ATPase (termed ABC protein for ATP-binding cassette), which provides the energy for protein secretion; an outer membrane protein, which is exported via the sec pathway; and a membrane fusion protein, which is anchored in the inner membrane and spans the periplasmic space." [PMID:9618447] synonym: "ABC translocator complex" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0030257 name: type III protein secretion system complex namespace: cellular_component def: "A complex of approximately 20 proteins, most of which are located in the cytoplasmic membrane that carries out protein secretion in the bacterial type III secretion system; type III secretion also requires a cytoplasmic, probably membrane-associated ATPase." [PMID:9618447] synonym: "T3SS complex" EXACT [] synonym: "TTSS complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0030258 name: lipid modification namespace: biological_process def: "The covalent alteration of one or more fatty acids in a lipid, resulting in a change in the properties of the lipid." [GOC:mah] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0030259 name: lipid glycosylation namespace: biological_process def: "Covalent attachment of a glycosyl residue to a lipid molecule." [GOC:mah] is_a: GO:0030258 ! lipid modification is_a: GO:0070085 ! glycosylation [Term] id: GO:0030260 name: entry into host cell namespace: biological_process def: "The invasion by an organism of a cell of its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:njm] synonym: "host cell invasion" EXACT [] is_a: GO:0044409 ! entry into host is_a: GO:0051806 ! entry into cell of other organism involved in symbiotic interaction [Term] id: GO:0030261 name: chromosome condensation namespace: biological_process alt_id: GO:0000068 def: "The progressive compaction of dispersed interphase chromatin into threadlike chromosomes prior to mitotic or meiotic nuclear division, or during apoptosis, in eukaryotic cells." [GOC:mah, ISBN:0815316194] synonym: "DNA condensation" BROAD [Wikipedia:DNA_condensation] synonym: "eukaryotic chromosome condensation" EXACT [GOC:bf] synonym: "nuclear chromosome condensation" EXACT [GOC:bf] is_a: GO:0006323 ! DNA packaging [Term] id: GO:0030262 name: apoptotic nuclear changes namespace: biological_process def: "Alterations undergone by nuclei at the molecular and morphological level as part of the execution phase of apoptosis." [GOC:mah, GOC:mtg_apoptosis] synonym: "apoptotic nuclear change" NARROW [] is_a: GO:0006921 ! cellular component disassembly involved in execution phase of apoptosis [Term] id: GO:0030263 name: apoptotic chromosome condensation namespace: biological_process def: "The compaction of chromatin during apoptosis." [GOC:mah] synonym: "pyknosis" EXACT [] xref: Wikipedia:Pyknosis is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030264 name: nuclear fragmentation involved in apoptotic nuclear change namespace: biological_process def: "The breakdown of the nucleus into small membrane-bounded compartments, or blebs, each of which contain compacted DNA." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0721639976] synonym: "apoptotic nuclear fragmentation" EXACT [] synonym: "nuclear fragmentation during apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "nucleus fragmentation" EXACT [] is_a: GO:0071763 ! nuclear membrane organization relationship: part_of GO:0030262 ! apoptotic nuclear changes [Term] id: GO:0030265 name: phospholipase C-activating rhodopsin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a rhodopsin molecule being activated by a photon, where the pathway proceeds with activation of phospholipase C (PLC) and a subsequent release of inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:mah, GOC:signaling, PMID:22498302, PMID:8823931] synonym: "phospholipase C-activating rhodopsin mediated G-protein coupled receptor signaling pathway" EXACT [GOC:bf] synonym: "PLC-activating rhodopsin mediated signaling pathway" EXACT [GOC:bf] synonym: "rhodopsin mediated G protein signaling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G protein signalling, coupled to IP3 second messenger" EXACT [] synonym: "rhodopsin mediated G-protein signaling, coupled to IP3 second messenger" EXACT [GOC:signaling] synonym: "rhodopsin mediated G-protein signalling, coupled to IP3 second messenger" EXACT [] is_a: GO:0007200 ! phospholipase C-activating G protein-coupled receptor signaling pathway is_a: GO:0016056 ! rhodopsin mediated signaling pathway [Term] id: GO:0030266 name: quinate 3-dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: (-)-quinate + NAD+ = (-)-3-dehydroquinate + NADH + H+." [EC:1.1.1.24] synonym: "quinate:NAD 3-oxidoreductase activity" EXACT [] synonym: "quinate:NAD 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinate:NAD(+) 3-oxidoreductase activity" EXACT [] synonym: "quinate:NAD(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.24] synonym: "quinic dehydrogenase activity" BROAD [EC:1.1.1.24] xref: EC:1.1.1.24 xref: EC:1.1.1.282 xref: KEGG:R01872 xref: MetaCyc:QUINATE-5-DEHYDROGENASE-RXN xref: RHEA:22364 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030267 name: glyoxylate reductase (NADP) activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + NADP+ = glyoxylate + NADPH + H+." [EC:1.1.1.79] synonym: "glycolate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.79] synonym: "glyoxylate reductase (NADP+)" EXACT [EC:1.1.1.79] synonym: "NADPH-glyoxylate reductase activity" EXACT [EC:1.1.1.79] xref: EC:1.1.1.79 xref: MetaCyc:GLYOXYLATE-REDUCTASE-NADP+-RXN xref: reactome:R-HSA-389826 "glyoxylate + NADPH + H+ => glycolate + NADP+" xref: RHEA:10992 xref: Wikipedia:Glyoxylate_reductase_(NADP+) is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030268 name: methylenetetrahydromethanopterin dehydrogenase activity namespace: molecular_function alt_id: GO:0018536 def: "Catalysis of the reaction: 5,10-methylenetetrahydromethanopterin + coenzyme F420 + 2 H(+) = 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + reduced coenzyme F420." [EC:1.5.99.9, RHEA:16721] synonym: "5,10-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] synonym: "5,10-methylenetetrahydromethanopterin:coenzyme-F420 oxidoreductase activity" EXACT [EC:1.5.99.9] synonym: "N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase activity" EXACT [EC:1.5.99.9] xref: EC:1.5.99.9 xref: KEGG:R04456 xref: MetaCyc:1.5.99.9-RXN xref: RHEA:16721 xref: UM-BBD_reactionID:r0348 is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0030269 name: tetrahydromethanopterin S-methyltransferase activity namespace: molecular_function alt_id: GO:0018709 def: "Catalysis of the reaction: 5-methyltetrahydromethanopterin + coenzyme M = 5,6,7,8-tetrahydromethanopterin + methyl-coenzyme M. 2-(methylthio)ethanesulfonate is also known as methyl-CoM." [EC:2.1.1.86, RHEA:17588] synonym: "5-methyl-5,6,7,8-tetrahydromethanopterin:2-mercaptoethanesulfonate 2-methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N(5)-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "N5-methyltetrahydromethanopterin--coenzyme M methyltransferase activity" EXACT [EC:2.1.1.86] synonym: "tetrahydromethanopterin methyltransferase activity" EXACT [EC:2.1.1.86] xref: EC:2.1.1.86 xref: KEGG:R04347 xref: MetaCyc:2.1.1.86-RXN xref: RHEA:17588 xref: UM-BBD_reactionID:r0355 is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042086 ! 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity [Term] id: GO:0030270 name: formylmethanofuran-tetrahydromethanopterin N-formyltransferase activity namespace: molecular_function alt_id: GO:0018714 def: "Catalysis of the reaction: 5,6,7,8-tetrahydromethanopterin + N-formylmethanofuran + H(+) = N(5)-formyl-5,6,7,8-tetrahydromethanopterin + methanofuran." [EC:2.3.1.101, RHEA:18061] synonym: "formylmethanofuran-tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin 5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:5,6,7,8-tetrahydromethanopterin N5-formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "formylmethanofuran:tetrahydromethanopterin formyltransferase activity" EXACT [EC:2.3.1.101] synonym: "FTR" RELATED [EC:2.3.1.101] synonym: "N-formylmethanofuran(CHO-MFR):tetrahydromethanopterin(H4MPT) formyltransferase activity" EXACT [EC:2.3.1.101] xref: EC:2.3.1.101 xref: KEGG:R03390 xref: MetaCyc:2.3.1.101-RXN xref: RHEA:18061 xref: UM-BBD_reactionID:r0346 is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0030271 name: obsolete chymase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage: Phe-Xaa > Tyr-Xaa > Trp-Xaa > Leu-Xaa." [EC:3.4.21.39] comment: This term was made obsolete because it represents a gene product. synonym: "chymase activity" EXACT [] synonym: "mast cell protease I activity" NARROW [EC:3.4.21.39] synonym: "mast cell serine proteinase" NARROW [EC:3.4.21.39] synonym: "SK protease activity" EXACT [EC:3.4.21.39] synonym: "skeletal muscle (SK) protease activity" NARROW [EC:3.4.21.39] synonym: "skeletal muscle protease" NARROW [EC:3.4.21.39] synonym: "skin chymotryptic proteinase" NARROW [EC:3.4.21.39] xref: EC:3.4.21.39 xref: MetaCyc:3.4.21.39-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030272 name: 5-formyltetrahydrofolate cyclo-ligase activity namespace: molecular_function alt_id: GO:0019006 def: "Catalysis of the reaction: 5-formyltetrahydrofolate + ATP = 5,10-methenyltetrahydrofolate + ADP + H(+) + phosphate." [EC:6.3.3.2, RHEA:10488] synonym: "5,10-methenyltetrahydrofolate synthetase activity" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.2] synonym: "5-formyltetrahydrofolate cyclodehydrase" BROAD [EC:6.3.3.2] synonym: "5-Formyltetrahydrofolate cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "formyltetrahydrofolic cyclodehydrase activity" EXACT [EC:6.3.3.2] synonym: "methenyl-THF synthetase activity" EXACT [EC:6.3.3.2] xref: EC:6.3.3.2 xref: KEGG:R02301 xref: MetaCyc:5-FORMYL-THF-CYCLO-LIGASE-RXN xref: reactome:R-HSA-6801342 "MTHFS transforms 5-formyl-THFPG to 5,10-methenyl-THFPG" xref: RHEA:10488 is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0030273 name: melanin-concentrating hormone receptor activity namespace: molecular_function def: "Combining with the cyclic peptide hormone melanin-concentrating hormone to initiate a change in cell activity." [GOC:mah] synonym: "MCH receptor" EXACT [] is_a: GO:0004930 ! G protein-coupled receptor activity is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0030274 name: LIM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LIM domain (for Lin-11 Isl-1 Mec-3) of a protein, a domain with seven conserved cysteine residues and a histidine, that binds two zinc ions and acts as an interface for protein-protein interactions." [GOC:go_curators, Pfam:PF00412] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030275 name: LRR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a LRR domain (leucine rich repeats) of a protein." [GOC:go_curators, Pfam:PF00560] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030276 name: clathrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy or light chain, the main components of the coat of coated vesicles and coated pits, and which also occurs in synaptic vesicles." [GOC:jl, GOC:mah, ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0030277 name: maintenance of gastrointestinal epithelium namespace: biological_process def: "Protection of epithelial surfaces of the gastrointestinal tract from proteolytic and caustic digestive agents." [GOC:mah] is_a: GO:0010669 ! epithelial structure maintenance is_a: GO:0022600 ! digestive system process [Term] id: GO:0030278 name: regulation of ossification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "regulation of bone biosynthesis" EXACT [] synonym: "regulation of bone formation" EXACT [] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0001503 ! ossification [Term] id: GO:0030279 name: negative regulation of ossification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ossification, the formation of bone or of a bony substance or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:go_curators] synonym: "down regulation of ossification" EXACT [] synonym: "down-regulation of ossification" EXACT [] synonym: "downregulation of ossification" EXACT [] synonym: "inhibition of ossification" NARROW [] synonym: "negative regulation of bone biosynthesis" EXACT [] synonym: "negative regulation of bone formation" EXACT [] is_a: GO:0030278 ! regulation of ossification is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0001503 ! ossification [Term] id: GO:0030280 name: structural constituent of epidermis namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of an epidermal cutaneous structure." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030281 name: structural constituent of cutaneous appendage namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of cutaneous epidermal structures such as hairs, scales, or feathers." [GOC:mah, ISBN:0878932437] is_a: GO:0030280 ! structural constituent of epidermis [Term] id: GO:0030282 name: bone mineralization namespace: biological_process def: "The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue." [GOC:mah, PMID:22936354] synonym: "bone calcification" NARROW [] is_a: GO:0031214 ! biomineral tissue development relationship: part_of GO:0001503 ! ossification [Term] id: GO:0030283 name: testosterone dehydrogenase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + NAD(P)+ = androst-4-ene-3,17-dione + NAD(P)H + H+." [EC:1.1.1.51] synonym: "17beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.51] synonym: "3(or 17)beta-hydroxysteroid:NAD(P)+ oxidoreductase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "3beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.51] synonym: "beta-hydroxy steroid dehydrogenase" BROAD [EC:1.1.1.51] xref: EC:1.1.1.51 xref: MetaCyc:1.1.1.51-RXN xref: reactome:R-HSA-193064 "Reduction of androstenedione to testosterone" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030284 name: estrogen receptor activity namespace: molecular_function def: "Combining with estrogen and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:signaling, PMID:17615392] comment: For estrogen receptors that function within the nucleus to modulate transcription, consider instead annotating to the child terms 'estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038052' or 'estrogen-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038053'. is_a: GO:0003707 ! steroid hormone receptor activity [Term] id: GO:0030285 name: integral component of synaptic vesicle membrane namespace: cellular_component def: "The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:go_curators] subset: goslim_synapse synonym: "integral to synaptic vesicle membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098563 ! intrinsic component of synaptic vesicle membrane [Term] id: GO:0030286 name: dynein complex namespace: cellular_component def: "Any of several large complexes that contain two or three dynein heavy chains and several light chains, and have microtubule motor activity." [ISBN:0815316194] is_a: GO:0005875 ! microtubule associated complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0030287 name: cell wall-bounded periplasmic space namespace: cellular_component def: "The region between the plasma membrane and the cell wall in organisms lacking an outer cell membrane such as yeast and Gram positive bacteria. The region is thinner than the equivalent in Gram negative bacteria." [GOC:mlg, GOC:mtg_sensu] synonym: "cell wall bounded periplasmic space" EXACT [] synonym: "cell wall-enclosed periplasmic space" EXACT [] synonym: "inner wall zone" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] synonym: "IWZ" NARROW [GOC:bf, GOC:md, Wikipedia:Periplasmic_space] is_a: GO:0042597 ! periplasmic space [Term] id: GO:0030288 name: outer membrane-bounded periplasmic space namespace: cellular_component def: "The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall." [GOC:mlg, GOC:mtg_sensu] synonym: "outer membrane bounded periplasmic space" EXACT [] synonym: "outer membrane-enclosed periplasmic space" EXACT [] xref: Wikipedia:Periplasmic_space is_a: GO:0042597 ! periplasmic space relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0030289 name: protein phosphatase 4 complex namespace: cellular_component def: "A protein serine/threonine phosphatase complex formed by the catalytic subunit of protein phosphatase 4 plus one or more regulatory subunits." [GOC:bhm, PMID:10026142] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030290 name: sphingolipid activator protein activity namespace: molecular_function def: "Any of a group of peptide cofactors of enzymes for the lysosomal degradation of sphingolipids. They stimulate various enzymes, including glucosylceramidase, galactosylceramidase, cerebroside-sulfatase, alpha-galactosidase, beta-galactosidase, and sphingomyelin phosphodiesterase." [ISBN:0198506732] synonym: "saposin" NARROW [] xref: reactome:R-HSA-1605717 "Ganglioside GM2 activator presents GM2 to hexosaminidase for cleavage" is_a: GO:0008047 ! enzyme activator activity [Term] id: GO:0030291 name: protein serine/threonine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein serine/threonine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity [Term] id: GO:0030292 name: protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein tyrosine kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity [Term] id: GO:0030293 name: transmembrane receptor protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity is_a: GO:0030547 ! receptor inhibitor activity [Term] id: GO:0030294 name: receptor signaling protein tyrosine kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase inhibitor activity" EXACT [] is_a: GO:0030292 ! protein tyrosine kinase inhibitor activity [Term] id: GO:0030295 name: protein kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] is_a: GO:0019209 ! kinase activator activity is_a: GO:0019887 ! protein kinase regulator activity [Term] id: GO:0030296 name: protein tyrosine kinase activator activity namespace: molecular_function def: "Increases the activity of a protein tyrosine kinase, an enzyme which phosphorylates a tyrosyl phenolic group on a protein." [GOC:ai, ISBN:0198506732] is_a: GO:0030295 ! protein kinase activator activity [Term] id: GO:0030297 name: transmembrane receptor protein tyrosine kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a transmembrane receptor protein tyrosine kinase." [GOC:mah] is_a: GO:0030296 ! protein tyrosine kinase activator activity is_a: GO:0030546 ! receptor activator activity [Term] id: GO:0030298 name: receptor signaling protein tyrosine kinase activator activity namespace: molecular_function def: "Binds to and increases the activity of a receptor signaling protein tyrosine kinase." [GOC:mah] synonym: "receptor signalling protein tyrosine kinase activator activity" EXACT [] is_a: GO:0030296 ! protein tyrosine kinase activator activity [Term] id: GO:0030299 name: intestinal cholesterol absorption namespace: biological_process def: "Uptake of cholesterol into the blood by absorption from the small intestine." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0098856 ! intestinal lipid absorption relationship: part_of GO:0044241 ! lipid digestion [Term] id: GO:0030300 name: regulation of intestinal cholesterol absorption namespace: biological_process def: "Any process that modulates the frequency, rate or extent of absorption of cholesterol into the blood, and the exclusion of other sterols from absorption." [GOC:mah, PMID:11099417] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:1904729 ! regulation of intestinal lipid absorption relationship: regulates GO:0030299 ! intestinal cholesterol absorption [Term] id: GO:0030301 name: cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah, ISBN:0198506732] is_a: GO:0015918 ! sterol transport [Term] id: GO:0030302 name: deoxynucleotide transport namespace: biological_process def: "The directed movement of a deoxynucleotide, a deoxyribonucleoside in ester linkage to phosphate, commonly at the 5' position of deoxyribose, into, out of or within a cell." [GOC:mah, ISBN:0198506732] is_a: GO:0006862 ! nucleotide transport is_a: GO:1901264 ! carbohydrate derivative transport [Term] id: GO:0030303 name: obsolete stromelysin 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of peptide bonds in collagen with preferential cleavage where P1', P2' and P3' are hydrophobic residues; action on collagen types III, IV and V is weak." [EC:3.4.24.17, EC:3.4.24.22] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 10 activity" EXACT [EC:3.4.24.22] synonym: "MMP-10" EXACT [] synonym: "proteoglycanase 2" RELATED [EC:3.4.24.22] synonym: "stromelysin 2 activity" EXACT [] synonym: "transin 2 activity" EXACT [EC:3.4.24.22] xref: EC:3.4.24.22 xref: MetaCyc:3.4.24.22-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030304 name: obsolete trypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase trypsin." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "trypsin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030305 name: heparanase activity namespace: molecular_function def: "Catalysis of the cleavage of heparan sulfate; can degrade both heparan sulfate and heparin glycosaminoglycan chains." [PMID:10916150] synonym: "heparinase activity" RELATED [] xref: reactome:R-HSA-1667005 "Heparanase (HPSE) cleaves heparan sulfate from its proteoglycan (lysosome)" xref: reactome:R-HSA-1678694 "Heparanase 2 (HPSE2) cleaves heparan sulfate from its proteoglycan (plasma membrane)" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030306 name: ADP-ribosylation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with ARF, ADP-ribosylation factor, a small monomeric cytosolic GTPase that, when bound to GTP, binds to the membranes of cells." [ISBN:0198506732] synonym: "ARF binding" EXACT [] is_a: GO:0031267 ! small GTPase binding [Term] id: GO:0030307 name: positive regulation of cell growth namespace: biological_process def: "Any process that activates or increases the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "activation of cell growth" NARROW [] synonym: "stimulation of cell growth" NARROW [] synonym: "up regulation of cell growth" EXACT [] synonym: "up-regulation of cell growth" EXACT [] synonym: "upregulation of cell growth" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045927 ! positive regulation of growth is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0016049 ! cell growth [Term] id: GO:0030308 name: negative regulation of cell growth namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, extent or direction of cell growth." [GOC:go_curators] synonym: "down regulation of cell growth" EXACT [] synonym: "down-regulation of cell growth" EXACT [] synonym: "downregulation of cell growth" EXACT [] synonym: "inhibition of cell growth" NARROW [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0045926 ! negative regulation of growth is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0016049 ! cell growth [Term] id: GO:0030309 name: poly-N-acetyllactosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0030310 name: poly-N-acetyllactosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine breakdown" EXACT [] synonym: "poly-N-acetyllactosamine catabolism" EXACT [] synonym: "poly-N-acetyllactosamine degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030311 name: poly-N-acetyllactosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of poly-N-acetyllactosamine, a carbohydrate composed of N-acetyllactosamine repeats (Gal-beta-1,4-GlcNAc-beta-1,3)n." [GOC:mah, PMID:9405606] synonym: "poly-N-acetyllactosamine anabolism" EXACT [] synonym: "poly-N-acetyllactosamine biosynthesis" EXACT [] synonym: "poly-N-acetyllactosamine formation" EXACT [] synonym: "poly-N-acetyllactosamine synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030309 ! poly-N-acetyllactosamine metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0030312 name: external encapsulating structure namespace: cellular_component def: "A structure that lies outside the plasma membrane and surrounds the entire cell or cells. This does not include the periplasmic space." [GOC:go_curators] comment: The outer membrane (of gram negative bacteria) or cell wall (of yeast or Gram positive bacteria) are defined as parts of this structure, see 'external encapsulating structure part'. subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant is_a: GO:0044464 ! cell part relationship: part_of GO:0071944 ! cell periphery [Term] id: GO:0030313 name: cell envelope namespace: cellular_component def: "An envelope that surrounds a bacterial cell and includes the cytoplasmic membrane and everything external, encompassing the periplasmic space, cell wall, and outer membrane if present." [GOC:ds, GOC:mlg, http://pathmicro.med.sc.edu/fox/cell_envelope.htm] subset: goslim_pir xref: Wikipedia:Cell_envelope is_a: GO:0031975 ! envelope [Term] id: GO:0030314 name: junctional membrane complex namespace: cellular_component def: "Complex formed in muscle cells between the membrane of the sarcoplasmic reticulum and invaginations of the plasma membrane (T-tubules)." [PMID:11535622] synonym: "triad junction" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0016528 ! sarcoplasm [Term] id: GO:0030315 name: T-tubule namespace: cellular_component def: "Invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril. The ends of T-tubules make contact with the sarcoplasmic reticulum membrane." [GOC:mtg_muscle, ISBN:0815316194] synonym: "transverse tubule" EXACT [] synonym: "triad" RELATED [] xref: Wikipedia:T-tubule is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0042383 ! sarcolemma [Term] id: GO:0030316 name: osteoclast differentiation namespace: biological_process def: "The process in which a relatively unspecialized monocyte acquires the specialized features of an osteoclast. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue." [CL:0000092, GOC:add, ISBN:0781735149, PMID:12161749] synonym: "osteoclast cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030317 name: flagellated sperm motility namespace: biological_process def: "Any process involved in the controlled movement of a flagellated sperm cell." [GOC:cilia, GOC:jl, GOC:krc] synonym: "flagellated sperm movement" EXACT [] synonym: "sperm motility" BROAD [] synonym: "sperm movement" BROAD [] xref: Wikipedia:Sperm_motility is_a: GO:0097722 ! sperm motility [Term] id: GO:0030318 name: melanocyte differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a melanocyte." [GOC:mah] synonym: "melanocyte cell differentiation" EXACT [] synonym: "melanophore differentiation" EXACT [] is_a: GO:0050931 ! pigment cell differentiation [Term] id: GO:0030319 name: obsolete cellular di-, tri-valent inorganic anion homeostasis namespace: biological_process def: "OBSOLETE. Any process involved in the maintenance of an internal steady state of divalent or trivalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] comment: This term was made obsolete because it has been split. synonym: "cellular di-, tri-valent inorganic anion homeostasis" EXACT [] is_obsolete: true consider: GO:0072501 consider: GO:0072502 [Term] id: GO:0030320 name: cellular monovalent inorganic anion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of monovalent inorganic anions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0030002 ! cellular anion homeostasis is_a: GO:0055083 ! monovalent inorganic anion homeostasis [Term] id: GO:0030321 name: transepithelial chloride transport namespace: biological_process def: "The directed movement of chloride ions from one side of an epithelium to the other." [GOC:mah] is_a: GO:0006821 ! chloride transport is_a: GO:0070633 ! transepithelial transport [Term] id: GO:0030322 name: stabilization of membrane potential namespace: biological_process def: "The accomplishment of a non-fluctuating membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane." [GOC:jl, ISBN:0198506732] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0030323 name: respiratory tube development namespace: biological_process def: "The process whose specific outcome is the progression of the respiratory tube over time, from its formation to the mature structure. The respiratory tube is assumed to mean any tube in the respiratory tract." [GOC:jid] is_a: GO:0035295 ! tube development is_a: GO:0048513 ! animal organ development [Term] id: GO:0030324 name: lung development namespace: biological_process def: "The process whose specific outcome is the progression of the lung over time, from its formation to the mature structure. In all air-breathing vertebrates the lungs are developed from the ventral wall of the oesophagus as a pouch which divides into two sacs. In amphibians and many reptiles the lungs retain very nearly this primitive sac-like character, but in the higher forms the connection with the esophagus becomes elongated into the windpipe and the inner walls of the sacs become more and more divided, until, in the mammals, the air spaces become minutely divided into tubes ending in small air cells, in the walls of which the blood circulates in a fine network of capillaries. In mammals the lungs are more or less divided into lobes, and each lung occupies a separate cavity in the thorax." [GOC:jid, UBERON:0002048] is_a: GO:0048513 ! animal organ development relationship: part_of GO:0030323 ! respiratory tube development relationship: part_of GO:0060541 ! respiratory system development [Term] id: GO:0030325 name: adrenal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the adrenal gland over time, from its formation to the mature structure. This gland can either be a discrete structure located bilaterally above each kidney, or a cluster of cells in the head kidney that perform the functions of the adrenal gland. In either case, this organ consists of two cells types, aminergic chromaffin cells and steroidogenic cortical cells." [GOC:dgh] synonym: "interrenal gland" RELATED [] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030326 name: embryonic limb morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the limb are generated and organized. A limb is an appendage of an animal used for locomotion or grasping." [GOC:bf, GOC:jl, ISBN:0395825172] is_a: GO:0035108 ! limb morphogenesis is_a: GO:0035113 ! embryonic appendage morphogenesis [Term] id: GO:0030327 name: prenylated protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylated proteins." [GOC:mah] synonym: "prenylated protein breakdown" EXACT [] synonym: "prenylated protein catabolism" EXACT [] synonym: "prenylated protein degradation" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0030328 name: prenylcysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai] synonym: "prenylcysteine breakdown" EXACT [] synonym: "prenylcysteine catabolism" EXACT [] synonym: "prenylcysteine degradation" EXACT [] is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0030329 ! prenylcysteine metabolic process is_a: GO:0042219 ! cellular modified amino acid catabolic process [Term] id: GO:0030329 name: prenylcysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prenylcysteine, 3-methyl-2-buten-1-yl-cysteine, a derivative of the amino acid cysteine formed by the covalent addition of a prenyl residue." [GOC:ai, PMID:16627894] synonym: "prenylcysteine metabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process [Term] id: GO:0030330 name: DNA damage response, signal transduction by p53 class mediator namespace: biological_process alt_id: GO:0006976 def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage." [GOC:go_curators] synonym: "DNA damage response, activation of p53" RELATED [] synonym: "p53 signaling pathway" RELATED [GOC:mah, GOC:vk] synonym: "p53-mediated DNA damage response" BROAD [] synonym: "TP53 signaling pathway" RELATED [GOC:mah, GOC:vk] is_a: GO:0042770 ! signal transduction in response to DNA damage is_a: GO:0072331 ! signal transduction by p53 class mediator [Term] id: GO:0030331 name: estrogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an estrogen receptor." [GOC:ai] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0030332 name: cyclin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cyclins, proteins whose levels in a cell varies markedly during the cell cycle, rising steadily until mitosis, then falling abruptly to zero. As cyclins reach a threshold level, they are thought to drive cells into G2 phase and thus to mitosis." [GOC:ai] is_a: GO:0005515 ! protein binding [Term] id: GO:0030334 name: regulation of cell migration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell migration." [GOC:go_curators] is_a: GO:2000145 ! regulation of cell motility relationship: regulates GO:0016477 ! cell migration [Term] id: GO:0030335 name: positive regulation of cell migration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "activation of cell migration" NARROW [] synonym: "stimulation of cell migration" NARROW [] synonym: "up regulation of cell migration" EXACT [] synonym: "up-regulation of cell migration" EXACT [] synonym: "upregulation of cell migration" EXACT [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000147 ! positive regulation of cell motility relationship: positively_regulates GO:0016477 ! cell migration [Term] id: GO:0030336 name: negative regulation of cell migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell migration." [GOC:go_curators] synonym: "down regulation of cell migration" EXACT [] synonym: "down-regulation of cell migration" EXACT [] synonym: "downregulation of cell migration" EXACT [] synonym: "inhibition of cell migration" NARROW [] is_a: GO:0030334 ! regulation of cell migration is_a: GO:2000146 ! negative regulation of cell motility relationship: negatively_regulates GO:0016477 ! cell migration [Term] id: GO:0030337 name: DNA polymerase processivity factor activity namespace: molecular_function def: "An enzyme regulator activity that increases the processivity of polymerization by DNA polymerase, by allowing the polymerase to move rapidly along DNA while remaining topologically bound to it." [GOC:mah, PMID:7903401, PMID:8087839] synonym: "processivity clamp" EXACT [] synonym: "sliding clamp" NARROW [GOC:jh2, PMID:23012374] is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0030338 name: CMP-N-acetylneuraminate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + NADPH + H+ + O2 = CMP-N-glycoloylneuraminate + NADP+ + H2O." [EC:1.14.18.2] comment: Note that this was EC:1.14.13.45. synonym: "CMP-N-acetylneuraminate hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminate,ferrocytochrome-b5:oxygen oxidoreductase (N-acetyl-hydroxylating)" EXACT [EC:1.14.18.2] synonym: "CMP-N-acetylneuraminic acid hydroxylase activity" EXACT [] synonym: "CMP-Neu5Ac hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "cytidine monophosphoacetylneuraminate monooxygenase activity" EXACT [EC:1.14.18.2] synonym: "cytidine-5'-monophosphate-N-acetylneuraminic acid hydroxylase activity" EXACT [EC:1.14.18.2] synonym: "N-acetylneuraminic monooxygenase activity" EXACT [EC:1.14.18.2] xref: EC:1.14.18.2 xref: MetaCyc:1.14.13.45-RXN is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0030339 name: fatty-acyl-ethyl-ester synthase activity namespace: molecular_function def: "Catalysis of the reaction: a long-chain-acyl ethyl ester + H2O = a long-chain carboxylic acid + ethanol." [EC:3.1.1.67] synonym: "FAEE synthase activity" EXACT [EC:3.1.1.67] synonym: "FAEES activity" EXACT [EC:3.1.1.67] synonym: "fatty-acyl ethyl ester synthase" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-ethyl-ester acylhydrolase activity" EXACT [EC:3.1.1.67] xref: EC:3.1.1.67 xref: MetaCyc:FATTY-ACYL-ETHYL-ESTER-SYNTHASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030340 name: hyaluronate lyase activity namespace: molecular_function def: "Catalysis of the reaction: hyaluronate = n 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine." [EC:4.2.2.1] synonym: "glucuronoglycosaminoglycan lyase activity" EXACT [EC:4.2.2.1] synonym: "hyaluronidase [but cf. EC 3.2.1.35 (hyalurononglucosaminidase) and EC 3.2.1.36 (hyaluronoglucuronidase)]" RELATED [EC:4.2.2.1] synonym: "hyaluronidase activity" BROAD [EC:4.2.2.1] synonym: "mucinase activity" EXACT [EC:4.2.2.1] synonym: "spreading factor activity" RELATED [EC:4.2.2.1] xref: EC:4.2.2.1 xref: MetaCyc:HYALURONATE-LYASE-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030341 name: chondroitin AC lyase activity namespace: molecular_function def: "Catalysis of the eliminative degradation of polysaccharides containing 1,4-beta-D-hexosaminyl and 1,3-beta-D-glucuronosyl linkages to disaccharides containing 4-deoxy-beta-D-gluc-4-enuronosyl groups." [EC:4.2.2.5] synonym: "ChnAC" RELATED [] synonym: "chondroitin AC eliminase activity" EXACT [EC:4.2.2.5] synonym: "chondroitin lyase activity" EXACT [] synonym: "chondroitin sulfate lyase activity" EXACT [EC:4.2.2.5] synonym: "chondroitinase AC" RELATED [] synonym: "chondroitinase activity" BROAD [] xref: EC:4.2.2.5 xref: MetaCyc:4.2.2.5-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030342 name: 1-alpha,25-dihydroxyvitamin D3 24-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of C-24 of 1-alpha,25-hydroxycholecalciferol (25-hydroxyvitamin D3; calcitriol)." [PMID:8506296] synonym: "1,25-(OH)2D3 24-hydroxylase activity" EXACT [PMID:8506296] synonym: "calcitriol 24-hydroxylase activity" EXACT [CHEBI:17823, GOC:mah] xref: reactome:R-HSA-209765 "CYP24A1 hydroxylates 1,25(OH)2D, inactivating it" xref: reactome:R-HSA-211950 "CYP24A1 24-hydroxylates CTL" is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0030343 name: vitamin D3 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: vitamin D3 + NADPH + H+ + O2 = calcidiol + NADP+ + H2O." [ISBN:0471331309, MetaCyc:RXN-9829] synonym: "cholecalciferol 25-hydroxylase activity" EXACT [] xref: MetaCyc:RXN-9829 xref: reactome:R-HSA-209845 "CYP2R1 25-hydroxylates VD3 to 25(OH)D" is_a: GO:0070643 ! vitamin D 25-hydroxylase activity [Term] id: GO:0030345 name: structural constituent of tooth enamel namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of tooth enamel." [GOC:mah] is_a: GO:0030021 ! extracellular matrix structural constituent conferring compression resistance [Term] id: GO:0030346 name: protein phosphatase 2B binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 2B." [GOC:jl] synonym: "calcineurin binding" EXACT [] synonym: "protein phosphatase 3 binding" RELATED [GOC:dph, GOC:rl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0030348 name: syntaxin-3 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the SNAP receptor syntaxin-3." [GOC:ai] is_a: GO:0019905 ! syntaxin binding [Term] id: GO:0030350 name: iron-responsive element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iron-responsive element, a regulatory sequence found in the 5'- and 3'-untranslated regions of mRNAs encoding many iron-binding proteins." [PMID:3198610, PMID:8710843] synonym: "IRE binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0030351 name: inositol-1,3,4,5,6-pentakisphosphate 3-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,3,4,5,6-pentakisphosphate + H2O = inositol-1,4,5,6-tetrakisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 xref: reactome:R-HSA-1855163 "I(1,3,4,5,6)P5 is dephosphorylated to I(1,4,5,6)P4 by MINPP1 in the ER lumen" is_a: GO:0052827 ! inositol pentakisphosphate phosphatase activity [Term] id: GO:0030352 name: inositol-1,4,5,6-tetrakisphosphate 6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: inositol-1,4,5,6-tetrakisphosphate + H2O = inositol-1,4,5-trisphosphate + phosphate." [GOC:ai] xref: EC:3.1.3 is_a: GO:0052743 ! inositol tetrakisphosphate phosphatase activity [Term] id: GO:0030353 name: fibroblast growth factor receptor antagonist activity namespace: molecular_function def: "Interacts with the fibroblast growth factor receptor to reduce the action of another ligand, the agonist." [GOC:mah] synonym: "FGF receptor antagonist activity" EXACT [] synonym: "FGFR antagonist activity" EXACT [] is_a: GO:0005104 ! fibroblast growth factor receptor binding is_a: GO:0048019 ! receptor antagonist activity [Term] id: GO:0030354 name: melanin-concentrating hormone activity namespace: molecular_function def: "The action characteristic of melanin-concentrating hormone, a cyclic peptide hormone that, upon receptor binding, induces melanin aggregation in melanocytes, and is also involved in regulating food intake and energy balance in mammals." [GOC:mah, PMID:11416225, PMID:9792536] is_a: GO:0005179 ! hormone activity [Term] id: GO:0030355 name: obsolete small nucleolar ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_obsolete: true replaced_by: GO:0005732 [Term] id: GO:0030356 name: obsolete small cytoplasmic ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0030363 name: obsolete pre-mRNA cleavage factor activity namespace: molecular_function def: "OBSOLETE. Any activity required for the process of mRNA cleavage." [GOC:mah, PMID:10357856] comment: This term was made obsolete because it describes a biological process. synonym: "pre-mRNA cleavage factor activity" EXACT [] is_obsolete: true consider: GO:0006379 [Term] id: GO:0030364 name: obsolete cleavage and polyadenylylation specificity factor activity namespace: molecular_function def: "OBSOLETE. A factor required in mRNA 3' end processing for both the cleavage and poly(A) addition reactions and, consistent with this function, recognizes AAUAAA, a signal also essential for both reactions." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "cleavage and polyadenylation specificity factor activity" EXACT [] synonym: "cleavage and polyadenylylation specificity factor activity" EXACT [] synonym: "cleavage/polyadenylation specificity factor activity" EXACT [] synonym: "CPSF" EXACT [] is_obsolete: true replaced_by: GO:0005847 consider: GO:0006378 consider: GO:0006379 [Term] id: GO:0030365 name: obsolete cleavage stimulation factor activity namespace: molecular_function def: "OBSOLETE. A factor is necessary for cleavage but not for poly(A) addition in mRNA 3' end processing; can stimulate poly(A) addition on substrates with a CstF binding site upstream of the AAUAAA hexanucleotide." [PMID:10357856] comment: This term was made obsolete because it describes a cellular component. synonym: "cleavage stimulation factor activity" EXACT [] synonym: "CstF" EXACT [] is_obsolete: true replaced_by: GO:0005848 consider: GO:0006379 [Term] id: GO:0030366 name: molybdopterin synthase activity namespace: molecular_function def: "Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis." [PMID:18154309, PMID:8514783] xref: EC:2.8.1.12 xref: reactome:R-HSA-947541 "Sulfhydrylation and ring cleavage of precursor Z" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0030367 name: interleukin-17 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17 receptor." [GOC:ai] synonym: "IL-17" NARROW [] synonym: "interleukin-17 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030368 name: interleukin-17 receptor activity namespace: molecular_function def: "Combining with any member of the interleukin-17 family of cytokines and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:jl, GOC:signaling] synonym: "IL-17 receptor activity" EXACT [GOC:mah] synonym: "IL-17R" EXACT [] xref: Wikipedia:Interleukin-17_receptor is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0030369 name: ICAM-3 receptor activity namespace: molecular_function def: "Combining with ICAM-3, intercellular adhesion molecule 3, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. ICAM-3, or CD50, are constitutively expressed on monocytes, granulocytes and lymphocytes; on physiological stimulation, they become transiently phosphorylated on serine residues." [GOC:ai, GOC:signaling, ISBN:0198506732, PMID:7515813] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0030370 name: intercellular adhesion molecule-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with receptors for intercellular adhesion molecule-3 (ICAM-3), such as DC-SIGN and LFA-1." [GOC:ceb, PMID:11473836] synonym: "ICAM-3 receptor binding" EXACT [] synonym: "ICAM-3 receptor ligand" NARROW [] synonym: "intercellular adhesion molecule-3 receptor ligand" NARROW [] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030371 name: translation repressor activity namespace: molecular_function def: "Antagonizes ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai, GOC:clt] is_a: GO:0045182 ! translation regulator activity [Term] id: GO:0030372 name: high molecular weight B cell growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the high molecular weight B cell growth factor receptor." [GOC:ai] synonym: "high molecular weight B cell growth factor receptor ligand" NARROW [] synonym: "high molecular weight B lymphocyte growth factor receptor binding" EXACT [] synonym: "high molecular weight B-cell growth factor receptor binding" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0030373 name: high molecular weight B cell growth factor receptor activity namespace: molecular_function def: "Combining with a high molecular weight B cell growth factor and transmitting the signal to initiate a change in cell activity." [GOC:ai, GOC:signaling, PMID:2681271] synonym: "high molecular weight B lymphocyte growth factor receptor activity" EXACT [] synonym: "high molecular weight B-cell growth factor receptor activity" EXACT [] synonym: "high molecular weight B-lymphocyte growth factor receptor activity" EXACT [] synonym: "HMW-BCGF receptor" EXACT [PMID:2681271] is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0030374 name: nuclear receptor transcription coactivator activity namespace: molecular_function alt_id: GO:0038049 def: "The function of a transcription cofactor that activates transcription in conjuction with a ligand-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] comment: GO:0030374 is intended for annotation of nuclear receptors that regulate transcription by binding to transcription factors or transcription factor complexes. When the nuclear receptor functions by binding directly to DNA response elements, consider instead annotating to 'nuclear receptor activity ; GO:0004879'. synonym: "ligand-activated RNA polymerase II transcription factor binding transcription factor activity" EXACT [] synonym: "ligand-dependent nuclear receptor transcription co-activator activity" EXACT [] synonym: "ligand-dependent nuclear receptor transcription coactivator activity" EXACT [] synonym: "transcription factor activity, ligand-activated RNA polymerase II transcription factor binding" EXACT [] is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0030375 name: thyroid hormone receptor coactivator activity namespace: molecular_function alt_id: GO:0010861 def: "The function of a transcription cofactor that activates transcription in conjunction with a thyroid hormone-dependent nuclear receptor from a RNA polymerase II promoter; does not bind DNA itself." [GOC:dph, GOC:tb] synonym: "thyroid hormone receptor activator activity" NARROW [] synonym: "thyroid hormone receptor co-activator activity" EXACT [] is_a: GO:0030374 ! nuclear receptor transcription coactivator activity [Term] id: GO:0030377 name: urokinase plasminogen activator receptor activity namespace: molecular_function def: "Combining with the urokinase plasminogen activator to initiate a change in cell activity." [GOC:mah, PMID:16456079] synonym: "U-plasminogen activator receptor activity" EXACT [GOC:bf] synonym: "uPAR" EXACT [] synonym: "urokinase plasminogen activator receptor" EXACT [] xref: Wikipedia:Urokinase_receptor is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0030378 name: serine racemase activity namespace: molecular_function def: "Catalysis of the synthesis of free D-serine from L-serine." [GOC:kd] xref: EC:5.1.1.18 xref: MetaCyc:5.1.1.18-RXN xref: reactome:R-HSA-9014766 "SRR dimer:PXLP isomerises L-Ser to D-Ser" is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0030379 name: neurotensin receptor activity, non-G protein-coupled namespace: molecular_function def: "Combining with neurotensin, a neuropeptide active in the central and peripheral nervous system in mammals, and transmitting the signal from one side of the membrane to the other by a mechanism independent of coupling to G proteins." [GOC:mah, GOC:signaling, PMID:9756851] synonym: "neurotensin receptor activity, non G protein coupled" EXACT [] synonym: "neurotensin receptor activity, non-G-protein coupled" EXACT [] synonym: "non G protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein coupled neurotensin receptor activity" EXACT [] synonym: "non-G-protein-coupled neurotensin receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0030380 name: interleukin-17E receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-17E receptor." [GOC:ai] synonym: "IL-17E" NARROW [] synonym: "interleukin-17E receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0030381 name: chorion-containing eggshell pattern formation namespace: biological_process def: "The regionalization process that gives rise to the structural pattern of a chorion-containing eggshell such as those found in insects." [GOC:bf, GOC:mtg_sensu] is_a: GO:0003002 ! regionalization is_a: GO:0003006 ! developmental process involved in reproduction relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0030382 name: sperm mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of sperm mitochondria; the process in which they take on their characteristic morphology; they are flattened, elongated, and arranged circumferentially into a tight helical coil around the tail-dense fibers of the mature sperm." [GOC:dph, GOC:jl, GOC:mah, PMID:8833144] synonym: "sperm mitochondria organisation" EXACT [GOC:curators] synonym: "sperm mitochondria organization and biogenesis" RELATED [GOC:mah] synonym: "sperm mitochondrion organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0030383 name: obsolete host-pathogen interaction namespace: biological_process def: "OBSOLETE. Any interaction between a pathogen and its host organism." [GOC:jl] comment: This term was made obsolete because more appropriate terms were created. synonym: "host-pathogen interaction" EXACT [] is_obsolete: true consider: GO:0044403 [Term] id: GO:0030385 name: ferredoxin:thioredoxin reductase activity namespace: molecular_function def: "Catalysis of the two-electron reduction of the disulfide of thioredoxins with electrons from ferredoxin involving a 4Fe-4S cluster and an adjacent active-site disulfide." [PMID:14769790] is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0030386 name: ferredoxin:thioredoxin reductase complex namespace: cellular_component def: "A protein complex that possesses ferredoxin:thioredoxin reductase activity." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'ferredoxin:thioredoxin reductase activity ; GO:0030385'. is_a: GO:0044434 ! chloroplast part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0030387 name: fructosamine-3-kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of fructosamine to form fructosamine-3-kinase." [PMID:11016445] is_a: GO:0016301 ! kinase activity [Term] id: GO:0030388 name: fructose 1,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 1,6-bisphosphate, also known as FBP. The D enantiomer is a metabolic intermediate in glycolysis and gluconeogenesis." [ISBN:0198506732] synonym: "fructose 1,6-bisphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate-containing compound metabolic process is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0030389 name: fructosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0030391 name: fructosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine anabolism" EXACT [] synonym: "fructosamine biosynthesis" EXACT [] synonym: "fructosamine formation" EXACT [] synonym: "fructosamine synthesis" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0030392 name: fructosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructosamine, a fructose molecule containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] synonym: "fructosamine breakdown" EXACT [] synonym: "fructosamine catabolism" EXACT [] synonym: "fructosamine degradation" EXACT [] is_a: GO:0030389 ! fructosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0030393 name: fructoselysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoselysine, a fructose molecule containing a lysine group in place of a hydroxyl group." [GOC:ai] synonym: "fructoselysine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030394 name: fructoseglycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructoseglycine, a fructose molecule containing a glycine group in place of a hydroxyl group." [GOC:ai] synonym: "fructoseglycine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006575 ! cellular modified amino acid metabolic process is_a: GO:0030389 ! fructosamine metabolic process [Term] id: GO:0030395 name: lactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with lactose, a disaccharide of glucose and galactose, the carbohydrate of milk." [GOC:jl, ISBN:01928006X] is_a: GO:0048030 ! disaccharide binding [Term] id: GO:0030397 name: membrane disassembly namespace: biological_process def: "The controlled breakdown of any cell membrane in the context of a normal process such as autophagy." [GOC:mah] synonym: "membrane breakdown" EXACT [] synonym: "membrane catabolism" EXACT [] synonym: "membrane degradation" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0061024 ! membrane organization [Term] id: GO:0030398 name: peroxisomal membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of cargo-carrying vesicles formed during peroxisome degradation." [GOC:mah, PMID:11382760] synonym: "peroxisomal membrane breakdown" EXACT [] synonym: "peroxisomal membrane catabolism" EXACT [] synonym: "peroxisomal membrane degradation" EXACT [] is_a: GO:0030397 ! membrane disassembly is_a: GO:1903008 ! organelle disassembly relationship: part_of GO:0030242 ! autophagy of peroxisome [Term] id: GO:0030399 name: autophagosome membrane disassembly namespace: biological_process def: "The controlled breakdown of the membranes of autophagosomes." [GOC:autophagy, GOC:mah] synonym: "autophagic membrane breakdown" EXACT [] synonym: "autophagic membrane catabolism" NARROW [GOC:autophagy] synonym: "autophagic membrane degradation" NARROW [GOC:autophagy] synonym: "autophagic vacuole membrane disassembly" EXACT [GOC:autophagy] is_a: GO:0030397 ! membrane disassembly is_a: GO:1905037 ! autophagosome organization [Term] id: GO:0030400 name: obsolete protease substrate recruitment factor activity namespace: molecular_function def: "OBSOLETE. A recruiting factor or adaptor molecule associated with the proteasome that activates degradation of specific proteasomal substrates and links them to the degradation machinery; it is not involved in ubiquitination; does not possess proteolytic activity." [PMID:11500370] comment: This term was made obsolete because it represents a gene product. synonym: "protease substrate recruitment factor activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0030401 name: obsolete transcription antiterminator activity namespace: molecular_function def: "OBSOLETE. Functions to prevent the termination of RNA synthesis. Acts as a regulatory device, e.g. in phage lambda, enabling a terminator to be masked from RNA polymerase so that distal genes can be expressed." [ISBN:0198506732] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription antiterminator activity" EXACT [] synonym: "transcriptional antiterminator activity" EXACT [] is_obsolete: true consider: GO:0001072 consider: GO:0001073 consider: GO:0006353 [Term] id: GO:0030402 name: obsolete matrilysin-2 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrilysin-2 activity" EXACT [] synonym: "matrix metalloproteinase 26" EXACT [] synonym: "MMP-26" EXACT [] xref: EC:3.4.24 is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030403 name: obsolete collagenase 4 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase 4 activity" EXACT [] synonym: "matrix metalloproteinase 18" EXACT [] synonym: "MMP-18" NARROW [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030404 name: obsolete collagenase 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "collagenase 3 activity" EXACT [] synonym: "matrix metalloproteinase 13" EXACT [] synonym: "MMP-13" EXACT [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0030405 name: obsolete matrix metalloproteinase 19 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 19 activity" EXACT [] synonym: "MMP-19" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030406 name: obsolete matrix metalloproteinase 25 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 25 activity" EXACT [] synonym: "MMP-25" EXACT [] synonym: "MT6-MMP" EXACT [] is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0030407 name: formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a formimino group from 5-formimidoyltetrahydrofolate to an acceptor molecule such as an amino acid." [EC:2.1.2.4, EC:2.1.2.5, GOC:mah] synonym: "formiminotransferase activity" EXACT [] is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0030408 name: glycine formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + glycine = (6S)-5,6,7,8-tetrahydrofolate + N-formimidoylglycine." [EC:2.1.2.4, RHEA:24288] synonym: "5-formimidoyltetrahydrofolate:glycine N-formimidoyltransferase activity" EXACT [EC:2.1.2.4] synonym: "FIG formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "formiminoglycine formiminotransferase activity" EXACT [EC:2.1.2.4] synonym: "glycine formiminotransferase activity" EXACT [] xref: EC:2.1.2.4 xref: KEGG:R02729 xref: MetaCyc:GLYCINE-FORMIMINOTRANSFERASE-RXN xref: RHEA:24288 is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030409 name: glutamate formimidoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + L-glutamate = tetrahydrofolate + N-formimidoyl-L-glutamate." [EC:2.1.2.5] synonym: "5-formimidoyltetrahydrofolate:L-glutamate N-formimidoyltransferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic acid transferase activity" EXACT [EC:2.1.2.5] synonym: "formiminoglutamic formiminotransferase activity" EXACT [EC:2.1.2.5] synonym: "glutamate formiminotransferase activity" EXACT [] synonym: "glutamate formyltransferase activity" EXACT [EC:2.1.2.5] xref: EC:2.1.2.5 xref: MetaCyc:GLUTAMATE-FORMIMINOTRANSFERASE-RXN is_a: GO:0030407 ! formimidoyltransferase activity [Term] id: GO:0030410 name: nicotianamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3 S-adenosyl-L-methionine(1+) = 3 S-methyl-5'-thioadenosine + 3 H(+) + nicotianamine." [EC:2.5.1.43, RHEA:16481] synonym: "S-adenosyl-L-methionine:S-adenosyl-L-methionine:S-adenosyl-L-methionine 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.43] xref: EC:2.5.1.43 xref: KEGG:R00075 xref: MetaCyc:2.5.1.43-RXN xref: RHEA:16481 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0030411 name: scytalone dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: scytalone = 1,3,8-trihydroxynaphthalene + H(2)O." [EC:4.2.1.94, RHEA:24396] synonym: "scytalone 7,8-hydro-lyase (1,3,8-trihydroxynaphthalene-forming)" EXACT [EC:4.2.1.94] synonym: "scytalone 7,8-hydro-lyase activity" EXACT [EC:4.2.1.94] xref: EC:4.2.1.94 xref: KEGG:R02907 xref: MetaCyc:SCYTALONE-DEHYDRATASE-RXN xref: RHEA:24396 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0030412 name: formimidoyltetrahydrofolate cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: 5-formimidoyltetrahydrofolate + 2 H(+) = 5,10-methenyltetrahydrofolate + NH(4)(+)." [EC:4.3.1.4, RHEA:22736] comment: Note that cyclodeaminases are lyases according to EC, whereas deaminases are hydrolases. synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.4] synonym: "5-formimidoyltetrahydrofolate ammonia-lyase (cyclizing; 5,10-methenyltetrahydrofolate-forming)" EXACT [EC:4.3.1.4] synonym: "formiminotetrahydrofolate cyclodeaminase activity" EXACT [EC:4.3.1.4] xref: EC:4.3.1.4 xref: KEGG:R02302 xref: MetaCyc:4.3.1.4-RXN xref: reactome:R-HSA-70920 "N-formiminoglutamate + tetrahydrofolate => glutamate + 5-formiminotetrahydrofolate" xref: RHEA:22736 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0030413 name: competence pheromone activity namespace: molecular_function def: "A small peptide excreted by a naturally transformable bacterium (e.g. Bacillus subtilis) that transmits a signal required for the establishment of competence." [GOC:mah, PMID:7698645] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0030414 name: peptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a peptidase, any enzyme that catalyzes the hydrolysis peptide bonds." [GOC:jl] synonym: "protease inhibitor activity" NARROW [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0061134 ! peptidase regulator activity [Term] id: GO:0030415 name: obsolete carboxypeptidase A inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the enzyme carboxypeptidase A." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "carboxypeptidase A inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0030414 [Term] id: GO:0030416 name: methylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylamine (CH3NH2)." [ISBN:0721662544] synonym: "methylamine metabolism" EXACT [] synonym: "methylammonium metabolic process" EXACT [] synonym: "methylammonium metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process is_a: GO:1901160 ! primary amino compound metabolic process [Term] id: GO:0030417 name: nicotianamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0072350 ! tricarboxylic acid metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0030418 name: nicotianamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine anabolism" EXACT [] synonym: "nicotianamine biosynthesis" EXACT [] synonym: "nicotianamine formation" EXACT [] synonym: "nicotianamine synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0072351 ! tricarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0030419 name: nicotianamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotianamine, 2(S),3'2(S),3''(S)-N-(N-(3-amino-3-carboxypropyl)-3-amino-3-carboxypropyl)-azetidine-2-carboxylic acid." [GOC:mah, PMID:10069850] synonym: "nicotianamine breakdown" EXACT [] synonym: "nicotianamine catabolism" EXACT [] synonym: "nicotianamine degradation" EXACT [] is_a: GO:0030417 ! nicotianamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0042737 ! drug catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0072352 ! tricarboxylic acid catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0030420 name: establishment of competence for transformation namespace: biological_process def: "The process in which a naturally transformable bacterium acquires the ability to take up exogenous DNA. This term should be applied only to naturally transformable bacteria, and should not be used in the context of artificially induced bacterial transformation." [GOC:mah, ISBN:1555811027] is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0030421 name: defecation namespace: biological_process def: "The expulsion of feces from the rectum." [GOC:mah] xref: Wikipedia:Defecation is_a: GO:0007588 ! excretion [Term] id: GO:0030422 name: production of siRNA involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form small interfering RNA molecules (siRNAs) of 21-23 nucleotides, in the context of RNA interference." [GOC:mah, PMID:11524674] synonym: "production of guide RNAs involved in RNA interference" EXACT [GOC:mah] synonym: "RNA interference, production of guide RNAs" EXACT [] synonym: "RNA interference, production of siRNA" EXACT [GOC:mah] is_a: GO:0070918 ! production of small RNA involved in gene silencing by RNA relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030423 name: targeting of mRNA for destruction involved in RNA interference namespace: biological_process def: "The process in which small interfering RNAs target cognate mRNA molecules for degradation." [PMID:11524674] synonym: "RNA interference, targeting of mRNA for destruction" EXACT [GOC:mah] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0016246 ! RNA interference [Term] id: GO:0030424 name: axon namespace: cellular_component def: "The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter." [GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1770195789 xref: Wikipedia:Axon is_a: GO:0043005 ! neuron projection [Term] id: GO:0030425 name: dendrite namespace: cellular_component def: "A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body." [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] xref: NIF_Subcellular:sao1211023249 xref: Wikipedia:Dendrite is_a: GO:0043005 ! neuron projection is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0097447 ! dendritic tree [Term] id: GO:0030426 name: growth cone namespace: cellular_component def: "The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic." [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468] xref: Wikipedia:Growth_cone is_a: GO:0030427 ! site of polarized growth is_a: GO:0033267 ! axon part relationship: part_of GO:0150034 ! distal axon [Term] id: GO:0030427 name: site of polarized growth namespace: cellular_component alt_id: GO:0000134 alt_id: GO:0030483 def: "Any part of a cell where non-isotropic growth takes place." [GOC:mah] subset: goslim_aspergillus subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part [Term] id: GO:0030428 name: cell septum namespace: cellular_component def: "A structure composed of peptidoglycan and often chitin in addition to other materials. It usually forms perpendicular to the long axis of a cell or hypha and grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells." [GOC:clt, ISBN:0471940526] subset: goslim_pir synonym: "cross wall" EXACT [] synonym: "septum" BROAD [] is_a: GO:0044464 ! cell part [Term] id: GO:0030429 name: kynureninase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + H2O = anthranilate + L-alanine." [EC:3.7.1.3] synonym: "kynurenine hydrolase activity" EXACT [EC:3.7.1.3] synonym: "L-kynurenine hydrolase activity" EXACT [EC:3.7.1.3] xref: EC:3.7.1.3 xref: MetaCyc:KYNURENINASE-RXN xref: reactome:R-HSA-71217 "3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine" xref: RHEA:16813 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030430 name: host cell cytoplasm namespace: cellular_component def: "The cytoplasm of a host cell." [GOC:mah] is_a: GO:0033646 ! host intracellular part [Term] id: GO:0030431 name: sleep namespace: biological_process def: "Any process in which an organism enters and maintains a periodic, readily reversible state of reduced awareness and metabolic activity. Usually accompanied by physical relaxation, the onset of sleep in humans and other mammals is marked by a change in the electrical activity of the brain." [ISBN:0192800981] subset: goslim_pir synonym: "diapause" RELATED [] synonym: "dormancy" RELATED [] synonym: "lethargus" RELATED [] xref: Wikipedia:Sleep is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030432 name: peristalsis namespace: biological_process def: "A wavelike sequence of involuntary muscular contraction and relaxation that passes along a tubelike structure, such as the intestine, impelling the contents onwards." [ISBN:0198506732] xref: Wikipedia:Peristalsis is_a: GO:0014821 ! phasic smooth muscle contraction [Term] id: GO:0030433 name: ubiquitin-dependent ERAD pathway namespace: biological_process def: "The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome." [GOC:mah, GOC:rb, PMID:14607247, PMID:19520858] comment: See also the biological process terms 'ERAD pathway ; GO:0036503', 'unfolded protein response ; GO:0030968' and 'retrograde protein transport, ER to cytosol ; GO:0030970'. synonym: "endoplasmic reticulum-associated ubiquitin-dependent protein catabolic process" EXACT [] synonym: "endoplasmic reticulum-associated ubiqutin-dependent protein catabolism" EXACT [] synonym: "ER-associated ubiquitin-dependent protein breakdown" EXACT [] synonym: "ER-associated ubiquitin-dependent protein catabolic process" EXACT [GOC:vw] synonym: "ER-associated ubiquitin-dependent protein catabolism" EXACT [] synonym: "ER-associated ubiquitin-dependent protein degradation" EXACT [] synonym: "ERAD" BROAD [] synonym: "ubiquitin-dependent proteasomal protein catabolism of ER proteins" EXACT [GOC:bf] is_a: GO:0036503 ! ERAD pathway is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0030435 name: sporulation resulting in formation of a cellular spore namespace: biological_process def: "The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction." [GOC:mah, GOC:pamgo_curators, ISBN:0072992913] comment: Note that the synonym 'spore differentiation', like the term name and definition, refers to differentiation into a spore rather than any subsequent developmental changes that a spore may undergo. synonym: "cellular spore formation by sporulation" EXACT [GOC:dph, GOC:tb] synonym: "spore biosynthesis" EXACT [] synonym: "spore differentiation" EXACT [] synonym: "spore formation" EXACT [] xref: Wikipedia:Sporogenesis is_a: GO:0030154 ! cell differentiation is_a: GO:0043934 ! sporulation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0030436 name: asexual sporulation namespace: biological_process def: "The formation of spores derived from the products of an asexual cell division. Examples of this process are found in bacteria and fungi." [GOC:mah, PMID:9529886] subset: goslim_aspergillus synonym: "asexual reproductive sporulation" EXACT [] synonym: "asexual spore formation" EXACT [] synonym: "mitotic spore formation" EXACT [] synonym: "mitotic sporulation" EXACT [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0043934 ! sporulation [Term] id: GO:0030437 name: ascospore formation namespace: biological_process alt_id: GO:0007151 def: "The process in which cells that are products of meiosis acquire the specialized features of ascospores. Ascospores are generally found in clusters of four or eight spores within a single mother cell, the ascus, and are characteristic of the ascomycete fungi (phylum Ascomycota)." [GOC:di, GOC:mah, GOC:mcc, PMID:16339736] comment: Note that ascospores and asci are separate biological structures. The ascus is the structure that contain the ascospores, but the development of the ascus is a different process than the formation of the ascospores themselves; for instance, some mutations affect sporulation without affecting ascus development. For this reason, GO:0030437 ascospore formation and GO:0075317 ascus development are different terms and are not linked. subset: goslim_pombe synonym: "ascospore biosynthesis" EXACT [] synonym: "spore formation" BROAD [] synonym: "sporulation" BROAD [] is_a: GO:0022413 ! reproductive process in single-celled organism is_a: GO:0043935 ! sexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0030438 name: obsolete MAPKKK cascade during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030439 name: obsolete activation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030440 name: obsolete activation of MAPKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030441 name: obsolete activation of MAPKKK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030442 name: obsolete inactivation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030443 name: obsolete nuclear translocation of MAPK during sporulation (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK during sporulation (sensu Fungi)" EXACT [] is_obsolete: true [Term] id: GO:0030444 name: obsolete microtubule depolymerization during nuclear congression namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because the entire branch of the ontology was changed. synonym: "microtubule depolymerization during nuclear congression" EXACT [] is_obsolete: true replaced_by: GO:0007019 [Term] id: GO:0030445 name: yeast-form cell wall namespace: cellular_component def: "The wall surrounding a cell of a dimorphic fungus growing in the single-cell budding yeast form, in contrast to the filamentous or hyphal form." [GOC:mah, GOC:mcc] comment: See also the Fungal Anatomy Ontology term 'vegetative cell ; FAO:0000032'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030446 name: hyphal cell wall namespace: cellular_component def: "The cell wall surrounding a fungal hypha." [GOC:mah] comment: See also the Fungal Anatomy Ontology term 'hypha ; FAO:0001001'. is_a: GO:0009277 ! fungal-type cell wall [Term] id: GO:0030447 name: filamentous growth namespace: biological_process def: "The process in which a multicellular organism, a unicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape." [GOC:mcc, PMID:11729141] subset: goslim_aspergillus subset: goslim_candida is_a: GO:0040007 ! growth [Term] id: GO:0030448 name: hyphal growth namespace: biological_process def: "Growth of fungi as threadlike, tubular structures that may contain multiple nuclei and may or may not be divided internally by septa, or cross-walls." [GOC:mcc, ISBN:0471522295] subset: goslim_candida is_a: GO:0030447 ! filamentous growth [Term] id: GO:0030449 name: regulation of complement activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade" EXACT [GOC:add] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0002920 ! regulation of humoral immune response relationship: regulates GO:0006956 ! complement activation [Term] id: GO:0030450 name: regulation of complement activation, classical pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the classical pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, classical pathway" EXACT [GOC:add] is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin is_a: GO:0030449 ! regulation of complement activation relationship: regulates GO:0006958 ! complement activation, classical pathway [Term] id: GO:0030451 name: regulation of complement activation, alternative pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the alternative pathway of complement activation." [GOC:go_curators] synonym: "regulation of complement cascade, alternative pathway" EXACT [GOC:add] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response relationship: regulates GO:0006957 ! complement activation, alternative pathway [Term] id: GO:0030455 name: obsolete MAPKKK cascade (mating sensu Fungi) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transducing mating pheromone signal in a fungus." [GOC:mah] comment: This term was made obsolete because it is a gene product specific term. synonym: "MAPKKK cascade (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030456 name: obsolete activation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030457 name: obsolete activation of MAPKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030458 name: obsolete activation of MAPKKK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "activation of MAPKKK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030459 name: obsolete inactivation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "inactivation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030460 name: obsolete nuclear translocation of MAPK (mating sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is a gene product specific term. synonym: "nuclear translocation of MAPK (mating sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0030463 name: obsolete cell aging (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. synonym: "cell aging (sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0030464 name: obsolete aging dependent sterility (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. synonym: "aging dependent sterility (sensu Fungi)" EXACT [] is_obsolete: true consider: GO:0030466 [Term] id: GO:0030465 name: obsolete autophagic death (sensu Fungi) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because a more correct term has been created. synonym: "autophagic death (sensu Fungi)" EXACT [] is_obsolete: true consider: GO:0048102 [Term] id: GO:0030466 name: chromatin silencing at silent mating-type cassette namespace: biological_process alt_id: GO:0006347 def: "Repression of transcription at silent mating-type loci by alteration of the structure of chromatin." [GOC:mcc] synonym: "aging-dependent sterility" NARROW [] synonym: "chromatin silencing at HML and HMR" NARROW [] synonym: "heterochromatic silencing at silent mating-type cassette" EXACT [] synonym: "silent mating-type cassette chromatin silencing" EXACT [GOC:mah] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0030470 name: obsolete spore germination (sensu Fungi) namespace: biological_process alt_id: GO:0007153 def: "OBSOLETE. Process of breakdown or opening of the spore-containing structure, modification of the spore wall, and resumption of growth of the spore. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [GOC:mcc] comment: This term was made obsolete because a sensu term was not needed. synonym: "germination (sensu Saccharomyces)" NARROW [] synonym: "spore germination (sensu Fungi)" EXACT [] is_obsolete: true replaced_by: GO:0009847 [Term] id: GO:0030471 name: obsolete spindle pole body and microtubule cycle (sensu Fungi) namespace: biological_process alt_id: GO:0007102 def: "OBSOLETE. The dynamics of the spindle pole body and microtubule cytoskeleton during the cell cycle. Includes spindle pole body duplication and separation and formation and elongation of the mitotic spindle. As in, but not restricted to, the fungi (Fungi, ncbi_taxonomy_id:4751)." [ISBN:0879693649] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. synonym: "spindle pole body and microtubule cycle (sensu Fungi)" EXACT [] synonym: "spindle pole body and microtubule cycle (sensu Saccharomyces)" NARROW [] is_obsolete: true consider: GO:0007051 consider: GO:0051300 [Term] id: GO:0030473 name: nuclear migration along microtubule namespace: biological_process alt_id: GO:0000065 def: "The directed movement of the nucleus along microtubules within the cell, mediated by motor proteins." [GOC:mah, GOC:sgd_curators] synonym: "microtubule cytoskeleton-dependent nuclear positioning" EXACT [] synonym: "microtubule cytoskeleton-dependent nucleus positioning" EXACT [] synonym: "microtubule-dependent nuclear positioning" EXACT [] synonym: "microtubule-dependent nucleus positioning" EXACT [] synonym: "microtubule-mediated nuclear migration" EXACT [] synonym: "nuclear migration, microtubule-mediated" EXACT [] synonym: "nuclear movement, microtubule-mediated" BROAD [] synonym: "nucleus migration" BROAD [] synonym: "transport of nucleus by microtubules" EXACT [] synonym: "transport of nucleus, microtubule-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0030474 name: spindle pole body duplication namespace: biological_process alt_id: GO:0007103 alt_id: GO:0031046 def: "Construction of a new spindle pole body." [GOC:clt] synonym: "spindle pole body assembly" EXACT [] synonym: "spindle pole body biogenesis" EXACT [] synonym: "spindle pole body biosynthesis" EXACT [] synonym: "spindle pole body duplication associated with nuclear envelope" EXACT [] synonym: "spindle pole body duplication in cytoplasm" EXACT [] synonym: "spindle pole body formation" EXACT [] synonym: "spindle pole body replication" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0051300 ! spindle pole body organization [Term] id: GO:0030476 name: ascospore wall assembly namespace: biological_process alt_id: GO:0007152 def: "The aggregation, arrangement and bonding together of a set of components to form an ascospore wall. During sporulation in Ascomycota, each ascospore nucleus becomes surrounded by a specialized spore wall, formed by deposition of spore wall components in the lumenal space between the outer and inner leaflets of the prospore membrane. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:14702385] synonym: "spore wall assembly" BROAD [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0042244 ! spore wall assembly is_a: GO:0071940 ! fungal-type cell wall assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0070591 ! ascospore wall biogenesis [Term] id: GO:0030478 name: actin cap namespace: cellular_component alt_id: GO:0000143 def: "Polarized accumulation of cytoskeletal proteins (including F-actin) and regulatory proteins in a cell. An example of this is the actin cap found in Saccharomyces cerevisiae." [GOC:mah, ISBN:10652251] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030479 name: actin cortical patch namespace: cellular_component alt_id: GO:0005857 def: "An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae." [GOC:mah, GOC:vw, ISBN:0879693568, ISBN:0879693649, PMID:16959963] synonym: "actin patch" EXACT [] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0061645 ! endocytic patch relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0030484 name: obsolete muscle fiber namespace: cellular_component def: "OBSOLETE. The contractile fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle." [GOC:mah, ISBN:0815316194] comment: This term was made obsolete because a muscle fiber is a cell type rather than a cell component. To update annotations, consider the external ontology term 'muscle cell ; CL:0000187'. synonym: "muscle fiber" EXACT [] synonym: "muscle fibre" EXACT [] is_obsolete: true consider: GO:0043292 [Term] id: GO:0030485 name: smooth muscle contractile fiber namespace: cellular_component def: "The contractile fiber of smooth muscle cells." [GOC:mah] synonym: "smooth muscle fiber" BROAD [] synonym: "smooth muscle fibre" EXACT [] is_a: GO:0043292 ! contractile fiber is_a: GO:0044449 ! contractile fiber part [Term] id: GO:0030486 name: smooth muscle dense body namespace: cellular_component def: "Electron-dense region associated with a smooth muscle contractile fiber." [GOC:mah, ISBN:0815316194] is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030485 ! smooth muscle contractile fiber [Term] id: GO:0030487 name: inositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [GOC:mah] xref: EC:3.1.3 is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0030488 name: tRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in a tRNA molecule." [GOC:mah] is_a: GO:0001510 ! RNA methylation is_a: GO:0006400 ! tRNA modification [Term] id: GO:0030489 name: obsolete processing of 27S pre-rRNA namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:curators] comment: This term was made obsolete because it was not defined and did not correspond to the production of a single specific mature rRNA product. synonym: "processing of 27S pre-rRNA" EXACT [] is_obsolete: true [Term] id: GO:0030490 name: maturation of SSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule." [GOC:curators] synonym: "processing of 20S pre-rRNA" NARROW [] synonym: "SSU-rRNA maturation" EXACT [GOC:dph, GOC:tb] is_a: GO:0006364 ! rRNA processing relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0030491 name: heteroduplex formation namespace: biological_process def: "The formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:10357855] is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0030492 name: hemoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with hemoglobin, an oxygen carrying, conjugated protein containing four heme groups and globin." [CHEBI:35143, GOC:jl] synonym: "globin binding" BROAD [] synonym: "haemoglobin binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0030493 name: bacteriochlorophyll metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] synonym: "bacteriochlorophyll metabolism" EXACT [] is_a: GO:0015994 ! chlorophyll metabolic process [Term] id: GO:0030494 name: bacteriochlorophyll biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:mah, ISBN:0198506732] synonym: "bacteriochlorophyll anabolism" EXACT [] synonym: "bacteriochlorophyll biosynthesis" EXACT [] synonym: "bacteriochlorophyll formation" EXACT [] synonym: "bacteriochlorophyll synthesis" EXACT [] is_a: GO:0015995 ! chlorophyll biosynthetic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030495 name: bacteriochlorophyll catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of bacteriochlorophyll, any of the chlorophylls of photosynthetic bacteria. They differ structurally from the chlorophylls of higher plants." [GOC:go_curators] synonym: "bacteriochlorophyll breakdown" EXACT [] synonym: "bacteriochlorophyll catabolism" EXACT [] synonym: "bacteriochlorophyll degradation" EXACT [] is_a: GO:0015996 ! chlorophyll catabolic process is_a: GO:0030493 ! bacteriochlorophyll metabolic process [Term] id: GO:0030496 name: midbody namespace: cellular_component def: "A thin cytoplasmic bridge formed between daughter cells at the end of cytokinesis. The midbody forms where the contractile ring constricts, and may persist for some time before finally breaking to complete cytokinesis." [ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Midbody_(cell_biology) is_a: GO:0044464 ! cell part [Term] id: GO:0030497 name: fatty acid elongation namespace: biological_process def: "The elongation of a fatty acid chain by the sequential addition of two-carbon units." [ISBN:0716720094] is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0030500 name: regulation of bone mineralization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of bone mineralization." [GOC:go_curators] is_a: GO:0030278 ! regulation of ossification is_a: GO:0070167 ! regulation of biomineral tissue development relationship: regulates GO:0030282 ! bone mineralization [Term] id: GO:0030501 name: positive regulation of bone mineralization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "activation of bone mineralization" NARROW [] synonym: "stimulation of bone mineralization" NARROW [] synonym: "up regulation of bone mineralization" EXACT [] synonym: "up-regulation of bone mineralization" EXACT [] synonym: "upregulation of bone mineralization" EXACT [] is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0045778 ! positive regulation of ossification is_a: GO:0070169 ! positive regulation of biomineral tissue development relationship: positively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030502 name: negative regulation of bone mineralization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of bone mineralization." [GOC:go_curators] synonym: "down regulation of bone mineralization" EXACT [] synonym: "down-regulation of bone mineralization" EXACT [] synonym: "downregulation of bone mineralization" EXACT [] synonym: "inhibition of bone mineralization" NARROW [] is_a: GO:0030279 ! negative regulation of ossification is_a: GO:0030500 ! regulation of bone mineralization is_a: GO:0070168 ! negative regulation of biomineral tissue development relationship: negatively_regulates GO:0030282 ! bone mineralization [Term] id: GO:0030504 name: inorganic diphosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of inorganic diphosphate across a membrane." [PMID:11326272] synonym: "inorganic pyrophosphate transporter activity" EXACT [] xref: reactome:R-HSA-5226964 "ANKH transports PPi from cytosol to extracellular region" is_a: GO:0015103 ! inorganic anion transmembrane transporter activity [Term] id: GO:0030505 name: inorganic diphosphate transport namespace: biological_process def: "The directed movement of inorganic diphosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "inorganic pyrophosphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0030506 name: ankyrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with ankyrin, a 200 kDa cytoskeletal protein that attaches other cytoskeletal proteins to integral membrane proteins." [GOC:mah, ISBN:0198506732] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030507 name: spectrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with spectrin, a protein that is the major constituent of the erythrocyte cytoskeletal network. It associates with band 4.1 (see band protein) and actin to form the cytoskeletal superstructure of the erythrocyte plasma membrane. It is composed of nonhomologous chains, alpha and beta, which aggregate side-to-side in an antiparallel fashion to form dimers, tetramers, and higher polymers." [GOC:mah, ISBN:0198506732] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0030508 name: obsolete thiol-disulfide exchange intermediate activity namespace: molecular_function def: "OBSOLETE. Functions as an exchange intermediate in thiol-disulfide exchange reactions." [GOC:kd, GOC:mah] comment: This term was made obsolete because it represents a combination of gene product features and involvement in a biological process. synonym: "glutaredoxin" NARROW [] synonym: "thiol-disulfide exchange intermediate activity" EXACT [] synonym: "thiol-disulphide exchange intermediate activity" EXACT [] synonym: "thioredoxin" NARROW [] is_obsolete: true consider: GO:0003756 consider: GO:0015036 [Term] id: GO:0030509 name: BMP signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a member of the BMP (bone morphogenetic protein) family to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:signaling, ISBN:0878932437, PR:000000034] synonym: "BMP receptor signaling pathway" RELATED [] synonym: "BMP signalling pathway" EXACT [] synonym: "bone morphogenetic protein signaling pathway" EXACT [] synonym: "bone morphogenetic protein signalling pathway" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway relationship: part_of GO:0071773 ! cellular response to BMP stimulus [Term] id: GO:0030510 name: regulation of BMP signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any BMP receptor signaling pathway." [GOC:mah] synonym: "regulation of BMP receptor signaling pathway" RELATED [] synonym: "regulation of BMP signalling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "regulation of bone morphogenetic protein signalling pathway" EXACT [] is_a: GO:0006357 ! regulation of transcription by RNA polymerase II is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus relationship: regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030511 name: positive regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TGF-beta receptor signaling pathway activity." [GOC:go_curators] synonym: "activation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "positive regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "positive regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "positive regulation of transforming growth factor beta receptor signalling pathway" EXACT [] synonym: "stimulation of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "up regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "up-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "upregulation of transforming growth factor beta receptor signaling pathway" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903846 ! positive regulation of cellular response to transforming growth factor beta stimulus relationship: positively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030512 name: negative regulation of transforming growth factor beta receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway." [GOC:mah] synonym: "down regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "down-regulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "downregulation of transforming growth factor beta receptor signaling pathway" EXACT [] synonym: "inhibition of transforming growth factor beta receptor signaling pathway" NARROW [] synonym: "negative regulation of TGF-beta receptor signaling pathway" EXACT [] synonym: "negative regulation of TGFbeta receptor signaling pathway" EXACT [] synonym: "negative regulation of transforming growth factor beta receptor signalling pathway" EXACT [] is_a: GO:0017015 ! regulation of transforming growth factor beta receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:1903845 ! negative regulation of cellular response to transforming growth factor beta stimulus relationship: negatively_regulates GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0030513 name: positive regulation of BMP signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of BMP signaling pathway activity." [GOC:go_curators] synonym: "activation of BMP signaling pathway" NARROW [] synonym: "positive regulation of BMP receptor signaling pathway" RELATED [] synonym: "positive regulation of BMP signalling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "positive regulation of bone morphogenetic protein signalling pathway" EXACT [] synonym: "stimulation of BMP signaling pathway" NARROW [] synonym: "up regulation of BMP signaling pathway" EXACT [] synonym: "up-regulation of BMP signaling pathway" EXACT [] synonym: "upregulation of BMP signaling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030514 name: negative regulation of BMP signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway." [GOC:go_curators] synonym: "down regulation of BMP signaling pathway" EXACT [] synonym: "down-regulation of BMP signaling pathway" EXACT [] synonym: "downregulation of BMP signaling pathway" EXACT [] synonym: "inhibition of BMP signaling pathway" NARROW [] synonym: "negative regulation of BMP receptor signaling pathway" RELATED [] synonym: "negative regulation of BMP signalling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signaling pathway" EXACT [] synonym: "negative regulation of bone morphogenetic protein signalling pathway" EXACT [] is_a: GO:0030510 ! regulation of BMP signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus relationship: negatively_regulates GO:0030509 ! BMP signaling pathway [Term] id: GO:0030515 name: snoRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with small nucleolar RNA." [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0030516 name: regulation of axon extension namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon extension." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0050770 ! regulation of axonogenesis is_a: GO:0061387 ! regulation of extent of cell growth relationship: regulates GO:0048675 ! axon extension [Term] id: GO:0030517 name: negative regulation of axon extension namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of axon outgrowth." [GOC:mah] synonym: "down regulation of axon extension" EXACT [] synonym: "down-regulation of axon extension" EXACT [] synonym: "downregulation of axon extension" EXACT [] synonym: "inhibition of axon extension" NARROW [] is_a: GO:0030308 ! negative regulation of cell growth is_a: GO:0030516 ! regulation of axon extension is_a: GO:0048640 ! negative regulation of developmental growth is_a: GO:0050771 ! negative regulation of axonogenesis relationship: negatively_regulates GO:0048675 ! axon extension [Term] id: GO:0030518 name: intracellular steroid hormone receptor signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a intracellular steroid hormone receptor binding to one of its physiological ligands." [GOC:mah, GOC:signaling] synonym: "steroid hormone receptor signaling pathway" BROAD [GOC:bf] synonym: "steroid hormone receptor signalling pathway" BROAD [GOC:bf] is_a: GO:0030522 ! intracellular receptor signaling pathway is_a: GO:0043401 ! steroid hormone mediated signaling pathway [Term] id: GO:0030519 name: snoRNP binding namespace: molecular_function def: "Interacting selectively and non-covalently with any part of a small nucleolar ribonucleoprotein particle." [GOC:mah] is_a: GO:0043021 ! ribonucleoprotein complex binding [Term] id: GO:0030520 name: intracellular estrogen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an intracellular estrogen receptor binding to one of its physiological ligands. The pathway begins with receptor-ligand binding, and ends with regulation of a downstream cellular process (e.g. transcription)." [GOC:mah, GOC:signaling] synonym: "estrogen receptor signaling pathway" BROAD [GOC:bf] synonym: "estrogen receptor signalling pathway" BROAD [GOC:bf] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0030521 name: androgen receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an androgen binding to its receptor." [GOC:mah] synonym: "androgen receptor signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0030522 name: intracellular receptor signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by a ligand binding to an receptor located within a cell." [GOC:bf, GOC:mah] synonym: "intracellular receptor mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signaling pathway" EXACT [] synonym: "intracellular receptor-mediated signalling pathway" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0030523 name: dihydrolipoamide S-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide." [EC:2.3.1.12, GOC:mah] is_a: GO:0016417 ! S-acyltransferase activity [Term] id: GO:0030526 name: granulocyte macrophage colony-stimulating factor receptor complex namespace: cellular_component def: "The heterodimeric receptor for granulocyte macrophage colony-stimulating factor." [GOC:mah] synonym: "GM-CSF receptor complex" EXACT [GOC:vk] synonym: "granulocyte macrophage colony stimulating factor receptor complex" EXACT [] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030527 name: structural constituent of chromatin namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of chromatin." [GOC:ai] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0030528 name: obsolete transcription regulator activity namespace: molecular_function def: "OBSOLETE. Plays a role in regulating transcription; may bind a promoter or enhancer DNA sequence or interact with a DNA-binding transcription factor." [GOC:mah] comment: This term was obsoleted because it is essentially identical to a Process term (specifically the Biological Process term which has been selected as a term to consider for reannotation), i.e. it is defined only in terms of the process it acts in and it does NOT convey any information about the molecular nature of the function or whether the function is based on binding DNA, on interacting with other proteins, or some other mechanism. To transfer all annotations without review, the BP term indicated is considered to be equivalent and thus the only appropriate destination for all annotations. To reannotate to a MF term, you will probably need to revisit the original literature or other primary data because this "MF" term was not defined in terms of mechanism of action and there are multiple possibilities in the revised MF structure. In reannotation, please also consider descendent terms of the suggested MF terms as a more specific term may be more appropriate than the MF terms indicated. Please be aware that you may wish to request a new term if the mechanism of action of this gene product is not yet represented or if you are annotating for an RNAP different than one for which there is a specific suggested term. Also note that if there is no information about how the gene product acts, it may be appropriate to annotate to the root term for molecular_function. synonym: "transcription regulator activity" EXACT [] synonym: "transcriptional regulator activity" EXACT [] is_obsolete: true replaced_by: GO:0140110 [Term] id: GO:0030530 name: obsolete heterogeneous nuclear ribonucleoprotein complex namespace: cellular_component def: "OBSOLETE. Particulate complex of heterogeneous nuclear RNA (hnRNA; a heterogeneous mixture of RNA molecules of high Mr with a rapid turnover rate that occurs in cell nuclei during protein synthesis; it is the form of RNA synthesized in eukaryotes by RNA polymerase II, that which is translated into protein) with protein, which is cell-specific and heterogeneous. The protein component may play a role in the processing of the hnRNA to mRNA." [ISBN:0198506732] comment: This term was made because heterogeneous nuclear ribonucleoprotein is an experimental construct and does not correspond cleanly to a functional cellular entity. synonym: "heterogeneous nuclear ribonucleoprotein" EXACT [] synonym: "heterogeneous nuclear ribonucleoprotein complex" EXACT [] synonym: "hnRNP" EXACT [] xref: Wikipedia:Heterogeneous_ribonucleoprotein_particle is_obsolete: true consider: GO:0005681 consider: GO:1990904 [Term] id: GO:0030531 name: obsolete small cytoplasmic ribonucleoprotein complex namespace: cellular_component def: "OBSOLETE. A complex composed of RNA of the small cytoplasmic RNA (scRNA) class and protein, found in the cytoplasm." [GOC:krc, GOC:mah] comment: This term was made obsolete because we are unsure what it is supposed to represent, it has no annotations and the only references to the phrase in the literature are old. synonym: "scRNP" EXACT [] synonym: "small cytoplasmic ribonucleoprotein" EXACT [] synonym: "small cytoplasmic ribonucleoprotein complex" EXACT [] is_obsolete: true replaced_by: GO:1990904 [Term] id: GO:0030532 name: small nuclear ribonucleoprotein complex namespace: cellular_component def: "A complex composed of RNA of the small nuclear RNA (snRNA) class and protein, found in the nucleus of a eukaryotic cell. These are typically named after the snRNA(s) they contain, e.g. U1 snRNP or U4/U6 snRNP. Many, but not all, of these complexes are involved in splicing of nuclear mRNAs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nuclear ribonucleoprotein" EXACT [] synonym: "snRNP" EXACT [] xref: Wikipedia:SnRNP is_a: GO:0044428 ! nuclear part is_a: GO:0120114 ! Sm-like protein family complex is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030533 name: triplet codon-amino acid adaptor activity namespace: molecular_function def: "The codon binding activity of a tRNA that positions an activated amino acid, mediating its insertion at the correct point in the sequence of a nascent polypeptide chain during protein synthesis." [GOC:hjd, GOC:mtg_MIT_16mar07, ISBN:0198506732] comment: Note that this term can be used in place of the obsolete term 'transfer RNA ; GO:0005563'. subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "transfer RNA" RELATED [] synonym: "tRNA" RELATED [] is_a: GO:0003729 ! mRNA binding is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0030534 name: adult behavior namespace: biological_process def: "Behavior in a fully developed and mature organism." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "adult behavioral response to stimulus" EXACT [] synonym: "adult behaviour" EXACT [] synonym: "adult behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030535 name: obsolete adult feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in a fully developed and mature organism, as described in insects." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. synonym: "adult feeding behavior (sensu Insecta)" EXACT [] is_obsolete: true replaced_by: GO:0008343 [Term] id: GO:0030536 name: larval feeding behavior namespace: biological_process def: "Feeding behavior in a larval (immature) organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "larval feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0030537 name: larval behavior namespace: biological_process alt_id: GO:0017037 def: "Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics." [GOC:mah, ISBN:0877797099] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "larval behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0030538 name: embryonic genitalia morphogenesis namespace: biological_process def: "The process, occurring in the embryo, by which the anatomical structures of the genitalia are generated and organized." [GOC:bf] synonym: "embryonic genital morphogenesis" RELATED [] is_a: GO:0035112 ! genitalia morphogenesis is_a: GO:0048562 ! embryonic organ morphogenesis [Term] id: GO:0030539 name: male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from its formation to the mature structure." [GOC:ems, ISBN:0140512888] synonym: "male genital development" EXACT [] is_a: GO:0048806 ! genitalia development is_a: GO:0061458 ! reproductive system development relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0030540 name: female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation to the mature structure." [GOC:mah] synonym: "female genital development" EXACT [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0046660 ! female sex differentiation [Term] id: GO:0030541 name: plasmid partitioning namespace: biological_process alt_id: GO:0030542 def: "Any process in which plasmids are segregated or distributed into daughter cells upon cell division." [GOC:mah] is_a: GO:0006276 ! plasmid maintenance [Term] id: GO:0030543 name: 2-micrometer plasmid partitioning namespace: biological_process def: "The process in which copies of the 2-micrometer plasmid, found in fungi such as Saccharomyces, are distributed to daughter cells upon cell division." [GOC:mah] is_a: GO:0030541 ! plasmid partitioning [Term] id: GO:0030544 name: Hsp70 protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Hsp70 proteins, any of a group of heat shock proteins around 70kDa in size." [ISBN:0198506732] is_a: GO:0031072 ! heat shock protein binding [Term] id: GO:0030545 name: receptor regulator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is changed." [GOC:ceb] is_a: GO:0098772 ! molecular function regulator [Term] id: GO:0030546 name: receptor activator activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is increased." [GOC:ceb] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030547 name: receptor inhibitor activity namespace: molecular_function def: "The function of interacting (directly or indirectly) with receptors such that the proportion of receptors in the active form is decreased." [GOC:ceb] is_a: GO:0030545 ! receptor regulator activity [Term] id: GO:0030548 name: acetylcholine receptor regulator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is changed." [GOC:mah] is_a: GO:0099602 ! neurotransmitter receptor regulator activity [Term] id: GO:0030549 name: acetylcholine receptor activator activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is increased." [GOC:mah] is_a: GO:0030546 ! receptor activator activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030550 name: acetylcholine receptor inhibitor activity namespace: molecular_function def: "Interacting (directly or indirectly) with acetylcholine receptors such that the proportion of receptors in the active form is decreased." [GOC:mah] is_a: GO:0030547 ! receptor inhibitor activity is_a: GO:0030548 ! acetylcholine receptor regulator activity [Term] id: GO:0030551 name: cyclic nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:ai] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0030552 name: cAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cAMP binding" EXACT [] synonym: "3',5'-cAMP binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate binding" EXACT [] synonym: "cyclic AMP binding" EXACT [] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032559 ! adenyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0030553 name: cGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with cGMP, the nucleotide cyclic GMP (guanosine 3',5'-cyclophosphate)." [GOC:ai] synonym: "3',5' cGMP binding" EXACT [] synonym: "3',5'-cGMP binding" EXACT [] synonym: "cyclic GMP binding" EXACT [] is_a: GO:0030551 ! cyclic nucleotide binding is_a: GO:0032561 ! guanyl ribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0030554 name: adenyl nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenyl nucleotides, any compound consisting of adenosine esterified with (ortho)phosphate." [ISBN:0198506732] subset: goslim_chembl is_a: GO:0017076 ! purine nucleotide binding [Term] id: GO:0030555 name: RNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. subset: goslim_generic subset: goslim_yeast is_a: GO:0003723 ! RNA binding [Term] id: GO:0030556 name: rRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0019843 ! rRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030557 name: tRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0000049 ! tRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030558 name: RNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030559 name: rRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030560 name: tRNA pseudouridylation guide activity namespace: molecular_function def: "Specifies the site of pseudouridylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030558 ! RNA pseudouridylation guide activity [Term] id: GO:0030561 name: RNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an RNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030562 name: rRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in an rRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030556 ! rRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030563 name: snRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Activity that provides specificity to a methylase by using base complementarity to guide site-specific 2'-O-ribose methylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030564 name: tRNA 2'-O-ribose methylation guide activity namespace: molecular_function def: "Specifies the site of 2'-O-ribose methylation in a tRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0030557 ! tRNA modification guide activity is_a: GO:0030561 ! RNA 2'-O-ribose methylation guide activity [Term] id: GO:0030565 name: snRNA pseudouridylation guide activity namespace: molecular_function def: "Activity that provides specificity to a pseudouridine synthetase by using base complementarity to guide site-specific pseudouridylations to a small nuclear RNA molecule." [PMID:11733745] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. Note that this term may be useful for annotating snoRNAs. is_a: GO:0030558 ! RNA pseudouridylation guide activity is_a: GO:0030566 ! snRNA modification guide activity [Term] id: GO:0030566 name: snRNA modification guide activity namespace: molecular_function def: "Specifies the site of a posttranscriptional modification in an snRNA molecule by base pairing with a short sequence around the target residue." [GOC:mah, PMID:12457565] comment: Note that this term describes the activity of a nucleic acid, usually RNA, gene product that interacts with other RNA molecules via base pairing; it should not be used to annotate proteins. is_a: GO:0017069 ! snRNA binding is_a: GO:0030555 ! RNA modification guide activity [Term] id: GO:0030567 name: obsolete thrombin activator activity namespace: molecular_function def: "OBSOLETE. Increases the rate of proteolysis catalyzed by thrombin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "prothrombin activator activity" RELATED [GOC:dph, GOC:tb] synonym: "thrombin activator activity" EXACT [] is_obsolete: true replaced_by: GO:0016504 [Term] id: GO:0030568 name: obsolete plasmin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase plasmin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "plasmin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030569 name: obsolete chymotrypsin inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the serine endopeptidase chymotrypsin." [GOC:mah] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function term. synonym: "chymotrypsin inhibitor activity" EXACT [] is_obsolete: true replaced_by: GO:0004867 [Term] id: GO:0030570 name: pectate lyase activity namespace: molecular_function def: "Catalysis of the reaction: a pectate = a pectate + a pectate oligosaccharide with 4-(4-deoxy-alpha-D-galact-4-enuronosyl)-D-galacturonate end. This reaction is the eliminative cleavage of pectate to give oligosaccharides with 4-deoxy-alpha-D-gluc-4-enuronosyl groups at their non-reducing ends." [EC:4.2.2.2] synonym: "(1->4)-alpha-D-galacturonan lyase activity" EXACT [EC:4.2.2.2] synonym: "alpha-1,4-D-endopolygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endo-alpha-1,4-polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "endogalacturonate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "endopectin methyltranseliminase activity" EXACT [EC:4.2.2.2] synonym: "pectate transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "pectic acid transeliminase activity" EXACT [EC:4.2.2.2] synonym: "pectic lyase activity" BROAD [EC:4.2.2.2] synonym: "pectin trans-eliminase activity" BROAD [EC:4.2.2.2] synonym: "PGA lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonate lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid lyase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic acid trans-eliminase activity" EXACT [EC:4.2.2.2] synonym: "polygalacturonic transeliminase activity" EXACT [EC:4.2.2.2] synonym: "PPase-N activity" EXACT [EC:4.2.2.2] xref: EC:4.2.2.2 xref: MetaCyc:4.2.2.2-RXN is_a: GO:0016837 ! carbon-oxygen lyase activity, acting on polysaccharides [Term] id: GO:0030572 name: phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction involving the transfer of a phosphatidate (otherwise known as diacylglycerol 3-phosphosphate) group." [GOC:mb] is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0030573 name: bile acid catabolic process namespace: biological_process alt_id: GO:0019613 def: "The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid 7alpha-dehydroxylation pathway" NARROW [] synonym: "bile acid breakdown" EXACT [] synonym: "bile acid catabolism" EXACT [] synonym: "bile acid degradation" EXACT [] synonym: "cholate catabolic process" NARROW [] xref: MetaCyc:7ALPHADEHYDROX-PWY is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0072329 ! monocarboxylic acid catabolic process [Term] id: GO:0030574 name: collagen catabolic process namespace: biological_process def: "The proteolytic chemical reactions and pathways resulting in the breakdown of collagen in the extracellular matrix, usually carried out by proteases secreted by nearby cells." [GOC:mah, ISBN:0815316194] synonym: "collagen breakdown" EXACT [] synonym: "collagen catabolism" EXACT [] synonym: "collagen degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0032963 ! collagen metabolic process [Term] id: GO:0030575 name: nuclear body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of any of the extra-nucleolar nuclear domains usually visualized by confocal microscopy and fluorescent antibodies to specific proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "nuclear body organisation" EXACT [GOC:curators] synonym: "nuclear body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0030576 name: Cajal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Cajal bodies, nuclear bodies that appear ultrastructurally as a tangle of coiled, electron-dense threads roughly 0.5 micrometers in diameter and are enriched in ribonucleoproteins, and certain general RNA polymerase II transcription factors." [GOC:mah, PMID:11031238] comment: See also the cellular component term 'Cajal body ; GO:0015030'. synonym: "Cajal body organisation" EXACT [GOC:curators] synonym: "Cajal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030577 name: Lands organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of Lands, a class of nuclear body that react against SP140 auto-antibodies." [GOC:mah, PMID:10921892, PMID:8695863] comment: See also the cellular component term 'Lands ; GO:0016606'. synonym: "Lands organisation" EXACT [GOC:curators] synonym: "Lands organization and biogenesis" RELATED [GOC:mah] synonym: "LYSP100-associated nuclear domain organization" EXACT [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030578 name: PML body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of PML bodies, a class of nuclear body; they react against SP100 auto-antibodies (PML = promyelocytic leukemia)." [GOC:mah, PMID:10806078] comment: See also the cellular component term 'PML body ; GO:0016605'. synonym: "PML body organisation" EXACT [GOC:curators] synonym: "PML body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030575 ! nuclear body organization [Term] id: GO:0030579 name: ubiquitin-dependent SMAD protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of SMAD signaling proteins by ubiquitination and targeting to the proteasome." [GOC:go_curators] synonym: "ubiquitin-dependent SMAD protein breakdown" EXACT [] synonym: "ubiquitin-dependent SMAD protein catabolism" EXACT [] synonym: "ubiquitin-dependent SMAD protein degradation" EXACT [] is_a: GO:0006511 ! ubiquitin-dependent protein catabolic process relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0030580 name: quinone cofactor methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosylmethionine during the synthesis of quinone cofactors such as ubiquinone (coenzyme Q), menaquinone (vitamin K2), plastoquinone and phylloquinone (vitamin K1)." [GOC:mb] is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030581 name: symbiont intracellular protein transport in host namespace: biological_process def: "The directed movement of a symbiont's proteins within a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mb] synonym: "host cell protein transport" EXACT [] synonym: "intracellular protein transport in host" EXACT [] is_a: GO:0051701 ! interaction with host is_a: GO:0051708 ! intracellular protein transport in other organism involved in symbiotic interaction is_a: GO:1902583 ! multi-organism intracellular transport [Term] id: GO:0030582 name: reproductive fruiting body development namespace: biological_process def: "The process whose specific outcome is the progression of a reproductive fruiting body over time, from its formation to the mature structure. A reproductive fruiting body is a multicellular reproductive structure that contains spores." [GOC:mah, GOC:mtg_sensu] comment: This term describes the development of a fruiting body that is a spore-bearing organ. It is not intended to describe the development of myxococcal fruiting bodies. synonym: "fruiting body formation" EXACT [] is_a: GO:0075259 ! spore-bearing structure development [Term] id: GO:0030583 name: myxococcal fruiting body development namespace: biological_process alt_id: GO:0055084 def: "The process whose specific outcome is the progression of the myxococcal fruiting body over time, from its formation to the mature structure. The process begins when myxococci respond to a lack of nutrients in the environment and ends when the myxococcal fruiting body is a mature structure." [GOC:mtg_sensu, ISBN:0815316194, PMID:11121786] comment: For example, as seen in myxobacterium. It is not intended to describe fruiting body development as is Dictyostelium. synonym: "fruiting body development in cellular response to starvation" BROAD [] synonym: "fruiting body development in response to starvation" BROAD [] is_a: GO:0042594 ! response to starvation is_a: GO:0044764 ! multi-organism cellular process [Term] id: GO:0030584 name: sporocarp development namespace: biological_process def: "The process whose specific outcome is the progression of a sporocarp over time, from its formation to the mature structure. The sporocarp is a spore bearing fruiting body organ. An example of this process is found in the Fungal species Coprinopsis cinerea." [GOC:mah, GOC:mtg_sensu] synonym: "fruiting body development" BROAD [] is_a: GO:0030582 ! reproductive fruiting body development [Term] id: GO:0030585 name: phosphoenolpyruvate carboxykinase (diphosphate) activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + oxaloacetate = CO(2) + phosphate + phosphoenolpyruvate." [EC:4.1.1.38, RHEA:22356] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.38] synonym: "diphosphate:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.38] synonym: "PEP carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "PEPCTrP" RELATED [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxykinase (pyrophosphate) activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxyphosphotransferase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvate carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphoenolpyruvic carboxytransphosphorylase activity" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.38] synonym: "phosphopyruvate carboxykinase (pyrophosphate)" EXACT [EC:4.1.1.38] synonym: "phosphopyruvate carboxylase (pyrophosphate)" EXACT [EC:4.1.1.38] xref: EC:4.1.1.38 xref: KEGG:R00346 xref: MetaCyc:4.1.1.38-RXN xref: RHEA:22356 is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0030586 name: [methionine synthase] reductase activity namespace: molecular_function def: "Catalysis of the reaction: [methionine synthase]-cob(II)alamin + NADPH + H+ + S-adenosyl methionine = [methionine synthase]-methylcob(I)alamin + S-adenosylhomocysteine + NADP+." [EC:1.16.1.8] comment: Note that this was EC:2.1.1.135. synonym: "5-methyltetrahydrofolate-homocysteine methyltransferase reductase" RELATED [] synonym: "[methionine synthase]-cobalamin methyltransferase (cob(II)alamin reducing) activity" EXACT [] synonym: "methionine synthase cob(II)alamin reductase (methylating) activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase reductase activity" EXACT [EC:1.16.1.8] synonym: "methionine synthase-cobalamin methyltransferase (cob(II)alamin reducing)" EXACT [EC:1.16.1.8] synonym: "methionine synthase-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase activity" EXACT [EC:1.16.1.8] xref: EC:1.16.1.8 xref: MetaCyc:2.1.1.135-RXN xref: reactome:R-HSA-3149518 "MTRR reduces cob(II)alamin to meCbl" is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0030587 name: sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp over time, from its formation to the mature structure. The process begins with the aggregation of individual cells and ends with the mature sorocarp. The sorocarp is a structure containing a spore-bearing sorus that sits on top of a stalk. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530, GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "fruiting body development" BROAD [] synonym: "fruiting body formation" BROAD [] synonym: "sorocarp biosynthesis" EXACT [] synonym: "sorocarp formation" EXACT [] is_a: GO:0090702 ! non-reproductive fruiting body development [Term] id: GO:0030588 name: pseudocleavage namespace: biological_process def: "Partial constriction of the cytoplasm of an embryo to form a furrow that resembles a cleavage furrow but does not complete cytokinesis." [GOC:mah, PMID:10751167, PMID:7729583] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0030589 name: pseudocleavage involved in syncytial blastoderm formation namespace: biological_process def: "Formation of furrows in the cytoplasm between nuclei during cell cycles in embryos that contribute to the formation of the syncytial blastoderm. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "pseudocleavage during syncytial blastoderm formation" RELATED [GOC:dph] is_a: GO:0030588 ! pseudocleavage relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0030590 name: first cell cycle pseudocleavage namespace: biological_process def: "A process that occurs during the first cell cycle in an embryo, in which anterior cortical contractions culminate in a single partial constriction of the embryo called the pseudocleavage furrow. An example of this process is found in nematode worms." [GOC:mtg_sensu, PMID:7729583] is_a: GO:0030588 ! pseudocleavage [Term] id: GO:0030591 name: 2'-deoxyguanosine DNA ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of the ADP-ribose group of NAD+ to the amino group at N2 of 2'-deoxyguanosine to yield N2-(alpha-ADP-ribos-1-yl)-2'-deoxyguanosine and its beta form." [PMID:11592983] synonym: "NAD DNA ADP-ribosyltransferase activity" BROAD [] is_a: GO:0140294 ! NAD DNA ADP-ribosyltransferase activity [Term] id: GO:0030592 name: DNA ADP-ribosylation namespace: biological_process def: "The covalent attachment of an ADP-ribosyl group to a residue in double-stranded DNA." [PMID:11592983, PMID:27471034, PMID:29361132, PMID:29520010] comment: Updated definition as requested in https://github.com/geneontology/go-ontology/issues/16614 is_a: GO:0006304 ! DNA modification [Term] id: GO:0030593 name: neutrophil chemotaxis namespace: biological_process def: "The directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding." [GOC:jl, ISBN:0198506732] is_a: GO:0071621 ! granulocyte chemotaxis is_a: GO:1990266 ! neutrophil migration [Term] id: GO:0030594 name: neurotransmitter receptor activity namespace: molecular_function def: "Combining with a neurotransmitter and transmitting the signal to initiate a change in cell activity." [GOC:jl, GOC:signaling] comment: A strict definition of neurotransmitter receptor activity would limit its use to receptor activity at the postsynaptic membrane as part of synaptic transmission, but we recognize that usage is often much broader than this. For the strict use case, please see 'postsynaptic neurotransmitter receptor activity' is_a: GO:0038023 ! signaling receptor activity [Term] id: GO:0030595 name: leukocyte chemotaxis namespace: biological_process def: "The movement of a leukocyte in response to an external stimulus." [GOC:add, GOC:jl] synonym: "immune cell chemotaxis" EXACT [] synonym: "leucocyte chemotaxis" EXACT [] is_a: GO:0050900 ! leukocyte migration is_a: GO:0060326 ! cell chemotaxis [Term] id: GO:0030596 name: alpha-L-rhamnosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing alpha-L-rhamnose residues in alpha-L-rhamnosides." [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase N" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnosidase T" RELATED [EC:3.2.1.40] synonym: "alpha-L-rhamnoside rhamnohydrolase activity" EXACT [EC:3.2.1.40] xref: EC:3.2.1.40 xref: MetaCyc:3.2.1.40-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0030597 name: RNA glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-glycosidic bonds in an RNA molecule." [GOC:mah] is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds is_a: GO:0140098 ! catalytic activity, acting on RNA [Term] id: GO:0030598 name: rRNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the N-glycosylic bond at A-4324 in 28S rRNA from rat ribosomes or corresponding sites in 28S RNA from other species." [EC:3.2.2.22, GOC:mah] synonym: "gelonin" RELATED [EC:3.2.2.22] synonym: "mirabilis antiviral protein" RELATED [EC:3.2.2.22] synonym: "momorcochin-S" RELATED [EC:3.2.2.22] synonym: "nigrin b" RELATED [EC:3.2.2.22] synonym: "ribosomal ribonucleate N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "ricin" RELATED [EC:3.2.2.22] synonym: "RNA N-glycosidase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycohydrolase activity" EXACT [EC:3.2.2.22] synonym: "rRNA N-glycosidase activity" EXACT [] synonym: "saporins" RELATED [EC:3.2.2.22] xref: EC:3.2.2.22 xref: MetaCyc:3.2.2.22-RXN is_a: GO:0030597 ! RNA glycosylase activity is_a: GO:0140102 ! catalytic activity, acting on a rRNA [Term] id: GO:0030599 name: pectinesterase activity namespace: molecular_function def: "Catalysis of the reaction: pectin + n H2O = n methanol + pectate." [EC:3.1.1.11] synonym: "pectase activity" EXACT [EC:3.1.1.11] synonym: "pectin demethoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methoxylase activity" EXACT [EC:3.1.1.11] synonym: "pectin methyl esterase activity" EXACT [EC:3.1.1.11] synonym: "pectin methylesterase activity" EXACT [] synonym: "pectin pectylhydrolase activity" EXACT [EC:3.1.1.11] synonym: "pectinoesterase activity" EXACT [EC:3.1.1.11] xref: EC:3.1.1.11 xref: MetaCyc:PECTINESTERASE-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030600 name: feruloyl esterase activity namespace: molecular_function def: "Catalysis of the reaction: feruloyl-polysaccharide + H2O = ferulate + polysaccharide." [EC:3.1.1.73] synonym: "4-hydroxy-3-methoxycinnamoyl-sugar hydrolase activity" EXACT [EC:3.1.1.73] synonym: "cinnAE" RELATED [EC:3.1.1.73] synonym: "cinnamoyl ester hydrolase activity" EXACT [] synonym: "FAE-I" RELATED [EC:3.1.1.73] synonym: "FAE-II" RELATED [EC:3.1.1.73] synonym: "FAE-III" RELATED [EC:3.1.1.73] synonym: "FAEA" RELATED [EC:3.1.1.73] synonym: "ferulic acid esterase activity" EXACT [EC:3.1.1.73] synonym: "hemicellulase accessory" RELATED [EC:3.1.1.73] synonym: "hydroxycinnamoyl esterase activity" EXACT [EC:3.1.1.73] xref: EC:3.1.1.73 xref: MetaCyc:3.1.1.73-RXN is_a: GO:0052689 ! carboxylic ester hydrolase activity [Term] id: GO:0030601 name: obsolete aminopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal Arg and Lys from oligopeptides when P1' is not Pro. Also acts on arylamides of Arg and Lys." [EC:3.4.11.6] comment: This term was made obsolete because it represents a gene product. synonym: "aminopeptidase B activity" EXACT [] synonym: "arginyl aminopeptidase activity" EXACT [] synonym: "arylamidase II" RELATED [EC:3.4.11.6] synonym: "Cl--activated arginine aminopeptidase activity" EXACT [EC:3.4.11.6] synonym: "cytosol aminopeptidase IV" RELATED [EC:3.4.11.6] synonym: "L-arginine aminopeptidase activity" EXACT [EC:3.4.11.6] xref: EC:3.4.11.6 xref: MetaCyc:3.4.11.6-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0030602 name: obsolete chymosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the lysis of peptide bonds with broad specificity similar to that of pepsin A. Clots milk by cleavage of a single Ser-Phe-l-Met-Ala bond in kappa-casein." [EC:3.4.23.4] comment: This term was made obsolete because it represents a gene product. synonym: "chymosin activity" EXACT [] synonym: "rennin" RELATED [EC:3.4.23.4] synonym: "rennin (but this should be avoided since it leads to confusion with renin)" RELATED [EC:3.4.23.4] xref: EC:3.4.23.4 xref: MetaCyc:3.4.23.4-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0030603 name: oxaloacetase activity namespace: molecular_function def: "Catalysis of the reaction: H(2)O + oxaloacetate = acetate + H(+) + oxalate." [EC:3.7.1.1, RHEA:24432] synonym: "oxalacetic hydrolase activity" EXACT [EC:3.7.1.1] synonym: "oxaloacetate acetylhydrolase activity" EXACT [EC:3.7.1.1] xref: EC:3.7.1.1 xref: KEGG:R00338 xref: MetaCyc:OXALOACETASE-RXN xref: RHEA:24432 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0030604 name: 1-deoxy-D-xylulose-5-phosphate reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: 2-C-methyl-D-erythritol 4-phosphate + NADP(+) = 1-deoxy-D-xylulose 5-phosphate + H(+) + NADPH." [EC:1.1.1.267, RHEA:13717] synonym: "1-deoxy-D-xylulose-5-phosphate isomeroreductase activity" EXACT [EC:1.1.1.267] synonym: "1-deoxyxylulose-5-phosphate reductoisomerase activity" EXACT [EC:1.1.1.267] synonym: "2-C-methyl-D-erythritol-4-phosphate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.267] synonym: "2C-methyl-D-erythritol-4-phosphate (MEP) synthase activity" EXACT [EC:1.1.1.267] synonym: "DOXP reductoisomerase activity" EXACT [] synonym: "DXP-reductoisomerase activity" EXACT [EC:1.1.1.267] xref: EC:1.1.1.267 xref: KEGG:R05688 xref: MetaCyc:DXPREDISOM-RXN xref: RHEA:13717 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0030611 name: arsenate reductase activity namespace: molecular_function def: "Catalysis of the interconversion of arsenate and arsenite." [GOC:mah] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030612 name: arsenate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + thioredoxin = arsenite + thioredoxin disulfide. Thioredoxin disulfide is also known as oxidized thioredoxin." [MetaCyc:RXN-10737] xref: MetaCyc:RXN-10737 is_a: GO:0030611 ! arsenate reductase activity [Term] id: GO:0030613 name: oxidoreductase activity, acting on phosphorus or arsenic in donors namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor." [GOC:mah] comment: Note that enzymes of class EC:1.20.99.- should also be annotated to this term. synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with other acceptors" NARROW [] xref: EC:1.20 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0030614 name: oxidoreductase activity, acting on phosphorus or arsenic in donors, disulfide as acceptor namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction in which a phosphorus- or arsenic-containing group acts as a hydrogen or electron donor and reduces a disulfide." [GOC:mah] synonym: "oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulphide as acceptor" EXACT [] xref: EC:1.20.4 is_a: GO:0030613 ! oxidoreductase activity, acting on phosphorus or arsenic in donors [Term] id: GO:0030616 name: transforming growth factor beta receptor, common-partner cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that forms a complex with a phosphorylated pathway-specific mediator. The heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'common-partner SMAD protein ; GO:0005073' and is useful for annotating proteins of the SMAD family. synonym: "co-SMAD protein" RELATED [GOC:rl] synonym: "common mediator SMAD protein" RELATED [GOC:rl] synonym: "common partner SMAD protein" RELATED [GOC:rl] synonym: "common-mediator SMAD protein" RELATED [GOC:rl] synonym: "common-partner SMAD protein" RELATED [] synonym: "TGF-beta receptor, common-partner cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, common-partner cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030617 name: transforming growth factor beta receptor, inhibitory cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that inhibits the signaling function of common-partner and pathway-specific mediators." [PMID:9759503] comment: Note that this term can be used in place of the obsolete molecular function term 'inhibitory SMAD protein ; GO:0005074' and is useful for annotating proteins of the SMAD family. synonym: "inhibitory SMAD protein" RELATED [] synonym: "TGF-beta receptor, inhibitory cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, inhibitory cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030618 name: transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity namespace: molecular_function def: "A TGF-beta cytoplasmic mediator that is phosphorylated by a TGFbeta receptor and complexes with a common-partner mediator. The- heterocomplex translocates to the nucleus to regulate transcription." [GOC:hjd] comment: Note that this term can be used in place of the obsolete molecular function term 'pathway-specific SMAD protein ; GO:0005075' and is useful for annotating proteins of the SMAD family. synonym: "pathway restricted SMAD protein" RELATED [GOC:rl] synonym: "pathway-restricted SMAD protein" RELATED [GOC:rl] synonym: "pathway-specific SMAD protein" RELATED [] synonym: "receptor regulated SMAD protein" RELATED [GOC:rl] synonym: "receptor-regulated SMAD protein" RELATED [GOC:rl] synonym: "TGF-beta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, pathway-specific cytoplasmic mediator activity" EXACT [] is_a: GO:0005072 ! transforming growth factor beta receptor, cytoplasmic mediator activity [Term] id: GO:0030619 name: U1 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U1 small nuclear RNA (U1 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating other small nuclear RNAs (snRNAs). is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030620 name: U2 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U2 small nuclear RNA (U2 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030621 name: U4 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4 small nuclear RNA (U4 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030622 name: U4atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U4atac small nuclear RNA (U4atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030623 name: U5 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U5 small nuclear RNA (U5 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030624 name: U6atac snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U6atac small nuclear RNA (U6atac snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030625 name: U11 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U11 small nuclear RNA (U11 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030626 name: U12 snRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the U12 small nuclear RNA (U12 snRNA)." [GOC:jl] is_a: GO:0017069 ! snRNA binding [Term] id: GO:0030627 name: pre-mRNA 5'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 5' splice site sequence." [GOC:jl] synonym: "pre-mRNA 5' splice site binding" EXACT [] is_a: GO:0036002 ! pre-mRNA binding [Term] id: GO:0030628 name: pre-mRNA 3'-splice site binding namespace: molecular_function def: "Interacting selectively and non-covalently with the pre-mRNA 3' splice site sequence." [GOC:jl] synonym: "pre-mRNA 3' splice site binding" EXACT [] is_a: GO:0036002 ! pre-mRNA binding [Term] id: GO:0030629 name: U6 snRNA 3'-end binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' end of the U6 small nuclear RNA (U6 snRNA)." [GOC:mah] comment: Note that this term may be useful for annotating small nuclear RNAs (snRNAs). synonym: "U6 snRNA 3' end binding" EXACT [] is_a: GO:0017070 ! U6 snRNA binding [Term] id: GO:0030631 name: pyrrolysine incorporation namespace: biological_process def: "The incorporation of pyrrolysine, also known as lysine methylamine methyltransferase cofactor adduct, into a peptide; uses a special tRNA that recognizes the UAG codon as a modified lysine, rather than as a termination codon. Pyrrolysine may be synthesized as a free amino acid or synthesized from a lysine charged tRNA before its incorporation; it is not a posttranslational modification of peptidyl-lysine; this modification is found in several Methanosarcina methylamine methyltransferases." [PMID:11435424, PMID:17204561, RESID:AA0321] synonym: "lysine methylamine methyltransferase cofactor adduct incorporation" EXACT [RESID:AA0321] synonym: "monomethylamine methyltransferase cofactor lysine adduct incorporation" EXACT [CHEBI:21860] xref: RESID:AA0321 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0030632 name: D-alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of D-alanine, the D-enantiomer of the amino acid alanine, i.e (2R)-2-aminopropanoic acid." [CHEBI:15570, GOC:jsg, GOC:mah] synonym: "D-alanine anabolism" EXACT [] synonym: "D-alanine biosynthesis" EXACT [] synonym: "D-alanine formation" EXACT [] synonym: "D-alanine synthesis" EXACT [] is_a: GO:0046145 ! D-alanine family amino acid biosynthetic process is_a: GO:0046436 ! D-alanine metabolic process is_a: GO:0046437 ! D-amino acid biosynthetic process [Term] id: GO:0030633 name: D-alanine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of D-alanine and related amino acids." [GOC:mah] synonym: "D-alanine family amino acid breakdown" EXACT [] synonym: "D-alanine family amino acid catabolism" EXACT [] synonym: "D-alanine family amino acid degradation" EXACT [] is_a: GO:0006524 ! alanine catabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process [Term] id: GO:0030634 name: carbon fixation by acetyl-CoA pathway namespace: biological_process def: "A pathway of carbon dioxide fixation in which one molecule of acetyl-CoA is completely synthesized from two molecules of carbon dioxide (CO2)." [PMID:11607093] synonym: "Ljungdahl-Wood pathway" EXACT [] is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0015977 ! carbon fixation [Term] id: GO:0030635 name: obsolete acetate derivative metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving derivatives of acetic acid." [GOC:mah] comment: This term was made obsolete because it is an unnecessary grouping term, and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative metabolic process" EXACT [] synonym: "acetate derivative metabolism" EXACT [] is_obsolete: true consider: GO:1900619 [Term] id: GO:0030636 name: obsolete acetate derivative biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of derivatives of acetic acid." [GOC:mah] comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative anabolism" EXACT [] synonym: "acetate derivative biosynthesis" EXACT [] synonym: "acetate derivative biosynthetic process" EXACT [] synonym: "acetate derivative formation" EXACT [] synonym: "acetate derivative synthesis" EXACT [] is_obsolete: true consider: GO:1900620 [Term] id: GO:0030637 name: obsolete acetate derivative catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of derivatives of acetic acid." [GOC:ai] comment: This term was made obsolete because it is an unnecessary grouping term and has been replaced by terms to describe metabolism of specific compounds. synonym: "acetate derivative breakdown" EXACT [] synonym: "acetate derivative catabolic process" EXACT [] synonym: "acetate derivative catabolism" EXACT [] synonym: "acetate derivative degradation" EXACT [] is_obsolete: true [Term] id: GO:0030638 name: polyketide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0071704 ! organic substance metabolic process [Term] id: GO:0030639 name: polyketide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide anabolism" EXACT [] synonym: "polyketide biosynthesis" EXACT [] synonym: "polyketide formation" EXACT [] synonym: "polyketide synthesis" EXACT [] is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0044550 ! secondary metabolite biosynthetic process is_a: GO:1901576 ! organic substance biosynthetic process [Term] id: GO:0030640 name: polyketide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyketides, any of a diverse group of natural products synthesized via linear poly-beta-ketones, which are themselves formed by repetitive head-to-tail addition of acetyl (or substituted acetyl) units indirectly derived from acetate (or a substituted acetate) by a mechanism similar to that for fatty acid biosynthesis but without the intermediate reductive steps." [GOC:mah, ISBN:0198506732] synonym: "polyketide breakdown" EXACT [] synonym: "polyketide catabolism" EXACT [] synonym: "polyketide degradation" EXACT [] is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0090487 ! secondary metabolite catabolic process is_a: GO:1901575 ! organic substance catabolic process [Term] id: GO:0030641 name: regulation of cellular pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions (protons) within a cell or between a cell and its external environment." [GOC:dph, GOC:mah, GOC:tb] synonym: "cellular hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] synonym: "proton homeostasis" EXACT [] is_a: GO:0006885 ! regulation of pH is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis [Term] id: GO:0030642 name: cellular sulfate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of sulfate ions at the level of a cell." [GOC:mah] synonym: "sulphate ion homeostasis" BROAD [] is_a: GO:0055063 ! sulfate ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis [Term] id: GO:0030643 name: cellular phosphate ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of phosphate ions at the level of a cell." [GOC:mah] is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0055062 ! phosphate ion homeostasis is_a: GO:0072501 ! cellular divalent inorganic anion homeostasis is_a: GO:0072502 ! cellular trivalent inorganic anion homeostasis [Term] id: GO:0030644 name: cellular chloride ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of chloride ions at the level of a cell." [GOC:mah] is_a: GO:0030320 ! cellular monovalent inorganic anion homeostasis is_a: GO:0055064 ! chloride ion homeostasis [Term] id: GO:0030645 name: glucose catabolic process to butyrate namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of glucose, with the production of acetic acid, butyric acid, carbon dioxide (CO2), and dihydrogen; effected by some saccharolytic species of Clostridium, e.g. C. butyricum." [ISBN:0198506732] synonym: "butyrate fermentation" EXACT [] synonym: "glucose fermentation to butyrate" EXACT [] is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006113 ! fermentation is_a: GO:1902705 ! hexose catabolic process to butyrate [Term] id: GO:0030647 name: aminoglycoside antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic metabolism" EXACT [] is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030648 name: aminoglycoside antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic anabolism" EXACT [] synonym: "aminoglycoside antibiotic biosynthesis" EXACT [] synonym: "aminoglycoside antibiotic formation" EXACT [] synonym: "aminoglycoside antibiotic synthesis" EXACT [] is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030649 name: aminoglycoside antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of an aminoglycoside antibiotic, any member of a group of broad spectrum antibiotics, of similar toxicity and pharmacology, that contain an aminodeoxysugar, an amino- or guanidino-substituted inositol ring, and one or more residues of other sugars. The group includes streptomycin, neomycin, framycetin, kanamycin, paromomycin, and gentamicin." [GOC:mah, ISBN:0198506732] synonym: "aminoglycoside antibiotic breakdown" EXACT [] synonym: "aminoglycoside antibiotic catabolism" EXACT [] synonym: "aminoglycoside antibiotic degradation" EXACT [] is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030647 ! aminoglycoside antibiotic metabolic process [Term] id: GO:0030650 name: peptide antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0016999 ! antibiotic metabolic process [Term] id: GO:0030651 name: peptide antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic anabolism" EXACT [] synonym: "peptide antibiotic biosynthesis" EXACT [] synonym: "peptide antibiotic formation" EXACT [] synonym: "peptide antibiotic synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043043 ! peptide biosynthetic process [Term] id: GO:0030652 name: peptide antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of peptides with antibiotic activity." [GOC:mah] synonym: "peptide antibiotic breakdown" EXACT [] synonym: "peptide antibiotic catabolism" EXACT [] synonym: "peptide antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0030653 name: beta-lactam antibiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0044106 ! cellular amine metabolic process is_a: GO:0072338 ! cellular lactam metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0030654 name: beta-lactam antibiotic biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic anabolism" EXACT [] synonym: "beta-lactam antibiotic biosynthesis" EXACT [] synonym: "beta-lactam antibiotic formation" EXACT [] synonym: "beta-lactam antibiotic synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072339 ! cellular lactam biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0030655 name: beta-lactam antibiotic catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a beta-lactam antibiotic, any member of a class of natural or semisynthetic antibiotics whose characteristic feature is a strained, four-membered beta-lactam ring. They include the penicillins and many of the cephalosporins." [GOC:mah, ISBN:0198506732] synonym: "beta-lactam antibiotic breakdown" EXACT [] synonym: "beta-lactam antibiotic catabolism" EXACT [] synonym: "beta-lactam antibiotic degradation" EXACT [] is_a: GO:0017001 ! antibiotic catabolic process is_a: GO:0030653 ! beta-lactam antibiotic metabolic process is_a: GO:0072340 ! cellular lactam catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0030656 name: regulation of vitamin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:mah] synonym: "regulation of vitamin metabolism" EXACT [] is_a: GO:0062012 ! regulation of small molecule metabolic process relationship: regulates GO:0006766 ! vitamin metabolic process [Term] id: GO:0030657 name: obsolete regulation of coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. synonym: "regulation of coenzyme and prosthetic group metabolic process" EXACT [] is_obsolete: true consider: GO:0051196 consider: GO:0051199 [Term] id: GO:0030658 name: transport vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a transport vesicle." [GOC:mah] synonym: "constitutive secretory pathway transport vesicle membrane" EXACT [] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030133 ! transport vesicle [Term] id: GO:0030659 name: cytoplasmic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a cytoplasmic vesicle." [GOC:mah] is_a: GO:0012506 ! vesicle membrane is_a: GO:0044433 ! cytoplasmic vesicle part [Term] id: GO:0030660 name: Golgi-associated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a vesicle associated with the Golgi apparatus." [GOC:mah] synonym: "Golgi vesicle membrane" RELATED [] is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0005798 ! Golgi-associated vesicle [Term] id: GO:0030661 name: chitosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a chitosome." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0045009 ! chitosome [Term] id: GO:0030662 name: coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a coated vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030135 ! coated vesicle [Term] id: GO:0030663 name: COPI-coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a COPI-coated vesicle." [GOC:mah] synonym: "COPI coated vesicle membrane" EXACT [GOC:sl] is_a: GO:0030660 ! Golgi-associated vesicle membrane is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030137 ! COPI-coated vesicle [Term] id: GO:0030665 name: clathrin-coated vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated vesicle." [GOC:mah] synonym: "clathrin coated vesicle membrane" NARROW [GOC:sl] is_a: GO:0030662 ! coated vesicle membrane relationship: part_of GO:0030136 ! clathrin-coated vesicle [Term] id: GO:0030666 name: endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding an endocytic vesicle." [GOC:mah] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030139 ! endocytic vesicle [Term] id: GO:0030667 name: secretory granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a secretory granule." [GOC:mah] synonym: "secretory vesicle membrane" BROAD [] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0030141 ! secretory granule [Term] id: GO:0030668 name: merozoite dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense granule of the type found in apicomplexan parasites." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0020026 ! merozoite dense granule [Term] id: GO:0030669 name: clathrin-coated endocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated endocytic vesicle." [GOC:mah] is_a: GO:0030665 ! clathrin-coated vesicle membrane is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045334 ! clathrin-coated endocytic vesicle [Term] id: GO:0030670 name: phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a phagocytic vesicle." [GOC:mah] synonym: "phagosome membrane" EXACT [GOC:mah] is_a: GO:0030666 ! endocytic vesicle membrane relationship: part_of GO:0045335 ! phagocytic vesicle [Term] id: GO:0030671 name: clathrin-coated phagocytic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a clathrin-coated phagocytic vesicle." [GOC:mah] is_a: GO:0030669 ! clathrin-coated endocytic vesicle membrane is_a: GO:0030670 ! phagocytic vesicle membrane relationship: part_of GO:0045336 ! clathrin-coated phagocytic vesicle [Term] id: GO:0030672 name: synaptic vesicle membrane namespace: cellular_component def: "The lipid bilayer surrounding a synaptic vesicle." [GOC:mah] subset: goslim_synapse is_a: GO:0044456 ! synapse part is_a: GO:0097458 ! neuron part is_a: GO:0099501 ! exocytic vesicle membrane relationship: part_of GO:0008021 ! synaptic vesicle [Term] id: GO:0030673 name: axolemma namespace: cellular_component def: "The portion of the plasma membrane surrounding an axon; it is a specialized trilaminar random mosaic of protein molecules floating within a fluid matrix of highly mobile phospholipid molecules, 7-8 nm in thickness." [http://www.medik.sk/clanky/bio_jun.htm, ISBN:0124325653] synonym: "axonal membrane" EXACT [GOC:vk] xref: NIF_Subcellular:sao250772229 xref: Wikipedia:Axolemma is_a: GO:0032589 ! neuron projection membrane is_a: GO:0033267 ! axon part relationship: part_of GO:0044304 ! main axon [Term] id: GO:0030674 name: protein binding, bridging namespace: molecular_function def: "The binding activity of a molecule that brings together two or more protein molecules, or a protein and another macromolecule or complex, through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way." [GOC:bf, GOC:mah, GOC:vw] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "protein-protein adaptor" NARROW [] is_a: GO:0005515 ! protein binding is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0030676 name: Rac guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rac family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: reactome:R-HSA-399938 "Activation of Rac1 by FARP2" xref: reactome:R-HSA-428535 "Activation of RAC1 by SOS" xref: reactome:R-HSA-9032798 "DOCK3 activates RAC1" xref: reactome:R-HSA-9033292 "NTRK2 and CDK5 promote activation of RAC1 by TIAM1" xref: reactome:R-HSA-9619803 "p-S516-ARHGEF7 activates RAC1" is_a: GO:0005089 ! Rho guanyl-nucleotide exchange factor activity is_a: GO:0048365 ! Rac GTPase binding [Term] id: GO:0030677 name: ribonuclease P complex namespace: cellular_component def: "A ribonucleoprotein complex that catalyzes cleavage of the leader sequence of precursor tRNAs (pre-tRNAs), generating the mature 5' end of tRNAs." [GOC:mah, PMID:12045094] comment: Note that chloroplasts possess a complex that is called 'RNase P' because it catalyzes pre-tRNA cleavage, but the chloroplast complex appears not to contain RNA. subset: goslim_pir synonym: "RNase P complex" EXACT [] is_a: GO:1902555 ! endoribonuclease complex is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030678 name: mitochondrial ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the mitochondrion of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The subunit composition of mitochondrial ribonuclease P complexes varies between species, but the complex often contains a single RNA molecule and a single protein molecule." [GOC:mah, PMID:12045094] synonym: "mitochondrial RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex is_a: GO:0098798 ! mitochondrial protein complex [Term] id: GO:0030679 name: cyanelle ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the cyanelle, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. The best characterized cyanelle ribonuclease P complex, from the alga Cyanophora paradoxa, contains a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "cyanelle RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0030680 name: dimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that contains a single RNA molecule that is necessary and usually sufficient for catalysis, and a single protein molecule. Examples of this complex are found in Bacterial species." [GOC:mah, PMID:12045094] synonym: "dimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030681 name: multimeric ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex that generally contains a single RNA molecule and several protein molecules. Examples of this complex are found in Archaeal species." [GOC:mah, PMID:11142368, PMID:12045094] synonym: "multimeric RNase P complex" EXACT [] is_a: GO:0030677 ! ribonuclease P complex [Term] id: GO:0030682 name: evasion or tolerance of host defense response namespace: biological_process def: "Any process, either active or passive, by which an organism avoids or tolerates the effects of its host organism's defense response. The host defense response is mounted by the host in response to the presence of the organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mtg_pamgo_17jul06] synonym: "evasion of host defence response" EXACT [] is_a: GO:0044415 ! evasion or tolerance of host defenses is_a: GO:0051807 ! evasion or tolerance of defense response of other organism involved in symbiotic interaction [Term] id: GO:0030683 name: evasion or tolerance by virus of host immune response namespace: biological_process alt_id: GO:0019052 alt_id: GO:0019053 def: "Any process, either active or passive, by which a virus avoids the effects of the host organism's immune response. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:mah, GOC:pk] synonym: "evasion by virus of host immune response" NARROW [GOC:bf, GOC:bm, GOC:jl] synonym: "inhibition of extracellular antiviral response" EXACT [] synonym: "negative regulation by virus of extracellular antiviral response" EXACT [] synonym: "negative regulation by virus of intracellular antiviral response" EXACT [] synonym: "negative regulation of host extracellular antiviral response by virus" EXACT [] synonym: "negative regulation of host intracellular antiviral response by virus" EXACT [] synonym: "suppression by virus of host extracellular antiviral response" EXACT [] synonym: "suppression by virus of host immune response" NARROW [GOC:bf] synonym: "suppression by virus of host intracellular antiviral response" EXACT [] synonym: "suppression of host extracellular antiviral response by virus" EXACT [] synonym: "suppression of host intracellular antiviral response by virus" EXACT [] synonym: "viral inhibition of intracellular antiviral response" EXACT [] is_a: GO:0019049 ! evasion or tolerance of host defenses by virus is_a: GO:0020012 ! evasion or tolerance of host immune response is_a: GO:0050690 ! regulation of defense response to virus by virus [Term] id: GO:0030684 name: preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed during ribosome biogenesis." [PMID:10567516] subset: goslim_pir is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0030685 name: nucleolar preribosome namespace: cellular_component def: "Any complex of pre-rRNAs, ribosomal proteins, and associated proteins formed in the nucleolus during ribosome biogenesis." [PMID:10567516] is_a: GO:0030684 ! preribosome is_a: GO:0044452 ! nucleolar part [Term] id: GO:0030686 name: 90S preribosome namespace: cellular_component def: "A large ribonucleoprotein complex considered to be the earliest preribosomal complex. In S. cerevisiae, it has a size of 90S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12150911, PMID:12957375, PMID:15120992] is_a: GO:0030684 ! preribosome [Term] id: GO:0030687 name: preribosome, large subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 27SA, 27SB, and/or 7S pre-rRNA, 5S rRNA, ribosomal proteins including late-associating large subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic large ribosomal subunit." [PMID:10567516] comment: Note that this complex is 66S in Saccharomyces. synonym: "66S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030688 name: preribosome, small subunit precursor namespace: cellular_component def: "A preribosomal complex consisting of 20S pre-rRNA, ribosomal proteins including late-associating small subunit proteins, and associated proteins; a precursor of the eukaryotic cytoplasmic small ribosomal subunit." [PMID:10567516] comment: Note that this complex is 43S in Saccharomyces. synonym: "43S preribosome" NARROW [] is_a: GO:0030684 ! preribosome [Term] id: GO:0030689 name: Noc complex namespace: cellular_component def: "Any of several heterodimers containing one or two Noc proteins, associated with preribosomal complexes; involved in ribosome biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the definition uses Saccharomyces gene product names because this complex has only been described in Saccharomyces cerevisiae and no other names have yet arisen; the term nevertheless can be used for analogous complexes in other eukaryotes, and the definition can be changed if better wording is found. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030690 name: Noc1p-Noc2p complex namespace: cellular_component def: "A heterodimer associated with 90S and 66S preribosomes. Predominantly, but not exclusively, nucleolar; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030691 name: Noc2p-Noc3p complex namespace: cellular_component def: "A heterodimer associated with 66S preribosomes; predominantly nucleoplasmic, but also locates to the nucleolus; involved in ribosomal large subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030687 ! preribosome, large subunit precursor [Term] id: GO:0030692 name: Noc4p-Nop14p complex namespace: cellular_component def: "A heterodimer associated with precursors of the eukaryotic small ribosomal subunit, including the 90S preribosome; involved in small subunit biogenesis." [PMID:12446671] comment: Noc complexes exhibit a dynamic intranuclear location; consider also annotating to 'nucleolus ; GO:0005730' and/or 'nucleoplasm ; GO:0005654' and/or 'nuclear pore ; GO:0005643'. Note that the term name uses Saccharomyces gene product names because no other names have yet arisen for this complex; the term nevertheless can be used for analogous complexes in other eukaryotes, and the name can be changed if better wording is found. synonym: "Nop7 complex" EXACT [GOC:jh, GOC:mah] synonym: "Nop7 subcomplex" EXACT [GOC:jh, GOC:mah, PMID:18448671] is_a: GO:0030689 ! Noc complex relationship: part_of GO:0030686 ! 90S preribosome relationship: part_of GO:0030688 ! preribosome, small subunit precursor [Term] id: GO:0030693 name: obsolete caspase activity namespace: molecular_function alt_id: GO:0004199 def: "OBSOLETE. Catalysis of the hydrolysis of a peptide bond on the carboxyl side of an aspartate residue." [PMID:10872455] comment: This term was made obsolete because it represents a gene product. synonym: "caspase activity" EXACT [] synonym: "caspase-1 activity" NARROW [] synonym: "caspase-10 activity" NARROW [] synonym: "caspase-2 activity" NARROW [] synonym: "caspase-3 activity" NARROW [] synonym: "caspase-4 activity" NARROW [] synonym: "caspase-5 activity" NARROW [] synonym: "caspase-6 activity" NARROW [] synonym: "caspase-7 activity" NARROW [] synonym: "caspase-8 activity" NARROW [] synonym: "caspase-9 activity" NARROW [] synonym: "effector caspase activity" NARROW [] synonym: "signaling (initiator) caspase activity" NARROW [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0030694 name: bacterial-type flagellum basal body, rod namespace: cellular_component def: "The central portion of the bacterial-type flagellar basal body, which spans the periplasm and threads through the rings." [GOC:cilia, GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] synonym: "flagellar basal body, rod" EXACT [] synonym: "flagellin-based flagellum basal body, rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0030695 name: GTPase regulator activity namespace: molecular_function alt_id: GO:0005083 def: "Modulates the rate of GTP hydrolysis by a GTPase." [GOC:mah] synonym: "small GTPase regulator activity" RELATED [] synonym: "small GTPase regulatory/interacting protein activity" RELATED [] is_a: GO:0060589 ! nucleoside-triphosphatase regulator activity [Term] id: GO:0030696 name: tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to the C5 atom of the uridine residue at position 54 in a tRNA molecule." [ISBN:1555811337] comment: Note that the term name mentions a specific position within a tRNA because no other names have yet arisen for this activity, and because the position is conserved in nearly all tRNAs. The term nevertheless can be used for activities that methylase an analogous residue at a position other than 54, if such is found, and synonyms that mention positions applicable to other tRNAs or species may also be added. synonym: "RUMT" EXACT [] is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0030697 name: S-adenosylmethionine-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function alt_id: GO:0009021 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine at position U54 of a transfer RNA. This occurs in most Gram-negative bacteria, some archae, and eukaryotes." [GOC:hjd, ISBN:1555811337] synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] synonym: "RUMT" BROAD [] synonym: "RUMT activity" EXACT [EC:2.1.1.35] synonym: "S-adenosyl methionine-dependent tRNA (m5U54) methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] synonym: "tRNA (uracil-5-)-methyltransferase activity" EXACT [] synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity [Term] id: GO:0030698 name: 5,10-methylenetetrahydrofolate-dependent tRNA (m5U54) methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from 5,10-methylenetetrahydrofolate to the C5 atom of the uridine residue at position 54 in a tRNA molecule. This occurs in most Gram-positive bacteria and some Gram-negative bacteria." [GOC:hjd, ISBN:1555811337] synonym: "RUMT" BROAD [] is_a: GO:0030696 ! tRNA (m5U54) methyltransferase activity is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0030699 name: glycine reductase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + H(2)O + NH(4)(+) + thioredoxin disulfide = glycine + H(+) + phosphate + thioredoxin." [EC:1.21.4.2, RHEA:12232] synonym: "acetyl-phosphate ammonia:thioredoxin disulfide oxidoreductase (glycine-forming)" EXACT [EC:1.21.4.2] xref: EC:1.21.4.2 xref: KEGG:R07226 xref: MetaCyc:RXN-7566 xref: RHEA:12232 is_a: GO:0050485 ! oxidoreductase activity, acting on X-H and Y-H to form an X-Y bond, with a disulfide as acceptor [Term] id: GO:0030700 name: glycine reductase complex namespace: cellular_component def: "Complex that possesses glycine reductase activity; usually comprises three subunits, of which two are selenoproteins; the subunits are typically designated selenoprotein A, selenoprotein B and protein C." [GOC:mah, PMID:2018775] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glycine reductase activity ; GO:0030699'. is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0030701 name: NAD+-dinitrogen-reductase ADP-D-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + [dinitrogen reductase] = nicotinamide + ADP-D-ribosyl-[dinitrogen reductase]." [EC:2.4.2.37] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.37] synonym: "NAD+:[dinitrogen reductase] (ADP-D-ribosyl)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD--azoferredoxin (ADP-ribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-azoferredoxin (ADPribose)transferase activity" EXACT [EC:2.4.2.37] synonym: "NAD-dinitrogen-reductase ADP-D-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.37 xref: MetaCyc:2.4.2.37-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0030702 name: chromatin silencing at centromere namespace: biological_process def: "Repression of transcription of centromeric DNA by altering the structure of chromatin." [GOC:mah] synonym: "centromere chromatin silencing" EXACT [GOC:mah] synonym: "centromeric silencing" EXACT [GOC:vw] synonym: "heterochromatic silencing at centromere" EXACT [] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0030703 name: eggshell formation namespace: biological_process def: "Construction of the eggshell, a product of the somatic follicle cell epithelium and a structure that supports the egg in a hostile environment, minimizing water loss whilst allowing gas exchanges essential for embryonic respiration." [GOC:mtg_sensu, ISBN:0879694238, PMID:10822261] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030704 name: vitelline membrane formation namespace: biological_process def: "Construction of the vitelline membrane portion of the egg shell, a rigid structure required to maintain the shape of the egg." [ISBN:0879694238] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0035803 ! egg coat formation is_a: GO:0085029 ! extracellular matrix assembly [Term] id: GO:0030705 name: cytoskeleton-dependent intracellular transport namespace: biological_process def: "The directed movement of substances along cytoskeletal fibers such as microfilaments or microtubules within a cell." [GOC:mah] subset: goslim_chembl subset: goslim_generic is_a: GO:0046907 ! intracellular transport [Term] id: GO:0030706 name: germarium-derived oocyte differentiation namespace: biological_process def: "The process in which one relatively unspecialized immature cystocyte of the germ-line cyst in the germarium acquires the specialized features of an oocyte. An example of this process can be found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte cell differentiation" RELATED [] is_a: GO:0009994 ! oocyte differentiation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030707 name: ovarian follicle cell development namespace: biological_process def: "The process that occurs during oogenesis involving the ovarian follicle cells, somatic cells which surround the germ cells of an ovary. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030708 name: germarium-derived female germ-line cyst encapsulation namespace: biological_process def: "Formation of a single follicular epithelium around the germ-line derived cells of a cyst formed in the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11591336] is_a: GO:0048139 ! female germ-line cyst encapsulation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030709 name: border follicle cell delamination namespace: biological_process def: "The delamination process that results in the splitting off of border cells from the anterior epithelium, prior to border cell migration." [PMID:10822261] synonym: "border cell delamination" BROAD [] is_a: GO:0022414 ! reproductive process is_a: GO:0060232 ! delamination relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030710 name: regulation of border follicle cell delamination namespace: biological_process def: "Any process that regulates the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "regulation of border cell delamination" BROAD [] is_a: GO:0022407 ! regulation of cell-cell adhesion is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905879 ! regulation of oogenesis relationship: regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030711 name: positive regulation of border follicle cell delamination namespace: biological_process def: "Any process that increases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "activation of border follicle cell delamination" NARROW [] synonym: "positive regulation of border cell delamination" BROAD [] synonym: "stimulation of border follicle cell delamination" NARROW [] synonym: "up regulation of border follicle cell delamination" EXACT [] synonym: "up-regulation of border follicle cell delamination" EXACT [] synonym: "upregulation of border follicle cell delamination" EXACT [] is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:1905881 ! positive regulation of oogenesis relationship: positively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030712 name: negative regulation of border follicle cell delamination namespace: biological_process def: "Any process that decreases the frequency, rate or extent of border cell delamination." [PMID:10822261] synonym: "down regulation of border follicle cell delamination" EXACT [] synonym: "down-regulation of border follicle cell delamination" EXACT [] synonym: "downregulation of border follicle cell delamination" EXACT [] synonym: "inhibition of border follicle cell delamination" NARROW [] synonym: "negative regulation of border cell delamination" BROAD [] is_a: GO:0022409 ! positive regulation of cell-cell adhesion is_a: GO:0030710 ! regulation of border follicle cell delamination is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:1905880 ! negative regulation of oogenesis relationship: negatively_regulates GO:0030709 ! border follicle cell delamination [Term] id: GO:0030713 name: ovarian follicle cell stalk formation namespace: biological_process def: "Development of ovarian follicle cells to create the interfollicular stalks that connect the egg chambers of progressive developmental stages. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030714 name: anterior/posterior axis specification, follicular epithelium namespace: biological_process def: "Polarization of the follicle cells of an insect ovary along the anterior/posterior axis." [GOC:bf] synonym: "anterior/posterior axis determination, follicular epithelium" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0009798 ! axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0030715 name: oocyte growth in germarium-derived egg chamber namespace: biological_process def: "The increase in volume of an oocyte during the growth phase of the egg chamber, once the egg chamber has left the germarium. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0001555 ! oocyte growth relationship: part_of GO:0007295 ! growth of a germarium-derived egg chamber [Term] id: GO:0030716 name: oocyte fate determination namespace: biological_process def: "The process in which a cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] synonym: "oocyte cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination [Term] id: GO:0030717 name: oocyte karyosome formation namespace: biological_process def: "The chromosome organization process in which meiotic chromosomes in the oocyte nucleus cluster together to form a compact spherical structure called the karyosome." [PMID:11700288, PMID:18039935] is_a: GO:0061988 ! karyosome formation relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0030718 name: germ-line stem cell population maintenance namespace: biological_process def: "Any process by which an organism or tissue maintains a population of germ-line stem cells." [ISBN:0879694238] is_a: GO:0019827 ! stem cell population maintenance [Term] id: GO:0030719 name: P granule organization namespace: biological_process alt_id: GO:0048114 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of polar granules, cytoplasmic, non-membranous RNA/protein complex aggregates in the primordial germ cells of many higher eukaryotes." [PMID:10851135, PMID:770367] synonym: "P granule organization and biogenesis" RELATED [] synonym: "polar granule organisation" EXACT [GOC:curators] synonym: "polar granule organization and biogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0006996 ! organelle organization is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0071826 ! ribonucleoprotein complex subunit organization relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0030720 name: oocyte localization involved in germarium-derived egg chamber formation namespace: biological_process def: "Directed movement of the oocyte, following its specification, from its original central position in the cyst to a posterior position relative to the nurse cells of the egg chamber, and its maintenance in this posterior location. This is the first sign of anterior-posterior asymmetry in the developing egg chamber." [GOC:mtg_sensu, PMID:10449356] synonym: "establishment and maintenance of oocyte localization in egg chamber" EXACT [] synonym: "establishment and maintenance of oocyte position during oogenesis" EXACT [] synonym: "oocyte localisation involved in germarium-derived egg chamber formation" EXACT [GOC:mah] synonym: "oocyte localization during germarium-derived egg chamber formation" RELATED [GOC:dph, GOC:tb] synonym: "oocyte localization during oogenesis" RELATED [] synonym: "oocyte positioning during oogenesis" NARROW [] synonym: "oogenesis, establishment and maintenance of oocyte localization" EXACT [] synonym: "oogenesis, oocyte localization" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0051674 ! localization of cell relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030721 name: spectrosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spectrosome, a germline specific spherical organelle that is the precursor to the fusome." [PMID:11131529] synonym: "spectrosome organisation" EXACT [GOC:curators] synonym: "spectrosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0030723 name: ovarian fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of ovarian cells, an organelle derived from the spectrosome. It anchors the mitotic spindle pole to provide orientation during cystoblast cell divisions." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "ovarian fusome organisation" EXACT [GOC:curators] synonym: "ovarian fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030724 name: testicular fusome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fusome of testicular cells, an organelle derived from the spectrosome." [GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "testicular fusome organisation" EXACT [GOC:curators] synonym: "testicular fusome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045478 ! fusome organization relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030725 name: germline ring canal formation namespace: biological_process def: "Assembly of the cytoplasmic bridges between developing spermatogonial or oogonial cysts." [ISBN:0879694238] synonym: "ring canal formation" BROAD [] is_a: GO:0022412 ! cellular process involved in reproduction in multicellular organism is_a: GO:0043063 ! intercellular bridge organization [Term] id: GO:0030726 name: male germline ring canal formation namespace: biological_process def: "Formation of the intercellular bridges that connect the germ-line cells of a male cyst." [ISBN:0879694238] synonym: "spermatocyte ring canal formation" NARROW [] synonym: "testicular ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0030727 name: germarium-derived female germ-line cyst formation namespace: biological_process def: "Formation, in a germarium, of a group of interconnected cells derived from a single female gonial founder cell (a cystoblast). The germarium is the most anterior portion of an insect ovariole. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10370240, PMID:9442902] synonym: "germarium-derived female germline cyst formation" EXACT [] is_a: GO:0048135 ! female germ-line cyst formation relationship: part_of GO:0007293 ! germarium-derived egg chamber formation [Term] id: GO:0030728 name: ovulation namespace: biological_process def: "The release of a mature ovum/oocyte from an ovary." [GOC:bf, ISBN:0878932437] xref: Wikipedia:Ovulation is_a: GO:0048609 ! multicellular organismal reproductive process relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0030729 name: acetoacetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: acetoacetate + ATP + CoA = acetoacetyl-CoA + AMP + diphosphate + H(+)." [EC:6.2.1.16, RHEA:16117] synonym: "acetoacetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.16] synonym: "acetoacetyl-CoA synthetase activity" EXACT [] xref: EC:6.2.1.16 xref: KEGG:R01357 xref: MetaCyc:ACETOACETATE--COA-LIGASE-RXN xref: reactome:R-HSA-5694494 "AACS ligates CoA-SH to ACA, forming ACA-CoA" xref: RHEA:16117 is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0030730 name: sequestering of triglyceride namespace: biological_process def: "The process of binding or confining any triester of glycerol such that it is separated from other components of a biological system." [GOC:mah, ISBN:0198506732] synonym: "retention of triacylglycerol" EXACT [] synonym: "retention of triglyceride" EXACT [] synonym: "sequestering of triacylglycerol" EXACT [] synonym: "sequestration of triacylglycerol" EXACT [] synonym: "sequestration of triglyceride" EXACT [] synonym: "storage of triacylglycerol" EXACT [] synonym: "storage of triglyceride" EXACT [] synonym: "triacylglycerol retention" EXACT [] synonym: "triacylglycerol sequestering" EXACT [] synonym: "triacylglycerol sequestration" EXACT [] synonym: "triacylglycerol storage" EXACT [] synonym: "triglyceride retention" EXACT [] synonym: "triglyceride sequestering" EXACT [] synonym: "triglyceride sequestration" EXACT [] synonym: "triglyceride storage" EXACT [] is_a: GO:0019915 ! lipid storage [Term] id: GO:0030731 name: guanidinoacetate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + guanidinoacetate = S-adenosyl-L-homocysteine + creatine + H(+)." [EC:2.1.1.2, RHEA:10656] synonym: "GA methylpherase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "guanidinoacetate transmethylase activity" EXACT [EC:2.1.1.2] synonym: "guanidoacetate methyltransferase activity" EXACT [EC:2.1.1.2] synonym: "methionine-guanidinoacetic transmethylase activity" EXACT [EC:2.1.1.2] synonym: "S-adenosyl-L-methionine:N-guanidinoacetate methyltransferase activity" EXACT [EC:2.1.1.2] xref: EC:2.1.1.2 xref: KEGG:R01883 xref: MetaCyc:GUANIDINOACETATE-N-METHYLTRANSFERASE-RXN xref: RHEA:10656 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030732 name: methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-methionine = S-adenosyl-L-homocysteine + S-methyl-L-methionine." [EC:2.1.1.12] synonym: "methionine methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl methionine:methionine methyl transferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosyl-L-methionine:L-methionine S-methyltransferase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.12] synonym: "S-adenosylmethionine-methionine methyltransferase activity" EXACT [EC:2.1.1.12] xref: EC:2.1.1.12 xref: MetaCyc:METHIONINE-S-METHYLTRANSFERASE-RXN xref: RHEA:13761 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030733 name: fatty acid O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a fatty acid = S-adenosyl-L-homocysteine + a fatty acid methyl ester." [EC:2.1.1.15] synonym: "fatty acid methyltransferase activity" EXACT [EC:2.1.1.15] synonym: "fatty-acid O-methyltransferase activity" EXACT [] synonym: "S-adenosyl-L-methionine:fatty-acid O-methyltransferase activity" EXACT [EC:2.1.1.15] xref: EC:2.1.1.15 xref: MetaCyc:FATTY-ACID-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030734 name: polysaccharide O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 1,4-N1-D-glucooligosaccharide = S-adenosyl-L-homocysteine + oligosaccharide containing 6-methyl-D-glucose units." [EC:2.1.1.18] synonym: "acylpolysacharide 6-methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "polysaccharide methyltransferase activity" EXACT [EC:2.1.1.18] synonym: "S-adenosyl-L-methionine:1,4-alpha-D-glucan 6-O-methyltransferase activity" EXACT [EC:2.1.1.18] xref: EC:2.1.1.18 xref: MetaCyc:POLYSACCHARIDE-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030735 name: carnosine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + carnosine = S-adenosyl-L-homocysteine + anserine + H(+)." [EC:2.1.1.22, RHEA:14205] synonym: "S-adenosyl-L-methionine:carnosine N-methyltransferase activity" EXACT [EC:2.1.1.22] xref: EC:2.1.1.22 xref: KEGG:R02144 xref: MetaCyc:CARNOSINE-N-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-8876789 "CARNMT1 methylates CARN to Anserine" xref: RHEA:14205 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030736 name: phenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenol = S-adenosyl-L-homocysteine + anisole + H(+)." [EC:2.1.1.25, RHEA:14809] synonym: "PMT" RELATED [EC:2.1.1.25] synonym: "S-adenosyl-L-methionine:phenol O-methyltransferase activity" EXACT [EC:2.1.1.25] xref: EC:2.1.1.25 xref: KEGG:R01239 xref: MetaCyc:PHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14809 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030737 name: iodophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-iodophenol + S-adenosyl-L-methionine = 1-iodo-2-methoxybenzene + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.26, RHEA:14313] synonym: "S-adenosyl-L-methionine:2-iodophenol O-methyltransferase activity" EXACT [EC:2.1.1.26] xref: EC:2.1.1.26 xref: KEGG:R03746 xref: MetaCyc:IODOPHENOL-O-METHYLTRANSFERASE-RXN xref: RHEA:14313 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030738 name: tyramine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tyramine = N-methyltyramine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.27, RHEA:14865] synonym: "DIB O-methyltransferase (3,5-diiodo-4-hydroxy-benzoic acid)" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-L-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "S-adenosyl-methionine:tyramine N-methyltransferase activity" EXACT [EC:2.1.1.27] synonym: "tyramine methylpherase activity" EXACT [EC:2.1.1.27] xref: EC:2.1.1.27 xref: KEGG:R02384 xref: MetaCyc:TYRAMINE-N-METHYLTRANSFERASE-RXN xref: RHEA:14865 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030739 name: O-demethylpuromycin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + O-demethylpuromycin = S-adenosyl-L-homocysteine + puromycin." [EC:2.1.1.38] synonym: "O-demethylpuromycin methyltransferase activity" EXACT [EC:2.1.1.38] synonym: "S-adenosyl-L-methionine:O-demethylpuromycin O-methyltransferase activity" EXACT [EC:2.1.1.38] xref: EC:2.1.1.38 xref: MetaCyc:2.1.1.38-RXN xref: RHEA:22280 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030740 name: inositol 3-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-3-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.39, RHEA:18877] synonym: "inositol L-1-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.39] synonym: "myo-inositol 1-O-methyltransferase activity" RELATED [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosyl-L-methionine:myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.39] synonym: "S-adenosylmethionine:myo-inositol 1-methyltransferase activity" EXACT [EC:2.1.1.39] xref: EC:2.1.1.39 xref: KEGG:R01189 xref: MetaCyc:MYO-INOSITOL-1-O-METHYLTRANSFERASE-RXN xref: RHEA:18877 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030741 name: inositol 1-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-1-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.40, RHEA:17565] synonym: "inositol 3-O-methyltransferase (name based on 1L-numbering system and not 1D-numbering)" EXACT [EC:2.1.1.40] synonym: "inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "inositol D-1-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "myo-inositol 3-O-methyltransferase activity" RELATED [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 1-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosyl-L-methionine:myo-inositol 3-O-methyltransferase activity" EXACT [EC:2.1.1.40] synonym: "S-adenosylmethionine:myo-inositol 3-methyltransferase activity" RELATED [EC:2.1.1.40] xref: EC:2.1.1.40 xref: KEGG:R01188 xref: MetaCyc:MYO-INOSITOL-3-O-METHYLTRANSFERASE-RXN xref: RHEA:17565 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030742 name: GTP-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules) when at least one of the interacting partners is in the GTP-bound state." [GOC:go_curators, GOC:krc] comment: This term may be used to annotate both partners in a GTP-dependent binding interaction, both the GTP-bound protein and the protein(s) which interact with it. is_a: GO:0005515 ! protein binding [Term] id: GO:0030743 name: rRNA (adenosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing a single residue of 2'-O-methyladenosine." [EC:2.1.1.66] synonym: "ribosomal ribonucleate adenosine 2'-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "RNA-pentose methylase activity" RELATED [EC:2.1.1.66] synonym: "rRNA adenosine 2'-methylase activity" EXACT [EC:2.1.1.66] synonym: "S-adenosyl-L-methionine:rRNA (adenosine-2'-O)-methyltransferase activity" EXACT [EC:2.1.1.66] synonym: "thiostrepton-resistance methylase activity" NARROW [EC:2.1.1.66] xref: EC:2.1.1.66 xref: MetaCyc:2.1.1.66-RXN is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity is_a: GO:0062105 ! RNA 2'-O-methyltransferase activity [Term] id: GO:0030744 name: luteolin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + luteolin = 4',5,7-trihydroxy-3'-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.42, RHEA:14589] synonym: "luteolin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "luteolin methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol meta-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-dihydric phenol methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "o-diphenol m-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxyflavone 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] synonym: "S-adenosylmethionine:flavone/flavonol 3'-O-methyltransferase activity" EXACT [EC:2.1.1.42] xref: EC:2.1.1.42 xref: KEGG:R03587 xref: MetaCyc:LUTEOLIN-O-METHYLTRANSFERASE-RXN xref: RHEA:14589 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030745 name: dimethylhistidine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + N-alpha,N-alpha-dimethyl-L-histidine = S-adenosyl-L-homocysteine + N-alpha,N-alpha,N-alpha-trimethyl-L-histidine." [EC:2.1.1.44] synonym: "dimethylhistidine methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "histidine-alpha-N-methyltransferase activity" BROAD [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:alpha-N,alpha-N-dimethyl-L-histidine alpha-N-methyltransferase activity" EXACT [EC:2.1.1.44] synonym: "S-adenosyl-L-methionine:Nalpha,Nalpha-dimethyl-L-histidine nalpha-methyltransferase activity" EXACT [EC:2.1.1.44] xref: EC:2.1.1.44 xref: KEGG:R04436 xref: MetaCyc:2.1.1.44-RXN xref: RHEA:11104 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030746 name: isoflavone 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + isoflavone = S-adenosyl-L-homocysteine + 4'-O-methylisoflavone." [EC:2.1.1.46] synonym: "4'-hydroxyisoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "isoflavone O-methyltransferase activity" EXACT [EC:2.1.1.46] synonym: "S-adenosyl-L-methionine:isoflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.46] xref: EC:2.1.1.46 xref: MetaCyc:ISOFLAVONE-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030747 name: indolepyruvate C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (indol-3-yl)pyruvate = S-adenosyl-L-homocysteine + (S)-3-(indol-3-yl)-2-oxobutanoate." [EC:2.1.1.47] synonym: "indolepyruvate 3-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvate methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "indolepyruvic acid methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:(indol-3-yl)pyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] synonym: "S-adenosyl-L-methionine:indolepyruvate C-methyltransferase activity" EXACT [EC:2.1.1.47] xref: EC:2.1.1.47 xref: MetaCyc:INDOLEPYRUVATE-C-METHYLTRANSFERASE-RXN xref: RHEA:12112 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030748 name: amine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + an amine = S-adenosyl-L-homocysteine + a methylated amine." [EC:2.1.1.49] synonym: "arylamine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "nicotine N-methyltransferase activity" NARROW [EC:2.1.1.49] synonym: "S-adenosyl-L-methionine:amine N-methyltransferase activity" EXACT [EC:2.1.1.49] synonym: "tryptamine methyltransferase" NARROW [EC:2.1.1.49] synonym: "tryptamine N-methyltransferase activity" NARROW [EC:2.1.1.49] xref: EC:2.1.1.49 xref: MetaCyc:AMINE-N-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030749 name: loganate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + loganate = S-adenosyl-L-homocysteine + loganin." [EC:2.1.1.50] synonym: "loganate methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganate 11-O-methyltransferase activity" EXACT [EC:2.1.1.50] synonym: "S-adenosyl-L-methionine:loganic acid methyltransferase activity" EXACT [EC:2.1.1.50] xref: EC:2.1.1.50 xref: MetaCyc:LOGANATE-O-METHYLTRANSFERASE-RXN xref: RHEA:12508 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030750 name: putrescine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + putrescine = N-methylputrescine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.53, RHEA:15037] synonym: "putrescine methyltransferase activity" EXACT [EC:2.1.1.53] synonym: "S-adenosyl-L-methionine:putrescine N-methyltransferase activity" EXACT [EC:2.1.1.53] xref: EC:2.1.1.53 xref: KEGG:R01153 xref: MetaCyc:PUTRESCINE-N-METHYLTRANSFERASE-RXN xref: RHEA:15037 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030751 name: licodione 2'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + licodione = 2'-O-methyllicodione + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.65, RHEA:18521] synonym: "S-adenosyl-L-methionine:licodione 2'-O-methyltransferase activity" EXACT [EC:2.1.1.65] xref: EC:2.1.1.65 xref: KEGG:R03623 xref: MetaCyc:LICODIONE-2-O-METHYLTRANSFERASE-RXN xref: RHEA:18521 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030752 name: 5-hydroxyfuranocoumarin 5-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030764 def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-hydroxyfuranocoumarin = S-adenosyl-L-homocysteine + 5-methoxyfuranocoumarin." [EC:2.1.1.69] synonym: "bergaptol 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "BMT activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "furanocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfuranocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:5-hydroxyfurocoumarin 5-O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptol O-methyltransferase activity" EXACT [EC:2.1.1.69] synonym: "S-adenosyl-L-methionine:bergaptolO-methyltransferase activity" EXACT [EC:2.1.1.69] xref: EC:2.1.1.69 xref: MetaCyc:2.1.1.69-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030753 name: 8-hydroxyfuranocoumarin 8-O-methyltransferase activity namespace: molecular_function alt_id: GO:0030765 def: "Catalysis of the reaction: S-adenosyl-L-methionine + xanthotoxol = S-adenosyl-L-homocysteine + xanthotoxin. Xanthotoxol is also known as 8-hydroxyfuranocoumarin and xanthotoxin as 8-methoxyfuranocoumarin." [EC:2.1.1.70] synonym: "furanocoumarin 8-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "furanocoumarin 8-O-methyl-transferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfuranocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:8-hydroxyfurocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "S-adenosyl-L-methionine:xanthotoxol O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol 8-O-methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol methyltransferase activity" EXACT [EC:2.1.1.70] synonym: "xanthotoxol O-methyltransferase activity" EXACT [] synonym: "XMT activity" RELATED [EC:2.1.1.70] xref: EC:2.1.1.70 xref: KEGG:R02982 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030754 name: apigenin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5,7,4'-trihydroxyflavone = S-adenosyl-L-homocysteine + 4'-methoxy-5,7-dihydroxyflavone." [EC:2.1.1.75] synonym: "flavonoid methyltransferase activity" EXACT [EC:2.1.1.75] synonym: "flavonoid O-methyltransferase activity" BROAD [EC:2.1.1.75] synonym: "S-adenosyl-L-methionine:5,7,4'-trihydroxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.75] xref: EC:2.1.1.75 xref: MetaCyc:APIGENIN-4-O-METHYLTRANSFERASE-RXN xref: RHEA:20429 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030755 name: quercetin 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3,5,7,3',4'-pentahydroxyflavone = S-adenosyl-L-homocysteine + 3-methoxy-5,7,3',4'-tetrahydroxy-flavone." [EC:2.1.1.76] synonym: "flavonoid 3-methyltransferase activity" EXACT [EC:2.1.1.76] synonym: "flavonol 3-O-methyltransferase activity" RELATED [EC:2.1.1.76] synonym: "S-adenosyl-L-methionine:3,5,7,3',4'-pentahydroxyflavone 3-O-methyltransferase activity" EXACT [EC:2.1.1.76] xref: EC:2.1.1.76 xref: MetaCyc:QUERCETIN-3-O-METHYLTRANSFERASE-RXN xref: RHEA:17673 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030756 name: isoorientin 3'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + isoorientin = S-adenosyl-L-homocysteine + H(+) + isoscoparin." [EC:2.1.1.78, RHEA:24096] synonym: "isoorientin 3'-methyltransferase activity" EXACT [EC:2.1.1.78] synonym: "S-adenosyl-L-methionine:isoorientin 3'-O-methyltransferase activity" EXACT [EC:2.1.1.78] xref: EC:2.1.1.78 xref: KEGG:R03731 xref: MetaCyc:ISOORIENTIN-3-O-METHYLTRANSFERASE-RXN xref: RHEA:24096 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030757 name: 3-methylquercitin 7-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,7-tetrahydroxy-3-methoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-homocysteine." [EC:2.1.1.82, RHEA:16181] synonym: "3-methylquercetin 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "7-OMT activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "flavonol 7-O-methyltransferase activity" RELATED [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:3',4',5,7-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] synonym: "S-adenosyl-L-methionine:5,7,3',4'-tetrahydroxy-3-methoxyflavone 7-O-methyltransferase activity" EXACT [EC:2.1.1.82] xref: EC:2.1.1.82 xref: KEGG:R05323 xref: MetaCyc:2.1.1.82-RXN xref: RHEA:16181 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030758 name: 3,7-dimethylquercitin 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5-trihydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',5-dihydroxy-3,4',7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.83, RHEA:21832] synonym: "3,7-dimethylquercetin 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "4'-OMT activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "flavonol 4'-O-methyltransferase activity" RELATED [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:3',4',5-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] synonym: "S-adenosyl-L-methionine:5,3',4'-trihydroxy-3,7-dimethoxyflavone 4'-O-methyltransferase activity" EXACT [EC:2.1.1.83] xref: EC:2.1.1.83 xref: KEGG:R03456 xref: MetaCyc:2.1.1.83-RXN xref: RHEA:21832 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030759 name: methylquercetagetin 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone + S-adenosyl-L-methionine(1+) = 3',4',5-trihydroxy-3,6,7-trimethoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.84, RHEA:18717] synonym: "6-OMT" RELATED [EC:2.1.1.84] synonym: "flavonol 6-methyltransferase activity" EXACT [EC:2.1.1.84] synonym: "flavonol 6-O-methyltransferase activity" RELATED [EC:2.1.1.84] synonym: "S-adenosyl-L-methionine:3',4',5,6-tetrahydroxy-3,7-dimethoxyflavone 6-O-methyltransferase activity" EXACT [EC:2.1.1.84] xref: EC:2.1.1.84 xref: KEGG:R04505 xref: MetaCyc:2.1.1.84-RXN xref: RHEA:18717 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030760 name: pyridine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + pyridine = N-methylpyridinium + S-adenosyl-L-homocysteine." [EC:2.1.1.87, RHEA:16893] synonym: "pyridine methyltransferase activity" EXACT [EC:2.1.1.87] synonym: "S-adenosyl-L-methionine:pyridine N-methyltransferase activity" EXACT [EC:2.1.1.87] xref: EC:2.1.1.87 xref: KEGG:R02862 xref: MetaCyc:PYRIDINE-N-METHYLTRANSFERASE-RXN xref: reactome:R-HSA-175987 "NNMT transfers CH3 from AdoMet to PY" xref: RHEA:16893 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030761 name: 8-hydroxyquercitin 8-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3,3',4',5,7,8-hexahydroxyflavone + S-adenosyl-L-methionine(1+) = 3,3',4',5,7-pentahydroxy-8-methoxyflavone + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.88, RHEA:16593] synonym: "8-hydroxyquercetin 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-methyltransferase activity" EXACT [EC:2.1.1.88] synonym: "flavonol 8-O-methyltransferase activity" RELATED [EC:2.1.1.88] synonym: "S-adenosyl-L-methionine:3,3',4',5,7,8-hexahydroxyflavone 8-O-methyltransferase activity" EXACT [EC:2.1.1.88] xref: EC:2.1.1.88 xref: KEGG:R04398 xref: MetaCyc:2.1.1.88-RXN xref: RHEA:16593 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030762 name: tetrahydrocolumbamine 2-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-tetrahydrocolumbamine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + H(+) + tetrahydropalmatine." [EC:2.1.1.89, RHEA:22536] synonym: "S-adenosyl-L-methionine:5,8,13,13a-tetrahydrocolumbamine 2-O-methyltransferase activity" EXACT [EC:2.1.1.89] synonym: "tetrahydrocolumbamine methyltransferase activity" EXACT [EC:2.1.1.89] xref: EC:2.1.1.89 xref: KEGG:R04077 xref: MetaCyc:2.1.1.89-RXN xref: RHEA:22536 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030763 name: isobutyraldoxime O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylpropanal oxime + S-adenosyl-L-methionine = 2-methylpropanal O-methyloxime + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.91, RHEA:10996] synonym: "aldoxime methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosyl-L-methionine:2-methylpropanal-oxime O-methyltransferase activity" EXACT [EC:2.1.1.91] synonym: "S-adenosylmethionine:aldoxime O-methyltransferase activity" EXACT [EC:2.1.1.91] xref: EC:2.1.1.91 xref: KEGG:R04169 xref: MetaCyc:ISOBUTYRALDOXIME-O-METHYLTRANSFERASE-RXN xref: RHEA:10996 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030766 name: 11-O-demethyl-17-O-deacetylvindoline O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 11-O-demethyl-17-O-deacetylvindoline = S-adenosyl-L-homocysteine + 17-O-deacetylvindoline." [EC:2.1.1.94] synonym: "11-demethyl-17-deacetylvindoline 11-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:11-O-demethyl-17-O-deacetylvindoline 11-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "S-adenosyl-L-methionine:16-hydroxytabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] synonym: "tabersonine 16-O-methyltransferase activity" EXACT [EC:2.1.1.94] xref: EC:2.1.1.94 xref: MetaCyc:2.1.1.94-RXN xref: RHEA:20992 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030767 name: 3-hydroxyanthranilate 4-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + S-adenosyl-L-methionine = 3-hydroxy-4-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.97, RHEA:17833] synonym: "3-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.97] synonym: "S-adenosyl-L-methionine:3-hydroxyanthranilate 4-C-methyltransferase activity" EXACT [EC:2.1.1.97] xref: EC:2.1.1.97 xref: KEGG:R02667 xref: MetaCyc:2.1.1.97-RXN xref: RHEA:17833 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030768 name: 16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxy-16-methoxy-2,3-dihydrotabersonine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + deacetoxyvindoline + H(+)." [EC:2.1.1.99, RHEA:11336] synonym: "16-methoxy-2,3-dihydro-3-hydroxytabersonine methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "NMT activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:16-methoxy-2,3-dihydro-3-hydroxytabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] synonym: "S-adenosyl-L-methionine:3-hydroxy-16-methoxy-2,3-dihydrotabersonine N-methyltransferase activity" EXACT [EC:2.1.1.99] xref: EC:2.1.1.99 xref: KEGG:R04013 xref: MetaCyc:2.1.1.99-RXN xref: RHEA:11336 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030769 name: macrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + macrocin = S-adenosyl-L-homocysteine + H(+) + tylosin." [EC:2.1.1.101, RHEA:17269] synonym: "macrocin methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine-macrocin O-methyltransferase activity" EXACT [EC:2.1.1.101] synonym: "S-adenosyl-L-methionine:macrocin 3'''-O-methyltransferase activity" EXACT [EC:2.1.1.101] xref: EC:2.1.1.101 xref: KEGG:R02858 xref: MetaCyc:MACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17269 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030770 name: demethylmacrocin O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + demethylmacrocin = S-adenosyl-L-homocysteine + H(+) + macrocin." [EC:2.1.1.102, RHEA:17573] synonym: "demethylmacrocin methyltransferase activity" EXACT [EC:2.1.1.102] synonym: "S-adenosyl-L-methionine:demethylmacrocin 2'''-O-methyltransferase activity" EXACT [EC:2.1.1.102] xref: EC:2.1.1.102 xref: KEGG:R02859 xref: MetaCyc:DEMETHYLMACROCIN-O-METHYLTRANSFERASE-RXN xref: RHEA:17573 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030771 name: N-benzoyl-4-hydroxyanthranilate 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-benzoyl-4-hydroxyanthranilate + S-adenosyl-L-methionine(1+) = N-benzoyl-4-methoxyanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.105, RHEA:17405] synonym: "benzoyl-CoA:anthranilate N-benzoyltransferase" BROAD [EC:2.1.1.105] synonym: "N-benzoyl-4-hydroxyanthranilate 4-methyltransferase activity" EXACT [EC:2.1.1.105] synonym: "S-adenosyl-L-methionine:N-benzoyl-4-O-hydroxyanthranilate 4-O-methyltransferase activity" EXACT [EC:2.1.1.105] xref: EC:2.1.1.105 xref: KEGG:R04421 xref: MetaCyc:2.1.1.105-RXN xref: RHEA:17405 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030772 name: tryptophan 2-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + L-tryptophan = S-adenosyl-L-homocysteine + L-2-methyltryptophan + H(+)." [EC:2.1.1.106, RHEA:17321] synonym: "S-adenosyl-L-methionine:L-tryptophan 2-C-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "S-adenosylmethionine:tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] synonym: "tryptophan 2-methyltransferase activity" EXACT [EC:2.1.1.106] xref: EC:2.1.1.106 xref: KEGG:R08547 xref: MetaCyc:TRYPTOPHAN-2-C-METHYLTRANSFERASE-RXN xref: RHEA:17321 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030773 name: 6-hydroxymellein O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 6-hydroxymellein + S-adenosyl-L-methionine = 6-methoxymellein + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.108, RHEA:15201] synonym: "6-hydroxymellein methyltransferase activity" EXACT [EC:2.1.1.108] synonym: "S-adenosyl-L-methionine:6-hydroxymellein 6-O-methyltransferase activity" EXACT [EC:2.1.1.108] xref: EC:2.1.1.108 xref: KEGG:R03934 xref: MetaCyc:6-HYDROXYMELLEIN-O-METHYLTRANSFERASE-RXN xref: RHEA:15201 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030774 name: anthranilate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + anthranilate = N-methylanthranilate + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.111, RHEA:12180] synonym: "anthranilic acid N-methyltransferase activity" EXACT [EC:2.1.1.111] synonym: "S-adenosyl-L-methionine:anthranilate N-methyltransferase activity" EXACT [EC:2.1.1.111] xref: EC:2.1.1.111 xref: KEGG:R00984 xref: MetaCyc:ANTHRANILATE-N-METHYLTRANSFERASE-RXN xref: RHEA:12180 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030775 name: glucuronoxylan 4-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + glucuronoxylan D-glucuronate = S-adenosyl-L-homocysteine + glucuronoxylan 4-O-methyl-D-glucuronate." [EC:2.1.1.112] synonym: "S-adenosyl-L-methionine:glucuronoxylan-D-glucuronate 4-O-methyltransferase activity" EXACT [EC:2.1.1.112] xref: EC:2.1.1.112 xref: MetaCyc:GLUCURONOXYLAN-4-O-METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030776 name: (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline = S-adenosyl-L-homocysteine + N-methyl-(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline." [EC:2.1.1.115] synonym: "(RS)-tetrahydrobenzylisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "norreticuline N-methyltransferase activity" EXACT [EC:2.1.1.115] synonym: "S-adenosyl-L-methionine:(RS)-1-benzyl-1,2,3,4-tetrahydroisoquinoline N-methyltransferase activity" EXACT [EC:2.1.1.115] xref: EC:2.1.1.115 xref: MetaCyc:2.1.1.115-RXN xref: RHEA:13005 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030777 name: (S)-scoulerine 9-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-scoulerine + S-adenosyl-L-methionine(1+) = (S)-tetrahydrocolumbamine + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.117, RHEA:23808] synonym: "S-adenosyl-L-methionine:(S)-scoclaurine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] synonym: "S-adenosyl-L-methionine:(S)-scoulerine 9-O-methyltransferase activity" EXACT [EC:2.1.1.117] xref: EC:2.1.1.117 xref: KEGG:R03835 xref: MetaCyc:2.1.1.117-RXN xref: RHEA:23808 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030778 name: columbamine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + columbamine = S-adenosyl-L-homocysteine + H(+) + palmatine." [EC:2.1.1.118, RHEA:15373] synonym: "S-adenosyl-L-methionine:columbamine O-methyltransferase activity" EXACT [EC:2.1.1.118] xref: EC:2.1.1.118 xref: KEGG:R03721 xref: MetaCyc:2.1.1.118-RXN xref: RHEA:15373 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030779 name: 10-hydroxydihydrosanguinarine 10-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-hydroxydihydrosanguinarine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydrochelirubine + H(+)." [EC:2.1.1.119, RHEA:18541] synonym: "S-adenosyl-L-methionine:10-hydroxydihydrosanguinarine 10-O-methyltransferase activity" EXACT [EC:2.1.1.119] xref: EC:2.1.1.119 xref: KEGG:R04707 xref: MetaCyc:2.1.1.119-RXN xref: RHEA:18541 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030780 name: 12-hydroxydihydrochelirubine 12-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 12-hydroxydihydrochelirubine + S-adenosyl-L-methionine(1+) = S-adenosyl-L-homocysteine + dihydromacarpine + H(+)." [EC:2.1.1.120, RHEA:21092] synonym: "S-adenosyl-L-methionine:12-hydroxydihydrochelirubine 12-O-methyltransferase activity" EXACT [EC:2.1.1.120] xref: EC:2.1.1.120 xref: KEGG:R04705 xref: MetaCyc:2.1.1.120-RXN xref: RHEA:21092 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030781 name: 6-O-methylnorlaudanosoline 5'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 6-O-methylnorlaudanosoline = S-adenosyl-L-homocysteine + nororientaline." [EC:2.1.1.121] synonym: "S-adenosyl-L-methionine:6-O-methylnorlaudanosoline 5'-O-methyltransferase activity" EXACT [EC:2.1.1.121] xref: EC:2.1.1.121 xref: MetaCyc:2.1.1.121-RXN xref: RHEA:11892 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030782 name: (S)-tetrahydroprotoberberine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-7,8,13,14-tetrahydroprotoberberine = S-adenosyl-L-homocysteine + cis-N-methyl-(S)-7,8,13,14-tetrahydroprotoberberine." [EC:2.1.1.122] synonym: "S-adenosyl-L-methionine:(S)-7,8,13,14-tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] synonym: "tetrahydroprotoberberine cis-N-methyltransferase activity" EXACT [EC:2.1.1.122] xref: EC:2.1.1.122 xref: MetaCyc:2.1.1.122-RXN xref: RHEA:12805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030783 name: [cytochrome c]-methionine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [cytochrome c]-methionine = S-adenosyl-L-homocysteine + [cytochrome c]-S-methyl-methionine." [EC:2.1.1.123] synonym: "cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] synonym: "S-adenosyl-L-methionine:cytochrome c-methionine S-methyltransferase activity" EXACT [EC:2.1.1.123] xref: EC:2.1.1.123 xref: MetaCyc:2.1.1.123-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030784 name: 3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3'-hydroxy-N-methyl-(S)-coclaurine = S-adenosyl-L-homocysteine + (S)-reticuline." [EC:2.1.1.116] synonym: "S-adenosyl-L-methionine:3'-hydroxy-N-methyl-(S)-coclaurine 4'-O-methyltransferase activity" EXACT [EC:2.1.1.116] xref: EC:2.1.1.116 xref: MetaCyc:2.1.1.116-RXN xref: RHEA:17789 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030785 name: [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine = S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine." [EC:2.1.1.127] synonym: "ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit epsilonN-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate carboxylase-lysine N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO LSMT activity" EXACT [EC:2.1.1.127] synonym: "RuBisCO methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.127] synonym: "S-adenosyl-L-methionine:3-phospho-D-glycerate-carboxy-lyase (dimerizing)-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.127] xref: EC:2.1.1.127 xref: MetaCyc:2.1.1.127-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030786 name: (RS)-norcoclaurine 6-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (RS)-norcoclaurine = S-adenosyl-L-homocysteine + (RS)-coclaurine." [EC:2.1.1.128] synonym: "S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase activity" EXACT [EC:2.1.1.128] xref: EC:2.1.1.128 xref: MetaCyc:2.1.1.128-RXN xref: RHEA:19941 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030787 name: inositol 4-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine(1+) + myo-inositol = 1D-4-O-methyl-myo-inositol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.129, RHEA:23248] synonym: "myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "myo-inositol 6-O-methyltransferase activity" RELATED [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:1D-myo-inositol 4-methyltransferase activity" EXACT [EC:2.1.1.129] synonym: "S-adenosyl-L-methionine:myo-inositol 4-O-methyltransferase activity" EXACT [EC:2.1.1.129] xref: EC:2.1.1.129 xref: KEGG:R01190 xref: MetaCyc:2.1.1.129-RXN xref: RHEA:23248 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030788 name: precorrin-2 C20-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A." [EC:2.1.1.130, RHEA:16841] synonym: "S-adenosyl-L-methionine--precorrin-2 methyltransferase activity" EXACT [EC:2.1.1.130] synonym: "S-adenosyl-L-methionine:precorrin-4 C20-methyltransferase activity" EXACT [EC:2.1.1.130] xref: EC:2.1.1.130 xref: KEGG:R03948 xref: MetaCyc:2.1.1.130-RXN xref: RHEA:16841 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030789 name: precorrin-3B C17-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4." [EC:2.1.1.131] synonym: "CobJ" RELATED [EC:2.1.1.131] synonym: "precorrin-3 methylase activity" EXACT [EC:2.1.1.131] synonym: "precorrin-3 methyltransferase activity" EXACT [EC:2.1.1.131] synonym: "S-adenosyl-L-methionine:precorrin-3B C17-methyltransferase activity" EXACT [EC:2.1.1.131] xref: EC:2.1.1.131 xref: MetaCyc:2.1.1.131-RXN xref: RHEA:12761 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030790 name: chlorophenol O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole." [EC:2.1.1.136] synonym: "halogenated phenol O-methyltransferase activity" BROAD [EC:2.1.1.136] synonym: "S-adenosyl-L-methionine:trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] synonym: "trichlorophenol O-methyltransferase activity" EXACT [EC:2.1.1.136] xref: EC:2.1.1.136 xref: MetaCyc:2.1.1.136-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030791 name: arsenite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate." [EC:2.1.1.137] comment: Note that the enzyme arsenite methyltransferase also has methylarsonite methyltransferase activity (GO:0030792). synonym: "S-adenosyl-L-methionine:arsenic(III) methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:arsenite As-methyltransferase activity" EXACT [EC:2.1.1.137] synonym: "S-adenosyl-L-methionine:methylarsonite As-methyltransferase activity" EXACT [EC:2.1.1.137] xref: EC:2.1.1.137 xref: MetaCyc:2.1.1.137-RXN xref: reactome:R-HSA-5696213 "AS3MT transfers CH3 from AdoMet to methylarsonite" xref: reactome:R-HSA-5696220 "AS3MT transfers CH3 from AdoMet to arsenite(3-)" xref: UM-BBD_reactionID:r0805 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030792 name: methylarsonite methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate." [EC:2.1.1.138] comment: Note that EC:2.1.1.138 was deleted from EC as the reaction is performed by arsenite methyltransferase (EC:2.1.1.137). xref: EC:2.1.1 xref: MetaCyc:2.1.1.138-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030793 name: 3'-demethylstaurosporine O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine." [EC:2.1.1.139, RHEA:11696] synonym: "3'-demethoxy-3'-hydroxystaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "S-adenosyl-L-methionine:3'-demethylstaurosporine O-methyltransferase activity" EXACT [EC:2.1.1.139] synonym: "staurosporine synthase activity" EXACT [EC:2.1.1.139] xref: EC:2.1.1.139 xref: KEGG:R05757 xref: MetaCyc:2.1.1.139-RXN xref: RHEA:11696 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030794 name: (S)-coclaurine-N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine." [EC:2.1.1.140] synonym: "S-adenosyl-L-methionine:(S)-coclaurine-N-methyltransferase activity" EXACT [EC:2.1.1.140] xref: EC:2.1.1.140 xref: MetaCyc:2.1.1.140-RXN xref: RHEA:17409 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030795 name: jasmonate O-methyltransferase activity namespace: molecular_function alt_id: GO:0045546 def: "Catalysis of the reaction: S-adenosyl-L-methionine + jasmonate = S-adenosyl-L-homocysteine + methyljasmonate." [EC:2.1.1.141] synonym: "jasmonic acid carboxyl methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonate O-methyltransferase activity" EXACT [EC:2.1.1.141] synonym: "S-adenosyl-L-methionine:jasmonic acid carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.141 xref: MetaCyc:RXN1F-28 xref: RHEA:13349 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030796 name: cycloartenol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.142, RHEA:13137] synonym: "S-adenosyl-L-methionine:cycloartenol 24-C-methyltransferase activity" EXACT [EC:2.1.1.142] synonym: "sterol C-methyltransferase activity" BROAD [EC:2.1.1.142] xref: EC:2.1.1.142 xref: KEGG:R05760 xref: MetaCyc:2.1.1.142-RXN xref: RHEA:13137 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030797 name: 24-methylenesterol C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+)." [EC:2.1.1.143, RHEA:21044] synonym: "24-methylenelophenol C-24(1)-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "24-methylenelophenol C-241-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "S-adenosyl-L-methionine:24-methylenelophenol C-methyltransferase activity" EXACT [EC:2.1.1.143] synonym: "SMT(2) activity" NARROW [EC:2.1.1.143] synonym: "SMT2" RELATED [EC:2.1.1.143] xref: EC:2.1.1.143 xref: KEGG:R05776 xref: MetaCyc:2.1.1.143-RXN xref: RHEA:21044 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030798 name: trans-aconitate 2-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine." [EC:2.1.1.144, RHEA:14969] synonym: "S-adenosyl-L-methionine:(E)-prop-1-ene-1,2,3-tricarboxylate 2'-O-methyltransferase activity" EXACT [EC:2.1.1.144] xref: EC:2.1.1.144 xref: KEGG:R05763 xref: MetaCyc:RXN0-2441 xref: RHEA:14969 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0030799 name: obsolete regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cyclic nucleotide metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030800 name: obsolete negative regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide metabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide metabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030801 name: obsolete positive regulation of cyclic nucleotide metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide metabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide metabolism" EXACT [] synonym: "stimulation of cyclic nucleotide metabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide metabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030802 name: obsolete regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cyclic nucleotide anabolism" EXACT [] synonym: "regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "regulation of cyclic nucleotide formation" EXACT [] synonym: "regulation of cyclic nucleotide synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030803 name: obsolete negative regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "downregulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "inhibition of cyclic nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of cyclic nucleotide anabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "negative regulation of cyclic nucleotide formation" EXACT [] synonym: "negative regulation of cyclic nucleotide synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030804 name: obsolete positive regulation of cyclic nucleotide biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of cyclic nucleotide anabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide biosynthesis" EXACT [] synonym: "positive regulation of cyclic nucleotide formation" EXACT [] synonym: "positive regulation of cyclic nucleotide synthesis" EXACT [] synonym: "stimulation of cyclic nucleotide biosynthetic process" NARROW [] synonym: "up regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of cyclic nucleotide biosynthetic process" EXACT [] synonym: "upregulation of cyclic nucleotide biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030805 name: regulation of cyclic nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] synonym: "regulation of cyclic nucleotide breakdown" EXACT [] synonym: "regulation of cyclic nucleotide catabolism" EXACT [] synonym: "regulation of cyclic nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process relationship: regulates GO:0009214 ! cyclic nucleotide catabolic process [Term] id: GO:0030806 name: obsolete negative regulation of cyclic nucleotide catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "down-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "downregulation of cyclic nucleotide catabolic process" EXACT [] synonym: "inhibition of cyclic nucleotide catabolic process" NARROW [] synonym: "negative regulation of cyclic nucleotide breakdown" EXACT [] synonym: "negative regulation of cyclic nucleotide catabolism" EXACT [] synonym: "negative regulation of cyclic nucleotide degradation" EXACT [] is_obsolete: true [Term] id: GO:0030807 name: obsolete positive regulation of cyclic nucleotide catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways resulting in the breakdown of cyclic nucleotides." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cyclic nucleotide catabolic process" NARROW [] synonym: "positive regulation of cyclic nucleotide breakdown" EXACT [] synonym: "positive regulation of cyclic nucleotide catabolism" EXACT [] synonym: "positive regulation of cyclic nucleotide degradation" EXACT [] synonym: "stimulation of cyclic nucleotide catabolic process" NARROW [] synonym: "up regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "up-regulation of cyclic nucleotide catabolic process" EXACT [] synonym: "upregulation of cyclic nucleotide catabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030808 name: regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "regulation of nucleotide anabolism" EXACT [] synonym: "regulation of nucleotide biosynthesis" EXACT [] synonym: "regulation of nucleotide formation" EXACT [] synonym: "regulation of nucleotide synthesis" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030809 name: negative regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide biosynthetic process" EXACT [] synonym: "down-regulation of nucleotide biosynthetic process" EXACT [] synonym: "downregulation of nucleotide biosynthetic process" EXACT [] synonym: "inhibition of nucleotide biosynthetic process" NARROW [] synonym: "negative regulation of nucleotide anabolism" EXACT [] synonym: "negative regulation of nucleotide biosynthesis" EXACT [] synonym: "negative regulation of nucleotide formation" EXACT [] synonym: "negative regulation of nucleotide synthesis" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process relationship: negatively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030810 name: positive regulation of nucleotide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides." [GOC:mah] synonym: "activation of nucleotide biosynthetic process" NARROW [] synonym: "positive regulation of nucleotide anabolism" EXACT [] synonym: "positive regulation of nucleotide biosynthesis" EXACT [] synonym: "positive regulation of nucleotide formation" EXACT [] synonym: "positive regulation of nucleotide synthesis" EXACT [] synonym: "stimulation of nucleotide biosynthetic process" NARROW [] synonym: "up regulation of nucleotide biosynthetic process" EXACT [] synonym: "up-regulation of nucleotide biosynthetic process" EXACT [] synonym: "upregulation of nucleotide biosynthetic process" EXACT [] is_a: GO:0030808 ! regulation of nucleotide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process relationship: positively_regulates GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0030811 name: regulation of nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "regulation of nucleotide breakdown" EXACT [] synonym: "regulation of nucleotide catabolism" EXACT [] synonym: "regulation of nucleotide degradation" EXACT [] is_a: GO:0006140 ! regulation of nucleotide metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030812 name: negative regulation of nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "down regulation of nucleotide catabolic process" EXACT [] synonym: "down-regulation of nucleotide catabolic process" EXACT [] synonym: "downregulation of nucleotide catabolic process" EXACT [] synonym: "inhibition of nucleotide catabolic process" NARROW [] synonym: "negative regulation of nucleotide breakdown" EXACT [] synonym: "negative regulation of nucleotide catabolism" EXACT [] synonym: "negative regulation of nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0045980 ! negative regulation of nucleotide metabolic process relationship: negatively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030813 name: positive regulation of nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides." [GOC:mah] synonym: "activation of nucleotide catabolic process" NARROW [] synonym: "positive regulation of nucleotide breakdown" EXACT [] synonym: "positive regulation of nucleotide catabolism" EXACT [] synonym: "positive regulation of nucleotide degradation" EXACT [] synonym: "stimulation of nucleotide catabolic process" NARROW [] synonym: "up regulation of nucleotide catabolic process" EXACT [] synonym: "up-regulation of nucleotide catabolic process" EXACT [] synonym: "upregulation of nucleotide catabolic process" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045981 ! positive regulation of nucleotide metabolic process relationship: positively_regulates GO:0009166 ! nucleotide catabolic process [Term] id: GO:0030814 name: obsolete regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "regulation of 3',5' cAMP metabolism" EXACT [] synonym: "regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "regulation of cAMP metabolism" EXACT [] synonym: "regulation of cyclic AMP metabolic process" EXACT [] synonym: "regulation of cyclic AMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030815 name: obsolete negative regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cAMP metabolic process" EXACT [] synonym: "down-regulation of cAMP metabolic process" EXACT [] synonym: "downregulation of cAMP metabolic process" EXACT [] synonym: "inhibition of cAMP metabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP metabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "negative regulation of cAMP metabolism" EXACT [] synonym: "negative regulation of cyclic AMP metabolic process" EXACT [] synonym: "negative regulation of cyclic AMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030816 name: obsolete positive regulation of cAMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cAMP metabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP metabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP metabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate metabolism" EXACT [] synonym: "positive regulation of cAMP metabolism" EXACT [] synonym: "positive regulation of cyclic AMP metabolic process" EXACT [] synonym: "positive regulation of cyclic AMP metabolism" EXACT [] synonym: "stimulation of cAMP metabolic process" NARROW [] synonym: "up regulation of cAMP metabolic process" EXACT [] synonym: "up-regulation of cAMP metabolic process" EXACT [] synonym: "upregulation of cAMP metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030817 name: obsolete regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that the term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "regulation of cAMP anabolism" EXACT [] synonym: "regulation of cAMP biosynthesis" EXACT [] synonym: "regulation of cAMP formation" EXACT [] synonym: "regulation of cAMP synthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthesis" EXACT [] synonym: "regulation of cyclic AMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030818 name: obsolete negative regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that the term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "down regulation of cAMP biosynthetic process" EXACT [] synonym: "down-regulation of cAMP biosynthetic process" EXACT [] synonym: "downregulation of cAMP biosynthetic process" EXACT [] synonym: "inhibition of cAMP biosynthetic process" NARROW [] synonym: "negative regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "negative regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "negative regulation of cAMP anabolism" EXACT [] synonym: "negative regulation of cAMP biosynthesis" EXACT [] synonym: "negative regulation of cAMP formation" EXACT [] synonym: "negative regulation of cAMP synthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthesis" EXACT [] synonym: "negative regulation of cyclic AMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030819 name: obsolete positive regulation of cAMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents a molecular function. See https://github.com/geneontology/go-ontology/issues/14718 synonym: "activation of cAMP biosynthetic process" NARROW [] synonym: "positive regulation of 3',5' cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5' cAMP biosynthetic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthesis" EXACT [] synonym: "positive regulation of 3',5'-cAMP biosynthetic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "positive regulation of cAMP anabolism" EXACT [] synonym: "positive regulation of cAMP biosynthesis" EXACT [] synonym: "positive regulation of cAMP formation" EXACT [] synonym: "positive regulation of cAMP synthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthesis" EXACT [] synonym: "positive regulation of cyclic AMP biosynthetic process" EXACT [] synonym: "stimulation of cAMP biosynthetic process" NARROW [] synonym: "up regulation of cAMP biosynthetic process" EXACT [] synonym: "up-regulation of cAMP biosynthetic process" EXACT [] synonym: "upregulation of cAMP biosynthetic process" EXACT [] is_obsolete: true [Term] id: GO:0030820 name: obsolete regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "regulation of 3',5' cAMP catabolism" EXACT [] synonym: "regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "regulation of cAMP breakdown" EXACT [] synonym: "regulation of cAMP catabolism" EXACT [] synonym: "regulation of cAMP degradation" EXACT [] synonym: "regulation of cyclic AMP catabolic process" EXACT [] synonym: "regulation of cyclic AMP catabolism" EXACT [] is_obsolete: true [Term] id: GO:0030821 name: obsolete negative regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "down regulation of cAMP catabolic process" EXACT [] synonym: "down-regulation of cAMP catabolic process" EXACT [] synonym: "downregulation of cAMP catabolic process" EXACT [] synonym: "inhibition of cAMP catabolic process" NARROW [] synonym: "negative regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5' cAMP catabolism" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "negative regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "negative regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "negative regulation of cAMP breakdown" EXACT [] synonym: "negative regulation of cAMP catabolism" EXACT [] synonym: "negative regulation of cAMP degradation" EXACT [] synonym: "negative regulation of cyclic AMP catabolic process" EXACT [] synonym: "negative regulation of cyclic AMP catabolism" EXACT [] is_obsolete: true [Term] id: GO:0030822 name: obsolete positive regulation of cAMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cAMP catabolic process" NARROW [] synonym: "positive regulation of 3',5' cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5' cAMP catabolism" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolic process" EXACT [] synonym: "positive regulation of 3',5'-cAMP catabolism" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "positive regulation of adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "positive regulation of cAMP breakdown" EXACT [] synonym: "positive regulation of cAMP catabolism" EXACT [] synonym: "positive regulation of cAMP degradation" EXACT [] synonym: "positive regulation of cyclic AMP catabolic process" EXACT [] synonym: "positive regulation of cyclic AMP catabolism" EXACT [] synonym: "stimulation of cAMP catabolic process" NARROW [] synonym: "up regulation of cAMP catabolic process" EXACT [] synonym: "up-regulation of cAMP catabolic process" EXACT [] synonym: "upregulation of cAMP catabolic process" EXACT [] is_obsolete: true consider: GO:0071878 [Term] id: GO:0030823 name: obsolete regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030824 name: obsolete negative regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP metabolic process" EXACT [] synonym: "down-regulation of cGMP metabolic process" EXACT [] synonym: "downregulation of cGMP metabolic process" EXACT [] synonym: "inhibition of cGMP metabolic process" NARROW [] synonym: "negative regulation of cGMP metabolism" EXACT [] is_obsolete: true [Term] id: GO:0030825 name: obsolete positive regulation of cGMP metabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP metabolic process" NARROW [] synonym: "positive regulation of cGMP metabolism" EXACT [] synonym: "stimulation of cGMP metabolic process" NARROW [] synonym: "up regulation of cGMP metabolic process" EXACT [] synonym: "up-regulation of cGMP metabolic process" EXACT [] synonym: "upregulation of cGMP metabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030826 name: obsolete regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP anabolism" EXACT [] synonym: "regulation of cGMP biosynthesis" EXACT [] synonym: "regulation of cGMP formation" EXACT [] synonym: "regulation of cGMP synthesis" EXACT [] is_obsolete: true [Term] id: GO:0030827 name: obsolete negative regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP biosynthetic process" EXACT [] synonym: "down-regulation of cGMP biosynthetic process" EXACT [] synonym: "downregulation of cGMP biosynthetic process" EXACT [] synonym: "inhibition of cGMP biosynthetic process" NARROW [] synonym: "negative regulation of cGMP anabolism" EXACT [] synonym: "negative regulation of cGMP biosynthesis" EXACT [] synonym: "negative regulation of cGMP formation" EXACT [] synonym: "negative regulation of cGMP synthesis" EXACT [] is_obsolete: true consider: GO:0030251 [Term] id: GO:0030828 name: obsolete positive regulation of cGMP biosynthetic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP biosynthetic process" NARROW [] synonym: "positive regulation of cGMP anabolism" EXACT [] synonym: "positive regulation of cGMP biosynthesis" EXACT [] synonym: "positive regulation of cGMP formation" EXACT [] synonym: "positive regulation of cGMP synthesis" EXACT [] synonym: "stimulation of cGMP biosynthetic process" NARROW [] synonym: "up regulation of cGMP biosynthetic process" EXACT [] synonym: "up-regulation of cGMP biosynthetic process" EXACT [] synonym: "upregulation of cGMP biosynthetic process" EXACT [] is_obsolete: true consider: GO:0004383 [Term] id: GO:0030829 name: obsolete regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represent the regulation of a signaling pathway, not regulation of metabolism. synonym: "regulation of cGMP breakdown" EXACT [] synonym: "regulation of cGMP catabolism" EXACT [] synonym: "regulation of cGMP degradation" EXACT [] is_obsolete: true [Term] id: GO:0030830 name: obsolete negative regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that the term represents the regulation of a signaling pathway, and not regulation of metabolism. synonym: "down regulation of cGMP catabolic process" EXACT [] synonym: "down-regulation of cGMP catabolic process" EXACT [] synonym: "downregulation of cGMP catabolic process" EXACT [] synonym: "inhibition of cGMP catabolic process" NARROW [] synonym: "negative regulation of cGMP breakdown" EXACT [] synonym: "negative regulation of cGMP catabolism" EXACT [] synonym: "negative regulation of cGMP degradation" EXACT [] is_obsolete: true [Term] id: GO:0030831 name: obsolete positive regulation of cGMP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cGMP." [GOC:mah] comment: The reason for obsoletion is that this term represents the regulation of a signaling pathway, not regulation of metabolism. synonym: "activation of cGMP catabolic process" NARROW [] synonym: "positive regulation of cGMP breakdown" EXACT [] synonym: "positive regulation of cGMP catabolism" EXACT [] synonym: "positive regulation of cGMP degradation" EXACT [] synonym: "stimulation of cGMP catabolic process" NARROW [] synonym: "up regulation of cGMP catabolic process" EXACT [] synonym: "up-regulation of cGMP catabolic process" EXACT [] synonym: "upregulation of cGMP catabolic process" EXACT [] is_obsolete: true [Term] id: GO:0030832 name: regulation of actin filament length namespace: biological_process def: "Any process that controls the length of actin filaments in a cell." [GOC:dph, GOC:mah] comment: Note that the syntax of the definition of this term is different from the usual regulation syntax because it describes regulation of a trait rather than regulation of a process. is_a: GO:0032535 ! regulation of cellular component size is_a: GO:0032956 ! regulation of actin cytoskeleton organization [Term] id: GO:0030833 name: regulation of actin filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament." [GOC:mah] synonym: "regulation of actin polymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization relationship: regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030834 name: regulation of actin filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament." [GOC:mah] synonym: "regulation of actin depolymerization" EXACT [] is_a: GO:0008064 ! regulation of actin polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization relationship: regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030835 name: negative regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030044 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin polymerization ; GO:0030837'). synonym: "actin filament stabilization" EXACT [] synonym: "down regulation of actin filament depolymerization" EXACT [] synonym: "down-regulation of actin filament depolymerization" EXACT [] synonym: "downregulation of actin filament depolymerization" EXACT [] synonym: "inhibition of actin filament depolymerization" NARROW [] synonym: "negative regulation of actin depolymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1901880 ! negative regulation of protein depolymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization relationship: negatively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030836 name: positive regulation of actin filament depolymerization namespace: biological_process alt_id: GO:0030045 def: "Any process that activates or increases the frequency, rate or extent of actin depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin polymerization ; GO:0030838'). synonym: "actin filament destabilization" EXACT [] synonym: "activation of actin filament depolymerization" NARROW [] synonym: "positive regulation of actin depolymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament depolymerization" NARROW [] synonym: "up regulation of actin filament depolymerization" EXACT [] synonym: "up-regulation of actin filament depolymerization" EXACT [] synonym: "upregulation of actin filament depolymerization" EXACT [] is_a: GO:0030834 ! regulation of actin filament depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization relationship: positively_regulates GO:0030042 ! actin filament depolymerization [Term] id: GO:0030837 name: negative regulation of actin filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of actin polymerization and/or depolymerization ; GO:0045757' (sibling term 'negative regulation of actin depolymerization ; GO:0030835'). synonym: "down regulation of actin filament polymerization" EXACT [] synonym: "down-regulation of actin filament polymerization" EXACT [] synonym: "downregulation of actin filament polymerization" EXACT [] synonym: "inhibition of actin filament polymerization" NARROW [] synonym: "negative regulation of actin polymerization" EXACT [] synonym: "negative regulation of actin polymerization and/or depolymerization" BROAD [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization relationship: negatively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030838 name: positive regulation of actin filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of actin polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of actin polymerization and/or depolymerization ; GO:0045758' (sibling term 'positive regulation of actin depolymerization ; GO:0030836'). synonym: "activation of actin filament polymerization" NARROW [] synonym: "positive regulation of actin polymerization" EXACT [] synonym: "positive regulation of actin polymerization and/or depolymerization" BROAD [] synonym: "stimulation of actin filament polymerization" NARROW [] synonym: "up regulation of actin filament polymerization" EXACT [] synonym: "up-regulation of actin filament polymerization" EXACT [] synonym: "upregulation of actin filament polymerization" EXACT [] is_a: GO:0030833 ! regulation of actin filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization relationship: positively_regulates GO:0030041 ! actin filament polymerization [Term] id: GO:0030839 name: regulation of intermediate filament polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament." [GOC:mah] is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization relationship: regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030840 name: negative regulation of intermediate filament polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament depolymerization ; GO:0030843'). synonym: "down regulation of intermediate filament polymerization" EXACT [] synonym: "down-regulation of intermediate filament polymerization" EXACT [] synonym: "downregulation of intermediate filament polymerization" EXACT [] synonym: "inhibition of intermediate filament polymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030841 name: positive regulation of intermediate filament polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament depolymerization ; GO:0030844'). synonym: "activation of intermediate filament polymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament polymerization" NARROW [] synonym: "up regulation of intermediate filament polymerization" EXACT [] synonym: "up-regulation of intermediate filament polymerization" EXACT [] synonym: "upregulation of intermediate filament polymerization" EXACT [] is_a: GO:0030839 ! regulation of intermediate filament polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0045107 ! intermediate filament polymerization [Term] id: GO:0030842 name: regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament." [GOC:mah] is_a: GO:0045108 ! regulation of intermediate filament polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization relationship: regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030843 name: negative regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'negative regulation of intermediate filament polymerization and/or depolymerization ; GO:0045825' (sibling term 'negative regulation of intermediate filament polymerization ; GO:0030840'). synonym: "down regulation of intermediate filament depolymerization" EXACT [] synonym: "down-regulation of intermediate filament depolymerization" EXACT [] synonym: "downregulation of intermediate filament depolymerization" EXACT [] synonym: "inhibition of intermediate filament depolymerization" NARROW [] synonym: "negative regulation of intermediate filament polymerization and/or depolymerization" BROAD [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1901880 ! negative regulation of protein depolymerization relationship: negatively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030844 name: positive regulation of intermediate filament depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization." [GOC:mah] comment: Note that this term was split from 'positive regulation of intermediate filament polymerization and/or depolymerization ; GO:0045826' (sibling term 'positive regulation of intermediate filament polymerization ; GO:0030841'). synonym: "activation of intermediate filament depolymerization" NARROW [] synonym: "positive regulation of intermediate filament polymerization and/or depolymerization" BROAD [] synonym: "stimulation of intermediate filament depolymerization" NARROW [] synonym: "up regulation of intermediate filament depolymerization" EXACT [] synonym: "up-regulation of intermediate filament depolymerization" EXACT [] synonym: "upregulation of intermediate filament depolymerization" EXACT [] is_a: GO:0030842 ! regulation of intermediate filament depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1901881 ! positive regulation of protein depolymerization relationship: positively_regulates GO:0045106 ! intermediate filament depolymerization [Term] id: GO:0030845 name: phospholipase C-inhibiting G protein-coupled receptor signaling pathway namespace: biological_process def: "A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, PMID:8280098] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase C (PLC) inhibition. synonym: "G-protein-coupled inhibitory pathway of phospholipase C" EXACT [PMID:8280098] synonym: "GPCR signaling pathway coupled to inhibition of phospholipase C activity" EXACT [GOC:signaling] synonym: "GPCR signaling pathway via inhibition of PLC" EXACT [GOC:signaling] synonym: "inhibition of phospholipase C activity involved in G-protein coupled receptor signalling pathway" NARROW [GOC:mah] synonym: "phospholipase C inhibition" RELATED [GOC:dph, GOC:tb] synonym: "phospholipase C-inhibiting G-protein coupled receptor signaling pathway" EXACT [] synonym: "PLC-inhibiting GPCR signaling pathway" EXACT [GOC:signaling] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0030846 name: termination of RNA polymerase II transcription, poly(A)-coupled namespace: biological_process def: "The process in which transcription of polyadenylated RNA polymerase II transcripts is terminated; cleavage and polyadenylylation of the mRNA 3' end is coupled to transcription termination." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "termination of RNA polymerase II transcription, polyadenylation-coupled" RELATED [] synonym: "transcription termination from Pol II promoter, poly(A) coupled" RELATED [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A) coupled" RELATED [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030847 name: termination of RNA polymerase II transcription, exosome-dependent namespace: biological_process def: "The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end." [GOC:txnOH, PMID:12944462, PMID:18679429] synonym: "termination of RNA polymerase II transcription, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, poly(A)-independent" EXACT [] synonym: "transcription termination from Pol II promoter, RNA polymerase(A)-independent" EXACT [] is_a: GO:0006369 ! termination of RNA polymerase II transcription [Term] id: GO:0030848 name: threo-3-hydroxyaspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-3-hydroxy-L-aspartate = NH(4)(+) + oxaloacetate." [EC:4.3.1.16, RHEA:12424] synonym: "3-hydroxyaspartate dehydratase activity" BROAD [GOC:mcc, PMID:10481099] synonym: "L-threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase (oxaloacetate-forming)" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxy-L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.16] synonym: "threo-3-hydroxyaspartate dehydratase activity" EXACT [EC:4.3.1.16] xref: EC:4.3.1.16 xref: KEGG:R05758 xref: MetaCyc:4.3.1.16-RXN xref: RHEA:12424 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0030849 name: autosome namespace: cellular_component def: "Any chromosome other than a sex chromosome." [GOC:mah] comment: Note that this term is mainly relevant in organisms that have both sex chromosomes and non-sex-determining chromosomes in an individual organism. xref: Wikipedia:Autosome is_a: GO:0005694 ! chromosome [Term] id: GO:0030850 name: prostate gland development namespace: biological_process def: "The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid." [PMID:11839751] synonym: "prostate development" EXACT [] is_a: GO:0048608 ! reproductive structure development is_a: GO:0048732 ! gland development relationship: part_of GO:0001655 ! urogenital system development [Term] id: GO:0030851 name: granulocyte differentiation namespace: biological_process def: "The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils." [GOC:ecd, http://life.nthu.edu.tw/~g864204/dict-search1.htm] synonym: "granulocyte cell differentiation" EXACT [] is_a: GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0030852 name: regulation of granulocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of granulocyte differentiation." [GOC:mah] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation relationship: regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030853 name: negative regulation of granulocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "down regulation of granulocyte differentiation" EXACT [] synonym: "down-regulation of granulocyte differentiation" EXACT [] synonym: "downregulation of granulocyte differentiation" EXACT [] synonym: "inhibition of granulocyte differentiation" NARROW [] is_a: GO:0002762 ! negative regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: negatively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030854 name: positive regulation of granulocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of granulocyte differentiation." [GOC:mah] synonym: "activation of granulocyte differentiation" NARROW [] synonym: "stimulation of granulocyte differentiation" NARROW [] synonym: "up regulation of granulocyte differentiation" EXACT [] synonym: "up-regulation of granulocyte differentiation" EXACT [] synonym: "upregulation of granulocyte differentiation" EXACT [] is_a: GO:0002763 ! positive regulation of myeloid leukocyte differentiation is_a: GO:0030852 ! regulation of granulocyte differentiation relationship: positively_regulates GO:0030851 ! granulocyte differentiation [Term] id: GO:0030855 name: epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium." [GOC:ecd, PMID:11839751] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0030856 name: regulation of epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:2000026 ! regulation of multicellular organismal development relationship: regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030857 name: negative regulation of epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "down regulation of epithelial cell differentiation" EXACT [] synonym: "down-regulation of epithelial cell differentiation" EXACT [] synonym: "downregulation of epithelial cell differentiation" EXACT [] synonym: "inhibition of epithelial cell differentiation" NARROW [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045596 ! negative regulation of cell differentiation relationship: negatively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030858 name: positive regulation of epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation." [GOC:mah] synonym: "activation of epithelial cell differentiation" NARROW [] synonym: "stimulation of epithelial cell differentiation" NARROW [] synonym: "up regulation of epithelial cell differentiation" EXACT [] synonym: "up-regulation of epithelial cell differentiation" EXACT [] synonym: "upregulation of epithelial cell differentiation" EXACT [] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0045597 ! positive regulation of cell differentiation relationship: positively_regulates GO:0030855 ! epithelial cell differentiation [Term] id: GO:0030859 name: polarized epithelial cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:mah] is_a: GO:0030855 ! epithelial cell differentiation relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0030860 name: regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:1905330 ! regulation of morphogenesis of an epithelium is_a: GO:2000027 ! regulation of animal organ morphogenesis relationship: regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030861 name: negative regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "down regulation of polarized epithelial cell differentiation" EXACT [] synonym: "down-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "downregulation of polarized epithelial cell differentiation" EXACT [] synonym: "inhibition of polarized epithelial cell differentiation" NARROW [] is_a: GO:0030857 ! negative regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation is_a: GO:1905331 ! negative regulation of morphogenesis of an epithelium relationship: negatively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030862 name: positive regulation of polarized epithelial cell differentiation namespace: biological_process def: "Any process that activates or increases the rate or extent of polarized epithelial cell differentiation." [GOC:mah] synonym: "activation of polarized epithelial cell differentiation" NARROW [] synonym: "stimulation of polarized epithelial cell differentiation" NARROW [] synonym: "up regulation of polarized epithelial cell differentiation" EXACT [] synonym: "up-regulation of polarized epithelial cell differentiation" EXACT [] synonym: "upregulation of polarized epithelial cell differentiation" EXACT [] is_a: GO:0030858 ! positive regulation of epithelial cell differentiation is_a: GO:0030860 ! regulation of polarized epithelial cell differentiation is_a: GO:1905332 ! positive regulation of morphogenesis of an epithelium relationship: positively_regulates GO:0030859 ! polarized epithelial cell differentiation [Term] id: GO:0030863 name: cortical cytoskeleton namespace: cellular_component def: "The portion of the cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0005856 ! cytoskeleton is_a: GO:0044448 ! cell cortex part [Term] id: GO:0030864 name: cortical actin cytoskeleton namespace: cellular_component def: "The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0030865 name: cortical cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] synonym: "cortical cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0030866 name: cortical actin cytoskeleton organization namespace: biological_process alt_id: GO:0033109 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:pf] synonym: "actin cortex stabilization" EXACT [] synonym: "cortical actin cytoskeleton organisation" EXACT [GOC:curators] synonym: "cortical actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "cortical actin cytoskeleton stabilization" EXACT [] synonym: "cortical resistance" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030865 ! cortical cytoskeleton organization [Term] id: GO:0030867 name: rough endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the rough endoplasmic reticulum." [GOC:mah] synonym: "RER membrane" EXACT [NIF_Subcellular:sao3089754107] synonym: "rough ER membrane" EXACT [] xref: NIF_Subcellular:sao3089754107 is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005791 ! rough endoplasmic reticulum [Term] id: GO:0030868 name: smooth endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the smooth endoplasmic reticulum." [GOC:mah] synonym: "SER membrane" EXACT [] synonym: "smooth ER membrane" EXACT [] xref: NIF_Subcellular:sao1596955044 is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0097425 ! smooth endoplasmic reticulum part is_a: GO:0098588 ! bounding membrane of organelle [Term] id: GO:0030869 name: RENT complex namespace: cellular_component def: "A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit." [PMID:12196389] is_a: GO:0005677 ! chromatin silencing complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0030870 name: Mre11 complex namespace: cellular_component def: "Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins." [GOC:mah, GOC:vw, PMID:11988766, PMID:17674145] synonym: "MRN complex" EXACT [] synonym: "MRX complex" EXACT [] synonym: "Rad50 complex" EXACT [] synonym: "RAD50-MRE11-NBN complex" EXACT [CORUM:2767] synonym: "Rad50-Rad32-Nbs1 complex" EXACT [] synonym: "RMX complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030874 name: nucleolar chromatin namespace: cellular_component def: "The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA." [GOC:mah] is_a: GO:0044452 ! nucleolar part is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0030875 name: rDNA protrusion namespace: cellular_component def: "Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining." [PMID:1629244] comment: Note that this component is characterized in Schizosaccharomyces, particularly with respect to the DAPI staining pattern. synonym: "ribosomal DNA protrusion" EXACT [] is_a: GO:0044452 ! nucleolar part is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0030874 ! nucleolar chromatin [Term] id: GO:0030876 name: interleukin-20 receptor complex namespace: cellular_component def: "A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits." [PMID:12351624] synonym: "IL-20 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030877 name: beta-catenin destruction complex namespace: cellular_component alt_id: GO:0034742 alt_id: GO:0034747 def: "A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome." [PMID:14600025] comment: Note that the gene/protein name 'APC' should not be confused with the abbreviation for 'anaphase promoting complex'. synonym: "23S APC complex" NARROW [] synonym: "APC-Axin-1-beta-catenin complex" EXACT [] synonym: "Axin-APC-beta-catenin-GSK3B complex" EXACT [] synonym: "BDC" EXACT [GOC:bf, GOC:PARL, PMID:22899650] synonym: "beta-catenin degradation complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030878 name: thyroid gland development namespace: biological_process def: "The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone." [GOC:dgh] is_a: GO:0048732 ! gland development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0030879 name: mammary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages." [PMID:9576833] synonym: "mammogenesis" NARROW [GOC:dph] is_a: GO:0048732 ! gland development [Term] id: GO:0030880 name: RNA polymerase complex namespace: cellular_component def: "Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits." [GOC:mah] subset: goslim_pir synonym: "multisubunit RNA polymerase" EXACT [] is_a: GO:0044424 ! intracellular part is_a: GO:0061695 ! transferase complex, transferring phosphorus-containing groups [Term] id: GO:0030881 name: beta-2-microglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-2-microglobulin." [GOC:mah] subset: goslim_chembl is_a: GO:0005515 ! protein binding [Term] id: GO:0030882 name: lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid antigen." [PMID:14500461] is_a: GO:0003823 ! antigen binding is_a: GO:0008289 ! lipid binding [Term] id: GO:0030883 name: endogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endogenous cellular lipid antigen." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030884 name: exogenous lipid antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an exogenous lipid antigen (examples include microbial lipids and glycolipids)." [PMID:14500461] is_a: GO:0030882 ! lipid antigen binding [Term] id: GO:0030885 name: regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that modulates the frequency or rate of myeloid dendritic cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030886 name: negative regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation." [GOC:mah] synonym: "down regulation of myeloid dendritic cell activation" EXACT [] synonym: "down-regulation of myeloid dendritic cell activation" EXACT [] synonym: "downregulation of myeloid dendritic cell activation" EXACT [] synonym: "inhibition of myeloid dendritic cell activation" NARROW [] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation relationship: negatively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030887 name: positive regulation of myeloid dendritic cell activation namespace: biological_process def: "Any process that stimulates, induces or increases the rate of myeloid dendritic cell activation." [GOC:mah] synonym: "activation of myeloid dendritic cell activation" NARROW [] synonym: "stimulation of myeloid dendritic cell activation" NARROW [] synonym: "up regulation of myeloid dendritic cell activation" EXACT [] synonym: "up-regulation of myeloid dendritic cell activation" EXACT [] synonym: "upregulation of myeloid dendritic cell activation" EXACT [] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0030885 ! regulation of myeloid dendritic cell activation relationship: positively_regulates GO:0001773 ! myeloid dendritic cell activation [Term] id: GO:0030888 name: regulation of B cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of B cell proliferation." [GOC:mah] synonym: "regulation of B lymphocyte proliferation" EXACT [] synonym: "regulation of B-cell proliferation" EXACT [] synonym: "regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0050670 ! regulation of lymphocyte proliferation is_a: GO:0050864 ! regulation of B cell activation relationship: regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030889 name: negative regulation of B cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of B cell proliferation." [GOC:mah] synonym: "down regulation of B cell proliferation" EXACT [] synonym: "down-regulation of B cell proliferation" EXACT [] synonym: "downregulation of B cell proliferation" EXACT [] synonym: "inhibition of B cell proliferation" NARROW [] synonym: "negative regulation of B lymphocyte proliferation" EXACT [] synonym: "negative regulation of B-cell proliferation" EXACT [] synonym: "negative regulation of B-lymphocyte proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation is_a: GO:0050869 ! negative regulation of B cell activation relationship: negatively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030890 name: positive regulation of B cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of B cell proliferation." [GOC:mah] synonym: "activation of B cell proliferation" NARROW [] synonym: "positive regulation of B lymphocyte proliferation" EXACT [] synonym: "positive regulation of B-cell proliferation" EXACT [] synonym: "positive regulation of B-lymphocyte proliferation" EXACT [] synonym: "stimulation of B cell proliferation" NARROW [] synonym: "up regulation of B cell proliferation" EXACT [] synonym: "up-regulation of B cell proliferation" EXACT [] synonym: "upregulation of B cell proliferation" EXACT [] is_a: GO:0030888 ! regulation of B cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation is_a: GO:0050871 ! positive regulation of B cell activation relationship: positively_regulates GO:0042100 ! B cell proliferation [Term] id: GO:0030891 name: VCB complex namespace: cellular_component def: "A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1." [GOC:mah, PMID:11865071] synonym: "pVHL-elongin C-elongin B complex" EXACT [] synonym: "VHL complex" EXACT [] synonym: "von Hippel-Lindau tumor suppressor complex" EXACT [] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex [Term] id: GO:0030892 name: mitotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030893 name: meiotic cohesin complex namespace: cellular_component def: "A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex." [GOC:mah, PMID:12750522] is_a: GO:0008278 ! cohesin complex [Term] id: GO:0030894 name: replisome namespace: cellular_component def: "A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins." [GOC:mah, GOC:vw] subset: goslim_pir synonym: "DNA synthesome complex" RELATED [CORUM:1001] synonym: "RC complex" RELATED [CORUM:309, PMID:12006500] synonym: "replication-competent complex" RELATED [CORUM:309, PMID:12006500] xref: Wikipedia:Replisome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0030895 name: apolipoprotein B mRNA editing enzyme complex namespace: cellular_component def: "Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP)." [PMID:10781591] synonym: "apoB mRNA editing enzyme complex" EXACT [] synonym: "APOBEC" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0030896 name: checkpoint clamp complex namespace: cellular_component def: "Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage." [PMID:12531008] comment: Note that the following subunit names have been used: human RAD9/RAD1/HUS1; S. pombe Rad9/Rad1/Hus1; S. cerevisiae Ddc1p/Rad17p/Mec3p. synonym: "CCC" EXACT [] synonym: "Rad9-Hus1-Rad1 (9-1-1) clamp complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0030897 name: HOPS complex namespace: cellular_component def: "A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion." [PMID:10944212, PMID:23645161] is_a: GO:0098796 ! membrane protein complex is_a: GO:0099023 ! tethering complex [Term] id: GO:0030898 name: actin-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of an actin filament to accelerate release of ADP and phosphate." [GOC:mah] synonym: "actin-activated ATPase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030899 name: calcium-dependent ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+)." [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0030900 name: forebrain development namespace: biological_process def: "The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=forebrain] synonym: "prosencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030901 name: midbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=midbrain] synonym: "mesencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030902 name: hindbrain development namespace: biological_process def: "The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium)." [http://www2.merriam-webster.com/cgi-bin/mwmednlm?book=Medical&va=hindbrain] synonym: "rhombencephalon development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development [Term] id: GO:0030903 name: notochord development namespace: biological_process def: "The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column." [GOC:dgh] is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0030904 name: retromer complex namespace: cellular_component def: "A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35." [GOC:bf, PMID:26220253, PMID:27385586, PMID:9700157] subset: goslim_pir is_a: GO:0044464 ! cell part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0030905 name: retromer, tubulation complex namespace: cellular_component def: "The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6." [GOC:bf, PMID:26220253, PMID:9700157] synonym: "heterodimeric membrane-deforming retromer subcomplex" EXACT [GOC:bf, GOC:PARL, PMID:22193161] synonym: "retromer complex, outer shell" EXACT [] synonym: "SNX-BAR dimer" EXACT [PMID:26220253] is_a: GO:0044464 ! cell part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030906 name: retromer, cargo-selective complex namespace: cellular_component def: "The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals." [GOC:bf, PMID:11102511, PMID:26220253, PMID:9700157] synonym: "cargo-selective retromer subcomplex" EXACT [PMID:19531583, PMID:20923837] synonym: "retromer complex, inner shell" EXACT [] synonym: "retromer CSC" EXACT [GOC:bf, GOC:PARL] synonym: "retromer, cargo recognition complex" EXACT [PMID:26220253] synonym: "retromer, CRC" EXACT [GOC:bf, GOC:PARL, PMID:26220253] is_a: GO:0044464 ! cell part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030904 ! retromer complex [Term] id: GO:0030907 name: MBF transcription complex namespace: cellular_component def: "A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi4p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p." [GOC:mah, PMID:11206552, PMID:15838511, PMID:18160399, PMID:9343385] synonym: "DSC1 transcription factor complex" EXACT [] synonym: "MBF" EXACT [] synonym: "Mlu1-box binding factor" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0030908 name: protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence." [GOC:mah] xref: Wikipedia:Protein_splicing is_a: GO:0016485 ! protein processing [Term] id: GO:0030909 name: non-intein-mediated protein splicing namespace: biological_process def: "The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins." [GOC:mah] is_a: GO:0030908 ! protein splicing [Term] id: GO:0030910 name: olfactory placode formation namespace: biological_process def: "The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity." [GOC:dgh] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0043584 ! nose development relationship: part_of GO:0071699 ! olfactory placode morphogenesis [Term] id: GO:0030911 name: TPR domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices." [GOC:mah] synonym: "tetratricopeptide repeat domain binding" EXACT [GOC:sl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0030912 name: response to deep water namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle." [GOC:mah] comment: Note that this term should not be confused with 'response to flooding ; GO:0009413'; which refers to immersion in water on a shorter time scale. is_a: GO:0009415 ! response to water [Term] id: GO:0030913 name: paranodal junction assembly namespace: biological_process def: "Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier." [PMID:14715942] synonym: "paranodal axoglial junction formation" EXACT [PMID:18803321] synonym: "paranodal junction biosynthesis" EXACT [] synonym: "paranodal junction formation" EXACT [] is_a: GO:0007043 ! cell-cell junction assembly is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0032288 ! myelin assembly [Term] id: GO:0030914 name: STAGA complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The composition is similar to that of the SAGA complex; for example, the human complex contains the transcription-transformation cofactor TRRAP, hGCN5L acetylase, novel human ADA-like and SPT-like cofactors, and a subset of TAFs." [PMID:11564863] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "SPT3-TAF9-GCN5 acetylase complex" EXACT [GOC:rl, PMID:18838386] synonym: "STAGA coactivator complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0030915 name: Smc5-Smc6 complex namespace: cellular_component def: "A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans." [GOC:rb, PMID:14701739, PMID:15738391, PMID:27373152] is_a: GO:0044427 ! chromosomal part is_a: GO:0106068 ! SUMO ligase complex relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0030916 name: otic vesicle formation namespace: biological_process def: "The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear." [GOC:dgh] synonym: "otocyst biosynthesis" EXACT [] synonym: "otocyst formation" EXACT [] is_a: GO:0072175 ! epithelial tube formation relationship: part_of GO:0071600 ! otic vesicle morphogenesis [Term] id: GO:0030917 name: midbrain-hindbrain boundary development namespace: biological_process def: "The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages." [GOC:dgh] synonym: "isthmic organizer development" EXACT [] synonym: "isthmomesencephalic boundary development" EXACT [] synonym: "isthmus development" EXACT [] synonym: "MHB development" EXACT [] synonym: "midbrain-hindbrain orgainizer development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007420 ! brain development relationship: part_of GO:0021903 ! rostrocaudal neural tube patterning [Term] id: GO:0030919 name: peptidyl-serine O-acetylation namespace: biological_process def: "The acetylation of peptidyl-serine to form peptidyl-O-acetyl-L-serine." [PMID:489587, PMID:7309355, RESID:AA0364] xref: RESID:AA0364 is_a: GO:0018209 ! peptidyl-serine modification is_a: GO:0030920 ! peptidyl-serine acetylation [Term] id: GO:0030920 name: peptidyl-serine acetylation namespace: biological_process def: "The acetylation of peptidyl-serine." [GOC:mah] is_a: GO:0006473 ! protein acetylation [Term] id: GO:0030921 name: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:9631087, RESID:AA0183] xref: RESID:AA0183 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030922 name: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine namespace: biological_process def: "The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues." [PMID:12623015, RESID:AA0365] xref: RESID:AA0365 is_a: GO:0018251 ! peptidyl-tyrosine dehydrogenation [Term] id: GO:0030923 name: metal incorporation into metallo-oxygen cluster namespace: biological_process def: "The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate." [GOC:jsg] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0030924 name: manganese incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of manganese into a metallo-oxygen cluster." [GOC:jsg] is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030925 name: calcium incorporation into metallo-oxygen cluster namespace: biological_process def: "The incorporation of calcium into a metallo-oxygen cluster." [GOC:jsg] is_a: GO:0030923 ! metal incorporation into metallo-oxygen cluster [Term] id: GO:0030926 name: calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] xref: RESID:AA0366 is_a: GO:0030925 ! calcium incorporation into metallo-oxygen cluster [Term] id: GO:0030927 name: manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide namespace: biological_process def: "The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site." [PMID:14764885, RESID:AA0366] xref: RESID:AA0366 is_a: GO:0030924 ! manganese incorporation into metallo-oxygen cluster [Term] id: GO:0030929 name: ADPG pyrophosphorylase complex namespace: cellular_component def: "Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits." [GOC:tb, PMID:9680965] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0030930 name: homotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030931 name: heterotetrameric ADPG pyrophosphorylase complex namespace: cellular_component def: "A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030929 ! ADPG pyrophosphorylase complex [Term] id: GO:0030932 name: amyloplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the amyloplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0030933 name: chloroplast ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in the chloroplast." [GOC:mah] is_a: GO:0031009 ! plastid ADPG pyrophosphorylase complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0030934 name: anchoring collagen complex namespace: cellular_component def: "Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures." [ISBN:0721639976] synonym: "connecting collagen" EXACT [ISBN:0721639976] synonym: "linking collagen" EXACT [ISBN:0721639976] is_a: GO:0005581 ! collagen trimer is_a: GO:0044420 ! extracellular matrix component relationship: part_of GO:0062023 ! collagen-containing extracellular matrix [Term] id: GO:0030935 name: sheet-forming collagen trimer namespace: cellular_component def: "sheet-forming collagen trimer" [ISBN:0721639976] synonym: "hexagonal network-forming collagen" EXACT [ISBN:0815316194] is_a: GO:0098642 ! network-forming collagen trimer relationship: part_of GO:0098646 ! collagen sheet [Term] id: GO:0030936 name: transmembrane collagen trimer namespace: cellular_component def: "Any collagen trimer that passes through a lipid bilayer membrane." [ISBN:0721639976] synonym: "MACIT" EXACT [ISBN:0198599587] is_a: GO:0005581 ! collagen trimer is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030937 name: collagen type XVII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin." [ISBN:0721639976, PMID:19693541, PMID:21421911] is_a: GO:0030936 ! transmembrane collagen trimer is_a: GO:0098637 ! protein complex involved in cell-matrix adhesion is_a: GO:0098733 ! hemidesmosome associated protein complex [Term] id: GO:0030938 name: collagen type XVIII trimer namespace: cellular_component def: "A collagen homotrimer of alpha1(XVIII) chains." [ISBN:0721639976, PMID:21421911] is_a: GO:0098651 ! basement membrane collagen trimer [Term] id: GO:0030939 name: obsolete response to long-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the light phase being longer than the dark." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. synonym: "response to long-day photoperiod" EXACT [] is_obsolete: true consider: GO:0048571 [Term] id: GO:0030940 name: obsolete response to short-day photoperiod namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a photoperiod, an intermittent cycle of light (day) and dark (night) photoperiod regimes, with the dark phase being longer than the light." [GOC:pj] comment: This term was made obsolete because it was wrongly defined. synonym: "response to short-day photoperiod" EXACT [] is_obsolete: true consider: GO:0048572 [Term] id: GO:0030941 name: chloroplast targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030942 name: endoplasmic reticulum signal peptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum." [GOC:mah] synonym: "ER signal peptide binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030943 name: mitochondrion targeting sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion." [GOC:mah] synonym: "mitochondrial targeting sequence binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0030944 name: DDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:mah] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0030945 name: protein tyrosine phosphatase activity, via thiol-phosphate intermediate namespace: molecular_function def: "The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate." [GOC:hjd] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030946 name: protein tyrosine phosphatase activity, metal-dependent namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions." [GOC:mah] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0030947 name: regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "regulation of VEGF receptor signaling pathway" EXACT [] synonym: "regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus relationship: regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030948 name: negative regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "down regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "down-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "downregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "inhibition of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "negative regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signaling pathway" EXACT [] synonym: "negative regulation of VEGF receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus relationship: negatively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030949 name: positive regulation of vascular endothelial growth factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity." [GOC:dgh] synonym: "activation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "positive regulation of vascular endothelial growth factor receptor signalling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signaling pathway" EXACT [] synonym: "positive regulation of VEGF receptor signalling pathway" EXACT [] synonym: "stimulation of vascular endothelial growth factor receptor signaling pathway" NARROW [] synonym: "up regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "up-regulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] synonym: "upregulation of vascular endothelial growth factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0030947 ! regulation of vascular endothelial growth factor receptor signaling pathway relationship: positively_regulates GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0030950 name: establishment or maintenance of actin cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures." [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030951 name: establishment or maintenance of microtubule cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity [Term] id: GO:0030952 name: establishment or maintenance of cytoskeleton polarity namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures." [GOC:mah] synonym: "cytoskeleton polarization" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0030953 name: astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles." [GOC:mah] synonym: "astral microtubule organisation" EXACT [GOC:curators] synonym: "astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0031122 ! cytoplasmic microtubule organization [Term] id: GO:0030954 name: astral microtubule nucleation namespace: biological_process def: "The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule." [GOC:mah] is_a: GO:0030953 ! astral microtubule organization is_a: GO:0051418 ! microtubule nucleation by microtubule organizing center [Term] id: GO:0030955 name: potassium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with potassium (K+) ions." [GOC:mah] is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0030956 name: glutamyl-tRNA(Gln) amidotransferase complex namespace: cellular_component def: "A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms." [GOC:mlg] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity ; GO:0050567'. synonym: "AdT" RELATED [GOC:rb] synonym: "GatCAB" NARROW [GOC:rb] synonym: "GatFAB" NARROW [GOC:rb] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0030957 name: Tat protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus." [GOC:mah, PMID:9094689] is_a: GO:0061629 ! RNA polymerase II-specific DNA-binding transcription factor binding [Term] id: GO:0030958 name: RITS complex namespace: cellular_component def: "A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing." [PMID:14704433] is_a: GO:0031332 ! RNAi effector complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0005720 ! nuclear heterochromatin [Term] id: GO:0030959 name: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link." [RESID:AA0367] xref: RESID:AA0367 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030960 name: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine namespace: biological_process def: "The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link." [PDB:1NGK, PMID:12719529, RESID:AA0368] xref: RESID:AA0368 is_a: GO:0018149 ! peptide cross-linking is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0030961 name: peptidyl-arginine hydroxylation namespace: biological_process def: "The hydroxylation of peptidyl-arginine to form peptidyl-hydroxyarginine." [GOC:mah] is_a: GO:0018195 ! peptidyl-arginine modification [Term] id: GO:0030962 name: peptidyl-arginine dihydroxylation to peptidyl-3,4-dihydroxy-L-arginine namespace: biological_process def: "The dihydroxylation of peptidyl-arginine to form peptidyl-3,4-dihydroxy-L-arginine." [PMID:10978343, RESID:AA0369] xref: RESID:AA0369 is_a: GO:0030961 ! peptidyl-arginine hydroxylation [Term] id: GO:0030963 name: peptidyl-lysine dihydroxylation to 4,5-dihydroxy-L-lysine namespace: biological_process def: "The dihydroxylation of peptidyl-lysine to peptidyl-4,5-dihydroxy-L-lysine." [PMID:10978343, RESID:AA0370] xref: RESID:AA0370 is_a: GO:0017185 ! peptidyl-lysine hydroxylation [Term] id: GO:0030964 name: NADH dehydrogenase complex namespace: cellular_component alt_id: GO:0030025 alt_id: GO:0030966 alt_id: GO:0031675 alt_id: GO:0031677 alt_id: GO:0031678 alt_id: GO:0045280 def: "An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone." [GOC:mah] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function possessed by this complex is represented by the molecular function term 'NADH dehydrogenase (quinone) activity ; GO:0050136'. subset: goslim_pir synonym: "Complex I" EXACT [] synonym: "NADH dehydrogenase complex (plastoquinone)" NARROW [] synonym: "NADH dehydrogenase complex (quinone)" NARROW [] synonym: "NADH dehydrogenase complex (ubiquinone)" NARROW [] synonym: "NADH:plastoquinone reductase complex" NARROW [] synonym: "plastid NADH dehydrogenase complex (plastoquinone)" NARROW [] xref: Wikipedia:NADH_dehydrogenase is_a: GO:0098796 ! membrane protein complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0030965 name: plasma membrane electron transport, NADH to quinone namespace: biological_process def: "The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase." [GOC:mah, GOC:sd] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042774 ! plasma membrane ATP synthesis coupled electron transport [Term] id: GO:0030968 name: endoplasmic reticulum unfolded protein response namespace: biological_process def: "The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation." [GOC:mah, PMID:12042763] comment: Note that this term should not be confused with 'response to unfolded protein ; GO:0006986', which refers to any response to the presence of unfolded proteins anywhere in the cell or in multicellular organism. Also see 'ER-associated protein catabolic process ; GO:0030433'. synonym: "ER unfolded protein response" EXACT [] synonym: "erUPR" EXACT [] synonym: "SREBP-mediated signalling pathway" RELATED [] is_a: GO:0007165 ! signal transduction is_a: GO:0034976 ! response to endoplasmic reticulum stress relationship: part_of GO:0034620 ! cellular response to unfolded protein [Term] id: GO:0030969 name: obsolete mRNA splicing via endonucleolytic cleavage and ligation involved in unfolded protein response namespace: biological_process def: "OBSOLETE. The spliceosome-independent cleavage and ligation of the mRNA encoding a UFP-specific transcription factor to remove a single intron, thereby increasing both the translational efficiency of the processed mRNA and the activity of the protein it encodes." [GOC:mah, PMID:12042763, PMID:21924241] comment: The reason for obsoletion is that this process represent a single step (molecular function) of the IRE1-mediated unfolded protein response (GO:0036498). synonym: "HAC1 mRNA splicing" NARROW [PMID:21924241] synonym: "IRE1-mediated XBP-1 mRNA splicing" NARROW [GOC:bf] synonym: "Ire1p-mediated HAC-1 mRNA splicing" NARROW [GOC:bf] synonym: "non-spliceosomal mRNA splicing in the unfolded protein response pathway" EXACT [PMID:10357823] synonym: "spliceosome-independent UFP-specific transcription factor mRNA processing" EXACT [GOC:dph] synonym: "UFP-specific transcription factor mRNA processing during unfolded protein response" RELATED [GOC:dph, GOC:tb] synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum unfolded protein response" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in endoplasmic reticulum UPR" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in ER unfolded protein response" EXACT [GOC:bf] synonym: "UFP-specific transcription factor mRNA processing involved in ER UPR" EXACT [GOC:bf] synonym: "unconventional mRNA splicing involved in UPR" EXACT [GOC:bf] synonym: "unconventional splicing of XBP1 mRNA" EXACT [PMID:11779464, PMID:26068456] synonym: "unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor" RELATED [] synonym: "unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase" RELATED [] synonym: "XBP1 mRNA splicing" EXACT [PMID:11779464, PMID:25968568] synonym: "XBP1 mRNA splicing under conditions of endoplasmic reticulum (ER) stress" NARROW [PMID:21924241] synonym: "XBP1 mRNA splicing, via endonucleolytic cleavage and ligation" EXACT [GOC:bf] is_obsolete: true consider: GO:0036498 [Term] id: GO:0030970 name: retrograde protein transport, ER to cytosol namespace: biological_process def: "The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon." [PMID:11994744] synonym: "protein dislocation from ER" EXACT [GOC:dph, GOC:krc] synonym: "protein retrotranslocation, ER to cytosol" EXACT [GOC:bf] synonym: "retrograde protein transport, endoplasmic reticulum to cytosol" EXACT [] is_a: GO:0032527 ! protein exit from endoplasmic reticulum is_a: GO:1903513 ! endoplasmic reticulum to cytosol transport relationship: part_of GO:0036503 ! ERAD pathway [Term] id: GO:0030971 name: receptor tyrosine kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor that possesses protein tyrosine kinase activity." [GOC:mah] synonym: "transmembrane receptor protein tyrosine kinase ligand binding" RELATED [] is_a: GO:0005102 ! signaling receptor binding is_a: GO:1990782 ! protein tyrosine kinase binding [Term] id: GO:0030972 name: obsolete cleavage of cytosolic proteins involved in execution phase of apoptosis namespace: biological_process def: "OBSOLETE. The proteolytic degradation of proteins in the cytosol that contributes to apoptosis." [GOC:dph, GOC:mah, GOC:mtg_apoptosis, GOC:tb, ISBN:0815332181] comment: This term was obsoleted because it refers to targets of effector proteins (caspases); the 'cleavage' process referred to in the term name is in fact the same molecular function represented by GO:0097200 'cysteine-type endopeptidase activity involved in execution phase of apoptosis'. synonym: "apoptotic cleavage of cytosolic proteins" EXACT [] synonym: "cleavage of cytosolic proteins involved in apoptosis" BROAD [] synonym: "cleavage of cytosolic proteins involved in execution phase of apoptosis" EXACT [] is_obsolete: true consider: GO:0097200 [Term] id: GO:0030973 name: molybdate ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with molybdate (MoO4 2-) ions." [GOC:mlg] is_a: GO:0043168 ! anion binding [Term] id: GO:0030974 name: thiamine pyrophosphate transmembrane transport namespace: biological_process def: "The process in which thiamine pyrophosphate is transported across a membrane." [GOC:mlg] synonym: "thiamin diphosphate transport" EXACT [] synonym: "thiamin pyrophosphate transport" EXACT [GOC:curators] synonym: "thiamine diphosphate transport" EXACT [] synonym: "thiamine pyrophosphate transport" NARROW [] synonym: "TPP transport" EXACT [] is_a: GO:0015695 ! organic cation transport is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0045117 ! azole transport is_a: GO:0051181 ! cofactor transport is_a: GO:0072348 ! sulfur compound transport is_a: GO:0072531 ! pyrimidine-containing compound transmembrane transport is_a: GO:0098655 ! cation transmembrane transport is_a: GO:0098656 ! anion transmembrane transport [Term] id: GO:0030975 name: thiamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:mlg] synonym: "thiamin binding" EXACT [GOC:curators] synonym: "vitamin B1 binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0030976 name: thiamine pyrophosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases." [CHEBI:45931, GOC:mlg] synonym: "aneurine pyrophosphate binding" EXACT [] synonym: "cocarboxylase binding" EXACT [] synonym: "diphosphothiamin binding" EXACT [] synonym: "thiamin pyrophosphate binding" EXACT [GOC:curators] synonym: "TPP binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0043168 ! anion binding is_a: GO:0043169 ! cation binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0030977 name: taurine binding namespace: molecular_function def: "Interacting selectively and non-covalently with taurine." [GOC:mlg] is_a: GO:0043210 ! alkanesulfonate binding [Term] id: GO:0030978 name: alpha-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] synonym: "alpha-glucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0030979 name: alpha-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds." [GOC:mah] synonym: "alpha-glucan anabolism" EXACT [] synonym: "alpha-glucan biosynthesis" EXACT [] synonym: "alpha-glucan formation" EXACT [] synonym: "alpha-glucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process is_a: GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0030980 name: alpha-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alpha-glucans." [GOC:mah] synonym: "alpha-glucan breakdown" EXACT [] synonym: "alpha-glucan catabolism" EXACT [] synonym: "alpha-glucan degradation" EXACT [] is_a: GO:0009251 ! glucan catabolic process is_a: GO:0030978 ! alpha-glucan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0030981 name: cortical microtubule cytoskeleton namespace: cellular_component def: "The portion of the microtubule cytoskeleton that lies just beneath the plasma membrane." [GOC:mah] is_a: GO:0030863 ! cortical cytoskeleton is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0030982 name: adventurous gliding motility namespace: biological_process def: "A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime." [GOC:mlg, PMID:11967173] synonym: "adventurous gliding movement" EXACT [] is_a: GO:0071976 ! cell gliding [Term] id: GO:0030983 name: mismatched DNA binding namespace: molecular_function alt_id: GO:0032134 def: "Interacting selectively and non-covalently with double-stranded DNA containing one or more mismatches." [GOC:mah] synonym: "mispair binding" EXACT [] synonym: "mispaired DNA binding" EXACT [] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0030984 name: kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen, any of a group of plasma proteins that are kinin precursors." [GOC:mah, PMID:9520414] is_a: GO:0005515 ! protein binding [Term] id: GO:0030985 name: high molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of high molecular mass." [GOC:mah, PMID:9520414] synonym: "HK binding" EXACT [] synonym: "HMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030986 name: low molecular weight kininogen binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kininogen of low molecular mass." [GOC:mah, PMID:9520414] synonym: "LK binding" EXACT [] synonym: "LMW kininogen binding" EXACT [] is_a: GO:0030984 ! kininogen binding [Term] id: GO:0030987 name: high molecular weight kininogen receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a high molecular weight kininogen receptor." [GOC:mah] is_a: GO:0005102 ! signaling receptor binding [Term] id: GO:0030988 name: high molecular weight kininogen receptor complex namespace: cellular_component def: "A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins." [GOC:mah, PMID:11290596] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0030989 name: dynein-driven meiotic oscillatory nuclear movement namespace: biological_process def: "Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein." [GOC:vw, PMID:16111942, PMID:9572142] comment: Dynein-driven meiotic oscillatory nuclear movement precedes meiotic recombination. synonym: "HNM" EXACT [] synonym: "horsetail movement" EXACT [] synonym: "horsetail nuclear movement" EXACT [GOC:vw] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0030990 name: intraciliary transport particle namespace: cellular_component def: "A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:22118932, PMID:23945166] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. subset: goslim_pir synonym: "IFT complex" RELATED [] synonym: "intraflagellar transport complex" EXACT [] synonym: "intraflagellar transport particle" EXACT [] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0030991 name: intraciliary transport particle A namespace: cellular_component def: "The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa." [GOC:cilia, GOC:kmv, PMID:14570576] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. synonym: "IFT A complex" RELATED [] synonym: "IFT complex A" RELATED [] synonym: "intraflagellar transport complex A" EXACT [] synonym: "intraflagellar transport particle A" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030990 ! intraciliary transport particle [Term] id: GO:0030992 name: intraciliary transport particle B namespace: cellular_component def: "The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa." [GOC:cilia, GOC:kmv, PMID:14570576, PMID:19253336] comment: Note that we deem cilia and microtubule-based flagella to be equivalent. synonym: "IFT B complex" RELATED [] synonym: "IFT complex B" RELATED [] synonym: "intraflagellar transport complex B" EXACT [] synonym: "intraflagellar transport particle B" EXACT [] is_a: GO:0032991 ! protein-containing complex relationship: part_of GO:0030990 ! intraciliary transport particle [Term] id: GO:0030993 name: axonemal heterotrimeric kinesin-II complex namespace: cellular_component def: "A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme." [GOC:kmv, PMID:14570576] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0030994 name: primary cell septum disassembly namespace: biological_process def: "Dissolution of the primary septum during cell separation." [PMID:12665550] synonym: "hydrolysis of primary cell septum" EXACT [] synonym: "primary cell septum hydrolysis" EXACT [] synonym: "primary septum hydrolysis" BROAD [] is_a: GO:0022411 ! cellular component disassembly relationship: part_of GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0030995 name: cell septum edging catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation." [GOC:mah, PMID:15194814] synonym: "cell septum edging hydrolysis" EXACT [] synonym: "hydrolysis of cell septum edging" EXACT [] synonym: "hydrolysis of edging of cell septum" EXACT [] synonym: "septum edging hydrolysis" BROAD [] is_a: GO:0071999 ! extracellular polysaccharide catabolic process relationship: part_of GO:0000920 ! septum digestion after cytokinesis [Term] id: GO:0030996 name: obsolete mitotic cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "OBSOLETE. The process in which the mitotic cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of deprivation of nitrogen." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] comment: This term was made obsolete because it is superfluous, as only the more specific 'mitotic G1 cell cycle arrest in response to nitrogen starvation' has been observed. synonym: "cell cycle arrest in response to nitrogen starvation" BROAD [] is_obsolete: true [Term] id: GO:0030997 name: regulation of centriole-centriole cohesion namespace: biological_process def: "Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker." [PMID:11076968] is_a: GO:0046605 ! regulation of centrosome cycle relationship: part_of GO:0007098 ! centrosome cycle relationship: regulates GO:0010457 ! centriole-centriole cohesion [Term] id: GO:0030998 name: linear element namespace: cellular_component def: "A proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase. Linear elements have a structure related to but not equivalent to the synaptonemal complex." [DOI:10.2323/jgam.28.263, GOC:jb, PMID:12665553] is_a: GO:0099086 ! synaptonemal structure [Term] id: GO:0030999 name: linear element assembly namespace: biological_process def: "The cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase." [GOC:jb, GOC:mah] synonym: "linear element formation" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0031000 name: response to caffeine namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them." [CHEBI:27732, GOC:ef, GOC:mah] is_a: GO:0009410 ! response to xenobiotic stimulus is_a: GO:0014074 ! response to purine-containing compound is_a: GO:0036270 ! response to diuretic is_a: GO:0043279 ! response to alkaloid [Term] id: GO:0031001 name: response to brefeldin A namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus." [GOC:mah] is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0046677 ! response to antibiotic is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0031002 name: actin rod namespace: cellular_component def: "A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions." [GOC:kp, GOC:krc, PMID:11858703, PMID:19459188, PMID:22623727, PMID:24813767, PMID:27535426, PMID:7820870] is_a: GO:0032432 ! actin filament bundle [Term] id: GO:0031003 name: actin tubule namespace: cellular_component def: "A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together." [GOC:kp] is_a: GO:0032432 ! actin filament bundle relationship: part_of GO:0031002 ! actin rod [Term] id: GO:0031004 name: potassium ion-transporting ATPase complex namespace: cellular_component def: "Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex." [PMID:10608856, PMID:9858692, TIGR_TIGRFAMS:TIGR01497] synonym: "Kdp system complex" EXACT [] is_a: GO:0090533 ! cation-transporting ATPase complex [Term] id: GO:0031005 name: filamin binding namespace: molecular_function alt_id: GO:0031006 alt_id: GO:0031007 alt_id: GO:0031008 def: "Interacting selectively and non-covalently with a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain." [GOC:mah, PMID:11336782] synonym: "ABP-278/276 binding" NARROW [] synonym: "ABP-280 binding" NARROW [] synonym: "ABPL binding" NARROW [] synonym: "alpha-filamin binding" NARROW [] synonym: "beta-filamin binding" NARROW [] synonym: "filamin A binding" NARROW [] synonym: "filamin B binding" NARROW [] synonym: "filamin C binding" EXACT [] synonym: "filamin-1 binding" NARROW [] synonym: "filamin-2 binding" NARROW [] synonym: "filamin-3 binding" NARROW [] synonym: "filamin-A binding" NARROW [] synonym: "filamin-B binding" EXACT [] synonym: "filamin-C binding" NARROW [] synonym: "gamma-filamin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031009 name: plastid ADPG pyrophosphorylase complex namespace: cellular_component def: "An ADPG pyrophosphorylase complex found in a plastid." [GOC:mah] is_a: GO:0030931 ! heterotetrameric ADPG pyrophosphorylase complex is_a: GO:0044435 ! plastid part [Term] id: GO:0031010 name: ISWI-type complex namespace: cellular_component def: "Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair." [GOC:krc, GOC:mah, PMID:15020051, PMID:15284901, PMID:16568949, PMID:21810179] is_a: GO:0070603 ! SWI/SNF superfamily-type complex [Term] id: GO:0031011 name: Ino80 complex namespace: cellular_component def: "A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity and 3' to 5' DNA helicase activity." [GOC:jh, GOC:rb, PMID:19355820] synonym: "INO80 chromatin remodeling complex" EXACT [] is_a: GO:0033202 ! DNA helicase complex is_a: GO:0097346 ! INO80-type complex [Term] id: GO:0031012 name: extracellular matrix namespace: cellular_component alt_id: GO:0005578 def: "A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues." [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "proteinaceous extracellular matrix" EXACT [] xref: NIF_Subcellular:nlx_subcell_20090513 xref: Wikipedia:Extracellular_matrix is_a: GO:0044421 ! extracellular region part [Term] id: GO:0031013 name: troponin I binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin I, the inhibitory subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031014 name: troponin T binding namespace: molecular_function def: "Interacting selectively and non-covalently with troponin T, the tropomyosin-binding subunit of the troponin complex." [GOC:mah, ISBN:0815316194] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031015 name: obsolete karyopherin docking complex namespace: cellular_component def: "OBSOLETE. A subcomplex of the nuclear pore complex that interacts with karyopherin-cargo complexes; a well-characterized example in Saccharomyces contains Asm4p, Nup53p, and Nup170p." [PMID:11867631, PMID:9864357] synonym: "Asm4p-containing complex" NARROW [] synonym: "karyopherin docking complex" EXACT [] synonym: "nuclear pore subcomplex" BROAD [] is_obsolete: true consider: GO:0017056 consider: GO:0044613 [Term] id: GO:0031016 name: pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes." [GOC:cvs] xref: Wikipedia:Pancreas is_a: GO:0048513 ! animal organ development [Term] id: GO:0031017 name: exocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells." [GOC:cvs] is_a: GO:0048732 ! gland development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035272 ! exocrine system development relationship: part_of GO:0055123 ! digestive system development [Term] id: GO:0031018 name: endocrine pancreas development namespace: biological_process def: "The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin." [GOC:cvs] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0031016 ! pancreas development relationship: part_of GO:0035270 ! endocrine system development [Term] id: GO:0031019 name: mitochondrial mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates." [GOC:mah, PMID:12139607] synonym: "mitochondrial editosome" EXACT [] is_a: GO:0045293 ! mRNA editing complex is_a: GO:0098798 ! mitochondrial protein complex [Term] id: GO:0031020 name: plastid mRNA editing complex namespace: cellular_component def: "An mRNA editing complex found in a plastid." [GOC:mah] synonym: "plastid editosome" EXACT [] is_a: GO:0044435 ! plastid part is_a: GO:0045293 ! mRNA editing complex [Term] id: GO:0031021 name: interphase microtubule organizing center namespace: cellular_component def: "A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus." [PMID:15068790] synonym: "iMTOC" EXACT [] synonym: "interphase microtubule organising center" EXACT [] synonym: "interphase MTOC" EXACT [] is_a: GO:0005815 ! microtubule organizing center [Term] id: GO:0031022 name: nuclear migration along microfilament namespace: biological_process def: "The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins." [GOC:mah] synonym: "nuclear migration, microfilament-mediated" EXACT [] is_a: GO:0007097 ! nuclear migration is_a: GO:0030048 ! actin filament-based movement is_a: GO:0099515 ! actin filament-based transport [Term] id: GO:0031023 name: microtubule organizing center organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "microtubule organising center organisation" EXACT [GOC:curators] synonym: "microtubule organizing center organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007017 ! microtubule-based process is_a: GO:0016043 ! cellular component organization relationship: part_of GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031024 name: interphase microtubule organizing center assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center." [GOC:mah, PMID:15068790] synonym: "interphase microtubule organising center biosynthesis" EXACT [] synonym: "interphase microtubule organising center formation" EXACT [] synonym: "interphase microtubule organizing center biogenesis" RELATED [GOC:mah] synonym: "interphase microtubule organizing centre assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031023 ! microtubule organizing center organization [Term] id: GO:0031025 name: equatorial microtubule organizing center disassembly namespace: biological_process def: "The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis." [GOC:mah, PMID:15068790] synonym: "equatorial microtubule organising center disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0031121 ! equatorial microtubule organization [Term] id: GO:0031026 name: glutamate synthase complex namespace: cellular_component def: "A complex that possesses glutamate synthase activity." [GOC:mah] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0031027 name: glutamate synthase complex (NADH) namespace: cellular_component def: "A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity." [GOC:jl, PMID:7047525] is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0031028 name: septation initiation signaling namespace: biological_process def: "The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis." [GOC:mah, GOC:vw, PMID:16775007] synonym: "septation initiation network" EXACT [] synonym: "septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "septation initiation signalling" EXACT [] synonym: "SIN" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0007265 ! Ras protein signal transduction is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction is_a: GO:1901893 ! positive regulation of cell septum assembly is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process [Term] id: GO:0031029 name: regulation of septation initiation signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "regulation of septation initiation network" EXACT [] synonym: "regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "regulation of septation initiation signalling" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0031991 ! regulation of actomyosin contractile ring contraction is_a: GO:0046578 ! regulation of Ras protein signal transduction is_a: GO:1901891 ! regulation of cell septum assembly is_a: GO:1903436 ! regulation of mitotic cytokinetic process relationship: regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031030 name: negative regulation of septation initiation signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "down regulation of septation initiation signaling" EXACT [] synonym: "down-regulation of septation initiation signaling" EXACT [] synonym: "downregulation of septation initiation signaling" EXACT [] synonym: "inhibition of septation initiation signaling" NARROW [] synonym: "negative regulation of septation initiation network" EXACT [] synonym: "negative regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of septation initiation signalling" EXACT [] is_a: GO:0010974 ! negative regulation of division septum assembly is_a: GO:0031029 ! regulation of septation initiation signaling is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031031 name: positive regulation of septation initiation signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of septation initiation signaling." [GOC:mah] synonym: "activation of septation initiation signaling" NARROW [] synonym: "positive regulation of septation initiation network" EXACT [] synonym: "positive regulation of septation initiation signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of septation initiation signalling" EXACT [] synonym: "stimulation of septation initiation signaling" NARROW [] synonym: "up regulation of septation initiation signaling" EXACT [] synonym: "up-regulation of septation initiation signaling" EXACT [] synonym: "upregulation of septation initiation signaling" EXACT [] is_a: GO:0010973 ! positive regulation of division septum assembly is_a: GO:0031029 ! regulation of septation initiation signaling is_a: GO:0046579 ! positive regulation of Ras protein signal transduction is_a: GO:1903438 ! positive regulation of mitotic cytokinetic process relationship: positively_regulates GO:0031028 ! septation initiation signaling [Term] id: GO:0031032 name: actomyosin structure organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments." [GOC:dph, GOC:jl, GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins. synonym: "actomyosin organization" EXACT [] synonym: "actomyosin structure organisation" EXACT [GOC:curators] synonym: "actomyosin structure organization and biogenesis" RELATED [GOC:mah] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031033 name: myosin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules." [GOC:mah] comment: Note that this term is a child of 'actin cytoskeleton organization and biogenesis ; GO:0030036' because the actin cytoskeleton is defined as actin filaments and associated proteins; myosin structures are sufficiently closely associated with actin filaments to be included with the actin cytoskeleton. synonym: "myosin filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin filament organisation" EXACT [GOC:mah] synonym: "myosin polymerization or depolymerization" RELATED [] is_a: GO:0030036 ! actin cytoskeleton organization is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0031034 name: myosin filament assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin polymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0034622 ! cellular protein-containing complex assembly [Term] id: GO:0031035 name: myosin filament disassembly namespace: biological_process def: "The disassembly of a filament composed of myosin molecules." [GOC:mah] synonym: "myosin depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization is_a: GO:0043624 ! cellular protein complex disassembly [Term] id: GO:0031036 name: myosin II filament assembly namespace: biological_process def: "The formation of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II polymerization" RELATED [] is_a: GO:0031034 ! myosin filament assembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031037 name: myosin II filament disassembly namespace: biological_process def: "The disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II depolymerization" RELATED [] is_a: GO:0031035 ! myosin filament disassembly is_a: GO:0031038 ! myosin II filament organization [Term] id: GO:0031038 name: myosin II filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules." [GOC:mah] synonym: "myosin II filament assembly or disassembly" RELATED [GOC:mah] synonym: "myosin II filament organisation" EXACT [GOC:mah] synonym: "myosin II polymerization or depolymerization" RELATED [] is_a: GO:0031033 ! myosin filament organization [Term] id: GO:0031039 name: macronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell." [GOC:ns] xref: Wikipedia:Macronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031040 name: micronucleus namespace: cellular_component def: "A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell." [GOC:ns] xref: Wikipedia:Micronucleus is_a: GO:0005634 ! nucleus [Term] id: GO:0031041 name: O-glycan processing, core 5 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031042 name: O-glycan processing, core 6 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031043 name: O-glycan processing, core 7 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031044 name: O-glycan processing, core 8 namespace: biological_process def: "The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc." [GOC:mah, GOC:pr, PMID:10580130] is_a: GO:0016266 ! O-glycan processing [Term] id: GO:0031045 name: dense core granule namespace: cellular_component def: "Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted." [NIF_Subcellular:sao772007592, PMID:14690495] synonym: "dense core vesicle" EXACT syngo_official_label [GOC:kmv] xref: NIF_Subcellular:sao772007592 is_a: GO:0030141 ! secretory granule [Term] id: GO:0031047 name: gene silencing by RNA namespace: biological_process def: "Any process in which RNA molecules inactivate expression of target genes." [GOC:dph, GOC:mah, GOC:tb, PMID:15020054] synonym: "RNA-mediated gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016458 ! gene silencing [Term] id: GO:0031048 name: chromatin silencing by small RNA namespace: biological_process def: "Repression of transcription by conversion of large regions of DNA into heterochromatin, directed by small RNAs sharing sequence identity to the repressed region." [GOC:dph, GOC:mtg_lung, GOC:ns] synonym: "RNA interference-like chromatin silencing" EXACT [] synonym: "RNA-mediated chromatin silencing" EXACT [GOC:dph, GOC:tb] synonym: "RNA-mediated TGS" BROAD [] synonym: "RNA-mediated transcriptional silencing" EXACT [] synonym: "RNAi-directed chromatin silencing" EXACT [GOC:vw] synonym: "RNAi-like chromatin silencing" EXACT [] synonym: "small RNA-mediated heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0031047 ! gene silencing by RNA [Term] id: GO:0031049 name: programmed DNA elimination namespace: biological_process def: "The DNA metabolic process in which micronuclear-limited sequences, internal eliminated sequences (IES) and breakage eliminated sequences (BES) are removed from the developing macronucleus (anlage) of a ciliate." [GOC:mah, GOC:ns] subset: goslim_pir is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0031050 name: dsRNA processing namespace: biological_process def: "Cleavage of double-stranded RNA molecules by an RNaseIII-family enzyme to produce small RNAs (generally 20-30 nucleotides, depending on species) with biological function." [GOC:ns] synonym: "double-stranded RNA fragmentation" RELATED [] synonym: "dsRNA fragmentation" RELATED [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031051 name: scnRNA processing namespace: biological_process def: "Cleavage of noncoding, double-stranded RNAs transcribed from the micronuclear genome to produce scnRNAs, small RNAs (~28 nucleotides) that direct the deletion of micronuclear-limited sequences from the developing macronuclear genome." [PMID:15196465] synonym: "scnRNA production" BROAD [] is_a: GO:0031050 ! dsRNA processing relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031052 name: chromosome breakage namespace: biological_process def: "Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage." [GOC:ns] comment: Note that this term refers to breakage of chromosomes during normal DNA rearrangements characteristic of ciliates; it is not to be used for DNA damage or other abnormal occurrences. synonym: "establishment or maintenance of heterochromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0031049 ! programmed DNA elimination [Term] id: GO:0031053 name: primary miRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary microRNA transcript into a pre-microRNA molecule." [GOC:sl, PMID:15211354] synonym: "pri-miRNA processing" EXACT [] synonym: "primary microRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031054 name: pre-miRNA processing namespace: biological_process def: "Any process involved in the conversion of a pre-microRNA transcript into a mature microRNA molecule." [GOC:sl, PMID:15211354] synonym: "pre-microRNA processing" EXACT [] is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0035196 ! production of miRNAs involved in gene silencing by miRNA [Term] id: GO:0031055 name: chromatin remodeling at centromere namespace: biological_process def: "Dynamic structural changes in centromeric DNA." [GOC:mah] is_a: GO:0006338 ! chromatin remodeling [Term] id: GO:0031056 name: regulation of histone modification namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:1902275 ! regulation of chromatin organization relationship: regulates GO:0016570 ! histone modification [Term] id: GO:0031057 name: negative regulation of histone modification namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "down regulation of histone modification" EXACT [] synonym: "down-regulation of histone modification" EXACT [] synonym: "downregulation of histone modification" EXACT [] synonym: "inhibition of histone modification" NARROW [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:1905268 ! negative regulation of chromatin organization relationship: negatively_regulates GO:0016570 ! histone modification [Term] id: GO:0031058 name: positive regulation of histone modification namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone." [GOC:mah] synonym: "activation of histone modification" NARROW [] synonym: "stimulation of histone modification" NARROW [] synonym: "up regulation of histone modification" EXACT [] synonym: "up-regulation of histone modification" EXACT [] synonym: "upregulation of histone modification" EXACT [] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:1905269 ! positive regulation of chromatin organization relationship: positively_regulates GO:0016570 ! histone modification [Term] id: GO:0031059 name: histone deacetylation at centromere namespace: biological_process def: "The removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0016575 ! histone deacetylation [Term] id: GO:0031060 name: regulation of histone methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification relationship: regulates GO:0016571 ! histone methylation [Term] id: GO:0031061 name: negative regulation of histone methylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "down regulation of histone methylation" EXACT [] synonym: "down-regulation of histone methylation" EXACT [] synonym: "downregulation of histone methylation" EXACT [] synonym: "inhibition of histone methylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation relationship: negatively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031062 name: positive regulation of histone methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones." [GOC:mah] synonym: "activation of histone methylation" NARROW [] synonym: "stimulation of histone methylation" NARROW [] synonym: "up regulation of histone methylation" EXACT [] synonym: "up-regulation of histone methylation" EXACT [] synonym: "upregulation of histone methylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031060 ! regulation of histone methylation relationship: positively_regulates GO:0016571 ! histone methylation [Term] id: GO:0031063 name: regulation of histone deacetylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] is_a: GO:0031056 ! regulation of histone modification is_a: GO:0090311 ! regulation of protein deacetylation relationship: regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031064 name: negative regulation of histone deacetylation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "down regulation of histone deacetylation" EXACT [] synonym: "down-regulation of histone deacetylation" EXACT [] synonym: "downregulation of histone deacetylation" EXACT [] synonym: "inhibition of histone deacetylation" NARROW [] is_a: GO:0031057 ! negative regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation relationship: negatively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031065 name: positive regulation of histone deacetylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones." [GOC:mah] synonym: "activation of histone deacetylation" NARROW [] synonym: "stimulation of histone deacetylation" NARROW [] synonym: "up regulation of histone deacetylation" EXACT [] synonym: "up-regulation of histone deacetylation" EXACT [] synonym: "upregulation of histone deacetylation" EXACT [] is_a: GO:0031058 ! positive regulation of histone modification is_a: GO:0031063 ! regulation of histone deacetylation is_a: GO:0090312 ! positive regulation of protein deacetylation relationship: positively_regulates GO:0016575 ! histone deacetylation [Term] id: GO:0031066 name: regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] is_a: GO:0031063 ! regulation of histone deacetylation relationship: regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031067 name: negative regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA." [GOC:mah] synonym: "down regulation of histone deacetylation at centromere" EXACT [] synonym: "down-regulation of histone deacetylation at centromere" EXACT [] synonym: "downregulation of histone deacetylation at centromere" EXACT [] synonym: "inhibition of histone deacetylation at centromere" NARROW [] is_a: GO:0031064 ! negative regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere relationship: negatively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031068 name: positive regulation of histone deacetylation at centromere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA." [GOC:mah] synonym: "activation of histone deacetylation at centromere" NARROW [] synonym: "stimulation of histone deacetylation at centromere" NARROW [] synonym: "up regulation of histone deacetylation at centromere" EXACT [] synonym: "up-regulation of histone deacetylation at centromere" EXACT [] synonym: "upregulation of histone deacetylation at centromere" EXACT [] is_a: GO:0031065 ! positive regulation of histone deacetylation is_a: GO:0031066 ! regulation of histone deacetylation at centromere relationship: positively_regulates GO:0031059 ! histone deacetylation at centromere [Term] id: GO:0031069 name: hair follicle morphogenesis namespace: biological_process def: "The process in which the anatomical structures of the hair follicle are generated and organized." [GOC:ln] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0022405 ! hair cycle process relationship: part_of GO:0001942 ! hair follicle development relationship: part_of GO:0048730 ! epidermis morphogenesis [Term] id: GO:0031070 name: intronic snoRNA processing namespace: biological_process def: "The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA." [GOC:vw] is_a: GO:0043144 ! snoRNA processing [Term] id: GO:0031071 name: cysteine desulfurase activity namespace: molecular_function def: "Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine." [EC:2.8.1.7] synonym: "cysteine desulfurylase activity" EXACT [EC:2.8.1.7] synonym: "IscS" RELATED [EC:2.8.1.7] synonym: "L-cysteine:enzyme cysteine sulfurtransferase activity" EXACT [EC:2.8.1.7] synonym: "NIFS" RELATED [EC:2.8.1.7] synonym: "SufS" RELATED [EC:2.8.1.7] xref: EC:2.8.1.7 xref: reactome:R-HSA-1362408 "FXN:NFS1:ISD11:ISCU assembles 2Fe-2S iron-sulfur cluster" xref: reactome:R-HSA-947514 "NFS1 transfers sulfur from cysteine onto MOCS3" is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0031072 name: heat shock protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heat shock protein, any protein synthesized or activated in response to heat shock." [GOC:mah, GOC:vw] is_a: GO:0005515 ! protein binding [Term] id: GO:0031073 name: cholesterol 26-hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol." [GOC:mah, PMID:950499] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0031074 name: nucleocytoplasmic transport complex namespace: cellular_component def: "Any complex that acts to move proteins or RNAs into or out of the nucleus through nuclear pores." [GOC:mah] subset: gocheck_do_not_annotate subset: goslim_pir synonym: "nucleocytoplasmic shuttling complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031076 name: embryonic camera-type eye development namespace: biological_process def: "The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "embryonic eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048568 ! embryonic organ development [Term] id: GO:0031077 name: post-embryonic camera-type eye development namespace: biological_process def: "The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure." [GOC:mah, GOC:mtg_sensu] synonym: "post-embryonic camera-style eye development" EXACT [] is_a: GO:0043010 ! camera-type eye development is_a: GO:0048569 ! post-embryonic animal organ development relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0031078 name: histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0031079 name: obsolete picornain 3C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of GlnGly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly." [EC:3.4.22.28] comment: This term was made obsolete because it represents a gene product. synonym: "3C protease activity" EXACT [EC:3.4.22.28] synonym: "3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "coxsackievirus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "cysteine proteinase 3C" RELATED [EC:3.4.22.28] synonym: "foot-and-mouth protease 3C activity" NARROW [EC:3.4.22.28] synonym: "foot-and-mouth-disease virus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "hepatitis A virus 3C proteinase activity" EXACT [EC:3.4.22.28] synonym: "picornain 3C activity" EXACT [] synonym: "picornavirus endopeptidase 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "poliovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "protease 3C" RELATED [EC:3.4.22.28] synonym: "rhinovirus protease 3C activity" NARROW [EC:3.4.22.28] synonym: "rhinovirus proteinase 3C" RELATED [EC:3.4.22.28] synonym: "tomato ringspot nepovirus 3C-related protease" RELATED [EC:3.4.22.28] xref: EC:3.4.22.28 is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0031080 name: nuclear pore outer ring namespace: cellular_component def: "A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates)." [GOC:dgf, PMID:18046406, PMID:19524430, PMID:20947011, PMID:22419078] synonym: "Nup107-120 complex" EXACT [] synonym: "Nup107-160 complex" EXACT [] synonym: "Nup84 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005643 ! nuclear pore [Term] id: GO:0031081 name: nuclear pore distribution namespace: biological_process def: "Any process that establishes the spatial arrangement of nuclear pores within the nuclear envelope." [GOC:mah] synonym: "positioning of nuclear pores" RELATED [] is_a: GO:0006997 ! nucleus organization is_a: GO:0051664 ! nuclear pore localization [Term] id: GO:0031082 name: BLOC complex namespace: cellular_component def: "Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex." [PMID:15102850, PMID:15261680] subset: goslim_pir synonym: "BLOC-1 related complex" EXACT [PMID:25898167] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0031083 name: BLOC-1 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins." [PMID:15102850] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031084 name: BLOC-2 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru." [PMID:12548288, PMID:14718540, PMID:15031569] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031085 name: BLOC-3 complex namespace: cellular_component def: "A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins." [PMID:12756248] is_a: GO:0031082 ! BLOC complex [Term] id: GO:0031086 name: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay namespace: biological_process def: "A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent mRNA decay" EXACT [] synonym: "deadenylylation-independent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-independent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent" EXACT [] synonym: "mRNA catabolism, deadenylation-independent decay" EXACT [] synonym: "mRNA catabolism, deadenylylation-independent" EXACT [] synonym: "mRNA degradation, deadenylation-independent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-independent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0031087 name: deadenylation-independent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening." [GOC:krc, PMID:15225542, PMID:15225544] synonym: "deadenylation-independent decapping of nuclear mRNA" RELATED [] synonym: "deadenylylation-independent decapping" EXACT [] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0031086 ! nuclear-transcribed mRNA catabolic process, deadenylation-independent decay [Term] id: GO:0031088 name: platelet dense granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense granule." [GOC:mah] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031089 name: platelet dense granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet dense granule." [GOC:mah] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0042827 ! platelet dense granule [Term] id: GO:0031090 name: organelle membrane namespace: cellular_component def: "A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle." [GOC:dos, GOC:mah] synonym: "intracellular membrane" RELATED [NIF_Subcellular:sao830981606] xref: NIF_Subcellular:sao830981606 is_a: GO:0016020 ! membrane is_a: GO:0044422 ! organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031091 name: platelet alpha granule namespace: cellular_component def: "A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG)." [PMID:8467233] synonym: "platelet alpha-granule" EXACT [] xref: Wikipedia:Platelet_alpha-granule is_a: GO:0030141 ! secretory granule [Term] id: GO:0031092 name: platelet alpha granule membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule membrane" EXACT [] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031093 name: platelet alpha granule lumen namespace: cellular_component def: "The volume enclosed by the membrane of the platelet alpha granule." [GOC:mah, PMID:8467233] synonym: "platelet alpha-granule lumen" EXACT [] is_a: GO:0034774 ! secretory granule lumen relationship: part_of GO:0031091 ! platelet alpha granule [Term] id: GO:0031094 name: platelet dense tubular network namespace: cellular_component def: "A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin." [PMID:1322202] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0031095 name: platelet dense tubular network membrane namespace: cellular_component def: "The lipid bilayer surrounding the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0044424 ! intracellular part is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031096 name: platelet dense tubular network lumen namespace: cellular_component def: "The volume enclosed by the membranes of the platelet dense tubular network." [GOC:mah, PMID:1322202] is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031094 ! platelet dense tubular network [Term] id: GO:0031097 name: medial cortex namespace: cellular_component def: "A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation." [GOC:vw, PMID:15572668, PMID:19474789] synonym: "medial ring" EXACT [GOC:vw] is_a: GO:0032155 ! cell division site part is_a: GO:0099738 ! cell cortex region [Term] id: GO:0031098 name: stress-activated protein kinase signaling cascade namespace: biological_process def: "A series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays one or more of the signals." [GOC:mah] synonym: "JNK signaling pathway" NARROW [] synonym: "JNK signalling pathway" NARROW [] synonym: "SAPK signaling pathway" EXACT [] synonym: "SAPK signalling pathway" EXACT [] synonym: "stress-activated protein kinase signaling pathway" EXACT [] synonym: "stress-activated protein kinase signalling pathway" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031099 name: regeneration namespace: biological_process def: "The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass)." [GOC:mah, GOC:pr] xref: Wikipedia:Regeneration_(biology) is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0031100 name: animal organ regeneration namespace: biological_process def: "The regrowth of a lost or destroyed animal organ." [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0048513 ! animal organ development [Term] id: GO:0031101 name: fin regeneration namespace: biological_process def: "The regrowth of fin tissue following its loss or destruction." [GOC:dgh] is_a: GO:0042246 ! tissue regeneration [Term] id: GO:0031102 name: neuron projection regeneration namespace: biological_process def: "The regrowth of neuronal processes such as axons or dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] synonym: "neurite regeneration" NARROW [GOC:mah] is_a: GO:0031099 ! regeneration is_a: GO:0031175 ! neuron projection development is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0031103 name: axon regeneration namespace: biological_process def: "The regrowth of axons following their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0031102 ! neuron projection regeneration is_a: GO:0048678 ! response to axon injury is_a: GO:0061564 ! axon development [Term] id: GO:0031104 name: dendrite regeneration namespace: biological_process def: "The regrowth of dendrites in response to their loss or damage." [GOC:dgh, GOC:dph, GOC:tb] is_a: GO:0016358 ! dendrite development is_a: GO:0031102 ! neuron projection regeneration [Term] id: GO:0031105 name: septin complex namespace: cellular_component def: "A protein complex containing septins. Typically, these complexes contain multiple septins and are oligomeric." [GOC:mah, PMID:15385632] subset: goslim_pir is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0031106 name: septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of the septin ring." [GOC:mah] synonym: "septin ring organisation" EXACT [GOC:curators] is_a: GO:0032185 ! septin cytoskeleton organization [Term] id: GO:0031107 name: septin ring disassembly namespace: biological_process def: "The controlled breakdown of a septin ring." [GOC:mah] is_a: GO:0031106 ! septin ring organization is_a: GO:1903008 ! organelle disassembly [Term] id: GO:0031108 name: holo-[acyl-carrier-protein] biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of holo-[acyl-carrier protein]." [GOC:mlg] synonym: "holo-[acyl-carrier protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] anabolism" EXACT [] synonym: "holo-[acyl-carrier-protein] biosynthesis" EXACT [] synonym: "holo-[acyl-carrier-protein] formation" EXACT [] synonym: "holo-[acyl-carrier-protein] synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0019538 ! protein metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0031109 name: microtubule polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031110 name: regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule." [GOC:mah] is_a: GO:0070507 ! regulation of microtubule cytoskeleton organization relationship: regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031111 name: negative regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "down-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "downregulation of microtubule polymerization or depolymerization" EXACT [] synonym: "inhibition of microtubule polymerization or depolymerization" NARROW [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051494 ! negative regulation of cytoskeleton organization relationship: negatively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031112 name: positive regulation of microtubule polymerization or depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization." [GOC:mah] synonym: "activation of microtubule polymerization or depolymerization" NARROW [] synonym: "stimulation of microtubule polymerization or depolymerization" NARROW [] synonym: "up regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "up-regulation of microtubule polymerization or depolymerization" EXACT [] synonym: "upregulation of microtubule polymerization or depolymerization" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0051495 ! positive regulation of cytoskeleton organization relationship: positively_regulates GO:0031109 ! microtubule polymerization or depolymerization [Term] id: GO:0031113 name: regulation of microtubule polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule polymerization." [GOC:mah] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:0032271 ! regulation of protein polymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization relationship: regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031114 name: regulation of microtubule depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "regulation of microtubule disassembly" EXACT [] is_a: GO:0031110 ! regulation of microtubule polymerization or depolymerization is_a: GO:1901879 ! regulation of protein depolymerization is_a: GO:1902903 ! regulation of supramolecular fiber organization relationship: regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031115 name: negative regulation of microtubule polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "down regulation of microtubule polymerization" EXACT [] synonym: "down-regulation of microtubule polymerization" EXACT [] synonym: "downregulation of microtubule polymerization" EXACT [] synonym: "inhibition of microtubule polymerization" NARROW [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032272 ! negative regulation of protein polymerization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization relationship: negatively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031116 name: positive regulation of microtubule polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule polymerization." [GOC:mah] synonym: "activation of microtubule polymerization" NARROW [] synonym: "stimulation of microtubule polymerization" NARROW [] synonym: "up regulation of microtubule polymerization" EXACT [] synonym: "up-regulation of microtubule polymerization" EXACT [] synonym: "upregulation of microtubule polymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031113 ! regulation of microtubule polymerization is_a: GO:0032273 ! positive regulation of protein polymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization relationship: positively_regulates GO:0046785 ! microtubule polymerization [Term] id: GO:0031117 name: positive regulation of microtubule depolymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of microtubule depolymerization." [GOC:mah] synonym: "activation of microtubule depolymerization" NARROW [] synonym: "microtubule destabilization" EXACT [] synonym: "positive regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "positive regulation of microtubule disassembly" EXACT [] synonym: "stimulation of microtubule depolymerization" NARROW [] synonym: "up regulation of microtubule depolymerization" EXACT [] synonym: "up-regulation of microtubule depolymerization" EXACT [] synonym: "upregulation of microtubule depolymerization" EXACT [] is_a: GO:0031112 ! positive regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:1901881 ! positive regulation of protein depolymerization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization relationship: positively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0031118 name: rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001522 ! pseudouridine synthesis [Term] id: GO:0031119 name: tRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in a tRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0006400 ! tRNA modification [Term] id: GO:0031120 name: snRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an snRNA molecule." [GOC:mah] is_a: GO:0001522 ! pseudouridine synthesis is_a: GO:0040031 ! snRNA modification [Term] id: GO:0031121 name: equatorial microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell." [GOC:mah, GOC:vw] synonym: "equatorial microtubule organisation" EXACT [GOC:curators] synonym: "equatorial microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0031122 name: cytoplasmic microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell." [GOC:mah] synonym: "cytoplasmic microtubule organisation" EXACT [GOC:curators] synonym: "cytoplasmic microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:0097435 ! supramolecular fiber organization [Term] id: GO:0031123 name: RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule." [GOC:mah] synonym: "RNA 3' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031124 name: mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' end processing" EXACT [] is_a: GO:0006397 ! mRNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0031125 name: rRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an rRNA molecule." [GOC:mah] synonym: "rRNA 3' end processing" EXACT [] is_a: GO:0006364 ! rRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031126 name: snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a snoRNA molecule." [GOC:mah] synonym: "snoRNA 3' end processing" EXACT [] is_a: GO:0043144 ! snoRNA processing is_a: GO:0043628 ! ncRNA 3'-end processing [Term] id: GO:0031127 name: alpha-(1,2)-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage." [GOC:mah] synonym: "alpha-(1->2)-fucosyltransferase activity" EXACT [] synonym: "alpha-1,2-fucosyltransferase activity" EXACT [] is_a: GO:0008417 ! fucosyltransferase activity [Term] id: GO:0031128 name: developmental induction namespace: biological_process def: "A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder)." [GOC:cjm, GOC:dph, GOC:mah, PMID:24503535] is_a: GO:0032502 ! developmental process [Term] id: GO:0031129 name: inductive cell-cell signaling namespace: biological_process def: "Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate." [GOC:mah] synonym: "inductive cell-cell signalling" EXACT [] is_a: GO:0031128 ! developmental induction [Term] id: GO:0031130 name: creation of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter." [GOC:mah] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031131 name: reception of an inductive signal namespace: biological_process def: "The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change." [GOC:mah] is_a: GO:0031668 ! cellular response to extracellular stimulus relationship: part_of GO:0031129 ! inductive cell-cell signaling [Term] id: GO:0031132 name: serine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + NADP(+) = L-alpha-formylglycine + 2 H(+) + NADPH." [EC:1.1.1.276, RHEA:21596] synonym: "L-serine:NADP+ 3-oxidoreductase activity" EXACT [EC:1.1.1.276] xref: EC:1.1.1.276 xref: KEGG:R06126 xref: MetaCyc:RXN0-2201 xref: RHEA:21596 xref: Wikipedia:Serine_3-dehydrogenase is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0031133 name: regulation of axon diameter namespace: biological_process def: "Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0032536 ! regulation of cell projection size is_a: GO:0050770 ! regulation of axonogenesis [Term] id: GO:0031134 name: sister chromatid biorientation namespace: biological_process def: "The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles." [PMID:15309047] synonym: "chromosome biorientation" EXACT [] synonym: "sister kinetochore biorientation" EXACT [] is_a: GO:0008608 ! attachment of spindle microtubules to kinetochore relationship: part_of GO:0000819 ! sister chromatid segregation [Term] id: GO:0031135 name: negative regulation of conjugation namespace: biological_process def: "Any process that decreases the rate of conjugation." [GOC:mah] synonym: "down regulation of conjugation" EXACT [] synonym: "down-regulation of conjugation" EXACT [] synonym: "downregulation of conjugation" EXACT [] synonym: "inhibition of conjugation" NARROW [] is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0000746 ! conjugation [Term] id: GO:0031136 name: positive regulation of conjugation namespace: biological_process def: "Any process that increases the rate or frequency of conjugation." [GOC:mah] synonym: "activation of conjugation" NARROW [] synonym: "stimulation of conjugation" NARROW [] synonym: "up regulation of conjugation" EXACT [] synonym: "up-regulation of conjugation" EXACT [] synonym: "upregulation of conjugation" EXACT [] is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0046999 ! regulation of conjugation is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0000746 ! conjugation [Term] id: GO:0031137 name: regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that modulates the rate or frequency of conjugation with cellular fusion." [GOC:mah] is_a: GO:0046999 ! regulation of conjugation is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031138 name: negative regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that decreases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "down regulation of conjugation with cellular fusion" EXACT [] synonym: "down-regulation of conjugation with cellular fusion" EXACT [] synonym: "downregulation of conjugation with cellular fusion" EXACT [] synonym: "inhibition of conjugation with cellular fusion" NARROW [] is_a: GO:0031135 ! negative regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031139 name: positive regulation of conjugation with cellular fusion namespace: biological_process def: "Any process that increases the rate or frequency of conjugation with cellular fusion." [GOC:mah] synonym: "activation of conjugation with cellular fusion" NARROW [] synonym: "stimulation of conjugation with cellular fusion" NARROW [] synonym: "up regulation of conjugation with cellular fusion" EXACT [] synonym: "up-regulation of conjugation with cellular fusion" EXACT [] synonym: "upregulation of conjugation with cellular fusion" EXACT [] is_a: GO:0031136 ! positive regulation of conjugation is_a: GO:0031137 ! regulation of conjugation with cellular fusion is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0031140 name: induction of conjugation upon nutrient starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients." [GOC:mah] is_a: GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0031141 name: induction of conjugation upon carbon starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon carbon starvation." [GOC:mah] is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031142 name: induction of conjugation upon nitrogen starvation namespace: biological_process def: "The process in which a cell initiates conjugation with cellular fusion upon nitrogen starvation." [GOC:mah] is_a: GO:0006995 ! cellular response to nitrogen starvation is_a: GO:0031140 ! induction of conjugation upon nutrient starvation [Term] id: GO:0031143 name: pseudopodium namespace: cellular_component def: "A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding." [ISBN:0198506732] subset: goslim_pir synonym: "pseudopod" EXACT [] xref: Wikipedia:Pseudopod is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0031144 name: proteasome localization namespace: biological_process def: "Any process in which the proteasome is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of proteasome localization" EXACT [] synonym: "proteasome localisation" EXACT [GOC:mah] is_a: GO:0034629 ! cellular protein-containing complex localization [Term] id: GO:0031145 name: anaphase-promoting complex-dependent catabolic process namespace: biological_process alt_id: GO:0008054 def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome." [GOC:mah, PMID:15380083, PMID:15840442] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "APC-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "cyclin breakdown" NARROW [] synonym: "cyclin catabolic process" NARROW [] synonym: "cyclin catabolism" NARROW [] synonym: "cyclin degradation" NARROW [] synonym: "degradation of cyclin" NARROW [] synonym: "negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation" NARROW [] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0031146 name: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome." [PMID:15380083] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein breakdown" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein catabolism" EXACT [] synonym: "SCF-dependent proteasomal ubiquitin-dependent protein degradation" EXACT [] is_a: GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0031147 name: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolism" EXACT [] synonym: "DIF-1 metabolic process" EXACT [] synonym: "DIF-1 metabolism" EXACT [] is_a: GO:0018904 ! ether metabolic process is_a: GO:0018958 ! phenol-containing compound metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042537 ! benzene-containing compound metabolic process [Term] id: GO:0031148 name: DIF-1 biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells." [GOC:mah, PMID:10706822] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one anabolism" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthesis" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one biosynthetic process" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one formation" EXACT [] synonym: "1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one synthesis" EXACT [] synonym: "DIF-1 biosynthesis" EXACT [] is_a: GO:0031147 ! 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046189 ! phenol-containing compound biosynthetic process is_a: GO:1901503 ! ether biosynthetic process [Term] id: GO:0031149 name: sorocarp stalk cell differentiation namespace: biological_process def: "The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "stalk cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031150 ! sorocarp stalk development [Term] id: GO:0031150 name: sorocarp stalk development namespace: biological_process def: "The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:mtg_sensu, ISBN:0521583640] synonym: "sorophore development" EXACT [] synonym: "stalk development" BROAD [] synonym: "stalk formation" BROAD [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0031154 ! culmination involved in sorocarp development [Term] id: GO:0031151 name: histone methyltransferase activity (H3-K79 specific) namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein." [GOC:mah, PMID:15371351] synonym: "histone lysine N-methyltransferase activity (H3-K79 specific)" EXACT [] synonym: "histone methylase activity (H3-K79 specific)" EXACT [GOC:mah] is_a: GO:0018024 ! histone-lysine N-methyltransferase activity [Term] id: GO:0031152 name: aggregation involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "aggregate development involved in sorocarp development" EXACT [] synonym: "aggregation during fruiting body development" EXACT [] is_a: GO:0009267 ! cellular response to starvation is_a: GO:0044764 ! multi-organism cellular process is_a: GO:0098630 ! aggregation of unicellular organisms is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031153 name: slug development involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "migratory slug development during sorocarp development" NARROW [] synonym: "pseudoplasmodium biosynthesis" EXACT [] synonym: "pseudoplasmodium formation" EXACT [] synonym: "slug development during fruiting body development" EXACT [] synonym: "slug development during sorocarp development" RELATED [GOC:dph, GOC:tb] synonym: "standing slug development during sorocarp development" NARROW [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031154 name: culmination involved in sorocarp development namespace: biological_process def: "The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development." [GOC:mah, GOC:mtg_sensu, ISBN:0521583640] synonym: "culminant development" EXACT [] synonym: "culmination during fruiting body development" EXACT [] synonym: "culmination during sorocarp development" RELATED [] is_a: GO:0099120 ! socially cooperative development relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031155 name: regulation of reproductive fruiting body development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reproductive fruiting body development." [GOC:mah] synonym: "regulation of fruiting body formation" EXACT [] is_a: GO:0075260 ! regulation of spore-bearing organ development relationship: regulates GO:0030582 ! reproductive fruiting body development [Term] id: GO:0031156 name: regulation of sorocarp development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:2530, GOC:mah, GOC:mtg_sensu] synonym: "regulation of fruiting body development" BROAD [] synonym: "regulation of fruiting body formation" BROAD [] is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0050793 ! regulation of developmental process relationship: regulates GO:0030587 ! sorocarp development [Term] id: GO:0031157 name: regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that modulates the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, GOC:pg] synonym: "regulation of aggregation during fruiting body biosynthesis" RELATED [] synonym: "regulation of aggregation during fruiting body formation" RELATED [] is_a: GO:0060176 ! regulation of aggregation involved in sorocarp development is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031158 name: negative regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that decreases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:mtg_sensu, GOC:pg] synonym: "down regulation of aggregate size" EXACT [] synonym: "down-regulation of aggregate size" EXACT [] synonym: "downregulation of aggregate size" EXACT [] synonym: "inhibition of aggregate size" NARROW [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031159 name: positive regulation of aggregate size involved in sorocarp development namespace: biological_process def: "Any process that increases the size of the aggregate formed during sorocarp formation." [dictyBase_REF:5048, GOC:mah, GOC:pg] synonym: "activation of aggregate size" NARROW [] synonym: "stimulation of aggregate size" NARROW [] synonym: "up regulation of aggregate size" EXACT [] synonym: "up-regulation of aggregate size" EXACT [] synonym: "upregulation of aggregate size" EXACT [] is_a: GO:0031157 ! regulation of aggregate size involved in sorocarp development [Term] id: GO:0031160 name: spore wall namespace: cellular_component def: "The specialized envelope lying outside the cell membrane of a spore." [GOC:mah, GOC:pg] synonym: "spore coat" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0031161 name: phosphatidylinositol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:mah] synonym: "phosphatidylinositol breakdown" EXACT [] synonym: "phosphatidylinositol catabolism" EXACT [] synonym: "phosphatidylinositol degradation" EXACT [] synonym: "PtdIns catabolic process" EXACT [] synonym: "PtdIns catabolism" EXACT [] is_a: GO:0046475 ! glycerophospholipid catabolic process is_a: GO:0046488 ! phosphatidylinositol metabolic process [Term] id: GO:0031162 name: sulfur incorporation into metallo-sulfur cluster namespace: biological_process def: "The incorporation of exogenous sulfur into a metallo-sulfur cluster." [GOC:mah] synonym: "sulphur incorporation into metallo-sulphur cluster" EXACT [] is_a: GO:0006464 ! cellular protein modification process is_a: GO:0006790 ! sulfur compound metabolic process relationship: part_of GO:0031163 ! metallo-sulfur cluster assembly [Term] id: GO:0031163 name: metallo-sulfur cluster assembly namespace: biological_process def: "The incorporation of a metal and exogenous sulfur into a metallo-sulfur cluster." [GOC:jl, GOC:mah, GOC:pde, GOC:vw] synonym: "metal-sulfur cluster assembly" EXACT [GOC:pr] synonym: "metallo-sulfur cluster biosynthesis" RELATED [] synonym: "metallo-sulphur cluster assembly" EXACT [] is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0031164 name: contractile vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the contractile vacuole." [GOC:pg] synonym: "contractile vacuole membrane" EXACT [GOC:mah, GOC:pf] is_a: GO:0005774 ! vacuolar membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0000331 ! contractile vacuole [Term] id: GO:0031165 name: integral component of contractile vacuolar membrane namespace: cellular_component def: "The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:pg] synonym: "integral to contractile vacuolar membrane" EXACT [] is_a: GO:0031166 ! integral component of vacuolar membrane is_a: GO:0031311 ! intrinsic component of contractile vacuolar membrane [Term] id: GO:0031166 name: integral component of vacuolar membrane namespace: cellular_component def: "The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:dos, GOC:mah] synonym: "integral to vacuolar membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031310 ! intrinsic component of vacuolar membrane [Term] id: GO:0031167 name: rRNA methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule." [GOC:mah] is_a: GO:0000154 ! rRNA modification is_a: GO:0001510 ! RNA methylation [Term] id: GO:0031168 name: ferrichrome metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] synonym: "ferrichrome metabolism" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0031169 name: ferrichrome biosynthetic process namespace: biological_process alt_id: GO:0031199 alt_id: GO:0031200 def: "The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine." [GOC:mah, ISBN:0198506732] synonym: "ferrichrome anabolism" EXACT [] synonym: "ferrichrome biosynthesis" EXACT [] synonym: "ferrichrome biosynthetic process, peptide formation" NARROW [] synonym: "ferrichrome biosynthetic process, peptide modification" NARROW [] synonym: "ferrichrome formation" EXACT [] synonym: "ferrichrome synthesis" EXACT [] is_a: GO:0019539 ! siderophore biosynthetic process from hydroxamic acid is_a: GO:0031168 ! ferrichrome metabolic process [Term] id: GO:0031170 name: ferricrocin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin metabolism" EXACT [] is_a: GO:0031168 ! ferrichrome metabolic process [Term] id: GO:0031171 name: ferricrocin biosynthetic process namespace: biological_process alt_id: GO:0031185 alt_id: GO:0031186 def: "The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3." [GOC:mah, PMID:12828635] synonym: "ferricrocin anabolism" EXACT [] synonym: "ferricrocin biosynthesis" EXACT [] synonym: "ferricrocin biosynthetic process, peptide formation" NARROW [] synonym: "ferricrocin biosynthetic process, peptide modification" NARROW [] synonym: "ferricrocin formation" EXACT [] synonym: "ferricrocin synthesis" EXACT [] is_a: GO:0031169 ! ferrichrome biosynthetic process is_a: GO:0031170 ! ferricrocin metabolic process [Term] id: GO:0031172 name: ornithine N5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + O2 + H+ = N5-hydroxy-L-ornithine + H2O." [MetaCyc:RXN-11128, PMID:12828635] synonym: "L-ornithine 5-monooxygenase activity" EXACT [MetaCyc:RXN-11128] xref: MetaCyc:RXN-11128 is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0031173 name: otolith mineralization completed early in development namespace: biological_process def: "The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear." [GOC:dsf, PMID:15581873] synonym: "otoconia mineralization" EXACT [] synonym: "otoconium mineralization" EXACT [] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031174 name: lifelong otolith mineralization namespace: biological_process def: "The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added." [GOC:dsf, PMID:15581873] is_a: GO:0045299 ! otolith mineralization [Term] id: GO:0031175 name: neuron projection development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites)." [GOC:mah] synonym: "neurite biosynthesis" NARROW [] synonym: "neurite development" NARROW [GOC:dph] synonym: "neurite formation" NARROW [] synonym: "neurite growth" NARROW [] synonym: "neurite outgrowth" NARROW [] is_a: GO:0120036 ! plasma membrane bounded cell projection organization relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0031176 name: endo-1,4-beta-xylanase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-xylosidic linkages in xylans." [EC:3.2.1.8] synonym: "1,4-beta-D-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "1,4-beta-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylan xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "beta-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1,4)-beta-xylanase(1,4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-(1->4)-beta-xylanase(1->4)-beta-xylan 4-xylanohydrolase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-beta-D-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "endo-beta-1,4-xylanase activity" EXACT [EC:3.2.1.8] synonym: "xylanase" BROAD [EC:3.2.1.8] xref: EC:3.2.1.8 xref: MetaCyc:3.2.1.8-RXN is_a: GO:0097599 ! xylanase activity [Term] id: GO:0031177 name: phosphopantetheine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate)." [CHEBI:16858, GOC:mah, GOC:vw] is_a: GO:0019842 ! vitamin binding is_a: GO:0033218 ! amide binding is_a: GO:0043168 ! anion binding is_a: GO:0048037 ! cofactor binding is_a: GO:0072341 ! modified amino acid binding [Term] id: GO:0031179 name: peptide modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide." [GOC:mah] is_a: GO:0006518 ! peptide metabolic process [Term] id: GO:0031201 name: SNARE complex namespace: cellular_component def: "A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25." [GOC:bhm, GOC:pr, PMID:10872468, PMID:19450911] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0031203 name: posttranslational protein targeting to membrane, docking namespace: biological_process def: "The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex." [PMID:12518217, PMID:8707814] synonym: "posttranslational protein membrane targeting, docking" EXACT [] synonym: "protein docking during posttranslational protein targeting to membrane" EXACT [] synonym: "Sec-translated protein complex assembly" EXACT [] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane [Term] id: GO:0031204 name: posttranslational protein targeting to membrane, translocation namespace: biological_process def: "The process in which a protein translocates through the ER membrane posttranslationally." [PMID:12518317, PMID:8707814] synonym: "posttranslational protein membrane targeting, translocation" EXACT [] synonym: "protein translocation during posttranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006620 ! posttranslational protein targeting to endoplasmic reticulum membrane [Term] id: GO:0031205 name: endoplasmic reticulum Sec complex namespace: cellular_component def: "An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex." [GOC:mtg_sensu, PMID:12158317, PMID:14617809] subset: goslim_pir is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0031207 name: Sec62/Sec63 complex namespace: cellular_component def: "A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p." [PMID:12518317, PMID:14617809] synonym: "ER protein translocation subcomplex" EXACT [] synonym: "Sec62/63 complex" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031205 ! endoplasmic reticulum Sec complex [Term] id: GO:0031208 name: POZ domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors." [PMID:7958847] synonym: "broad-complex, tramtrack, and bric-a-brac domain binding" EXACT [] synonym: "BTB domain" EXACT [PMID:22621901] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0031209 name: SCAR complex namespace: cellular_component def: "A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction." [GOC:hla, GOC:pg, PMID:12181570, PMID:24036345, PMID:24630101] synonym: "WAVE complex" EXACT [] synonym: "WAVE regulatory complex" EXACT [] synonym: "WRC" BROAD [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031210 name: phosphatidylcholine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylcholine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:mah, ISBN:0198506732] is_a: GO:0005543 ! phospholipid binding is_a: GO:0050997 ! quaternary ammonium group binding is_a: GO:0070405 ! ammonium ion binding [Term] id: GO:0031211 name: endoplasmic reticulum palmitoyltransferase complex namespace: cellular_component def: "A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue." [GOC:jh] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex is_a: GO:1905961 ! protein-cysteine S-palmitoyltransferase complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031213 name: RSF complex namespace: cellular_component def: "An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters)." [GOC:krc, PMID:12972596, PMID:15284901, PMID:16568949, PMID:21810179] synonym: "remodeling and spacing factor complex" EXACT [] is_a: GO:0031010 ! ISWI-type complex [Term] id: GO:0031214 name: biomineral tissue development namespace: biological_process def: "Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation." [PMID:15132736] synonym: "biomineral formation" RELATED [GOC:dph, GOC:tb] synonym: "biomineralization" EXACT [] synonym: "mineralization" EXACT [] xref: Wikipedia:Biomineralisation is_a: GO:0009888 ! tissue development relationship: part_of GO:0048513 ! animal organ development [Term] id: GO:0031215 name: shell calcification namespace: biological_process def: "The precipitation of calcium carbonate onto the organic matrix of a shell, such as a mollusc shell." [GOC:mah, PMID:15132736] is_a: GO:0031214 ! biomineral tissue development [Term] id: GO:0031216 name: neopullulanase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pullulan to panose (6-alpha-D-glucosylmaltose)." [EC:3.2.1.135, GOC:mlg] synonym: "pullulan 4-D-glucanohydrolase (panose-forming)" EXACT [EC:3.2.1.135] synonym: "pullulanase II activity" EXACT [] xref: EC:3.2.1.135 xref: MetaCyc:3.2.1.135-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031217 name: glucan 1,4-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units." [EC:3.2.1.74, GOC:mlg] synonym: "1,4-beta-D-glucan glucohydrolase activity" BROAD [EC:3.2.1.74] synonym: "beta-1,4-beta-glucanase activity" BROAD [EC:3.2.1.74] synonym: "beta-1,4-glucanase activity" BROAD [] synonym: "exo-1,4-beta-D-glucosidase activity" EXACT [EC:3.2.1.74] synonym: "exo-1,4-beta-glucanase activity" EXACT [] synonym: "exo-1,4-beta-glucosidase activity" EXACT [] synonym: "exo-beta-1,4-glucanase activity" EXACT [] synonym: "exo-beta-1,4-glucosidase activity" EXACT [] synonym: "exocellulase activity" EXACT [] xref: EC:3.2.1.74 xref: MetaCyc:3.2.1.74-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0031218 name: arabinogalactan endo-1,4-beta-galactosidase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of (1->4)-beta-D-galactosidic linkages in arabinogalactans." [EC:3.2.1.89, GOC:mlg] synonym: "arabinogalactan 4-beta-D-galactanohydrolase activity" EXACT [EC:3.2.1.89] synonym: "arabinogalactanase activity" EXACT [] synonym: "endo-1,4-beta-galactanase activity" EXACT [] synonym: "galactanase activity" EXACT [] xref: EC:3.2.1.89 xref: MetaCyc:3.2.1.89-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0031219 name: levanase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units." [EC:3.2.1.65, GOC:mlg] synonym: "2,6-beta-D-fructan fructanohydrolase activity" EXACT [EC:3.2.1.65] synonym: "levan hydrolase activity" EXACT [] xref: EC:3.2.1.65 xref: MetaCyc:3.2.1.65-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0031220 name: maltodextrin phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: maltodextrin = glucose-1-phosphate." [GOC:mlg, PMID:10348846] xref: MetaCyc:RXN-9025 xref: MetaCyc:RXN0-5182 is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0031221 name: arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] synonym: "arabinan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0031222 name: arabinan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues." [GOC:mlg, ISBN:0198506732] synonym: "arabinan breakdown" EXACT [] synonym: "arabinan catabolism" EXACT [] synonym: "arabinan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0031223 name: auditory behavior namespace: biological_process def: "The behavior of an organism in response to a sound." [GOC:pr, GOC:rc] synonym: "auditory behaviour" EXACT [] synonym: "behavioral response to sound" EXACT [] synonym: "behavioural response to sound" EXACT [] is_a: GO:0007638 ! mechanosensory behavior relationship: part_of GO:0010996 ! response to auditory stimulus [Term] id: GO:0031224 name: intrinsic component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane." [GOC:mah] comment: Note that proteins intrinsic to membranes cannot be removed without disrupting the membrane, e.g. by detergent. subset: goslim_metagenomics synonym: "intrinsic to membrane" NARROW [] is_a: GO:0044425 ! membrane part [Term] id: GO:0031225 name: anchored component of membrane namespace: cellular_component def: "The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] synonym: "anchored to membrane" EXACT [] is_a: GO:0031224 ! intrinsic component of membrane [Term] id: GO:0031226 name: intrinsic component of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plasma membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031227 name: intrinsic component of endoplasmic reticulum membrane namespace: cellular_component def: "The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to endoplasmic reticulum membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031228 name: intrinsic component of Golgi membrane namespace: cellular_component def: "The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to Golgi membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0000139 ! Golgi membrane [Term] id: GO:0031229 name: intrinsic component of nuclear inner membrane namespace: cellular_component def: "The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to nuclear inner membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005637 ! nuclear inner membrane [Term] id: GO:0031230 name: intrinsic component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to cell outer membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031231 name: intrinsic component of peroxisomal membrane namespace: cellular_component def: "The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to peroxisomal membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044439 ! peroxisomal part relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0031232 name: extrinsic component of external side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "extrinsic to external side of plasma membrane" NARROW [] is_a: GO:0019897 ! extrinsic component of plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031233 name: intrinsic component of external side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah] synonym: "intrinsic to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "intrinsic to external side of plasma membrane" NARROW [] is_a: GO:0031226 ! intrinsic component of plasma membrane relationship: part_of GO:0009897 ! external side of plasma membrane [Term] id: GO:0031234 name: extrinsic component of cytoplasmic side of plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region." [GOC:mah] comment: Consider also annotating to 'cell cortex ; GO:0005938'. synonym: "extrinsic to cytoplasmic side of plasma membrane" NARROW [] synonym: "extrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "extrinsic to internal side of plasma membrane" EXACT [] is_a: GO:0019897 ! extrinsic component of plasma membrane is_a: GO:0044424 ! intracellular part relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0031235 name: intrinsic component of the cytoplasmic side of the plasma membrane namespace: cellular_component def: "The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only." [GOC:dos, GOC:mah] synonym: "intrinsic to cytoplasmic side of plasma membrane" NARROW [] synonym: "intrinsic to internal leaflet of plasma membrane" EXACT [GOC:ab] synonym: "intrinsic to internal side of plasma membrane" EXACT [] is_a: GO:0031226 ! intrinsic component of plasma membrane relationship: part_of GO:0009898 ! cytoplasmic side of plasma membrane [Term] id: GO:0031236 name: extrinsic component of periplasmic side of plasma membrane namespace: cellular_component alt_id: GO:0031238 def: "The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to external leaflet of plasma membrane, in periplasmic space" NARROW [GOC:ab] synonym: "extrinsic to external side of plasma membrane, in periplasmic space" NARROW [] is_a: GO:0031232 ! extrinsic component of external side of plasma membrane relationship: part_of GO:0098567 ! periplasmic side of plasma membrane [Term] id: GO:0031237 name: intrinsic component of periplasmic side of plasma membrane namespace: cellular_component alt_id: GO:0031239 def: "The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external leaflet of plasma membrane, in periplasmic space" EXACT [GOC:ab] synonym: "intrinsic to periplasmic side of plasma membrane" EXACT [] is_a: GO:0031233 ! intrinsic component of external side of plasma membrane relationship: part_of GO:0098567 ! periplasmic side of plasma membrane [Term] id: GO:0031240 name: external side of cell outer membrane namespace: cellular_component def: "The side of the outer membrane that is opposite to the side that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "external side of outer membrane" RELATED [] is_a: GO:0044462 ! external encapsulating structure part is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031241 name: periplasmic side of cell outer membrane namespace: cellular_component def: "The side (leaflet) of the outer membrane that faces the periplasm of the cell." [GOC:mlg, GOC:mtg_sensu] comment: In GO, 'internal side' still refers to part of the membrane and does not refer to components beyond (inside of) the membrane. synonym: "internal leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "internal side of cell outer membrane" EXACT [] synonym: "internal side of outer membrane" EXACT [] is_a: GO:0044462 ! external encapsulating structure part is_a: GO:0098552 ! side of membrane relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031242 name: extrinsic component of external side of cell outer membrane namespace: cellular_component def: "The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "extrinsic to external side of cell outer membrane" NARROW [] synonym: "extrinsic to external side of outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic component of cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031243 name: intrinsic component of external side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "intrinsic to external side of cell outer membrane" NARROW [] synonym: "intrinsic to external side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic component of cell outer membrane relationship: part_of GO:0031240 ! external side of cell outer membrane [Term] id: GO:0031244 name: extrinsic component of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to cell outer membrane" NARROW [] is_a: GO:0019898 ! extrinsic component of membrane is_a: GO:0044462 ! external encapsulating structure part relationship: part_of GO:0009279 ! cell outer membrane [Term] id: GO:0031245 name: extrinsic component of periplasmic side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "extrinsic to internal leaflet of cell outer membrane" NARROW [GOC:ab] synonym: "extrinsic to internal side of cell outer membrane" EXACT [] synonym: "extrinsic to internal side of outer membrane" EXACT [] synonym: "extrinsic to periplasmic side of cell outer membrane" EXACT [] is_a: GO:0031244 ! extrinsic component of cell outer membrane relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane [Term] id: GO:0031246 name: intrinsic component of periplasmic side of cell outer membrane namespace: cellular_component def: "The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor." [GOC:dos, GOC:mah, GOC:mtg_sensu] synonym: "intrinsic to external side of cell outer membrane" NARROW [] synonym: "intrinsic to internal leaflet of cell outer membrane" EXACT [GOC:ab] synonym: "intrinsic to internal side of cell outer membrane" EXACT [] synonym: "intrinsic to internal side of outer membrane" EXACT [] is_a: GO:0031230 ! intrinsic component of cell outer membrane relationship: part_of GO:0031241 ! periplasmic side of cell outer membrane [Term] id: GO:0031247 name: actin rod assembly namespace: biological_process def: "The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules." [GOC:pg, PMID:14706699] synonym: "actin rod formation" RELATED [GOC:mah] is_a: GO:0051017 ! actin filament bundle assembly [Term] id: GO:0031248 name: protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to a protein acceptor molecule." [GOC:bf] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1902493 ! acetyltransferase complex [Term] id: GO:0031249 name: denatured protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with denatured proteins." [GOC:mlg] comment: Note that this term should not be confused with 'unfolded protein binding ; GO:0051082', which usually refers to proteins that have not yet folded into their active states. Denatured proteins once were in their correct functional conformations, but have become incorrectly folded, and often form aggregates. is_a: GO:0005515 ! protein binding [Term] id: GO:0031250 name: anaerobic ribonucleoside-triphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit." [GOC:mlg] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031251 name: PAN complex namespace: cellular_component def: "A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces." [PMID:9774670] synonym: "poly(A) nuclease complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031252 name: cell leading edge namespace: cellular_component def: "The area of a motile cell closest to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "front of cell" EXACT [] synonym: "leading edge of cell" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0031253 name: cell projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasma membrane bounded cell surface projection." [GOC:mah] {comment="GOC:krc"} synonym: "membrane extension" RELATED [] synonym: "membrane projection" RELATED [] is_a: GO:0098590 ! plasma membrane region is_a: GO:0120038 ! plasma membrane bounded cell projection part [Term] id: GO:0031254 name: cell trailing edge namespace: cellular_component def: "The area of a motile cell opposite to the direction of movement." [GOC:pg] subset: goslim_pir synonym: "back of cell" EXACT [] synonym: "trailing edge" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0031255 name: lateral part of motile cell namespace: cellular_component def: "The area of a motile cell perpendicular to the direction of movement." [GOC:pg, GOC:pr] is_a: GO:0097574 ! lateral part of cell [Term] id: GO:0031256 name: leading edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the leading edge of a motile cell." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0031257 name: cell trailing edge membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the trailing edge of a motile cell." [GOC:mah] synonym: "trailing edge membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0031254 ! cell trailing edge [Term] id: GO:0031258 name: lamellipodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a lamellipodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0030027 ! lamellipodium [Term] id: GO:0031259 name: uropod membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a uropod." [GOC:mah] synonym: "uropodium membrane" EXACT [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031257 ! cell trailing edge membrane relationship: part_of GO:0001931 ! uropod [Term] id: GO:0031260 name: pseudopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a pseudopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0031143 ! pseudopodium [Term] id: GO:0031261 name: DNA replication preinitiation complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present." [GOC:bf, GOC:hjd, GOC:jl, GOC:pr, GOC:rb, GOC:vw, PMID:12694535, PMID:15194812, PMID:17230184] synonym: "pre-IC" EXACT [] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0031262 name: Ndc80 complex namespace: cellular_component def: "A protein complex conserved among eukaryotes that forms part of the kinetochore and plays an essential role in forming stable kinetochore-microtubule attachments. The complex contains proteins known in several species, including budding and fission yeasts, as Ndc80p, Nuf2p, Spc24p, and Spc25p. In vertebrates it is part of the outer plate of the kinetochore." [PMID:15509863, PMID:15661517] synonym: "Nuf2-Ndc80 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000776 ! kinetochore [Term] id: GO:0031263 name: amine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + amine(out) = ADP + phosphate + amine(in)." [GOC:mlg] synonym: "amine ABC transporter" NARROW [] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0031264 name: death-inducing signaling complex namespace: cellular_component def: "A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10." [GOC:mtg_apoptosis, PMID:12628743, PMID:12655293, PMID:8521815] comment: Gene products that may be annotated to this term include: 1) ligand-bound receptors such as FAS/CD95 (though care should be taken because FAS can also act as a non-apoptotic signal transducer); 2) signaling molecules such as FADD (FAS-associated protein with a death domain), cIAPs (cellular inhibitor of apoptosis proteins), c-FLIPs and caspases 8 and 10. subset: goslim_pir synonym: "death receptor-induced signaling complex" EXACT [] synonym: "death receptor-induced signalling complex" EXACT [] synonym: "death-inducing signalling complex" EXACT [] synonym: "DISC" EXACT [] synonym: "DISC protein complex" EXACT [] xref: Wikipedia:Death-inducing_signaling_complex is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0031265 name: CD95 death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "CD95 death-inducing signalling complex" EXACT [] synonym: "CD95 DISC" EXACT [] synonym: "Fas death-inducing signaling complex" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031266 name: TRAIL death-inducing signaling complex namespace: cellular_component def: "A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor." [PMID:12628743, PMID:12655293] synonym: "TRAIL death-inducing signalling complex" EXACT [] synonym: "TRAIL DISC" EXACT [] is_a: GO:0031264 ! death-inducing signaling complex [Term] id: GO:0031267 name: small GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small monomeric GTPase." [GOC:mah] is_a: GO:0051020 ! GTPase binding [Term] id: GO:0031268 name: pseudopodium organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement." [GOC:pg] synonym: "pseudopodium organisation" EXACT [GOC:curators] synonym: "pseudopodium organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0031269 name: pseudopodium assembly namespace: biological_process def: "The assembly of a pseudopodium by rearrangement of the actin cytoskeleton and overlying membrane." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "pseudopodium extension" EXACT [] synonym: "pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031268 ! pseudopodium organization is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0031270 name: pseudopodium retraction namespace: biological_process def: "The myosin-based contraction and retraction of the pseudopodium." [GOC:pg] is_a: GO:0031268 ! pseudopodium organization [Term] id: GO:0031271 name: lateral pseudopodium assembly namespace: biological_process def: "The extension of a pseudopodium from the lateral area of a cell." [GOC:dph, GOC:mah, GOC:pg, GOC:tb] synonym: "lateral pseudopodium formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0031269 ! pseudopodium assembly [Term] id: GO:0031272 name: regulation of pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "regulation of pseudopodium formation" RELATED [] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly relationship: regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031273 name: negative regulation of pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "down regulation of pseudopodium formation" RELATED [] synonym: "down-regulation of pseudopodium formation" RELATED [] synonym: "downregulation of pseudopodium formation" RELATED [] synonym: "inhibition of pseudopodium formation" NARROW [] synonym: "negative regulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120033 ! negative regulation of plasma membrane bounded cell projection assembly relationship: negatively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031274 name: positive regulation of pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia." [GOC:pg] synonym: "activation of pseudopodium formation" NARROW [] synonym: "positive regulation of pseudopodium formation" RELATED [GOC:dph] synonym: "stimulation of pseudopodium formation" NARROW [] synonym: "up regulation of pseudopodium formation" RELATED [] synonym: "up-regulation of pseudopodium formation" RELATED [] synonym: "upregulation of pseudopodium formation" RELATED [] is_a: GO:0031272 ! regulation of pseudopodium assembly is_a: GO:0120034 ! positive regulation of plasma membrane bounded cell projection assembly relationship: positively_regulates GO:0031269 ! pseudopodium assembly [Term] id: GO:0031275 name: regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "regulation of lateral pseudopodium formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031272 ! regulation of pseudopodium assembly relationship: regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031276 name: negative regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "down regulation of lateral pseudopodium formation" RELATED [] synonym: "down-regulation of lateral pseudopodium formation" RELATED [] synonym: "downregulation of lateral pseudopodium formation" RELATED [] synonym: "inhibition of lateral pseudopodium formation" NARROW [] synonym: "negative regulation of lateral pseudopodium formation" RELATED [GOC:dph] is_a: GO:0031273 ! negative regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly relationship: negatively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031277 name: positive regulation of lateral pseudopodium assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia from the lateral side of the cell." [GOC:dph, GOC:pg, GOC:tb] synonym: "activation of lateral pseudopodium formation" NARROW [] synonym: "positive regulation of lateral pseudopodium formation" RELATED [] synonym: "stimulation of lateral pseudopodium formation" NARROW [] synonym: "up regulation of lateral pseudopodium formation" RELATED [] synonym: "up-regulation of lateral pseudopodium formation" RELATED [] synonym: "upregulation of lateral pseudopodium formation" RELATED [] is_a: GO:0031274 ! positive regulation of pseudopodium assembly is_a: GO:0031275 ! regulation of lateral pseudopodium assembly relationship: positively_regulates GO:0031271 ! lateral pseudopodium assembly [Term] id: GO:0031278 name: alpha-1,2-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage." [PMID:7522655] xref: EC:2.4.1 is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0031279 name: regulation of cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclase activity." [GOC:mah] is_a: GO:0050790 ! regulation of catalytic activity [Term] id: GO:0031280 name: negative regulation of cyclase activity namespace: biological_process def: "Any process that stops or reduces the activity of a cyclase." [GOC:mah] synonym: "down regulation of cyclase activity" EXACT [] synonym: "down-regulation of cyclase activity" EXACT [] synonym: "downregulation of cyclase activity" EXACT [] synonym: "inhibition of cyclase activity" NARROW [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043086 ! negative regulation of catalytic activity [Term] id: GO:0031281 name: positive regulation of cyclase activity namespace: biological_process def: "Any process that activates or increases the activity of a cyclase." [GOC:mah] synonym: "activation of cyclase activity" NARROW [] synonym: "stimulation of cyclase activity" NARROW [] synonym: "up regulation of cyclase activity" EXACT [] synonym: "up-regulation of cyclase activity" EXACT [] synonym: "upregulation of cyclase activity" EXACT [] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0043085 ! positive regulation of catalytic activity [Term] id: GO:0031282 name: regulation of guanylate cyclase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] is_a: GO:0031279 ! regulation of cyclase activity is_a: GO:0051339 ! regulation of lyase activity is_a: GO:1900371 ! regulation of purine nucleotide biosynthetic process [Term] id: GO:0031283 name: negative regulation of guanylate cyclase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "down regulation of guanylate cyclase activity" EXACT [] synonym: "down-regulation of guanylate cyclase activity" EXACT [] synonym: "downregulation of guanylate cyclase activity" EXACT [] synonym: "inhibition of guanylate cyclase activity" NARROW [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity is_a: GO:1900372 ! negative regulation of purine nucleotide biosynthetic process [Term] id: GO:0031284 name: positive regulation of guanylate cyclase activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity." [GOC:mah] synonym: "activation of guanylate cyclase activity" NARROW [] synonym: "stimulation of guanylate cyclase activity" NARROW [] synonym: "up regulation of guanylate cyclase activity" EXACT [] synonym: "up-regulation of guanylate cyclase activity" EXACT [] synonym: "upregulation of guanylate cyclase activity" EXACT [] is_a: GO:0031281 ! positive regulation of cyclase activity is_a: GO:0031282 ! regulation of guanylate cyclase activity is_a: GO:0051349 ! positive regulation of lyase activity is_a: GO:1900373 ! positive regulation of purine nucleotide biosynthetic process [Term] id: GO:0031285 name: regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu] synonym: "regulation of stalk cell differentiation" EXACT [] is_a: GO:0031156 ! regulation of sorocarp development is_a: GO:0045595 ! regulation of cell differentiation relationship: regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031286 name: negative regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu] synonym: "down regulation of stalk cell differentiation" EXACT [] synonym: "down-regulation of stalk cell differentiation" EXACT [] synonym: "downregulation of stalk cell differentiation" EXACT [] synonym: "inhibition of stalk cell differentiation" NARROW [] synonym: "negative regulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0075262 ! negative regulation of spore-bearing organ development relationship: negatively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031287 name: positive regulation of sorocarp stalk cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu] synonym: "activation of stalk cell differentiation" NARROW [] synonym: "positive regulation of stalk cell differentiation" EXACT [] synonym: "stimulation of stalk cell differentiation" NARROW [] synonym: "up regulation of stalk cell differentiation" EXACT [] synonym: "up-regulation of stalk cell differentiation" EXACT [] synonym: "upregulation of stalk cell differentiation" EXACT [] is_a: GO:0031285 ! regulation of sorocarp stalk cell differentiation is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0043902 ! positive regulation of multi-organism process is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0075261 ! positive regulation of spore-bearing organ development relationship: positively_regulates GO:0031149 ! sorocarp stalk cell differentiation [Term] id: GO:0031288 name: sorocarp morphogenesis namespace: biological_process def: "The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum." [dictyBase_REF:5048, GOC:kp, GOC:mtg_sensu] synonym: "fruiting body morphogenesis" BROAD [DDANAT:0000012] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0030587 ! sorocarp development [Term] id: GO:0031289 name: actin phosphorylation namespace: biological_process def: "The transfer of one or more phosphate groups to an actin molecule." [GOC:mah] is_a: GO:0006468 ! protein phosphorylation is_a: GO:0030047 ! actin modification [Term] id: GO:0031290 name: retinal ganglion cell axon guidance namespace: biological_process def: "The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues." [GOC:ejs] synonym: "retinal ganglion cell axon pathfinding" EXACT [] is_a: GO:0007411 ! axon guidance [Term] id: GO:0031291 name: Ran protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0031292 name: gene conversion at mating-type locus, DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break at the mating-type locus to form a 3' single-strand DNA overhang." [GOC:mah] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0031293 name: membrane protein intracellular domain proteolysis namespace: biological_process def: "The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain." [PMID:12808018] synonym: "membrane protein solubilization" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0031294 name: lymphocyte costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation." [ISBN:0781735149] synonym: "lymphocyte co-stimulation" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0051251 ! positive regulation of lymphocyte activation [Term] id: GO:0031295 name: T cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation." [ISBN:0781735149] synonym: "T cell co-stimulation" EXACT [] synonym: "T lymphocyte costimulation" EXACT [] synonym: "T-cell co-stimulation" EXACT [] synonym: "T-cell costimulation" EXACT [] synonym: "T-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050870 ! positive regulation of T cell activation [Term] id: GO:0031296 name: B cell costimulation namespace: biological_process def: "The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation." [ISBN:0781735149] synonym: "B cell co-stimulation" EXACT [] synonym: "B lymphocyte co-stimulation" EXACT [] synonym: "B lymphocyte costimulation" EXACT [] synonym: "B-cell co-stimulation" EXACT [] synonym: "B-cell costimulation" EXACT [] synonym: "B-lymphocyte co-stimulation" EXACT [] synonym: "B-lymphocyte costimulation" EXACT [] is_a: GO:0031294 ! lymphocyte costimulation is_a: GO:0050871 ! positive regulation of B cell activation [Term] id: GO:0031297 name: replication fork processing namespace: biological_process alt_id: GO:0034065 def: "The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes." [GOC:vw, PMID:11459955, PMID:15367656, PMID:17660542] synonym: "collapsed replication fork processing" EXACT [] synonym: "recovery from replication fork arrest" EXACT [] synonym: "recovery from replication fork arrest at rDNA locus" NARROW [] synonym: "recovery from replication fork stalling" EXACT [] synonym: "recovery from replication fork stalling at rDNA locus" NARROW [] synonym: "replication fork processing at rDNA locus" NARROW [] synonym: "replication fork processing at ribosomal DNA locus" NARROW [] synonym: "replication fork restart" RELATED [PMID:20842177] synonym: "replication restart" RELATED [GOC:bhm, PMID:15780929] is_a: GO:0045005 ! DNA-dependent DNA replication maintenance of fidelity [Term] id: GO:0031298 name: replication fork protection complex namespace: cellular_component def: "A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling." [PMID:15367656] synonym: "replisome progression complex" EXACT [GOC:vw] synonym: "Swi1-Swi3 complex" NARROW [] synonym: "TIMELESS-TIPIN complex" NARROW [GOC:mah, GOC:vw] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043596 ! nuclear replication fork [Term] id: GO:0031299 name: taurine-pyruvate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + taurine = L-alanine + sulfoacetaldehyde." [EC:2.6.1.77, RHEA:10420] synonym: "taurine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.77] synonym: "Tpa" RELATED [EC:2.6.1.77] xref: EC:2.6.1.77 xref: KEGG:R05652 xref: MetaCyc:TAURINE-AMINOTRANSFERASE-RXN xref: RHEA:10420 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0031300 name: intrinsic component of organelle membrane namespace: cellular_component def: "The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to organelle membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane is_a: GO:0044422 ! organelle part relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031301 name: integral component of organelle membrane namespace: cellular_component def: "The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to organelle membrane" EXACT [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031300 ! intrinsic component of organelle membrane [Term] id: GO:0031302 name: intrinsic component of endosome membrane namespace: cellular_component def: "The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to endosome membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031303 name: integral component of endosome membrane namespace: cellular_component def: "The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to endosome membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031302 ! intrinsic component of endosome membrane [Term] id: GO:0031304 name: intrinsic component of mitochondrial inner membrane namespace: cellular_component def: "The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to mitochondrial inner membrane" NARROW [] is_a: GO:0098573 ! intrinsic component of mitochondrial membrane relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031305 name: integral component of mitochondrial inner membrane namespace: cellular_component def: "The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial inner membrane" EXACT [] is_a: GO:0031304 ! intrinsic component of mitochondrial inner membrane is_a: GO:0032592 ! integral component of mitochondrial membrane [Term] id: GO:0031306 name: intrinsic component of mitochondrial outer membrane namespace: cellular_component def: "The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to mitochondrial outer membrane" NARROW [] is_a: GO:0098573 ! intrinsic component of mitochondrial membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031307 name: integral component of mitochondrial outer membrane namespace: cellular_component def: "The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial outer membrane" NARROW [] is_a: GO:0031306 ! intrinsic component of mitochondrial outer membrane is_a: GO:0032592 ! integral component of mitochondrial membrane [Term] id: GO:0031308 name: intrinsic component of nuclear outer membrane namespace: cellular_component def: "The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to nuclear outer membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031309 name: integral component of nuclear outer membrane namespace: cellular_component def: "The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to nuclear outer membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031308 ! intrinsic component of nuclear outer membrane [Term] id: GO:0031310 name: intrinsic component of vacuolar membrane namespace: cellular_component def: "The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to vacuolar membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0031311 name: intrinsic component of contractile vacuolar membrane namespace: cellular_component def: "The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to contractile vacuolar membrane" NARROW [] is_a: GO:0031310 ! intrinsic component of vacuolar membrane is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031312 name: extrinsic component of organelle membrane namespace: cellular_component def: "The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to organelle membrane" NARROW [] is_a: GO:0019898 ! extrinsic component of membrane is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0031090 ! organelle membrane [Term] id: GO:0031313 name: extrinsic component of endosome membrane namespace: cellular_component def: "The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to endosome membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0031314 name: extrinsic component of mitochondrial inner membrane namespace: cellular_component def: "The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to mitochondrial inner membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0031315 name: extrinsic component of mitochondrial outer membrane namespace: cellular_component def: "The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to mitochondrial outer membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0031316 name: extrinsic component of nuclear outer membrane namespace: cellular_component def: "The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to nuclear outer membrane" NARROW [] is_a: GO:0031312 ! extrinsic component of organelle membrane is_a: GO:0044453 ! nuclear membrane part relationship: part_of GO:0005640 ! nuclear outer membrane [Term] id: GO:0031317 name: tripartite ATP-independent periplasmic transporter complex namespace: cellular_component def: "A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients." [GOC:mlg] synonym: "TRAP transporter complex" EXACT [] synonym: "TRAP-T transporter complex" EXACT [] is_a: GO:0044464 ! cell part is_a: GO:1990351 ! transporter complex [Term] id: GO:0031318 name: detection of folic acid namespace: biological_process def: "The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "detection of folate" EXACT [] synonym: "folate detection" EXACT [] synonym: "folate sensing" EXACT [] synonym: "folic acid detection" EXACT [] synonym: "folic acid sensing" EXACT [] is_a: GO:0009594 ! detection of nutrient is_a: GO:0051593 ! response to folic acid [Term] id: GO:0031319 name: detection of cAMP namespace: biological_process def: "The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP." [GOC:pg] synonym: "3',5'-cAMP detection" EXACT [] synonym: "3',5'-cAMP sensing" EXACT [] synonym: "cAMP detection" EXACT [] synonym: "cAMP sensing" EXACT [] synonym: "cyclic AMP detection" EXACT [] synonym: "detection of 3',5' cAMP" EXACT [] synonym: "detection of 3',5'-cAMP" EXACT [] synonym: "detection of adenosine 3',5'-cyclophosphate" EXACT [] synonym: "detection of cyclic AMP" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051591 ! response to cAMP [Term] id: GO:0031320 name: hexitol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: hexitol + acceptor = hexose + reduced acceptor." [GOC:mah] is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0031321 name: ascospore-type prospore assembly namespace: biological_process def: "During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore formation" EXACT [] synonym: "forespore formation" RELATED [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030437 ! ascospore formation [Term] id: GO:0031322 name: ascospore-type prospore-specific spindle pole body remodeling namespace: biological_process def: "A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP)." [GOC:mah, PMID:14702385] synonym: "ascospore-type prospore-specific spindle pole body modification" RELATED [GOC:vw] synonym: "ascospore-type prospore-specific spindle pole body remodelling" EXACT [GOC:mah] synonym: "forespore specific spindle pole body remodeling" EXACT [] synonym: "forespore-specific spindle pole body remodeling" EXACT [] synonym: "prospore-specific spindle pole body remodeling" EXACT [] synonym: "sporulation-specific spindle pole body remodeling" EXACT [] is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0031321 ! ascospore-type prospore assembly [Term] id: GO:0031323 name: regulation of cellular metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "regulation of cellular metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031324 name: negative regulation of cellular metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "down regulation of cellular metabolic process" EXACT [] synonym: "down-regulation of cellular metabolic process" EXACT [] synonym: "downregulation of cellular metabolic process" EXACT [] synonym: "inhibition of cellular metabolic process" NARROW [] synonym: "negative regulation of cellular metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048523 ! negative regulation of cellular process relationship: negatively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031325 name: positive regulation of cellular metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances." [GOC:mah] synonym: "activation of cellular metabolic process" NARROW [] synonym: "positive regulation of cellular metabolism" EXACT [] synonym: "stimulation of cellular metabolic process" NARROW [] synonym: "up regulation of cellular metabolic process" EXACT [] synonym: "up-regulation of cellular metabolic process" EXACT [] synonym: "upregulation of cellular metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0044237 ! cellular metabolic process [Term] id: GO:0031326 name: regulation of cellular biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular anabolism" EXACT [] synonym: "regulation of cellular biosynthesis" EXACT [] synonym: "regulation of cellular formation" EXACT [] synonym: "regulation of cellular synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031327 name: negative regulation of cellular biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular biosynthetic process" EXACT [] synonym: "down-regulation of cellular biosynthetic process" EXACT [] synonym: "downregulation of cellular biosynthetic process" EXACT [] synonym: "inhibition of cellular biosynthetic process" NARROW [] synonym: "negative regulation of cellular anabolism" EXACT [] synonym: "negative regulation of cellular biosynthesis" EXACT [] synonym: "negative regulation of cellular formation" EXACT [] synonym: "negative regulation of cellular synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: negatively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031328 name: positive regulation of cellular biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular biosynthetic process" NARROW [] synonym: "positive regulation of cellular anabolism" EXACT [] synonym: "positive regulation of cellular biosynthesis" EXACT [] synonym: "positive regulation of cellular formation" EXACT [] synonym: "positive regulation of cellular synthesis" EXACT [] synonym: "stimulation of cellular biosynthetic process" NARROW [] synonym: "up regulation of cellular biosynthetic process" EXACT [] synonym: "up-regulation of cellular biosynthetic process" EXACT [] synonym: "upregulation of cellular biosynthetic process" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process relationship: positively_regulates GO:0044249 ! cellular biosynthetic process [Term] id: GO:0031329 name: regulation of cellular catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "regulation of cellular breakdown" EXACT [] synonym: "regulation of cellular catabolism" EXACT [] synonym: "regulation of cellular degradation" EXACT [] is_a: GO:0009894 ! regulation of catabolic process is_a: GO:0031323 ! regulation of cellular metabolic process relationship: regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031330 name: negative regulation of cellular catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "down regulation of cellular catabolic process" EXACT [] synonym: "down-regulation of cellular catabolic process" EXACT [] synonym: "downregulation of cellular catabolic process" EXACT [] synonym: "inhibition of cellular catabolic process" NARROW [] synonym: "negative regulation of cellular breakdown" EXACT [] synonym: "negative regulation of cellular catabolism" EXACT [] synonym: "negative regulation of cellular degradation" EXACT [] is_a: GO:0009895 ! negative regulation of catabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: negatively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031331 name: positive regulation of cellular catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells." [GOC:mah] synonym: "activation of cellular catabolic process" NARROW [] synonym: "positive regulation of cellular breakdown" EXACT [] synonym: "positive regulation of cellular catabolism" EXACT [] synonym: "positive regulation of cellular degradation" EXACT [] synonym: "stimulation of cellular catabolic process" NARROW [] synonym: "up regulation of cellular catabolic process" EXACT [] synonym: "up-regulation of cellular catabolic process" EXACT [] synonym: "upregulation of cellular catabolic process" EXACT [] is_a: GO:0009896 ! positive regulation of catabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031329 ! regulation of cellular catabolic process relationship: positively_regulates GO:0044248 ! cellular catabolic process [Term] id: GO:0031332 name: RNAi effector complex namespace: cellular_component def: "Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins." [GOC:mah, PMID:14704433] subset: goslim_pir is_a: GO:1990904 ! ribonucleoprotein complex [Term] id: GO:0031333 name: negative regulation of protein complex assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "down regulation of protein complex assembly" EXACT [] synonym: "down-regulation of protein complex assembly" EXACT [] synonym: "downregulation of protein complex assembly" EXACT [] synonym: "inhibition of protein complex assembly" NARROW [] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031334 name: positive regulation of protein complex assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein complex assembly." [GOC:mah] synonym: "activation of protein complex assembly" NARROW [] synonym: "stimulation of protein complex assembly" NARROW [] synonym: "up regulation of protein complex assembly" EXACT [] synonym: "up-regulation of protein complex assembly" EXACT [] synonym: "upregulation of protein complex assembly" EXACT [] is_a: GO:0043254 ! regulation of protein complex assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0065003 ! protein-containing complex assembly [Term] id: GO:0031335 name: regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process is_a: GO:0042762 ! regulation of sulfur metabolic process relationship: regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031336 name: negative regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "down regulation of sulfur amino acid metabolic process" EXACT [] synonym: "down-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "downregulation of sulfur amino acid metabolic process" EXACT [] synonym: "inhibition of sulfur amino acid metabolic process" NARROW [] synonym: "negative regulation of sulfur amino acid metabolism" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045763 ! negative regulation of cellular amino acid metabolic process is_a: GO:0051175 ! negative regulation of sulfur metabolic process relationship: negatively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031337 name: positive regulation of sulfur amino acid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids." [GOC:mah] synonym: "activation of sulfur amino acid metabolic process" NARROW [] synonym: "positive regulation of sulfur amino acid metabolism" EXACT [] synonym: "stimulation of sulfur amino acid metabolic process" NARROW [] synonym: "up regulation of sulfur amino acid metabolic process" EXACT [] synonym: "up-regulation of sulfur amino acid metabolic process" EXACT [] synonym: "upregulation of sulfur amino acid metabolic process" EXACT [] is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process is_a: GO:0045764 ! positive regulation of cellular amino acid metabolic process is_a: GO:0051176 ! positive regulation of sulfur metabolic process relationship: positively_regulates GO:0000096 ! sulfur amino acid metabolic process [Term] id: GO:0031338 name: regulation of vesicle fusion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vesicle fusion." [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0060627 ! regulation of vesicle-mediated transport relationship: regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031339 name: negative regulation of vesicle fusion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "down regulation of vesicle fusion" EXACT [] synonym: "down-regulation of vesicle fusion" EXACT [] synonym: "downregulation of vesicle fusion" EXACT [] synonym: "inhibition of vesicle fusion" NARROW [] is_a: GO:0010639 ! negative regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031340 name: positive regulation of vesicle fusion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of vesicle fusion." [GOC:mah] synonym: "activation of vesicle fusion" NARROW [] synonym: "stimulation of vesicle fusion" NARROW [] synonym: "up regulation of vesicle fusion" EXACT [] synonym: "up-regulation of vesicle fusion" EXACT [] synonym: "upregulation of vesicle fusion" EXACT [] is_a: GO:0010638 ! positive regulation of organelle organization is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0006906 ! vesicle fusion [Term] id: GO:0031341 name: regulation of cell killing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism." [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0001906 ! cell killing [Term] id: GO:0031342 name: negative regulation of cell killing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cell killing." [GOC:mah] synonym: "down regulation of cell killing" EXACT [] synonym: "down-regulation of cell killing" EXACT [] synonym: "downregulation of cell killing" EXACT [] synonym: "inhibition of cell killing" NARROW [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048519 ! negative regulation of biological process relationship: negatively_regulates GO:0001906 ! cell killing [Term] id: GO:0031343 name: positive regulation of cell killing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cell killing." [GOC:mah] synonym: "activation of cell killing" NARROW [] synonym: "stimulation of cell killing" NARROW [] synonym: "up regulation of cell killing" EXACT [] synonym: "up-regulation of cell killing" EXACT [] synonym: "upregulation of cell killing" EXACT [] is_a: GO:0031341 ! regulation of cell killing is_a: GO:0048518 ! positive regulation of biological process relationship: positively_regulates GO:0001906 ! cell killing [Term] id: GO:0031344 name: regulation of cell projection organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "regulation of cell projection organisation" EXACT [GOC:curators] synonym: "regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0030030 ! cell projection organization [Term] id: GO:0031345 name: negative regulation of cell projection organization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "down regulation of cell projection organization" EXACT [GOC:mah] synonym: "down-regulation of cell projection organization" EXACT [] synonym: "downregulation of cell projection organization" EXACT [] synonym: "inhibition of cell projection organization" NARROW [] synonym: "negative regulation of cell projection organisation" EXACT [GOC:curators] synonym: "negative regulation of cell projection organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051129 ! negative regulation of cellular component organization relationship: negatively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031346 name: positive regulation of cell projection organization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections." [GOC:mah] synonym: "activation of cell projection organization" NARROW [] synonym: "positive regulation of cell projection organisation" EXACT [GOC:curators] synonym: "positive regulation of cell projection organization and biogenesis" RELATED [GOC:mah] synonym: "stimulation of cell projection organization" NARROW [] synonym: "up regulation of cell projection organization" EXACT [] synonym: "up-regulation of cell projection organization" EXACT [] synonym: "upregulation of cell projection organization" EXACT [] is_a: GO:0031344 ! regulation of cell projection organization is_a: GO:0051130 ! positive regulation of cellular component organization relationship: positively_regulates GO:0030030 ! cell projection organization [Term] id: GO:0031347 name: regulation of defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a defense response." [GOC:mah] is_a: GO:0080134 ! regulation of response to stress relationship: regulates GO:0006952 ! defense response [Term] id: GO:0031348 name: negative regulation of defense response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a defense response." [GOC:mah] synonym: "down regulation of defense response" EXACT [] synonym: "down-regulation of defense response" EXACT [] synonym: "downregulation of defense response" EXACT [] synonym: "inhibition of defense response" NARROW [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0006952 ! defense response [Term] id: GO:0031349 name: positive regulation of defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a defense response." [GOC:mah] synonym: "activation of defense response" NARROW [] synonym: "stimulation of defense response" NARROW [] synonym: "up regulation of defense response" EXACT [] synonym: "up-regulation of defense response" EXACT [] synonym: "upregulation of defense response" EXACT [] is_a: GO:0031347 ! regulation of defense response is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0006952 ! defense response [Term] id: GO:0031350 name: intrinsic component of plastid membrane namespace: cellular_component def: "The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid membrane" NARROW [] is_a: GO:0031300 ! intrinsic component of organelle membrane is_a: GO:0044435 ! plastid part relationship: part_of GO:0042170 ! plastid membrane [Term] id: GO:0031351 name: integral component of plastid membrane namespace: cellular_component def: "The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0031350 ! intrinsic component of plastid membrane [Term] id: GO:0031352 name: intrinsic component of plastid inner membrane namespace: cellular_component def: "The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid inner membrane" NARROW [] is_a: GO:0031350 ! intrinsic component of plastid membrane relationship: part_of GO:0009528 ! plastid inner membrane [Term] id: GO:0031353 name: integral component of plastid inner membrane namespace: cellular_component def: "The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid inner membrane" NARROW [] is_a: GO:0031351 ! integral component of plastid membrane is_a: GO:0031352 ! intrinsic component of plastid inner membrane [Term] id: GO:0031354 name: intrinsic component of plastid outer membrane namespace: cellular_component def: "The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to plastid outer membrane" NARROW [] is_a: GO:0031350 ! intrinsic component of plastid membrane relationship: part_of GO:0009527 ! plastid outer membrane [Term] id: GO:0031355 name: integral component of plastid outer membrane namespace: cellular_component def: "The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to plastid outer membrane" NARROW [] is_a: GO:0031351 ! integral component of plastid membrane is_a: GO:0031354 ! intrinsic component of plastid outer membrane [Term] id: GO:0031356 name: intrinsic component of chloroplast inner membrane namespace: cellular_component def: "The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to chloroplast inner membrane" NARROW [] is_a: GO:0031352 ! intrinsic component of plastid inner membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031357 name: integral component of chloroplast inner membrane namespace: cellular_component def: "The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to chloroplast inner membrane" NARROW [] is_a: GO:0031353 ! integral component of plastid inner membrane is_a: GO:0031356 ! intrinsic component of chloroplast inner membrane [Term] id: GO:0031358 name: intrinsic component of chloroplast outer membrane namespace: cellular_component def: "The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to chloroplast outer membrane" NARROW [] is_a: GO:0031354 ! intrinsic component of plastid outer membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0031359 name: integral component of chloroplast outer membrane namespace: cellular_component def: "The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to chloroplast outer membrane" NARROW [] is_a: GO:0031355 ! integral component of plastid outer membrane is_a: GO:0031358 ! intrinsic component of chloroplast outer membrane [Term] id: GO:0031360 name: intrinsic component of thylakoid membrane namespace: cellular_component def: "The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane." [GOC:dos, GOC:mah] synonym: "intrinsic to thylakoid membrane" NARROW [] is_a: GO:0031224 ! intrinsic component of membrane is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0042651 ! thylakoid membrane [Term] id: GO:0031361 name: integral component of thylakoid membrane namespace: cellular_component def: "The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to thylakoid membrane" NARROW [] is_a: GO:0016021 ! integral component of membrane is_a: GO:0031360 ! intrinsic component of thylakoid membrane [Term] id: GO:0031362 name: anchored component of external side of plasma membrane namespace: cellular_component def: "The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping." [GOC:dos, GOC:mah] synonym: "anchored to external leaflet of plasma membrane" EXACT [GOC:ab] synonym: "anchored to external side of plasma membrane" EXACT [] is_a: GO:0031233 ! intrinsic component of external side of plasma membrane is_a: GO:0046658 ! anchored component of plasma membrane [Term] id: GO:0031363 name: N-terminal protein amino acid deamination namespace: biological_process def: "The removal of an amino group from the N-terminal amino acid residue of a protein." [GOC:mah] is_a: GO:0031365 ! N-terminal protein amino acid modification [Term] id: GO:0031364 name: N-terminal protein amino acid deamination, from side chain namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein." [GOC:mah] is_a: GO:0031363 ! N-terminal protein amino acid deamination [Term] id: GO:0031365 name: N-terminal protein amino acid modification namespace: biological_process alt_id: GO:0018409 def: "The alteration of the N-terminal amino acid residue in a protein." [GOC:mah] synonym: "peptide or protein amino-terminal blocking" RELATED [] synonym: "peptide/protein amino-terminal blocking" RELATED [] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0031366 name: N-terminal peptidyl-asparagine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal asparagine residue of a protein." [GOC:bf, GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031367 name: N-terminal peptidyl-glutamine deamination namespace: biological_process def: "The removal of an amino group from the side chain of an N-terminal glutamine residue of a protein." [GOC:mah] is_a: GO:0031364 ! N-terminal protein amino acid deamination, from side chain [Term] id: GO:0031368 name: obsolete Pro-X metallocarboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a metallopeptidase mechanism to release a C-terminal amino acid." [EC:3.4.17.16, GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase P activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-X carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "membrane Pro-Xaa carboxypeptidase" NARROW [] synonym: "microsomal carboxypeptidase activity" NARROW [EC:3.4.17.16] synonym: "Pro-X metallocarboxypeptidase activity" EXACT [] xref: EC:3.4.17.16 is_obsolete: true consider: GO:0004181 consider: GO:0008233 [Term] id: GO:0031369 name: translation initiation factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0031370 name: eukaryotic initiation factor 4G binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation." [GOC:mah] synonym: "eIF4G binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0031371 name: ubiquitin conjugating enzyme complex namespace: cellular_component def: "Any complex that possesses ubiquitin conjugating enzyme activity." [GOC:mah] subset: goslim_pir synonym: "E2 complex" RELATED [] is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0031372 name: UBC13-MMS2 complex namespace: cellular_component def: "A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p." [GOC:mah, PMID:15772086] is_a: GO:0031371 ! ubiquitin conjugating enzyme complex [Term] id: GO:0031375 name: obsolete type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Type II refers to the type of fatty acid synthase. Type I is in a complex, type II is not. synonym: "type II FAS" EXACT [] synonym: "type II FAS complex" EXACT [] synonym: "type II fatty acid synthase" EXACT [] synonym: "type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031376 name: obsolete cytosolic type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the cytosol." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] synonym: "cytosolic type II FAS complex" EXACT [] synonym: "cytosolic type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031377 name: obsolete mitochondrial type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in the mitochondrion." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthases are not complexes synonym: "mitochondrial type II FAS complex" EXACT [] synonym: "mitochondrial type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031378 name: obsolete plastid type II fatty acid synthase complex namespace: cellular_component def: "OBSOLETE A fatty acid synthase complex in which each polypeptide chain catalyzes a single activity, located in a plastid." [GOC:mah, ISBN:0471331309, ISBN:0716720094, PMID:12957385] comment: Obsoleted because type II fatty acid synthase is not a complex. synonym: "plastid type II FAS complex" EXACT [] synonym: "plastid type II fatty acid synthase complex" EXACT [] is_obsolete: true [Term] id: GO:0031379 name: RNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses RNA-directed RNA polymerase activity." [GOC:mah] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0031380 name: nuclear RNA-directed RNA polymerase complex namespace: cellular_component def: "A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain." [GOC:vw, PMID:15607976] synonym: "Rdr1 complex" NARROW [] synonym: "RDRC" EXACT [] is_a: GO:0031379 ! RNA-directed RNA polymerase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031381 name: viral RNA-directed RNA polymerase complex namespace: cellular_component def: "A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus." [GOC:mah, PMID:15574411, PMID:15613301] is_a: GO:0031379 ! RNA-directed RNA polymerase complex [Term] id: GO:0031382 name: mating projection assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi." [GOC:mah, PMID:14734532] synonym: "mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0120031 ! plasma membrane bounded cell projection assembly relationship: part_of GO:0000753 ! cell morphogenesis involved in conjugation with cellular fusion [Term] id: GO:0031383 name: regulation of mating projection assembly namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi." [PMID:14734532] synonym: "regulation of mating projection biogenesis" RELATED [GOC:mah] is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly is_a: GO:1905708 ! regulation of cell morphogenesis involved in conjugation with cellular fusion relationship: regulates GO:0031382 ! mating projection assembly [Term] id: GO:0031384 name: regulation of initiation of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031385 name: regulation of termination of mating projection growth namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi." [PMID:14734532] is_a: GO:0031383 ! regulation of mating projection assembly [Term] id: GO:0031386 name: protein tag namespace: molecular_function def: "A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation." [GOC:dos, GOC:go_curators, PMID:19028679, PMID:20054389, PMID:6305978] comment: Use this term to annotate conjugated tags, not for conjugating enzymes. At the time of writing, all known gene products with this activity are ubiquitin-like, either based on overall sequence similarity or the presence of common motifs and structures. subset: goslim_pir synonym: "covalent modifier" RELATED [GOC:vw] synonym: "protein tagging activity" RELATED [] synonym: "ubiquitin" RELATED [] synonym: "ubiquitin-like protein modifier" EXACT [] is_a: GO:0003674 ! molecular_function [Term] id: GO:0031387 name: MPF complex namespace: cellular_component def: "A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC)." [PMID:12045216] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex [Term] id: GO:0031388 name: organic acid phosphorylation namespace: biological_process def: "The process of introducing one or more phosphate groups into an organic acid." [GOC:mah] is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0016310 ! phosphorylation [Term] id: GO:0031389 name: Rad17 RFC-like complex namespace: cellular_component def: "A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842] synonym: "Rad17-RFC" EXACT [] synonym: "Rad17-RLC" EXACT [] synonym: "Rad24p RFC-like complex" EXACT [] synonym: "RFC (Rad17)" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031390 name: Ctf18 RFC-like complex namespace: cellular_component def: "A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p." [PMID:14614842] synonym: "Ctf18-RFC" EXACT [] synonym: "Ctf18-RLC" EXACT [] synonym: "RFC (Ctf18)" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031391 name: Elg1 RFC-like complex namespace: cellular_component def: "A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p." [PMID:14614842, PMID:23499004, PMID:27664980] synonym: "Elg1-RFC" EXACT [] synonym: "Elg1-RLC" EXACT [] synonym: "RFC (Elg1)" EXACT [] is_a: GO:0044427 ! chromosomal part is_a: GO:1904949 ! ATPase complex [Term] id: GO:0031392 name: regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "regulation of prostaglandin anabolism" EXACT [] synonym: "regulation of prostaglandin biosynthesis" EXACT [] synonym: "regulation of prostaglandin formation" EXACT [] synonym: "regulation of prostaglandin synthesis" EXACT [] is_a: GO:2001279 ! regulation of unsaturated fatty acid biosynthetic process relationship: regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031393 name: negative regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "down regulation of prostaglandin biosynthetic process" EXACT [] synonym: "down-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "downregulation of prostaglandin biosynthetic process" EXACT [] synonym: "inhibition of prostaglandin biosynthetic process" NARROW [] synonym: "negative regulation of prostaglandin anabolism" EXACT [] synonym: "negative regulation of prostaglandin biosynthesis" EXACT [] synonym: "negative regulation of prostaglandin formation" EXACT [] synonym: "negative regulation of prostaglandin synthesis" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:0045717 ! negative regulation of fatty acid biosynthetic process relationship: negatively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031394 name: positive regulation of prostaglandin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin." [GOC:mah] synonym: "activation of prostaglandin biosynthetic process" NARROW [] synonym: "positive regulation of prostaglandin anabolism" EXACT [] synonym: "positive regulation of prostaglandin biosynthesis" EXACT [] synonym: "positive regulation of prostaglandin formation" EXACT [] synonym: "positive regulation of prostaglandin synthesis" EXACT [] synonym: "stimulation of prostaglandin biosynthetic process" NARROW [] synonym: "up regulation of prostaglandin biosynthetic process" EXACT [] synonym: "up-regulation of prostaglandin biosynthetic process" EXACT [] synonym: "upregulation of prostaglandin biosynthetic process" EXACT [] is_a: GO:0031392 ! regulation of prostaglandin biosynthetic process is_a: GO:2001280 ! positive regulation of unsaturated fatty acid biosynthetic process relationship: positively_regulates GO:0001516 ! prostaglandin biosynthetic process [Term] id: GO:0031395 name: bursicon neuropeptide hormone complex namespace: cellular_component def: "A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits." [GOC:rc] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0031396 name: regulation of protein ubiquitination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] is_a: GO:1903320 ! regulation of protein modification by small protein conjugation or removal relationship: regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031397 name: negative regulation of protein ubiquitination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "down regulation of protein ubiquitination" EXACT [] synonym: "down-regulation of protein ubiquitination" EXACT [] synonym: "downregulation of protein ubiquitination" EXACT [] synonym: "inhibition of protein ubiquitination" NARROW [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:1903321 ! negative regulation of protein modification by small protein conjugation or removal relationship: negatively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031398 name: positive regulation of protein ubiquitination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein." [GOC:mah] synonym: "activation of protein ubiquitination" NARROW [] synonym: "stimulation of protein ubiquitination" NARROW [] synonym: "up regulation of protein ubiquitination" EXACT [] synonym: "up-regulation of protein ubiquitination" EXACT [] synonym: "upregulation of protein ubiquitination" EXACT [] is_a: GO:0031396 ! regulation of protein ubiquitination is_a: GO:1903322 ! positive regulation of protein modification by small protein conjugation or removal relationship: positively_regulates GO:0016567 ! protein ubiquitination [Term] id: GO:0031399 name: regulation of protein modification process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] subset: goslim_yeast is_a: GO:0032268 ! regulation of cellular protein metabolic process relationship: regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031400 name: negative regulation of protein modification process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "down regulation of protein modification" EXACT [] synonym: "down-regulation of protein modification" EXACT [] synonym: "downregulation of protein modification" EXACT [] synonym: "inhibition of protein modification" NARROW [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032269 ! negative regulation of cellular protein metabolic process relationship: negatively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031401 name: positive regulation of protein modification process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein." [GOC:mah, GOC:tb] synonym: "activation of protein modification" NARROW [] synonym: "stimulation of protein modification" NARROW [] synonym: "up regulation of protein modification" EXACT [] synonym: "up-regulation of protein modification" EXACT [] synonym: "upregulation of protein modification" EXACT [] is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0032270 ! positive regulation of cellular protein metabolic process relationship: positively_regulates GO:0006464 ! cellular protein modification process [Term] id: GO:0031402 name: sodium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with sodium ions (Na+)." [GOC:mah] is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031403 name: lithium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lithium ions (Li+)." [GOC:mah] is_a: GO:0031420 ! alkali metal ion binding [Term] id: GO:0031404 name: chloride ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with chloride ions (Cl-)." [GOC:mah] synonym: "chloride binding" EXACT [] is_a: GO:0043168 ! anion binding [Term] id: GO:0031405 name: lipoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoic acid, 1,2-dithiolane-3-pentanoic acid." [GOC:mah, ISBN:0198506732] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding is_a: GO:0097159 ! organic cyclic compound binding is_a: GO:1901363 ! heterocyclic compound binding is_a: GO:1901681 ! sulfur compound binding [Term] id: GO:0031406 name: carboxylic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a carboxylic acid, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-)." [GOC:mah, ISBN:0198506732] subset: goslim_pir is_a: GO:0043168 ! anion binding is_a: GO:0043177 ! organic acid binding [Term] id: GO:0031407 name: oxylipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] synonym: "oxylipin metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0031408 name: oxylipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids." [GOC:mah, PMID:11960741] synonym: "oxylipin anabolism" EXACT [] synonym: "oxylipin biosynthesis" EXACT [] synonym: "oxylipin formation" EXACT [] synonym: "oxylipin synthesis" EXACT [] is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0031407 ! oxylipin metabolic process [Term] id: GO:0031409 name: pigment binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pigment, any general or particular coloring matter in living organisms, e.g. melanin." [GOC:mah] subset: goslim_pir is_a: GO:0005488 ! binding [Term] id: GO:0031410 name: cytoplasmic vesicle namespace: cellular_component alt_id: GO:0016023 def: "A vesicle found in the cytoplasm of a cell." [GOC:ai, GOC:mah, GOC:vesicles] subset: goslim_agr subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_mouse subset: goslim_yeast synonym: "cytoplasmic membrane bounded vesicle" RELATED [] synonym: "cytoplasmic membrane-enclosed vesicle" RELATED [] synonym: "cytoplasmic, membrane-bounded vesicle" RELATED [] xref: NIF_Subcellular:sao180601769 is_a: GO:0044444 ! cytoplasmic part is_a: GO:0097708 ! intracellular vesicle [Term] id: GO:0031411 name: gas vesicle namespace: cellular_component def: "An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations." [PMID:22147705, PMID:8177173] comment: Note that although this organelle is commonly referred to as a 'vesicle' or 'vacuole' in the literature, it is not surrounded by a membrane. synonym: "gas vacuole" RELATED [GOC:pr] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031412 name: gas vesicle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps." [GOC:mah] comment: Note that although gas vesicles are commonly referred to as 'vesicles' or 'vacuoles' in the literature, they are not surrounded by a membrane. synonym: "gas vesicle biosynthesis" NARROW [GOC:mah] synonym: "gas vesicle formation" NARROW [GOC:mah] synonym: "gas vesicle organisation" EXACT [GOC:curators] synonym: "gas vesicle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0031413 name: regulation of buoyancy namespace: biological_process def: "Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases." [GOC:mah, PATO:0001420] synonym: "buoyancy regulation" EXACT [] is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031414 name: N-terminal protein acetyltransferase complex namespace: cellular_component def: "A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule." [GOC:mah] synonym: "NAT complex" EXACT [] is_a: GO:0031248 ! protein acetyltransferase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031415 name: NatA complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins." [PMID:12890471] synonym: "N-terminal acetyltransferase A complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031416 name: NatB complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p." [PMID:12890471] synonym: "N-terminal acetyltransferase B complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031417 name: NatC complex namespace: cellular_component def: "A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p." [PMID:12890471] synonym: "N-terminal acetyltransferase C complex" EXACT [] is_a: GO:0031414 ! N-terminal protein acetyltransferase complex [Term] id: GO:0031418 name: L-ascorbic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species." [CHEBI:38290, GOC:mah] synonym: "L-ascorbate binding" EXACT [] synonym: "vitamin C binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0048029 ! monosaccharide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0031419 name: cobalamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:mah] synonym: "vitamin B12 binding" EXACT [] is_a: GO:0008144 ! drug binding is_a: GO:0019842 ! vitamin binding is_a: GO:0046906 ! tetrapyrrole binding is_a: GO:0048037 ! cofactor binding [Term] id: GO:0031420 name: alkali metal ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with any alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen." [GOC:mah] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0031421 name: invertasome namespace: cellular_component def: "A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts." [PMID:11114897, PMID:9732277] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031422 name: RecQ helicase-Topo III complex namespace: cellular_component def: "A complex containing a RecQ family helicase and a topoisomerase III homologue; may also include one or more additional proteins; conserved from E. coli to human." [PMID:15889139] synonym: "Sgs1-Top3 complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031423 name: hexon binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hexon, the major protein component of the icosahedral capsid of an adenovirus." [GOC:mah, PMID:12915569] is_a: GO:0005515 ! protein binding [Term] id: GO:0031424 name: keratinization namespace: biological_process def: "The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns." [GOC:dph, GOC:ebc, GOC:sdb_2009, GOC:tb] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0030216 ! keratinocyte differentiation [Term] id: GO:0031425 name: chloroplast RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules." [GOC:mah] is_a: GO:0006396 ! RNA processing [Term] id: GO:0031426 name: polycistronic mRNA processing namespace: biological_process def: "The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules." [GOC:mah] is_a: GO:0006397 ! mRNA processing [Term] id: GO:0031427 name: response to methotrexate namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase." [CHEBI:44185, GOC:ef, GOC:mah, ISBN:0198506732] is_a: GO:0001101 ! response to acid chemical is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0097327 ! response to antineoplastic agent is_a: GO:0097329 ! response to antimetabolite is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0031428 name: box C/D snoRNP complex namespace: cellular_component def: "A ribonucleoprotein complex containing small nucleolar RNA of the box C/D type that can carry out ribose-2'-O-methylation of target RNAs." [ISBN:0879695897, PMID:17284456] synonym: "box C/D small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm] synonym: "box C/D snoRNP ribose 2'-O methylase complex" EXACT [PMID:17284456] synonym: "box C/D snoRNP ribose-2'-O-methyltransferase complex" EXACT [PMID:17284456] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0031429 name: box H/ACA snoRNP complex namespace: cellular_component def: "A box H/ACA RNP complex that is located in the nucleolus." [GOC:vw, ISBN:0879695897, PMID:17284456, PMID:20227365] synonym: "box H/ACA small nucleolar ribonucleoprotein complex" EXACT [GOC:cjm] synonym: "box H/ACA snoRNP pseudouridylase complex" EXACT [GOC:mah, GOC:vw, PMID:17284456] is_a: GO:0044452 ! nucleolar part is_a: GO:0072588 ! box H/ACA RNP complex is_a: GO:1902494 ! catalytic complex [Term] id: GO:0031430 name: M band namespace: cellular_component def: "The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines." [GOC:mtg_muscle, ISBN:0198506732, ISBN:0815316194] synonym: "M disc" EXACT [] synonym: "M line" NARROW [] synonym: "mesophragma" EXACT [] synonym: "midline" BROAD [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0031431 name: Dbf4-dependent protein kinase complex namespace: cellular_component def: "A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins." [PMID:12045100] synonym: "Cdc7-Dbf4 complex" NARROW [] synonym: "DDK" EXACT [] synonym: "Hsk1-Dfp1 kinase complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0031432 name: titin binding namespace: molecular_function def: "Interacting selectively and non-covalently with titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031433 name: telethonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase." [GOC:mah, PMID:10481174] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0031434 name: mitogen-activated protein kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase, any protein that can phosphorylate a MAP kinase." [GOC:mah] synonym: "MAPKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031435 name: mitogen-activated protein kinase kinase kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mitogen-activated protein kinase kinase kinase, any protein that can phosphorylate a MAP kinase kinase." [GOC:bf] synonym: "MAPKKK binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0031436 name: BRCA1-BARD1 complex namespace: cellular_component def: "A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage." [PMID:12787778] is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0031437 name: regulation of mRNA cleavage namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] is_a: GO:0051252 ! regulation of RNA metabolic process relationship: regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031438 name: negative regulation of mRNA cleavage namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "down regulation of mRNA cleavage" EXACT [] synonym: "down-regulation of mRNA cleavage" EXACT [] synonym: "downregulation of mRNA cleavage" EXACT [] synonym: "inhibition of mRNA cleavage" NARROW [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031439 name: positive regulation of mRNA cleavage namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA cleavage." [GOC:mah] synonym: "activation of mRNA cleavage" NARROW [] synonym: "stimulation of mRNA cleavage" NARROW [] synonym: "up regulation of mRNA cleavage" EXACT [] synonym: "up-regulation of mRNA cleavage" EXACT [] synonym: "upregulation of mRNA cleavage" EXACT [] is_a: GO:0031437 ! regulation of mRNA cleavage is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0006379 ! mRNA cleavage [Term] id: GO:0031440 name: regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule." [GOC:mah] is_a: GO:0050684 ! regulation of mRNA processing relationship: regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031441 name: negative regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "down regulation of mRNA 3'-end processing" EXACT [] synonym: "down-regulation of mRNA 3'-end processing" EXACT [] synonym: "downregulation of mRNA 3'-end processing" EXACT [] synonym: "inhibition of mRNA 3'-end processing" NARROW [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050686 ! negative regulation of mRNA processing relationship: negatively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031442 name: positive regulation of mRNA 3'-end processing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mRNA 3'-end processing." [GOC:mah] synonym: "activation of mRNA 3'-end processing" NARROW [] synonym: "stimulation of mRNA 3'-end processing" NARROW [] synonym: "up regulation of mRNA 3'-end processing" EXACT [] synonym: "up-regulation of mRNA 3'-end processing" EXACT [] synonym: "upregulation of mRNA 3'-end processing" EXACT [] is_a: GO:0031440 ! regulation of mRNA 3'-end processing is_a: GO:0050685 ! positive regulation of mRNA processing relationship: positively_regulates GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0031443 name: fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "fast-twitch skeletal fiber contraction" EXACT [] synonym: "fast-twitch skeletal fibre contraction" EXACT [] synonym: "fast-twitch skeletal muscle fibre contraction" EXACT [] synonym: "fast-twitch skeletal myofiber contraction" EXACT [] synonym: "fast-twitch skeletal myofibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031444 name: slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue." [GOC:ef, GOC:mah, GOC:mtg_muscle] synonym: "slow-twitch skeletal muscle fibre contraction" EXACT [] is_a: GO:0014721 ! twitch skeletal muscle contraction [Term] id: GO:0031445 name: regulation of heterochromatin assembly namespace: biological_process def: "Any process that modulates the frequency, rate, extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of heterochromatin formation" EXACT [] is_a: GO:0010847 ! regulation of chromatin assembly relationship: regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031446 name: regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction relationship: regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031447 name: negative regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of fast-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031448 name: positive regulation of fast-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of fast-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of fast-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of fast-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of fast-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031446 ! regulation of fast-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0031443 ! fast-twitch skeletal muscle fiber contraction [Term] id: GO:0031449 name: regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0014724 ! regulation of twitch skeletal muscle contraction relationship: regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031450 name: negative regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "down regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "down-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "downregulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "inhibition of slow-twitch skeletal muscle contraction" NARROW [] synonym: "negative regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045988 ! negative regulation of striated muscle contraction relationship: negatively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031451 name: positive regulation of slow-twitch skeletal muscle fiber contraction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction." [GOC:dph, GOC:ef, GOC:mah, GOC:mtg_muscle, GOC:tb] synonym: "activation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "positive regulation of slow-twitch skeletal muscle contraction" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of slow-twitch skeletal muscle contraction" NARROW [] synonym: "up regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "up-regulation of slow-twitch skeletal muscle contraction" EXACT [] synonym: "upregulation of slow-twitch skeletal muscle contraction" EXACT [] is_a: GO:0031449 ! regulation of slow-twitch skeletal muscle fiber contraction is_a: GO:0045989 ! positive regulation of striated muscle contraction relationship: positively_regulates GO:0031444 ! slow-twitch skeletal muscle fiber contraction [Term] id: GO:0031452 name: negative regulation of heterochromatin assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "down regulation of heterochromatin formation" EXACT [] synonym: "down-regulation of heterochromatin formation" EXACT [] synonym: "downregulation of heterochromatin formation" EXACT [] synonym: "inhibition of heterochromatin formation" NARROW [] synonym: "negative regulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin assembly is_a: GO:0045798 ! negative regulation of chromatin assembly or disassembly relationship: negatively_regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031453 name: positive regulation of heterochromatin assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of heterochromatin formation." [GOC:mah] synonym: "activation of heterochromatin formation" NARROW [] synonym: "positive regulation of heterochromatin formation" EXACT [] synonym: "stimulation of heterochromatin formation" NARROW [] synonym: "up regulation of heterochromatin formation" EXACT [] synonym: "up-regulation of heterochromatin formation" EXACT [] synonym: "upregulation of heterochromatin formation" EXACT [] is_a: GO:0031445 ! regulation of heterochromatin assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0045799 ! positive regulation of chromatin assembly or disassembly relationship: positively_regulates GO:0031507 ! heterochromatin assembly [Term] id: GO:0031454 name: regulation of extent of heterochromatin assembly namespace: biological_process def: "Any process that modulates the extent or location of heterochromatin formation." [GOC:mah] synonym: "regulation of extent of heterochromatin formation" EXACT [] synonym: "regulation of heterochromatin spreading" RELATED [] is_a: GO:0031445 ! regulation of heterochromatin assembly [Term] id: GO:0031455 name: glycine betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine metabolism" EXACT [] synonym: "N-trimethylglycine metabolic process" EXACT [] synonym: "N-trimethylglycine metabolism" EXACT [] is_a: GO:0006577 ! amino-acid betaine metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0031456 name: glycine betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine anabolism" EXACT [] synonym: "glycine betaine biosynthesis" EXACT [] synonym: "glycine betaine formation" EXACT [] synonym: "glycine betaine synthesis" EXACT [] synonym: "N-trimethylglycine biosynthesis" EXACT [] synonym: "N-trimethylglycine biosynthetic process" EXACT [] is_a: GO:0006578 ! amino-acid betaine biosynthetic process is_a: GO:0031455 ! glycine betaine metabolic process [Term] id: GO:0031457 name: glycine betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine." [GOC:mah] synonym: "glycine betaine breakdown" EXACT [] synonym: "glycine betaine catabolism" EXACT [] synonym: "glycine betaine degradation" EXACT [] synonym: "N-trimethylglycine catabolic process" EXACT [] synonym: "N-trimethylglycine catabolism" EXACT [] is_a: GO:0006579 ! amino-acid betaine catabolic process is_a: GO:0031455 ! glycine betaine metabolic process [Term] id: GO:0031458 name: betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + a betaine(out) = ADP + phosphate + a betaine(in)." [GOC:mlg] synonym: "betaine ABC transporter" NARROW [] is_a: GO:0015199 ! amino-acid betaine transmembrane transporter activity is_a: GO:0031263 ! amine-transporting ATPase activity [Term] id: GO:0031459 name: glycine betaine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in)." [GOC:mlg] synonym: "glycine betaine ABC transporter" NARROW [] synonym: "N-trimethylglycine-transporting ATPase activity" EXACT [] xref: RHEA:32783 is_a: GO:0031458 ! betaine-transporting ATPase activity [Term] id: GO:0031460 name: glycine betaine transport namespace: biological_process def: "The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "N-trimethylglycine transport" EXACT [] is_a: GO:0015838 ! amino-acid betaine transport [Term] id: GO:0031461 name: cullin-RING ubiquitin ligase complex namespace: cellular_component def: "Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity." [PMID:15571813, PMID:15688063] synonym: "CRL complex" EXACT [] synonym: "cullin complex" EXACT [] synonym: "cullin-RING ligase" RELATED [] is_a: GO:0000151 ! ubiquitin ligase complex [Term] id: GO:0031462 name: Cul2-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CBC complex" BROAD [] synonym: "CDL2 complex" EXACT [] synonym: "CRL2 complex" EXACT [] synonym: "cullin-RING ligase 2" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "ECS complex" BROAD [] synonym: "SCF2 complex" RELATED [] synonym: "VBC complex" NARROW [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031463 name: Cul3-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein." [PMID:15571813, PMID:15688063] synonym: "BC3B complex" EXACT [] synonym: "BCR3 complex" EXACT [] synonym: "CDL3 complex" EXACT [] synonym: "CRL3 complex" EXACT [] synonym: "cullin-RING ligase 3" EXACT [] synonym: "SCF3 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031464 name: Cul4A-RING E3 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein." [PMID:15571813, PMID:15688063] synonym: "CDL4 complex" EXACT [] synonym: "CRL4 complex" EXACT [] synonym: "cullin-RING ligase 4A" EXACT [] synonym: "DCX complex" EXACT [] synonym: "SCF4 complex" RELATED [] synonym: "VDC complex" NARROW [] is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex [Term] id: GO:0031465 name: Cul4B-RING E3 ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits." [PMID:15571813, PMID:15688063] synonym: "cullin-RING ligase 4B" EXACT [] is_a: GO:0080008 ! Cul4-RING E3 ubiquitin ligase complex [Term] id: GO:0031466 name: Cul5-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein." [PMID:15571813, PMID:15688063] synonym: "CDL5 complex" EXACT [] synonym: "CRL5 complex" EXACT [] synonym: "cullin-RING ligase 5" EXACT [] synonym: "EC2S complex" BROAD [] synonym: "SCF5 complex" RELATED [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031467 name: Cul7-RING ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein." [PMID:15571813, PMID:15688063] synonym: "CDL7 complex" EXACT [] synonym: "CRL7 complex" EXACT [] synonym: "cullin-RING ligase 7" EXACT [] synonym: "SCF7 complex" EXACT [] is_a: GO:0031461 ! cullin-RING ubiquitin ligase complex [Term] id: GO:0031468 name: nuclear envelope reassembly namespace: biological_process def: "The reformation of the nuclear envelope following its breakdown in the context of a normal process." [GOC:mah] is_a: GO:0006998 ! nuclear envelope organization [Term] id: GO:0031469 name: polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] subset: goslim_pir is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0031470 name: carboxysome namespace: cellular_component def: "An organelle consisting of a proteinaceous coat and enzymes for the fixation of carbon dioxide including mechanisms for the concentration of carbonate to increase the efficiency of fixation under low-carbon dioxide conditions." [GOC:js, PMID:8157606, PMID:8491708] xref: Wikipedia:Carboxysome is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031471 name: ethanolamine degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase." [GOC:js, PMID:11844753] synonym: "ethanolamine metabolosome" RELATED [] is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031472 name: propanediol degradation polyhedral organelle namespace: cellular_component def: "An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase." [GOC:js, PMID:10498708, PMID:11844753, PMID:12923081] is_a: GO:0031469 ! polyhedral organelle [Term] id: GO:0031473 name: myosin III binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class III myosin; myosin III is monomeric and has an N terminal kinase domain." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031474 name: myosin IV complex namespace: cellular_component def: "A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031475 name: myosin V complex namespace: cellular_component def: "A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031476 name: myosin VI complex namespace: cellular_component def: "A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031477 name: myosin VII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031478 name: myosin VIII complex namespace: cellular_component def: "A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031479 name: myosin IX complex namespace: cellular_component def: "A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031480 name: myosin X complex namespace: cellular_component def: "A myosin complex containing one or more class X myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031481 name: myosin XI complex namespace: cellular_component def: "A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031482 name: myosin XII complex namespace: cellular_component def: "A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031483 name: myosin XIII complex namespace: cellular_component def: "A myosin complex containing one or more class XIII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031484 name: myosin XIV complex namespace: cellular_component def: "A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031485 name: myosin XV complex namespace: cellular_component def: "A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031486 name: myosin XVI complex namespace: cellular_component def: "A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html, PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031487 name: myosin XVII complex namespace: cellular_component def: "A myosin complex containing one or more class XVII myosin heavy chains and associated light chains." [http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031488 name: myosin XVIII complex namespace: cellular_component def: "A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain." [PMID:11294886] is_a: GO:0016461 ! unconventional myosin complex [Term] id: GO:0031489 name: myosin V binding namespace: molecular_function def: "Interacting selectively and non-covalently with a class V myosin; myosin V is a dimeric molecule involved in intracellular transport." [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] is_a: GO:0017022 ! myosin binding [Term] id: GO:0031490 name: chromatin DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA that is assembled into chromatin." [GOC:mah] is_a: GO:0003677 ! DNA binding is_a: GO:0003682 ! chromatin binding [Term] id: GO:0031491 name: nucleosome binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:mah] is_a: GO:0003682 ! chromatin binding is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0031492 name: nucleosomal DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA portion of a nucleosome." [GOC:mah] is_a: GO:0031490 ! chromatin DNA binding is_a: GO:0031491 ! nucleosome binding [Term] id: GO:0031493 name: nucleosomal histone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a histone that is assembled into a nucleosome." [GOC:mah] is_a: GO:0031491 ! nucleosome binding is_a: GO:0042393 ! histone binding [Term] id: GO:0031494 name: regulation of mating type switching namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [GOC:mah] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:2000241 ! regulation of reproductive process relationship: regulates GO:0007533 ! mating type switching [Term] id: GO:0031495 name: negative regulation of mating type switching namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "down regulation of mating type switching" EXACT [] synonym: "down-regulation of mating type switching" EXACT [] synonym: "downregulation of mating type switching" EXACT [] synonym: "inhibition of mating type switching" NARROW [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:2000242 ! negative regulation of reproductive process relationship: negatively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031496 name: positive regulation of mating type switching namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mating type switching." [GOC:mah] synonym: "activation of mating type switching" NARROW [] synonym: "stimulation of mating type switching" NARROW [] synonym: "up regulation of mating type switching" EXACT [] synonym: "up-regulation of mating type switching" EXACT [] synonym: "upregulation of mating type switching" EXACT [] is_a: GO:0010455 ! positive regulation of cell fate commitment is_a: GO:0031494 ! regulation of mating type switching is_a: GO:2000243 ! positive regulation of reproductive process relationship: positively_regulates GO:0007533 ! mating type switching [Term] id: GO:0031497 name: chromatin assembly namespace: biological_process def: "The assembly of DNA, histone proteins, other associated proteins, and sometimes RNA, into chromatin structure, beginning with the formation of the basic unit, the nucleosome, followed by organization of the nucleosomes into higher order structures, ultimately giving rise to a complex organization of specific domains within the nucleus." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] synonym: "establishment of chromatin architecture" EXACT [GOC:mah] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0006323 ! DNA packaging [Term] id: GO:0031498 name: chromatin disassembly namespace: biological_process def: "The controlled breakdown of chromatin from a higher order structure into its simpler subcomponents, DNA, histones, other proteins, and sometimes RNA." [http://www.infobiogen.fr/services/chromcancer/IntroItems/ChromatinEducEng.html, PMID:20404130] is_a: GO:0006333 ! chromatin assembly or disassembly is_a: GO:0022411 ! cellular component disassembly [Term] id: GO:0031499 name: TRAMP complex namespace: cellular_component def: "A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control." [PMID:15173578, PMID:15828860, PMID:15935758, PMID:15935759, PMID:16373491, PMID:16374505, PMID:16431988, PMID:16973437, PMID:17410208, PMID:17652137] synonym: "TRAMP4 complex" NARROW [] synonym: "TRAMP5 complex" NARROW [] synonym: "Trf4 complex" NARROW [] synonym: "Trf4 poly(A) polymerase complex" NARROW [] synonym: "Trf4p-Air2p-Mtr4p polyadenylation complex" NARROW [] xref: Wikipedia:TRAMP_complex is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031500 name: Tea1 cell-end complex namespace: cellular_component def: "A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity." [PMID:15936270] is_a: GO:0005875 ! microtubule associated complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0000133 ! polarisome [Term] id: GO:0031501 name: mannosyltransferase complex namespace: cellular_component def: "A complex that posseses mannosyltransferase activity." [GOC:mah] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0031502 name: dolichyl-phosphate-mannose-protein mannosyltransferase complex namespace: cellular_component def: "A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies." [GOC:mah, GOC:pr, PMID:15948957] comment: Note that GO:0004169 'dolichyl-phosphate-mannose-protein mannosyltransferase activity' (part of protein O-linked mannosylation) has never been observed in green plants. However, N- and C-mannosylation may occur in these species; see figure 1 in PMID:21558543. synonym: "PMT family mannosyltransferase complex" RELATED [] synonym: "protein O-mannosyltransferase complex" EXACT [] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0031503 name: protein-containing complex localization namespace: biological_process def: "A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location." [GOC:mah] synonym: "establishment and maintenance of protein complex localization" EXACT [] synonym: "protein complex localisation" EXACT [GOC:mah] synonym: "protein complex localization" RELATED [] is_a: GO:0008104 ! protein localization [Term] id: GO:0031504 name: peptidoglycan-based cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] synonym: "peptidoglycan-based cell wall organisation" EXACT [GOC:mah] synonym: "peptidoglycan-based cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071555 ! cell wall organization [Term] id: GO:0031505 name: fungal-type cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall." [GOC:dph, GOC:jl, GOC:mah, GOC:mtg_sensu] synonym: "beta-glucan-containing cell wall organization and biogenesis" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall organisation" NARROW [] synonym: "chitin- and beta-glucan-containing cell wall organization and biogenesis" NARROW [] synonym: "chitin-containing cell wall organization and biogenesis" RELATED [] synonym: "fungal-type cell wall organization and biogenesis" RELATED [] is_a: GO:0071555 ! cell wall organization is_a: GO:0071852 ! fungal-type cell wall organization or biogenesis [Term] id: GO:0031506 name: cell wall glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues." [GOC:mah] synonym: "cell wall glycoprotein anabolism" EXACT [] synonym: "cell wall glycoprotein biosynthesis" EXACT [] synonym: "cell wall glycoprotein formation" EXACT [] synonym: "cell wall glycoprotein synthesis" EXACT [] is_a: GO:0009101 ! glycoprotein biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process [Term] id: GO:0031507 name: heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin, a compact and highly condensed form that is often, but not always, transcriptionally silent." [GOC:mah] synonym: "establishment of heterochromatin architecture" EXACT [GOC:mah] synonym: "heterochromatin formation" EXACT [] is_a: GO:0006338 ! chromatin remodeling is_a: GO:0031497 ! chromatin assembly is_a: GO:0070828 ! heterochromatin organization [Term] id: GO:0031508 name: pericentric heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156] synonym: "centric heterochromatin formation" RELATED [] synonym: "centromeric heterochromatin biosynthesis" EXACT [] synonym: "centromeric heterochromatin formation" EXACT [] is_a: GO:0031055 ! chromatin remodeling at centromere is_a: GO:0031507 ! heterochromatin assembly relationship: part_of GO:0034508 ! centromere complex assembly [Term] id: GO:0031509 name: telomeric heterochromatin assembly namespace: biological_process def: "The assembly of chromatin into heterochromatin at the telomere." [GOC:mah] synonym: "telomeric heterochromatin formation" EXACT [] is_a: GO:0031507 ! heterochromatin assembly relationship: part_of GO:0032200 ! telomere organization [Term] id: GO:0031510 name: SUMO activating enzyme complex namespace: cellular_component def: "A conserved heterodimeric complex with SUMO activating enzyme activity." [PMID:15601841] synonym: "SAE" EXACT [] synonym: "SUMO E1 activator enzyme complex" EXACT [] is_a: GO:0044428 ! nuclear part is_a: GO:1902494 ! catalytic complex [Term] id: GO:0031511 name: Mis6-Sim4 complex namespace: cellular_component def: "A protein complex that forms part of the inner centromere, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human." [GOC:vw, PMID:12719471, PMID:15897182] synonym: "Mis6 centromere subcomplex" NARROW [] synonym: "Mis6-Mal2-Sim4 centromere complex" EXACT [GOC:vw, PMID:21445296] synonym: "Sim4 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000939 ! condensed chromosome inner kinetochore [Term] id: GO:0031514 name: motile cilium namespace: cellular_component alt_id: GO:0009434 alt_id: GO:0031512 def: "A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell." [GOC:cilia, GOC:dgh, GOC:kmv, PMID:17009929, PMID:20144998, PMID:22118931] synonym: "microtubule-based flagellum" RELATED [] synonym: "motile cilia" EXACT [GOC:curators] synonym: "motile primary cilia" RELATED [GOC:curators] synonym: "motile primary cilium" RELATED [] synonym: "motile secondary cilium" RELATED [GOC:curators] synonym: "nodal cilium" RELATED [GOC:curators] is_a: GO:0005929 ! cilium [Term] id: GO:0031515 name: tRNA (m1A) methyltransferase complex namespace: cellular_component def: "A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer." [PMID:10779558, PMID:14739239] is_a: GO:0043527 ! tRNA methyltransferase complex [Term] id: GO:0031516 name: far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity [Term] id: GO:0031517 name: red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation." [GOC:nln] is_a: GO:0009883 ! red or far-red light photoreceptor activity [Term] id: GO:0031518 name: CBF3 complex namespace: cellular_component def: "A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p." [PMID:13679521, PMID:9407032] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0031519 name: PcG protein complex namespace: cellular_component def: "A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure." [PMID:9372908] subset: goslim_pir synonym: "Polycomb Group protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031520 name: plasma membrane of cell tip namespace: cellular_component def: "The portion of the plasma membrane surrounding the cell tip." [GOC:mah] is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0051286 ! cell tip [Term] id: GO:0031521 name: spitzenkorper namespace: cellular_component def: "Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments." [PMID:15701784, PMID:15976451] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part relationship: part_of GO:0001411 ! hyphal tip relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0031522 name: cell envelope Sec protein transport complex namespace: cellular_component def: "A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC." [GOC:mtg_sensu, PMID:15223057] comment: Note that this term represents the protein complex involved in transport of proteins across the cytoplasmic membrane. For proteins involved in bacterial type II secretion across the outer membrane, consider annotating to 'type II protein secretion complex ; GO:0015628'. For proteins involved in Sec-complex dependent translocation into the eukaryotic endoplasmic reticulum, consider annotating to 'endoplasmic reticulum Sec complex ; GO:0031205'. synonym: "plasma membrane Sec complex" RELATED [] synonym: "Sec complex" BROAD [] synonym: "Sec secretion complex" NARROW [] synonym: "Sec translocation complex" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0031523 name: Myb complex namespace: cellular_component def: "A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression." [PMID:12490953, PMID:15545624] synonym: "Myeloblastosis proto-oncogene protein complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0031524 name: menthol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] synonym: "menthol metabolism" EXACT [] is_a: GO:0016098 ! monoterpenoid metabolic process is_a: GO:0017144 ! drug metabolic process is_a: GO:1902652 ! secondary alcohol metabolic process [Term] id: GO:0031525 name: menthol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol." [GOC:mah] synonym: "menthol anabolism" EXACT [] synonym: "menthol biosynthesis" EXACT [] synonym: "menthol formation" EXACT [] synonym: "menthol synthesis" EXACT [] is_a: GO:0016099 ! monoterpenoid biosynthetic process is_a: GO:0031524 ! menthol metabolic process is_a: GO:1902653 ! secondary alcohol biosynthetic process [Term] id: GO:0031526 name: brush border membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding the brush border." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005903 ! brush border [Term] id: GO:0031527 name: filopodium membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a filopodium." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0031528 name: microvillus membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a microvillus." [GOC:mah] is_a: GO:0031253 ! cell projection membrane relationship: part_of GO:0005902 ! microvillus [Term] id: GO:0031529 name: ruffle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell." [GOC:mah, PMID:10036235] synonym: "ruffle organisation" EXACT [GOC:mah] synonym: "ruffle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0031530 name: gonadotropin-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary." [GOC:pr, PMID:15196882] synonym: "GnRH receptor binding" EXACT [] synonym: "gonadotrophin-releasing hormone receptor binding" EXACT [GOC:dph] is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031531 name: thyrotropin-releasing hormone receptor binding namespace: molecular_function alt_id: GO:0031888 def: "Interacting selectively and non-covalently with a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary." [PMID:8592728] synonym: "thyrotropin releasing hormone receptor binding" EXACT [] synonym: "thyrotropin-releasing hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0051428 ! peptide hormone receptor binding [Term] id: GO:0031532 name: actin cytoskeleton reorganization namespace: biological_process alt_id: GO:0007012 def: "A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:ecd, GOC:mah] synonym: "actin cytoskeleton remodeling" EXACT [] synonym: "actin cytoskeleton reorganisation" EXACT [GOC:curators] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0031533 name: mRNA cap methyltransferase complex namespace: cellular_component def: "A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping." [GOC:vw, PMID:10347220] synonym: "mRNA (guanine-N7) methyltransferase complex" EXACT [] synonym: "mRNA capping enzyme complex" EXACT [GOC:vw] is_a: GO:0034708 ! methyltransferase complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0031534 name: minus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031535 name: plus-end directed microtubule sliding namespace: biological_process def: "The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules." [GOC:mah, GOC:vw] is_a: GO:0051012 ! microtubule sliding [Term] id: GO:0031536 name: positive regulation of exit from mitosis namespace: biological_process def: "Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:mah] synonym: "activation of exit from mitosis" NARROW [] synonym: "stimulation of exit from mitosis" NARROW [] synonym: "up regulation of exit from mitosis" EXACT [] synonym: "up-regulation of exit from mitosis" EXACT [] synonym: "upregulation of exit from mitosis" EXACT [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0045840 ! positive regulation of mitotic nuclear division is_a: GO:1901992 ! positive regulation of mitotic cell cycle phase transition relationship: positively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0031537 name: regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process relationship: regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031538 name: negative regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin metabolic process" EXACT [] synonym: "down-regulation of anthocyanin metabolic process" EXACT [] synonym: "downregulation of anthocyanin metabolic process" EXACT [] synonym: "inhibition of anthocyanin metabolic process" NARROW [] synonym: "negative regulation of anthocyanin metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: negatively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031539 name: positive regulation of anthocyanin metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins." [GOC:mah] synonym: "activation of anthocyanin metabolic process" NARROW [] synonym: "positive regulation of anthocyanin metabolism" EXACT [] synonym: "stimulation of anthocyanin metabolic process" NARROW [] synonym: "up regulation of anthocyanin metabolic process" EXACT [] synonym: "up-regulation of anthocyanin metabolic process" EXACT [] synonym: "upregulation of anthocyanin metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: positively_regulates GO:0046283 ! anthocyanin-containing compound metabolic process [Term] id: GO:0031540 name: regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "regulation of anthocyanin anabolism" EXACT [] synonym: "regulation of anthocyanin biosynthesis" EXACT [] synonym: "regulation of anthocyanin formation" EXACT [] synonym: "regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031537 ! regulation of anthocyanin metabolic process relationship: regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031541 name: negative regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "down regulation of anthocyanin biosynthetic process" EXACT [] synonym: "down-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "downregulation of anthocyanin biosynthetic process" EXACT [] synonym: "inhibition of anthocyanin biosynthetic process" NARROW [] synonym: "negative regulation of anthocyanin anabolism" EXACT [] synonym: "negative regulation of anthocyanin biosynthesis" EXACT [] synonym: "negative regulation of anthocyanin formation" EXACT [] synonym: "negative regulation of anthocyanin synthesis" EXACT [] is_a: GO:0009964 ! negative regulation of flavonoid biosynthetic process is_a: GO:0031538 ! negative regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process relationship: negatively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031542 name: positive regulation of anthocyanin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins." [GOC:mah] synonym: "activation of anthocyanin biosynthetic process" NARROW [] synonym: "positive regulation of anthocyanin anabolism" EXACT [] synonym: "positive regulation of anthocyanin biosynthesis" EXACT [] synonym: "positive regulation of anthocyanin formation" EXACT [] synonym: "positive regulation of anthocyanin synthesis" EXACT [] synonym: "stimulation of anthocyanin biosynthetic process" NARROW [] synonym: "up regulation of anthocyanin biosynthetic process" EXACT [] synonym: "up-regulation of anthocyanin biosynthetic process" EXACT [] synonym: "upregulation of anthocyanin biosynthetic process" EXACT [] is_a: GO:0009963 ! positive regulation of flavonoid biosynthetic process is_a: GO:0031539 ! positive regulation of anthocyanin metabolic process is_a: GO:0031540 ! regulation of anthocyanin biosynthetic process relationship: positively_regulates GO:0009718 ! anthocyanin-containing compound biosynthetic process [Term] id: GO:0031543 name: peptidyl-proline dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2." [GOC:mah, GOC:vw, PMID:24550447, PMID:24550462] synonym: "proline hydroxylase activity" BROAD [GOC:krc, GOC:pr] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [GOC:krc, GOC:pr] synonym: "prolyl 4-hydroxylase activity" BROAD [GOC:krc, GOC:pr] synonym: "prolyl hydroxylase activity" BROAD [GOC:krc, GOC:pr] is_a: GO:0016706 ! 2-oxoglutarate-dependent dioxygenase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0031544 name: peptidyl-proline 3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2." [GOC:mah] is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031545 name: peptidyl-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2." [GOC:mah] synonym: "HIF-type prolyl 4-hydroxylase" NARROW [] synonym: "prolyl 4-hydroxylase" BROAD [] xref: reactome:R-HSA-1234165 "Nuclear PHD1,3 hydroxylates proline residues on HIF3A" xref: reactome:R-HSA-1234166 "Nuclear PHD1,3 hydroxylates proline residues on EPAS1 (HIF2A)" xref: reactome:R-HSA-1234173 "Cytosolic PHD2,3 hydroxylates proline residues on HIF3A" xref: reactome:R-HSA-1234177 "Cytosolic PHD2,3 hydroxylates proline residues on HIF1A" xref: reactome:R-HSA-1234179 "Cytosolic PHD2,3 hydroxylates proline residues on EPAS1 (HIF2A)" xref: reactome:R-HSA-1234181 "Nuclear PHD1,3 hydroxylates proline residues on HIF1A" is_a: GO:0031543 ! peptidyl-proline dioxygenase activity [Term] id: GO:0031546 name: brain-derived neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the brain-derived neurotrophic factor receptor." [GOC:mah] synonym: "BDNF receptor binding" EXACT [] synonym: "brain-derived neurotrophic factor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0031547 name: brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands." [GOC:mah] synonym: "BDNF receptor signaling pathway" EXACT [] synonym: "BDNF signalling pathway" EXACT [] synonym: "brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0031548 name: regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "regulation of BDNF receptor signaling pathway" EXACT [] synonym: "regulation of BDNF receptor signalling pathway" EXACT [] synonym: "regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction relationship: regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031549 name: negative regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "negative regulation of BDNF receptor signaling pathway" EXACT [] synonym: "negative regulation of BDNF receptor signalling pathway" EXACT [] synonym: "negative regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway relationship: negatively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031550 name: positive regulation of brain-derived neurotrophic factor receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "positive regulation of BDNF receptor signaling pathway" EXACT [] synonym: "positive regulation of BDNF receptor signalling pathway" EXACT [] synonym: "positive regulation of brain-derived neurotrophic factor receptor signalling pathway" EXACT [] synonym: "stimulation of brain-derived neurotrophic factor receptor signaling pathway" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor signaling pathway" EXACT [] is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway relationship: positively_regulates GO:0031547 ! brain-derived neurotrophic factor receptor signaling pathway [Term] id: GO:0031551 name: regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "regulation of BDNF receptor activity" EXACT [] synonym: "regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0010469 ! regulation of signaling receptor activity is_a: GO:0031548 ! regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity is_a: GO:0090287 ! regulation of cellular response to growth factor stimulus [Term] id: GO:0031552 name: negative regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "down regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "down-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "downregulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "inhibition of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "negative regulation of BDNF receptor activity" EXACT [] synonym: "negative regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] is_a: GO:0031549 ! negative regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity is_a: GO:0090288 ! negative regulation of cellular response to growth factor stimulus is_a: GO:2000272 ! negative regulation of signaling receptor activity [Term] id: GO:0031553 name: positive regulation of brain-derived neurotrophic factor-activated receptor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity." [GOC:mah] synonym: "activation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "positive regulation of BDNF receptor activity" EXACT [] synonym: "positive regulation of brain-derived neurotrophic factor receptor activity" EXACT [GOC:bf, GOC:signaling] synonym: "stimulation of brain-derived neurotrophic factor receptor activity" NARROW [] synonym: "up regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "up-regulation of brain-derived neurotrophic factor receptor activity" EXACT [] synonym: "upregulation of brain-derived neurotrophic factor receptor activity" EXACT [] is_a: GO:0031550 ! positive regulation of brain-derived neurotrophic factor receptor signaling pathway is_a: GO:0031551 ! regulation of brain-derived neurotrophic factor-activated receptor activity is_a: GO:0061098 ! positive regulation of protein tyrosine kinase activity is_a: GO:2000273 ! positive regulation of signaling receptor activity [Term] id: GO:0031554 name: regulation of DNA-templated transcription, termination namespace: biological_process def: "Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [GOC:mlg, GOC:txnOH] synonym: "regulation of DNA-dependent transcription, termination" EXACT [GOC:txnOH] synonym: "regulation of termination of DNA-dependent transcription" EXACT [GOC:jh2] synonym: "regulation of transcription termination, DNA-dependent" EXACT [GOC:jh2] synonym: "transcription antiterminator activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0043244 ! regulation of protein complex disassembly relationship: regulates GO:0006353 ! DNA-templated transcription, termination [Term] id: GO:0031555 name: transcriptional attenuation namespace: biological_process def: "Regulation of transcription through variation in where transcription termination occurs." [GOC:dh, GOC:mlg, ISBN:0198542682] xref: Wikipedia:Attenuator_(genetics) is_a: GO:0031554 ! regulation of DNA-templated transcription, termination [Term] id: GO:0031556 name: transcriptional attenuation by ribosome namespace: biological_process def: "A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch." [GOC:dh, GOC:mlg, ISBN:0198542682] synonym: "ribosome-mediated transcriptional attenuation" EXACT [GOC:dph, GOC:tb] is_a: GO:0031555 ! transcriptional attenuation [Term] id: GO:0031557 name: obsolete induction of programmed cell death in response to chemical stimulus namespace: biological_process def: "OBSOLETE. A process which directly activates any of the steps required for programmed cell death as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0012501 programmed cell death. synonym: "induction of programmed cell death in response to chemical stimulus" EXACT [] synonym: "induction of programmed cell death in response to chemical substance" EXACT [] is_obsolete: true [Term] id: GO:0031558 name: obsolete induction of apoptosis in response to chemical stimulus namespace: biological_process def: "OBSOLETE. Any process that directly activates any of the steps required for cell death by apoptosis as a result of a chemical stimulus." [GOC:mah, GOC:mtg_apoptosis] comment: This term was made obsolete because it is now superseded by better defined and more specific terms under the node of GO:0006915 apoptotic process. synonym: "induction of apoptosis in response to chemical stimulus" EXACT [] synonym: "induction of apoptosis in response to chemical substance" EXACT [] is_obsolete: true [Term] id: GO:0031559 name: oxidosqualene cyclase activity namespace: molecular_function def: "Catalysis of the cyclization of (S)-2,3-epoxysqualene to form a triterpene." [GOC:ct] comment: Note that the phrase 'oxidosqualene cyclase' has been used to refer to enzymes that catalyze the reaction represented by 'lanosterol synthase activity ; GO:0000250'. synonym: "2,3-oxidosqualene cyclase activity" EXACT [GOC:mah] is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0031560 name: cellular bud neck polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis." [PMID:9632790] is_a: GO:0000133 ! polarisome relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0031561 name: cellular bud tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud." [PMID:9632790] is_a: GO:0000133 ! polarisome relationship: part_of GO:0005934 ! cellular bud tip [Term] id: GO:0031562 name: hyphal tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha." [PMID:15976451] is_a: GO:0000133 ! polarisome relationship: part_of GO:0001411 ! hyphal tip [Term] id: GO:0031563 name: mating projection tip polarisome namespace: cellular_component def: "Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone." [PMID:14734532] is_a: GO:0000133 ! polarisome is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0043332 ! mating projection tip [Term] id: GO:0031564 name: transcription antitermination namespace: biological_process def: "Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s)." [ISBN:0198577788, PMID:12456320] synonym: "transcriptional readthrough" EXACT [] is_a: GO:0031554 ! regulation of DNA-templated transcription, termination [Term] id: GO:0031565 name: obsolete cytokinesis checkpoint namespace: biological_process alt_id: GO:0000135 def: "OBSOLETE. A mitotic cell cycle checkpoint that detects a defect in cytokinesis and negatively regulates G2/M transition." [GOC:mtg_cell_cycle] comment: The reason this term was made obsolete is that the two terms cytokinesis checkpoint (GO:0031565) and cytokinesis after mitosis (GO:0000078) were conflated in meaning. synonym: "contractile ring checkpoint" EXACT [] synonym: "septin checkpoint" EXACT [] is_obsolete: true consider: GO:0044878 consider: GO:0044879 [Term] id: GO:0031566 name: actomyosin contractile ring maintenance namespace: biological_process def: "The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb, GOC:vw] synonym: "contractile ring maintenance involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "cytokinesis, contractile ring maintenance, involved in cytokinesis during cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0036212 ! contractile ring maintenance is_a: GO:0044837 ! actomyosin contractile ring organization [Term] id: GO:0031567 name: mitotic cell size control checkpoint namespace: biological_process def: "The mitotic cell cycle checkpoint that delays or arrests cell cycle progression until cells have reached a critical size." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle cell size control checkpoint" EXACT [GOC:mah] is_a: GO:0007093 ! mitotic cell cycle checkpoint relationship: part_of GO:0008361 ! regulation of cell size [Term] id: GO:0031568 name: G1 cell size control checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G1 and S phase until a critical size is reached." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition size control checkpoint" EXACT [] synonym: "mitotic G1 cell size control checkpoint" EXACT [] is_a: GO:0031567 ! mitotic cell size control checkpoint is_a: GO:2000134 ! negative regulation of G1/S transition of mitotic cell cycle [Term] id: GO:0031569 name: mitotic G2 cell size control checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that monitors cell size, and negatively regulates cell cycle progression between G2 and M phase until a critical size is reached." [GOC:mtg_cell_cycle] synonym: "G2 cell size control checkpoint" EXACT [] synonym: "G2/M transition size control checkpoint" EXACT [] synonym: "mitotic cell cycle G2/M transition size control checkpoint" EXACT [GOC:mah] is_a: GO:0010972 ! negative regulation of G2/M transition of mitotic cell cycle is_a: GO:0031567 ! mitotic cell size control checkpoint [Term] id: GO:0031570 name: DNA integrity checkpoint namespace: biological_process def: "A cell cycle process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes." [GOC:mtg_cell_cycle] is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031571 name: mitotic G1 DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G1/S transition of the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] synonym: "mitotic cell cycle G1/S transition DNA damage checkpoint" EXACT [] is_a: GO:0044773 ! mitotic DNA damage checkpoint is_a: GO:0044783 ! G1 DNA damage checkpoint is_a: GO:0044819 ! mitotic G1/S transition checkpoint [Term] id: GO:0031572 name: G2 DNA damage checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects and negatively regulates progression from G2 to M phase in the cell cycle in response to DNA damage." [GOC:mtg_cell_cycle] comment: Note that this term should only be used as a grouping term for the mitotic and meiotic G2 DNA damage checkpoints, and should not be used for direct manual annotation. You should always be able to choose one of its child terms instead. subset: gocheck_do_not_manually_annotate synonym: "G2/M transition DNA damage checkpoint" EXACT [] is_a: GO:0000077 ! DNA damage checkpoint [Term] id: GO:0031573 name: intra-S DNA damage checkpoint namespace: biological_process def: "A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression." [GOC:vw] synonym: "mitotic intra-S DNA damage checkpoint" EXACT [] synonym: "S-phase checkpoint" BROAD [] is_a: GO:0044773 ! mitotic DNA damage checkpoint [Term] id: GO:0031577 name: spindle checkpoint namespace: biological_process def: "A cell cycle checkpoint that originates from the mitotic or meiotic spindle." [GOC:mtg_cell_cycle] comment: Note that this term should not be used for direct manual annotation as it should always be possible to choose either a mitotic or meiotic child term. subset: gocheck_do_not_manually_annotate xref: Wikipedia:Spindle_checkpoint is_a: GO:0000075 ! cell cycle checkpoint [Term] id: GO:0031578 name: mitotic spindle orientation checkpoint namespace: biological_process def: "A cell cycle checkpoint that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected." [GOC:mtg_cell_cycle, PMID:14616062] synonym: "mitotic cell cycle spindle orientation checkpoint" EXACT [] synonym: "SOC" EXACT [] synonym: "spindle position checkpoint" EXACT [] synonym: "SPOC" EXACT [] is_a: GO:0001100 ! negative regulation of exit from mitosis is_a: GO:0071174 ! mitotic spindle checkpoint [Term] id: GO:0031579 name: membrane raft organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:dph, GOC:jl, GOC:mah] synonym: "lipid raft organization" EXACT [GOC:mah] synonym: "membrane raft organisation" EXACT [GOC:mah] synonym: "membrane raft organization and biogenesis" RELATED [GOC:mah] is_a: GO:0061024 ! membrane organization [Term] id: GO:0031580 name: membrane raft distribution namespace: biological_process def: "The process that establishes the spatial arrangement of membrane rafts within a cellular membrane." [GOC:mah] synonym: "lipid raft distribution" EXACT [] is_a: GO:0031579 ! membrane raft organization is_a: GO:0051665 ! membrane raft localization [Term] id: GO:0031581 name: hemidesmosome assembly namespace: biological_process def: "Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina." [GOC:dgh, PMID:15983403] is_a: GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0031582 name: replication fork arrest at rDNA repeats namespace: biological_process def: "A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer." [GOC:mah, GOC:vw] synonym: "replication fork arrest at ribosomal DNA repeats" EXACT [] synonym: "replication fork blocking at rDNA repeats" EXACT [] is_a: GO:0043007 ! maintenance of rDNA is_a: GO:0043111 ! replication fork arrest [Term] id: GO:0031583 name: phospholipase D-activating G protein-coupled receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of phospholipase D (PLD) and a subsequent increase in cellular levels of phosphatidic acid (PA)." [GOC:mah, GOC:signaling, PMID:11812783, PMID:15924269] comment: This term is intended to cover steps in a GPCR signaling pathway both upstream and downstream of phospholipase D (PLD) activation. synonym: "activation of phospholipase D activity by G-protein coupled receptor protein signaling pathway" RELATED [GOC:signaling] synonym: "G-protein signalling, phospholipase D activating pathway" EXACT [] synonym: "phospholipase D-activating G-protein coupled receptor signaling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0031584 name: activation of phospholipase D activity namespace: biological_process def: "Any process that initiates the activity of inactive phospholipase D." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0010518 ! positive regulation of phospholipase activity [Term] id: GO:0031585 name: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "regulation of inositol-1,4,5-triphosphate receptor activity" EXACT [GOC:signaling] synonym: "regulation of IP3 receptor activity" EXACT [GOC:dph] is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0051279 ! regulation of release of sequestered calcium ion into cytosol is_a: GO:1901019 ! regulation of calcium ion transmembrane transporter activity is_a: GO:2001257 ! regulation of cation channel activity [Term] id: GO:0031586 name: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "down regulation of IP3 receptor activity" EXACT [] synonym: "down-regulation of IP3 receptor activity" EXACT [] synonym: "downregulation of IP3 receptor activity" EXACT [] synonym: "inhibition of IP3 receptor activity" NARROW [] synonym: "negative regulation of inositol 1,4,5-trisphosphate receptor activity" EXACT [GOC:signaling] synonym: "negative regulation of IP3 receptor activity" RELATED [GOC:dph] is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity is_a: GO:0050849 ! negative regulation of calcium-mediated signaling is_a: GO:0051280 ! negative regulation of release of sequestered calcium ion into cytosol is_a: GO:1901020 ! negative regulation of calcium ion transmembrane transporter activity is_a: GO:2001258 ! negative regulation of cation channel activity [Term] id: GO:0031587 name: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel." [GOC:dph, GOC:mah, GOC:signaling] synonym: "activation of IP3 receptor activity" NARROW [] synonym: "positive regulation of inositol-1,4,5-trisphosphate receptor activity" EXACT [GOC:bf] synonym: "positive regulation of IP3 receptor activity" EXACT [GOC:dph] synonym: "stimulation of IP3 receptor activity" NARROW [] synonym: "up regulation of IP3 receptor activity" EXACT [] synonym: "up-regulation of IP3 receptor activity" EXACT [] synonym: "upregulation of IP3 receptor activity" EXACT [] is_a: GO:0031585 ! regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity is_a: GO:0050850 ! positive regulation of calcium-mediated signaling is_a: GO:0051281 ! positive regulation of release of sequestered calcium ion into cytosol is_a: GO:1901021 ! positive regulation of calcium ion transmembrane transporter activity is_a: GO:2001259 ! positive regulation of cation channel activity [Term] id: GO:0031588 name: nucleotide-activated protein kinase complex namespace: cellular_component def: "A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae)." [GOC:bhm, GOC:mah, GOC:vw] synonym: "5'-AMP-activated protein kinase complex" NARROW [] synonym: "ADP-activated protein kinase complex" NARROW [] synonym: "AMP-activated protein kinase complex" NARROW [] synonym: "AMPK complex" RELATED [] synonym: "Snf1 kinase complex" NARROW [] synonym: "Snf1 serine/threonine protein kinase complex" NARROW [] synonym: "SNF1/AMPK protein kinase complex" NARROW [] is_a: GO:0044424 ! intracellular part is_a: GO:1902911 ! protein kinase complex [Term] id: GO:0031589 name: cell-substrate adhesion namespace: biological_process def: "The attachment of a cell to the underlying substrate via adhesion molecules." [GOC:mah, GOC:pf] is_a: GO:0007155 ! cell adhesion [Term] id: GO:0031590 name: wybutosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:mah, RNAmods:037] synonym: "wybutosine metabolism" EXACT [] synonym: "yW metabolic process" EXACT [] synonym: "yW metabolism" EXACT [] is_a: GO:1901564 ! organonitrogen compound metabolic process is_a: GO:1901657 ! glycosyl compound metabolic process [Term] id: GO:0031591 name: wybutosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules." [GOC:hjd, GOC:mah, RNAmods:037] comment: Note that wybutosine is a hypermodified G-residue, formerly called the Y-base, and its derivatives are exclusively found at position 37 (anticodon loop) of tRNAPhe. synonym: "yW biosynthesis" EXACT [] synonym: "yW biosynthetic process" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0031590 ! wybutosine metabolic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process is_a: GO:1901659 ! glycosyl compound biosynthetic process [Term] id: GO:0031592 name: centrosomal corona namespace: cellular_component def: "An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin." [GOC:kp, GOC:mah] comment: Note that the centrosomal corona has been observed in Dictyostelium, and is the functional equivalent of pericentriolar material. is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0031593 name: polyubiquitin modification-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein upon poly-ubiquitination of the target protein." [GOC:pg] is_a: GO:0140030 ! modification-dependent protein binding [Term] id: GO:0031594 name: neuromuscular junction namespace: cellular_component def: "The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential." [GOC:nln] comment: In vertebrates, the term 'neuromuscular junction' is limited to synapses targeting skeletal muscle fibers - all of which are cholinergic and excitatory. Both inhibitory and excitatory neuromuscular junctions exist in invertebrates, utilizing a range of neurotransmitters including glutamate, GABA and 5-HT. synonym: "motor endplate" RELATED [NIF_Subcellular:nlx_subcell_20090512] synonym: "NMJ" RELATED [GOC:ha] xref: NIF_Subcellular:sao1124888485 xref: Wikipedia:Neuromuscular_junction is_a: GO:0045202 ! synapse [Term] id: GO:0031595 name: nuclear proteasome complex namespace: cellular_component def: "A proteasome found in the nucleus of a cell." [GOC:mah] is_a: GO:0000502 ! proteasome complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0031596 name: obsolete ER proteasome complex namespace: cellular_component def: "OBSOLETE. A proteasome found in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031597 name: cytosolic proteasome complex namespace: cellular_component def: "A proteasome complex found in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0000502 ! proteasome complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0031598 name: nuclear proteasome regulatory particle namespace: cellular_component def: "The regulatory subcomplex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005838 ! proteasome regulatory particle is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031599 name: obsolete ER proteasome regulatory particle namespace: cellular_component def: "OBSOLETE. The regulatory subcomplex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031600 name: cytosolic proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005838 ! proteasome regulatory particle is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031601 name: nuclear proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0005839 ! proteasome core complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031595 ! nuclear proteasome complex [Term] id: GO:0031602 name: obsolete ER proteasome core complex namespace: cellular_component def: "OBSOLETE. The core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031603 name: cytosolic proteasome core complex namespace: cellular_component def: "The core complex of a proteasome located in the cytosol of a cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0005839 ! proteasome core complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031597 ! cytosolic proteasome complex [Term] id: GO:0031604 name: nuclear proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031605 name: obsolete ER proteasome core complex, alpha-subunit complex namespace: cellular_component def: "OBSOLETE. The subunits forming the outer ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031606 name: cytosolic proteasome core complex, alpha-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019773 ! proteasome core complex, alpha-subunit complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031607 name: nuclear proteasome core complex, beta-subunit complex namespace: cellular_component def: "The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031601 ! nuclear proteasome core complex [Term] id: GO:0031608 name: obsolete ER proteasome core complex, beta-subunit complex namespace: cellular_component def: "OBSOLETE. The subunits forming the inner ring of the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031609 name: cytosolic proteasome core complex, beta-subunit complex namespace: cellular_component def: "The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0019774 ! proteasome core complex, beta-subunit complex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031603 ! cytosolic proteasome core complex [Term] id: GO:0031610 name: nuclear proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031611 name: obsolete ER proteasome regulatory particle, base subcomplex namespace: cellular_component def: "OBSOLETE. The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031612 name: cytosolic proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008540 ! proteasome regulatory particle, base subcomplex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031613 name: nuclear proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell." [GOC:mah] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031598 ! nuclear proteasome regulatory particle [Term] id: GO:0031614 name: obsolete ER proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "OBSOLETE. The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the endoplasmic reticulum of a cell." [GOC:mah] comment: This term was made obsolete because there is no evidence in the literature of its existence. is_obsolete: true [Term] id: GO:0031615 name: cytosolic proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:mah, GOC:mtg_sensu] is_a: GO:0008541 ! proteasome regulatory particle, lid subcomplex is_a: GO:0044445 ! cytosolic part relationship: part_of GO:0031600 ! cytosolic proteasome regulatory particle [Term] id: GO:0031616 name: spindle pole centrosome namespace: cellular_component def: "A centrosome from which one pole of a mitotic or meiotic spindle is organized." [GOC:mah] is_a: GO:0005813 ! centrosome relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0031617 name: NMS complex namespace: cellular_component def: "A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes." [PMID:16079914] synonym: "KMN kinetochore network" EXACT [] synonym: "KNL-1-Mis12-Ndc80" EXACT [] synonym: "Ndc80-MIND-Spc7 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000776 ! kinetochore [Term] id: GO:0031618 name: nuclear pericentric heterochromatin namespace: cellular_component alt_id: GO:0002137 def: "Nuclear heterochromatin that is located adjacent to the CENP-A rich centromere 'central core' and characterized by the modified histone H3K9me3." [GOC:mah, PMID:20206496, PMID:22729156, PMID:9413993] synonym: "nuclear centric heterochromatin" EXACT [] synonym: "nuclear cluster" NARROW [] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0005721 ! pericentric heterochromatin [Term] id: GO:0031619 name: homologous chromosome orientation involved in meiotic metaphase I plate congression namespace: biological_process def: "The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I." [PMID:15062096] synonym: "homologous chromosome orientation during meiosis" RELATED [GOC:dph, GOC:tb] synonym: "homologous chromosome orientation during meiosis I" RELATED [] is_a: GO:0051455 ! attachment of spindle microtubules to kinetochore involved in homologous chromosome segregation relationship: part_of GO:0043060 ! meiotic metaphase I plate congression [Term] id: GO:0031620 name: regulation of fever generation namespace: biological_process def: "Any process that modulates the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "regulation of pyrexia" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0031650 ! regulation of heat generation relationship: regulates GO:0001660 ! fever generation [Term] id: GO:0031621 name: negative regulation of fever generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of fever generation." [GOC:add, GOC:dph, GOC:tb] synonym: "down regulation of fever" EXACT [] synonym: "down-regulation of fever" EXACT [] synonym: "downregulation of fever" EXACT [] synonym: "inhibition of fever" NARROW [] synonym: "negative regulation of pyrexia" EXACT [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031651 ! negative regulation of heat generation relationship: negatively_regulates GO:0001660 ! fever generation [Term] id: GO:0031622 name: positive regulation of fever generation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fever generation." [GOC:add] synonym: "activation of fever" NARROW [] synonym: "positive regulation of pyrexia" EXACT [] synonym: "stimulation of fever" NARROW [] synonym: "up regulation of fever" EXACT [] synonym: "up-regulation of fever" EXACT [] synonym: "upregulation of fever" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0031620 ! regulation of fever generation is_a: GO:0031652 ! positive regulation of heat generation relationship: positively_regulates GO:0001660 ! fever generation [Term] id: GO:0031623 name: receptor internalization namespace: biological_process def: "A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane." [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] is_a: GO:0006898 ! receptor-mediated endocytosis is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0031624 name: ubiquitin conjugating enzyme binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin conjugating enzyme, any of the E2 proteins." [GOC:vp] is_a: GO:0044390 ! ubiquitin-like protein conjugating enzyme binding [Term] id: GO:0031625 name: ubiquitin protein ligase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ubiquitin protein ligase enzyme, any of the E3 proteins." [GOC:vp] synonym: "ubiquitin ligase binding" EXACT [] is_a: GO:0044389 ! ubiquitin-like protein ligase binding [Term] id: GO:0031626 name: beta-endorphin binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-endorphin, a peptide generated by the cleavage of pro-opiomelanocortin." [GOC:nln, PMID:6267560] is_a: GO:0042165 ! neurotransmitter binding is_a: GO:0042277 ! peptide binding [Term] id: GO:0031627 name: telomeric loop formation namespace: biological_process def: "The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region." [GOC:vw, PMID:10338214] synonym: "T loop biosynthesis" EXACT [] synonym: "T loop formation" EXACT [] synonym: "t-loop biosynthesis" EXACT [] synonym: "t-loop formation" EXACT [] is_a: GO:0000723 ! telomere maintenance [Term] id: GO:0031628 name: opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opioid receptor." [GOC:nln] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031629 name: synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft." [ISBN:0071120009] subset: goslim_synapse synonym: "synaptic vesicle fusion" BROAD [] synonym: "synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0099500 ! vesicle fusion to plasma membrane relationship: part_of GO:0016079 ! synaptic vesicle exocytosis [Term] id: GO:0031630 name: regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] subset: goslim_synapse synonym: "regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0031338 ! regulation of vesicle fusion is_a: GO:2000300 ! regulation of synaptic vesicle exocytosis relationship: regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031631 name: negative regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "down regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "down regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "down-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "down-regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "downregulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "downregulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "inhibition of synaptic vesicle fusion to presynaptic membrane" BROAD [] synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic active zone membrane" EXACT [] synonym: "negative regulation of synaptic vesicle fusion to pre-synaptic membrane" BROAD [] synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" BROAD [] is_a: GO:0031339 ! negative regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane is_a: GO:2000301 ! negative regulation of synaptic vesicle exocytosis relationship: negatively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031632 name: positive regulation of synaptic vesicle fusion to presynaptic active zone membrane namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane." [GOC:mah] synonym: "activation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "negative regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "positive regulation of synaptic vesicle fusion to pre-synaptic membrane" EXACT [] synonym: "stimulation of synaptic vesicle fusion to presynaptic membrane" NARROW [] synonym: "up regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "up regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "up-regulation of synaptic vesicle fusion to presynaptic active zone membrane" EXACT [] synonym: "up-regulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] synonym: "upregulation of synaptic vesicle fusion to presynaptic membrane" EXACT [] is_a: GO:0031340 ! positive regulation of vesicle fusion is_a: GO:0031630 ! regulation of synaptic vesicle fusion to presynaptic active zone membrane is_a: GO:2000302 ! positive regulation of synaptic vesicle exocytosis relationship: positively_regulates GO:0031629 ! synaptic vesicle fusion to presynaptic active zone membrane [Term] id: GO:0031633 name: xanthophore namespace: cellular_component def: "A chromatophore containing yellow pigment." [ISBN:0395825172] comment: Note that this term refers to a subcellular structure, and should not be confused with the specialized cells known as xanthophores, which produce yellow pigment and are found in fish and amphibian skin. Note that several terms in the biological process ontology ('xanthophore differentiation ; GO:0050936' and its children) refer to xanthophores in the sense of pigment-producing cells. is_a: GO:0042716 ! plasma membrane-derived chromatophore [Term] id: GO:0031634 name: replication fork barrier binding namespace: molecular_function def: "Interacting selectively and non-covalently with replication fork barriers, sites that inhibit the progress of replication forks." [GOC:mah] is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0031635 name: adenylate cyclase-inhibiting opioid receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an opioid receptor binding to its physiological ligand, where the pathway proceeds with inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP (cAMP)." [GOC:dph, GOC:mah, GOC:signaling, GOC:tb] synonym: "inhibition of adenylate cyclase activity by opioid receptor signaling pathway" RELATED [GOC:signaling] synonym: "inhibition of adenylate cyclase activity by opioid receptor signalling pathway" RELATED [GOC:mah] synonym: "opioid receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007193 ! adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway is_a: GO:0038003 ! opioid receptor signaling pathway [Term] id: GO:0031637 name: regulation of neuronal synaptic plasticity in response to neurotrophin namespace: biological_process def: "The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah, PMID:8703078] synonym: "neurotrophin-induced neuronal synaptic plasticity" EXACT [] is_a: GO:0048168 ! regulation of neuronal synaptic plasticity [Term] id: GO:0031638 name: zymogen activation namespace: biological_process def: "The proteolytic processing of an inactive enzyme to an active form." [GOC:hjd] subset: goslim_chembl synonym: "zymogen activation by proteolytic cleavage" EXACT [] is_a: GO:0016485 ! protein processing [Term] id: GO:0031639 name: plasminogen activation namespace: biological_process def: "The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide." [PMID:9548733] subset: goslim_chembl synonym: "cleavage of plasminogen to plasmin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0031640 name: killing of cells of other organism namespace: biological_process alt_id: GO:0001908 def: "Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir synonym: "killing of cells of another organism" EXACT [GOC:bf] synonym: "killing of cells of another, non-host, organism" NARROW [] is_a: GO:0001906 ! cell killing is_a: GO:0044364 ! disruption of cells of other organism [Term] id: GO:0031641 name: regulation of myelination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051960 ! regulation of nervous system development relationship: regulates GO:0042552 ! myelination [Term] id: GO:0031642 name: negative regulation of myelination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "down regulation of myelination" EXACT [] synonym: "down-regulation of myelination" EXACT [] synonym: "downregulation of myelination" EXACT [] synonym: "inhibition of myelination" NARROW [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031645 ! negative regulation of neurological system process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051961 ! negative regulation of nervous system development relationship: negatively_regulates GO:0042552 ! myelination [Term] id: GO:0031643 name: positive regulation of myelination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons." [GOC:mah] synonym: "activation of myelination" NARROW [] synonym: "stimulation of myelination" NARROW [] synonym: "up regulation of myelination" EXACT [] synonym: "up-regulation of myelination" EXACT [] synonym: "upregulation of myelination" EXACT [] is_a: GO:0031641 ! regulation of myelination is_a: GO:0031646 ! positive regulation of neurological system process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051962 ! positive regulation of nervous system development relationship: positively_regulates GO:0042552 ! myelination [Term] id: GO:0031644 name: regulation of neurological system process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of neurological system." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "regulation of neurophysiological process" EXACT [] is_a: GO:0044057 ! regulation of system process relationship: regulates GO:0050877 ! nervous system process [Term] id: GO:0031645 name: negative regulation of neurological system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of neurological process" EXACT [] synonym: "down-regulation of neurological process" EXACT [] synonym: "downregulation of neurological process" EXACT [] synonym: "inhibition of neurological process" NARROW [] synonym: "negative regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of neurophysiological process" EXACT [] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031646 name: positive regulation of neurological system process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a neurophysiological process." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of neurological process" NARROW [] synonym: "positive regulation of neurological process" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of neurophysiological process" EXACT [] synonym: "stimulation of neurological process" NARROW [] synonym: "up regulation of neurological process" EXACT [] synonym: "up-regulation of neurological process" EXACT [] synonym: "upregulation of neurological process" EXACT [] is_a: GO:0031644 ! regulation of neurological system process is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0050877 ! nervous system process [Term] id: GO:0031647 name: regulation of protein stability namespace: biological_process def: "Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0031648 name: protein destabilization namespace: biological_process def: "Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation." [GOC:mah] synonym: "negative regulation of protein stability" EXACT [] synonym: "protein destabilisation" EXACT [GOC:ah] is_a: GO:0031647 ! regulation of protein stability [Term] id: GO:0031649 name: heat generation namespace: biological_process def: "Any homeostatic process in which an organism produces heat, thereby raising its internal temperature." [GOC:mah] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031650 name: regulation of heat generation namespace: biological_process def: "Any process that modulates the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0031649 ! heat generation [Term] id: GO:0031651 name: negative regulation of heat generation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat generation" EXACT [] synonym: "down-regulation of heat generation" EXACT [] synonym: "downregulation of heat generation" EXACT [] synonym: "inhibition of heat generation" NARROW [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0031649 ! heat generation [Term] id: GO:0031652 name: positive regulation of heat generation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat generation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat generation" NARROW [] synonym: "stimulation of heat generation" NARROW [] synonym: "up regulation of heat generation" EXACT [] synonym: "up-regulation of heat generation" EXACT [] synonym: "upregulation of heat generation" EXACT [] is_a: GO:0031650 ! regulation of heat generation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0031649 ! heat generation [Term] id: GO:0031653 name: heat dissipation namespace: biological_process def: "Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature." [GOC:mah] is_a: GO:0001659 ! temperature homeostasis [Term] id: GO:0031654 name: regulation of heat dissipation namespace: biological_process def: "Any process that modulates the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] is_a: GO:0051239 ! regulation of multicellular organismal process is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0031653 ! heat dissipation [Term] id: GO:0031655 name: negative regulation of heat dissipation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of heat dissipation" EXACT [] synonym: "down-regulation of heat dissipation" EXACT [] synonym: "downregulation of heat dissipation" EXACT [] synonym: "inhibition of heat dissipation" NARROW [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031656 name: positive regulation of heat dissipation namespace: biological_process def: "Any process that activates or increases the rate or extent of heat dissipation." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of heat dissipation" NARROW [] synonym: "stimulation of heat dissipation" NARROW [] synonym: "up regulation of heat dissipation" EXACT [] synonym: "up-regulation of heat dissipation" EXACT [] synonym: "upregulation of heat dissipation" EXACT [] is_a: GO:0031654 ! regulation of heat dissipation is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0031653 ! heat dissipation [Term] id: GO:0031657 name: obsolete regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that controls the frequency, rate or extent of G1 cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:mtg_cell_cycle, GOC:pr] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031658 name: obsolete negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031659 name: obsolete positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition of mitotic cell cycle namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G1/S transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] comment: The term has been obsoleted because it represents a GO-CAM model. synonym: "G1/S-specific activation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific positive regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "G1/S-specific stimulation of cyclin-dependent protein kinase activity" NARROW [] synonym: "G1/S-specific up regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific up-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G1/S-specific upregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "positive regulation of cyclin-dependent protein kinase activity during G1/S" RELATED [GOC:dph, GOC:tb] synonym: "positive regulation of cyclin-dependent protein kinase activity involved in G1/S" BROAD [] is_obsolete: true [Term] id: GO:0031660 name: regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] synonym: "G2/M-specific regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] synonym: "regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] is_a: GO:0000079 ! regulation of cyclin-dependent protein serine/threonine kinase activity is_a: GO:0010389 ! regulation of G2/M transition of mitotic cell cycle [Term] id: GO:0031661 name: negative regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity contributing to the G2/M transition of the cell cycle." [GOC:dph, GOC:mah, GOC:pr, GOC:tb] synonym: "G2/M-specific down regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific down-regulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific downregulation of cyclin-dependent protein kinase activity" EXACT [] synonym: "G2/M-specific inhibition of cyclin-dependent protein kinase activity" NARROW [] synonym: "G2/M-specific negative regulation of cyclin-dependent protein kinase activity" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity during G2/M" RELATED [GOC:dph, GOC:tb] synonym: "negative regulation of cyclin-dependent protein kinase activity involved in G2/M" BROAD [] is_a: GO:0031660 ! regulation of cyclin-dependent protein serine/threonine kinase activity involved in G2/M transition of mitotic cell cycle is_a: GO:0045736 ! negative regulation of cyclin-dependent protein serine/threonine kinase activity [Term] id: GO:0031663 name: lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [GOC:mah, GOC:signaling, PMID:15379975] synonym: "lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "LPS-mediated signaling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor signaling pathway relationship: part_of GO:0071222 ! cellular response to lipopolysaccharide [Term] id: GO:0031664 name: regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0043900 ! regulation of multi-organism process relationship: regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031665 name: negative regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "down regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "down-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "downregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "inhibition of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "negative regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "negative regulation of LPS-mediated signaling pathway" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0009968 ! negative regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0043901 ! negative regulation of multi-organism process relationship: negatively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031666 name: positive regulation of lipopolysaccharide-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide." [GOC:mah] synonym: "activation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "positive regulation of lipopolysaccharide-mediated signalling pathway" EXACT [] synonym: "positive regulation of LPS-mediated signaling pathway" EXACT [] synonym: "stimulation of lipopolysaccharide-mediated signaling pathway" NARROW [] synonym: "up regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "up-regulation of lipopolysaccharide-mediated signaling pathway" EXACT [] synonym: "upregulation of lipopolysaccharide-mediated signaling pathway" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0009967 ! positive regulation of signal transduction is_a: GO:0031664 ! regulation of lipopolysaccharide-mediated signaling pathway is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0043902 ! positive regulation of multi-organism process relationship: positively_regulates GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0031667 name: response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0009991 ! response to extracellular stimulus [Term] id: GO:0031668 name: cellular response to extracellular stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:mah] is_a: GO:0007154 ! cell communication is_a: GO:0009991 ! response to extracellular stimulus is_a: GO:0051716 ! cellular response to stimulus is_a: GO:0071496 ! cellular response to external stimulus [Term] id: GO:0031669 name: cellular response to nutrient levels namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients." [GOC:mah] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0031670 name: cellular response to nutrient namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:mah] is_a: GO:0007584 ! response to nutrient is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0070887 ! cellular response to chemical stimulus [Term] id: GO:0031671 name: primary cell septum biogenesis namespace: biological_process def: "A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division." [GOC:jl] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:1902410 ! mitotic cytokinetic process relationship: part_of GO:0140278 ! mitotic division septum assembly [Term] id: GO:0031672 name: A band namespace: cellular_component def: "The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line." [ISBN:0321204131] synonym: "A disc" EXACT [] synonym: "anisotropic disc" EXACT [] synonym: "Q disc" EXACT [] synonym: "transverse disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031673 name: H zone namespace: cellular_component def: "A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments." [GOC:mtg_muscle, ISBN:0321204131] synonym: "H band" EXACT [] synonym: "H disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0031672 ! A band [Term] id: GO:0031674 name: I band namespace: cellular_component def: "A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end." [ISBN:0321204131] synonym: "I disc" EXACT [] synonym: "isotropic disc" EXACT [] synonym: "J disc" EXACT [] xref: Wikipedia:Sarcomere#bands is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0031676 name: plasma membrane-derived thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid membrane" EXACT [] is_a: GO:0042651 ! thylakoid membrane is_a: GO:0042717 ! plasma membrane-derived chromatophore membrane is_a: GO:0044422 ! organelle part is_a: GO:0098590 ! plasma membrane region relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0031679 name: NADH dehydrogenase (plastoquinone) activity namespace: molecular_function alt_id: GO:0030024 def: "Catalysis of the reaction: NADH + H+ + plastoquinone = NAD+ + plastoquinol." [EC:1.6.99.6, GOC:mah] synonym: "NADH:plastoquinone reductase activity" EXACT [] is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0031680 name: G-protein beta/gamma-subunit complex namespace: cellular_component def: "The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange." [GOC:mah] comment: See also the cellular component term 'heterotrimeric G-protein complex ; GO:0005834'. synonym: "G-beta/G-gamma complex" EXACT [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0031681 name: G-protein beta-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein beta subunit." [GOC:mah] synonym: "G-beta protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031682 name: G-protein gamma-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein gamma subunit." [GOC:mah] synonym: "G-gamma protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0031683 name: G-protein beta/gamma-subunit complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a complex of G-protein beta/gamma subunits." [GOC:nln, GOC:vw] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0031684 name: obsolete heterotrimeric G-protein complex cycle namespace: biological_process def: "OBSOLETE. The series of molecular events that generate a signal through the activation of G-protein subunits and recycling of these subunits." [GOC:nln] comment: The reason for obsoleting is that it is an arbitrary grouping term that groups the molecular functions required for the G-protein complex cycle, and this is not a bona fide biological process. is_obsolete: true [Term] id: GO:0031685 name: adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenosine receptor." [GOC:mah, GOC:nln] synonym: "adenosine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031686 name: A1 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A1 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A1 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031687 name: A2A adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2A adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2A adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031688 name: A2B adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A2B adenosine receptor." [GOC:mah, GOC:nln] synonym: "A2B adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031689 name: A3 adenosine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an A3 adenosine receptor." [GOC:mah, GOC:nln] synonym: "A3 adenosine receptor ligand" NARROW [] is_a: GO:0031685 ! adenosine receptor binding [Term] id: GO:0031690 name: adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenergic receptor." [GOC:mah, GOC:nln] synonym: "adrenergic receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031691 name: alpha-1A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031692 name: alpha-1B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031693 name: alpha-1D adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-1D adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-1D adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031694 name: alpha-2A adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2A adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2A adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031695 name: alpha-2B adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2B adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2B adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031696 name: alpha-2C adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an alpha-2C adrenergic receptor." [GOC:mah, GOC:nln] synonym: "alpha-2C adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031697 name: beta-1 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-1 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-1 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031698 name: beta-2 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-2 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-2 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031699 name: beta-3 adrenergic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a beta-3 adrenergic receptor." [GOC:mah, GOC:nln] synonym: "beta-3 adrenergic receptor ligand" NARROW [] is_a: GO:0031690 ! adrenergic receptor binding [Term] id: GO:0031700 name: adrenomedullin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adrenomedullin receptor." [GOC:mah, GOC:nln] synonym: "adrenomedullin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031701 name: angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an angiotensin receptor." [GOC:mah, GOC:nln] synonym: "angiotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031702 name: type 1 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT1 receptor binding" EXACT [] synonym: "type 1 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031703 name: type 2 angiotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 angiotensin receptor." [GOC:mah, GOC:nln] synonym: "AT2 receptor binding" EXACT [] synonym: "type 2 angiotensin receptor ligand" NARROW [] is_a: GO:0031701 ! angiotensin receptor binding [Term] id: GO:0031704 name: apelin receptor binding namespace: molecular_function alt_id: GO:0042569 def: "Interacting selectively and non-covalently with an apelin receptor." [GOC:mah, GOC:nln, GOC:vp, PMID:12787050] synonym: "apelin receptor ligand" NARROW [] synonym: "APJ receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031705 name: bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bombesin receptor." [GOC:mah, GOC:nln] synonym: "bombesin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031706 name: subtype 3 bombesin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a subtype 3 bombesin receptor." [GOC:mah, GOC:nln] synonym: "subtype 3 bombesin receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031707 name: endothelin A receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin A receptor." [GOC:mah, GOC:nln] synonym: "endothelin A receptor ligand" NARROW [] synonym: "endothelin-1 receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031708 name: endothelin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelin B receptor." [GOC:mah, GOC:nln] synonym: "endothelin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031709 name: gastrin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastrin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "gastrin-releasing peptide receptor ligand" NARROW [] synonym: "GRP receptor binding" EXACT [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031710 name: neuromedin B receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin B receptor." [GOC:mah, GOC:nln] synonym: "neuromedin B receptor ligand" NARROW [] is_a: GO:0031705 ! bombesin receptor binding [Term] id: GO:0031711 name: bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a bradykinin receptor." [GOC:mah, GOC:nln] synonym: "bradykinin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031712 name: B1 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B1 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B1 bradykinin receptor ligand" NARROW [] is_a: GO:0031711 ! bradykinin receptor binding [Term] id: GO:0031713 name: B2 bradykinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a B2 bradykinin receptor." [GOC:mah, GOC:nln] synonym: "B2 bradykinin receptor ligand" NARROW [] is_a: GO:0031711 ! bradykinin receptor binding [Term] id: GO:0031714 name: C5a anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5a anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5a anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031715 name: C5L2 anaphylatoxin chemotactic receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a C5L2 anaphylatoxin chemotactic receptor." [GOC:mah, GOC:nln] synonym: "C5L2 anaphylatoxin chemotactic receptor ligand" NARROW [] is_a: GO:0031714 ! C5a anaphylatoxin chemotactic receptor binding [Term] id: GO:0031716 name: calcitonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a calcitonin receptor." [GOC:mah, GOC:nln] synonym: "calcitonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031717 name: cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "cannabinoid receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031718 name: type 1 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 1 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031719 name: type 2 cannabinoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cannabinoid receptor." [GOC:mah, GOC:nln] synonym: "type 2 cannabinoid receptor ligand" NARROW [] is_a: GO:0031717 ! cannabinoid receptor binding [Term] id: GO:0031720 name: haptoglobin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex." [GOC:mah, ISBN:0198506732] is_a: GO:0005515 ! protein binding [Term] id: GO:0031721 name: hemoglobin alpha binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin alpha chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031722 name: hemoglobin beta binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hemoglobin beta chain." [GOC:mah] is_a: GO:0030492 ! hemoglobin binding [Term] id: GO:0031723 name: CXCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR4 chemokine receptor ligand" NARROW [] synonym: "stromal cell-derived factor 1 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031724 name: CXCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CXCR5 chemokine receptor ligand" NARROW [] synonym: "type 1 Burkitt's lymphoma receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031725 name: CXCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CXCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "bonzo receptor binding" EXACT [] synonym: "CXCR6 chemokine receptor ligand" NARROW [] synonym: "STRL33 receptor binding" EXACT [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0031726 name: CCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR1 chemokine receptor ligand" NARROW [] synonym: "macrophage inflammatory protein-1 alpha receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031727 name: CCR2 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR2 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR2 chemokine receptor ligand" NARROW [] synonym: "monocyte chemoattractant protein 1 receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031728 name: CCR3 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR3 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR3 chemokine receptor ligand" NARROW [] synonym: "eosinophil eotaxin receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031729 name: CCR4 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR4 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR4 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031730 name: CCR5 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR5 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR5 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031731 name: CCR6 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR6 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR6 chemokine receptor ligand" NARROW [] synonym: "LARC receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031732 name: CCR7 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR7 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR7 chemokine receptor ligand" NARROW [] synonym: "MIP-3 beta receptor binding" EXACT [] synonym: "type 1 EBV-induced G-protein coupled receptor binding" EXACT [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031733 name: CCR8 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR8 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR8 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031734 name: CCR9 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR9 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR9 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031735 name: CCR10 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR10 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR10 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031736 name: CCR11 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CCR11 chemokine receptor." [GOC:mah, GOC:nln] synonym: "CCR11 chemokine receptor ligand" NARROW [] is_a: GO:0048020 ! CCR chemokine receptor binding [Term] id: GO:0031737 name: CX3C chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CX3C chemokine receptor." [GOC:mah, GOC:nln] synonym: "CX3C chemokine receptor ligand" NARROW [] synonym: "fractalkine receptor binding" EXACT [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0031738 name: XCR1 chemokine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a XCR1 chemokine receptor." [GOC:mah, GOC:nln] synonym: "lymphotactin receptor binding" EXACT [] synonym: "XCR1 chemokine receptor ligand" NARROW [] is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0031739 name: cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "cholecystokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031740 name: type A cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type A cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type A cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031741 name: type B gastrin/cholecystokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type B gastrin/cholecystokinin receptor." [GOC:mah, GOC:nln] synonym: "type B gastrin/cholecystokinin receptor ligand" NARROW [] is_a: GO:0031739 ! cholecystokinin receptor binding [Term] id: GO:0031745 name: cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031746 name: type 1 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 1 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031747 name: type 2 cysteinyl leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 cysteinyl leukotriene receptor." [GOC:mah, GOC:nln] synonym: "type 2 cysteinyl leukotriene receptor ligand" NARROW [] is_a: GO:0031745 ! cysteinyl leukotriene receptor binding [Term] id: GO:0031748 name: D1 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D1 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1 dopamine receptor ligand" NARROW [] synonym: "D1A dopamine receptor binding" EXACT [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031749 name: D2 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D2 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D2 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031750 name: D3 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D3 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D3 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031751 name: D4 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D4 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D4 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031752 name: D5 dopamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a D5 dopamine receptor." [GOC:mah, GOC:nln] synonym: "D1B dopamine receptor binding" EXACT [] synonym: "D5 dopamine receptor ligand" NARROW [] is_a: GO:0050780 ! dopamine receptor binding [Term] id: GO:0031753 name: endothelial differentiation G protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an endothelial differentiation G protein-coupled receptor." [GOC:mah, GOC:nln] synonym: "endothelial differentiation G-protein coupled receptor binding" EXACT [] synonym: "endothelial differentiation G-protein coupled receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031754 name: Edg-1 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-1 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-1 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031755 name: Edg-2 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-2 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-2 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA1 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031756 name: Edg-3 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-3 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-3 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031757 name: Edg-4 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-4 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-4 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA2 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031758 name: Edg-5 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-5 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-5 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031759 name: Edg-6 sphingosine 1-phosphate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-6 sphingosine 1-phosphate receptor." [GOC:mah, GOC:nln] synonym: "Edg-6 sphingosine 1-phosphate receptor ligand" NARROW [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031760 name: Edg-7 lysophosphatidic acid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an Edg-7 lysophosphatidic acid receptor." [GOC:mah, GOC:nln] synonym: "Edg-7 lysophosphatidic acid receptor ligand" NARROW [] synonym: "LPA3 receptor binding" EXACT [] is_a: GO:0031753 ! endothelial differentiation G protein-coupled receptor binding [Term] id: GO:0031761 name: fMet-Leu-Phe receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fMet-Leu-Phe receptor." [GOC:mah, GOC:nln] synonym: "fMet-Leu-Phe receptor ligand" NARROW [] synonym: "N-formyl peptide receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031762 name: follicle-stimulating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a follicle-stimulating hormone receptor." [GOC:mah, GOC:nln] synonym: "follicle stimulating hormone receptor binding" EXACT [] synonym: "follicle stimulating hormone receptor ligand" NARROW [] synonym: "FSH receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031763 name: galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a galanin receptor." [GOC:mah, GOC:nln] synonym: "galanin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031764 name: type 1 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 1 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031765 name: type 2 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 2 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031766 name: type 3 galanin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 galanin receptor." [GOC:mah, GOC:nln] synonym: "type 3 galanin receptor ligand" NARROW [] is_a: GO:0031763 ! galanin receptor binding [Term] id: GO:0031767 name: gastric inhibitory polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a gastric inhibitory polypeptide receptor." [GOC:mah, GOC:nln] synonym: "gastric inhibitory polypeptide receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031768 name: ghrelin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ghrelin receptor." [GOC:mah, GOC:nln] synonym: "ghrelin receptor ligand" NARROW [] synonym: "type 1 growth hormone secretagogue GH-releasing peptide receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031769 name: glucagon receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glucagon receptor." [GOC:mah, GOC:nln] synonym: "glucagon receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031770 name: growth hormone-releasing hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a growth hormone-releasing hormone receptor." [GOC:mah, GOC:nln] synonym: "growth hormone-releasing hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031771 name: type 1 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 1 hypocretin receptor ligand" NARROW [] synonym: "type 1 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031772 name: type 2 hypocretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 hypocretin receptor." [GOC:mah, GOC:nln] synonym: "type 2 hypocretin receptor ligand" NARROW [] synonym: "type 2 orexin receptor binding" EXACT [] is_a: GO:0042324 ! hypocretin receptor binding [Term] id: GO:0031773 name: kisspeptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kisspeptin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled receptor 54 binding" EXACT [] synonym: "hOT7T175 receptor binding" EXACT [] synonym: "hypogonadotropin-1 receptor binding" EXACT [] synonym: "KiSS-1 receptor binding" EXACT [] synonym: "kisspeptin receptor ligand" NARROW [] synonym: "metastin receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031774 name: leukotriene receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a leukotriene receptor." [GOC:mah, GOC:nln] synonym: "leukotriene receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031775 name: lutropin-choriogonadotropic hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lutropin-choriogonadotropic hormone receptor." [GOC:mah, GOC:nln] synonym: "lutropin-choriogonadotropic hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031776 name: melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031777 name: type 1 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031778 name: type 2 melanin-concentrating hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 melanin-concentrating hormone receptor." [GOC:mah, GOC:nln] synonym: "type 2 melanin-concentrating hormone receptor ligand" NARROW [] is_a: GO:0031776 ! melanin-concentrating hormone receptor binding [Term] id: GO:0031779 name: melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melanocortin receptor." [GOC:mah, GOC:nln] synonym: "melanocortin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031780 name: corticotropin hormone receptor binding namespace: molecular_function alt_id: GO:0071856 def: "Interacting selectively and non-covalently with a corticotropin hormone receptor." [GOC:dph, GOC:mah, GOC:nln] synonym: "ACTH receptor binding" EXACT [] synonym: "adrenocorticotropic hormone receptor ligand" NARROW [] synonym: "adrenocorticotropin hormone receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "adrenocorticotropin receptor binding" EXACT [GOC:dph] synonym: "corticotropin receptor binding" EXACT [GOC:bf] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031781 name: type 3 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 3 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031782 name: type 4 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 4 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031783 name: type 5 melanocortin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 melanocortin receptor." [GOC:mah, GOC:nln] synonym: "type 5 melanocortin receptor ligand" NARROW [] is_a: GO:0031779 ! melanocortin receptor binding [Term] id: GO:0031784 name: melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a melatonin receptor." [GOC:mah, GOC:nln] synonym: "melatonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031785 name: type 1A melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1A melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1A melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031786 name: type 1B melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B melatonin receptor." [GOC:mah, GOC:nln] synonym: "type 1B melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031787 name: H9 melatonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H9 melatonin receptor." [GOC:mah, GOC:nln] synonym: "H9 melatonin receptor ligand" NARROW [] is_a: GO:0031784 ! melatonin receptor binding [Term] id: GO:0031788 name: motilin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a motilin receptor." [GOC:mah, GOC:nln] synonym: "motilin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031789 name: G protein-coupled acetylcholine receptor binding namespace: molecular_function alt_id: GO:0031790 alt_id: GO:0031791 alt_id: GO:0031792 alt_id: GO:0031793 alt_id: GO:0031794 def: "Interacting selectively and non-covalently with a G protein-coupled acetylcholine receptor." [GOC:bf, GOC:mah, GOC:nln] synonym: "G-protein coupled acetylcholine receptor binding" EXACT [] synonym: "M1 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M1 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M2 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M2 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M3 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M3 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M4 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M4 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "M5 muscarinic acetylcholine receptor binding" NARROW [] synonym: "M5 muscarinic acetylcholine receptor ligand" NARROW [] synonym: "muscarinic acetylcholine receptor binding" EXACT [GOC:bf] synonym: "muscarinic acetylcholine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031795 name: G protein-coupled GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) GABA receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled GABA receptor binding" EXACT [] synonym: "GABAB receptor binding" EXACT [] synonym: "metabotropic GABA receptor binding" EXACT [GOC:bf] synonym: "metabotropic GABA receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding is_a: GO:0050811 ! GABA receptor binding [Term] id: GO:0031796 name: type 1 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! G protein-coupled GABA receptor binding [Term] id: GO:0031797 name: type 2 metabotropic GABA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic GABA receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic GABA receptor ligand" NARROW [] is_a: GO:0031795 ! G protein-coupled GABA receptor binding [Term] id: GO:0031798 name: type 1 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 1 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031799 name: type 2 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 2 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031800 name: type 3 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 3 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031801 name: type 4 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 4 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031802 name: type 5 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 5 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031803 name: type 6 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 6 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031804 name: type 7 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 7 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031805 name: type 8 metabotropic glutamate receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 8 metabotropic glutamate receptor." [GOC:mah, GOC:nln] synonym: "type 8 metabotropic glutamate receptor ligand" NARROW [] is_a: GO:0035256 ! G protein-coupled glutamate receptor binding [Term] id: GO:0031806 name: G protein-coupled histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) histamine receptor." [GOC:mah, GOC:nln, PMID:12679144] synonym: "G-protein coupled histamine receptor binding" EXACT [] synonym: "metabotropic histamine receptor binding" EXACT [GOC:bf] synonym: "metabotropic histamine receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031807 name: H1 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H1 histamine receptor." [GOC:mah, GOC:nln] synonym: "H1 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031808 name: H2 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H2 histamine receptor." [GOC:mah, GOC:nln] synonym: "H2 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031809 name: H3 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H3 histamine receptor." [GOC:mah, GOC:nln] synonym: "H3 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031810 name: H4 histamine receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a H4 histamine receptor." [GOC:mah, GOC:nln] synonym: "H4 histamine receptor ligand" NARROW [] is_a: GO:0031806 ! G protein-coupled histamine receptor binding [Term] id: GO:0031811 name: G protein-coupled nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G protein-coupled (metabotropic) nucleotide receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled nucleotide receptor binding" EXACT [] synonym: "metabotropic nucleotide receptor binding" EXACT [GOC:bf] synonym: "metabotropic nucleotide receptor ligand" NARROW [] synonym: "P2Y receptor binding" EXACT [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031812 name: P2Y1 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y1 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y1 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031813 name: P2Y2 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y2 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y2 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031814 name: P2Y4 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y4 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y4 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031815 name: P2Y5 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y5 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y5 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031816 name: P2Y6 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y6 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y6 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031817 name: P2Y8 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y8 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y8 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031818 name: P2Y9 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y9 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y9 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031819 name: P2Y10 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y10 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y10 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031820 name: P2Y11 nucleotide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a P2Y11 nucleotide receptor." [GOC:mah, GOC:nln] synonym: "P2Y11 nucleotide receptor ligand" NARROW [] is_a: GO:0031811 ! G protein-coupled nucleotide receptor binding [Term] id: GO:0031821 name: G protein-coupled serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a metabotropic serotonin receptor." [GOC:mah, GOC:nln] synonym: "G-protein coupled serotonin receptor binding" EXACT [] synonym: "metabotropic 5-hydroxytryptamine receptor binding" EXACT [] synonym: "metabotropic serotonin receptor binding" EXACT [GOC:bf] synonym: "metabotropic serotonin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031822 name: type 1B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1B receptor binding" EXACT [] synonym: "type 1B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031823 name: type 1D serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1D serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1D receptor binding" EXACT [] synonym: "type 1D serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031824 name: type 1E serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1E serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1E receptor binding" EXACT [] synonym: "type 1E serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031825 name: type 1F serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1F serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 1F receptor binding" EXACT [] synonym: "type 1F serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031826 name: type 2A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2A receptor binding" EXACT [] synonym: "type 2A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031827 name: type 2B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2B receptor binding" EXACT [] synonym: "type 2B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031828 name: type 2C serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2C serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 2C receptor binding" EXACT [] synonym: "type 2C serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031829 name: type 4 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 4 receptor binding" EXACT [] synonym: "type 4 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031830 name: type 5A serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5A serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5A receptor binding" EXACT [] synonym: "type 5A serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031831 name: type 5B serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5B serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 5B receptor binding" EXACT [] synonym: "type 5B serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031832 name: type 6 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 6 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 6 receptor binding" EXACT [] synonym: "type 6 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031833 name: type 7 serotonin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 7 serotonin receptor." [GOC:mah, GOC:nln] synonym: "5-hydroxytryptamine 7 receptor binding" EXACT [] synonym: "type 7 serotonin receptor ligand" NARROW [] is_a: GO:0031821 ! G protein-coupled serotonin receptor binding [Term] id: GO:0031834 name: neurokinin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurokinin receptor." [GOC:mah, GOC:nln] synonym: "neurokinin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031835 name: substance P receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance P receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-1 receptor binding" EXACT [] synonym: "substance P receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031836 name: neuromedin K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuromedin K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-B receptor binding" EXACT [] synonym: "neuromedin K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031837 name: substance K receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a substance K receptor." [GOC:mah, GOC:nln] synonym: "neurokinin-A receptor binding" EXACT [] synonym: "substance K receptor ligand" NARROW [] is_a: GO:0031834 ! neurokinin receptor binding [Term] id: GO:0031838 name: haptoglobin-hemoglobin complex namespace: cellular_component def: "A protein complex formed by the stable binding of a haptoglobin to hemoglobin." [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0031839 name: type 1 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031840 name: type 2 neuromedin U receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuromedin U receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuromedin U receptor ligand" NARROW [] is_a: GO:0042922 ! neuromedin U receptor binding [Term] id: GO:0031841 name: neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "neuropeptide Y receptor ligand" NARROW [] synonym: "NPY receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031842 name: type 1 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 1 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031843 name: type 2 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 2 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031844 name: type 4 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "pancreatic polypeptide receptor binding" EXACT [] synonym: "type 4 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031845 name: type 5 neuropeptide Y receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 neuropeptide Y receptor." [GOC:mah, GOC:nln] synonym: "type 5 neuropeptide Y receptor ligand" NARROW [] is_a: GO:0031841 ! neuropeptide Y receptor binding [Term] id: GO:0031846 name: neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotensin receptor." [GOC:mah, GOC:nln] synonym: "neurotensin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031847 name: type 1 neurotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 neurotensin receptor." [GOC:mah, GOC:nln] synonym: "type 1 neurotensin receptor ligand" NARROW [] is_a: GO:0031846 ! neurotensin receptor binding [Term] id: GO:0031848 name: protection from non-homologous end joining at telomere namespace: biological_process def: "A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse." [GOC:mah] synonym: "protection from NHEJ-mediated telomere fusion" EXACT [] is_a: GO:0043247 ! telomere maintenance in response to DNA damage relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031849 name: olfactory receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an olfactory receptor." [GOC:mah, GOC:nln] synonym: "olfactory receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031850 name: delta-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a delta-type opioid receptor." [GOC:mah, GOC:nln] synonym: "delta-type opioid receptor ligand" NARROW [] synonym: "enkephalin receptor binding" RELATED [GOC:sl] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031851 name: kappa-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a kappa-type opioid receptor." [GOC:mah, GOC:nln] synonym: "dynorphin receptor binding" RELATED [] synonym: "kappa-type opioid receptor ligand" NARROW [GOC:sl] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031852 name: mu-type opioid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mu-type opioid receptor." [GOC:mah, GOC:nln, GOC:sl] synonym: "morphine receptor binding" RELATED [GOC:sl] synonym: "mu-type opioid receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031853 name: nociceptin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nociceptin receptor." [GOC:mah, GOC:nln] synonym: "nociceptin receptor ligand" NARROW [] is_a: GO:0031628 ! opioid receptor binding [Term] id: GO:0031854 name: orexigenic neuropeptide QRFP receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an orexigenic neuropeptide QRFP receptor." [GOC:mah, GOC:nln] synonym: "orexigenic neuropeptide QRFP receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031855 name: oxytocin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an oxytocin receptor." [GOC:mah, GOC:nln] synonym: "oxytocin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031856 name: parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "parathyroid hormone receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031857 name: type 1 parathyroid hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 parathyroid hormone receptor." [GOC:mah, GOC:nln] synonym: "type 1 parathyroid hormone receptor ligand" NARROW [] is_a: GO:0031856 ! parathyroid hormone receptor binding [Term] id: GO:0031858 name: pituitary adenylate cyclase-activating polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pituitary adenylate cyclase-activating polypeptide receptor." [GOC:mah, GOC:nln] synonym: "PACAP receptor binding" EXACT [] synonym: "pituitary adenylate cyclase activating peptide receptor binding" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031859 name: platelet activating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a platelet activating factor receptor." [GOC:mah, GOC:nln] synonym: "platelet activating factor receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031860 name: telomeric 3' overhang formation namespace: biological_process def: "The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans." [PMID:16096639] synonym: "telomere 3'-end processing" EXACT [GOC:mah, GOC:vw] synonym: "telomere end processing" RELATED [GOC:mah, GOC:vw] is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0016233 ! telomere capping [Term] id: GO:0031861 name: prolactin-releasing peptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prolactin-releasing peptide receptor." [GOC:mah, GOC:nln] synonym: "prolactin-releasing peptide receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031862 name: prostanoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostanoid receptor." [GOC:mah, GOC:nln] synonym: "prostanoid receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031863 name: prostaglandin D2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin D2 receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin D2 receptor ligand" NARROW [] synonym: "prostanoid DP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031864 name: EP1 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP1 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP1 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP1 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031865 name: EP2 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP2 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP2 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP2 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031866 name: EP3 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP3 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP3 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP3 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031867 name: EP4 subtype prostaglandin E2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an EP4 subtype prostaglandin E2 receptor." [GOC:mah, GOC:nln] synonym: "EP4 subtype prostaglandin E2 receptor ligand" NARROW [] synonym: "prostanoid EP4 receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031868 name: prostaglandin F2-alpha receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostaglandin F2-alpha receptor." [GOC:mah, GOC:nln] synonym: "prostaglandin F2-alpha receptor ligand" NARROW [] synonym: "prostanoid FP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031869 name: prostacyclin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a prostacyclin receptor." [GOC:mah, GOC:nln] synonym: "prostacyclin receptor ligand" NARROW [] synonym: "prostanoid IP receptor binding" EXACT [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031870 name: thromboxane A2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a thromboxane A2 receptor." [GOC:mah, GOC:nln] synonym: "prostanoid TP receptor binding" EXACT [] synonym: "thromboxane A2 receptor ligand" NARROW [] is_a: GO:0031862 ! prostanoid receptor binding [Term] id: GO:0031871 name: proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "proteinase activated receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031872 name: type 1 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "thrombin receptor binding" EXACT [] synonym: "type 1 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031873 name: type 2 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 2 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031874 name: type 3 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 3 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031875 name: type 4 proteinase activated receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 proteinase activated receptor." [GOC:mah, GOC:nln] synonym: "type 4 proteinase activated receptor ligand" NARROW [] is_a: GO:0031871 ! proteinase activated receptor binding [Term] id: GO:0031876 name: secretin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a secretin receptor." [GOC:mah, GOC:nln] synonym: "secretin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031877 name: somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a somatostatin receptor." [GOC:mah, GOC:nln] synonym: "somatostatin receptor ligand" NARROW [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031878 name: type 1 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 1 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031879 name: type 2 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 2 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031880 name: type 3 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 3 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 3 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031881 name: type 4 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 4 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 4 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031882 name: type 5 somatostatin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 5 somatostatin receptor." [GOC:mah, GOC:nln] synonym: "type 5 somatostatin receptor ligand" NARROW [] is_a: GO:0031877 ! somatostatin receptor binding [Term] id: GO:0031883 name: taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a taste receptor." [GOC:mah, GOC:nln] synonym: "taste receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031884 name: type 1 member 1 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 1 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 1 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031885 name: type 1 member 2 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 2 taste receptor." [GOC:mah, GOC:nln] synonym: "type 1 member 2 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031886 name: type 1 member 3 taste receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 member 3 taste receptor." [GOC:mah, GOC:nln] synonym: "sweet taste receptor binding" EXACT [] synonym: "type 1 member 3 taste receptor ligand" NARROW [] is_a: GO:0031883 ! taste receptor binding [Term] id: GO:0031887 name: lipid droplet transport along microtubule namespace: biological_process def: "The directed movement of a lipid droplet along a microtubule, mediated by motor proteins." [PMID:9491895] synonym: "adiposome transport along microtubule" EXACT [] synonym: "lipid body transport along microtubule" EXACT [] synonym: "lipid particle transport along microtubule" EXACT [] is_a: GO:0072384 ! organelle transport along microtubule [Term] id: GO:0031889 name: urotensin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a urotensin receptor." [GOC:mah, GOC:nln] synonym: "urotensin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031890 name: vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "VIP receptor binding" EXACT [] is_a: GO:0071855 ! neuropeptide receptor binding [Term] id: GO:0031891 name: type 1 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 1 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 2 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031892 name: type 2 vasoactive intestinal polypeptide receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 vasoactive intestinal polypeptide receptor." [GOC:mah, GOC:nln] synonym: "type 2 vasoactive intestinal polypeptide receptor ligand" NARROW [] synonym: "type 3 PACAP receptor binding" EXACT [] is_a: GO:0031890 ! vasoactive intestinal polypeptide receptor binding [Term] id: GO:0031893 name: vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vasopressin receptor." [GOC:mah, GOC:nln] synonym: "vasopressin receptor ligand" NARROW [] is_a: GO:0001664 ! G protein-coupled receptor binding [Term] id: GO:0031894 name: V1A vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1A vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1A vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031895 name: V1B vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V1B vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V1B vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031896 name: V2 vasopressin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a V2 vasopressin receptor." [GOC:mah, GOC:nln] synonym: "V2 vasopressin receptor ligand" NARROW [] is_a: GO:0031893 ! vasopressin receptor binding [Term] id: GO:0031897 name: Tic complex namespace: cellular_component def: "The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane." [PMID:12180471, PMID:12393016] synonym: "chloroplast inner membrane translocase complex" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0009706 ! chloroplast inner membrane [Term] id: GO:0031898 name: chromoplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:pz] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0031899 name: chromoplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma." [GOC:pz] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031900 name: chromoplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chromoplast envelope." [GOC:pz] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0046862 ! chromoplast membrane [Term] id: GO:0031901 name: early endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an early endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031902 name: late endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding a late endosome." [GOC:pz] is_a: GO:0010008 ! endosome membrane relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031903 name: microbody membrane namespace: cellular_component def: "The lipid bilayer surrounding a microbody." [GOC:mah] is_a: GO:0042579 ! microbody is_a: GO:0044438 ! microbody part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane [Term] id: GO:0031904 name: endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an endosome." [GOC:mah] xref: NIF_Subcellular:sao1547508851 is_a: GO:0044440 ! endosomal part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031905 name: early endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of an early endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005769 ! early endosome [Term] id: GO:0031906 name: late endosome lumen namespace: cellular_component def: "The volume enclosed by the membrane of a late endosome." [GOC:mah] is_a: GO:0031904 ! endosome lumen relationship: part_of GO:0005770 ! late endosome [Term] id: GO:0031907 name: microbody lumen namespace: cellular_component def: "The volume enclosed by the membranes of a microbody." [GOC:mah] is_a: GO:0044438 ! microbody part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031908 name: glyoxysomal lumen namespace: cellular_component def: "The volume enclosed by the membranes of a glyoxysome." [GOC:mah] is_a: GO:0005782 ! peroxisomal matrix [Term] id: GO:0031910 name: cytostome namespace: cellular_component def: "Stable, specialized structure for the ingestion of food by the cell into phagosomes." [PMID:10503189] xref: Wikipedia:Cytostome is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031911 name: cytoproct namespace: cellular_component def: "Stable, specialized structure for extrusion of waste by the cell into the surrounding medium." [PMID:10503189] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0031912 name: oral apparatus namespace: cellular_component def: "Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems." [PMID:10503189] comment: Note that this term refers to a subcellular structure characteristic of ciliate protozoans, and should not be confused with oral anatomical structures of multicellular animals. is_a: GO:0044464 ! cell part [Term] id: GO:0031913 name: contractile vacuole pore namespace: cellular_component def: "Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium." [PMID:10503189] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044433 ! cytoplasmic vesicle part is_a: GO:0044437 ! vacuolar part is_a: GO:0098797 ! plasma membrane protein complex relationship: part_of GO:0031164 ! contractile vacuolar membrane [Term] id: GO:0031914 name: negative regulation of synaptic plasticity namespace: biological_process def: "A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "down regulation of synaptic plasticity" EXACT [] synonym: "down-regulation of synaptic plasticity" EXACT [] synonym: "downregulation of synaptic plasticity" EXACT [] synonym: "inhibition of synaptic plasticity" NARROW [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031915 name: positive regulation of synaptic plasticity namespace: biological_process def: "A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers." [GOC:mah] synonym: "activation of synaptic plasticity" NARROW [] synonym: "stimulation of synaptic plasticity" NARROW [] synonym: "up regulation of synaptic plasticity" EXACT [] synonym: "up-regulation of synaptic plasticity" EXACT [] synonym: "upregulation of synaptic plasticity" EXACT [] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031916 name: regulation of synaptic metaplasticity namespace: biological_process def: "A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] is_a: GO:0048167 ! regulation of synaptic plasticity [Term] id: GO:0031917 name: negative regulation of synaptic metaplasticity namespace: biological_process def: "A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "down regulation of synaptic metaplasticity" EXACT [] synonym: "down-regulation of synaptic metaplasticity" EXACT [] synonym: "downregulation of synaptic metaplasticity" EXACT [] synonym: "inhibition of synaptic metaplasticity" NARROW [] is_a: GO:0031914 ! negative regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031918 name: positive regulation of synaptic metaplasticity namespace: biological_process def: "A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require." [GOC:mah, PMID:8658594] synonym: "activation of synaptic metaplasticity" NARROW [] synonym: "stimulation of synaptic metaplasticity" NARROW [] synonym: "up regulation of synaptic metaplasticity" EXACT [] synonym: "up-regulation of synaptic metaplasticity" EXACT [] synonym: "upregulation of synaptic metaplasticity" EXACT [] is_a: GO:0031915 ! positive regulation of synaptic plasticity is_a: GO:0031916 ! regulation of synaptic metaplasticity [Term] id: GO:0031919 name: vitamin B6 transport namespace: biological_process def: "The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071702 ! organic substance transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0031920 name: pyridoxal transport namespace: biological_process def: "The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015695 ! organic cation transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031921 name: pyridoxal phosphate transport namespace: biological_process def: "The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0015711 ! organic anion transport is_a: GO:0015748 ! organophosphate ester transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051182 ! coenzyme transport [Term] id: GO:0031922 name: pyridoxamine transport namespace: biological_process def: "The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015695 ! organic cation transport is_a: GO:0015696 ! ammonium transport is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport [Term] id: GO:0031923 name: pyridoxine transport namespace: biological_process def: "The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0015850 ! organic hydroxy compound transport is_a: GO:0031919 ! vitamin B6 transport is_a: GO:0051181 ! cofactor transport [Term] id: GO:0031924 name: vitamin B6 transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other." [GOC:mah] synonym: "vitamin B6 transporter activity" RELATED [] is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0031925 name: pyridoxal transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxal transporter activity" BROAD [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0031926 name: pyridoxal phosphate transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6." [GOC:mah] is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051185 ! coenzyme transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0031927 name: pyridoxamine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] is_a: GO:0008519 ! ammonium transmembrane transporter activity is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0031928 name: pyridoxine transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [GOC:mah] synonym: "pyridoxine transporter activity" BROAD [] is_a: GO:0031924 ! vitamin B6 transmembrane transporter activity is_a: GO:0051184 ! cofactor transmembrane transporter activity is_a: GO:1901618 ! organic hydroxy compound transmembrane transporter activity [Term] id: GO:0031929 name: TOR signaling namespace: biological_process def: "A series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors." [PMID:12372295] comment: Note that this term should not be confused with 'torso signaling pathway ; GO:0008293', although torso is abbreviated 'tor'. synonym: "target of rapamycin signaling pathway" EXACT [] synonym: "target of rapamycin signalling pathway" EXACT [] synonym: "TOR signal transduction" EXACT [GOC:signaling] synonym: "TOR signaling cascade" RELATED [GOC:signaling] synonym: "TOR signaling pathway" EXACT [] synonym: "TOR signalling pathway" EXACT [] is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0031930 name: mitochondria-nucleus signaling pathway namespace: biological_process def: "A series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function." [GOC:jh, PMID:15068799] synonym: "mitochondria-nucleus signal transduction" EXACT [GOC:signaling] synonym: "mitochondrial signaling pathway" EXACT [] synonym: "mitochondrial signalling pathway" EXACT [] synonym: "retrograde response" EXACT [] is_a: GO:0007165 ! signal transduction [Term] id: GO:0031931 name: TORC1 complex namespace: cellular_component def: "A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p." [GOC:jh, PMID:15780592, PMID:16469695, PMID:21548787] synonym: "dTOR/dRaptor complex" NARROW [PMID:17183368] synonym: "dTORC1" NARROW [PMID:17183368] synonym: "mTORC1" NARROW [PMID:18765678, PMID:21548787] synonym: "nutrient sensitive complex" EXACT [] synonym: "rapamycin and nutrient-sensitive TOR complex" EXACT [PMID:21548787] synonym: "TOR complex 1" EXACT [] synonym: "TORC 1 complex" EXACT [] synonym: "TORC1" EXACT [PMID:21548787] xref: Wikipedia:MTORC1 is_a: GO:0032991 ! protein-containing complex is_a: GO:0038201 ! TOR complex [Term] id: GO:0031932 name: TORC2 complex namespace: cellular_component def: "A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p." [GOC:bf, GOC:jh, PMID:14736892, PMID:15780592, PMID:16469695, PMID:21548787] synonym: "mTORC2" NARROW [PMID:20496258, PMID:21548787] synonym: "rapamycin and nutrient-insensitive TOR complex" EXACT [PMID:21548787] synonym: "TOR complex 2" EXACT [] synonym: "TORC 2 complex" EXACT [] synonym: "TORC2" EXACT [PMID:21548787] xref: Wikipedia:MTORC1 is_a: GO:0032991 ! protein-containing complex is_a: GO:0038201 ! TOR complex [Term] id: GO:0031933 name: telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres." [GOC:mah] synonym: "telomeric chromatin" BROAD [GOC:pr] is_a: GO:0000792 ! heterochromatin relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0031934 name: mating-type region heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at silenced mating-type loci." [GOC:mah] is_a: GO:0000792 ! heterochromatin [Term] id: GO:0031935 name: regulation of chromatin silencing namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing." [GOC:mah] synonym: "regulation of heterochromatic silencing" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated is_a: GO:0060968 ! regulation of gene silencing is_a: GO:1902275 ! regulation of chromatin organization relationship: regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031936 name: negative regulation of chromatin silencing namespace: biological_process alt_id: GO:0006345 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "down regulation of chromatin silencing" EXACT [] synonym: "down-regulation of chromatin silencing" EXACT [] synonym: "downregulation of chromatin silencing" EXACT [] synonym: "inhibition of chromatin silencing" NARROW [] synonym: "loss of chromatin silencing" EXACT [] synonym: "negative regulation of heterochromatic silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:0045815 ! positive regulation of gene expression, epigenetic is_a: GO:0045893 ! positive regulation of transcription, DNA-templated is_a: GO:0060969 ! negative regulation of gene silencing is_a: GO:1905268 ! negative regulation of chromatin organization relationship: negatively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031937 name: positive regulation of chromatin silencing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing." [GOC:mah] synonym: "activation of chromatin silencing" NARROW [] synonym: "positive regulation of heterochromatic silencing" EXACT [] synonym: "stimulation of chromatin silencing" NARROW [] synonym: "up regulation of chromatin silencing" EXACT [] synonym: "up-regulation of chromatin silencing" EXACT [] synonym: "upregulation of chromatin silencing" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing is_a: GO:1905269 ! positive regulation of chromatin organization relationship: positively_regulates GO:0006342 ! chromatin silencing [Term] id: GO:0031938 name: regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that affects the rate, extent or location of chromatin silencing at telomeres." [GOC:mah] synonym: "regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031935 ! regulation of chromatin silencing relationship: regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031939 name: negative regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "down regulation of chromatin silencing at telomere" EXACT [] synonym: "down-regulation of chromatin silencing at telomere" EXACT [] synonym: "downregulation of chromatin silencing at telomere" EXACT [] synonym: "inhibition of chromatin silencing at telomere" NARROW [] synonym: "negative regulation of heterochromatic silencing at telomere" EXACT [] is_a: GO:0031936 ! negative regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere relationship: negatively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031940 name: positive regulation of chromatin silencing at telomere namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chromatin silencing at telomeres." [GOC:mah] synonym: "activation of chromatin silencing at telomere" NARROW [] synonym: "positive regulation of heterochromatic silencing at telomere" EXACT [] synonym: "stimulation of chromatin silencing at telomere" NARROW [] synonym: "up regulation of chromatin silencing at telomere" EXACT [] synonym: "up-regulation of chromatin silencing at telomere" EXACT [] synonym: "upregulation of chromatin silencing at telomere" EXACT [] is_a: GO:0031937 ! positive regulation of chromatin silencing is_a: GO:0031938 ! regulation of chromatin silencing at telomere relationship: positively_regulates GO:0006348 ! chromatin silencing at telomere [Term] id: GO:0031941 name: filamentous actin namespace: cellular_component def: "A two-stranded helical polymer of the protein actin." [GOC:mah] comment: Note that this term refers only to the actin portion of a microfilament, and does not encompass associated proteins. See also the cellular component term 'actin filament ; GO:0005884'. synonym: "F-actin" EXACT [] xref: Wikipedia:Actin is_a: GO:0032991 ! protein-containing complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005884 ! actin filament [Term] id: GO:0031942 name: i-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases." [PMID:16247555, PMID:16267274] is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0031943 name: regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031944 name: negative regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid metabolic process" EXACT [] synonym: "down-regulation of glucocorticoid metabolic process" EXACT [] synonym: "downregulation of glucocorticoid metabolic process" EXACT [] synonym: "inhibition of glucocorticoid metabolic process" NARROW [] synonym: "negative regulation of glucocorticoid metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process relationship: negatively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031945 name: positive regulation of glucocorticoid metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid metabolic process" NARROW [] synonym: "positive regulation of glucocorticoid metabolism" EXACT [] synonym: "stimulation of glucocorticoid metabolic process" NARROW [] synonym: "up regulation of glucocorticoid metabolic process" EXACT [] synonym: "up-regulation of glucocorticoid metabolic process" EXACT [] synonym: "upregulation of glucocorticoid metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process relationship: positively_regulates GO:0008211 ! glucocorticoid metabolic process [Term] id: GO:0031946 name: regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process relationship: regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031947 name: negative regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "down-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "downregulation of glucocorticoid biosynthetic process" EXACT [] synonym: "inhibition of glucocorticoid biosynthetic process" NARROW [] is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process relationship: negatively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031948 name: positive regulation of glucocorticoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid biosynthetic process" NARROW [] synonym: "stimulation of glucocorticoid biosynthetic process" NARROW [] synonym: "up regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "up-regulation of glucocorticoid biosynthetic process" EXACT [] synonym: "upregulation of glucocorticoid biosynthetic process" EXACT [] is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031946 ! regulation of glucocorticoid biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process relationship: positively_regulates GO:0006704 ! glucocorticoid biosynthetic process [Term] id: GO:0031949 name: regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0031943 ! regulation of glucocorticoid metabolic process is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031950 name: negative regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "down regulation of glucocorticoid catabolic process" EXACT [] synonym: "down-regulation of glucocorticoid catabolic process" EXACT [] synonym: "downregulation of glucocorticoid catabolic process" EXACT [] synonym: "inhibition of glucocorticoid catabolic process" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031944 ! negative regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031951 name: positive regulation of glucocorticoid catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids." [GOC:mah] synonym: "activation of glucocorticoid catabolic process" NARROW [] synonym: "stimulation of glucocorticoid catabolic process" NARROW [] synonym: "up regulation of glucocorticoid catabolic process" EXACT [] synonym: "up-regulation of glucocorticoid catabolic process" EXACT [] synonym: "upregulation of glucocorticoid catabolic process" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031945 ! positive regulation of glucocorticoid metabolic process is_a: GO:0031949 ! regulation of glucocorticoid catabolic process is_a: GO:0050996 ! positive regulation of lipid catabolic process relationship: positively_regulates GO:0006713 ! glucocorticoid catabolic process [Term] id: GO:0031952 name: regulation of protein autophosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001932 ! regulation of protein phosphorylation relationship: regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031953 name: negative regulation of protein autophosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "down regulation of protein amino acid autophosphorylation" EXACT [] synonym: "down-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "downregulation of protein amino acid autophosphorylation" EXACT [] synonym: "inhibition of protein amino acid autophosphorylation" NARROW [] synonym: "negative regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] is_a: GO:0001933 ! negative regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation relationship: negatively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031954 name: positive regulation of protein autophosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues." [GOC:mah] synonym: "activation of protein amino acid autophosphorylation" NARROW [] synonym: "positive regulation of protein amino acid autophosphorylation" EXACT [GOC:bf] synonym: "stimulation of protein amino acid autophosphorylation" NARROW [] synonym: "up regulation of protein amino acid autophosphorylation" EXACT [] synonym: "up-regulation of protein amino acid autophosphorylation" EXACT [] synonym: "upregulation of protein amino acid autophosphorylation" EXACT [] is_a: GO:0001934 ! positive regulation of protein phosphorylation is_a: GO:0031952 ! regulation of protein autophosphorylation relationship: positively_regulates GO:0046777 ! protein autophosphorylation [Term] id: GO:0031955 name: short-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6." [CHEBI:26666, EC:6.2.1.3, GOC:mah] synonym: "short-chain fatty acid activation" RELATED [] synonym: "short-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] synonym: "short-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031956 name: medium-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12." [CHEBI:59554, EC:6.2.1.3, GOC:mah] synonym: "medium-chain fatty acid activation" RELATED [] synonym: "medium-chain fatty-acid-CoA ligase activity" EXACT [GOC:bf] synonym: "medium-chain-fatty-acid-CoA ligase activity" EXACT [] is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031957 name: very long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22." [CHEBI:27283, EC:6.2.1.3, GOC:mah] synonym: "very-long-chain fatty acid activation" RELATED [] synonym: "very-long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "very-long-chain-fatty-acid-CoA ligase activity" EXACT [] xref: reactome:R-HSA-5695957 "ACSBG1,2 ligates CoA-SH to VLCFA, forming VLCFA-CoA" xref: reactome:R-HSA-5696007 "ACSF3 ligates CoA-SH to VLCFA" xref: reactome:R-HSA-8875077 "SLC27A3 ligates CoA-SH to VLCFA" is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0031958 name: corticosteroid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a corticosteroid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "corticosteroid receptor signalling pathway" EXACT [] is_a: GO:0030518 ! intracellular steroid hormone receptor signaling pathway [Term] id: GO:0031959 name: mineralocorticoid receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of a mineralocorticoid binding to its receptor." [GOC:mah, PMID:11027914, PMID:12606724] synonym: "mineralocorticoid receptor signalling pathway" EXACT [] is_a: GO:0031958 ! corticosteroid receptor signaling pathway [Term] id: GO:0031960 name: response to corticosteroid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids." [GOC:mah, PMID:11027914] synonym: "response to corticosteroid stimulus" EXACT [GOC:dos] is_a: GO:0048545 ! response to steroid hormone [Term] id: GO:0031961 name: cortisol receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a cortisol receptor." [GOC:mah, PMID:12511169] is_a: GO:0035259 ! glucocorticoid receptor binding [Term] id: GO:0031962 name: mineralocorticoid receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mineralocorticoid receptor." [GOC:mah, PMID:12511169] is_a: GO:0016922 ! nuclear receptor binding is_a: GO:0035258 ! steroid hormone receptor binding [Term] id: GO:0031963 name: cortisol receptor activity namespace: molecular_function def: "Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function." [GOC:mah, PMID:12511169] comment: For cortisol receptors that act in the nucleus to regulate transcription, consider also annotating to the terms: ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity ; GO:0038049' or ligand-activated RNA polymerase II transcription factor binding transcription factor activity ; GO:0038049'. is_a: GO:0004883 ! glucocorticoid receptor activity [Term] id: GO:0031964 name: beta-alanyl-histamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N-beta-alanyl histamine + H2O = histamine + beta-alanine." [GOC:rc, PMID:16299587] synonym: "carcinine hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0031965 name: nuclear membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space." [GOC:mah, GOC:pz] xref: NIF_Subcellular:sao1687101204 is_a: GO:0031090 ! organelle membrane is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0031966 name: mitochondrial membrane namespace: cellular_component def: "Either of the lipid bilayers that surround the mitochondrion and form the mitochondrial envelope." [GOC:mah, NIF_Subcellular:sao1045389829] xref: NIF_Subcellular:sao1045389829 is_a: GO:0031090 ! organelle membrane is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0031967 name: organelle envelope namespace: cellular_component def: "A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes." [GOC:mah, GOC:pz] subset: goslim_mouse is_a: GO:0031975 ! envelope is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031968 name: organelle outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope." [GOC:mah] is_a: GO:0019867 ! outer membrane is_a: GO:0044424 ! intracellular part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031969 name: chloroplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a chloroplast and form the chloroplast envelope." [GOC:mah, GOC:pz] xref: Wikipedia:Chloroplast_membrane is_a: GO:0042170 ! plastid membrane is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031970 name: organelle envelope lumen namespace: cellular_component def: "The region between the inner and outer lipid bilayers of an organelle envelope." [GOC:mah] synonym: "organelle intermembrane space" EXACT [] is_a: GO:0044446 ! intracellular organelle part is_a: GO:0070013 ! intracellular organelle lumen relationship: part_of GO:0031967 ! organelle envelope [Term] id: GO:0031972 name: chloroplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chloroplast envelope." [GOC:mah] synonym: "chloroplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009941 ! chloroplast envelope [Term] id: GO:0031973 name: chromoplast intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of a chromoplast envelope." [GOC:mah] synonym: "chromoplast envelope lumen" EXACT [] is_a: GO:0009529 ! plastid intermembrane space relationship: part_of GO:0031898 ! chromoplast envelope [Term] id: GO:0031974 name: membrane-enclosed lumen namespace: cellular_component def: "The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen." [GOC:add, GOC:mah] is_a: GO:0005575 ! cellular_component [Term] id: GO:0031975 name: envelope namespace: cellular_component def: "A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers." [GOC:mah, GOC:pz] is_a: GO:0044464 ! cell part [Term] id: GO:0031976 name: plastid thylakoid namespace: cellular_component def: "Any thylakoid within a plastid." [GOC:pz] is_a: GO:0009579 ! thylakoid is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044435 ! plastid part [Term] id: GO:0031977 name: thylakoid lumen namespace: cellular_component def: "The volume enclosed by a thylakoid membrane." [GOC:mah, GOC:pz] is_a: GO:0044436 ! thylakoid part [Term] id: GO:0031978 name: plastid thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plastid thylakoid membrane." [GOC:mah] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0044435 ! plastid part relationship: part_of GO:0031976 ! plastid thylakoid [Term] id: GO:0031979 name: plasma membrane-derived thylakoid lumen namespace: cellular_component def: "The volume enclosed by a plasma membrane-derived thylakoid." [GOC:mah, GOC:mtg_sensu] synonym: "plasma membrane thylakoid lumen" EXACT [] is_a: GO:0031977 ! thylakoid lumen is_a: GO:0044459 ! plasma membrane part is_a: GO:0060205 ! cytoplasmic vesicle lumen relationship: part_of GO:0030075 ! bacterial thylakoid [Term] id: GO:0031981 name: nuclear lumen namespace: cellular_component def: "The volume enclosed by the nuclear inner membrane." [GOC:mah, GOC:pz] is_a: GO:0044428 ! nuclear part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0031982 name: vesicle namespace: cellular_component alt_id: GO:0031988 def: "Any small, fluid-filled, spherical organelle enclosed by membrane." [GOC:mah, GOC:pz, GOC:vesicles] subset: goslim_pir synonym: "membrane-bounded vesicle" RELATED [] synonym: "membrane-enclosed vesicle" RELATED [] xref: NIF_Subcellular:sao221389602 xref: Wikipedia:Vesicle_(biology) is_a: GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031983 name: vesicle lumen namespace: cellular_component def: "The volume enclosed by the membrane or protein that forms a vesicle." [GOC:mah, GOC:vesicles] xref: NIF_Subcellular:sao797538226 is_a: GO:0043233 ! organelle lumen relationship: part_of GO:0031982 ! vesicle [Term] id: GO:0031984 name: organelle subcompartment namespace: cellular_component def: "A compartment that consists of a lumen and an enclosing membrane, and is part of an organelle." [GOC:mah, GOC:pz] comment: Note that this term refers to membrane-bounded compartments that are not considered organelles in their own right, but form parts of larger organelles. synonym: "suborganelle compartment" EXACT [] is_a: GO:0044446 ! intracellular organelle part relationship: part_of GO:0043227 ! membrane-bounded organelle [Term] id: GO:0031985 name: Golgi cisterna namespace: cellular_component def: "Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex." [GOC:mah] synonym: "Golgi lamellae" RELATED [NIF_Subcellular:sao561419532] xref: NIF_Subcellular:sao561419532 is_a: GO:0098791 ! Golgi subcompartment relationship: part_of GO:0005795 ! Golgi stack [Term] id: GO:0031986 name: proteinoplast namespace: cellular_component def: "A leucoplast in which protein is stored." [GOC:pz] xref: Wikipedia:Proteinoplast is_a: GO:0009516 ! leucoplast [Term] id: GO:0031987 name: locomotion involved in locomotory behavior namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement." [GOC:mah] synonym: "locomotion during locomotory behaviour" EXACT [] is_a: GO:0040011 ! locomotion relationship: part_of GO:0007626 ! locomotory behavior [Term] id: GO:0031989 name: bombesin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a bombesin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "bombesin receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G protein-coupled receptor signaling pathway [Term] id: GO:0031990 name: mRNA export from nucleus in response to heat stress namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export." [GOC:mah, GOC:vw] synonym: "mRNA export from cell nucleus during heat stress" EXACT [] synonym: "mRNA export from nucleus during heat stress" RELATED [GOC:dph, GOC:tb] is_a: GO:0006406 ! mRNA export from nucleus is_a: GO:0034605 ! cellular response to heat [Term] id: GO:0031991 name: regulation of actomyosin contractile ring contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of contractile ring contraction involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "regulation of contractile ring contraction involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process is_a: GO:0032954 ! regulation of cytokinetic process is_a: GO:0110020 ! regulation of actomyosin structure organization relationship: regulates GO:0000916 ! actomyosin contractile ring contraction [Term] id: GO:0031992 name: energy transducer activity namespace: molecular_function def: "The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell." [GOC:go_curators] subset: goslim_pir synonym: "light harvesting activity" RELATED [] synonym: "photon capture" RELATED [] is_a: GO:0060089 ! molecular transducer activity [Term] id: GO:0031993 name: light transducer activity namespace: molecular_function def: "Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell." [GOC:mah, GOC:mlg] is_a: GO:0031992 ! energy transducer activity [Term] id: GO:0031994 name: insulin-like growth factor I binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor I." [GOC:mah] subset: goslim_chembl synonym: "IGF-I binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031995 name: insulin-like growth factor II binding namespace: molecular_function def: "Interacting selectively and non-covalently with insulin-like growth factor II." [GOC:mah] subset: goslim_chembl synonym: "IGF-II binding" EXACT [] is_a: GO:0005520 ! insulin-like growth factor binding [Term] id: GO:0031996 name: thioesterase binding namespace: molecular_function def: "Interacting selectively and non-covalently with any thioesterase enzyme." [GOC:dl] synonym: "thiolesterase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0031997 name: N-terminal myristoylation domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin." [GOC:dl, GOC:jsg, PMID:15632291] is_a: GO:0047485 ! protein N-terminus binding [Term] id: GO:0031998 name: regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of fatty acid bbeta-oxidation." [GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0046320 ! regulation of fatty acid oxidation is_a: GO:0050994 ! regulation of lipid catabolic process relationship: regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0031999 name: negative regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "down regulation of fatty acid beta-oxidation" EXACT [] synonym: "down-regulation of fatty acid beta-oxidation" EXACT [] synonym: "downregulation of fatty acid beta-oxidation" EXACT [] synonym: "inhibition of fatty acid beta-oxidation" NARROW [] is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046322 ! negative regulation of fatty acid oxidation is_a: GO:0050995 ! negative regulation of lipid catabolic process relationship: negatively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032000 name: positive regulation of fatty acid beta-oxidation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of fatty acid beta-oxidation." [GOC:mah] synonym: "activation of fatty acid beta-oxidation" NARROW [] synonym: "stimulation of fatty acid beta-oxidation" NARROW [] synonym: "up regulation of fatty acid beta-oxidation" EXACT [] synonym: "up-regulation of fatty acid beta-oxidation" EXACT [] synonym: "upregulation of fatty acid beta-oxidation" EXACT [] is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0031998 ! regulation of fatty acid beta-oxidation is_a: GO:0046321 ! positive regulation of fatty acid oxidation is_a: GO:0050996 ! positive regulation of lipid catabolic process relationship: positively_regulates GO:0006635 ! fatty acid beta-oxidation [Term] id: GO:0032001 name: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan." [EC:2.4.1.24] synonym: "1,4-alpha-D-glucan 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan(D-glucose) 6-alpha-D-glucosyltransferase activity" EXACT [] synonym: "D-glucosyltransferase" BROAD [] synonym: "oligoglucan-branching glycosyltransferase activity" RELATED [EC:2.4.1.24] synonym: "T-enzyme" NARROW [] xref: EC:2.4.1.24 xref: MetaCyc:2.4.1.24-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0032002 name: interleukin-28 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1)." [GOC:rph] synonym: "IL-28 receptor complex" EXACT [GOC:add] is_a: GO:0098802 ! plasma membrane receptor complex relationship: part_of GO:0005887 ! integral component of plasma membrane [Term] id: GO:0032003 name: interleukin-28 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-28 receptor." [GOC:rph] synonym: "IL-28" NARROW [] synonym: "interleukin-28 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032005 name: signal transduction involved in positive regulation of conjugation with cellular fusion namespace: biological_process def: "The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion." [GOC:mah] is_a: GO:0007165 ! signal transduction is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0032006 name: regulation of TOR signaling namespace: biological_process def: "Any process that modulates the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "regulation of target of rapamycin signaling pathway" EXACT [] synonym: "regulation of target of rapamycin signalling pathway" EXACT [] synonym: "regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "regulation of TOR signaling pathway" EXACT [] synonym: "regulation of TOR signalling pathway" EXACT [] is_a: GO:1902531 ! regulation of intracellular signal transduction relationship: regulates GO:0031929 ! TOR signaling [Term] id: GO:0032007 name: negative regulation of TOR signaling namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "down regulation of TOR signaling pathway" EXACT [] synonym: "down-regulation of TOR signaling pathway" EXACT [] synonym: "downregulation of TOR signaling pathway" EXACT [] synonym: "inhibition of TOR signaling pathway" NARROW [] synonym: "negative regulation of target of rapamycin signaling pathway" EXACT [] synonym: "negative regulation of target of rapamycin signalling pathway" EXACT [] synonym: "negative regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "negative regulation of TOR signaling pathway" EXACT [] synonym: "negative regulation of TOR signalling pathway" EXACT [] is_a: GO:0032006 ! regulation of TOR signaling is_a: GO:1902532 ! negative regulation of intracellular signal transduction relationship: negatively_regulates GO:0031929 ! TOR signaling [Term] id: GO:0032008 name: positive regulation of TOR signaling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of TOR signaling." [GOC:mah] synonym: "activation of TOR signaling pathway" NARROW [] synonym: "positive regulation of target of rapamycin signaling pathway" EXACT [] synonym: "positive regulation of target of rapamycin signalling pathway" EXACT [] synonym: "positive regulation of TOR signaling cascade" RELATED [GOC:signaling] synonym: "positive regulation of TOR signaling pathway" EXACT [] synonym: "positive regulation of TOR signalling pathway" EXACT [] synonym: "stimulation of TOR signaling pathway" NARROW [] synonym: "up regulation of TOR signaling pathway" EXACT [] synonym: "up-regulation of TOR signaling pathway" EXACT [] synonym: "upregulation of TOR signaling pathway" EXACT [] is_a: GO:0032006 ! regulation of TOR signaling is_a: GO:1902533 ! positive regulation of intracellular signal transduction relationship: positively_regulates GO:0031929 ! TOR signaling [Term] id: GO:0032009 name: early phagosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis." [GOC:mah, PMID:12388753] synonym: "early phagocytic vesicle" EXACT [] is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032010 name: phagolysosome namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes." [GOC:mah, PMID:12388753] synonym: "late phagocytic vesicle" RELATED [] synonym: "late phagosome" RELATED [] xref: Wikipedia:Phagolysosome is_a: GO:0005767 ! secondary lysosome is_a: GO:0045335 ! phagocytic vesicle [Term] id: GO:0032011 name: ARF protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032012 name: regulation of ARF protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032013 name: negative regulation of ARF protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "down regulation of ARF protein signal transduction" EXACT [] synonym: "down-regulation of ARF protein signal transduction" EXACT [] synonym: "downregulation of ARF protein signal transduction" EXACT [] synonym: "inhibition of ARF protein signal transduction" NARROW [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032014 name: positive regulation of ARF protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction." [GOC:mah] synonym: "activation of ARF protein signal transduction" NARROW [] synonym: "stimulation of ARF protein signal transduction" NARROW [] synonym: "up regulation of ARF protein signal transduction" EXACT [] synonym: "up-regulation of ARF protein signal transduction" EXACT [] synonym: "upregulation of ARF protein signal transduction" EXACT [] is_a: GO:0032012 ! regulation of ARF protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0032011 ! ARF protein signal transduction [Term] id: GO:0032015 name: regulation of Ran protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032016 name: negative regulation of Ran protein signal transduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "down regulation of Ran protein signal transduction" EXACT [] synonym: "down-regulation of Ran protein signal transduction" EXACT [] synonym: "downregulation of Ran protein signal transduction" EXACT [] synonym: "inhibition of Ran protein signal transduction" NARROW [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046580 ! negative regulation of Ras protein signal transduction relationship: negatively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032017 name: positive regulation of Ran protein signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction." [GOC:mah] synonym: "activation of Ran protein signal transduction" NARROW [] synonym: "stimulation of Ran protein signal transduction" NARROW [] synonym: "up regulation of Ran protein signal transduction" EXACT [] synonym: "up-regulation of Ran protein signal transduction" EXACT [] synonym: "upregulation of Ran protein signal transduction" EXACT [] is_a: GO:0032015 ! regulation of Ran protein signal transduction is_a: GO:0046579 ! positive regulation of Ras protein signal transduction relationship: positively_regulates GO:0031291 ! Ran protein signal transduction [Term] id: GO:0032018 name: 2-methylbutanol:NADP oxidoreductase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanol + NADP+ = 2-methylbutanal + NADPH + H+." [GOC:mah, PMID:12210903] synonym: "2-methylbutanal reductase (NADP) activity" EXACT [] synonym: "2-methylbutyraldehyde reductase (NADP) activity" EXACT [] is_a: GO:0008106 ! alcohol dehydrogenase (NADP+) activity [Term] id: GO:0032019 name: mitochondrial cloud namespace: cellular_component def: "A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material." [PMID:6541166] synonym: "Balbiani body" EXACT [] synonym: "mitochondrial aggregate" RELATED [] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032020 name: ISG15-protein conjugation namespace: biological_process def: "The covalent addition to a protein of ISG15, a ubiquitin-like protein." [GOC:mah] is_a: GO:0006464 ! cellular protein modification process [Term] id: GO:0032021 name: NELF complex namespace: cellular_component def: "A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing." [PMID:12612062] synonym: "negative elongation factor complex" EXACT [] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032023 name: trypsinogen activation namespace: biological_process def: "The proteolytic processing of trypsinogen to the active form, trypsin." [GOC:mah] synonym: "cleavage of trypsinogen to trypsin" EXACT [] is_a: GO:0031638 ! zymogen activation [Term] id: GO:0032024 name: positive regulation of insulin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of insulin." [GOC:mah] synonym: "activation of insulin secretion" NARROW [] synonym: "stimulation of insulin secretion" NARROW [] synonym: "up regulation of insulin secretion" EXACT [] synonym: "up-regulation of insulin secretion" EXACT [] synonym: "upregulation of insulin secretion" EXACT [] is_a: GO:0050714 ! positive regulation of protein secretion is_a: GO:0050796 ! regulation of insulin secretion is_a: GO:0090277 ! positive regulation of peptide hormone secretion relationship: positively_regulates GO:0030073 ! insulin secretion [Term] id: GO:0032025 name: response to cobalt ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032026 name: response to magnesium ion namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus." [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0032027 name: myosin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032028 name: myosin head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032029 name: myosin tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin heavy chain." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032030 name: myosin I light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032027 ! myosin light chain binding [Term] id: GO:0032031 name: myosin I head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032032 name: myosin I tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin I heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032037 ! myosin I heavy chain binding [Term] id: GO:0032033 name: myosin II light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a light chain of a myosin II complex." [GOC:mah] is_a: GO:0032027 ! myosin light chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032034 name: myosin II head/neck binding namespace: molecular_function def: "Interacting selectively and non-covalently with the head/neck region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032028 ! myosin head/neck binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032035 name: myosin II tail binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tail region of a myosin II heavy chain." [GOC:mah] is_a: GO:0032029 ! myosin tail binding is_a: GO:0032038 ! myosin II heavy chain binding [Term] id: GO:0032036 name: myosin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin complex." [GOC:mah] is_a: GO:0017022 ! myosin binding [Term] id: GO:0032037 name: myosin I heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin I complex." [GOC:mah] is_a: GO:0017024 ! myosin I binding is_a: GO:0032036 ! myosin heavy chain binding [Term] id: GO:0032038 name: myosin II heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heavy chain of a myosin II complex." [GOC:mah] is_a: GO:0032036 ! myosin heavy chain binding is_a: GO:0045159 ! myosin II binding [Term] id: GO:0032039 name: integrator complex namespace: cellular_component def: "A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II." [PMID:16239144] comment: Changed parents, see https://github.com/geneontology/go-ontology/issues/15979 is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032040 name: small-subunit processome namespace: cellular_component def: "A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins." [GOC:krc, GOC:vw, PMID:12068309, PMID:12957375, PMID:15120992, PMID:15590835] synonym: "small subunit processome" EXACT [] synonym: "SSU processome" EXACT [] is_a: GO:0030684 ! preribosome [Term] id: GO:0032041 name: NAD-dependent histone deacetylase activity (H3-K14 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] xref: EC:3.5.1.98 is_a: GO:0017136 ! NAD-dependent histone deacetylase activity is_a: GO:0031078 ! histone deacetylase activity (H3-K14 specific) [Term] id: GO:0032042 name: mitochondrial DNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA metabolism" EXACT [] synonym: "mtDNA metabolic process" EXACT [] synonym: "mtDNA metabolism" EXACT [] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0000002 ! mitochondrial genome maintenance [Term] id: GO:0032043 name: mitochondrial DNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mitochondrial DNA." [GOC:mah] synonym: "mitochondrial DNA breakdown" EXACT [] synonym: "mitochondrial DNA catabolism" EXACT [] synonym: "mitochondrial DNA degradation" EXACT [] synonym: "mtDNA breakdown" EXACT [] synonym: "mtDNA catabolic process" EXACT [] synonym: "mtDNA catabolism" EXACT [] synonym: "mtDNA degradation" EXACT [] is_a: GO:0006308 ! DNA catabolic process is_a: GO:0032042 ! mitochondrial DNA metabolic process [Term] id: GO:0032044 name: DSIF complex namespace: cellular_component def: "A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes." [PMID:12242279, PMID:12653964, PMID:12676794, PMID:16581788, PMID:19460865] synonym: "5,6-Dichloro-1-beta-D-ribofuranosylbenzimidazole sensitivity inducing factor complex" EXACT [] synonym: "DRB sensitivity inducing factor complex" EXACT [] synonym: "Spt4-Spt5 complex" EXACT [] synonym: "Spt5-Spt4 complex" EXACT [GOC:vw] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032045 name: guanyl-nucleotide exchange factor complex namespace: cellular_component def: "A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase." [GOC:mah] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032046 name: micropexophagy-specific membrane apparatus namespace: cellular_component def: "A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole." [PMID:15563611] synonym: "micropexophagic apparatus" EXACT [] synonym: "MIPA" EXACT [] is_a: GO:0031984 ! organelle subcompartment is_a: GO:0044437 ! vacuolar part [Term] id: GO:0032047 name: mitosome namespace: cellular_component def: "A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria." [GOC:giardia, PMID:10361303, PMID:14614504, PMID:24316280] comment: In Giardia species, mitosomes are sometimes present between the two nuclei. synonym: "crypton" EXACT [] xref: Wikipedia:Mitosome is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032048 name: cardiolipin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] synonym: "cardiolipin metabolism" EXACT [] synonym: "diphosphatidylglycerol metabolic process" RELATED [] synonym: "diphosphatidylglycerol metabolism" RELATED [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process [Term] id: GO:0032049 name: cardiolipin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol." [CHEBI:28494, GOC:mah] synonym: "diphosphatidylglycerol biosynthesis" RELATED [] synonym: "diphosphatidylglycerol biosynthetic process" RELATED [] xref: MetaCyc:PWY-5269 is_a: GO:0006655 ! phosphatidylglycerol biosynthetic process is_a: GO:0032048 ! cardiolipin metabolic process [Term] id: GO:0032050 name: clathrin heavy chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin heavy chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032051 name: clathrin light chain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a clathrin light chain." [GOC:mah] is_a: GO:0030276 ! clathrin binding [Term] id: GO:0032052 name: bile acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:rph] is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0032053 name: ciliary basal body organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum)." [GOC:cilia, GOC:dph, GOC:jl, GOC:krc, GOC:mah, PMID:9889124] synonym: "microtubule basal body organisation" BROAD [GOC:mah] synonym: "microtubule basal body organization" BROAD [] synonym: "microtubule basal body organization and biogenesis" RELATED [GOC:mah] is_a: GO:0031023 ! microtubule organizing center organization is_a: GO:0044782 ! cilium organization [Term] id: GO:0032055 name: negative regulation of translation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation in response to stress" EXACT [] synonym: "down-regulation of translation in response to stress" EXACT [] synonym: "downregulation of translation in response to stress" EXACT [] synonym: "inhibition of translation in response to stress" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0043555 ! regulation of translation in response to stress [Term] id: GO:0032056 name: positive regulation of translation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation in response to stress" NARROW [] synonym: "stimulation of translation in response to stress" NARROW [] synonym: "up regulation of translation in response to stress" EXACT [] synonym: "up-regulation of translation in response to stress" EXACT [] synonym: "upregulation of translation in response to stress" EXACT [] is_a: GO:0043555 ! regulation of translation in response to stress is_a: GO:0045727 ! positive regulation of translation [Term] id: GO:0032057 name: negative regulation of translational initiation in response to stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "down regulation of translation initiation in response to stress" EXACT [] synonym: "down-regulation of translation initiation in response to stress" EXACT [] synonym: "downregulation of translation initiation in response to stress" EXACT [] synonym: "inhibition of translation initiation in response to stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045947 ! negative regulation of translational initiation [Term] id: GO:0032058 name: positive regulation of translational initiation in response to stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress." [GOC:mah] synonym: "activation of translation initiation in response to stress" NARROW [] synonym: "stimulation of translation initiation in response to stress" NARROW [] synonym: "up regulation of translation initiation in response to stress" EXACT [] synonym: "up-regulation of translation initiation in response to stress" EXACT [] synonym: "upregulation of translation initiation in response to stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043558 ! regulation of translational initiation in response to stress is_a: GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0032059 name: bleb namespace: cellular_component def: "A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291] subset: goslim_pir synonym: "plasma membrane bleb" EXACT [GOC:pr] xref: Wikipedia:Bleb_(cell_biology) is_a: GO:0120025 ! plasma membrane bounded cell projection [Term] id: GO:0032060 name: bleb assembly namespace: biological_process def: "The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses." [GOC:mah, GOC:mtg_apoptosis, http://en.wikipedia.org/wiki/Bleb_(cell_biology), PMID:12083798, PMID:16624291] synonym: "blebbing" BROAD [GOC:pr] synonym: "cell blebbing" EXACT [] synonym: "membrane blebbing" BROAD [GOC:pr] synonym: "plasma membrane bleb assembly" EXACT [GOC:pr] synonym: "plasma membrane blebbing" EXACT [GOC:pr] is_a: GO:0120031 ! plasma membrane bounded cell projection assembly [Term] id: GO:0032061 name: negative regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation in response to osmotic stress" EXACT [] synonym: "downregulation of translation in response to osmotic stress" EXACT [] synonym: "inhibition of translation in response to osmotic stress" NARROW [] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032062 name: positive regulation of translation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation in response to osmotic stress" NARROW [] synonym: "stimulation of translation in response to osmotic stress" NARROW [] synonym: "up regulation of translation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation in response to osmotic stress" EXACT [] synonym: "upregulation of translation in response to osmotic stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043557 ! regulation of translation in response to osmotic stress [Term] id: GO:0032063 name: negative regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "down regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "down-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "downregulation of translation initiation in response to osmotic stress" EXACT [] synonym: "inhibition of translation initiation in response to osmotic stress" NARROW [] is_a: GO:0032057 ! negative regulation of translational initiation in response to stress is_a: GO:0032061 ! negative regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032064 name: positive regulation of translational initiation in response to osmotic stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:mah] synonym: "activation of translation initiation in response to osmotic stress" NARROW [] synonym: "stimulation of translation initiation in response to osmotic stress" NARROW [] synonym: "up regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "up-regulation of translation initiation in response to osmotic stress" EXACT [] synonym: "upregulation of translation initiation in response to osmotic stress" EXACT [] is_a: GO:0032058 ! positive regulation of translational initiation in response to stress is_a: GO:0032062 ! positive regulation of translation in response to osmotic stress is_a: GO:0043561 ! regulation of translational initiation in response to osmotic stress [Term] id: GO:0032065 name: cortical protein anchoring namespace: biological_process def: "A process in which a protein or protein complex is maintained in a specific location in the cell cortex." [GOC:vw] synonym: "maintenance of protein location in cell cortex" EXACT [GOC:dph, GOC:tb] is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0032067 name: type IV site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated)." [PMID:12654995] synonym: "type IV restriction enzyme activity" EXACT [] is_a: GO:0015666 ! restriction endodeoxyribonuclease activity [Term] id: GO:0032068 name: type IV site-specific deoxyribonuclease complex namespace: cellular_component def: "A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation." [PMID:12654995] synonym: "type IV restriction enzyme complex" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1905347 ! endodeoxyribonuclease complex [Term] id: GO:0032069 name: regulation of nuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "nuclease regulator activity" RELATED [] is_a: GO:0019219 ! regulation of nucleobase-containing compound metabolic process is_a: GO:0051336 ! regulation of hydrolase activity is_a: GO:0060255 ! regulation of macromolecule metabolic process [Term] id: GO:0032070 name: regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease regulator" RELATED [] synonym: "DNase regulator" RELATED [] is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0051052 ! regulation of DNA metabolic process [Term] id: GO:0032071 name: regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "endodeoxyribonuclease regulator" RELATED [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity [Term] id: GO:0032072 name: regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity [Term] id: GO:0032073 name: negative regulation of restriction endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks." [GOC:mah] synonym: "down regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of restriction endodeoxyribonuclease activity" NARROW [] synonym: "restriction alleviation" NARROW [] synonym: "restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "restriction enzyme inhibitor" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity is_a: GO:0032078 ! negative regulation of endodeoxyribonuclease activity [Term] id: GO:0032074 name: negative regulation of nuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "down regulation of nuclease activity" EXACT [] synonym: "down-regulation of nuclease activity" EXACT [] synonym: "downregulation of nuclease activity" EXACT [] synonym: "inhibition of nuclease activity" NARROW [] synonym: "nuclease inhibitor" RELATED [] is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0045934 ! negative regulation of nucleobase-containing compound metabolic process is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0032075 name: positive regulation of nuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids." [GOC:mah] synonym: "activation of nuclease activity" NARROW [] synonym: "nuclease activator" RELATED [] synonym: "stimulation of nuclease activity" NARROW [] synonym: "up regulation of nuclease activity" EXACT [] synonym: "up-regulation of nuclease activity" EXACT [] synonym: "upregulation of nuclease activity" EXACT [] is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0032069 ! regulation of nuclease activity is_a: GO:0045935 ! positive regulation of nucleobase-containing compound metabolic process is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0032076 name: negative regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "deoxyribonuclease inhibitor" RELATED [] synonym: "DNase inhibitor" RELATED [] synonym: "down regulation of deoxyribonuclease activity" EXACT [] synonym: "down-regulation of deoxyribonuclease activity" EXACT [] synonym: "downregulation of deoxyribonuclease activity" EXACT [] synonym: "inhibition of deoxyribonuclease activity" NARROW [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032074 ! negative regulation of nuclease activity is_a: GO:0051053 ! negative regulation of DNA metabolic process [Term] id: GO:0032077 name: positive regulation of deoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah] synonym: "activation of deoxyribonuclease activity" NARROW [] synonym: "deoxyribonuclease activator" RELATED [] synonym: "DNase activator" RELATED [] synonym: "stimulation of deoxyribonuclease activity" NARROW [] synonym: "up regulation of deoxyribonuclease activity" EXACT [] synonym: "up-regulation of deoxyribonuclease activity" EXACT [] synonym: "upregulation of deoxyribonuclease activity" EXACT [] is_a: GO:0032070 ! regulation of deoxyribonuclease activity is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0051054 ! positive regulation of DNA metabolic process [Term] id: GO:0032078 name: negative regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "down regulation of endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of endodeoxyribonuclease activity" EXACT [] synonym: "endodeoxyribonuclease inhibitor" RELATED [] synonym: "inhibition of endodeoxyribonuclease activity" NARROW [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032076 ! negative regulation of deoxyribonuclease activity [Term] id: GO:0032079 name: positive regulation of endodeoxyribonuclease activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah] synonym: "activation of endodeoxyribonuclease activity" NARROW [] synonym: "endodeoxyribonuclease activator" RELATED [] synonym: "stimulation of endodeoxyribonuclease activity" NARROW [] synonym: "up regulation of endodeoxyribonuclease activity" EXACT [] synonym: "up-regulation of endodeoxyribonuclease activity" EXACT [] synonym: "upregulation of endodeoxyribonuclease activity" EXACT [] is_a: GO:0032071 ! regulation of endodeoxyribonuclease activity is_a: GO:0032077 ! positive regulation of deoxyribonuclease activity [Term] id: GO:0032080 name: negative regulation of type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type I restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type I restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type I restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type I restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032084 ! regulation of type I site-specific deoxyribonuclease activity [Term] id: GO:0032081 name: negative regulation of type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type II restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type II restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type II restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type II restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032085 ! regulation of type II site-specific deoxyribonuclease activity [Term] id: GO:0032082 name: negative regulation of type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type III restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type III restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type III restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type III restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type III restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032086 ! regulation of type III site-specific deoxyribonuclease activity [Term] id: GO:0032083 name: negative regulation of type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that stops or reduces the rate of type IV restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "down-regulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "downregulation of type IV restriction endodeoxyribonuclease activity" EXACT [] synonym: "inhibition of type IV restriction endodeoxyribonuclease activity" NARROW [] synonym: "negative regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph, GOC:tb] synonym: "type IV restriction endodeoxyribonuclease inhibitor" RELATED [] synonym: "type IV restriction enzyme inhibitor" RELATED [] is_a: GO:0032073 ! negative regulation of restriction endodeoxyribonuclease activity is_a: GO:0032087 ! regulation of type IV site-specific deoxyribonuclease activity [Term] id: GO:0032084 name: regulation of type I site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type I restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type I restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type I restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032085 name: regulation of type II site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type II restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type II restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type II restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032086 name: regulation of type III site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity." [GOC:dph, GOC:mah] synonym: "regulation of type III restriction endoribonuclease activity" EXACT [GOC:dph] synonym: "type III restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type III restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032087 name: regulation of type IV site-specific deoxyribonuclease activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity." [GOC:mah] synonym: "regulation of type IV restriction endodeoxyribonuclease activity" EXACT [GOC:dph] synonym: "type IV restriction endodeoxyribonuclease regulator" RELATED [] synonym: "type IV restriction enzyme regulator" RELATED [] is_a: GO:0032072 ! regulation of restriction endodeoxyribonuclease activity [Term] id: GO:0032088 name: negative regulation of NF-kappaB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB." [GOC:dph, GOC:rl, GOC:tb] synonym: "inhibition of NF-kappaB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "NF-kappaB inhibitor" RELATED [] is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity [Term] id: GO:0032089 name: NACHT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs." [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032090 name: Pyrin domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain." [GOC:rl] synonym: "DAPIN domain binding" EXACT [] synonym: "PAAD domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032091 name: negative regulation of protein binding namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein binding." [GOC:mah] synonym: "down regulation of protein binding" EXACT [] synonym: "down-regulation of protein binding" EXACT [] synonym: "downregulation of protein binding" EXACT [] synonym: "inhibition of protein binding" NARROW [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051100 ! negative regulation of binding [Term] id: GO:0032092 name: positive regulation of protein binding namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein binding." [GOC:mah] synonym: "activation of protein binding" NARROW [] synonym: "stimulation of protein binding" NARROW [] synonym: "up regulation of protein binding" EXACT [] synonym: "up-regulation of protein binding" EXACT [] synonym: "upregulation of protein binding" EXACT [] is_a: GO:0043393 ! regulation of protein binding is_a: GO:0051099 ! positive regulation of binding [Term] id: GO:0032093 name: SAM domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes." [GOC:mcc, PMID:16337230] synonym: "Sterile Alpha Motif domain binding" EXACT [] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032094 name: response to food namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat." [GOC:add, ISBN:0721601464] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical [Term] id: GO:0032095 name: regulation of response to food namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to a food stimulus." [GOC:add] is_a: GO:0032107 ! regulation of response to nutrient levels relationship: regulates GO:0032094 ! response to food [Term] id: GO:0032096 name: negative regulation of response to food namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus." [GOC:add] synonym: "down regulation of response to food" EXACT [] synonym: "down-regulation of response to food" EXACT [] synonym: "downregulation of response to food" EXACT [] synonym: "inhibition of response to food" NARROW [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032108 ! negative regulation of response to nutrient levels relationship: negatively_regulates GO:0032094 ! response to food [Term] id: GO:0032097 name: positive regulation of response to food namespace: biological_process def: "Any process that activates, maintains, or increases the rate of a response to a food stimulus." [GOC:add] synonym: "activation of response to food" NARROW [] synonym: "stimulation of response to food" NARROW [] synonym: "up regulation of response to food" EXACT [] synonym: "up-regulation of response to food" EXACT [] synonym: "upregulation of response to food" EXACT [] is_a: GO:0032095 ! regulation of response to food is_a: GO:0032109 ! positive regulation of response to nutrient levels relationship: positively_regulates GO:0032094 ! response to food [Term] id: GO:0032098 name: regulation of appetite namespace: biological_process def: "Any process which modulates appetite, the desire or physical craving for food." [GOC:add] synonym: "regulation of hunger" RELATED [] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0031667 ! response to nutrient levels [Term] id: GO:0032099 name: negative regulation of appetite namespace: biological_process def: "Any process that reduces appetite." [GOC:add] synonym: "appetite suppression" RELATED [] synonym: "down regulation of appetite" EXACT [] synonym: "down-regulation of appetite" EXACT [] synonym: "downregulation of appetite" EXACT [] synonym: "inhibition of appetite" NARROW [] synonym: "negative regulation of hunger" RELATED [] is_a: GO:0032096 ! negative regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032100 name: positive regulation of appetite namespace: biological_process def: "Any process that increases appetite." [GOC:add] synonym: "activation of appetite" NARROW [] synonym: "appetite stimulation" RELATED [] synonym: "positive regulation of hunger" RELATED [] synonym: "stimulation of appetite" NARROW [] synonym: "up regulation of appetite" EXACT [] synonym: "up-regulation of appetite" EXACT [] synonym: "upregulation of appetite" EXACT [] is_a: GO:0032097 ! positive regulation of response to food is_a: GO:0032098 ! regulation of appetite [Term] id: GO:0032101 name: regulation of response to external stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate is_a: GO:0048583 ! regulation of response to stimulus relationship: regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032102 name: negative regulation of response to external stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "down regulation of response to external stimulus" EXACT [] synonym: "down-regulation of response to external stimulus" EXACT [] synonym: "downregulation of response to external stimulus" EXACT [] synonym: "inhibition of response to external stimulus" NARROW [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048585 ! negative regulation of response to stimulus relationship: negatively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032103 name: positive regulation of response to external stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an external stimulus." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_manually_annotate synonym: "activation of response to external stimulus" NARROW [] synonym: "stimulation of response to external stimulus" NARROW [] synonym: "up regulation of response to external stimulus" EXACT [] synonym: "up-regulation of response to external stimulus" EXACT [] synonym: "upregulation of response to external stimulus" EXACT [] is_a: GO:0032101 ! regulation of response to external stimulus is_a: GO:0048584 ! positive regulation of response to stimulus relationship: positively_regulates GO:0009605 ! response to external stimulus [Term] id: GO:0032104 name: regulation of response to extracellular stimulus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] is_a: GO:0032101 ! regulation of response to external stimulus relationship: regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032105 name: negative regulation of response to extracellular stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus." [GOC:mah] synonym: "down regulation of response to extracellular stimulus" EXACT [] synonym: "down-regulation of response to extracellular stimulus" EXACT [] synonym: "downregulation of response to extracellular stimulus" EXACT [] synonym: "inhibition of response to extracellular stimulus" NARROW [] is_a: GO:0032102 ! negative regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: negatively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032106 name: positive regulation of response to extracellular stimulus namespace: biological_process def: "Any process that activates, maintains or increases the rate of a response to an extracellular stimulus." [GOC:mah] synonym: "activation of response to extracellular stimulus" NARROW [] synonym: "stimulation of response to extracellular stimulus" NARROW [] synonym: "up regulation of response to extracellular stimulus" EXACT [] synonym: "up-regulation of response to extracellular stimulus" EXACT [] synonym: "upregulation of response to extracellular stimulus" EXACT [] is_a: GO:0032103 ! positive regulation of response to external stimulus is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: positively_regulates GO:0009991 ! response to extracellular stimulus [Term] id: GO:0032107 name: regulation of response to nutrient levels namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a response to nutrient levels." [GOC:mah] is_a: GO:0032104 ! regulation of response to extracellular stimulus relationship: regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032108 name: negative regulation of response to nutrient levels namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "down regulation of response to nutrient levels" EXACT [] synonym: "down-regulation of response to nutrient levels" EXACT [] synonym: "downregulation of response to nutrient levels" EXACT [] synonym: "inhibition of response to nutrient levels" NARROW [] is_a: GO:0032105 ! negative regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels relationship: negatively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032109 name: positive regulation of response to nutrient levels namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a response to nutrient levels." [GOC:mah] synonym: "activation of response to nutrient levels" NARROW [] synonym: "stimulation of response to nutrient levels" NARROW [] synonym: "up regulation of response to nutrient levels" EXACT [] synonym: "up-regulation of response to nutrient levels" EXACT [] synonym: "upregulation of response to nutrient levels" EXACT [] is_a: GO:0032106 ! positive regulation of response to extracellular stimulus is_a: GO:0032107 ! regulation of response to nutrient levels relationship: positively_regulates GO:0031667 ! response to nutrient levels [Term] id: GO:0032110 name: regulation of protein histidine kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] is_a: GO:0045859 ! regulation of protein kinase activity [Term] id: GO:0032111 name: activation of protein histidine kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein histidine kinase." [GOC:mah] synonym: "protein histidine kinase activator" RELATED [] is_a: GO:0010864 ! positive regulation of protein histidine kinase activity is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032112 name: negative regulation of protein histidine kinase activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity." [GOC:mah] synonym: "down regulation of protein histidine kinase activity" EXACT [] synonym: "down-regulation of protein histidine kinase activity" EXACT [] synonym: "downregulation of protein histidine kinase activity" EXACT [] synonym: "inhibition of protein histidine kinase activity" NARROW [] synonym: "protein histidine kinase inhibitor" RELATED [] is_a: GO:0006469 ! negative regulation of protein kinase activity is_a: GO:0032110 ! regulation of protein histidine kinase activity [Term] id: GO:0032113 name: regulation of carbohydrate phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate." [GOC:mah] is_a: GO:0010921 ! regulation of phosphatase activity [Term] id: GO:0032114 name: regulation of glucose-6-phosphatase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [GOC:kp] is_a: GO:0032113 ! regulation of carbohydrate phosphatase activity [Term] id: GO:0032115 name: sorbose reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction." [EC:1.1.1.289, RHEA:14609] synonym: "D-glucitol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.289] synonym: "Sou1p" RELATED [EC:1.1.1.289] xref: EC:1.1.1.289 xref: KEGG:R07346 xref: MetaCyc:1.1.1.289-RXN xref: RHEA:14609 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032116 name: SMC loading complex namespace: cellular_component def: "A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved." [GOC:curators, GOC:vw, PMID:10882066] synonym: "chromatin loading complex" RELATED [GOC:curators] synonym: "cohesin loading complex" NARROW [GOC:curators] synonym: "SCC2/SCC4 loading complex" NARROW [GOC:curators] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032117 name: horsetail-astral microtubule array namespace: cellular_component def: "An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement." [GOC:mah, PMID:16111942] synonym: "HAA" EXACT [] is_a: GO:0005818 ! aster is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030981 ! cortical microtubule cytoskeleton [Term] id: GO:0032118 name: horsetail-astral microtubule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis." [GOC:mah] synonym: "horsetail-astral microtubule array organization" EXACT [] synonym: "horsetail-astral microtubule organisation" EXACT [GOC:mah] synonym: "horsetail-astral microtubule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0030989 ! dynein-driven meiotic oscillatory nuclear movement [Term] id: GO:0032119 name: sequestering of zinc ion namespace: biological_process def: "The process of binding or confining zinc ions such that they are separated from other components of a biological system." [GOC:mah] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0006882 ! cellular zinc ion homeostasis [Term] id: GO:0032120 name: ascospore-type prospore membrane assembly namespace: biological_process def: "The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed." [GOC:clt] synonym: "forespore membrane biosynthesis" EXACT [] synonym: "forespore membrane formation" EXACT [] synonym: "FSM assembly" EXACT [] synonym: "FSM biosynthesis" EXACT [] synonym: "FSM formation" EXACT [] is_a: GO:0003006 ! developmental process involved in reproduction is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0071709 ! membrane assembly is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0031321 ! ascospore-type prospore assembly [Term] id: GO:0032121 name: meiotic attachment of telomeric heterochromatin to spindle pole body namespace: biological_process def: "The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation." [GOC:pr, PMID:16615890] synonym: "attachment of telomeres to spindle pole body" BROAD [] synonym: "attachment of telomeric chromatin to spindle pole body" BROAD [] is_a: GO:0007017 ! microtubule-based process is_a: GO:1903046 ! meiotic cell cycle process relationship: part_of GO:0045141 ! meiotic telomere clustering [Term] id: GO:0032122 name: oral apparatus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans." [PMID:10503189, PMID:6414830] synonym: "oral apparatus morphogenesis" RELATED [] synonym: "oral apparatus organisation" EXACT [GOC:mah] synonym: "oral apparatus organization and biogenesis" RELATED [GOC:mah] synonym: "stomatogenesis" RELATED [] is_a: GO:0016043 ! cellular component organization [Term] id: GO:0032123 name: deep fiber namespace: cellular_component def: "Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm." [PMID:10503189] synonym: "deep fibre" EXACT [] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0031912 ! oral apparatus [Term] id: GO:0032124 name: macronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "macronuclear organization" EXACT [] synonym: "macronuclear organization and biogenesis" RELATED [GOC:mah] synonym: "macronucleus organisation" EXACT [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032125 name: micronucleus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus." [GOC:dph, GOC:jl, GOC:mah, PMID:10503190] synonym: "micronuclear organization" EXACT [] synonym: "micronuclear organization and biogenesis" RELATED [GOC:mah] synonym: "micronucleus organisation" EXACT [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0032126 name: eisosome namespace: cellular_component def: "A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization." [GOC:al, GOC:vw, PMID:16496001, PMID:22368779] xref: Wikipedia:Eisosome is_a: GO:0044464 ! cell part [Term] id: GO:0032127 name: dense core granule membrane namespace: cellular_component def: "The lipid bilayer surrounding a dense core granule." [GOC:mah] synonym: "dense core vesicle membrane" EXACT [GOC:kmv] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0031045 ! dense core granule [Term] id: GO:0032128 name: flocculation via extracellular polymer namespace: biological_process def: "Non-sexual aggregation of single-celled organisms mediated by polymers (polysaccharides, proteins, and/or nucleic acids) secreted into the extracellular environment." [DOI:10.1007/s002530051351, GOC:mah, PMID:14538073] synonym: "flocculation via EBF" EXACT [] synonym: "flocculation via extracellular biopolymeric flocculants" EXACT [] is_a: GO:0000128 ! flocculation [Term] id: GO:0032129 name: histone deacetylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein." [EC:3.5.1.17, RHEA:24548] is_a: GO:0004407 ! histone deacetylase activity [Term] id: GO:0032130 name: medial membrane band assembly namespace: biological_process def: "The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring." [PMID:15517003] synonym: "medial membrane band formation" RELATED [gOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:1902410 ! mitotic cytokinetic process [Term] id: GO:0032131 name: alkylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with alkylated residues in DNA." [GOC:mah] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032132 name: O6-alkylguanine-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with O6-alkylguanine adducts in DNA." [GOC:mah, PMID:16679453] is_a: GO:0032131 ! alkylated DNA binding [Term] id: GO:0032133 name: chromosome passenger complex namespace: cellular_component def: "A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin." [GOC:vw, PMID:16824200, PMID:19570910] synonym: "chromosomal passenger complex" EXACT [GOC:mcc] synonym: "CPC" BROAD [GOC:mah] synonym: "CPC complex" EXACT [GOC:vw] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0032135 name: DNA insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing insertions or deletions." [GOC:vk] synonym: "DNA insertion binding" NARROW [] synonym: "insertion binding" EXACT [] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032136 name: adenine/cytosine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing an A/C mispair." [GOC:vk] synonym: "A/C mispair binding" EXACT [GOC:bf] synonym: "C/A mispair binding" EXACT [GOC:bf] synonym: "cytosine/adenine mispair binding" RELATED [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032137 name: guanine/thymine mispair binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a G/T mispair." [GOC:vk] synonym: "G/T mispair binding" EXACT [GOC:bf] synonym: "T/G mispair binding" EXACT [GOC:bf] synonym: "thymine/guanine mispair binding" EXACT [GOC:bf] is_a: GO:0030983 ! mismatched DNA binding [Term] id: GO:0032138 name: single base insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single base insertion or deletion." [GOC:vk] synonym: "single base insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032139 name: dinucleotide insertion or deletion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide insertion or deletion." [GOC:vk] synonym: "dinucleotide insertion binding" NARROW [] is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0032140 name: single adenine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single adenine insertion or a deletion that results in an unpaired adenine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032141 name: single cytosine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single cytosine insertion or a deletion that results in an unpaired cytosine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032142 name: single guanine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single guanine insertion or a deletion that results in an unpaired guanine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032143 name: single thymine insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a single thymine insertion or a deletion that results in an unpaired thymine." [GOC:mah, GOC:vk] is_a: GO:0032138 ! single base insertion or deletion binding [Term] id: GO:0032144 name: 4-aminobutyrate transaminase complex namespace: cellular_component def: "A homodimeric protein complex that possesses 4-aminobutyrate transaminase activity." [GOC:mah, PMID:15528998] synonym: "ABAT complex" EXACT [] synonym: "GABA transaminase complex" EXACT [] synonym: "GABA-T complex" EXACT [] is_a: GO:0044424 ! intracellular part is_a: GO:1990234 ! transferase complex [Term] id: GO:0032145 name: succinate-semialdehyde dehydrogenase binding namespace: molecular_function def: "Interacting selectively and non-covalently with succinate-semialdehyde dehydrogenase." [GOC:mah] synonym: "succinic semialdehyde dehydrogenase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032147 name: activation of protein kinase activity namespace: biological_process def: "Any process that initiates the activity of an inactive protein kinase." [GOC:mah] synonym: "protein kinase activation" RELATED [] is_a: GO:0045860 ! positive regulation of protein kinase activity [Term] id: GO:0032148 name: activation of protein kinase B activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme protein kinase B." [GOC:pg] synonym: "protein kinase B activation" EXACT [] is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0032149 name: response to rhamnose namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus." [GOC:mlg] synonym: "response to L-rhamnose stimulus" NARROW [] synonym: "response to rhamnose stimulus" EXACT [GOC:dos] is_a: GO:0009746 ! response to hexose [Term] id: GO:0032150 name: ubiquinone biosynthetic process from chorismate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0032151 name: mitotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during mitotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032152 name: meiotic septin complex namespace: cellular_component def: "A heterooligomeric septin complex that acts during meiotic cell division." [GOC:krc, PMID:16009555] is_a: GO:0031105 ! septin complex [Term] id: GO:0032153 name: cell division site namespace: cellular_component def: "The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles." [GOC:bf, GOC:imk, GOC:krc, GOC:ns, PMID:12101122, PMID:15380095, PMID:16983191, PMID:18165305] comment: Note that this term refers to the future site of division in a cell that has not yet divided. subset: goslim_pir synonym: "cell division plane" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0032154 name: cleavage furrow namespace: cellular_component def: "The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm." [GOC:vw, ISBN:0805319409] comment: While the term 'cleavage furrow' was initially associated with animal cells, such a structure occurs in many other types of cells, including unicellular protists. xref: Wikipedia:Cleavage_furrow is_a: GO:0032155 ! cell division site part is_a: GO:0098590 ! plasma membrane region [Term] id: GO:0032155 name: cell division site part namespace: cellular_component def: "Any constituent part of the cell division plane, the eventual plane of cell division in a dividing cell." [GOC:mah] comment: Note that this term is in the subset of terms that should not be used for direct gene product annotation. Instead, select a child term or, if no appropriate child term exists, please request a new term. Direct annotations to this term may be amended during annotation QC. subset: gocheck_do_not_annotate synonym: "cell division plane part" EXACT [] is_a: GO:0044464 ! cell part relationship: part_of GO:0032153 ! cell division site [Term] id: GO:0032156 name: septin cytoskeleton namespace: cellular_component def: "The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes." [GOC:mah] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0032157 name: prospore contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis." [GOC:krc, PMID:16009555] synonym: "actomyosin ring" RELATED [] synonym: "cytokinetic ring" RELATED [] synonym: "meiotic contractile ring" RELATED [] is_a: GO:0110086 ! meiotic actomyosin contractile ring relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032158 name: septin band namespace: cellular_component def: "A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, PMID:16151244] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032159 name: septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032160 name: septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans." [GOC:krc, PMID:16151244] synonym: "septin bar" RELATED [] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032161 name: cleavage apparatus septin structure namespace: cellular_component def: "Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis." [GOC:krc, PMID:12101122, PMID:15774761, PMID:16009555] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0032156 ! septin cytoskeleton [Term] id: GO:0032162 name: mating projection septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection)." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032163 name: hyphal septin band namespace: cellular_component def: "A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0032158 ! septin band [Term] id: GO:0032164 name: hyphal septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap [Term] id: GO:0032165 name: prospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032166 name: chlamydospore septin filament array namespace: cellular_component def: "Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation." [GOC:krc, PMID:16151244] is_a: GO:0032160 ! septin filament array [Term] id: GO:0032167 name: obsolete septin patch namespace: cellular_component def: "OBSOLETE. An amorphous-appearing accumulation of septin proteins at the future site of cytokinesis." [PMID:16009555] comment: This term was made obsolete because it was added in error; it does not refer to a normal subcellular structure. synonym: "septin patch" EXACT [] is_obsolete: true [Term] id: GO:0032168 name: hyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032169 name: prospore septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0032170 name: pseudohyphal septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring [Term] id: GO:0032171 name: germ tube septin cap namespace: cellular_component def: "A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol." [GOC:krc, PMID:16151244] is_a: GO:0032159 ! septin cap relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032172 name: germ tube septin ring namespace: cellular_component def: "A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins." [GOC:krc, PMID:16151244] is_a: GO:0005940 ! septin ring relationship: part_of GO:0032179 ! germ tube [Term] id: GO:0032173 name: septin collar namespace: cellular_component def: "A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032174 name: cellular bud neck septin collar namespace: cellular_component def: "A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032173 ! septin collar [Term] id: GO:0032175 name: mating projection septin ring namespace: cellular_component def: "A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip." [GOC:krc, GOC:mah, PMID:16151244] is_a: GO:0005940 ! septin ring is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0032176 name: split septin rings namespace: cellular_component def: "A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well." [GOC:krc, PMID:16009555, PMID:16151244] is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part [Term] id: GO:0032177 name: cellular bud neck split septin rings namespace: cellular_component def: "Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0032161 ! cleavage apparatus septin structure is_a: GO:0032176 ! split septin rings [Term] id: GO:0032178 name: medial membrane band namespace: cellular_component def: "A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum." [PMID:15517003] synonym: "sterol-rich membrane band" RELATED [] is_a: GO:0032155 ! cell division site part is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0032179 name: germ tube namespace: cellular_component def: "The slender tubular outgrowth first produced by most spores in germination." [ISBN:0877799148] subset: goslim_pir xref: Wikipedia:Germ_tube is_a: GO:0044464 ! cell part [Term] id: GO:0032180 name: ubiquinone biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032181 name: dinucleotide repeat insertion binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats." [GOC:mah, GOC:vk] is_a: GO:0032139 ! dinucleotide insertion or deletion binding [Term] id: GO:0032182 name: ubiquitin-like protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a small conjugating protein such as ubiquitin or a ubiquitin-like protein." [GOC:mah] subset: goslim_chembl subset: goslim_generic subset: goslim_yeast synonym: "small conjugating protein binding" EXACT [GOC:dph] is_a: GO:0005515 ! protein binding [Term] id: GO:0032183 name: SUMO binding namespace: molecular_function def: "Interacting selectively and non-covalently with the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 binding" RELATED [] synonym: "Smt3 monomer binding" NARROW [] is_a: GO:0032182 ! ubiquitin-like protein binding [Term] id: GO:0032184 name: SUMO polymer binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polymer of the small ubiquitin-like protein SUMO." [GOC:mah] synonym: "Smt3 polymer binding" EXACT [] is_a: GO:0032183 ! SUMO binding [Term] id: GO:0032185 name: septin cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins." [GOC:dph, GOC:jl, GOC:mah] synonym: "septin cytoskeleton organisation" EXACT [GOC:mah] synonym: "septin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007010 ! cytoskeleton organization [Term] id: GO:0032186 name: cellular bud neck septin ring organization namespace: biological_process def: "Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck." [GOC:mah] synonym: "cellular bud neck septin ring organisation" EXACT [GOC:mah] is_a: GO:0031106 ! septin ring organization is_a: GO:1903047 ! mitotic cell cycle process relationship: part_of GO:0000281 ! mitotic cytokinesis relationship: part_of GO:0007105 ! cytokinesis, site selection [Term] id: GO:0032187 name: actomyosin contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:mah] synonym: "contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] is_a: GO:0036214 ! contractile ring localization [Term] id: GO:0032188 name: establishment of actomyosin contractile ring localization namespace: biological_process def: "The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis." [GOC:mah] synonym: "actomyosin ring positioning" RELATED [GOC:mah] synonym: "contractile ring positioning" BROAD [GOC:mah] synonym: "cytokinesis site selection by contractile ring positioning" EXACT [GOC:mah, GOC:vw] synonym: "establishment of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "establishment of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "establishment of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! actomyosin contractile ring localization relationship: part_of GO:0007105 ! cytokinesis, site selection [Term] id: GO:0032189 name: maintenance of actomyosin contractile ring localization namespace: biological_process def: "Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere." [GOC:mah] synonym: "cytokinetic ring anchoring" RELATED [] synonym: "maintenance of contractile ring localisation involved in cell cycle cytokinesis" EXACT [GOC:mah] synonym: "maintenance of contractile ring localization involved in cell cycle cytokinesis" EXACT [GOC:mah, GOC:vw] synonym: "maintenance of contractile ring localization involved in cytokinesis during cell cycle" RELATED [GOC:dph, GOC:tb] is_a: GO:0032187 ! actomyosin contractile ring localization relationship: part_of GO:0031566 ! actomyosin contractile ring maintenance [Term] id: GO:0032190 name: acrosin binding namespace: molecular_function alt_id: GO:0032191 alt_id: GO:0032192 def: "Interacting selectively and non-covalently with acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities." [GOC:mah, PMID:12398221] synonym: "acrosin heavy chain binding" NARROW [] synonym: "acrosin light chain binding" NARROW [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0032193 name: ubiquinone biosynthetic process via 2-polyprenylphenol namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032194 name: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate." [GOC:mah, PMID:11583838] is_a: GO:0006744 ! ubiquinone biosynthetic process [Term] id: GO:0032195 name: post-lysosomal vacuole namespace: cellular_component def: "A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis." [GOC:pf, PMID:9276759, PMID:9394012] synonym: "post-lysosome" EXACT [GOC:dph] is_a: GO:0005773 ! vacuole is_a: GO:0030139 ! endocytic vesicle [Term] id: GO:0032196 name: transposition namespace: biological_process def: "Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites." [GOC:jp, ISBN:1555812090] subset: goslim_aspergillus subset: goslim_candida subset: goslim_chembl subset: goslim_generic subset: goslim_pir subset: goslim_yeast xref: Wikipedia:Transposon is_a: GO:0009987 ! cellular process [Term] id: GO:0032197 name: transposition, RNA-mediated namespace: biological_process alt_id: GO:0006319 alt_id: GO:0006320 alt_id: GO:0006321 alt_id: GO:0006322 def: "Any process involved in a type of transpositional recombination which occurs via an RNA intermediate." [GOC:jp, ISBN:1555812090] synonym: "Class I transposition" EXACT [] synonym: "retrotransposition" EXACT [] synonym: "retrotransposon transposition" EXACT [] synonym: "RNA-mediated transposition" EXACT [GOC:dph, GOC:tb] synonym: "Tf transposition" NARROW [] synonym: "Ty element transposition" NARROW [] synonym: "Ty1 element transposition" NARROW [] synonym: "Ty2 element transposition" NARROW [] synonym: "Ty3 element transposition" NARROW [] xref: Wikipedia:Transposon##Class_I\:_Retrotransposons is_a: GO:0032196 ! transposition [Term] id: GO:0032198 name: MITE transposition namespace: biological_process def: "Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs)." [GOC:jp, ISBN:1555812090] synonym: "Class III transposition" EXACT [] is_a: GO:0032196 ! transposition [Term] id: GO:0032199 name: reverse transcription involved in RNA-mediated transposition namespace: biological_process def: "The synthesis of DNA from an RNA transposon intermediate." [GOC:jp, GOC:txnOH, ISBN:1555812090] synonym: "reverse transcription during retrotransposition" EXACT [] is_a: GO:0001171 ! reverse transcription relationship: part_of GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0032200 name: telomere organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pombe subset: goslim_yeast synonym: "chromosome organization, telomeric" EXACT [] synonym: "organization of chromosome, telomeric region" EXACT [] synonym: "telomere organisation" EXACT [GOC:mah] synonym: "telomere organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0032201 name: telomere maintenance via semi-conservative replication namespace: biological_process def: "The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication." [GOC:BHF, GOC:BHF_telomere, GOC:rl, GOC:vw, PMID:16598261] synonym: "equal telomere replication" RELATED [] synonym: "telomeric fork progression" NARROW [] synonym: "telomeric replication fork progression" NARROW [] is_a: GO:0000723 ! telomere maintenance is_a: GO:0019725 ! cellular homeostasis is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0033260 ! nuclear DNA replication [Term] id: GO:0032202 name: telomere assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins." [GOC:mah, GOC:ns, PMID:11902675, PMID:8622671] synonym: "telomere formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032200 ! telomere organization [Term] id: GO:0032203 name: telomere formation via telomerase namespace: biological_process def: "A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme." [GOC:cjm, GOC:ns, PMID:11902675, PMID:8622671] is_a: GO:0032202 ! telomere assembly [Term] id: GO:0032204 name: regulation of telomere maintenance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0065008 ! regulation of biological quality relationship: regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032205 name: negative regulation of telomere maintenance namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance" EXACT [] synonym: "down-regulation of telomere maintenance" EXACT [] synonym: "downregulation of telomere maintenance" EXACT [] synonym: "inhibition of telomere maintenance" NARROW [] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2001251 ! negative regulation of chromosome organization relationship: negatively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032206 name: positive regulation of telomere maintenance namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance" NARROW [] synonym: "stimulation of telomere maintenance" NARROW [] synonym: "up regulation of telomere maintenance" EXACT [] synonym: "up-regulation of telomere maintenance" EXACT [] synonym: "upregulation of telomere maintenance" EXACT [] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2001252 ! positive regulation of chromosome organization relationship: positively_regulates GO:0000723 ! telomere maintenance [Term] id: GO:0032207 name: regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] is_a: GO:0000019 ! regulation of mitotic recombination is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0072695 ! regulation of DNA recombination at telomere relationship: regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032208 name: negative regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "down regulation of telomere maintenance via recombination" EXACT [] synonym: "down-regulation of telomere maintenance via recombination" EXACT [] synonym: "downregulation of telomere maintenance via recombination" EXACT [] synonym: "inhibition of telomere maintenance via recombination" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045950 ! negative regulation of mitotic recombination is_a: GO:0048239 ! negative regulation of DNA recombination at telomere relationship: negatively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032209 name: positive regulation of telomere maintenance via recombination namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length." [GOC:mah] synonym: "activation of telomere maintenance via recombination" NARROW [] synonym: "stimulation of telomere maintenance via recombination" NARROW [] synonym: "up regulation of telomere maintenance via recombination" EXACT [] synonym: "up-regulation of telomere maintenance via recombination" EXACT [] synonym: "upregulation of telomere maintenance via recombination" EXACT [] is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032207 ! regulation of telomere maintenance via recombination is_a: GO:0045951 ! positive regulation of mitotic recombination is_a: GO:0072696 ! positive regulation of DNA recombination at telomere relationship: positively_regulates GO:0000722 ! telomere maintenance via recombination [Term] id: GO:0032210 name: regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] is_a: GO:1904356 ! regulation of telomere maintenance via telomere lengthening is_a: GO:2000278 ! regulation of DNA biosynthetic process relationship: regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032211 name: negative regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "down regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "down-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "downregulation of telomere maintenance via telomerase activity" EXACT [] synonym: "inhibition of telomere maintenance via telomerase" NARROW [] is_a: GO:0032210 ! regulation of telomere maintenance via telomerase is_a: GO:1904357 ! negative regulation of telomere maintenance via telomere lengthening is_a: GO:2000279 ! negative regulation of DNA biosynthetic process relationship: negatively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032212 name: positive regulation of telomere maintenance via telomerase namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase." [GOC:mah] synonym: "activation of telomere maintenance via telomerase" NARROW [] synonym: "stimulation of telomere maintenance via telomerase" NARROW [] synonym: "up regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "up-regulation of telomere maintenance via telomerase activity" EXACT [] synonym: "upregulation of telomere maintenance via telomerase activity" EXACT [] is_a: GO:0032210 ! regulation of telomere maintenance via telomerase is_a: GO:1904358 ! positive regulation of telomere maintenance via telomere lengthening is_a: GO:2000573 ! positive regulation of DNA biosynthetic process relationship: positively_regulates GO:0007004 ! telomere maintenance via telomerase [Term] id: GO:0032213 name: regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] is_a: GO:0032204 ! regulation of telomere maintenance is_a: GO:0033262 ! regulation of nuclear cell cycle DNA replication relationship: regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032214 name: negative regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "down regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "down-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "downregulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "inhibition of telomere maintenance via semi-conservative replication" NARROW [] is_a: GO:0032205 ! negative regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication is_a: GO:1902576 ! negative regulation of nuclear cell cycle DNA replication relationship: negatively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032215 name: positive regulation of telomere maintenance via semi-conservative replication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA." [GOC:mah] synonym: "activation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "stimulation of telomere maintenance via semi-conservative replication" NARROW [] synonym: "up regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "up-regulation of telomere maintenance via semi-conservative replication" EXACT [] synonym: "upregulation of telomere maintenance via semi-conservative replication" EXACT [] is_a: GO:0010571 ! positive regulation of nuclear cell cycle DNA replication is_a: GO:0032206 ! positive regulation of telomere maintenance is_a: GO:0032213 ! regulation of telomere maintenance via semi-conservative replication relationship: positively_regulates GO:0032201 ! telomere maintenance via semi-conservative replication [Term] id: GO:0032216 name: glucosaminyl-phosphotidylinositol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: glucosaminyl-phosphotidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phosphotidylinositol + CoA." [Reactome:R-HSA-162683] synonym: "GPI-inositol acyltransferase" RELATED [] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032217 name: riboflavin transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] synonym: "riboflavin transporter activity" RELATED [] xref: reactome:R-HSA-3165230 "SLC52A1,2,3 transport RIB from extracellular region to cytosol" is_a: GO:0008514 ! organic anion transmembrane transporter activity is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0090482 ! vitamin transmembrane transporter activity [Term] id: GO:0032218 name: riboflavin transport namespace: biological_process def: "The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins." [GOC:rn, PMID:16204239] is_a: GO:0015711 ! organic anion transport is_a: GO:0015893 ! drug transport is_a: GO:0051180 ! vitamin transport is_a: GO:0071705 ! nitrogen compound transport [Term] id: GO:0032219 name: cell wall macromolecule catabolic process involved in cytogamy namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy." [GOC:mah] synonym: "cell wall macromolecule catabolic process during cytogamy" RELATED [GOC:dph, GOC:tb] is_a: GO:0016998 ! cell wall macromolecule catabolic process is_a: GO:0022414 ! reproductive process relationship: part_of GO:0000755 ! cytogamy [Term] id: GO:0032220 name: plasma membrane fusion involved in cytogamy namespace: biological_process alt_id: GO:0070872 def: "The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy." [GOC:mah, PMID:29134248] comment: Merged terms see https://github.com/geneontology/go-ontology/issues/16258 synonym: "plasma membrane fusion during cytogamy" RELATED [GOC:dph, GOC:tb] synonym: "plasma membrane organization involved in conjugation with cellular fusion" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0000755 ! cytogamy [Term] id: GO:0032221 name: Rpd3S complex namespace: cellular_component alt_id: GO:0000509 def: "A eukaryotically conserved histone deacetylase complex which deacetylates histones preferentially in promoter regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species)." [GOC:vw, PMID:12773392, PMID:17450151] synonym: "Clr6 histone deacetylase complex II'" EXACT [GOC:vw] synonym: "Clr6S complex" EXACT [PMID:19040720] synonym: "Rpd3C(S)" EXACT [] is_a: GO:0070822 ! Sin3-type complex [Term] id: GO:0032222 name: regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission relationship: regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032223 name: negative regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "down regulation of synaptic transmission, cholinergic" EXACT [] synonym: "down-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "downregulation of synaptic transmission, cholinergic" EXACT [] synonym: "inhibition of synaptic transmission, cholinergic" NARROW [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032224 name: positive regulation of synaptic transmission, cholinergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:mah] synonym: "activation of synaptic transmission, cholinergic" NARROW [] synonym: "stimulation of synaptic transmission, cholinergic" NARROW [] synonym: "up regulation of synaptic transmission, cholinergic" EXACT [] synonym: "up-regulation of synaptic transmission, cholinergic" EXACT [] synonym: "upregulation of synaptic transmission, cholinergic" EXACT [] is_a: GO:0032222 ! regulation of synaptic transmission, cholinergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0032225 name: regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission relationship: regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032226 name: positive regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "activation of synaptic transmission, dopaminergic" NARROW [] synonym: "stimulation of synaptic transmission, dopaminergic" NARROW [] synonym: "up regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "up-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "upregulation of synaptic transmission, dopaminergic" EXACT [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032227 name: negative regulation of synaptic transmission, dopaminergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:mah] synonym: "down regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "down-regulation of synaptic transmission, dopaminergic" EXACT [] synonym: "downregulation of synaptic transmission, dopaminergic" EXACT [] synonym: "inhibition of synaptic transmission, dopaminergic" NARROW [] is_a: GO:0032225 ! regulation of synaptic transmission, dopaminergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0001963 ! synaptic transmission, dopaminergic [Term] id: GO:0032228 name: regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] is_a: GO:0050804 ! modulation of chemical synaptic transmission relationship: regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032229 name: negative regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "down regulation of synaptic transmission, GABAergic" EXACT [] synonym: "down-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "downregulation of synaptic transmission, GABAergic" EXACT [] synonym: "inhibition of synaptic transmission, GABAergic" NARROW [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050805 ! negative regulation of synaptic transmission relationship: negatively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032230 name: positive regulation of synaptic transmission, GABAergic namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA)." [GOC:mah] synonym: "activation of synaptic transmission, GABAergic" NARROW [] synonym: "stimulation of synaptic transmission, GABAergic" NARROW [] synonym: "up regulation of synaptic transmission, GABAergic" EXACT [] synonym: "up-regulation of synaptic transmission, GABAergic" EXACT [] synonym: "upregulation of synaptic transmission, GABAergic" EXACT [] is_a: GO:0032228 ! regulation of synaptic transmission, GABAergic is_a: GO:0050806 ! positive regulation of synaptic transmission relationship: positively_regulates GO:0051932 ! synaptic transmission, GABAergic [Term] id: GO:0032231 name: regulation of actin filament bundle assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "regulation of actin cable assembly" EXACT [GOC:dph, GOC:tb] synonym: "regulation of actin filament bundle formation" RELATED [GOC:dph] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0110053 ! regulation of actin filament organization relationship: regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032232 name: negative regulation of actin filament bundle assembly namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "down regulation of actin filament bundle formation" EXACT [] synonym: "down-regulation of actin filament bundle formation" EXACT [] synonym: "downregulation of actin filament bundle formation" EXACT [] synonym: "inhibition of actin filament bundle formation" NARROW [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0051494 ! negative regulation of cytoskeleton organization is_a: GO:1902904 ! negative regulation of supramolecular fiber organization relationship: negatively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032233 name: positive regulation of actin filament bundle assembly namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles." [GOC:mah] synonym: "activation of actin filament bundle formation" NARROW [] synonym: "stimulation of actin filament bundle formation" NARROW [] synonym: "up regulation of actin filament bundle formation" EXACT [] synonym: "up-regulation of actin filament bundle formation" EXACT [] synonym: "upregulation of actin filament bundle formation" EXACT [] is_a: GO:0032231 ! regulation of actin filament bundle assembly is_a: GO:0044089 ! positive regulation of cellular component biogenesis is_a: GO:0051495 ! positive regulation of cytoskeleton organization is_a: GO:1902905 ! positive regulation of supramolecular fiber organization relationship: positively_regulates GO:0051017 ! actin filament bundle assembly [Term] id: GO:0032234 name: obsolete regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "regulation of store-operated calcium channel activity" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032235 name: obsolete negative regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "down regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "down-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "downregulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "inhibition of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "negative regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "negative regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "negative regulation of store-operated calcium channel activity" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032236 name: obsolete positive regulation of calcium ion transport via store-operated calcium channel activity namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the directed movement of calcium ions via a store-operated calcium channel." [GOC:bf, PMID:16582901] comment: This term was made obsolete because it is ill-defined: channel activities are part of ion transport processes, and not the other way round. synonym: "activation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "positive regulation of calcium ion transport via store-operated calcium channel activity" EXACT [] synonym: "positive regulation of calcium transport via store-operated calcium channel" EXACT [] synonym: "positive regulation of store-operated calcium channel activity" EXACT [] synonym: "stimulation of calcium ion transport via store-operated calcium channel" NARROW [] synonym: "up regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "up-regulation of calcium ion transport via store-operated calcium channel" EXACT [] synonym: "upregulation of calcium ion transport via store-operated calcium channel" EXACT [] is_obsolete: true consider: GO:0015279 [Term] id: GO:0032237 name: activation of store-operated calcium channel activity namespace: biological_process def: "A process that initiates the activity of an inactive store-operated calcium channel." [GOC:mah] is_a: GO:1901341 ! positive regulation of store-operated calcium channel activity [Term] id: GO:0032238 name: adenosine transport namespace: biological_process def: "The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0015858 ! nucleoside transport is_a: GO:0015893 ! drug transport [Term] id: GO:0032239 name: regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032240 name: negative regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "down-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "downregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "inhibition of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032241 name: positive regulation of nucleobase-containing compound transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" RELATED [GOC:dph, GOC:tb] synonym: "stimulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" NARROW [] synonym: "up regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "up-regulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] synonym: "upregulation of nucleobase, nucleoside, nucleotide and nucleic acid transport" EXACT [] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0015931 ! nucleobase-containing compound transport [Term] id: GO:0032242 name: regulation of nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032239 ! regulation of nucleobase-containing compound transport relationship: regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032243 name: negative regulation of nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of nucleoside transport" EXACT [] synonym: "down-regulation of nucleoside transport" EXACT [] synonym: "downregulation of nucleoside transport" EXACT [] synonym: "inhibition of nucleoside transport" NARROW [] is_a: GO:0032240 ! negative regulation of nucleobase-containing compound transport is_a: GO:0032242 ! regulation of nucleoside transport relationship: negatively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032244 name: positive regulation of nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of nucleoside transport" NARROW [] synonym: "stimulation of nucleoside transport" NARROW [] synonym: "up regulation of nucleoside transport" EXACT [] synonym: "up-regulation of nucleoside transport" EXACT [] synonym: "upregulation of nucleoside transport" EXACT [] is_a: GO:0032241 ! positive regulation of nucleobase-containing compound transport is_a: GO:0032242 ! regulation of nucleoside transport relationship: positively_regulates GO:0015858 ! nucleoside transport [Term] id: GO:0032245 name: regulation of purine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport [Term] id: GO:0032246 name: regulation of pyrimidine nucleoside transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032242 ! regulation of nucleoside transport relationship: regulates GO:0015864 ! pyrimidine nucleoside transport [Term] id: GO:0032247 name: negative regulation of purine nucleoside transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of purine nucleoside transport" EXACT [] synonym: "down-regulation of purine nucleoside transport" EXACT [] synonym: "downregulation of purine nucleoside transport" EXACT [] synonym: "inhibition of purine nucleoside transport" NARROW [] is_a: GO:0032243 ! negative regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport [Term] id: GO:0032248 name: positive regulation of purine nucleoside transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of purine nucleoside transport" NARROW [] synonym: "stimulation of purine nucleoside transport" NARROW [] synonym: "up regulation of purine nucleoside transport" EXACT [] synonym: "up-regulation of purine nucleoside transport" EXACT [] synonym: "upregulation of purine nucleoside transport" EXACT [] is_a: GO:0032244 ! positive regulation of nucleoside transport is_a: GO:0032245 ! regulation of purine nucleoside transport [Term] id: GO:0032249 name: regulation of adenosine transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032245 ! regulation of purine nucleoside transport is_a: GO:2001023 ! regulation of response to drug relationship: regulates GO:0032238 ! adenosine transport [Term] id: GO:0032250 name: negative regulation of adenosine transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of adenosine transport" EXACT [] synonym: "down-regulation of adenosine transport" EXACT [] synonym: "downregulation of adenosine transport" EXACT [] synonym: "inhibition of adenosine transport" NARROW [] is_a: GO:0032247 ! negative regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport is_a: GO:2001024 ! negative regulation of response to drug relationship: negatively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032251 name: positive regulation of adenosine transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of adenosine transport" NARROW [] synonym: "stimulation of adenosine transport" NARROW [] synonym: "up regulation of adenosine transport" EXACT [] synonym: "up-regulation of adenosine transport" EXACT [] synonym: "upregulation of adenosine transport" EXACT [] is_a: GO:0032248 ! positive regulation of purine nucleoside transport is_a: GO:0032249 ! regulation of adenosine transport is_a: GO:2001025 ! positive regulation of response to drug relationship: positively_regulates GO:0032238 ! adenosine transport [Term] id: GO:0032252 name: secretory granule localization namespace: biological_process def: "Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "secretory granule clustering" RELATED [] synonym: "secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051648 ! vesicle localization [Term] id: GO:0032253 name: dense core granule localization namespace: biological_process def: "Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell." [GOC:mah] synonym: "dense core granule clustering" RELATED [] synonym: "dense core granule localisation" EXACT [GOC:mah] synonym: "dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032252 ! secretory granule localization [Term] id: GO:0032254 name: establishment of secretory granule localization namespace: biological_process def: "The directed movement of a secretory granule to a specific location." [GOC:mah] synonym: "establishment of secretory granule localisation" EXACT [GOC:mah] is_a: GO:0051650 ! establishment of vesicle localization relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032255 name: maintenance of secretory granule location namespace: biological_process def: "Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of secretory granule localization" RELATED [GOC:dph, GOC:tb] is_a: GO:0051655 ! maintenance of vesicle location relationship: part_of GO:0032252 ! secretory granule localization [Term] id: GO:0032256 name: establishment of dense core granule localization namespace: biological_process def: "The directed movement of a dense core granule to a specific location." [GOC:mah] synonym: "establishment of dense core granule localisation" EXACT [GOC:mah] synonym: "establishment of dense core vesicle localization" EXACT [GOC:kmv] is_a: GO:0032254 ! establishment of secretory granule localization relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032257 name: maintenance of dense core granule location namespace: biological_process def: "Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere." [GOC:dph, GOC:mah, GOC:tb] synonym: "maintenance of dense core granule localization" RELATED [GOC:dph, GOC:tb] synonym: "maintenance of dense core vesicle location" EXACT [GOC:kmv] is_a: GO:0032255 ! maintenance of secretory granule location relationship: part_of GO:0032253 ! dense core granule localization [Term] id: GO:0032258 name: protein localization by the Cvt pathway namespace: biological_process def: "A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast." [PMID:12865942, PMID:15659643] synonym: "cytoplasm to vacuole targeting" BROAD [] synonym: "cytoplasm-to-vacuole targeting" BROAD [] is_a: GO:0061919 ! process utilizing autophagic mechanism is_a: GO:0072665 ! protein localization to vacuole [Term] id: GO:0032259 name: methylation namespace: biological_process def: "The process in which a methyl group is covalently attached to a molecule." [GOC:mah] subset: goslim_chembl xref: Wikipedia:Methylation is_a: GO:0008152 ! metabolic process [Term] id: GO:0032260 name: response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:mah] synonym: "response to jasmonic acid stimulus during jasmonic acid and ethylene-dependent systemic resistance" RELATED [GOC:dph, GOC:tb] is_a: GO:0009753 ! response to jasmonic acid relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0032261 name: purine nucleotide salvage namespace: biological_process def: "Any process which produces a purine nucleotide from derivatives of it, without de novo synthesis." [GOC:jp] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0043101 ! purine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032262 name: pyrimidine nucleotide salvage namespace: biological_process def: "Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0008655 ! pyrimidine-containing compound salvage is_a: GO:0043173 ! nucleotide salvage [Term] id: GO:0032263 name: GMP salvage namespace: biological_process def: "Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0006177 ! GMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032264 name: IMP salvage namespace: biological_process def: "Any process which produces inosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0006188 ! IMP biosynthetic process is_a: GO:0032261 ! purine nucleotide salvage [Term] id: GO:0032265 name: XMP salvage namespace: biological_process def: "Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis." [GOC:mah] is_a: GO:0032261 ! purine nucleotide salvage is_a: GO:0097293 ! XMP biosynthetic process [Term] id: GO:0032266 name: phosphatidylinositol-3-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position." [GOC:bf, PMID:10209156, PMID:11395417, PMID:11557775] synonym: "phosphatidylinositol 3-phosphate binding" EXACT [] synonym: "PtdIns-3-P binding" EXACT [] is_a: GO:1901981 ! phosphatidylinositol phosphate binding [Term] id: GO:0032267 name: tRNA(Ile)-lysidine synthase activity namespace: molecular_function def: "Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine." [PMID:14527414] synonym: "tRNA(Ile)-2-lysyl-cytidine synthase activity" EXACT [] synonym: "tRNA(Ile)-lysidine synthetase activity" EXACT [] xref: EC:6.3.4 is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds is_a: GO:0140101 ! catalytic activity, acting on a tRNA [Term] id: GO:0032268 name: regulation of cellular protein metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "regulation of cellular protein metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0051246 ! regulation of protein metabolic process relationship: regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032269 name: negative regulation of cellular protein metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "down regulation of cellular protein metabolic process" EXACT [] synonym: "down-regulation of cellular protein metabolic process" EXACT [] synonym: "downregulation of cellular protein metabolic process" EXACT [] synonym: "inhibition of cellular protein metabolic process" NARROW [] synonym: "negative regulation of cellular protein metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051248 ! negative regulation of protein metabolic process relationship: negatively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032270 name: positive regulation of cellular protein metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell." [GOC:mah] synonym: "activation of cellular protein metabolic process" NARROW [] synonym: "positive regulation of cellular protein metabolism" EXACT [] synonym: "stimulation of cellular protein metabolic process" NARROW [] synonym: "up regulation of cellular protein metabolic process" EXACT [] synonym: "up-regulation of cellular protein metabolic process" EXACT [] synonym: "upregulation of cellular protein metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0051247 ! positive regulation of protein metabolic process relationship: positively_regulates GO:0044267 ! cellular protein metabolic process [Term] id: GO:0032271 name: regulation of protein polymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "regulation of protein polymerisation" EXACT [] is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0051258 ! protein polymerization [Term] id: GO:0032272 name: negative regulation of protein polymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "down regulation of protein polymerization" EXACT [] synonym: "down-regulation of protein polymerization" EXACT [] synonym: "downregulation of protein polymerization" EXACT [] synonym: "inhibition of protein polymerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0032271 ! regulation of protein polymerization relationship: negatively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032273 name: positive regulation of protein polymerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers." [GOC:mah] synonym: "activation of protein polymerization" NARROW [] synonym: "stimulation of protein polymerization" NARROW [] synonym: "up regulation of protein polymerization" EXACT [] synonym: "up-regulation of protein polymerization" EXACT [] synonym: "upregulation of protein polymerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0032271 ! regulation of protein polymerization relationship: positively_regulates GO:0051258 ! protein polymerization [Term] id: GO:0032274 name: gonadotropin secretion namespace: biological_process def: "The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone." [GOC:mah, ISBN:0721662544] synonym: "gonadotrophin secretion" EXACT [] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032275 name: luteinizing hormone secretion namespace: biological_process def: "The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary." [ISBN:0198506732] is_a: GO:0032274 ! gonadotropin secretion [Term] id: GO:0032276 name: regulation of gonadotropin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "regulation of gonadotrophin secretion" EXACT [] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032277 name: negative regulation of gonadotropin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "down regulation of gonadotropin secretion" EXACT [] synonym: "down-regulation of gonadotropin secretion" EXACT [] synonym: "downregulation of gonadotropin secretion" EXACT [] synonym: "inhibition of gonadotropin secretion" NARROW [] synonym: "negative regulation of gonadotrophin secretion" EXACT [GOC:dph] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032278 name: positive regulation of gonadotropin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin." [GOC:mah] synonym: "activation of gonadotropin secretion" NARROW [] synonym: "positive regulation of gonadotrophin secretion" EXACT [GOC:dph] synonym: "stimulation of gonadotropin secretion" NARROW [] synonym: "up regulation of gonadotropin secretion" EXACT [] synonym: "up-regulation of gonadotropin secretion" EXACT [] synonym: "upregulation of gonadotropin secretion" EXACT [] is_a: GO:0032276 ! regulation of gonadotropin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0032274 ! gonadotropin secretion [Term] id: GO:0032279 name: asymmetric synapse namespace: cellular_component def: "A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density. Most or all synapses of this type are excitatory." [GOC:dgh, GOC:ef] synonym: "Gray's type I synapse" EXACT [] is_a: GO:0098984 ! neuron to neuron synapse [Term] id: GO:0032280 name: symmetric synapse namespace: cellular_component def: "A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory." [GOC:dgh, GOC:ef] comment: The term 'symmetric' in this name refers only to gross morphology. There is no implication of functional symmetry. synonym: "Gray's type II synapse" EXACT [] is_a: GO:0098984 ! neuron to neuron synapse [Term] id: GO:0032281 name: AMPA glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus." [GOC:ef] synonym: "alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex" EXACT [] synonym: "AMPA receptor" RELATED [] synonym: "AMPA-selective glutamate receptor complex" EXACT [] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034703 ! cation channel complex [Term] id: GO:0032282 name: plastid acetyl-CoA carboxylase complex namespace: cellular_component def: "An acetyl-CoA carboxylase complex located in the stroma of a plastid." [GOC:mah] synonym: "plastid ACCase complex" EXACT [] is_a: GO:0009317 ! acetyl-CoA carboxylase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0032283 name: plastid acetate CoA-transferase complex namespace: cellular_component def: "An acetate CoA-transferase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009329 ! acetate CoA-transferase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032284 name: plastid biotin carboxylase complex namespace: cellular_component def: "A biotin carboxylase complex located in the stroma of a plastid." [GOC:mah] is_a: GO:0009343 ! biotin carboxylase complex is_a: GO:0044435 ! plastid part relationship: part_of GO:0032282 ! plastid acetyl-CoA carboxylase complex [Term] id: GO:0032285 name: non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating glial cell membrane closes around an axon." [GOC:dgh] synonym: "ensheathment of non-myelinated axons" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032286 name: central nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature central nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in central nervous system" EXACT [GOC:curators] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032287 name: peripheral nervous system myelin maintenance namespace: biological_process def: "The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state." [GOC:dgh] synonym: "myelin maintenance in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0043217 ! myelin maintenance relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032288 name: myelin assembly namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system." [GOC:dgh, GOC:dph, GOC:tb] synonym: "myelin formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0042552 ! myelination [Term] id: GO:0032289 name: central nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system." [GOC:dgh] synonym: "myelin formation in central nervous system" EXACT [GOC:curators] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022010 ! central nervous system myelination [Term] id: GO:0032290 name: peripheral nervous system myelin formation namespace: biological_process def: "The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the peripheral nervous system." [GOC:dgh] synonym: "myelin formation in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0032288 ! myelin assembly relationship: part_of GO:0022011 ! myelination in peripheral nervous system [Term] id: GO:0032291 name: axon ensheathment in central nervous system namespace: biological_process def: "The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in central nervous system" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032292 name: peripheral nervous system axon ensheathment namespace: biological_process def: "The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction." [GOC:dgh] synonym: "ensheathment of axons in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0008366 ! axon ensheathment [Term] id: GO:0032293 name: non-myelinated axon ensheathment in central nervous system namespace: biological_process def: "The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in central nervous system" EXACT [GOC:curators] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032291 ! axon ensheathment in central nervous system [Term] id: GO:0032294 name: peripheral nervous system non-myelinated axon ensheathment namespace: biological_process def: "The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons." [GOC:dgh] synonym: "ensheathment of non-myelinated axons in peripheral nervous system" EXACT [GOC:curators] is_a: GO:0032285 ! non-myelinated axon ensheathment is_a: GO:0032292 ! peripheral nervous system axon ensheathment [Term] id: GO:0032295 name: ensheathment of neuronal cell bodies namespace: biological_process def: "The process in which satellite glial cells isolate neuronal cell bodies." [GOC:dgh] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0032296 name: double-stranded RNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in double-stranded RNA molecules." [GOC:mah] synonym: "double-stranded RNA-specific RNase activity" EXACT [] synonym: "dsRNA-specific ribonuclease activity" EXACT [] synonym: "dsRNA-specific RNase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0032297 name: negative regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "down regulation of DNA replication initiation" EXACT [] synonym: "down-regulation of DNA replication initiation" EXACT [] synonym: "downregulation of DNA replication initiation" EXACT [] synonym: "inhibition of DNA replication initiation" NARROW [] synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0051053 ! negative regulation of DNA metabolic process is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0032298 name: positive regulation of DNA-dependent DNA replication initiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication." [GOC:mah] synonym: "activation of DNA replication initiation" NARROW [] synonym: "negative regulation of DNA replication initiation" BROAD [GOC:vw] synonym: "stimulation of DNA replication initiation" NARROW [] synonym: "up regulation of DNA replication initiation" EXACT [] synonym: "up-regulation of DNA replication initiation" EXACT [] synonym: "upregulation of DNA replication initiation" EXACT [] is_a: GO:0030174 ! regulation of DNA-dependent DNA replication initiation is_a: GO:0051054 ! positive regulation of DNA metabolic process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0006270 ! DNA replication initiation [Term] id: GO:0032299 name: ribonuclease H2 complex namespace: cellular_component def: "A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p." [GOC:mah, PMID:14734815] synonym: "RNase H2 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032300 name: mismatch repair complex namespace: cellular_component def: "Any complex formed of proteins that act in mismatch repair." [GOC:mah] subset: goslim_pir is_a: GO:0044424 ! intracellular part is_a: GO:1990391 ! DNA repair complex [Term] id: GO:0032301 name: MutSalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH6 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032302 name: MutSbeta complex namespace: cellular_component def: "A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3." [PMID:11005803] synonym: "MMR complex" BROAD [] synonym: "MSH2/MSH3 complex" EXACT [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032303 name: regulation of icosanoid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "regulation of eicosanoid secretion" EXACT [] is_a: GO:0051046 ! regulation of secretion is_a: GO:2000191 ! regulation of fatty acid transport relationship: regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032304 name: negative regulation of icosanoid secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "down regulation of icosanoid secretion" EXACT [] synonym: "down-regulation of icosanoid secretion" EXACT [] synonym: "downregulation of icosanoid secretion" EXACT [] synonym: "inhibition of icosanoid secretion" NARROW [] synonym: "negative regulation of eicosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051048 ! negative regulation of secretion is_a: GO:2000192 ! negative regulation of fatty acid transport relationship: negatively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032305 name: positive regulation of icosanoid secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell." [GOC:mah] synonym: "activation of icosanoid secretion" NARROW [] synonym: "positive regulation of eicosanoid secretion" EXACT [] synonym: "stimulation of icosanoid secretion" NARROW [] synonym: "up regulation of icosanoid secretion" EXACT [] synonym: "up-regulation of icosanoid secretion" EXACT [] synonym: "upregulation of icosanoid secretion" EXACT [] is_a: GO:0032303 ! regulation of icosanoid secretion is_a: GO:0051047 ! positive regulation of secretion is_a: GO:2000193 ! positive regulation of fatty acid transport relationship: positively_regulates GO:0032309 ! icosanoid secretion [Term] id: GO:0032306 name: regulation of prostaglandin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "regulation of prostacyclin secretion" NARROW [] is_a: GO:0032303 ! regulation of icosanoid secretion relationship: regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032307 name: negative regulation of prostaglandin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "down regulation of prostaglandin secretion" EXACT [] synonym: "down-regulation of prostaglandin secretion" EXACT [] synonym: "downregulation of prostaglandin secretion" EXACT [] synonym: "inhibition of prostaglandin secretion" NARROW [] synonym: "negative regulation of prostacyclin secretion" NARROW [] is_a: GO:0032304 ! negative regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion relationship: negatively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032308 name: positive regulation of prostaglandin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell." [GOC:mah] synonym: "activation of prostaglandin secretion" NARROW [] synonym: "positive regulation of prostacyclin secretion" NARROW [] synonym: "stimulation of prostaglandin secretion" NARROW [] synonym: "up regulation of prostaglandin secretion" EXACT [] synonym: "up-regulation of prostaglandin secretion" EXACT [] synonym: "upregulation of prostaglandin secretion" EXACT [] is_a: GO:0032305 ! positive regulation of icosanoid secretion is_a: GO:0032306 ! regulation of prostaglandin secretion relationship: positively_regulates GO:0032310 ! prostaglandin secretion [Term] id: GO:0032309 name: icosanoid secretion namespace: biological_process def: "The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue." [GOC:mah] synonym: "eicosanoid secretion" EXACT [] is_a: GO:0046717 ! acid secretion is_a: GO:0071715 ! icosanoid transport [Term] id: GO:0032310 name: prostaglandin secretion namespace: biological_process def: "The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue." [GOC:mah] synonym: "prostacyclin secretion" NARROW [] is_a: GO:0015732 ! prostaglandin transport is_a: GO:0032309 ! icosanoid secretion [Term] id: GO:0032311 name: angiogenin-PRI complex namespace: cellular_component def: "A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis." [PMID:2706246, PMID:3470787] synonym: "angiogenin-placental ribonuclease inhibitor complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044421 ! extracellular region part [Term] id: GO:0032322 name: ubiquinone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] synonym: "ubiquinone breakdown" EXACT [] synonym: "ubiquinone catabolism" EXACT [] synonym: "ubiquinone degradation" EXACT [] is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:1901662 ! quinone catabolic process [Term] id: GO:0032323 name: lipoate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipoate." [GOC:mah] synonym: "lipoic acid breakdown" EXACT [] synonym: "lipoic acid catabolism" EXACT [] synonym: "lipoic acid degradation" EXACT [] is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0009106 ! lipoate metabolic process is_a: GO:0044273 ! sulfur compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0032324 name: molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "molybdopterin cofactor anabolism" EXACT [] synonym: "molybdopterin cofactor biosynthesis" RELATED [] synonym: "molybdopterin cofactor formation" RELATED [] synonym: "molybdopterin cofactor synthesis" EXACT [] xref: MetaCyc:Molybdenum-Cofactor-Biosynthesis is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0032325 name: molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands." [GOC:mah] is_a: GO:0043545 ! molybdopterin cofactor metabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:0051187 ! cofactor catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0032326 name: Mo-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "Mo-molybdopterin cofactor breakdown" EXACT [] synonym: "Mo-molybdopterin cofactor catabolism" EXACT [] synonym: "Mo-molybdopterin cofactor degradation" EXACT [] synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process [Term] id: GO:0032327 name: W-molybdopterin cofactor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands." [GOC:mah] synonym: "Moco catabolic process" BROAD [] synonym: "Moco catabolism" BROAD [] synonym: "W-molybdopterin cofactor breakdown" EXACT [] synonym: "W-molybdopterin cofactor catabolism" EXACT [] synonym: "W-molybdopterin cofactor degradation" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0032325 ! molybdopterin cofactor catabolic process is_a: GO:0042046 ! W-molybdopterin cofactor metabolic process [Term] id: GO:0032328 name: alanine transport namespace: biological_process def: "The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0032329 name: serine transport namespace: biological_process alt_id: GO:0090478 def: "The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "serine import" NARROW [] is_a: GO:0006812 ! cation transport is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0032330 name: regulation of chondrocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] is_a: GO:0045595 ! regulation of cell differentiation is_a: GO:0061035 ! regulation of cartilage development relationship: regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032331 name: negative regulation of chondrocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "down regulation of chondrocyte differentiation" EXACT [] synonym: "down-regulation of chondrocyte differentiation" EXACT [] synonym: "downregulation of chondrocyte differentiation" EXACT [] synonym: "inhibition of chondrocyte differentiation" NARROW [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0061037 ! negative regulation of cartilage development relationship: negatively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032332 name: positive regulation of chondrocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation." [GOC:mah] synonym: "activation of chondrocyte differentiation" NARROW [] synonym: "stimulation of chondrocyte differentiation" NARROW [] synonym: "up regulation of chondrocyte differentiation" EXACT [] synonym: "up-regulation of chondrocyte differentiation" EXACT [] synonym: "upregulation of chondrocyte differentiation" EXACT [] is_a: GO:0032330 ! regulation of chondrocyte differentiation is_a: GO:0045597 ! positive regulation of cell differentiation is_a: GO:0061036 ! positive regulation of cartilage development relationship: positively_regulates GO:0002062 ! chondrocyte differentiation [Term] id: GO:0032333 name: activin secretion namespace: biological_process def: "The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone." [GOC:mah] is_a: GO:0046879 ! hormone secretion [Term] id: GO:0032334 name: inhibin secretion namespace: biological_process def: "The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone." [GOC:mah] is_a: GO:0060986 ! endocrine hormone secretion [Term] id: GO:0032335 name: regulation of activin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032333 ! activin secretion [Term] id: GO:0032336 name: negative regulation of activin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] synonym: "down regulation of activin secretion" EXACT [] synonym: "down-regulation of activin secretion" EXACT [] synonym: "downregulation of activin secretion" EXACT [] synonym: "inhibition of activin secretion" NARROW [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032337 name: positive regulation of activin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell." [GOC:mah] synonym: "activation of activin secretion" NARROW [] synonym: "stimulation of activin secretion" NARROW [] synonym: "up regulation of activin secretion" EXACT [] synonym: "up-regulation of activin secretion" EXACT [] synonym: "upregulation of activin secretion" EXACT [] is_a: GO:0032335 ! regulation of activin secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0032333 ! activin secretion [Term] id: GO:0032338 name: regulation of inhibin secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion relationship: regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032339 name: negative regulation of inhibin secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] synonym: "down regulation of inhibin secretion" EXACT [] synonym: "down-regulation of inhibin secretion" EXACT [] synonym: "downregulation of inhibin secretion" EXACT [] synonym: "inhibition of inhibin secretion" NARROW [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046888 ! negative regulation of hormone secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032340 name: positive regulation of inhibin secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell." [GOC:mah] synonym: "activation of inhibin secretion" NARROW [] synonym: "stimulation of inhibin secretion" NARROW [] synonym: "up regulation of inhibin secretion" EXACT [] synonym: "up-regulation of inhibin secretion" EXACT [] synonym: "upregulation of inhibin secretion" EXACT [] is_a: GO:0032338 ! regulation of inhibin secretion is_a: GO:0046887 ! positive regulation of hormone secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0032334 ! inhibin secretion [Term] id: GO:0032341 name: aldosterone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] synonym: "aldosterone metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0034308 ! primary alcohol metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0032342 name: aldosterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0006705 ! mineralocorticoid biosynthetic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034309 ! primary alcohol biosynthetic process is_a: GO:0042181 ! ketone biosynthetic process is_a: GO:0046184 ! aldehyde biosynthetic process [Term] id: GO:0032343 name: aldosterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance." [PMID:16527843] is_a: GO:0006712 ! mineralocorticoid catabolic process is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0032341 ! aldosterone metabolic process is_a: GO:0034310 ! primary alcohol catabolic process is_a: GO:0042182 ! ketone catabolic process is_a: GO:0046185 ! aldehyde catabolic process [Term] id: GO:0032344 name: regulation of aldosterone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "regulation of aldosterone metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032345 name: negative regulation of aldosterone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "down regulation of aldosterone metabolic process" EXACT [] synonym: "down-regulation of aldosterone metabolic process" EXACT [] synonym: "downregulation of aldosterone metabolic process" EXACT [] synonym: "inhibition of aldosterone metabolic process" NARROW [] synonym: "negative regulation of aldosterone metabolism" EXACT [] is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0045939 ! negative regulation of steroid metabolic process is_a: GO:0062014 ! negative regulation of small molecule metabolic process relationship: negatively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032346 name: positive regulation of aldosterone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone." [GOC:mah] synonym: "activation of aldosterone metabolic process" NARROW [] synonym: "positive regulation of aldosterone metabolism" EXACT [] synonym: "stimulation of aldosterone metabolic process" NARROW [] synonym: "up regulation of aldosterone metabolic process" EXACT [] synonym: "up-regulation of aldosterone metabolic process" EXACT [] synonym: "upregulation of aldosterone metabolic process" EXACT [] is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0032352 ! positive regulation of hormone metabolic process is_a: GO:0045940 ! positive regulation of steroid metabolic process is_a: GO:0062013 ! positive regulation of small molecule metabolic process relationship: positively_regulates GO:0032341 ! aldosterone metabolic process [Term] id: GO:0032347 name: regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0032344 ! regulation of aldosterone metabolic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process relationship: regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032348 name: negative regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "down regulation of aldosterone biosynthetic process" EXACT [] synonym: "down-regulation of aldosterone biosynthetic process" EXACT [] synonym: "downregulation of aldosterone biosynthetic process" EXACT [] synonym: "inhibition of aldosterone biosynthetic process" NARROW [] is_a: GO:0032345 ! negative regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process is_a: GO:1902931 ! negative regulation of alcohol biosynthetic process relationship: negatively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032349 name: positive regulation of aldosterone biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone." [GOC:mah] synonym: "activation of aldosterone biosynthetic process" NARROW [] synonym: "stimulation of aldosterone biosynthetic process" NARROW [] synonym: "up regulation of aldosterone biosynthetic process" EXACT [] synonym: "up-regulation of aldosterone biosynthetic process" EXACT [] synonym: "upregulation of aldosterone biosynthetic process" EXACT [] is_a: GO:0032346 ! positive regulation of aldosterone metabolic process is_a: GO:0032347 ! regulation of aldosterone biosynthetic process is_a: GO:0090031 ! positive regulation of steroid hormone biosynthetic process is_a: GO:1902932 ! positive regulation of alcohol biosynthetic process relationship: positively_regulates GO:0032342 ! aldosterone biosynthetic process [Term] id: GO:0032350 name: regulation of hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "regulation of hormone metabolism" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0019222 ! regulation of metabolic process relationship: regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032351 name: negative regulation of hormone metabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "down regulation of hormone metabolic process" EXACT [] synonym: "down-regulation of hormone metabolic process" EXACT [] synonym: "downregulation of hormone metabolic process" EXACT [] synonym: "inhibition of hormone metabolic process" NARROW [] synonym: "negative regulation of hormone metabolism" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: negatively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032352 name: positive regulation of hormone metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone." [GOC:mah] synonym: "activation of hormone metabolic process" NARROW [] synonym: "positive regulation of hormone metabolism" EXACT [] synonym: "stimulation of hormone metabolic process" NARROW [] synonym: "up regulation of hormone metabolic process" EXACT [] synonym: "up-regulation of hormone metabolic process" EXACT [] synonym: "upregulation of hormone metabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process relationship: positively_regulates GO:0042445 ! hormone metabolic process [Term] id: GO:0032353 name: negative regulation of hormone biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones." [GOC:ai] synonym: "down regulation of hormone biosynthetic process" EXACT [] synonym: "down-regulation of hormone biosynthetic process" EXACT [] synonym: "downregulation of hormone biosynthetic process" EXACT [] synonym: "inhibition of hormone biosynthetic process" NARROW [] is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0032351 ! negative regulation of hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process relationship: negatively_regulates GO:0042446 ! hormone biosynthetic process [Term] id: GO:0032354 name: response to follicle-stimulating hormone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus." [GOC:mah] synonym: "response to follicle stimulating hormone stimulus" EXACT [] synonym: "response to follicle-stimulating hormone stimulus" EXACT [GOC:dos] synonym: "response to FSH stimulus" EXACT [] is_a: GO:0034698 ! response to gonadotropin [Term] id: GO:0032355 name: response to estradiol namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen." [GOC:mah, ISBN:0911910123] synonym: "response to E2 stimulus" EXACT [] synonym: "response to estradiol stimulus" EXACT [GOC:dos] is_a: GO:0009725 ! response to hormone is_a: GO:0014070 ! response to organic cyclic compound is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032356 name: oxidized DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized residues in DNA." [GOC:vk] synonym: "oxidised DNA binding" EXACT [] is_a: GO:0003684 ! damaged DNA binding [Term] id: GO:0032357 name: oxidized purine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized purine residues in DNA." [GOC:vk] synonym: "oxidised purine DNA binding" EXACT [] synonym: "oxidized purine base DNA binding" EXACT [CHEBI:26386] synonym: "oxidized purine nucleobase DNA binding" EXACT [CHEBI:26386] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032358 name: oxidized pyrimidine DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxidized pyrimidine residues in DNA." [GOC:vk] synonym: "oxidised pyrimidine DNA binding" EXACT [] synonym: "oxidized pyrimidine base DNA binding" EXACT [CHEBI:26432] synonym: "oxidized pyrimidine nucleobase DNA binding" EXACT [CHEBI:26432] is_a: GO:0032356 ! oxidized DNA binding [Term] id: GO:0032359 name: provirus excision namespace: biological_process def: "The molecular events that lead to the excision of a viral genome from the host genome." [GOC:mlg] synonym: "prophage excision" EXACT [] is_a: GO:0019046 ! release from viral latency [Term] id: GO:0032361 name: pyridoxal phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6." [GOC:mah] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042820 ! vitamin B6 catabolic process is_a: GO:0042822 ! pyridoxal phosphate metabolic process is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046434 ! organophosphate catabolic process is_a: GO:1901616 ! organic hydroxy compound catabolic process [Term] id: GO:0032362 name: obsolete FAD catabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the breakdown of FAD, the oxidized form of flavin-adenine dinucleotide." [CHEBI:16238, GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "FAD breakdown" EXACT [GOC:mah] synonym: "FAD catabolism" EXACT [GOC:mah] synonym: "FAD degradation" EXACT [GOC:mah] synonym: "oxidized flavin adenine dinucleotide catabolic process" EXACT [GOC:mah] is_obsolete: true [Term] id: GO:0032363 name: FMN catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:mah] is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009261 ! ribonucleotide catabolic process is_a: GO:0042728 ! flavin-containing compound catabolic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0032364 name: oxygen homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell." [GOC:rph] is_a: GO:0033483 ! gas homeostasis [Term] id: GO:0032365 name: intracellular lipid transport namespace: biological_process def: "The directed movement of lipids within cells." [GOC:mah] is_a: GO:0006869 ! lipid transport is_a: GO:0046907 ! intracellular transport [Term] id: GO:0032366 name: intracellular sterol transport namespace: biological_process def: "The directed movement of sterols within cells." [GOC:mah] is_a: GO:0015918 ! sterol transport is_a: GO:0032365 ! intracellular lipid transport [Term] id: GO:0032367 name: intracellular cholesterol transport namespace: biological_process def: "The directed movement of cholesterol, cholest-5-en-3-beta-ol, within cells." [GOC:mah] is_a: GO:0030301 ! cholesterol transport is_a: GO:0032366 ! intracellular sterol transport [Term] id: GO:0032368 name: regulation of lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:1905952 ! regulation of lipid localization relationship: regulates GO:0006869 ! lipid transport [Term] id: GO:0032369 name: negative regulation of lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of lipid transport" EXACT [] synonym: "down-regulation of lipid transport" EXACT [] synonym: "downregulation of lipid transport" EXACT [] synonym: "inhibition of lipid transport" NARROW [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051051 ! negative regulation of transport is_a: GO:1905953 ! negative regulation of lipid localization relationship: negatively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032370 name: positive regulation of lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of lipid transport" NARROW [] synonym: "stimulation of lipid transport" NARROW [] synonym: "up regulation of lipid transport" EXACT [] synonym: "up-regulation of lipid transport" EXACT [] synonym: "upregulation of lipid transport" EXACT [] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0051050 ! positive regulation of transport is_a: GO:1905954 ! positive regulation of lipid localization relationship: positively_regulates GO:0006869 ! lipid transport [Term] id: GO:0032371 name: regulation of sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport relationship: regulates GO:0015918 ! sterol transport [Term] id: GO:0032372 name: negative regulation of sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of sterol transport" EXACT [] synonym: "down-regulation of sterol transport" EXACT [] synonym: "downregulation of sterol transport" EXACT [] synonym: "inhibition of sterol transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport relationship: negatively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032373 name: positive regulation of sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of sterol transport" NARROW [] synonym: "stimulation of sterol transport" NARROW [] synonym: "up regulation of sterol transport" EXACT [] synonym: "up-regulation of sterol transport" EXACT [] synonym: "upregulation of sterol transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032371 ! regulation of sterol transport relationship: positively_regulates GO:0015918 ! sterol transport [Term] id: GO:0032374 name: regulation of cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport relationship: regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032375 name: negative regulation of cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of cholesterol transport" EXACT [] synonym: "down-regulation of cholesterol transport" EXACT [] synonym: "downregulation of cholesterol transport" EXACT [] synonym: "inhibition of cholesterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport relationship: negatively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032376 name: positive regulation of cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of cholesterol transport" NARROW [] synonym: "stimulation of cholesterol transport" NARROW [] synonym: "up regulation of cholesterol transport" EXACT [] synonym: "up-regulation of cholesterol transport" EXACT [] synonym: "upregulation of cholesterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032374 ! regulation of cholesterol transport relationship: positively_regulates GO:0030301 ! cholesterol transport [Term] id: GO:0032377 name: regulation of intracellular lipid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] is_a: GO:0032368 ! regulation of lipid transport is_a: GO:0032386 ! regulation of intracellular transport relationship: regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032378 name: negative regulation of intracellular lipid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "down regulation of intracellular lipid transport" EXACT [] synonym: "down-regulation of intracellular lipid transport" EXACT [] synonym: "downregulation of intracellular lipid transport" EXACT [] synonym: "inhibition of intracellular lipid transport" NARROW [] is_a: GO:0032369 ! negative regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032387 ! negative regulation of intracellular transport relationship: negatively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032379 name: positive regulation of intracellular lipid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells." [GOC:mah] synonym: "activation of intracellular lipid transport" NARROW [] synonym: "stimulation of intracellular lipid transport" NARROW [] synonym: "up regulation of intracellular lipid transport" EXACT [] synonym: "up-regulation of intracellular lipid transport" EXACT [] synonym: "upregulation of intracellular lipid transport" EXACT [] is_a: GO:0032370 ! positive regulation of lipid transport is_a: GO:0032377 ! regulation of intracellular lipid transport is_a: GO:0032388 ! positive regulation of intracellular transport relationship: positively_regulates GO:0032365 ! intracellular lipid transport [Term] id: GO:0032380 name: regulation of intracellular sterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] is_a: GO:0032371 ! regulation of sterol transport is_a: GO:0032377 ! regulation of intracellular lipid transport relationship: regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032381 name: negative regulation of intracellular sterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "down regulation of intracellular sterol transport" EXACT [] synonym: "down-regulation of intracellular sterol transport" EXACT [] synonym: "downregulation of intracellular sterol transport" EXACT [] synonym: "inhibition of intracellular sterol transport" NARROW [] is_a: GO:0032372 ! negative regulation of sterol transport is_a: GO:0032378 ! negative regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: negatively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032382 name: positive regulation of intracellular sterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells." [GOC:mah] synonym: "activation of intracellular sterol transport" NARROW [] synonym: "stimulation of intracellular sterol transport" NARROW [] synonym: "up regulation of intracellular sterol transport" EXACT [] synonym: "up-regulation of intracellular sterol transport" EXACT [] synonym: "upregulation of intracellular sterol transport" EXACT [] is_a: GO:0032373 ! positive regulation of sterol transport is_a: GO:0032379 ! positive regulation of intracellular lipid transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: positively_regulates GO:0032366 ! intracellular sterol transport [Term] id: GO:0032383 name: regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] is_a: GO:0032374 ! regulation of cholesterol transport is_a: GO:0032380 ! regulation of intracellular sterol transport relationship: regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032384 name: negative regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "down regulation of intracellular cholesterol transport" EXACT [] synonym: "down-regulation of intracellular cholesterol transport" EXACT [] synonym: "downregulation of intracellular cholesterol transport" EXACT [] synonym: "inhibition of intracellular cholesterol transport" NARROW [] is_a: GO:0032375 ! negative regulation of cholesterol transport is_a: GO:0032381 ! negative regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport relationship: negatively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032385 name: positive regulation of intracellular cholesterol transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells." [GOC:mah] synonym: "activation of intracellular cholesterol transport" NARROW [] synonym: "stimulation of intracellular cholesterol transport" NARROW [] synonym: "up regulation of intracellular cholesterol transport" EXACT [] synonym: "up-regulation of intracellular cholesterol transport" EXACT [] synonym: "upregulation of intracellular cholesterol transport" EXACT [] is_a: GO:0032376 ! positive regulation of cholesterol transport is_a: GO:0032382 ! positive regulation of intracellular sterol transport is_a: GO:0032383 ! regulation of intracellular cholesterol transport relationship: positively_regulates GO:0032367 ! intracellular cholesterol transport [Term] id: GO:0032386 name: regulation of intracellular transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] is_a: GO:0051049 ! regulation of transport is_a: GO:0060341 ! regulation of cellular localization relationship: regulates GO:0046907 ! intracellular transport [Term] id: GO:0032387 name: negative regulation of intracellular transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "down regulation of intracellular transport" EXACT [] synonym: "down-regulation of intracellular transport" EXACT [] synonym: "downregulation of intracellular transport" EXACT [] synonym: "inhibition of intracellular transport" NARROW [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032388 name: positive regulation of intracellular transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells." [GOC:mah] synonym: "activation of intracellular transport" NARROW [] synonym: "stimulation of intracellular transport" NARROW [] synonym: "up regulation of intracellular transport" EXACT [] synonym: "up-regulation of intracellular transport" EXACT [] synonym: "upregulation of intracellular transport" EXACT [] is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0046907 ! intracellular transport [Term] id: GO:0032389 name: MutLalpha complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2." [GOC:vk] synonym: "MLH1/PMS2 complex" EXACT [] synonym: "MMR complex" BROAD [] synonym: "MutL-alpha complex" EXACT [CORUM:292] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032390 name: MutLbeta complex namespace: cellular_component def: "A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1." [GOC:vk] synonym: "MLH1/PMS1 complex" EXACT [] synonym: "MMR complex" BROAD [] is_a: GO:0032300 ! mismatch repair complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032391 name: photoreceptor connecting cilium namespace: cellular_component def: "The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone." [GOC:cilia, PMID:15917207, PMID:22653444, PMID:8718680] synonym: "photoreceptor cilium" RELATED [] is_a: GO:0035869 ! ciliary transition zone is_a: GO:0097458 ! neuron part relationship: part_of GO:0097733 ! photoreceptor cell cilium [Term] id: GO:0032392 name: DNA geometric change namespace: biological_process def: "The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases." [GOC:mah] comment: Note that DNA geometric change and DNA topological change (GO:0006265) are distinct, but are usually coupled in vivo. subset: goslim_pir is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0032393 name: MHC class I receptor activity namespace: molecular_function def: "Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class I protein complexes, not for components of the MHC class I protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0032394 name: MHC class Ib receptor activity namespace: molecular_function def: "Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class Ib protein complexes, not for components of the MHC class Ib protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0032395 name: MHC class II receptor activity namespace: molecular_function def: "Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity." [GOC:add, GOC:signaling, ISBN:0781735149] comment: Note that this term is intended for annotation of gene products that act as receptors for MHC class II protein complexes, not for components of the MHC class II protein complexes themselves. synonym: "alpha-beta T cell receptor activity" RELATED [] synonym: "gamma-delta T cell receptor activity" RELATED [] synonym: "T cell receptor activity" RELATED [] is_a: GO:0004888 ! transmembrane signaling receptor activity [Term] id: GO:0032396 name: inhibitory MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte." [GOC:add, PMID:11858820, PMID:9368779, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032397 name: activating MHC class I receptor activity namespace: molecular_function def: "Combining with a MHC class I protein complex to mediate signaling that activates a lymphocyte." [GOC:add, PMID:11858820, PMID:9597134] is_a: GO:0032393 ! MHC class I receptor activity [Term] id: GO:0032398 name: MHC class Ib protein complex namespace: cellular_component def: "A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, ISBN:0781735149, PMID:15928678] is_a: GO:0042611 ! MHC protein complex [Term] id: GO:0032399 name: HECT domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with a HECT, 'Homologous to the E6-AP Carboxy-Terminus', domain of a protein." [GOC:mah, Pfam:PF00632] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032400 name: melanosome localization namespace: biological_process def: "Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell." [GOC:ln] synonym: "melanosome localisation" EXACT [GOC:mah] is_a: GO:0051875 ! pigment granule localization [Term] id: GO:0032401 name: establishment of melanosome localization namespace: biological_process def: "The directed movement of a melanosome to a specific location." [GOC:mah] synonym: "establishment of melanosome localisation" EXACT [GOC:mah] is_a: GO:0051905 ! establishment of pigment granule localization relationship: part_of GO:0032400 ! melanosome localization [Term] id: GO:0032402 name: melanosome transport namespace: biological_process def: "The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:ln] is_a: GO:0032400 ! melanosome localization is_a: GO:0032401 ! establishment of melanosome localization is_a: GO:0051904 ! pigment granule transport [Term] id: GO:0032404 name: mismatch repair complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with a mismatch repair complex." [GOC:vk] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0032405 name: MutLalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032406 name: MutLbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutLbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032407 name: MutSalpha complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSalpha." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032408 name: MutSbeta complex binding namespace: molecular_function def: "Interacting selectively and non-covalently with the mismatch repair complex MutSbeta." [GOC:vk] is_a: GO:0032404 ! mismatch repair complex binding [Term] id: GO:0032409 name: regulation of transporter activity namespace: biological_process def: "Any process that modulates the activity of a transporter." [GOC:mah] is_a: GO:0065009 ! regulation of molecular function [Term] id: GO:0032410 name: negative regulation of transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a transporter." [GOC:mah] synonym: "down regulation of transporter activity" EXACT [] synonym: "down-regulation of transporter activity" EXACT [] synonym: "downregulation of transporter activity" EXACT [] synonym: "inhibition of transporter activity" NARROW [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044092 ! negative regulation of molecular function is_a: GO:0051051 ! negative regulation of transport [Term] id: GO:0032411 name: positive regulation of transporter activity namespace: biological_process def: "Any process that activates or increases the activity of a transporter." [GOC:mah] synonym: "activation of transporter activity" NARROW [] synonym: "stimulation of transporter activity" NARROW [] synonym: "up regulation of transporter activity" EXACT [] synonym: "up-regulation of transporter activity" EXACT [] synonym: "upregulation of transporter activity" EXACT [] is_a: GO:0032409 ! regulation of transporter activity is_a: GO:0044093 ! positive regulation of molecular function is_a: GO:0051050 ! positive regulation of transport [Term] id: GO:0032412 name: regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that modulates the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0022898 ! regulation of transmembrane transporter activity is_a: GO:0034765 ! regulation of ion transmembrane transport [Term] id: GO:0032413 name: negative regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that stops or reduces the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "down regulation of ion transporter activity" EXACT [] synonym: "down-regulation of ion transporter activity" EXACT [] synonym: "downregulation of ion transporter activity" EXACT [] synonym: "inhibition of ion transporter activity" NARROW [] synonym: "negative regulation of ion transporter activity" EXACT [GOC:tb] is_a: GO:0032410 ! negative regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034766 ! negative regulation of ion transmembrane transport [Term] id: GO:0032414 name: positive regulation of ion transmembrane transporter activity namespace: biological_process def: "Any process that activates or increases the activity of an ion transporter." [GOC:mah, GOC:tb] synonym: "activation of ion transporter activity" NARROW [] synonym: "positive regulation of ion transporter activity" EXACT [GOC:tb] synonym: "stimulation of ion transporter activity" NARROW [] synonym: "up regulation of ion transporter activity" EXACT [] synonym: "up-regulation of ion transporter activity" EXACT [] synonym: "upregulation of ion transporter activity" EXACT [] is_a: GO:0032411 ! positive regulation of transporter activity is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0034767 ! positive regulation of ion transmembrane transport [Term] id: GO:0032415 name: regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah, GOC:mtg_transport] synonym: "regulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0010155 ! regulation of proton transport is_a: GO:2000649 ! regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032416 name: negative regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "down regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "down-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "downregulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "inhibition of sodium:hydrogen antiporter activity" NARROW [] synonym: "negative regulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0032415 ! regulation of sodium:proton antiporter activity is_a: GO:2000650 ! negative regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032417 name: positive regulation of sodium:proton antiporter activity namespace: biological_process def: "Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out)." [GOC:mah] synonym: "activation of sodium:hydrogen antiporter activity" NARROW [] synonym: "positive regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "stimulation of sodium:hydrogen antiporter activity" NARROW [] synonym: "up regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "up-regulation of sodium:hydrogen antiporter activity" EXACT [] synonym: "upregulation of sodium:hydrogen antiporter activity" EXACT [] is_a: GO:0032415 ! regulation of sodium:proton antiporter activity is_a: GO:2000651 ! positive regulation of sodium ion transmembrane transporter activity [Term] id: GO:0032418 name: lysosome localization namespace: biological_process def: "Any process in which a lysosome is transported to, and/or maintained in, a specific location." [GOC:mah] synonym: "lysosome localisation" EXACT [GOC:mah] is_a: GO:0051640 ! organelle localization [Term] id: GO:0032419 name: extrinsic component of lysosome membrane namespace: cellular_component def: "The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region." [GOC:dos, GOC:mah] synonym: "extrinsic to lysosomal membrane" EXACT [] synonym: "extrinsic to lysosome membrane" EXACT [] is_a: GO:0000306 ! extrinsic component of vacuolar membrane relationship: part_of GO:0005765 ! lysosomal membrane [Term] id: GO:0032420 name: stereocilium namespace: cellular_component def: "An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles." [GOC:ecd, PMID:15661519, PMID:7840137] is_a: GO:0043005 ! neuron projection is_a: GO:0044422 ! organelle part is_a: GO:0098858 ! actin-based cell projection relationship: part_of GO:0032421 ! stereocilium bundle [Term] id: GO:0032421 name: stereocilium bundle namespace: cellular_component def: "A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes." [GOC:ecd, PMID:15661519, PMID:7840137] subset: goslim_pir synonym: "stereocilia bundle" EXACT [] is_a: GO:0097458 ! neuron part is_a: GO:0098862 ! cluster of actin-based cell projections [Term] id: GO:0032422 name: purine-rich negative regulatory element binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes." [GOC:mah, PMID:9819411] synonym: "PNR element binding" BROAD [] is_a: GO:0044212 ! transcription regulatory region DNA binding is_a: GO:1990837 ! sequence-specific double-stranded DNA binding [Term] id: GO:0032423 name: regulation of mismatch repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mismatch repair." [GOC:vk] is_a: GO:0006282 ! regulation of DNA repair relationship: regulates GO:0006298 ! mismatch repair [Term] id: GO:0032424 name: negative regulation of mismatch repair namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "down regulation of mismatch repair" EXACT [] synonym: "down-regulation of mismatch repair" EXACT [] synonym: "downregulation of mismatch repair" EXACT [] synonym: "inhibition of mismatch repair" NARROW [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045738 ! negative regulation of DNA repair relationship: negatively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032425 name: positive regulation of mismatch repair namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mismatch repair." [GOC:vk] synonym: "activation of mismatch repair" NARROW [] synonym: "stimulation of mismatch repair" NARROW [] synonym: "up regulation of mismatch repair" EXACT [] synonym: "up-regulation of mismatch repair" EXACT [] synonym: "upregulation of mismatch repair" EXACT [] is_a: GO:0032423 ! regulation of mismatch repair is_a: GO:0045739 ! positive regulation of DNA repair relationship: positively_regulates GO:0006298 ! mismatch repair [Term] id: GO:0032426 name: stereocilium tip namespace: cellular_component def: "A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation." [GOC:ecd, GOC:krc, PMID:17021180, PMID:27565685] is_a: GO:0044422 ! organelle part is_a: GO:0097458 ! neuron part is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0032420 ! stereocilium [Term] id: GO:0032427 name: GBD domain binding namespace: molecular_function def: "Interacting selectively and non-covalently with the GTPase protein binding domain (GDB) domain of a protein. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac." [GOC:mah, GOC:pg, PMID:9119069] synonym: "Cdc42/Rac interactive binding motif binding" EXACT [PMID:9119069] synonym: "CRIB motif binding" EXACT [PMID:9119069] synonym: "P21-Rho-binding domain binding" EXACT [GOC:rl] synonym: "PMD binding" EXACT [GOC:rl] is_a: GO:0019904 ! protein domain specific binding [Term] id: GO:0032428 name: beta-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides." [EC:3.2.1.53] xref: EC:3.2.1.53 xref: MetaCyc:3.2.1.53-RXN is_a: GO:0004563 ! beta-N-acetylhexosaminidase activity [Term] id: GO:0032429 name: regulation of phospholipase A2 activity namespace: biological_process def: "Any process that modulates the activity of the enzyme phospholipase A2." [GOC:mah] is_a: GO:0010517 ! regulation of phospholipase activity [Term] id: GO:0032430 name: positive regulation of phospholipase A2 activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme phospholipase A2." [GOC:mah] synonym: "activation of phospholipase A2 activity" NARROW [] synonym: "stimulation of phospholipase A2 activity" NARROW [] synonym: "up regulation of phospholipase A2 activity" EXACT [] synonym: "up-regulation of phospholipase A2 activity" EXACT [] synonym: "upregulation of phospholipase A2 activity" EXACT [] is_a: GO:0010518 ! positive regulation of phospholipase activity is_a: GO:0032429 ! regulation of phospholipase A2 activity [Term] id: GO:0032431 name: activation of phospholipase A2 activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme phospholipase A2." [GOC:mah] synonym: "phospholipase A2 activation" EXACT [] is_a: GO:0032430 ! positive regulation of phospholipase A2 activity [Term] id: GO:0032432 name: actin filament bundle namespace: cellular_component alt_id: GO:0000141 alt_id: GO:0030482 def: "An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness." [GOC:mah] synonym: "actin cable" RELATED [GOC:mah] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0032433 name: filopodium tip namespace: cellular_component def: "The end of a filopodium distal to the body of the cell." [GOC:mah] is_a: GO:0120038 ! plasma membrane bounded cell projection part relationship: part_of GO:0030175 ! filopodium [Term] id: GO:0032434 name: regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] is_a: GO:0061136 ! regulation of proteasomal protein catabolic process is_a: GO:2000058 ! regulation of ubiquitin-dependent protein catabolic process relationship: regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032435 name: negative regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "down regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "down-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "downregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "inhibition of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901799 ! negative regulation of proteasomal protein catabolic process is_a: GO:2000059 ! negative regulation of ubiquitin-dependent protein catabolic process relationship: negatively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032436 name: positive regulation of proteasomal ubiquitin-dependent protein catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome." [GOC:mah] synonym: "activation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "stimulation of proteasomal ubiquitin-dependent protein catabolic process" NARROW [] synonym: "up regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "up-regulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] synonym: "upregulation of proteasomal ubiquitin-dependent protein catabolic process" EXACT [] is_a: GO:0032434 ! regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:1901800 ! positive regulation of proteasomal protein catabolic process is_a: GO:2000060 ! positive regulation of ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0043161 ! proteasome-mediated ubiquitin-dependent protein catabolic process [Term] id: GO:0032437 name: cuticular plate namespace: cellular_component def: "A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted." [PMID:12485990, PMID:2592408, PMID:8071151] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0097458 ! neuron part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0032438 name: melanosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored." [GOC:vk] synonym: "melanosome organisation" EXACT [GOC:mah] synonym: "melanosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0032440 name: 2-alkenal reductase [NAD(P)] activity namespace: molecular_function def: "Catalysis of the reaction: n-alkanal + NAD(P)+ = alk-2-enal + NAD(P)H + H+." [EC:1.3.1.74, PMID:16299173] synonym: "n-alkanal:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.3.1.74] synonym: "NAD(P)H-dependent alkenal/one oxidoreductase activity" EXACT [EC:1.3.1.74] xref: EC:1.3.1.74 is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0032441 name: pheophorbide a oxygenase activity namespace: molecular_function def: "Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O." [PMID:14657372, PMID:16448336] xref: EC:1.14.15.17 xref: MetaCyc:RXN-7740 xref: RHEA:48140 is_a: GO:0016730 ! oxidoreductase activity, acting on iron-sulfur proteins as donors [Term] id: GO:0032442 name: phenylcoumaran benzylic ether reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+." [PMID:11030549, PMID:13129921] synonym: "PCBER activity" EXACT [] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0032443 name: regulation of ergosterol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol." [GOC:mah] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0106118 ! regulation of sterol biosynthetic process is_a: GO:1902930 ! regulation of alcohol biosynthetic process relationship: regulates GO:0006696 ! ergosterol biosynthetic process [Term] id: GO:0032444 name: activin responsive factor complex namespace: cellular_component def: "A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor." [PMID:12374795, PMID:9288972] comment: Note that this term should not be confused with any of the molecular function and biological process terms that refer to the small GTPase ARF (ADP-ribosylation factor). synonym: "ARF complex" EXACT [] is_a: GO:0090575 ! RNA polymerase II transcription factor complex [Term] id: GO:0032445 name: fructose import namespace: biological_process def: "The directed movement of the hexose monosaccharide fructose into a cell or organelle." [GOC:mah] synonym: "fructose uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0015755 ! fructose transmembrane transport [Term] id: GO:0032446 name: protein modification by small protein conjugation namespace: biological_process def: "A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein." [GOC:mah] is_a: GO:0070647 ! protein modification by small protein conjugation or removal [Term] id: GO:0032447 name: protein urmylation namespace: biological_process def: "Covalent attachment of the ubiquitin-like protein URM1 to another protein." [GOC:vw] is_a: GO:0032446 ! protein modification by small protein conjugation [Term] id: GO:0032448 name: DNA hairpin binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences." [GOC:mah, ISBN:0198506732] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0032449 name: CBM complex namespace: cellular_component def: "A protein complex comprising Carma1, Bcl10 and MALT1; plays a role in signal transduction during NF-kappaB activation." [PMID:12909454] synonym: "CARMA1-BCL10-Malt1 complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032450 name: maltose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-maltose + H2O = 2 alpha-D-glucose." [MetaCyc:RXN-2141] synonym: "maltase activity" EXACT [] xref: EC:3.2.1.20 xref: MetaCyc:RXN-2141 is_a: GO:0090599 ! alpha-glucosidase activity [Term] id: GO:0032451 name: demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a substrate." [GOC:mah] subset: goslim_pir is_a: GO:0003824 ! catalytic activity [Term] id: GO:0032452 name: histone demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from a histone." [GOC:mah] xref: reactome:R-HSA-3214912 "KDM1A, KDM1B demethylate MeK5-histone H3" xref: reactome:R-HSA-4722133 "KDM2A, KDM2B, KDM4A demethylate MeK37-histone H3" xref: reactome:R-HSA-4724279 "KDM4A, KDM4B, KDM4C, KDM4D demethylate Me2K10-histone H3" xref: reactome:R-HSA-4724284 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate MeK10-histone H3" xref: reactome:R-HSA-4754176 "JMJD6 demethylates MeR3-histone H3" xref: reactome:R-HSA-4754181 "KDM5A-D demethylate Me2K5-histone H3" xref: reactome:R-HSA-4754187 "KDM6A, KDM6B, KDM7A demethylate Me2K28-histone H3" xref: reactome:R-HSA-5423117 "PHF8 demethylates MeK21-histone H4" xref: reactome:R-HSA-5625797 "KDM4C demethylates Me3K-10-H3 associated with KLK2 and KLK3 promoters" xref: reactome:R-HSA-5625848 "KDM1A demethylates dimethylated H3K9 (Me2K-10-H3) at KLK2 and KLK3 promoters" xref: reactome:R-HSA-5625870 "KDM1A demethylates monomethylated H3K9 (MeK-10-H3) at KLK2 and KLK3 promoters" xref: reactome:R-HSA-5661114 "KDM2A, KDM2B, KDM4A, KDM8 demethylate Me2K37-histone H3" xref: reactome:R-HSA-5661115 "KDM3A, KDM3B, KDM7A, PHF2:ARID5B, PHF8 demethylate Me2K10-histone H3" xref: reactome:R-HSA-5661116 "KDM5A-D demethylate Me3K5-histone H3" xref: reactome:R-HSA-5661120 "KDM4A, KDM4B, KDM4C, KDM4D, MINA demethylate Me3K10-histone H3" xref: reactome:R-HSA-5661121 "KDM6A, KDM6B, KDM7A demethylate Me3K28-histone H3" xref: reactome:R-HSA-5661122 "JMJD6 demethylates Me2R3-histone H3" xref: reactome:R-HSA-5661123 "KDM1A, KDM1B demethylate Me2K5-histone H3" xref: reactome:R-HSA-5661124 "JMJD6 demethylates MeR4-HIST1H4" xref: reactome:R-HSA-5661125 "JMJD6 demethylates Me2sR4-HIST1H4" is_a: GO:0032451 ! demethylase activity is_a: GO:0140096 ! catalytic activity, acting on a protein [Term] id: GO:0032453 name: histone demethylase activity (H3-K4 specific) namespace: molecular_function def: "Catalysis of the removal of a methyl group from lysine at position 4 of the histone H3 protein." [GOC:mah] is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0032454 name: histone demethylase activity (H3-K9 specific) namespace: molecular_function def: "Catalysis of the reaction: histone H3 N6-methyl-L-lysine (position 9) + alpha-ketoglutarate + O2 = succinate + CO2 + formaldehyde + lysine. This reaction is the removal of a methyl group from lysine at position 9 of the histone H3 protein." [PMID:16362057] xref: reactome:R-HSA-9011949 "KDM4B demethylates H3K9me3 on estrogen-responsive target enhancers" xref: reactome:R-HSA-9011985 "KDM1A demethylates H3 on MYC and BCL genes in response to estrogen" xref: reactome:R-HSA-997263 "JMJD1C demethylates H3K9 mono- and di-methylation" is_a: GO:0032452 ! histone demethylase activity [Term] id: GO:0032455 name: nerve growth factor processing namespace: biological_process def: "The generation of a mature nerve growth factor (NGF) by proteolysis of a precursor." [GOC:mah, PMID:8615794] synonym: "beta-nerve growth factor processing" EXACT [PR:000011194] synonym: "NGF processing" EXACT [PR:000011194] is_a: GO:0016486 ! peptide hormone processing [Term] id: GO:0032456 name: endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from recycling endosomes back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "retrograde transport of endocytic vesicles" RELATED [] is_a: GO:0016197 ! endosomal transport [Term] id: GO:0032457 name: fast endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] synonym: "direct endocytic recycling" EXACT [] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032458 name: slow endocytic recycling namespace: biological_process def: "The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport." [GOC:ecd, PMID:16473635] is_a: GO:0032456 ! endocytic recycling [Term] id: GO:0032459 name: regulation of protein oligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein oligomerization." [GOC:mah] is_a: GO:0043254 ! regulation of protein complex assembly relationship: regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032460 name: negative regulation of protein oligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization." [GOC:mah] synonym: "down regulation of protein oligomerization" EXACT [] synonym: "down-regulation of protein oligomerization" EXACT [] synonym: "downregulation of protein oligomerization" EXACT [] synonym: "inhibition of protein oligomerization" NARROW [] is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0032459 ! regulation of protein oligomerization relationship: negatively_regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032461 name: positive regulation of protein oligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein oligomerization." [GOC:mah] synonym: "activation of protein oligomerization" NARROW [] synonym: "induction of protein oligomerization" RELATED [] synonym: "stimulation of protein oligomerization" NARROW [] synonym: "up regulation of protein oligomerization" EXACT [] synonym: "up-regulation of protein oligomerization" EXACT [] synonym: "upregulation of protein oligomerization" EXACT [] is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0032459 ! regulation of protein oligomerization relationship: positively_regulates GO:0051259 ! protein complex oligomerization [Term] id: GO:0032462 name: regulation of protein homooligomerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of protein homooligomerization." [GOC:mah] is_a: GO:0032459 ! regulation of protein oligomerization relationship: regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032463 name: negative regulation of protein homooligomerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization." [GOC:mah] synonym: "down regulation of protein homooligomerization" EXACT [] synonym: "down-regulation of protein homooligomerization" EXACT [] synonym: "downregulation of protein homooligomerization" EXACT [] synonym: "inhibition of protein homooligomerization" NARROW [] is_a: GO:0032460 ! negative regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization relationship: negatively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032464 name: positive regulation of protein homooligomerization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of protein homooligomerization." [GOC:mah] synonym: "activation of protein homooligomerization" NARROW [] synonym: "induction of protein homooligomerization" RELATED [] synonym: "stimulation of protein homooligomerization" NARROW [] synonym: "up regulation of protein homooligomerization" EXACT [] synonym: "up-regulation of protein homooligomerization" EXACT [] synonym: "upregulation of protein homooligomerization" EXACT [] is_a: GO:0032461 ! positive regulation of protein oligomerization is_a: GO:0032462 ! regulation of protein homooligomerization relationship: positively_regulates GO:0051260 ! protein homooligomerization [Term] id: GO:0032465 name: regulation of cytokinesis namespace: biological_process alt_id: GO:0071775 def: "Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells." [GOC:mah] synonym: "regulation of cell cycle cytokinesis" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051302 ! regulation of cell division relationship: regulates GO:0000910 ! cytokinesis [Term] id: GO:0032466 name: negative regulation of cytokinesis namespace: biological_process alt_id: GO:0071776 def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "down regulation of cytokinesis" EXACT [] synonym: "down-regulation of cytokinesis" EXACT [] synonym: "downregulation of cytokinesis" EXACT [] synonym: "inhibition of cytokinesis" NARROW [] synonym: "negative regulation of cell cycle cytokinesis" RELATED [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051782 ! negative regulation of cell division relationship: negatively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032467 name: positive regulation of cytokinesis namespace: biological_process alt_id: GO:0071777 def: "Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells." [GOC:mah] synonym: "activation of cytokinesis" NARROW [] synonym: "positive regulation of cell cycle cytokinesis" RELATED [] synonym: "stimulation of cytokinesis" NARROW [] synonym: "up regulation of cytokinesis" EXACT [] synonym: "up-regulation of cytokinesis" EXACT [] synonym: "upregulation of cytokinesis" EXACT [] is_a: GO:0032465 ! regulation of cytokinesis is_a: GO:0051781 ! positive regulation of cell division is_a: GO:0090068 ! positive regulation of cell cycle process relationship: positively_regulates GO:0000910 ! cytokinesis [Term] id: GO:0032468 name: Golgi calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in Golgi" EXACT [] synonym: "Golgi calcium ion concentration regulation" EXACT [] synonym: "regulation of calcium ion concentration in Golgi" EXACT [] synonym: "regulation of Golgi calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0032469 name: endoplasmic reticulum calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings." [GOC:mah] synonym: "calcium ion homeostasis in endoplasmic reticulum" EXACT [] synonym: "calcium ion homeostasis in ER" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion concentration regulation" EXACT [] synonym: "ER calcium ion homeostasis" EXACT [] synonym: "regulation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "regulation of calcium ion concentration in ER" EXACT [] synonym: "regulation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "regulation of ER calcium ion concentration" EXACT [] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0032470 name: positive regulation of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "elevation of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "elevation of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "elevation of ER calcium ion concentration" EXACT [] synonym: "endoplasmic reticulum calcium ion concentration elevation" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032471 name: negative regulation of endoplasmic reticulum calcium ion concentration namespace: biological_process def: "Any process that decreases the concentration of calcium ions in the endoplasmic reticulum." [GOC:mah] synonym: "endoplasmic reticulum calcium ion concentration reduction" EXACT [] synonym: "ER calcium ion concentration reduction" EXACT [] synonym: "reduction of calcium ion concentration in endoplasmic reticulum" EXACT [] synonym: "reduction of calcium ion concentration in ER" EXACT [] synonym: "reduction of endoplasmic reticulum calcium ion concentration" EXACT [] synonym: "reduction of ER calcium ion concentration" EXACT [] is_a: GO:0032469 ! endoplasmic reticulum calcium ion homeostasis [Term] id: GO:0032472 name: Golgi calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within the Golgi apparatus." [GOC:mah] synonym: "Golgi calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0032473 name: cytoplasmic side of mitochondrial outer membrane namespace: cellular_component def: "The external (cytoplasmic) face of the mitochondrial outer membrane." [GOC:mah] comment: In GO, 'external side' still refers to part of the membrane and does not refer to components beyond (outside of) the membrane. synonym: "cytosolic side of mitochondrial outer membrane" EXACT [] synonym: "external leaflet of mitochondrial outer membrane" EXACT [GOC:ab] synonym: "external side of mitochondrial envelope" RELATED [] synonym: "external side of mitochondrial outer membrane" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0098562 ! cytoplasmic side of membrane relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0032474 name: otolith morphogenesis namespace: biological_process def: "The process in which the anatomical structures of an otolith are generated and organized." [GOC:dgh] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0048840 ! otolith development [Term] id: GO:0032475 name: otolith formation namespace: biological_process def: "The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts." [GOC:dgh] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0032474 ! otolith morphogenesis [Term] id: GO:0032476 name: decaprenyl diphosphate synthase complex namespace: cellular_component def: "A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [GOC:mah, PMID:14519123] subset: goslim_pir is_a: GO:1990234 ! transferase complex [Term] id: GO:0032477 name: homodimeric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0032478 name: heterotetrameric decaprenyl diphosphate synthase complex namespace: cellular_component def: "A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1." [PMID:14519123] is_a: GO:0032476 ! decaprenyl diphosphate synthase complex is_a: GO:0098800 ! inner mitochondrial membrane protein complex [Term] id: GO:0032479 name: regulation of type I interferon production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "regulation of type I IFN production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032606 ! type I interferon production [Term] id: GO:0032480 name: negative regulation of type I interferon production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "down regulation of type I interferon production" EXACT [] synonym: "down-regulation of type I interferon production" EXACT [] synonym: "downregulation of type I interferon production" EXACT [] synonym: "inhibition of type I interferon production" NARROW [] synonym: "negative regulation of type I IFN production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production relationship: negatively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032481 name: positive regulation of type I interferon production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, GOC:mah] synonym: "activation of type I interferon production" NARROW [] synonym: "positive regulation of type I IFN production" EXACT [] synonym: "stimulation of type I interferon production" NARROW [] synonym: "up regulation of type I interferon production" EXACT [] synonym: "up-regulation of type I interferon production" EXACT [] synonym: "upregulation of type I interferon production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032479 ! regulation of type I interferon production relationship: positively_regulates GO:0032606 ! type I interferon production [Term] id: GO:0032482 name: Rab protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032483 name: regulation of Rab protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rab protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032482 ! Rab protein signal transduction [Term] id: GO:0032484 name: Ral protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032485 name: regulation of Ral protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Ral protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032484 ! Ral protein signal transduction [Term] id: GO:0032486 name: Rap protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state." [GOC:mah] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0032487 name: regulation of Rap protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Rap protein signal transduction." [GOC:mah] is_a: GO:0046578 ! regulation of Ras protein signal transduction relationship: regulates GO:0032486 ! Rap protein signal transduction [Term] id: GO:0032488 name: Cdc42 protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state." [GOC:mah, PMID:18558478] synonym: "Cdc42 signaling" RELATED [GOC:vw] synonym: "Cdc42 signaling pathway" RELATED [GOC:vw] synonym: "cdc42 signalling pathway" RELATED [GOC:vw] is_a: GO:0007266 ! Rho protein signal transduction [Term] id: GO:0032489 name: regulation of Cdc42 protein signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of Cdc42 protein signal transduction." [GOC:mah] is_a: GO:0035023 ! regulation of Rho protein signal transduction relationship: regulates GO:0032488 ! Cdc42 protein signal transduction [Term] id: GO:0032490 name: detection of molecule of bacterial origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal." [GOC:add, GOC:rl] synonym: "detection of bacteria associated molecule" EXACT [] synonym: "detection of bacterial associated molecule" EXACT [] synonym: "detection of bacterium associated molecule" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032491 name: detection of molecule of fungal origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of fungal associated molecule" EXACT [] synonym: "detection of fungus associated molecule" EXACT [] is_a: GO:0002238 ! response to molecule of fungal origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032492 name: detection of molecule of oomycetes origin namespace: biological_process def: "The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal." [GOC:mah, GOC:rl] synonym: "detection of oomycetes associated molecule" EXACT [] is_a: GO:0002240 ! response to molecule of oomycetes origin is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0098581 ! detection of external biotic stimulus [Term] id: GO:0032493 name: response to bacterial lipoprotein namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus." [GOC:add, PMID:12077222] is_a: GO:0002237 ! response to molecule of bacterial origin [Term] id: GO:0032494 name: response to peptidoglycan namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0010243 ! response to organonitrogen compound is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032495 name: response to muramyl dipeptide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan." [GOC:add] is_a: GO:0042493 ! response to drug is_a: GO:1901652 ! response to peptide [Term] id: GO:0032496 name: response to lipopolysaccharide namespace: biological_process def: "Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, ISBN:0721601464] synonym: "response to endotoxin" BROAD [GOC:sl] synonym: "response to LPS" EXACT [] is_a: GO:0002237 ! response to molecule of bacterial origin is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032497 name: detection of lipopolysaccharide namespace: biological_process def: "The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria." [GOC:add, PMID:15998797] synonym: "detection of LPS" EXACT [] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032496 ! response to lipopolysaccharide [Term] id: GO:0032498 name: detection of muramyl dipeptide namespace: biological_process def: "The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan." [GOC:rl, PMID:15998797] is_a: GO:0032495 ! response to muramyl dipeptide is_a: GO:0032499 ! detection of peptidoglycan [Term] id: GO:0032499 name: detection of peptidoglycan namespace: biological_process def: "The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule." [GOC:add, ISBN:0721601464] is_a: GO:0032490 ! detection of molecule of bacterial origin is_a: GO:0032494 ! response to peptidoglycan [Term] id: GO:0032500 name: muramyl dipeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan." [GOC:rl] is_a: GO:0008144 ! drug binding is_a: GO:0042277 ! peptide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032501 name: multicellular organismal process namespace: biological_process alt_id: GO:0044707 alt_id: GO:0050874 def: "Any biological process, occurring at the level of a multicellular organism, pertinent to its function." [GOC:curators, GOC:dph, GOC:isa_complete, GOC:tb] subset: goslim_pir synonym: "organismal physiological process" EXACT [] synonym: "single-multicellular organism process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0032502 name: developmental process namespace: biological_process alt_id: GO:0044767 def: "A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition." [GOC:isa_complete] subset: goslim_agr subset: goslim_aspergillus subset: goslim_flybase_ribbon subset: goslim_pir synonym: "development" NARROW [] synonym: "single-organism developmental process" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0032504 name: multicellular organism reproduction namespace: biological_process def: "The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete, GOC:jid] is_a: GO:0000003 ! reproduction is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032505 name: reproduction of a single-celled organism namespace: biological_process def: "The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents." [GOC:isa_complete] is_a: GO:0000003 ! reproduction [Term] id: GO:0032506 name: cytokinetic process namespace: biological_process def: "A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells)." [GOC:bf, GOC:isa_complete, GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000910 ! cytokinesis [Term] id: GO:0032507 name: maintenance of protein location in cell namespace: biological_process def: "Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere." [GOC:isa_complete, GOC:mah] synonym: "maintenance of protein localization in cell" RELATED [GOC:dph, GOC:tb] is_a: GO:0045185 ! maintenance of protein location is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0032508 name: DNA duplex unwinding namespace: biological_process def: "The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands." [GOC:isa_complete, GOC:mah] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. synonym: "DNA unwinding" EXACT [] synonym: "duplex DNA melting" EXACT [] is_a: GO:0032392 ! DNA geometric change [Term] id: GO:0032509 name: endosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome transport via MVB sorting pathway" EXACT [] is_a: GO:0016197 ! endosomal transport is_a: GO:0071985 ! multivesicular body sorting pathway [Term] id: GO:0032510 name: endosome to lysosome transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to lysosome transport via MVB sorting pathway" EXACT [] is_a: GO:0008333 ! endosome to lysosome transport is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway [Term] id: GO:0032511 name: late endosome to vacuole transport via multivesicular body sorting pathway namespace: biological_process def: "The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole." [GOC:mah, PMID:12461556, PMID:16689637] synonym: "endosome to vacuole transport via MVB sorting pathway" EXACT [] is_a: GO:0032509 ! endosome transport via multivesicular body sorting pathway is_a: GO:0045324 ! late endosome to vacuole transport [Term] id: GO:0032515 name: negative regulation of phosphoprotein phosphatase activity namespace: biological_process alt_id: GO:0032513 alt_id: GO:0034048 def: "Any process that stops or reduces the activity of a phosphoprotein phosphatase." [GOC:mah] synonym: "down regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "down regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "down regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "down regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "down regulation of protein phosphatase type 2A activity" NARROW [] synonym: "down regulation of protein phosphatase type 2B activity" NARROW [] synonym: "down-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "down-regulation of protein phosphatase type 2A activity" NARROW [] synonym: "down-regulation of protein phosphatase type 2B activity" NARROW [] synonym: "downregulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "downregulation of phosphoprotein phosphatase activity" EXACT [] synonym: "downregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "downregulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "downregulation of protein phosphatase type 2A activity" NARROW [] synonym: "downregulation of protein phosphatase type 2B activity" NARROW [] synonym: "inhibition of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "inhibition of phosphoprotein phosphatase activity" NARROW [] synonym: "inhibition of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "inhibition of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "inhibition of protein phosphatase type 2A activity" NARROW [] synonym: "inhibition of protein phosphatase type 2B activity" NARROW [] synonym: "negative regulation of calcineurin activity" NARROW [] synonym: "negative regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "negative regulation of protein phosphatase type 2A activity" NARROW [] synonym: "negative regulation of protein phosphatase type 2B activity" NARROW [] synonym: "regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] is_a: GO:0010923 ! negative regulation of phosphatase activity is_a: GO:0035308 ! negative regulation of protein dephosphorylation is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0032516 name: positive regulation of phosphoprotein phosphatase activity namespace: biological_process alt_id: GO:0032514 alt_id: GO:0034049 def: "Any process that activates or increases the activity of a phosphoprotein phosphatase." [GOC:mah] synonym: "activation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "activation of phosphoprotein phosphatase activity" NARROW [] synonym: "activation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "activation of protein phosphatase type 2A activity" NARROW [] synonym: "activation of protein phosphatase type 2B activity" NARROW [] synonym: "calcineurin activation" NARROW [] synonym: "positive regulation of calcineurin activity" NARROW [] synonym: "positive regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "positive regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "positive regulation of protein phosphatase type 2A activity" NARROW [] synonym: "positive regulation of protein phosphatase type 2B activity" NARROW [] synonym: "stimulation of phosphoprotein phosphatase activity" NARROW [] synonym: "stimulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "stimulation of protein phosphatase type 2A activity" NARROW [] synonym: "stimulation of protein phosphatase type 2B activity" NARROW [] synonym: "up regulation of calcineurin activity" NARROW [GOC:dph, GOC:rl] synonym: "up regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "up regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "up regulation of protein phosphatase 3 activity" RELATED [GOC:dph, GOC:rl] synonym: "up regulation of protein phosphatase type 2A activity" NARROW [] synonym: "up regulation of protein phosphatase type 2B activity" NARROW [] synonym: "up-regulation of phosphoprotein phosphatase activity" EXACT [] synonym: "up-regulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "up-regulation of protein phosphatase type 2A activity" NARROW [] synonym: "up-regulation of protein phosphatase type 2B activity" NARROW [] synonym: "upregulation of phosphoprotein phosphatase activity" EXACT [] synonym: "upregulation of protein phosphatase 2 activity" RELATED [GOC:dph, GOC:rl] synonym: "upregulation of protein phosphatase type 2A activity" NARROW [] synonym: "upregulation of protein phosphatase type 2B activity" NARROW [] is_a: GO:0010922 ! positive regulation of phosphatase activity is_a: GO:0035307 ! positive regulation of protein dephosphorylation is_a: GO:0043666 ! regulation of phosphoprotein phosphatase activity [Term] id: GO:0032517 name: SOD1-calcineurin complex namespace: cellular_component def: "A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1." [GOC:mah, PMID:17324120] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032518 name: amino acid-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(in) -> ADP + phosphate + amino acid(out)." [GOC:mah] is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0032519 name: cysteine-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cysteine(in) -> ADP + phosphate + cysteine(out)." [GOC:mah] synonym: "cysteine exporter" RELATED [] is_a: GO:0032518 ! amino acid-exporting ATPase activity is_a: GO:0033230 ! cysteine-transporting ATPase activity [Term] id: GO:0032520 name: amino acid-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + amino acid(out) -> ADP + phosphate + amino acid(in)." [GOC:mah] is_a: GO:0015424 ! amino acid-transporting ATPase activity [Term] id: GO:0032521 name: D-methionine-exporting ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(in) -> ADP + phosphate + D-methionine(out)." [GOC:mah] synonym: "D-methionine exporter" RELATED [] is_a: GO:0032518 ! amino acid-exporting ATPase activity is_a: GO:0033232 ! D-methionine-transporting ATPase activity [Term] id: GO:0032522 name: D-methionine-importing ATPase activity namespace: molecular_function def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + D-methionine(out) -> ADP + phosphate + D-methionine(in)." [GOC:mah] synonym: "D-methionine importer" RELATED [] is_a: GO:0032520 ! amino acid-importing ATPase activity is_a: GO:0033232 ! D-methionine-transporting ATPase activity [Term] id: GO:0032523 name: silicon efflux transmembrane transporter activity namespace: molecular_function def: "Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane." [GOC:mah, PMID:17625566] synonym: "silicon efflux transporter activity" EXACT [] is_a: GO:0008324 ! cation transmembrane transporter activity is_a: GO:0015562 ! efflux transmembrane transporter activity [Term] id: GO:0032524 name: obsolete nutrient export namespace: biological_process def: "OBSOLETE. The directed movement of nutrients out of a cell or organelle." [GOC:mah] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. synonym: "nutrient export" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0032525 name: somite rostral/caudal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary." [GOC:bf, PMID:16326386, PMID:17360776] synonym: "somite rostrocaudal axis specification" EXACT [] synonym: "somite rostrocaudal polarity" RELATED [] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0032526 name: response to retinoic acid namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus." [GOC:sl] synonym: "response to vitamin A acid" EXACT [] is_a: GO:0001101 ! response to acid chemical is_a: GO:0033993 ! response to lipid is_a: GO:1901700 ! response to oxygen-containing compound [Term] id: GO:0032527 name: protein exit from endoplasmic reticulum namespace: biological_process def: "The directed movement of proteins from the endoplasmic reticulum." [GOC:rb] synonym: "protein exit from ER" EXACT [] synonym: "protein export from endoplasmic reticulum" EXACT [GOC:mah] synonym: "protein export from ER" EXACT [GOC:mah] is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0032528 name: microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell." [GOC:mah] synonym: "microvillus organisation" EXACT [GOC:mah] synonym: "microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0032529 name: follicle cell microvillus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments." [GOC:sart, PMID:16507588] synonym: "follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032528 ! microvillus organization [Term] id: GO:0032530 name: regulation of microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus." [GOC:mah] synonym: "regulation of microvillus organisation" EXACT [GOC:mah] synonym: "regulation of microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120035 ! regulation of plasma membrane bounded cell projection organization relationship: regulates GO:0032528 ! microvillus organization [Term] id: GO:0032531 name: regulation of follicle cell microvillus organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell." [GOC:mah] synonym: "regulation of follicle cell microvillus organisation" EXACT [GOC:mah] synonym: "regulation of follicle cell microvillus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization relationship: regulates GO:0032529 ! follicle cell microvillus organization [Term] id: GO:0032532 name: regulation of microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus." [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0032536 ! regulation of cell projection size [Term] id: GO:0032533 name: regulation of follicle cell microvillus length namespace: biological_process def: "A process that modulates the length of a microvillus on a follicle cell." [GOC:sart, PMID:16260500] is_a: GO:0008361 ! regulation of cell size is_a: GO:0032531 ! regulation of follicle cell microvillus organization is_a: GO:0032532 ! regulation of microvillus length [Term] id: GO:0032534 name: regulation of microvillus assembly namespace: biological_process def: "A process that modulates the formation of a microvillus." [GOC:mah] synonym: "regulation of microvillus biogenesis" RELATED [GOC:mah] is_a: GO:0032530 ! regulation of microvillus organization is_a: GO:0120032 ! regulation of plasma membrane bounded cell projection assembly relationship: regulates GO:0030033 ! microvillus assembly [Term] id: GO:0032535 name: regulation of cellular component size namespace: biological_process def: "A process that modulates the size of a cellular component." [GOC:mah] is_a: GO:0016043 ! cellular component organization is_a: GO:0090066 ! regulation of anatomical structure size [Term] id: GO:0032536 name: regulation of cell projection size namespace: biological_process def: "A process that modulates the size of a cell projection." [GOC:mah] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0032537 name: host-seeking behavior namespace: biological_process def: "The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host." [GOC:mah, GOC:pr, PMID:11931033] synonym: "host-seeking behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0032538 name: regulation of host-seeking behavior namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "regulation of host-seeking behaviour" EXACT [] is_a: GO:0050795 ! regulation of behavior relationship: regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032539 name: negative regulation of host-seeking behavior namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "down regulation of host-seeking behavior" EXACT [] synonym: "down-regulation of host-seeking behavior" EXACT [] synonym: "downregulation of host-seeking behavior" EXACT [] synonym: "inhibition of host-seeking behavior" NARROW [] synonym: "negative regulation of host-seeking behaviour" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048521 ! negative regulation of behavior relationship: negatively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032540 name: positive regulation of host-seeking behavior namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism." [GOC:mah] synonym: "activation of host-seeking behavior" NARROW [] synonym: "positive regulation of host-seeking behaviour" EXACT [] synonym: "stimulation of host-seeking behavior" NARROW [] synonym: "up regulation of host-seeking behavior" EXACT [] synonym: "up-regulation of host-seeking behavior" EXACT [] synonym: "upregulation of host-seeking behavior" EXACT [] is_a: GO:0032538 ! regulation of host-seeking behavior is_a: GO:0048520 ! positive regulation of behavior relationship: positively_regulates GO:0032537 ! host-seeking behavior [Term] id: GO:0032541 name: cortical endoplasmic reticulum namespace: cellular_component def: "A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements." [GOC:se, PMID:10931860, PMID:17686782] comment: The dynamic nature of the cortical ER and the movements it undergoes (branching and ring closure) has been shown in both yeast and mammalian cells, so appears highly conserved. (PMID:10931860) synonym: "cortical ER" EXACT [] synonym: "ER-PM peripheral junction" BROAD [GOC:ans, PMID:21062895] synonym: "peripheral endoplasmic reticulum" RELATED [] synonym: "peripheral ER" RELATED [] is_a: GO:0044448 ! cell cortex part is_a: GO:0071782 ! endoplasmic reticulum tubular network [Term] id: GO:0032542 name: sulfiredoxin activity namespace: molecular_function def: "Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R." [EC:1.8.98.2, PMID:16102934] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine) reductase activity" EXACT [] synonym: "peroxiredoxin-(S-hydroxy-S-oxocysteine):thiol oxidoreductase [ATP-hydrolysing; peroxiredoxin-(S-hydroxycysteine)-forming]" RELATED [EC:1.8.98.2] synonym: "Srx1" RELATED [EC:1.8.98.2] synonym: "sulphiredoxin activity" EXACT [] xref: EC:1.8.98.2 xref: MetaCyc:1.8.98.2-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016667 ! oxidoreductase activity, acting on a sulfur group of donors [Term] id: GO:0032543 name: mitochondrial translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] subset: goslim_yeast synonym: "mitochondrial protein anabolism" EXACT [] synonym: "mitochondrial protein biosynthesis" EXACT [] synonym: "mitochondrial protein formation" EXACT [] synonym: "mitochondrial protein synthesis" EXACT [] synonym: "mitochondrial protein translation" EXACT [] is_a: GO:0006412 ! translation relationship: part_of GO:0140053 ! mitochondrial gene expression [Term] id: GO:0032544 name: plastid translation namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code." [GOC:go_curators] synonym: "plastid protein anabolism" EXACT [] synonym: "plastid protein biosynthesis" EXACT [] synonym: "plastid protein formation" EXACT [] synonym: "plastid protein synthesis" EXACT [] synonym: "plastid protein translation" EXACT [] is_a: GO:0006412 ! translation is_a: GO:0009657 ! plastid organization [Term] id: GO:0032545 name: CURI complex namespace: cellular_component def: "A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p." [PMID:17452446] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032546 name: deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose." [GOC:mah] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032547 name: purine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose." [GOC:mah] is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032548 name: pyrimidine deoxyribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose." [GOC:mah] is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032546 ! deoxyribonucleoside binding [Term] id: GO:0032549 name: ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose." [GOC:mah] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0032550 name: purine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleoside, a compound consisting of a purine base linked to ribose." [GOC:mah] is_a: GO:0001883 ! purine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032551 name: pyrimidine ribonucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose." [GOC:mah] is_a: GO:0001884 ! pyrimidine nucleoside binding is_a: GO:0032549 ! ribonucleoside binding [Term] id: GO:0032552 name: deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032553 name: ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0000166 ! nucleotide binding is_a: GO:0097367 ! carbohydrate derivative binding [Term] id: GO:0032554 name: purine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032555 name: purine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0017076 ! purine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032556 name: pyrimidine deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032552 ! deoxyribonucleotide binding [Term] id: GO:0032557 name: pyrimidine ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0019103 ! pyrimidine nucleotide binding is_a: GO:0032553 ! ribonucleotide binding [Term] id: GO:0032558 name: adenyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding [Term] id: GO:0032559 name: adenyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032560 name: guanyl deoxyribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety." [GOC:mah] is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032554 ! purine deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032561 name: guanyl ribonucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety." [GOC:mah] is_a: GO:0019001 ! guanyl nucleotide binding is_a: GO:0032555 ! purine ribonucleotide binding [Term] id: GO:0032562 name: dAMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dAMP, deoxyadenosine monophosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032563 name: dADP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dADP, deoxyadenosine diphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032564 name: dATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dATP, deoxyadenosine triphosphate." [GOC:mah] is_a: GO:0032558 ! adenyl deoxyribonucleotide binding is_a: GO:0043168 ! anion binding [Term] id: GO:0032565 name: dGMP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGMP, deoxyguanosine monophosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032566 name: dGDP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGDP, deoxyguanosine diphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032567 name: dGTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with dGTP, deoxyguanosine triphosphate." [GOC:mah] is_a: GO:0032560 ! guanyl deoxyribonucleotide binding [Term] id: GO:0032570 name: response to progesterone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus." [GOC:sl] synonym: "response to progesterone stimulus" EXACT [GOC:dos] is_a: GO:0042493 ! response to drug is_a: GO:0048545 ! response to steroid hormone is_a: GO:1901654 ! response to ketone [Term] id: GO:0032571 name: response to vitamin K namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus." [GOC:sl] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0032572 name: response to menaquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus." [GOC:sl] synonym: "response to menatetrenone" EXACT [] synonym: "response to vitamin K2" EXACT [] is_a: GO:1901654 ! response to ketone [Term] id: GO:0032573 name: response to phylloquinone namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus." [GOC:sl] synonym: "response to vitamin K1" EXACT [] is_a: GO:0033273 ! response to vitamin is_a: GO:1901654 ! response to ketone [Term] id: GO:0032574 name: 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "5' to 3' RNA helicase activity" EXACT [] is_a: GO:0003724 ! RNA helicase activity [Term] id: GO:0032575 name: ATP-dependent 5'-3' RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate; this reaction drives the unwinding of an RNA helix in the direction 5' to 3'." [GOC:jp] synonym: "ATP-dependent 5' to 3' RNA helicase activity" EXACT [] is_a: GO:0004004 ! ATP-dependent RNA helicase activity is_a: GO:0032574 ! 5'-3' RNA helicase activity [Term] id: GO:0032576 name: O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule." [GOC:cb] is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0032577 name: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule." [GOC:cb, GOC:mah] synonym: "phosphatidylcholine:cardiolipin linoleoyltransferase" EXACT [] is_a: GO:0032576 ! O-linoleoyltransferase activity [Term] id: GO:0032578 name: aleurone grain membrane namespace: cellular_component def: "The lipid bilayer surrounding an aleurone grain." [GOC:ecd] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0033095 ! aleurone grain [Term] id: GO:0032579 name: apical lamina of hyaline layer namespace: cellular_component def: "A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms." [GOC:ecd, PMID:2060714, PMID:7608987, PMID:9638331] is_a: GO:0044420 ! extracellular matrix component relationship: part_of GO:0033166 ! hyaline layer [Term] id: GO:0032580 name: Golgi cisterna membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex." [GOC:ecd, GOC:mah] synonym: "Golgi stack membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0031985 ! Golgi cisterna [Term] id: GO:0032581 name: ER-dependent peroxisome organization namespace: biological_process def: "A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum." [GOC:mah, PMID:16717127, PMID:17646399] synonym: "endoplasmic reticulum-dependent peroxisome organization" EXACT [GOC:mah] synonym: "ER-dependent peroxisome biogenesis" RELATED [GOC:mah] synonym: "ER-dependent peroxisome organisation" EXACT [GOC:mah] is_a: GO:0007031 ! peroxisome organization [Term] id: GO:0032584 name: growth cone membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a growth cone." [GOC:mah] is_a: GO:0044459 ! plasma membrane part is_a: GO:0090723 ! growth cone part [Term] id: GO:0032585 name: multivesicular body membrane namespace: cellular_component def: "The lipid bilayer surrounding a multivesicular body." [GOC:mah] synonym: "multivesicular endosome membrane" EXACT [] synonym: "MVB membrane" EXACT [] synonym: "MVE membrane" EXACT [] is_a: GO:0031902 ! late endosome membrane relationship: part_of GO:0005771 ! multivesicular body [Term] id: GO:0032586 name: protein storage vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a protein storage vacuole." [GOC:mah] is_a: GO:0009705 ! plant-type vacuole membrane [Term] id: GO:0032587 name: ruffle membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a ruffle." [GOC:mah] synonym: "membrane ruffle" RELATED [] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane relationship: part_of GO:0001726 ! ruffle [Term] id: GO:0032588 name: trans-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the trans-Golgi network." [GOC:mah] synonym: "Golgi trans face membrane" RELATED [] synonym: "trans Golgi network membrane" EXACT [] is_a: GO:0000139 ! Golgi membrane relationship: part_of GO:0005802 ! trans-Golgi network [Term] id: GO:0032589 name: neuron projection membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a neuron projection." [GOC:mah] is_a: GO:0031253 ! cell projection membrane is_a: GO:0031256 ! leading edge membrane is_a: GO:0097458 ! neuron part relationship: part_of GO:0043005 ! neuron projection [Term] id: GO:0032590 name: dendrite membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendrite." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane [Term] id: GO:0032591 name: dendritic spine membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a dendritic spine." [GOC:mah] is_a: GO:0032589 ! neuron projection membrane is_a: GO:0097060 ! synaptic membrane relationship: part_of GO:0032590 ! dendrite membrane [Term] id: GO:0032592 name: integral component of mitochondrial membrane namespace: cellular_component def: "The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane." [GOC:dos, GOC:mah] synonym: "integral to mitochondrial membrane" NARROW [] is_a: GO:0031301 ! integral component of organelle membrane is_a: GO:0098573 ! intrinsic component of mitochondrial membrane [Term] id: GO:0032593 name: insulin-responsive compartment namespace: cellular_component def: "A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2." [PMID:17644329] synonym: "GLUT4 storage compartment" EXACT [] synonym: "GSC" RELATED [] synonym: "IRC" RELATED [] is_a: GO:0030141 ! secretory granule [Term] id: GO:0032594 name: protein transport within lipid bilayer namespace: biological_process def: "The directed movement of a protein from one location to another within a lipid bilayer." [GOC:mah] synonym: "protein translocation within membrane" EXACT [] synonym: "receptor translocation within membrane" NARROW [] synonym: "receptor transport within lipid bilayer" NARROW [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0051668 ! localization within membrane is_a: GO:0061024 ! membrane organization [Term] id: GO:0032595 name: B cell receptor transport within lipid bilayer namespace: biological_process def: "The directed movement of a B cell receptor within a lipid bilayer." [GOC:mah] synonym: "B cell receptor translocation within membrane" EXACT [] synonym: "BCR translocation within membrane" EXACT [] synonym: "BCR transport within lipid bilayer" EXACT [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032596 name: protein transport into membrane raft namespace: biological_process def: "The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "protein translocation into membrane raft" EXACT [] synonym: "protein transport into lipid raft" EXACT [] synonym: "receptor translocation into membrane raft" NARROW [] synonym: "receptor transport into membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer is_a: GO:0090150 ! establishment of protein localization to membrane is_a: GO:1903044 ! protein localization to membrane raft [Term] id: GO:0032597 name: B cell receptor transport into membrane raft namespace: biological_process def: "The directed movement of a B cell receptor into a membrane raft." [GOC:mah] synonym: "B cell receptor translocation into membrane raft" EXACT [] synonym: "B cell receptor transport into lipid raft" EXACT [] synonym: "BCR translocation into membrane raft" EXACT [] synonym: "BCR transport into membrane raft" EXACT [] is_a: GO:0032595 ! B cell receptor transport within lipid bilayer is_a: GO:0032596 ! protein transport into membrane raft [Term] id: GO:0032598 name: B cell receptor transport into immunological synapse namespace: biological_process def: "The directed movement of a B cell receptor into an immunological synapse." [GOC:mah] synonym: "B cell receptor translocation into immunological synapse" EXACT [] synonym: "BCR translocation into immunological synapse" EXACT [] synonym: "BCR transport into immunological synapse" EXACT [] is_a: GO:0032597 ! B cell receptor transport into membrane raft [Term] id: GO:0032599 name: protein transport out of membrane raft namespace: biological_process def: "The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes." [GOC:mah] synonym: "protein translocation out of membrane raft" EXACT [] synonym: "protein transport out of lipid raft" EXACT [] synonym: "receptor translocation out of membrane raft" NARROW [] synonym: "receptor transport out of membrane raft" NARROW [] is_a: GO:0032594 ! protein transport within lipid bilayer [Term] id: GO:0032600 name: chemokine receptor transport out of membrane raft namespace: biological_process def: "The directed movement of a chemokine receptor out of a membrane raft." [GOC:mah] synonym: "chemokine receptor translocation out of membrane raft" EXACT [] synonym: "chemokine receptor transport out of lipid raft" EXACT [] is_a: GO:0032599 ! protein transport out of membrane raft is_a: GO:0033606 ! chemokine receptor transport within lipid bilayer [Term] id: GO:0032601 name: connective tissue growth factor production namespace: biological_process def: "The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "CCN2 production" EXACT [] synonym: "CTGF production" EXACT [] synonym: "Fisp12 production" EXACT [] synonym: "Hcs24 production" EXACT [] synonym: "hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "IGFBP8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032602 name: chemokine production namespace: biological_process def: "The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032603 name: fractalkine production namespace: biological_process def: "The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0032602 ! chemokine production [Term] id: GO:0032604 name: granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "GM-CSF production" EXACT [GOC:vk] synonym: "granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032605 name: hepatocyte growth factor production namespace: biological_process def: "The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032606 name: type I interferon production namespace: biological_process def: "The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon type I production" EXACT [] synonym: "type I IFN production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032607 name: interferon-alpha production namespace: biological_process def: "The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-alpha production" EXACT [GOC:mah] synonym: "IFNA production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032608 name: interferon-beta production namespace: biological_process def: "The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IFN-beta production" EXACT [] synonym: "IFNB production" EXACT [GOC:mah] is_a: GO:0032606 ! type I interferon production [Term] id: GO:0032609 name: interferon-gamma production namespace: biological_process def: "The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "IFNG production" EXACT [GOC:mah] synonym: "type II IFN production" BROAD [GOC:mah] synonym: "type II interferon production" BROAD [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032610 name: interleukin-1 alpha production namespace: biological_process def: "The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 alpha production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032611 name: interleukin-1 beta production namespace: biological_process def: "The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 beta production" EXACT [] is_a: GO:0032612 ! interleukin-1 production [Term] id: GO:0032612 name: interleukin-1 production namespace: biological_process def: "The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-1 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032613 name: interleukin-10 production namespace: biological_process def: "The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-10 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032614 name: interleukin-11 production namespace: biological_process def: "The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-11 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032615 name: interleukin-12 production namespace: biological_process def: "The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-12 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032616 name: interleukin-13 production namespace: biological_process def: "The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-13 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032617 name: interleukin-14 production namespace: biological_process def: "The appearance of interleukin-14 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-14 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032618 name: interleukin-15 production namespace: biological_process def: "The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-15 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032619 name: interleukin-16 production namespace: biological_process def: "The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-16 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032620 name: interleukin-17 production namespace: biological_process def: "The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah, GOC:rv, PR:000001092, Wikipedia:Interleukin_17] synonym: "IL-17 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032621 name: interleukin-18 production namespace: biological_process def: "The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-18 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032622 name: interleukin-19 production namespace: biological_process def: "The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-19 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032623 name: interleukin-2 production namespace: biological_process def: "The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-2 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032624 name: interleukin-20 production namespace: biological_process def: "The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-20 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032625 name: interleukin-21 production namespace: biological_process def: "The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-21 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032626 name: interleukin-22 production namespace: biological_process def: "The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-22 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032627 name: interleukin-23 production namespace: biological_process def: "The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-23 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032628 name: interleukin-24 production namespace: biological_process def: "The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-24 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032629 name: interleukin-25 production namespace: biological_process def: "The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-25 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032630 name: interleukin-26 production namespace: biological_process def: "The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-26 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032631 name: interleukin-27 production namespace: biological_process def: "The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-27 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032632 name: interleukin-3 production namespace: biological_process def: "The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-3 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032633 name: interleukin-4 production namespace: biological_process def: "The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-4 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032634 name: interleukin-5 production namespace: biological_process def: "The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-5 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032635 name: interleukin-6 production namespace: biological_process def: "The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-6 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032636 name: interleukin-7 production namespace: biological_process def: "The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-7 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032637 name: interleukin-8 production namespace: biological_process def: "The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-8 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032638 name: interleukin-9 production namespace: biological_process def: "The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "IL-9 production" EXACT [] is_a: GO:0001816 ! cytokine production [Term] id: GO:0032639 name: TRAIL production namespace: biological_process def: "The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032640 name: tumor necrosis factor production namespace: biological_process def: "The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "TNF production" EXACT [] synonym: "TNF-alpha production" EXACT [] synonym: "tumor necrosis factor-alpha production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032641 name: lymphotoxin A production namespace: biological_process def: "The appearance of lymphotoxin A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "LTA production" EXACT [] synonym: "lymphotoxin-alpha production" EXACT [] synonym: "TNF-beta production" EXACT [] synonym: "tumor necrosis factor-beta production" EXACT [] is_a: GO:0071706 ! tumor necrosis factor superfamily cytokine production [Term] id: GO:0032642 name: regulation of chemokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of chemokine production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032602 ! chemokine production [Term] id: GO:0032643 name: regulation of connective tissue growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "regulation of CCN2 production" EXACT [] synonym: "regulation of CTGF production" EXACT [] synonym: "regulation of Fisp12 production" EXACT [] synonym: "regulation of Hcs24 production" EXACT [] synonym: "regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "regulation of IGFBP8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032644 name: regulation of fractalkine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of fractalkine production." [GOC:mah] is_a: GO:0032642 ! regulation of chemokine production relationship: regulates GO:0032603 ! fractalkine production [Term] id: GO:0032645 name: regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "regulation of GM-CSF production" EXACT [GOC:vk] synonym: "regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032646 name: regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032647 name: regulation of interferon-alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-alpha production." [GOC:mah] is_a: GO:0032479 ! regulation of type I interferon production relationship: regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032648 name: regulation of interferon-beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "regulation of IFN-beta production" EXACT [] is_a: GO:0032479 ! regulation of type I interferon production relationship: regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032649 name: regulation of interferon-gamma production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "regulation of type II interferon production" BROAD [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032650 name: regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "regulation of IL-1 alpha production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production relationship: regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032651 name: regulation of interleukin-1 beta production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "regulation of IL-1 beta production" EXACT [] is_a: GO:0032652 ! regulation of interleukin-1 production relationship: regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032652 name: regulation of interleukin-1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "regulation of IL-1 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032653 name: regulation of interleukin-10 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "regulation of IL-10 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032654 name: regulation of interleukin-11 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "regulation of IL-11 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032655 name: regulation of interleukin-12 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "regulation of IL-12 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032656 name: regulation of interleukin-13 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "regulation of IL-13 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032657 name: regulation of interleukin-14 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "regulation of IL-14 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032658 name: regulation of interleukin-15 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "regulation of IL-15 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032659 name: regulation of interleukin-16 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "regulation of IL-16 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032660 name: regulation of interleukin-17 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "regulation of IL-17 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032661 name: regulation of interleukin-18 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "regulation of IL-18 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032662 name: regulation of interleukin-19 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "regulation of IL-19 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032663 name: regulation of interleukin-2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "regulation of IL-2 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032664 name: regulation of interleukin-20 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "regulation of IL-20 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032665 name: regulation of interleukin-21 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "regulation of IL-21 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032666 name: regulation of interleukin-22 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "regulation of IL-22 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032667 name: regulation of interleukin-23 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "regulation of IL-23 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032668 name: regulation of interleukin-24 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "regulation of IL-24 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032669 name: regulation of interleukin-25 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "regulation of IL-25 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032670 name: regulation of interleukin-26 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "regulation of IL-26 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032671 name: regulation of interleukin-27 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "regulation of IL-27 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032672 name: regulation of interleukin-3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "regulation of IL-3 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032673 name: regulation of interleukin-4 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "regulation of IL-4 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032674 name: regulation of interleukin-5 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "regulation of IL-5 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032675 name: regulation of interleukin-6 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "regulation of IL-6 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032676 name: regulation of interleukin-7 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "regulation of IL-7 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032677 name: regulation of interleukin-8 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "regulation of IL-8 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032678 name: regulation of interleukin-9 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "regulation of IL-9 production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production relationship: regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032679 name: regulation of TRAIL production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of TRAIL production." [GOC:mah] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production relationship: regulates GO:0032639 ! TRAIL production [Term] id: GO:0032680 name: regulation of tumor necrosis factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "regulation of TNF production" EXACT [] synonym: "regulation of TNF-alpha production" EXACT [] synonym: "regulation of tumor necrosis factor-alpha production" EXACT [] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production relationship: regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032681 name: regulation of lymphotoxin A production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "regulation of LTA production" EXACT [] synonym: "regulation of lymphotoxin-alpha production" EXACT [] synonym: "regulation of TNF-beta production" EXACT [] synonym: "regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:1903555 ! regulation of tumor necrosis factor superfamily cytokine production relationship: regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032682 name: negative regulation of chemokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "down regulation of chemokine production" EXACT [] synonym: "down-regulation of chemokine production" EXACT [] synonym: "downregulation of chemokine production" EXACT [] synonym: "inhibition of chemokine production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production relationship: negatively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032683 name: negative regulation of connective tissue growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "down regulation of connective tissue growth factor production" EXACT [] synonym: "down-regulation of connective tissue growth factor production" EXACT [] synonym: "downregulation of connective tissue growth factor production" EXACT [] synonym: "inhibition of connective tissue growth factor production" NARROW [] synonym: "negative regulation of CCN2 production" EXACT [] synonym: "negative regulation of CTGF production" EXACT [] synonym: "negative regulation of Fisp12 production" EXACT [] synonym: "negative regulation of Hcs24 production" EXACT [] synonym: "negative regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "negative regulation of IGFBP8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production relationship: negatively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032684 name: negative regulation of fractalkine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "down regulation of fractalkine production" EXACT [] synonym: "down-regulation of fractalkine production" EXACT [] synonym: "downregulation of fractalkine production" EXACT [] synonym: "inhibition of fractalkine production" NARROW [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032682 ! negative regulation of chemokine production relationship: negatively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032685 name: negative regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "down regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "down-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "downregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "inhibition of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "negative regulation of GM-CSF production" EXACT [GOC:vk] synonym: "negative regulation of granulocyte macrophage colony stimulating factor production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production relationship: negatively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032686 name: negative regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "down regulation of hepatocyte growth factor production" EXACT [] synonym: "down-regulation of hepatocyte growth factor production" EXACT [] synonym: "downregulation of hepatocyte growth factor production" EXACT [] synonym: "inhibition of hepatocyte growth factor production" NARROW [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production relationship: negatively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032687 name: negative regulation of interferon-alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "down regulation of interferon-alpha production" EXACT [] synonym: "down-regulation of interferon-alpha production" EXACT [] synonym: "downregulation of interferon-alpha production" EXACT [] synonym: "inhibition of interferon-alpha production" NARROW [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production relationship: negatively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032688 name: negative regulation of interferon-beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "down regulation of interferon-beta production" EXACT [] synonym: "down-regulation of interferon-beta production" EXACT [] synonym: "downregulation of interferon-beta production" EXACT [] synonym: "inhibition of interferon-beta production" NARROW [] synonym: "negative regulation of IFN-beta production" EXACT [] is_a: GO:0032480 ! negative regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production relationship: negatively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032689 name: negative regulation of interferon-gamma production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "down regulation of interferon-gamma production" EXACT [] synonym: "down-regulation of interferon-gamma production" EXACT [] synonym: "downregulation of interferon-gamma production" EXACT [] synonym: "inhibition of interferon-gamma production" NARROW [] synonym: "negative regulation of type II interferon production" BROAD [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production relationship: negatively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032690 name: negative regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "down regulation of interleukin-1 alpha production" EXACT [] synonym: "down-regulation of interleukin-1 alpha production" EXACT [] synonym: "downregulation of interleukin-1 alpha production" EXACT [] synonym: "inhibition of interleukin-1 alpha production" NARROW [] synonym: "negative regulation of IL-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032692 ! negative regulation of interleukin-1 production relationship: negatively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032691 name: negative regulation of interleukin-1 beta production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "down regulation of interleukin-1 beta production" EXACT [] synonym: "down-regulation of interleukin-1 beta production" EXACT [] synonym: "downregulation of interleukin-1 beta production" EXACT [] synonym: "inhibition of interleukin-1 beta production" NARROW [] synonym: "negative regulation of IL-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032692 ! negative regulation of interleukin-1 production relationship: negatively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032692 name: negative regulation of interleukin-1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "down regulation of interleukin-1 production" EXACT [] synonym: "down-regulation of interleukin-1 production" EXACT [] synonym: "downregulation of interleukin-1 production" EXACT [] synonym: "inhibition of interleukin-1 production" NARROW [] synonym: "negative regulation of IL-1 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production relationship: negatively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032693 name: negative regulation of interleukin-10 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "down regulation of interleukin-10 production" EXACT [] synonym: "down-regulation of interleukin-10 production" EXACT [] synonym: "downregulation of interleukin-10 production" EXACT [] synonym: "inhibition of interleukin-10 production" NARROW [] synonym: "negative regulation of IL-10 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production relationship: negatively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032694 name: negative regulation of interleukin-11 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "down regulation of interleukin-11 production" EXACT [] synonym: "down-regulation of interleukin-11 production" EXACT [] synonym: "downregulation of interleukin-11 production" EXACT [] synonym: "inhibition of interleukin-11 production" NARROW [] synonym: "negative regulation of IL-11 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production relationship: negatively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032695 name: negative regulation of interleukin-12 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "down regulation of interleukin-12 production" EXACT [] synonym: "down-regulation of interleukin-12 production" EXACT [] synonym: "downregulation of interleukin-12 production" EXACT [] synonym: "inhibition of interleukin-12 production" NARROW [] synonym: "negative regulation of IL-12 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production relationship: negatively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032696 name: negative regulation of interleukin-13 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "down regulation of interleukin-13 production" EXACT [] synonym: "down-regulation of interleukin-13 production" EXACT [] synonym: "downregulation of interleukin-13 production" EXACT [] synonym: "inhibition of interleukin-13 production" NARROW [] synonym: "negative regulation of IL-13 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production relationship: negatively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032697 name: negative regulation of interleukin-14 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "down regulation of interleukin-14 production" EXACT [] synonym: "down-regulation of interleukin-14 production" EXACT [] synonym: "downregulation of interleukin-14 production" EXACT [] synonym: "inhibition of interleukin-14 production" NARROW [] synonym: "negative regulation of IL-14 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production relationship: negatively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032698 name: negative regulation of interleukin-15 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "down regulation of interleukin-15 production" EXACT [] synonym: "down-regulation of interleukin-15 production" EXACT [] synonym: "downregulation of interleukin-15 production" EXACT [] synonym: "inhibition of interleukin-15 production" NARROW [] synonym: "negative regulation of IL-15 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production relationship: negatively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032699 name: negative regulation of interleukin-16 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "down regulation of interleukin-16 production" EXACT [] synonym: "down-regulation of interleukin-16 production" EXACT [] synonym: "downregulation of interleukin-16 production" EXACT [] synonym: "inhibition of interleukin-16 production" NARROW [] synonym: "negative regulation of IL-16 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production relationship: negatively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032700 name: negative regulation of interleukin-17 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "down regulation of interleukin-17 production" EXACT [] synonym: "down-regulation of interleukin-17 production" EXACT [] synonym: "downregulation of interleukin-17 production" EXACT [] synonym: "inhibition of interleukin-17 production" NARROW [] synonym: "negative regulation of IL-17 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production relationship: negatively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032701 name: negative regulation of interleukin-18 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "down regulation of interleukin-18 production" EXACT [] synonym: "down-regulation of interleukin-18 production" EXACT [] synonym: "downregulation of interleukin-18 production" EXACT [] synonym: "inhibition of interleukin-18 production" NARROW [] synonym: "negative regulation of IL-18 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production relationship: negatively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032702 name: negative regulation of interleukin-19 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "down regulation of interleukin-19 production" EXACT [] synonym: "down-regulation of interleukin-19 production" EXACT [] synonym: "downregulation of interleukin-19 production" EXACT [] synonym: "inhibition of interleukin-19 production" NARROW [] synonym: "negative regulation of IL-19 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production relationship: negatively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032703 name: negative regulation of interleukin-2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "down regulation of interleukin-2 production" EXACT [] synonym: "down-regulation of interleukin-2 production" EXACT [] synonym: "downregulation of interleukin-2 production" EXACT [] synonym: "inhibition of interleukin-2 production" NARROW [] synonym: "negative regulation of IL-2 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production relationship: negatively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032704 name: negative regulation of interleukin-20 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "down regulation of interleukin-20 production" EXACT [] synonym: "down-regulation of interleukin-20 production" EXACT [] synonym: "downregulation of interleukin-20 production" EXACT [] synonym: "inhibition of interleukin-20 production" NARROW [] synonym: "negative regulation of IL-20 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production relationship: negatively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032705 name: negative regulation of interleukin-21 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "down regulation of interleukin-21 production" EXACT [] synonym: "down-regulation of interleukin-21 production" EXACT [] synonym: "downregulation of interleukin-21 production" EXACT [] synonym: "inhibition of interleukin-21 production" NARROW [] synonym: "negative regulation of IL-21 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production relationship: negatively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032706 name: negative regulation of interleukin-22 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "down regulation of interleukin-22 production" EXACT [] synonym: "down-regulation of interleukin-22 production" EXACT [] synonym: "downregulation of interleukin-22 production" EXACT [] synonym: "inhibition of interleukin-22 production" NARROW [] synonym: "negative regulation of IL-22 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production relationship: negatively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032707 name: negative regulation of interleukin-23 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "down regulation of interleukin-23 production" EXACT [] synonym: "down-regulation of interleukin-23 production" EXACT [] synonym: "downregulation of interleukin-23 production" EXACT [] synonym: "inhibition of interleukin-23 production" NARROW [] synonym: "negative regulation of IL-23 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production relationship: negatively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032708 name: negative regulation of interleukin-24 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "down regulation of interleukin-24 production" EXACT [] synonym: "down-regulation of interleukin-24 production" EXACT [] synonym: "downregulation of interleukin-24 production" EXACT [] synonym: "inhibition of interleukin-24 production" NARROW [] synonym: "negative regulation of IL-24 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production relationship: negatively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032709 name: negative regulation of interleukin-25 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "down regulation of interleukin-25 production" EXACT [] synonym: "down-regulation of interleukin-25 production" EXACT [] synonym: "downregulation of interleukin-25 production" EXACT [] synonym: "inhibition of interleukin-25 production" NARROW [] synonym: "negative regulation of IL-25 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production relationship: negatively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032710 name: negative regulation of interleukin-26 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "down regulation of interleukin-26 production" EXACT [] synonym: "down-regulation of interleukin-26 production" EXACT [] synonym: "downregulation of interleukin-26 production" EXACT [] synonym: "inhibition of interleukin-26 production" NARROW [] synonym: "negative regulation of IL-26 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production relationship: negatively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032711 name: negative regulation of interleukin-27 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "down regulation of interleukin-27 production" EXACT [] synonym: "down-regulation of interleukin-27 production" EXACT [] synonym: "downregulation of interleukin-27 production" EXACT [] synonym: "inhibition of interleukin-27 production" NARROW [] synonym: "negative regulation of IL-27 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production relationship: negatively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032712 name: negative regulation of interleukin-3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "down regulation of interleukin-3 production" EXACT [] synonym: "down-regulation of interleukin-3 production" EXACT [] synonym: "downregulation of interleukin-3 production" EXACT [] synonym: "inhibition of interleukin-3 production" NARROW [] synonym: "negative regulation of IL-3 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production relationship: negatively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032713 name: negative regulation of interleukin-4 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "down regulation of interleukin-4 production" EXACT [] synonym: "down-regulation of interleukin-4 production" EXACT [] synonym: "downregulation of interleukin-4 production" EXACT [] synonym: "inhibition of interleukin-4 production" NARROW [] synonym: "negative regulation of IL-4 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production relationship: negatively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032714 name: negative regulation of interleukin-5 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "down regulation of interleukin-5 production" EXACT [] synonym: "down-regulation of interleukin-5 production" EXACT [] synonym: "downregulation of interleukin-5 production" EXACT [] synonym: "inhibition of interleukin-5 production" NARROW [] synonym: "negative regulation of IL-5 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production relationship: negatively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032715 name: negative regulation of interleukin-6 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "down regulation of interleukin-6 production" EXACT [] synonym: "down-regulation of interleukin-6 production" EXACT [] synonym: "downregulation of interleukin-6 production" EXACT [] synonym: "inhibition of interleukin-6 production" NARROW [] synonym: "negative regulation of IL-6 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production relationship: negatively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032716 name: negative regulation of interleukin-7 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "down regulation of interleukin-7 production" EXACT [] synonym: "down-regulation of interleukin-7 production" EXACT [] synonym: "downregulation of interleukin-7 production" EXACT [] synonym: "inhibition of interleukin-7 production" NARROW [] synonym: "negative regulation of IL-7 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production relationship: negatively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032717 name: negative regulation of interleukin-8 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "down regulation of interleukin-8 production" EXACT [] synonym: "down-regulation of interleukin-8 production" EXACT [] synonym: "downregulation of interleukin-8 production" EXACT [] synonym: "inhibition of interleukin-8 production" NARROW [] synonym: "negative regulation of IL-8 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production relationship: negatively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032718 name: negative regulation of interleukin-9 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "down regulation of interleukin-9 production" EXACT [] synonym: "down-regulation of interleukin-9 production" EXACT [] synonym: "downregulation of interleukin-9 production" EXACT [] synonym: "inhibition of interleukin-9 production" NARROW [] synonym: "negative regulation of IL-9 production" EXACT [] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production relationship: negatively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032719 name: negative regulation of TRAIL production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "down regulation of TRAIL production" EXACT [] synonym: "down-regulation of TRAIL production" EXACT [] synonym: "downregulation of TRAIL production" EXACT [] synonym: "inhibition of TRAIL production" NARROW [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production relationship: negatively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032720 name: negative regulation of tumor necrosis factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "down regulation of tumor necrosis factor production" EXACT [] synonym: "down-regulation of tumor necrosis factor production" EXACT [] synonym: "downregulation of tumor necrosis factor production" EXACT [] synonym: "inhibition of tumor necrosis factor production" NARROW [] synonym: "negative regulation TNF production" EXACT [] synonym: "negative regulation TNF-alpha production" EXACT [] synonym: "negative regulation tumor necrosis factor-alpha production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production relationship: negatively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032721 name: negative regulation of lymphotoxin A production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "down regulation of lymphotoxin A production" EXACT [] synonym: "down-regulation of lymphotoxin A production" EXACT [] synonym: "downregulation of lymphotoxin A production" EXACT [] synonym: "inhibition of lymphotoxin A production" NARROW [] synonym: "negative regulation of LTA production" EXACT [] synonym: "negative regulation of lymphotoxin-alpha production" EXACT [] synonym: "negative regulation of TNF-beta production" EXACT [] synonym: "negative regulation of tumor necrosis factor-beta production" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:1903556 ! negative regulation of tumor necrosis factor superfamily cytokine production relationship: negatively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032722 name: positive regulation of chemokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of chemokine production." [GOC:mah] synonym: "activation of chemokine production" NARROW [] synonym: "stimulation of chemokine production" NARROW [] synonym: "up regulation of chemokine production" EXACT [] synonym: "up-regulation of chemokine production" EXACT [] synonym: "upregulation of chemokine production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032642 ! regulation of chemokine production relationship: positively_regulates GO:0032602 ! chemokine production [Term] id: GO:0032723 name: positive regulation of connective tissue growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production." [GOC:mah] synonym: "activation of connective tissue growth factor production" NARROW [] synonym: "positive regulation of CCN2 production" EXACT [] synonym: "positive regulation of CTGF production" EXACT [] synonym: "positive regulation of Fisp12 production" EXACT [] synonym: "positive regulation of Hcs24 production" EXACT [] synonym: "positive regulation of hypertrophic chondrocyte-specific gene product 24 production" EXACT [] synonym: "positive regulation of IGFBP8 production" EXACT [] synonym: "stimulation of connective tissue growth factor production" NARROW [] synonym: "up regulation of connective tissue growth factor production" EXACT [] synonym: "up-regulation of connective tissue growth factor production" EXACT [] synonym: "upregulation of connective tissue growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032643 ! regulation of connective tissue growth factor production relationship: positively_regulates GO:0032601 ! connective tissue growth factor production [Term] id: GO:0032724 name: positive regulation of fractalkine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of fractalkine production." [GOC:mah] synonym: "activation of fractalkine production" NARROW [] synonym: "stimulation of fractalkine production" NARROW [] synonym: "up regulation of fractalkine production" EXACT [] synonym: "up-regulation of fractalkine production" EXACT [] synonym: "upregulation of fractalkine production" EXACT [] is_a: GO:0032644 ! regulation of fractalkine production is_a: GO:0032722 ! positive regulation of chemokine production relationship: positively_regulates GO:0032603 ! fractalkine production [Term] id: GO:0032725 name: positive regulation of granulocyte macrophage colony-stimulating factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production." [GOC:mah] synonym: "activation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "positive regulation of GM-CSF production" EXACT [GOC:vk] synonym: "positive regulation of granulocyte macrophage colony stimulating factor production" EXACT [] synonym: "stimulation of granulocyte macrophage colony-stimulating factor production" NARROW [] synonym: "up regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "up-regulation of granulocyte macrophage colony-stimulating factor production" EXACT [] synonym: "upregulation of granulocyte macrophage colony-stimulating factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032645 ! regulation of granulocyte macrophage colony-stimulating factor production relationship: positively_regulates GO:0032604 ! granulocyte macrophage colony-stimulating factor production [Term] id: GO:0032726 name: positive regulation of hepatocyte growth factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production." [GOC:mah] synonym: "activation of hepatocyte growth factor production" NARROW [] synonym: "stimulation of hepatocyte growth factor production" NARROW [] synonym: "up regulation of hepatocyte growth factor production" EXACT [] synonym: "up-regulation of hepatocyte growth factor production" EXACT [] synonym: "upregulation of hepatocyte growth factor production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032646 ! regulation of hepatocyte growth factor production relationship: positively_regulates GO:0032605 ! hepatocyte growth factor production [Term] id: GO:0032727 name: positive regulation of interferon-alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-alpha production." [GOC:mah] synonym: "activation of interferon-alpha production" NARROW [] synonym: "stimulation of interferon-alpha production" NARROW [] synonym: "up regulation of interferon-alpha production" EXACT [] synonym: "up-regulation of interferon-alpha production" EXACT [] synonym: "upregulation of interferon-alpha production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032647 ! regulation of interferon-alpha production relationship: positively_regulates GO:0032607 ! interferon-alpha production [Term] id: GO:0032728 name: positive regulation of interferon-beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-beta production." [GOC:mah] synonym: "activation of interferon-beta production" NARROW [] synonym: "positive regulation of IFN-beta production" EXACT [] synonym: "stimulation of interferon-beta production" NARROW [] synonym: "up regulation of interferon-beta production" EXACT [] synonym: "up-regulation of interferon-beta production" EXACT [] synonym: "upregulation of interferon-beta production" EXACT [] is_a: GO:0032481 ! positive regulation of type I interferon production is_a: GO:0032648 ! regulation of interferon-beta production relationship: positively_regulates GO:0032608 ! interferon-beta production [Term] id: GO:0032729 name: positive regulation of interferon-gamma production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:mah] synonym: "activation of interferon-gamma production" NARROW [] synonym: "positive regulation of type II interferon production" BROAD [] synonym: "stimulation of interferon-gamma production" NARROW [] synonym: "up regulation of interferon-gamma production" EXACT [] synonym: "up-regulation of interferon-gamma production" EXACT [] synonym: "upregulation of interferon-gamma production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032649 ! regulation of interferon-gamma production relationship: positively_regulates GO:0032609 ! interferon-gamma production [Term] id: GO:0032730 name: positive regulation of interleukin-1 alpha production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production." [GOC:mah] synonym: "activation of interleukin-1 alpha production" NARROW [] synonym: "positive regulation of IL-1 alpha production" EXACT [] synonym: "stimulation of interleukin-1 alpha production" NARROW [] synonym: "up regulation of interleukin-1 alpha production" EXACT [] synonym: "up-regulation of interleukin-1 alpha production" EXACT [] synonym: "upregulation of interleukin-1 alpha production" EXACT [] is_a: GO:0032650 ! regulation of interleukin-1 alpha production is_a: GO:0032732 ! positive regulation of interleukin-1 production relationship: positively_regulates GO:0032610 ! interleukin-1 alpha production [Term] id: GO:0032731 name: positive regulation of interleukin-1 beta production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production." [GOC:mah] synonym: "activation of interleukin-1 beta production" NARROW [] synonym: "positive regulation of IL-1 beta production" EXACT [] synonym: "stimulation of interleukin-1 beta production" NARROW [] synonym: "up regulation of interleukin-1 beta production" EXACT [] synonym: "up-regulation of interleukin-1 beta production" EXACT [] synonym: "upregulation of interleukin-1 beta production" EXACT [] is_a: GO:0032651 ! regulation of interleukin-1 beta production is_a: GO:0032732 ! positive regulation of interleukin-1 production relationship: positively_regulates GO:0032611 ! interleukin-1 beta production [Term] id: GO:0032732 name: positive regulation of interleukin-1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-1 production." [GOC:mah] synonym: "activation of interleukin-1 production" NARROW [] synonym: "positive regulation of IL-1 production" EXACT [] synonym: "stimulation of interleukin-1 production" NARROW [] synonym: "up regulation of interleukin-1 production" EXACT [] synonym: "up-regulation of interleukin-1 production" EXACT [] synonym: "upregulation of interleukin-1 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032652 ! regulation of interleukin-1 production relationship: positively_regulates GO:0032612 ! interleukin-1 production [Term] id: GO:0032733 name: positive regulation of interleukin-10 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-10 production." [GOC:mah] synonym: "activation of interleukin-10 production" NARROW [] synonym: "positive regulation of IL-10 production" EXACT [] synonym: "stimulation of interleukin-10 production" NARROW [] synonym: "up regulation of interleukin-10 production" EXACT [] synonym: "up-regulation of interleukin-10 production" EXACT [] synonym: "upregulation of interleukin-10 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032653 ! regulation of interleukin-10 production relationship: positively_regulates GO:0032613 ! interleukin-10 production [Term] id: GO:0032734 name: positive regulation of interleukin-11 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-11 production." [GOC:mah] synonym: "activation of interleukin-11 production" NARROW [] synonym: "positive regulation of IL-11 production" EXACT [] synonym: "stimulation of interleukin-11 production" NARROW [] synonym: "up regulation of interleukin-11 production" EXACT [] synonym: "up-regulation of interleukin-11 production" EXACT [] synonym: "upregulation of interleukin-11 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032654 ! regulation of interleukin-11 production relationship: positively_regulates GO:0032614 ! interleukin-11 production [Term] id: GO:0032735 name: positive regulation of interleukin-12 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-12 production." [GOC:mah] synonym: "activation of interleukin-12 production" NARROW [] synonym: "positive regulation of IL-12 production" EXACT [] synonym: "stimulation of interleukin-12 production" NARROW [] synonym: "up regulation of interleukin-12 production" EXACT [] synonym: "up-regulation of interleukin-12 production" EXACT [] synonym: "upregulation of interleukin-12 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032655 ! regulation of interleukin-12 production relationship: positively_regulates GO:0032615 ! interleukin-12 production [Term] id: GO:0032736 name: positive regulation of interleukin-13 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-13 production." [GOC:mah] synonym: "activation of interleukin-13 production" NARROW [] synonym: "positive regulation of IL-13 production" EXACT [] synonym: "stimulation of interleukin-13 production" NARROW [] synonym: "up regulation of interleukin-13 production" EXACT [] synonym: "up-regulation of interleukin-13 production" EXACT [] synonym: "upregulation of interleukin-13 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032656 ! regulation of interleukin-13 production relationship: positively_regulates GO:0032616 ! interleukin-13 production [Term] id: GO:0032737 name: positive regulation of interleukin-14 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-14 production." [GOC:mah] synonym: "activation of interleukin-14 production" NARROW [] synonym: "positive regulation of IL-14 production" EXACT [] synonym: "stimulation of interleukin-14 production" NARROW [] synonym: "up regulation of interleukin-14 production" EXACT [] synonym: "up-regulation of interleukin-14 production" EXACT [] synonym: "upregulation of interleukin-14 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032657 ! regulation of interleukin-14 production relationship: positively_regulates GO:0032617 ! interleukin-14 production [Term] id: GO:0032738 name: positive regulation of interleukin-15 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-15 production." [GOC:mah] synonym: "activation of interleukin-15 production" NARROW [] synonym: "positive regulation of IL-15 production" EXACT [] synonym: "stimulation of interleukin-15 production" NARROW [] synonym: "up regulation of interleukin-15 production" EXACT [] synonym: "up-regulation of interleukin-15 production" EXACT [] synonym: "upregulation of interleukin-15 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032658 ! regulation of interleukin-15 production relationship: positively_regulates GO:0032618 ! interleukin-15 production [Term] id: GO:0032739 name: positive regulation of interleukin-16 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-16 production." [GOC:mah] synonym: "activation of interleukin-16 production" NARROW [] synonym: "positive regulation of IL-16 production" EXACT [] synonym: "stimulation of interleukin-16 production" NARROW [] synonym: "up regulation of interleukin-16 production" EXACT [] synonym: "up-regulation of interleukin-16 production" EXACT [] synonym: "upregulation of interleukin-16 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032659 ! regulation of interleukin-16 production relationship: positively_regulates GO:0032619 ! interleukin-16 production [Term] id: GO:0032740 name: positive regulation of interleukin-17 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines." [GOC:add, GOC:mah] synonym: "activation of interleukin-17 production" NARROW [] synonym: "positive regulation of IL-17 production" EXACT [] synonym: "stimulation of interleukin-17 production" NARROW [] synonym: "up regulation of interleukin-17 production" EXACT [] synonym: "up-regulation of interleukin-17 production" EXACT [] synonym: "upregulation of interleukin-17 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032660 ! regulation of interleukin-17 production relationship: positively_regulates GO:0032620 ! interleukin-17 production [Term] id: GO:0032741 name: positive regulation of interleukin-18 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-18 production." [GOC:mah] synonym: "activation of interleukin-18 production" NARROW [] synonym: "positive regulation of IL-18 production" EXACT [] synonym: "stimulation of interleukin-18 production" NARROW [] synonym: "up regulation of interleukin-18 production" EXACT [] synonym: "up-regulation of interleukin-18 production" EXACT [] synonym: "upregulation of interleukin-18 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032661 ! regulation of interleukin-18 production relationship: positively_regulates GO:0032621 ! interleukin-18 production [Term] id: GO:0032742 name: positive regulation of interleukin-19 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-19 production." [GOC:mah] synonym: "activation of interleukin-19 production" NARROW [] synonym: "positive regulation of IL-19 production" EXACT [] synonym: "stimulation of interleukin-19 production" NARROW [] synonym: "up regulation of interleukin-19 production" EXACT [] synonym: "up-regulation of interleukin-19 production" EXACT [] synonym: "upregulation of interleukin-19 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032662 ! regulation of interleukin-19 production relationship: positively_regulates GO:0032622 ! interleukin-19 production [Term] id: GO:0032743 name: positive regulation of interleukin-2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-2 production." [GOC:mah] synonym: "activation of interleukin-2 production" NARROW [] synonym: "positive regulation of IL-2 production" EXACT [] synonym: "stimulation of interleukin-2 production" NARROW [] synonym: "up regulation of interleukin-2 production" EXACT [] synonym: "up-regulation of interleukin-2 production" EXACT [] synonym: "upregulation of interleukin-2 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032663 ! regulation of interleukin-2 production relationship: positively_regulates GO:0032623 ! interleukin-2 production [Term] id: GO:0032744 name: positive regulation of interleukin-20 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-20 production." [GOC:mah] synonym: "activation of interleukin-20 production" NARROW [] synonym: "positive regulation of IL-20 production" EXACT [] synonym: "stimulation of interleukin-20 production" NARROW [] synonym: "up regulation of interleukin-20 production" EXACT [] synonym: "up-regulation of interleukin-20 production" EXACT [] synonym: "upregulation of interleukin-20 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032664 ! regulation of interleukin-20 production relationship: positively_regulates GO:0032624 ! interleukin-20 production [Term] id: GO:0032745 name: positive regulation of interleukin-21 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-21 production." [GOC:mah] synonym: "activation of interleukin-21 production" NARROW [] synonym: "positive regulation of IL-21 production" EXACT [] synonym: "stimulation of interleukin-21 production" NARROW [] synonym: "up regulation of interleukin-21 production" EXACT [] synonym: "up-regulation of interleukin-21 production" EXACT [] synonym: "upregulation of interleukin-21 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032665 ! regulation of interleukin-21 production relationship: positively_regulates GO:0032625 ! interleukin-21 production [Term] id: GO:0032746 name: positive regulation of interleukin-22 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-22 production." [GOC:mah] synonym: "activation of interleukin-22 production" NARROW [] synonym: "positive regulation of IL-22 production" EXACT [] synonym: "stimulation of interleukin-22 production" NARROW [] synonym: "up regulation of interleukin-22 production" EXACT [] synonym: "up-regulation of interleukin-22 production" EXACT [] synonym: "upregulation of interleukin-22 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032666 ! regulation of interleukin-22 production relationship: positively_regulates GO:0032626 ! interleukin-22 production [Term] id: GO:0032747 name: positive regulation of interleukin-23 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-23 production." [GOC:mah] synonym: "activation of interleukin-23 production" NARROW [] synonym: "positive regulation of IL-23 production" EXACT [] synonym: "stimulation of interleukin-23 production" NARROW [] synonym: "up regulation of interleukin-23 production" EXACT [] synonym: "up-regulation of interleukin-23 production" EXACT [] synonym: "upregulation of interleukin-23 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032667 ! regulation of interleukin-23 production relationship: positively_regulates GO:0032627 ! interleukin-23 production [Term] id: GO:0032748 name: positive regulation of interleukin-24 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-24 production." [GOC:mah] synonym: "activation of interleukin-24 production" NARROW [] synonym: "positive regulation of IL-24 production" EXACT [] synonym: "stimulation of interleukin-24 production" NARROW [] synonym: "up regulation of interleukin-24 production" EXACT [] synonym: "up-regulation of interleukin-24 production" EXACT [] synonym: "upregulation of interleukin-24 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032668 ! regulation of interleukin-24 production relationship: positively_regulates GO:0032628 ! interleukin-24 production [Term] id: GO:0032749 name: positive regulation of interleukin-25 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-25 production." [GOC:mah] synonym: "activation of interleukin-25 production" NARROW [] synonym: "positive regulation of IL-25 production" EXACT [] synonym: "stimulation of interleukin-25 production" NARROW [] synonym: "up regulation of interleukin-25 production" EXACT [] synonym: "up-regulation of interleukin-25 production" EXACT [] synonym: "upregulation of interleukin-25 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032669 ! regulation of interleukin-25 production relationship: positively_regulates GO:0032629 ! interleukin-25 production [Term] id: GO:0032750 name: positive regulation of interleukin-26 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-26 production." [GOC:mah] synonym: "activation of interleukin-26 production" NARROW [] synonym: "positive regulation of IL-26 production" EXACT [] synonym: "stimulation of interleukin-26 production" NARROW [] synonym: "up regulation of interleukin-26 production" EXACT [] synonym: "up-regulation of interleukin-26 production" EXACT [] synonym: "upregulation of interleukin-26 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032670 ! regulation of interleukin-26 production relationship: positively_regulates GO:0032630 ! interleukin-26 production [Term] id: GO:0032751 name: positive regulation of interleukin-27 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-27 production." [GOC:mah] synonym: "activation of interleukin-27 production" NARROW [] synonym: "positive regulation of IL-27 production" EXACT [] synonym: "stimulation of interleukin-27 production" NARROW [] synonym: "up regulation of interleukin-27 production" EXACT [] synonym: "up-regulation of interleukin-27 production" EXACT [] synonym: "upregulation of interleukin-27 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032671 ! regulation of interleukin-27 production relationship: positively_regulates GO:0032631 ! interleukin-27 production [Term] id: GO:0032752 name: positive regulation of interleukin-3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-3 production." [GOC:mah] synonym: "activation of interleukin-3 production" NARROW [] synonym: "positive regulation of IL-3 production" EXACT [] synonym: "stimulation of interleukin-3 production" NARROW [] synonym: "up regulation of interleukin-3 production" EXACT [] synonym: "up-regulation of interleukin-3 production" EXACT [] synonym: "upregulation of interleukin-3 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032672 ! regulation of interleukin-3 production relationship: positively_regulates GO:0032632 ! interleukin-3 production [Term] id: GO:0032753 name: positive regulation of interleukin-4 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-4 production." [GOC:mah] synonym: "activation of interleukin-4 production" NARROW [] synonym: "positive regulation of IL-4 production" EXACT [] synonym: "stimulation of interleukin-4 production" NARROW [] synonym: "up regulation of interleukin-4 production" EXACT [] synonym: "up-regulation of interleukin-4 production" EXACT [] synonym: "upregulation of interleukin-4 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032673 ! regulation of interleukin-4 production relationship: positively_regulates GO:0032633 ! interleukin-4 production [Term] id: GO:0032754 name: positive regulation of interleukin-5 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-5 production." [GOC:mah] synonym: "activation of interleukin-5 production" NARROW [] synonym: "positive regulation of IL-5 production" EXACT [] synonym: "stimulation of interleukin-5 production" NARROW [] synonym: "up regulation of interleukin-5 production" EXACT [] synonym: "up-regulation of interleukin-5 production" EXACT [] synonym: "upregulation of interleukin-5 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032674 ! regulation of interleukin-5 production relationship: positively_regulates GO:0032634 ! interleukin-5 production [Term] id: GO:0032755 name: positive regulation of interleukin-6 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-6 production." [GOC:mah] synonym: "activation of interleukin-6 production" NARROW [] synonym: "positive regulation of IL-6 production" EXACT [] synonym: "stimulation of interleukin-6 production" NARROW [] synonym: "up regulation of interleukin-6 production" EXACT [] synonym: "up-regulation of interleukin-6 production" EXACT [] synonym: "upregulation of interleukin-6 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032675 ! regulation of interleukin-6 production relationship: positively_regulates GO:0032635 ! interleukin-6 production [Term] id: GO:0032756 name: positive regulation of interleukin-7 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-7 production." [GOC:mah] synonym: "activation of interleukin-7 production" NARROW [] synonym: "positive regulation of IL-7 production" EXACT [] synonym: "stimulation of interleukin-7 production" NARROW [] synonym: "up regulation of interleukin-7 production" EXACT [] synonym: "up-regulation of interleukin-7 production" EXACT [] synonym: "upregulation of interleukin-7 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032676 ! regulation of interleukin-7 production relationship: positively_regulates GO:0032636 ! interleukin-7 production [Term] id: GO:0032757 name: positive regulation of interleukin-8 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-8 production." [GOC:mah] synonym: "activation of interleukin-8 production" NARROW [] synonym: "positive regulation of IL-8 production" EXACT [] synonym: "stimulation of interleukin-8 production" NARROW [] synonym: "up regulation of interleukin-8 production" EXACT [] synonym: "up-regulation of interleukin-8 production" EXACT [] synonym: "upregulation of interleukin-8 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032677 ! regulation of interleukin-8 production relationship: positively_regulates GO:0032637 ! interleukin-8 production [Term] id: GO:0032758 name: positive regulation of interleukin-9 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of interleukin-9 production." [GOC:mah] synonym: "activation of interleukin-9 production" NARROW [] synonym: "positive regulation of IL-9 production" EXACT [] synonym: "stimulation of interleukin-9 production" NARROW [] synonym: "up regulation of interleukin-9 production" EXACT [] synonym: "up-regulation of interleukin-9 production" EXACT [] synonym: "upregulation of interleukin-9 production" EXACT [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0032678 ! regulation of interleukin-9 production relationship: positively_regulates GO:0032638 ! interleukin-9 production [Term] id: GO:0032759 name: positive regulation of TRAIL production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of TRAIL production." [GOC:mah] synonym: "activation of TRAIL production" NARROW [] synonym: "stimulation of TRAIL production" NARROW [] synonym: "up regulation of TRAIL production" EXACT [] synonym: "up-regulation of TRAIL production" EXACT [] synonym: "upregulation of TRAIL production" EXACT [] is_a: GO:0032679 ! regulation of TRAIL production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production relationship: positively_regulates GO:0032639 ! TRAIL production [Term] id: GO:0032760 name: positive regulation of tumor necrosis factor production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tumor necrosis factor production." [GOC:mah] comment: Note that this term refers only to the specific, original 'tumor necrosis factor' protein (TNF) and not other members of the tumor necrosis factor superfamily (those with the gene symbol root 'TNFSF'). synonym: "activation of tumor necrosis factor production" NARROW [] synonym: "positive regulation of TNF production" EXACT [] synonym: "positive regulation of TNF-alpha production" EXACT [] synonym: "positive regulation of tumor necrosis factor-alpha production" EXACT [] synonym: "stimulation of tumor necrosis factor production" NARROW [] synonym: "up regulation of tumor necrosis factor production" EXACT [] synonym: "up-regulation of tumor necrosis factor production" EXACT [] synonym: "upregulation of tumor necrosis factor production" EXACT [] is_a: GO:0032680 ! regulation of tumor necrosis factor production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production relationship: positively_regulates GO:0032640 ! tumor necrosis factor production [Term] id: GO:0032761 name: positive regulation of lymphotoxin A production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphotoxin A production." [GOC:mah] synonym: "activation of lymphotoxin A production" NARROW [] synonym: "positive regulation of LTA production" EXACT [] synonym: "positive regulation of lymphotoxin-alpha production" EXACT [] synonym: "positive regulation of TNF-beta production" EXACT [] synonym: "positive regulation of tumor necrosis factor-beta production" EXACT [] synonym: "stimulation of lymphotoxin A production" NARROW [] synonym: "up regulation of lymphotoxin A production" EXACT [] synonym: "up-regulation of lymphotoxin A production" EXACT [] synonym: "upregulation of lymphotoxin A production" EXACT [] is_a: GO:0032681 ! regulation of lymphotoxin A production is_a: GO:1903557 ! positive regulation of tumor necrosis factor superfamily cytokine production relationship: positively_regulates GO:0032641 ! lymphotoxin A production [Term] id: GO:0032762 name: mast cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a mast cell." [GOC:mah] is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0032763 name: regulation of mast cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] is_a: GO:0002718 ! regulation of cytokine production involved in immune response relationship: regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032764 name: negative regulation of mast cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "down regulation of mast cell cytokine production" EXACT [] synonym: "down-regulation of mast cell cytokine production" EXACT [] synonym: "downregulation of mast cell cytokine production" EXACT [] synonym: "inhibition of mast cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0032763 ! regulation of mast cell cytokine production relationship: negatively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032765 name: positive regulation of mast cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production." [GOC:mah] synonym: "activation of mast cell cytokine production" NARROW [] synonym: "stimulation of mast cell cytokine production" NARROW [] synonym: "up regulation of mast cell cytokine production" EXACT [] synonym: "up-regulation of mast cell cytokine production" EXACT [] synonym: "upregulation of mast cell cytokine production" EXACT [] is_a: GO:0032763 ! regulation of mast cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response relationship: positively_regulates GO:0032762 ! mast cell cytokine production [Term] id: GO:0032766 name: NHE3/E3KARP/ACTN4 complex namespace: cellular_component def: "A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments." [PMID:11948184] synonym: "NHE3/E3KARP/alpha-actinin complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0032767 name: copper-dependent protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules), in the presence of copper." [GOC:ecd, PMID:16884690] is_a: GO:0005515 ! protein binding [Term] id: GO:0032768 name: regulation of monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of a monooxygenase." [GOC:mah] is_a: GO:0051341 ! regulation of oxidoreductase activity [Term] id: GO:0032769 name: negative regulation of monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of a monooxygenase." [GOC:mah] synonym: "down regulation of monooxygenase activity" EXACT [] synonym: "down-regulation of monooxygenase activity" EXACT [] synonym: "downregulation of monooxygenase activity" EXACT [] synonym: "inhibition of monooxygenase activity" NARROW [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051354 ! negative regulation of oxidoreductase activity [Term] id: GO:0032770 name: positive regulation of monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of a monooxygenase." [GOC:mah] synonym: "activation of monooxygenase activity" NARROW [] synonym: "stimulation of monooxygenase activity" NARROW [] synonym: "up regulation of monooxygenase activity" EXACT [] synonym: "up-regulation of monooxygenase activity" EXACT [] synonym: "upregulation of monooxygenase activity" EXACT [] is_a: GO:0032768 ! regulation of monooxygenase activity is_a: GO:0051353 ! positive regulation of oxidoreductase activity [Term] id: GO:0032771 name: regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that modulates the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0032768 ! regulation of monooxygenase activity [Term] id: GO:0032772 name: negative regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that stops or reduces the activity of the enzyme monophenol monooxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb] synonym: "down regulation of monophenol oxygenase activity" EXACT [] synonym: "down-regulation of monophenol oxygenase activity" EXACT [] synonym: "downregulation of monophenol oxygenase activity" EXACT [] synonym: "inhibition of monophenol oxygenase activity" NARROW [] synonym: "negative regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] is_a: GO:0032769 ! negative regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity [Term] id: GO:0032773 name: positive regulation of monophenol monooxygenase activity namespace: biological_process def: "Any process that activates or increases the activity of the enzyme monophenol oxygenase. Monophenol monooxygenase catalyzes the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [GOC:dph, GOC:mah, GOC:tb, PMID:2494997] synonym: "activation of monophenol oxygenase activity" NARROW [] synonym: "positive regulation of monophenol oxygenase activity" EXACT [GOC:dph, GOC:tb, PMID:2494997] synonym: "stimulation of monophenol oxygenase activity" NARROW [] synonym: "up regulation of monophenol oxygenase activity" EXACT [] synonym: "up-regulation of monophenol oxygenase activity" EXACT [] synonym: "upregulation of monophenol oxygenase activity" EXACT [] is_a: GO:0032770 ! positive regulation of monooxygenase activity is_a: GO:0032771 ! regulation of monophenol monooxygenase activity [Term] id: GO:0032774 name: RNA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication." [GOC:mah, GOC:txnOH] comment: Note that, in some cases, viral RNA replication and viral transcription from RNA actually refer to the same process, but may be called differently depending on the focus of a specific research study. synonym: "RNA anabolism" EXACT [] synonym: "RNA biosynthesis" EXACT [] synonym: "RNA formation" EXACT [] synonym: "RNA synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016070 ! RNA metabolic process is_a: GO:0034654 ! nucleobase-containing compound biosynthetic process [Term] id: GO:0032775 name: DNA methylation on adenine namespace: biological_process def: "The covalent transfer of a methyl group to N-6 of adenine in a DNA molecule." [GOC:pf] synonym: "adenine methylation" RELATED [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032776 name: DNA methylation on cytosine namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of cytosine in a DNA molecule." [GOC:pf] synonym: "cytosine methylation" BROAD [] is_a: GO:0006306 ! DNA methylation [Term] id: GO:0032777 name: Piccolo NuA4 histone acetyltransferase complex namespace: cellular_component def: "A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p." [GOC:rb, PMID:12782659, PMID:15964809] is_a: GO:0035267 ! NuA4 histone acetyltransferase complex [Term] id: GO:0032778 name: cobalt-transporting ATPase activity namespace: molecular_function alt_id: GO:0015632 def: "Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in)." [GOC:mlg, GOC:mtg_transport, ISBN:0815340729] synonym: "cobalt ABC transporter" RELATED [] synonym: "cobalt porter activity" RELATED [] synonym: "cobalt transporting ATPase activity" EXACT [] xref: RHEA:32779 is_a: GO:0015087 ! cobalt ion transmembrane transporter activity is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0032780 name: negative regulation of ATPase activity namespace: biological_process def: "Any process that stops or reduces the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "down regulation of ATPase activity" EXACT [] synonym: "down-regulation of ATPase activity" EXACT [] synonym: "downregulation of ATPase activity" EXACT [] synonym: "inhibition of ATPase activity" NARROW [] synonym: "negative regulation of adenosinetriphosphatase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051346 ! negative regulation of hydrolase activity [Term] id: GO:0032781 name: positive regulation of ATPase activity namespace: biological_process def: "Any process that activates or increases the rate of ATP hydrolysis by an ATPase." [GOC:mah] synonym: "activation of ATPase activity" NARROW [] synonym: "positive regulation of adenosinetriphosphatase activity" EXACT [] synonym: "stimulation of ATPase activity" NARROW [] synonym: "up regulation of ATPase activity" EXACT [] synonym: "up-regulation of ATPase activity" EXACT [] synonym: "upregulation of ATPase activity" EXACT [] is_a: GO:0043462 ! regulation of ATPase activity is_a: GO:0051345 ! positive regulation of hydrolase activity [Term] id: GO:0032782 name: bile acid secretion namespace: biological_process def: "The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue." [GOC:ecd] is_a: GO:0015718 ! monocarboxylic acid transport is_a: GO:0046717 ! acid secretion [Term] id: GO:0032783 name: ELL-EAF complex namespace: cellular_component def: "A heterodimeric protein complex that acts as an RNA polymerase II elongation factor; the complex is conserved from yeast to humans, and is present in S. pombe, but absent from S. cerevisiae." [PMID:17150956] is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0032784 name: regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "regulation of RNA elongation" BROAD [] synonym: "regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "regulation of transcriptional elongation" BROAD [] synonym: "transcription elongation regulator activity" RELATED [] is_a: GO:0006355 ! regulation of transcription, DNA-templated relationship: regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032785 name: negative regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "down regulation of RNA elongation" BROAD [] synonym: "down-regulation of RNA elongation" BROAD [] synonym: "downregulation of RNA elongation" BROAD [] synonym: "inhibition of RNA elongation" BROAD [] synonym: "negative regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "negative regulation of transcription elongation" BROAD [] synonym: "negative regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "negative regulation of transcriptional elongation" BROAD [] synonym: "negative transcription elongation regulator activity" RELATED [] is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation is_a: GO:0045892 ! negative regulation of transcription, DNA-templated relationship: negatively_regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032786 name: positive regulation of DNA-templated transcription, elongation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase." [GOC:mah, GOC:txnOH] synonym: "activation of RNA elongation" BROAD [] synonym: "positive regulation of DNA-dependent transcription, elongation" EXACT [GOC:txnOH] synonym: "positive regulation of transcription elongation" BROAD [] synonym: "positive regulation of transcription elongation, DNA-dependent" EXACT [GOC:jh2] synonym: "positive regulation of transcriptional elongation" BROAD [] synonym: "positive transcription elongation regulator activity" RELATED [] synonym: "stimulation of RNA elongation" BROAD [] synonym: "up regulation of RNA elongation" BROAD [] synonym: "up-regulation of RNA elongation" BROAD [] synonym: "upregulation of RNA elongation" BROAD [] is_a: GO:0032784 ! regulation of DNA-templated transcription, elongation is_a: GO:0045893 ! positive regulation of transcription, DNA-templated relationship: positively_regulates GO:0006354 ! DNA-templated transcription, elongation [Term] id: GO:0032787 name: monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-)." [GOC:vk] subset: goslim_yeast synonym: "monocarboxylate metabolic process" EXACT [] synonym: "monocarboxylic acid metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0032788 name: saturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds." [GOC:mah, GOC:vk] synonym: "saturated monocarboxylate metabolic process" EXACT [] synonym: "saturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032789 name: unsaturated monocarboxylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds." [GOC:mah, GOC:vk] synonym: "unsaturated monocarboxylate metabolic process" EXACT [] synonym: "unsaturated monocarboxylic acid metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0032790 name: ribosome disassembly namespace: biological_process def: "The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits." [GOC:mah, GOC:vk] synonym: "ribosome dissociation factor" RELATED [] synonym: "ribosome recycling" NARROW [GOC:db, PMID:9463391] is_a: GO:0032988 ! ribonucleoprotein complex disassembly is_a: GO:1903008 ! organelle disassembly [Term] id: GO:0032791 name: lead ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with lead (Pb) ions." [GOC:mah] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0032792 name: negative regulation of CREB transcription factor activity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "CREB inhibitor" RELATED [] synonym: "inhibition of CREB transcription factor" EXACT [GOC:dph, GOC:tb] is_a: GO:0043433 ! negative regulation of DNA-binding transcription factor activity [Term] id: GO:0032793 name: positive regulation of CREB transcription factor activity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB." [GOC:dph, GOC:ecd, GOC:tb] synonym: "activation of CREB" EXACT [] synonym: "activation of CREB transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "CREB activator" RELATED [] is_a: GO:0051091 ! positive regulation of DNA-binding transcription factor activity [Term] id: GO:0032794 name: GTPase activating protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a GTPase activating protein." [GOC:nln] synonym: "GAP binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0032795 name: heterotrimeric G-protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a heterotrimeric G-protein." [GOC:nln] is_a: GO:0044877 ! protein-containing complex binding [Term] id: GO:0032796 name: uropod organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated." [GOC:add, ISBN:0781735149, PMID:12714569, PMID:12787750] synonym: "uropod organisation" EXACT [GOC:mah] synonym: "uropod organization and biogenesis" RELATED [GOC:mah] is_a: GO:0120036 ! plasma membrane bounded cell projection organization [Term] id: GO:0032797 name: SMN complex namespace: cellular_component def: "A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus." [PMID:16434402, PMID:17023415] comment: Note that a larger complex containing Sm proteins and other subunits is also sometimes referred to as the 'SMN complex'. The larger complex is represented by 'SMN-Sm protein complex ; GO:0034719'. synonym: "SMN core complex" EXACT [] synonym: "survival motor neuron complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032798 name: Swi5-Sfr1 complex namespace: cellular_component def: "A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces)." [PMID:15620352, PMID:16921379] comment: Note that this term refers to Schizosaccharomyces pombe Swi5, which should not be confused with the unrelated Saccharomyces Swi5p. synonym: "Sae3-Mei5 complex" EXACT [GOC:elh, GOC:vw] synonym: "Swi5 complex" BROAD [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0032799 name: low-density lipoprotein receptor particle metabolic process namespace: biological_process def: "The chemical reactions and pathways involving low-density lipoprotein receptors." [GOC:vk] synonym: "LDL receptor metabolic process" EXACT [] synonym: "low-density lipoprotein receptor metabolic process" EXACT [GOC:bf, GOC:dph] synonym: "low-density lipoprotein receptor metabolism" EXACT [] is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032800 name: receptor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor anabolism" EXACT [] synonym: "receptor biosynthesis" EXACT [] synonym: "receptor formation" EXACT [] synonym: "receptor synthesis" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0032801 name: receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "receptor breakdown" EXACT [] synonym: "receptor catabolism" EXACT [] synonym: "receptor degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0043112 ! receptor metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0032802 name: low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:mah] synonym: "LDL receptor breakdown" EXACT [] synonym: "LDL receptor catabolic process" EXACT [] synonym: "LDL receptor catabolism" RELATED [] synonym: "LDL receptor degradation" EXACT [] synonym: "low-density lipoprotein receptor breakdown" EXACT [] synonym: "low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "low-density lipoprotein receptor catabolism" EXACT [] synonym: "low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032799 ! low-density lipoprotein receptor particle metabolic process is_a: GO:0032801 ! receptor catabolic process is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0032803 name: regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "regulation of LDLr catabolic process" EXACT [] synonym: "regulation of LDLr catabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] synonym: "regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:1903362 ! regulation of cellular protein catabolic process is_a: GO:2000644 ! regulation of receptor catabolic process relationship: regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032804 name: negative regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors." [GOC:mah] synonym: "down regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "down-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "downregulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "inhibition of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "negative regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:dph] synonym: "negative regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "negative regulation of low-density lipoprotein receptor degradation" EXACT [] is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:1903363 ! negative regulation of cellular protein catabolic process is_a: GO:2000645 ! negative regulation of receptor catabolic process relationship: negatively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032805 name: positive regulation of low-density lipoprotein particle receptor catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors." [GOC:mah] synonym: "activation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "positive regulation of low-density lipoprotein receptor breakdown" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor catabolic process" EXACT [GOC:bf, GOC:dph] synonym: "positive regulation of low-density lipoprotein receptor catabolism" EXACT [] synonym: "positive regulation of low-density lipoprotein receptor degradation" EXACT [] synonym: "stimulation of low-density lipoprotein receptor catabolic process" NARROW [] synonym: "up regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "up-regulation of low-density lipoprotein receptor catabolic process" EXACT [] synonym: "upregulation of low-density lipoprotein receptor catabolic process" EXACT [] is_a: GO:0032803 ! regulation of low-density lipoprotein particle receptor catabolic process is_a: GO:1903364 ! positive regulation of cellular protein catabolic process is_a: GO:2000646 ! positive regulation of receptor catabolic process relationship: positively_regulates GO:0032802 ! low-density lipoprotein particle receptor catabolic process [Term] id: GO:0032806 name: carboxy-terminal domain protein kinase complex namespace: cellular_component def: "A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5." [PMID:15047695, PMID:16721054, PMID:17079683] synonym: "CTDK complex" EXACT [] is_a: GO:0044428 ! nuclear part is_a: GO:1902554 ! serine/threonine protein kinase complex [Term] id: GO:0032807 name: DNA ligase IV complex namespace: cellular_component def: "A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p." [PMID:16314503] synonym: "DNA ligase IV-XRCC4 complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0032808 name: lacrimal gland development namespace: biological_process def: "The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye." [GOC:ln] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0032809 name: neuronal cell body membrane namespace: cellular_component def: "The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites." [GOC:jl] synonym: "neuron cell body membrane" EXACT [] synonym: "neuronal cell soma membrane" EXACT [] is_a: GO:0044298 ! cell body membrane is_a: GO:0097458 ! neuron part relationship: part_of GO:0043025 ! neuronal cell body [Term] id: GO:0032810 name: sterol response element binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism." [GOC:vk, PMID:11994399] comment: Note that as agreed during the transcription overhaul, terms specifying binding to specific transcription regulatory motifs are no longer being created. The level of specificity GO has decided to go to is the "core promoter", "core promoter proximal region" and "enhancer". To capture more detail, please consider using column 16. synonym: "SRE binding" EXACT [] is_a: GO:0000978 ! RNA polymerase II proximal promoter sequence-specific DNA binding [Term] id: GO:0032811 name: negative regulation of epinephrine secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "down regulation of epinephrine secretion" EXACT [] synonym: "down-regulation of epinephrine secretion" EXACT [] synonym: "downregulation of epinephrine secretion" EXACT [] synonym: "inhibition of epinephrine secretion" NARROW [] synonym: "negative regulation of adrenaline secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033604 ! negative regulation of catecholamine secretion is_a: GO:0046888 ! negative regulation of hormone secretion relationship: negatively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032812 name: positive regulation of epinephrine secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine." [GOC:vk] synonym: "activation of epinephrine secretion" NARROW [] synonym: "positive regulation of adrenaline secretion" EXACT [] synonym: "stimulation of epinephrine secretion" NARROW [] synonym: "up regulation of epinephrine secretion" EXACT [] synonym: "up-regulation of epinephrine secretion" EXACT [] synonym: "upregulation of epinephrine secretion" EXACT [] is_a: GO:0014060 ! regulation of epinephrine secretion is_a: GO:0033605 ! positive regulation of catecholamine secretion is_a: GO:0046887 ! positive regulation of hormone secretion relationship: positively_regulates GO:0048242 ! epinephrine secretion [Term] id: GO:0032813 name: tumor necrosis factor receptor superfamily binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the tumor necrosis factor receptor superfamily." [GOC:add] synonym: "TNF receptor superfamily binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0032814 name: regulation of natural killer cell activation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "regulation of NK cell activation" EXACT [] is_a: GO:0051249 ! regulation of lymphocyte activation relationship: regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032815 name: negative regulation of natural killer cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "down regulation of natural killer cell activation" EXACT [] synonym: "down-regulation of natural killer cell activation" EXACT [] synonym: "downregulation of natural killer cell activation" EXACT [] synonym: "inhibition of natural killer cell activation" NARROW [] synonym: "negative regulation of NK cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051250 ! negative regulation of lymphocyte activation relationship: negatively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032816 name: positive regulation of natural killer cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell activation." [GOC:mah] synonym: "activation of natural killer cell activation" NARROW [] synonym: "positive regulation of NK cell activation" EXACT [] synonym: "stimulation of natural killer cell activation" NARROW [] synonym: "up regulation of natural killer cell activation" EXACT [] synonym: "up-regulation of natural killer cell activation" EXACT [] synonym: "upregulation of natural killer cell activation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0051251 ! positive regulation of lymphocyte activation relationship: positively_regulates GO:0030101 ! natural killer cell activation [Term] id: GO:0032817 name: regulation of natural killer cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "regulation of NK cell proliferation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0050670 ! regulation of lymphocyte proliferation relationship: regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032818 name: negative regulation of natural killer cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "down regulation of natural killer cell proliferation" EXACT [] synonym: "down-regulation of natural killer cell proliferation" EXACT [] synonym: "downregulation of natural killer cell proliferation" EXACT [] synonym: "inhibition of natural killer cell proliferation" NARROW [] synonym: "negative regulation of NK cell proliferation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050672 ! negative regulation of lymphocyte proliferation relationship: negatively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032819 name: positive regulation of natural killer cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation." [GOC:mah] synonym: "activation of natural killer cell proliferation" NARROW [] synonym: "positive regulation of NK cell proliferation" EXACT [] synonym: "stimulation of natural killer cell proliferation" NARROW [] synonym: "up regulation of natural killer cell proliferation" EXACT [] synonym: "up-regulation of natural killer cell proliferation" EXACT [] synonym: "upregulation of natural killer cell proliferation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050671 ! positive regulation of lymphocyte proliferation relationship: positively_regulates GO:0001787 ! natural killer cell proliferation [Term] id: GO:0032820 name: regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032817 ! regulation of natural killer cell proliferation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032821 name: negative regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "down regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "down-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "downregulation of natural killer cell proliferation during immune response" RELATED [] synonym: "inhibition of natural killer cell proliferation during immune response" NARROW [] synonym: "negative regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell proliferation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032818 ! negative regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032822 name: positive regulation of natural killer cell proliferation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response." [GOC:mah] synonym: "activation of natural killer cell proliferation during immune response" NARROW [] synonym: "positive regulation of natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell proliferation during immune response" RELATED [] synonym: "stimulation of natural killer cell proliferation during immune response" NARROW [] synonym: "up regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "up-regulation of natural killer cell proliferation during immune response" RELATED [] synonym: "upregulation of natural killer cell proliferation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032819 ! positive regulation of natural killer cell proliferation is_a: GO:0032820 ! regulation of natural killer cell proliferation involved in immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002324 ! natural killer cell proliferation involved in immune response [Term] id: GO:0032823 name: regulation of natural killer cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development" RELATED [GOC:add] synonym: "regulation of NK cell differentiation" EXACT [] is_a: GO:0032814 ! regulation of natural killer cell activation is_a: GO:0045619 ! regulation of lymphocyte differentiation relationship: regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032824 name: negative regulation of natural killer cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation" EXACT [] synonym: "down-regulation of natural killer cell differentiation" EXACT [] synonym: "downregulation of natural killer cell differentiation" EXACT [] synonym: "inhibition of natural killer cell differentiation" NARROW [] synonym: "negative regulation of natural killer cell development" RELATED [GOC:add] synonym: "negative regulation of NK cell differentiation" EXACT [] is_a: GO:0032815 ! negative regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045620 ! negative regulation of lymphocyte differentiation relationship: negatively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032825 name: positive regulation of natural killer cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation" NARROW [] synonym: "positive regulation of natural killer cell development" RELATED [GOC:add] synonym: "positive regulation of NK cell differentiation" EXACT [] synonym: "stimulation of natural killer cell differentiation" NARROW [] synonym: "up regulation of natural killer cell differentiation" EXACT [] synonym: "up-regulation of natural killer cell differentiation" EXACT [] synonym: "upregulation of natural killer cell differentiation" EXACT [] is_a: GO:0032816 ! positive regulation of natural killer cell activation is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0045621 ! positive regulation of lymphocyte differentiation relationship: positively_regulates GO:0001779 ! natural killer cell differentiation [Term] id: GO:0032826 name: regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032823 ! regulation of natural killer cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032827 name: negative regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "down-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "downregulation of natural killer cell differentiation during immune response" RELATED [] synonym: "inhibition of natural killer cell differentiation during immune response" NARROW [] synonym: "negative regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of NK cell differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032824 ! negative regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032828 name: positive regulation of natural killer cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of natural killer cell differentiation during immune response" NARROW [] synonym: "positive regulation of natural killer cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of NK cell differentiation during immune response" RELATED [] synonym: "stimulation of natural killer cell differentiation during immune response" NARROW [] synonym: "up regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "up-regulation of natural killer cell differentiation during immune response" RELATED [] synonym: "upregulation of natural killer cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032825 ! positive regulation of natural killer cell differentiation is_a: GO:0032826 ! regulation of natural killer cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002325 ! natural killer cell differentiation involved in immune response [Term] id: GO:0032829 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043370 ! regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045589 ! regulation of regulatory T cell differentiation relationship: regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032830 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043371 ! negative regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045590 ! negative regulation of regulatory T cell differentiation relationship: negatively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032831 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation" EXACT [] is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0043372 ! positive regulation of CD4-positive, alpha-beta T cell differentiation is_a: GO:0045591 ! positive regulation of regulatory T cell differentiation relationship: positively_regulates GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0032832 name: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0032829 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032833 name: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "down regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "down-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "downregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "inhibition of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0032830 ! negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032834 name: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response." [GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "activation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell development involved in immune response" RELATED [GOC:add] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] synonym: "stimulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" NARROW [] synonym: "up regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "up-regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] synonym: "upregulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0032831 ! positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation is_a: GO:0032832 ! regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002298 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response [Term] id: GO:0032835 name: glomerulus development namespace: biological_process def: "The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment." [GOC:mah, GOC:mtg_kidney_jan10] synonym: "glomerular development" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0072006 ! nephron development [Term] id: GO:0032836 name: glomerular basement membrane development namespace: biological_process def: "The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration." [GOC:sr] is_a: GO:0030198 ! extracellular matrix organization is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0032835 ! glomerulus development [Term] id: GO:0032837 name: distributive segregation namespace: biological_process def: "The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a \"backup\" mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally." [GOC:expert_rsh, GOC:ma, GOC:sart] is_a: GO:0045132 ! meiotic chromosome segregation [Term] id: GO:0032838 name: plasma membrane bounded cell projection cytoplasm namespace: cellular_component def: "All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection." [GOC:krc, GOC:mah] is_a: GO:0099568 ! cytoplasmic region is_a: GO:0120038 ! plasma membrane bounded cell projection part [Term] id: GO:0032839 name: dendrite cytoplasm namespace: cellular_component def: "All of the contents of a dendrite, excluding the surrounding plasma membrane." [GOC:mah] synonym: "dendritic cytoplasm" EXACT [] is_a: GO:0120111 ! neuron projection cytoplasm relationship: part_of GO:0030425 ! dendrite [Term] id: GO:0032840 name: intramolecular proline-rich ligand binding namespace: molecular_function def: "Interacting selectively and non-covalently with a proline-rich region within the same polypeptide." [GOC:pf] synonym: "intramolecular proline-rich region binding" EXACT [] is_a: GO:0043621 ! protein self-association is_a: GO:0070064 ! proline-rich region binding [Term] id: GO:0032841 name: calcitonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid." [GOC:ecd] is_a: GO:0008144 ! drug binding is_a: GO:0097644 ! calcitonin family binding [Term] id: GO:0032843 name: hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol." [GOC:mlg, PMID:12540833] is_a: GO:0016671 ! oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor [Term] id: GO:0032847 name: regulation of cellular pH reduction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "regulation of cell pH reduction" EXACT [] synonym: "regulation of cellular acidification" EXACT [] synonym: "regulation of intracellular acidification" RELATED [] synonym: "regulation of intracellular pH reduction" EXACT [] synonym: "regulation of reduction of cellular pH" EXACT [] synonym: "regulation of reduction of pH in cell" EXACT [] is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051453 ! regulation of intracellular pH relationship: regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032848 name: negative regulation of cellular pH reduction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "down regulation of cellular pH reduction" EXACT [] synonym: "down-regulation of cellular pH reduction" EXACT [] synonym: "downregulation of cellular pH reduction" EXACT [] synonym: "inhibition of cellular pH reduction" NARROW [] synonym: "negative regulation of cell pH reduction" EXACT [] synonym: "negative regulation of cellular acidification" EXACT [] synonym: "negative regulation of intracellular acidification" RELATED [] synonym: "negative regulation of intracellular pH reduction" EXACT [] synonym: "negative regulation of reduction of cellular pH" EXACT [] synonym: "negative regulation of reduction of pH in cell" EXACT [] is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051454 ! intracellular pH elevation relationship: negatively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032849 name: positive regulation of cellular pH reduction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell." [GOC:mah] synonym: "activation of cellular pH reduction" NARROW [] synonym: "positive regulation of cell pH reduction" EXACT [] synonym: "positive regulation of cellular acidification" EXACT [] synonym: "positive regulation of intracellular acidification" RELATED [] synonym: "positive regulation of intracellular pH reduction" EXACT [] synonym: "positive regulation of reduction of cellular pH" EXACT [] synonym: "positive regulation of reduction of pH in cell" EXACT [] synonym: "stimulation of cellular pH reduction" NARROW [] synonym: "up regulation of cellular pH reduction" EXACT [] synonym: "up-regulation of cellular pH reduction" EXACT [] synonym: "upregulation of cellular pH reduction" EXACT [] is_a: GO:0032847 ! regulation of cellular pH reduction is_a: GO:0048522 ! positive regulation of cellular process relationship: positively_regulates GO:0051452 ! intracellular pH reduction [Term] id: GO:0032865 name: ERMES complex namespace: cellular_component def: "A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth." [GOC:mcc, PMID:19556461] synonym: "ER-mitochondria encounter structure" EXACT [] synonym: "Mdm10/Mdm12/Mmm1 complex" EXACT [] synonym: "mitochore" EXACT [GOC:mcc] synonym: "MMM1 complex" EXACT [GOC:mcc] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098799 ! outer mitochondrial membrane protein complex relationship: part_of GO:0044233 ! mitochondria-associated endoplasmic reticulum membrane [Term] id: GO:0032866 name: D-xylose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylitol + NADP+ = D-xylose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "D-xylose reductase activity" BROAD [] synonym: "xylose reductase activity" BROAD [] xref: EC:1.1.1 xref: MetaCyc:RXN-8773 xref: RHEA:27445 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032867 name: L-arabinose:NADP reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabitol + NADP+ = L-arabinose + NADPH + H+." [PMID:12724380, PMID:15184173] synonym: "arabinose reductase activity" BROAD [] synonym: "arabinose:NADP reductase activity" BROAD [] xref: EC:1.1.1 xref: KEGG:R01759 xref: MetaCyc:RXN-8772 xref: SABIO-RK:1858 is_a: GO:0004032 ! alditol:NADP+ 1-oxidoreductase activity [Term] id: GO:0032868 name: response to insulin namespace: biological_process def: "Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] synonym: "response to insulin stimulus" EXACT [GOC:dos] is_a: GO:0043434 ! response to peptide hormone [Term] id: GO:0032869 name: cellular response to insulin stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms." [GOC:mah, ISBN:0198506732] is_a: GO:0032868 ! response to insulin is_a: GO:0071375 ! cellular response to peptide hormone stimulus [Term] id: GO:0032870 name: cellular response to hormone stimulus namespace: biological_process def: "Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:mah] is_a: GO:0009725 ! response to hormone is_a: GO:0071310 ! cellular response to organic substance is_a: GO:0071495 ! cellular response to endogenous stimulus [Term] id: GO:0032871 name: regulation of karyogamy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion." [GOC:mah] is_a: GO:1903353 ! regulation of nucleus organization relationship: regulates GO:0000741 ! karyogamy [Term] id: GO:0032872 name: regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "regulation of p38 MAPK signaling" EXACT [] synonym: "regulation of p38 MAPK signalling" EXACT [] synonym: "regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0043408 ! regulation of MAPK cascade is_a: GO:0070302 ! regulation of stress-activated protein kinase signaling cascade relationship: regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032873 name: negative regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "down regulation of stress-activated MAPK cascade" EXACT [] synonym: "down-regulation of stress-activated MAPK cascade" EXACT [] synonym: "downregulation of stress-activated MAPK cascade" EXACT [] synonym: "inhibition of stress-activated MAPK cascade" NARROW [] synonym: "negative regulation of p38 MAPK signaling" EXACT [] synonym: "negative regulation of p38 MAPK signalling" EXACT [] synonym: "negative regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "negative regulation of stress-activated MAPKKK signalling pathway" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043409 ! negative regulation of MAPK cascade is_a: GO:0070303 ! negative regulation of stress-activated protein kinase signaling cascade relationship: negatively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032874 name: positive regulation of stress-activated MAPK cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade." [GOC:mah] synonym: "activation of stress-activated MAPK cascade" NARROW [] synonym: "positive regulation of p38 MAPK signaling" EXACT [] synonym: "positive regulation of p38 MAPK signalling" EXACT [] synonym: "positive regulation of stress-activated MAPK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPK signalling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK cascade" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signaling pathway" EXACT [] synonym: "positive regulation of stress-activated MAPKKK signalling pathway" EXACT [] synonym: "stimulation of stress-activated MAPK cascade" NARROW [] synonym: "up regulation of stress-activated MAPK cascade" EXACT [] synonym: "up-regulation of stress-activated MAPK cascade" EXACT [] synonym: "upregulation of stress-activated MAPK cascade" EXACT [] is_a: GO:0032872 ! regulation of stress-activated MAPK cascade is_a: GO:0043410 ! positive regulation of MAPK cascade is_a: GO:0070304 ! positive regulation of stress-activated protein kinase signaling cascade relationship: positively_regulates GO:0051403 ! stress-activated MAPK cascade [Term] id: GO:0032875 name: regulation of DNA endoreduplication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "regulation of DNA endoreplication" EXACT [] synonym: "regulation of DNA re-duplication" EXACT [] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0090329 ! regulation of DNA-dependent DNA replication relationship: regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032876 name: negative regulation of DNA endoreduplication namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "down regulation of DNA endoreduplication" EXACT [] synonym: "down-regulation of DNA endoreduplication" EXACT [] synonym: "downregulation of DNA endoreduplication" EXACT [] synonym: "inhibition of DNA endoreduplication" NARROW [] synonym: "negative regulation of DNA endoreplication" EXACT [] synonym: "negative regulation of DNA re-duplication" EXACT [] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:2000104 ! negative regulation of DNA-dependent DNA replication relationship: negatively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032877 name: positive regulation of DNA endoreduplication namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA endoreduplication." [GOC:mah] synonym: "activation of DNA endoreduplication" NARROW [] synonym: "positive regulation of DNA endoreplication" EXACT [] synonym: "positive regulation of DNA re-duplication" EXACT [] synonym: "stimulation of DNA endoreduplication" NARROW [] synonym: "up regulation of DNA endoreduplication" EXACT [] synonym: "up-regulation of DNA endoreduplication" EXACT [] synonym: "upregulation of DNA endoreduplication" EXACT [] is_a: GO:0032875 ! regulation of DNA endoreduplication is_a: GO:0090068 ! positive regulation of cell cycle process is_a: GO:2000105 ! positive regulation of DNA-dependent DNA replication relationship: positively_regulates GO:0042023 ! DNA endoreduplication [Term] id: GO:0032878 name: regulation of establishment or maintenance of cell polarity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007163 ! establishment or maintenance of cell polarity [Term] id: GO:0032879 name: regulation of localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location." [GOC:mah] synonym: "regulation of localisation" EXACT [GOC:mah] is_a: GO:0050789 ! regulation of biological process relationship: regulates GO:0051179 ! localization [Term] id: GO:0032880 name: regulation of protein localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_chembl synonym: "regulation of protein localisation" EXACT [GOC:mah] is_a: GO:0032879 ! regulation of localization relationship: regulates GO:0008104 ! protein localization [Term] id: GO:0032881 name: regulation of polysaccharide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides." [GOC:mah] is_a: GO:0006109 ! regulation of carbohydrate metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process relationship: regulates GO:0005976 ! polysaccharide metabolic process [Term] id: GO:0032882 name: regulation of chitin metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin." [GOC:mah] synonym: "regulation of chitin metabolism" EXACT [] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0051171 ! regulation of nitrogen compound metabolic process relationship: regulates GO:0006030 ! chitin metabolic process [Term] id: GO:0032883 name: regulation of chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin." [GOC:mah] synonym: "regulation of chitin anabolism" EXACT [] synonym: "regulation of chitin biosynthesis" RELATED [] synonym: "regulation of chitin formation" EXACT [] synonym: "regulation of chitin synthesis" EXACT [] is_a: GO:0032882 ! regulation of chitin metabolic process is_a: GO:0032885 ! regulation of polysaccharide biosynthetic process relationship: regulates GO:0006031 ! chitin biosynthetic process [Term] id: GO:0032884 name: regulation of cell wall chitin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin." [GOC:mah] synonym: "regulation of cell wall chitin anabolism" EXACT [] synonym: "regulation of cell wall chitin biosynthesis" EXACT [] synonym: "regulation of cell wall chitin formation" EXACT [] synonym: "regulation of cell wall chitin synthesis" EXACT [] is_a: GO:0032883 ! regulation of chitin biosynthetic process is_a: GO:0034222 ! regulation of cell wall chitin metabolic process is_a: GO:0044087 ! regulation of cellular component biogenesis relationship: regulates GO:0006038 ! cell wall chitin biosynthetic process [Term] id: GO:0032885 name: regulation of polysaccharide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides." [GOC:mah] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process relationship: regulates GO:0000271 ! polysaccharide biosynthetic process [Term] id: GO:0032886 name: regulation of microtubule-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0007017 ! microtubule-based process [Term] id: GO:0032887 name: regulation of spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle." [GOC:mah] is_a: GO:0051983 ! regulation of chromosome segregation is_a: GO:0090224 ! regulation of spindle organization relationship: regulates GO:0051231 ! spindle elongation [Term] id: GO:0032888 name: regulation of mitotic spindle elongation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle." [GOC:mah] is_a: GO:0032887 ! regulation of spindle elongation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0060236 ! regulation of mitotic spindle organization relationship: regulates GO:0000022 ! mitotic spindle elongation [Term] id: GO:0032889 name: regulation of vacuole fusion, non-autophagic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole." [GOC:mah] is_a: GO:0044088 ! regulation of vacuole organization relationship: regulates GO:0042144 ! vacuole fusion, non-autophagic [Term] id: GO:0032890 name: regulation of organic acid transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] is_a: GO:0051049 ! regulation of transport relationship: regulates GO:0015849 ! organic acid transport [Term] id: GO:0032891 name: negative regulation of organic acid transport namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "down regulation of organic acid transport" EXACT [] synonym: "down-regulation of organic acid transport" EXACT [] synonym: "downregulation of organic acid transport" EXACT [] synonym: "inhibition of organic acid transport" NARROW [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051051 ! negative regulation of transport relationship: negatively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032892 name: positive regulation of organic acid transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore." [GOC:mah] synonym: "activation of organic acid transport" NARROW [] synonym: "stimulation of organic acid transport" NARROW [] synonym: "up regulation of organic acid transport" EXACT [] synonym: "up-regulation of organic acid transport" EXACT [] synonym: "upregulation of organic acid transport" EXACT [] is_a: GO:0032890 ! regulation of organic acid transport is_a: GO:0051050 ! positive regulation of transport relationship: positively_regulates GO:0015849 ! organic acid transport [Term] id: GO:0032896 name: palmitoyl-CoA 9-desaturase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + AH2 + O2 = palmitoleic acid (16:1delta9) + A + 2 H2O." [GOC:kmv] synonym: "palmitoyl-CoA delta9-desaturase acitivity" EXACT [] is_a: GO:0016215 ! acyl-CoA desaturase activity [Term] id: GO:0032897 name: negative regulation of viral transcription namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of viral transcription." [GOC:mah] synonym: "down regulation of viral transcription" EXACT [] synonym: "down-regulation of viral transcription" EXACT [] synonym: "downregulation of viral transcription" EXACT [] synonym: "inhibition of viral transcription" NARROW [] is_a: GO:0046782 ! regulation of viral transcription is_a: GO:0048525 ! negative regulation of viral process relationship: negatively_regulates GO:0019083 ! viral transcription [Term] id: GO:0032898 name: neurotrophin production namespace: biological_process def: "The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth." [GOC:ecd, GOC:mah, GOC:mtg_MIT_16mar07] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032899 name: regulation of neurotrophin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] is_a: GO:0051239 ! regulation of multicellular organismal process relationship: regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032900 name: negative regulation of neurotrophin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "down regulation of neurotrophin production" EXACT [] synonym: "down-regulation of neurotrophin production" EXACT [] synonym: "downregulation of neurotrophin production" EXACT [] synonym: "inhibition of neurotrophin production" NARROW [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051241 ! negative regulation of multicellular organismal process relationship: negatively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032901 name: positive regulation of neurotrophin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin." [GOC:mah] synonym: "activation of neurotrophin production" NARROW [] synonym: "stimulation of neurotrophin production" NARROW [] synonym: "up regulation of neurotrophin production" EXACT [] synonym: "up-regulation of neurotrophin production" EXACT [] synonym: "upregulation of neurotrophin production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production is_a: GO:0051240 ! positive regulation of multicellular organismal process relationship: positively_regulates GO:0032898 ! neurotrophin production [Term] id: GO:0032902 name: nerve growth factor production namespace: biological_process def: "The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels." [GOC:ecd, GOC:mah] synonym: "beta-nerve growth factor production" EXACT [PR:000011194] synonym: "NGF production" EXACT [] is_a: GO:0032898 ! neurotrophin production [Term] id: GO:0032903 name: regulation of nerve growth factor production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] synonym: "regulation of beta-nerve growth factor production" EXACT [PR:000011194] synonym: "regulation of NGF production" EXACT [] is_a: GO:0032899 ! regulation of neurotrophin production relationship: regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032904 name: negative regulation of nerve growth factor production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF)." [GOC:mah] synonym: "down regulation of nerve growth factor production" EXACT [] synonym: "down-regulation of nerve growth factor production" EXACT [] synonym: "downregulation of nerve growth factor production" EXACT [] synonym: "inhibition of nerve growth factor production" NARROW [] synonym: "negative regulation of NGF production" EXACT [] is_a: GO:0032900 ! negative regulation of neurotrophin production is_a: GO:0032903 ! regulation of nerve growth factor production relationship: negatively_regulates GO:0032902 ! nerve growth factor production [Term] id: GO:0032905 name: transforming growth factor beta1 production namespace: biological_process def: "The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B1 production" EXACT [] synonym: "TGFB1 production" EXACT [] synonym: "transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032906 name: transforming growth factor beta2 production namespace: biological_process def: "The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B2 production" EXACT [] synonym: "TGFB2 production" EXACT [] synonym: "transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032907 name: transforming growth factor beta3 production namespace: biological_process def: "The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:mah] synonym: "TGF-B3 production" EXACT [] synonym: "TGFB3 production" EXACT [] synonym: "transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0071604 ! transforming growth factor beta production [Term] id: GO:0032908 name: regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "regulation of TGF-B1 production" EXACT [] synonym: "regulation of TGFB1 production" EXACT [] synonym: "regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production relationship: regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032909 name: regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "regulation of TGF-B2 production" EXACT [] synonym: "regulation of TGFB2 production" EXACT [] synonym: "regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production relationship: regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032910 name: regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "regulation of TGF-B3 production" EXACT [] synonym: "regulation of TGFB3 production" EXACT [] synonym: "regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0071634 ! regulation of transforming growth factor beta production relationship: regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032911 name: negative regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "down regulation of transforming growth factor-beta1 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "downregulation of transforming growth factor-beta1 production" EXACT [] synonym: "inhibition of transforming growth factor-beta1 production" NARROW [] synonym: "negative regulation of TGF-B1 production" EXACT [] synonym: "negative regulation of TGFB1 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta1 production" EXACT [GOC:bf] is_a: GO:0032908 ! regulation of transforming growth factor beta1 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production relationship: negatively_regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032912 name: negative regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "down regulation of transforming growth factor-beta2 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "downregulation of transforming growth factor-beta2 production" EXACT [] synonym: "inhibition of transforming growth factor-beta2 production" NARROW [] synonym: "negative regulation of TGF-B2 production" EXACT [] synonym: "negative regulation of TGFB2 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] is_a: GO:0032909 ! regulation of transforming growth factor beta2 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production relationship: negatively_regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032913 name: negative regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "down regulation of transforming growth factor-beta3 production" EXACT [] synonym: "down-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "downregulation of transforming growth factor-beta3 production" EXACT [] synonym: "inhibition of transforming growth factor-beta3 production" NARROW [] synonym: "negative regulation of TGF-B3 production" EXACT [] synonym: "negative regulation of TGFB3 production" EXACT [] synonym: "negative regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] is_a: GO:0032910 ! regulation of transforming growth factor beta3 production is_a: GO:0071635 ! negative regulation of transforming growth factor beta production relationship: negatively_regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032914 name: positive regulation of transforming growth factor beta1 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1." [GOC:mah] synonym: "activation of transforming growth factor-beta1 production" NARROW [GOC:bf] synonym: "positive regulation of TGF-B1 production" EXACT [] synonym: "positive regulation of TGFB1 production" EXACT [] synonym: "stimulation of transforming growth factor-beta1 production" NARROW [] synonym: "up regulation of transforming growth factor-beta1 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta1 production" EXACT [] synonym: "upregulation of transforming growth factor-beta1 production" EXACT [] is_a: GO:0032908 ! regulation of transforming growth factor beta1 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production relationship: positively_regulates GO:0032905 ! transforming growth factor beta1 production [Term] id: GO:0032915 name: positive regulation of transforming growth factor beta2 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2." [GOC:mah] synonym: "activation of transforming growth factor-beta2 production" NARROW [] synonym: "positive regulation of TGF-B2 production" EXACT [] synonym: "positive regulation of TGFB2 production" EXACT [] synonym: "positive regulation of transforming growth factor-beta2 production" EXACT [GOC:bf] synonym: "stimulation of transforming growth factor-beta2 production" NARROW [] synonym: "up regulation of transforming growth factor-beta2 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta2 production" EXACT [] synonym: "upregulation of transforming growth factor-beta2 production" EXACT [] is_a: GO:0032909 ! regulation of transforming growth factor beta2 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production relationship: positively_regulates GO:0032906 ! transforming growth factor beta2 production [Term] id: GO:0032916 name: positive regulation of transforming growth factor beta3 production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3." [GOC:mah] synonym: "activation of transforming growth factor-beta3 production" NARROW [] synonym: "positive regulation of TGF-B3 production" EXACT [] synonym: "positive regulation of TGFB3 production" EXACT [] synonym: "positive regulation of transforming growth factor-beta3 production" EXACT [GOC:bf] synonym: "stimulation of transforming growth factor-beta3 production" NARROW [] synonym: "up regulation of transforming growth factor-beta3 production" EXACT [] synonym: "up-regulation of transforming growth factor-beta3 production" EXACT [] synonym: "upregulation of transforming growth factor-beta3 production" EXACT [] is_a: GO:0032910 ! regulation of transforming growth factor beta3 production is_a: GO:0071636 ! positive regulation of transforming growth factor beta production relationship: positively_regulates GO:0032907 ! transforming growth factor beta3 production [Term] id: GO:0032917 name: polyamine acetylation namespace: biological_process def: "The modification of polyamines by addition of acetyl groups." [GOC:mlg] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0032918 name: spermidine acetylation namespace: biological_process def: "The modification of spermidine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008216 ! spermidine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032919 name: spermine acetylation namespace: biological_process def: "The modification of spermine by addition of acetyl groups." [GOC:mlg] is_a: GO:0008215 ! spermine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032920 name: putrescine acetylation namespace: biological_process def: "The modification of putrescine by addition of acetyl groups." [GOC:mlg] is_a: GO:0009445 ! putrescine metabolic process is_a: GO:0032917 ! polyamine acetylation [Term] id: GO:0032921 name: sarcosine oxidase complex namespace: cellular_component def: "A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity." [GOC:mah, GOC:mlg] is_a: GO:0044444 ! cytoplasmic part is_a: GO:1990204 ! oxidoreductase complex [Term] id: GO:0032922 name: circadian regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours." [GOC:mah] synonym: "circadian regulation of protein expression" RELATED [] synonym: "diurnal variation of gene expression" RELATED [] synonym: "diurnal variation of protein expression" RELATED [] is_a: GO:0007623 ! circadian rhythm is_a: GO:0010468 ! regulation of gene expression is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0032923 name: organic phosphonate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included." [GOC:js] synonym: "organophosphonate biosynthetic process" RELATED [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0032924 name: activin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an activin receptor on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription." [GOC:rl, GOC:signaling] synonym: "activin receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0032925 name: regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "regulation of activin receptor signalling pathway" EXACT [] synonym: "regulation of activin signaling pathway" RELATED [] synonym: "regulation of activin signalling pathway" RELATED [] is_a: GO:0090092 ! regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032926 name: negative regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "down regulation of activin receptor signaling pathway" EXACT [] synonym: "down-regulation of activin receptor signaling pathway" EXACT [] synonym: "downregulation of activin receptor signaling pathway" EXACT [] synonym: "inhibition of activin receptor signaling pathway" NARROW [] synonym: "negative regulation of activin receptor signalling pathway" EXACT [] synonym: "negative regulation of activin signaling pathway" RELATED [] synonym: "negative regulation of activin signalling pathway" RELATED [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090101 ! negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: negatively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032927 name: positive regulation of activin receptor signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway." [GOC:BHF, GOC:rl] synonym: "activation of activin receptor signaling pathway" NARROW [] synonym: "positive regulation of activin receptor signalling pathway" EXACT [] synonym: "positive regulation of activin signaling pathway" RELATED [] synonym: "positive regulation of activin signalling pathway" RELATED [] synonym: "stimulation of activin receptor signaling pathway" NARROW [] synonym: "up regulation of activin receptor signaling pathway" EXACT [] synonym: "up-regulation of activin receptor signaling pathway" EXACT [] synonym: "upregulation of activin receptor signaling pathway" EXACT [] is_a: GO:0032925 ! regulation of activin receptor signaling pathway is_a: GO:0090100 ! positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway relationship: positively_regulates GO:0032924 ! activin receptor signaling pathway [Term] id: GO:0032928 name: regulation of superoxide anion generation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0090322 ! regulation of superoxide metabolic process relationship: regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032929 name: negative regulation of superoxide anion generation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "down regulation of superoxide release" EXACT [] synonym: "down-regulation of superoxide release" EXACT [] synonym: "downregulation of superoxide release" EXACT [] synonym: "inhibition of superoxide release" NARROW [] synonym: "negative regulation of superoxide release" EXACT [GOC:dph, GOC:tb] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000378 ! negative regulation of reactive oxygen species metabolic process relationship: negatively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032930 name: positive regulation of superoxide anion generation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell." [GOC:mah] synonym: "activation of superoxide release" NARROW [] synonym: "positive regulation of superoxide release" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of superoxide release" NARROW [] synonym: "up regulation of superoxide release" EXACT [] synonym: "up-regulation of superoxide release" EXACT [] synonym: "upregulation of superoxide release" EXACT [] is_a: GO:0032928 ! regulation of superoxide anion generation is_a: GO:2000379 ! positive regulation of reactive oxygen species metabolic process relationship: positively_regulates GO:0042554 ! superoxide anion generation [Term] id: GO:0032931 name: histone acetyltransferase activity (H3-K56 specific) namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56)." [EC:2.3.1.48] synonym: "histone lysine N-acetyltransferase activity (H3-K56 specific)" EXACT [] is_a: GO:0010484 ! H3 histone acetyltransferase activity [Term] id: GO:0032932 name: negative regulation of astral microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules." [GOC:mah] synonym: "astral microtubule stabilization" EXACT [] is_a: GO:0007026 ! negative regulation of microtubule depolymerization is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0090224 ! regulation of spindle organization relationship: negatively_regulates GO:0060172 ! astral microtubule depolymerization [Term] id: GO:0032933 name: SREBP signaling pathway namespace: biological_process alt_id: GO:0006994 alt_id: GO:0030967 alt_id: GO:0035104 def: "A series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription." [GOC:bf, GOC:mah, GOC:signaling, GOC:vw, PMID:12923525, PMID:22017871] synonym: "activation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "endoplasmic reticulum to nucleus sterol response pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear sterol response pathway" EXACT [] synonym: "ER to nucleus sterol response pathway" EXACT [] synonym: "ER-nuclear sterol response pathway" EXACT [] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of transcription via sterol regulatory element binding" NARROW [GOC:vw] synonym: "positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway" NARROW [GOC:vw] synonym: "SREBP signalling" EXACT [GOC:bf] synonym: "SREBP target gene transcriptional activation" EXACT [] synonym: "SREBP-mediated signaling pathway" RELATED [] synonym: "SREBP-mediated signalling pathway" EXACT [] synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] synonym: "sterol regulatory element binding protein target gene transcriptional activation" BROAD [] synonym: "sterol response element binding protein signaling pathway" EXACT [GOC:bf] synonym: "stimulation of sterol regulatory element binding protein target gene transcription" NARROW [] synonym: "up regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "up-regulation of sterol regulatory element binding protein target gene transcription" EXACT [] synonym: "upregulation of sterol regulatory element binding protein target gene transcription" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II is_a: GO:0071501 ! cellular response to sterol depletion [Term] id: GO:0032934 name: sterol binding namespace: molecular_function alt_id: GO:0005498 def: "Interacting selectively and non-covalently with a sterol, any steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol." [CHEBI:15889, GOC:mah] synonym: "sterol carrier activity" RELATED [GOC:mah] is_a: GO:0005496 ! steroid binding [Term] id: GO:0032935 name: sterol sensor activity namespace: molecular_function def: "Interacting selectively and non-covalently with and responding, e.g. by conformational change, to changes in the cellular level of a sterol." [GOC:mah] synonym: "sterol-sensing domain" NARROW [] is_a: GO:0032934 ! sterol binding is_a: GO:0140299 ! small molecule sensor activity [Term] id: GO:0032936 name: SREBP-SCAP complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed." [PMID:12923525] synonym: "Sre1-Scp1 complex" EXACT [] is_a: GO:0098796 ! membrane protein complex [Term] id: GO:0032937 name: SREBP-SCAP-Insig complex namespace: cellular_component def: "A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane." [PMID:12923525] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0030176 ! integral component of endoplasmic reticulum membrane [Term] id: GO:0032938 name: negative regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] is_a: GO:0032055 ! negative regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032939 name: positive regulation of translation in response to oxidative stress namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:mah] synonym: "activation of translation in response to oxidative stress" NARROW [] synonym: "stimulation of translation in response to oxidative stress" NARROW [] synonym: "up regulation of translation in response to oxidative stress" EXACT [] synonym: "up-regulation of translation in response to oxidative stress" EXACT [] synonym: "upregulation of translation in response to oxidative stress" EXACT [] is_a: GO:0032056 ! positive regulation of translation in response to stress is_a: GO:0043556 ! regulation of translation in response to oxidative stress [Term] id: GO:0032940 name: secretion by cell namespace: biological_process def: "The controlled release of a substance by a cell." [GOC:mah] synonym: "cellular secretion" EXACT [] xref: Wikipedia:Secretion is_a: GO:0009987 ! cellular process is_a: GO:0046903 ! secretion [Term] id: GO:0032941 name: secretion by tissue namespace: biological_process def: "The controlled release of a substance by a tissue." [GOC:mah] synonym: "expulsion of gland contents" RELATED [GOC:mah] synonym: "tissue secretion" EXACT [] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0046903 ! secretion [Term] id: GO:0032942 name: inositol tetrakisphosphate 2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP." [GOC:hf] synonym: "1D-myo-inositol-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol 1,3,4,6-tetrakisphosphate 2-kinase activity" EXACT [] synonym: "inositol-tetrakisphosphate 2-kinase activity" EXACT [] xref: EC:2.7.1 is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0032943 name: mononuclear cell proliferation namespace: biological_process def: "The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form." [GOC:add] synonym: "PBMC proliferation" NARROW [] synonym: "peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070661 ! leukocyte proliferation [Term] id: GO:0032944 name: regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "regulation of PBMC proliferation" NARROW [] synonym: "regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0070663 ! regulation of leukocyte proliferation relationship: regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032945 name: negative regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "negative regulation of PBMC proliferation" NARROW [] synonym: "negative regulation of peripheral blood mononuclear cell proliferation" NARROW [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070664 ! negative regulation of leukocyte proliferation relationship: negatively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032946 name: positive regulation of mononuclear cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation." [GOC:add] synonym: "activation of mononuclear cell proliferation" NARROW [] synonym: "positive regulation of PBMC proliferation" NARROW [] synonym: "positive regulation of peripheral blood mononuclear cell proliferation" NARROW [] synonym: "stimulation of mononuclear cell proliferation" NARROW [] synonym: "up regulation of mononuclear cell proliferation" EXACT [] synonym: "up-regulation of mononuclear cell proliferation" EXACT [] synonym: "upregulation of mononuclear cell proliferation" EXACT [] is_a: GO:0032944 ! regulation of mononuclear cell proliferation is_a: GO:0070665 ! positive regulation of leukocyte proliferation relationship: positively_regulates GO:0032943 ! mononuclear cell proliferation [Term] id: GO:0032948 name: regulation of alpha-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans." [GOC:mah] synonym: "regulation of alpha-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process relationship: regulates GO:0030978 ! alpha-glucan metabolic process [Term] id: GO:0032949 name: regulation of alpha-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans." [GOC:mah] synonym: "regulation of alpha-glucan anabolism" EXACT [] synonym: "regulation of alpha-glucan biosynthesis" EXACT [] synonym: "regulation of alpha-glucan formation" EXACT [] synonym: "regulation of alpha-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032948 ! regulation of alpha-glucan metabolic process relationship: regulates GO:0030979 ! alpha-glucan biosynthetic process [Term] id: GO:0032950 name: regulation of beta-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans." [GOC:mah] synonym: "regulation of beta-glucan metabolism" EXACT [] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0032881 ! regulation of polysaccharide metabolic process relationship: regulates GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0032951 name: regulation of beta-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans." [GOC:mah] synonym: "regulation of beta-glucan anabolism" EXACT [] synonym: "regulation of beta-glucan biosynthesis" EXACT [] synonym: "regulation of beta-glucan formation" EXACT [] synonym: "regulation of beta-glucan synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0032950 ! regulation of beta-glucan metabolic process relationship: regulates GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0032952 name: regulation of (1->3)-beta-D-glucan metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans." [GOC:mah] synonym: "regulation of (1->3)-beta-D-glucan metabolism" EXACT [] synonym: "regulation of 1,3-beta-D-glucan metabolic process" EXACT [] synonym: "regulation of 1,3-beta-glucan metabolic process" BROAD [] synonym: "regulation of 1,3-beta-glucan metabolism" EXACT [] is_a: GO:0032950 ! regulation of beta-glucan metabolic process relationship: regulates GO:0006074 ! (1->3)-beta-D-glucan metabolic process [Term] id: GO:0032953 name: regulation of (1->3)-beta-D-glucan biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans." [GOC:mah] synonym: "regulation of 1,3-beta-glucan anabolism" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthesis" EXACT [] synonym: "regulation of 1,3-beta-glucan biosynthetic process" BROAD [] synonym: "regulation of 1,3-beta-glucan formation" EXACT [] synonym: "regulation of 1,3-beta-glucan synthesis" EXACT [] is_a: GO:0032951 ! regulation of beta-glucan biosynthetic process is_a: GO:0032952 ! regulation of (1->3)-beta-D-glucan metabolic process relationship: regulates GO:0006075 ! (1->3)-beta-D-glucan biosynthetic process [Term] id: GO:0032954 name: regulation of cytokinetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a cytokinetic process." [GOC:mah] is_a: GO:0032465 ! regulation of cytokinesis relationship: regulates GO:0032506 ! cytokinetic process [Term] id: GO:0032955 name: regulation of division septum assembly namespace: biological_process alt_id: GO:1901138 alt_id: GO:1902468 def: "Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis." [GOC:mtg_cell_cycle, PMID:19959363, PMID:21246752, PMID:22786806] synonym: "regulation of division septum formation" EXACT [] is_a: GO:1901891 ! regulation of cell septum assembly relationship: regulates GO:0000917 ! division septum assembly [Term] id: GO:0032956 name: regulation of actin cytoskeleton organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins." [GOC:mah] synonym: "regulation of actin cytoskeleton organisation" EXACT [GOC:mah] synonym: "regulation of actin cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0032970 ! regulation of actin filament-based process is_a: GO:0051493 ! regulation of cytoskeleton organization relationship: regulates GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0032957 name: inositol trisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24540, CHEBI:24848, GOC:mah] synonym: "inositol trisphosphate metabolism" EXACT [] synonym: "IP3 metabolic process" EXACT [] synonym: "IP3 metabolism" EXACT [] synonym: "myo-inositol trisphosphate metabolic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process [Term] id: GO:0032958 name: inositol phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached." [CHEBI:24848, CHEBI:25448, GOC:mah] synonym: "inositol phosphate anabolism" EXACT [] synonym: "inositol phosphate biosynthesis" EXACT [] synonym: "inositol phosphate formation" EXACT [] synonym: "inositol phosphate synthesis" EXACT [] synonym: "myo-inositol phosphate biosynthetic process" NARROW [] is_a: GO:0043647 ! inositol phosphate metabolic process is_a: GO:0046173 ! polyol biosynthetic process is_a: GO:0090407 ! organophosphate biosynthetic process [Term] id: GO:0032959 name: inositol trisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached." [CHEBI:24848, CHEBI:25450, GOC:mah] synonym: "inositol trisphosphate anabolism" EXACT [] synonym: "inositol trisphosphate biosynthesis" EXACT [] synonym: "inositol trisphosphate formation" EXACT [] synonym: "inositol trisphosphate synthesis" EXACT [] synonym: "IP3 biosynthesis" EXACT [] synonym: "IP3 biosynthetic process" EXACT [] synonym: "myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032957 ! inositol trisphosphate metabolic process is_a: GO:0032958 ! inositol phosphate biosynthetic process [Term] id: GO:0032960 name: regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "regulation of inositol trisphosphate anabolism" EXACT [] synonym: "regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "regulation of inositol trisphosphate formation" EXACT [] synonym: "regulation of inositol trisphosphate synthesis" EXACT [] synonym: "regulation of IP3 biosynthesis" EXACT [] synonym: "regulation of IP3 biosynthetic process" EXACT [] synonym: "regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010919 ! regulation of inositol phosphate biosynthetic process relationship: regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032961 name: negative regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "negative regulation of inositol trisphosphate anabolism" EXACT [] synonym: "negative regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "negative regulation of inositol trisphosphate formation" EXACT [] synonym: "negative regulation of inositol trisphosphate synthesis" EXACT [] synonym: "negative regulation of IP3 biosynthesis" EXACT [] synonym: "negative regulation of IP3 biosynthetic process" EXACT [] synonym: "negative regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "negative regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0010920 ! negative regulation of inositol phosphate biosynthetic process is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process relationship: negatively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032962 name: positive regulation of inositol trisphosphate biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate." [GOC:mah] synonym: "positive regulation of inositol trisphosphate anabolism" EXACT [] synonym: "positive regulation of inositol trisphosphate biosynthesis" EXACT [] synonym: "positive regulation of inositol trisphosphate formation" EXACT [] synonym: "positive regulation of inositol trisphosphate synthesis" EXACT [] synonym: "positive regulation of IP3 biosynthesis" EXACT [] synonym: "positive regulation of IP3 biosynthetic process" EXACT [] synonym: "positive regulation of myo-inositol trisphosphate biosynthesis" NARROW [] synonym: "positive regulation of myo-inositol trisphosphate biosynthetic process" NARROW [] is_a: GO:0032960 ! regulation of inositol trisphosphate biosynthetic process is_a: GO:0060732 ! positive regulation of inositol phosphate biosynthetic process relationship: positively_regulates GO:0032959 ! inositol trisphosphate biosynthetic process [Term] id: GO:0032963 name: collagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0032964 name: collagen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:mah, ISBN:0198506732] synonym: "collagen anabolism" EXACT [] synonym: "collagen biosynthesis" EXACT [] synonym: "collagen formation" EXACT [] synonym: "collagen synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0032963 ! collagen metabolic process [Term] id: GO:0032965 name: regulation of collagen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "regulation of collagen anabolism" EXACT [] synonym: "regulation of collagen biosynthesis" EXACT [] synonym: "regulation of collagen formation" EXACT [] synonym: "regulation of collagen synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0010712 ! regulation of collagen metabolic process relationship: regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032966 name: negative regulation of collagen biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "negative regulation of collagen anabolism" EXACT [] synonym: "negative regulation of collagen biosynthesis" EXACT [] synonym: "negative regulation of collagen formation" EXACT [] synonym: "negative regulation of collagen synthesis" EXACT [] is_a: GO:0009890 ! negative regulation of biosynthetic process is_a: GO:0010713 ! negative regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process relationship: negatively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032967 name: positive regulation of collagen biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals." [GOC:mah] synonym: "positive regulation of collagen anabolism" EXACT [] synonym: "positive regulation of collagen biosynthesis" EXACT [] synonym: "positive regulation of collagen formation" EXACT [] synonym: "positive regulation of collagen synthesis" EXACT [] is_a: GO:0009891 ! positive regulation of biosynthetic process is_a: GO:0010714 ! positive regulation of collagen metabolic process is_a: GO:0032965 ! regulation of collagen biosynthetic process relationship: positively_regulates GO:0032964 ! collagen biosynthetic process [Term] id: GO:0032968 name: positive regulation of transcription elongation from RNA polymerase II promoter namespace: biological_process alt_id: GO:0090040 def: "Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II." [GOC:mah, GOC:txnOH] synonym: "positive regulation of gene-specific transcription elongation from RNA polymerase II promoter" RELATED [] synonym: "positive regulation of RNA elongation from RNA polymerase II promoter" EXACT [] is_a: GO:0032786 ! positive regulation of DNA-templated transcription, elongation is_a: GO:0034243 ! regulation of transcription elongation from RNA polymerase II promoter is_a: GO:0045944 ! positive regulation of transcription by RNA polymerase II relationship: positively_regulates GO:0006368 ! transcription elongation from RNA polymerase II promoter [Term] id: GO:0032969 name: endosomal scaffold complex namespace: cellular_component def: "A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling." [PMID:15263099, PMID:16227978, PMID:17496910] synonym: "endosomal adaptor complex" EXACT [GOC:hjd] synonym: "MP1-p14 scaffolding complex" EXACT [GOC:mah] is_a: GO:0044440 ! endosomal part is_a: GO:0098796 ! membrane protein complex relationship: part_of GO:0031902 ! late endosome membrane [Term] id: GO:0032970 name: regulation of actin filament-based process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton." [GOC:mah] is_a: GO:0050794 ! regulation of cellular process relationship: regulates GO:0030029 ! actin filament-based process [Term] id: GO:0032971 name: regulation of muscle filament sliding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle filament sliding." [GOC:ecd] is_a: GO:0006937 ! regulation of muscle contraction is_a: GO:0032386 ! regulation of intracellular transport is_a: GO:1903115 ! regulation of actin filament-based movement relationship: regulates GO:0030049 ! muscle filament sliding [Term] id: GO:0032972 name: regulation of muscle filament sliding speed namespace: biological_process def: "Any process that modulates the velocity of muscle filament sliding." [GOC:dph, GOC:ecd, GOC:tb] is_a: GO:0032971 ! regulation of muscle filament sliding is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0032973 name: amino acid export across plasma membrane namespace: biological_process alt_id: GO:0044746 def: "The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region." [GOC:jl] synonym: "amino acid efflux" EXACT [] synonym: "amino acid export" BROAD [] synonym: "amino acid transmembrane export" BROAD [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0140115 ! export across plasma membrane [Term] id: GO:0032974 name: amino acid transmembrane export from vacuole namespace: biological_process def: "The directed movement of amino acids out of the vacuole, across the vacuolar membrane." [GOC:mah] synonym: "amino acid efflux from vacuole" EXACT [] synonym: "vacuolar amino acid export" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport [Term] id: GO:0032975 name: amino acid transmembrane import into vacuole namespace: biological_process def: "The directed movement of amino acids into the vacuole across the vacuolar membrane." [GOC:mah] synonym: "vacuolar amino acid import" EXACT [] is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0034486 ! vacuolar transmembrane transport is_a: GO:0043090 ! amino acid import [Term] id: GO:0032976 name: release of matrix enzymes from mitochondria namespace: biological_process def: "The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process." [GOC:mah, GOC:mtg_apoptosis, PMID:9843949] comment: Annotation to this term should be done with caution, particularly if the mechanism is not well clarified. synonym: "mAST release from mitochondria" NARROW [] synonym: "release of aspartate aminotransferase from mitochondria" NARROW [] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0032977 name: membrane insertase activity namespace: molecular_function def: "Mediates the integration of proteins into a membrane from the inner side of the membrane. Membrane insertases are highly conserved and include the bacterial YidC family, the plant chloroplast Alb3 family, and the fungal and animal mitochondrial Oxa1/Cox18 family." [PMID:14739936] comment: Changed parent to 'molecular carrier activity', see https://github.com/geneontology/go-ontology/issues/16976 xref: reactome:R-HSA-1268025 "SAM50 complex inserts proteins into mitochondrial outer membrane" xref: reactome:R-HSA-1299482 "TIMM23 SORT inserts proteins into inner membrane" xref: reactome:R-HSA-1307803 "TIMM22 inserts proteins into inner membrane" is_a: GO:0140104 ! molecular carrier activity [Term] id: GO:0032978 name: protein insertion into membrane from inner side namespace: biological_process def: "The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side." [PMID:14739936, PMID:15473843] synonym: "insertion of proteins into membrane from the inner side" EXACT [] is_a: GO:0051205 ! protein insertion into membrane [Term] id: GO:0032979 name: protein insertion into mitochondrial inner membrane from matrix namespace: biological_process def: "The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix." [GOC:vw, PMID:12880202, PMID:15473843] synonym: "insertion of proteins into the mitochondrial membrane from the inner side" EXACT [] synonym: "protein insertion into mitochondrial inner membrane from matrix side" EXACT [] synonym: "protein insertion into mitochondrial membrane from inner side" EXACT [] is_a: GO:0032978 ! protein insertion into membrane from inner side is_a: GO:0045039 ! protein insertion into mitochondrial inner membrane [Term] id: GO:0032980 name: keratinocyte activation namespace: biological_process def: "A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines." [GOC:mah, PMID:15737202] is_a: GO:0001775 ! cell activation [Term] id: GO:0032981 name: mitochondrial respiratory chain complex I assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I." [GOC:rph] synonym: "mitochondrial complex I assembly" EXACT [] synonym: "mitochondrial NADH dehydrogenase complex (ubiquinone) assembly" EXACT [] is_a: GO:0010257 ! NADH dehydrogenase complex assembly is_a: GO:0033108 ! mitochondrial respiratory chain complex assembly [Term] id: GO:0032982 name: myosin filament namespace: cellular_component def: "A protein complex containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament." [GOC:mah] synonym: "myosin thick filament" RELATED [] synonym: "thick filament" RELATED [] is_a: GO:0016459 ! myosin complex [Term] id: GO:0032983 name: kainate selective glutamate receptor complex namespace: cellular_component def: "An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits." [GOC:bf, http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html, PMID:18655795] is_a: GO:0008328 ! ionotropic glutamate receptor complex is_a: GO:0034705 ! potassium channel complex is_a: GO:0034706 ! sodium channel complex [Term] id: GO:0032984 name: protein-containing complex disassembly namespace: biological_process alt_id: GO:0034623 alt_id: GO:0043241 def: "The disaggregation of a protein-containing macromolecular complex into its constituent components." [GOC:mah] synonym: "cellular macromolecule complex disassembly" RELATED [] synonym: "macromolecule complex disassembly" RELATED [] synonym: "protein complex disassembly" EXACT [] is_a: GO:0022411 ! cellular component disassembly is_a: GO:0043933 ! protein-containing complex subunit organization [Term] id: GO:0032985 name: protein-carbohydrate complex disassembly namespace: biological_process def: "The disaggregation of a protein-carbohydrate complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071823 ! protein-carbohydrate complex subunit organization [Term] id: GO:0032986 name: protein-DNA complex disassembly namespace: biological_process def: "The disaggregation of a protein-DNA complex into its constituent components." [GOC:mah] synonym: "DNA-protein complex disassembly" EXACT [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071824 ! protein-DNA complex subunit organization [Term] id: GO:0032987 name: protein-lipid complex disassembly namespace: biological_process def: "The disaggregation of a protein-lipid complex into its constituent components." [GOC:mah] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071825 ! protein-lipid complex subunit organization [Term] id: GO:0032988 name: ribonucleoprotein complex disassembly namespace: biological_process def: "The disaggregation of a protein-RNA complex into its constituent components." [GOC:mah] synonym: "protein-RNA complex disassembly" EXACT [] synonym: "RNA-protein complex disassembly" EXACT [] synonym: "RNP complex disassembly" EXACT [] is_a: GO:0032984 ! protein-containing complex disassembly is_a: GO:0071826 ! ribonucleoprotein complex subunit organization [Term] id: GO:0032989 name: cellular component morphogenesis namespace: biological_process def: "The process in which cellular structures, including whole cells or cell parts, are generated and organized." [GOC:dph, GOC:mah, GOC:tb] subset: goslim_pir synonym: "cellular structure morphogenesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0016043 ! cellular component organization is_a: GO:0048869 ! cellular developmental process [Term] id: GO:0032990 name: cell part morphogenesis namespace: biological_process def: "The process in which the anatomical structures of a cell part are generated and organized." [GOC:mah] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0032991 name: protein-containing complex namespace: cellular_component alt_id: GO:0043234 def: "A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together." [GOC:dos, GOC:mah] comment: A protein complex in this context is meant as a stable set of interacting proteins which can be co-purified by an acceptable method, and where the complex has been shown to exist as an isolated, functional unit in vivo. Acceptable experimental methods include stringent protein purification followed by detection of protein interaction. The following methods should be considered non-acceptable: simple immunoprecipitation, pull-down experiments from cell extracts without further purification, colocalization and 2-hybrid screening. Interactions that should not be captured as protein complexes include: 1) enzyme/substrate, receptor/ligand or any similar transient interactions, unless these are a critical part of the complex assembly or are required e.g. for the receptor to be functional; 2) proteins associated in a pull-down/co-immunoprecipitation assay with no functional link or any evidence that this is a defined biological entity rather than a loose-affinity complex; 3) any complex where the only evidence is based on genetic interaction data; 4) partial complexes, where some subunits (e.g. transmembrane ones) cannot be expressed as recombinant proteins and are excluded from experiments (in this case, independent evidence is necessary to find out the composition of the full complex, if known). Interactions that may be captured as protein complexes include: 1) enzyme/substrate or receptor/ligand if the complex can only assemble and become functional in the presence of both classes of subunits; 2) complexes where one of the members has not been shown to be physically linked to the other(s), but is a homologue of, and has the same functionality as, a protein that has been experimentally demonstrated to form a complex with the other member(s); 3) complexes whose existence is accepted based on localization and pharmacological studies, but for which experimental evidence is not yet available for the complex as a whole. subset: goslim_agr subset: goslim_chembl subset: goslim_flybase_ribbon subset: goslim_generic subset: goslim_pir synonym: "macromolecular complex" EXACT [] synonym: "macromolecule complex" EXACT [] synonym: "protein complex" NARROW [] synonym: "protein containing complex" EXACT [] synonym: "protein-protein complex" NARROW [] is_a: GO:0005575 ! cellular_component [Term] id: GO:0032992 name: protein-carbohydrate complex namespace: cellular_component def: "A macromolecular complex containing separate protein and carbohydrate molecules. Separate in this context means not covalently bound to each other." [GOC:mah] comment: Macromolecular complexes in which the carbohydrate component is all covalently bound to protein are not considered protein carbohydrate complexes. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032993 name: protein-DNA complex namespace: cellular_component def: "A macromolecular complex containing both protein and DNA molecules." [GOC:mah] comment: Note that this term is intended to classify complexes that have DNA as one of the members of the complex, that is, the complex does not exist if DNA is not present. Protein complexes that interact with DNA e.g. transcription factor complexes should not be classified here. subset: goslim_pir synonym: "DNA-protein complex" EXACT [GOC:mah] is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032994 name: protein-lipid complex namespace: cellular_component def: "A macromolecular complex containing separate protein and lipid molecules. Separate in this context means not covalently bound to each other." [GOC:mah] comment: Macromolecular complexes in which the lipid component is all covalently bound to protein are not considered protein-lipid complexes. is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0032995 name: regulation of fungal-type cell wall biogenesis namespace: biological_process def: "Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of chitin- and beta-glucan-containing cell wall biogenesis" RELATED [GOC:mah] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:1903338 ! regulation of cell wall organization or biogenesis relationship: regulates GO:0009272 ! fungal-type cell wall biogenesis [Term] id: GO:0032996 name: Bcl3-Bcl10 complex namespace: cellular_component def: "A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus." [PMID:16280327] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0032997 name: Fc receptor complex namespace: cellular_component def: "A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin." [GOC:add, ISBN:0781735149] subset: goslim_pir synonym: "Fc-receptor complex" EXACT [] synonym: "FcR complex" EXACT [] synonym: "immunoglobulin receptor complex" BROAD [] is_a: GO:0098797 ! plasma membrane protein complex [Term] id: GO:0032998 name: Fc-epsilon receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE." [GOC:add, ISBN:0781735149] synonym: "FceRI complex" EXACT [] synonym: "IgE receptor complex" BROAD [] synonym: "immunoglobulin E receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0032999 name: Fc-alpha receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA." [GOC:add, ISBN:0781735149, PMID:12524384] synonym: "FcaRI complex" EXACT [] synonym: "IgA receptor complex" BROAD [] synonym: "immunoglobulin A receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033000 name: Fc-gamma receptor I complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] synonym: "FcgRI complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033001 name: Fc-gamma receptor III complex namespace: cellular_component def: "A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG." [GOC:add, ISBN:0781735149, PMID:11244038, PMID:12413532] synonym: "FcgRIII complex" EXACT [] synonym: "IgG receptor complex" BROAD [] synonym: "immunoglobulin G receptor complex" BROAD [] is_a: GO:0032997 ! Fc receptor complex [Term] id: GO:0033002 name: muscle cell proliferation namespace: biological_process def: "The expansion of a muscle cell population by cell division." [CL:0000187, GOC:mah] synonym: "myocyte proliferation" EXACT [] is_a: GO:0008283 ! cell population proliferation [Term] id: GO:0033003 name: regulation of mast cell activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002694 ! regulation of leukocyte activation relationship: regulates GO:0045576 ! mast cell activation [Term] id: GO:0033004 name: negative regulation of mast cell activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002695 ! negative regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation relationship: negatively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033005 name: positive regulation of mast cell activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation." [GOC:mah] is_a: GO:0002696 ! positive regulation of leukocyte activation is_a: GO:0033003 ! regulation of mast cell activation relationship: positively_regulates GO:0045576 ! mast cell activation [Term] id: GO:0033006 name: regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0033003 ! regulation of mast cell activation is_a: GO:0050776 ! regulation of immune response relationship: regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033007 name: negative regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "negative regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0033004 ! negative regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050777 ! negative regulation of immune response relationship: negatively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033008 name: positive regulation of mast cell activation involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response." [GOC:mah] synonym: "positive regulation of mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0033005 ! positive regulation of mast cell activation is_a: GO:0033006 ! regulation of mast cell activation involved in immune response is_a: GO:0050778 ! positive regulation of immune response relationship: positively_regulates GO:0002279 ! mast cell activation involved in immune response [Term] id: GO:0033009 name: nucleomorph namespace: cellular_component def: "A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively." [PMID:16760254] xref: Wikipedia:Nucleomorph is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044435 ! plastid part [Term] id: GO:0033010 name: paranodal junction namespace: cellular_component def: "A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath." [PMID:11395001, PMID:14630217] synonym: "axoglial septate junction" EXACT [MP:0010735] synonym: "paranodal axoglial junction" EXACT [PMID:18803321] synonym: "paranodal septate junction" EXACT [MP:0010735] is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0033011 name: perinuclear theca namespace: cellular_component def: "A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins." [PMID:17289678, PMID:8025156] is_a: GO:0005856 ! cytoskeleton is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0048471 ! perinuclear region of cytoplasm [Term] id: GO:0033012 name: porosome namespace: cellular_component def: "A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles." [PMID:15090256, PMID:16563225] xref: Wikipedia:Porosome is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0033013 name: tetrapyrrole metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033014 name: tetrapyrrole biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole anabolism" EXACT [] synonym: "tetrapyrrole biosynthesis" EXACT [] synonym: "tetrapyrrole formation" EXACT [] synonym: "tetrapyrrole synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033015 name: tetrapyrrole catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next." [CHEBI:26932, GOC:mah] synonym: "tetrapyrrole breakdown" EXACT [] synonym: "tetrapyrrole catabolism" EXACT [] synonym: "tetrapyrrole degradation" EXACT [] is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process is_a: GO:1901565 ! organonitrogen compound catabolic process [Term] id: GO:0033016 name: rhoptry membrane namespace: cellular_component def: "The lipid bilayer surrounding a rhoptry." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044464 ! cell part relationship: part_of GO:0020008 ! rhoptry [Term] id: GO:0033017 name: sarcoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005789 ! endoplasmic reticulum membrane is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033018 name: sarcoplasmic reticulum lumen namespace: cellular_component def: "The volume enclosed by the membranes of the sarcoplasmic reticulum." [GOC:rph] is_a: GO:0005788 ! endoplasmic reticulum lumen relationship: part_of GO:0016529 ! sarcoplasmic reticulum [Term] id: GO:0033019 name: 5-hydroxyvalerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5-hydroxyvalerate + NAD+ = 5-oxovalerate + NADH." [GOC:mlg, PMID:12406764] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0033020 name: cyclopentanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyclopentanol." [GOC:mlg, PMID:12406764] synonym: "cyclopentanol metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0033021 name: cyclopentanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclopentanol." [GOC:mah, PMID:12406764] synonym: "cyclopentanol anabolism" EXACT [] synonym: "cyclopentanol biosynthesis" EXACT [] synonym: "cyclopentanol formation" EXACT [] synonym: "cyclopentanol synthesis" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0046165 ! alcohol biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0033022 name: cyclopentanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclopentanol." [GOC:mah, PMID:12406764] synonym: "cyclopentanol breakdown" EXACT [] synonym: "cyclopentanol catabolism" EXACT [] synonym: "cyclopentanol degradation" EXACT [] is_a: GO:0033020 ! cyclopentanol metabolic process is_a: GO:0046164 ! alcohol catabolic process is_a: GO:1901361 ! organic cyclic compound catabolic process [Term] id: GO:0033023 name: mast cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:11292031] comment: Note that this term represents the return of mast cell levels to stable numbers following an immune response as well as the proliferation and elimination of mast cells required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0001776 ! leukocyte homeostasis is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0033024 name: mast cell apoptotic process namespace: biological_process def: "Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation." [CL:0000097, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:12360215, PMID:16605130] synonym: "apoptosis of mast cells" EXACT [] synonym: "mast cell apoptosis" NARROW [] is_a: GO:0033028 ! myeloid cell apoptotic process is_a: GO:0071887 ! leukocyte apoptotic process relationship: part_of GO:0033023 ! mast cell homeostasis [Term] id: GO:0033025 name: regulation of mast cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of mast cell apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0065008 ! regulation of biological quality is_a: GO:2000106 ! regulation of leukocyte apoptotic process relationship: regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033026 name: negative regulation of mast cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of mast cell apoptosis" EXACT [] synonym: "down-regulation of mast cell apoptosis" EXACT [] synonym: "downregulation of mast cell apoptosis" EXACT [] synonym: "inhibition of mast cell apoptosis" NARROW [] synonym: "negative regulation of mast cell apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process relationship: negatively_regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033027 name: positive regulation of mast cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of mast cell apoptosis" NARROW [] synonym: "positive regulation of mast cell apoptosis" NARROW [] synonym: "stimulation of mast cell apoptosis" NARROW [] synonym: "up regulation of mast cell apoptosis" EXACT [] synonym: "up-regulation of mast cell apoptosis" EXACT [] synonym: "upregulation of mast cell apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033025 ! regulation of mast cell apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process relationship: positively_regulates GO:0033024 ! mast cell apoptotic process [Term] id: GO:0033028 name: myeloid cell apoptotic process namespace: biological_process def: "Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage." [CL:0000763, GOC:add, GOC:mtg_apoptosis, PMID:11292031, PMID:15330259, PMID:17133093] synonym: "apoptosis of myeloid cells" EXACT [] synonym: "myeloid cell apoptosis" NARROW [] is_a: GO:0006915 ! apoptotic process [Term] id: GO:0033029 name: regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of neutrophil apoptosis" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0065008 ! regulation of biological quality is_a: GO:2000106 ! regulation of leukocyte apoptotic process relationship: regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033030 name: negative regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of neutrophil apoptosis" EXACT [] synonym: "down-regulation of neutrophil apoptosis" EXACT [] synonym: "downregulation of neutrophil apoptosis" EXACT [] synonym: "inhibition of neutrophil apoptosis" NARROW [] synonym: "negative regulation of neutrophil apoptosis" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033033 ! negative regulation of myeloid cell apoptotic process is_a: GO:2000107 ! negative regulation of leukocyte apoptotic process relationship: negatively_regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033031 name: positive regulation of neutrophil apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of neutrophil apoptosis" NARROW [] synonym: "positive regulation of neutrophil apoptosis" NARROW [] synonym: "stimulation of neutrophil apoptosis" NARROW [] synonym: "up regulation of neutrophil apoptosis" EXACT [] synonym: "up-regulation of neutrophil apoptosis" EXACT [] synonym: "upregulation of neutrophil apoptosis" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0033029 ! regulation of neutrophil apoptotic process is_a: GO:0033034 ! positive regulation of myeloid cell apoptotic process is_a: GO:2000108 ! positive regulation of leukocyte apoptotic process relationship: positively_regulates GO:0001781 ! neutrophil apoptotic process [Term] id: GO:0033032 name: regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0042981 ! regulation of apoptotic process relationship: regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033033 name: negative regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "down regulation of myeloid cell apoptosis" EXACT [] synonym: "down-regulation of myeloid cell apoptosis" EXACT [] synonym: "downregulation of myeloid cell apoptosis" EXACT [] synonym: "inhibition of myeloid cell apoptosis" NARROW [] synonym: "negative regulation of myeloid cell apoptosis" NARROW [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043066 ! negative regulation of apoptotic process relationship: negatively_regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033034 name: positive regulation of myeloid cell apoptotic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process." [GOC:add, GOC:mtg_apoptosis] synonym: "activation of myeloid cell apoptosis" NARROW [] synonym: "positive regulation of myeloid cell apoptosis" NARROW [] synonym: "stimulation of myeloid cell apoptosis" NARROW [] synonym: "up regulation of myeloid cell apoptosis" EXACT [] synonym: "up-regulation of myeloid cell apoptosis" EXACT [] synonym: "upregulation of myeloid cell apoptosis" EXACT [] is_a: GO:0033032 ! regulation of myeloid cell apoptotic process is_a: GO:0043065 ! positive regulation of apoptotic process relationship: positively_regulates GO:0033028 ! myeloid cell apoptotic process [Term] id: GO:0033036 name: macromolecule localization namespace: biological_process def: "Any process in which a macromolecule is transported to, or maintained in, a specific location." [GOC:mah] subset: goslim_flybase_ribbon synonym: "macromolecule localisation" EXACT [GOC:mah] is_a: GO:0051179 ! localization [Term] id: GO:0033037 name: polysaccharide localization namespace: biological_process def: "Any process in which a polysaccharide is transported to, or maintained in, a specific location." [GOC:mah] synonym: "polysaccharide localisation" EXACT [GOC:mah] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0033038 name: bitter taste receptor activity namespace: molecular_function def: "Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033039 name: salty taste receptor activity namespace: molecular_function def: "Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033040 name: sour taste receptor activity namespace: molecular_function def: "Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033041 name: sweet taste receptor activity namespace: molecular_function def: "Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste." [GOC:mah] is_a: GO:0008527 ! taste receptor activity [Term] id: GO:0033042 name: umami taste receptor activity namespace: molecular_function def: "Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates." [GOC:mah] is_a: GO:0090681 ! GPCR taste receptor activity [Term] id: GO:0033043 name: regulation of organelle organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle." [GOC:mah] subset: goslim_yeast synonym: "regulation of organelle organisation" EXACT [GOC:mah] synonym: "regulation of organelle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0051128 ! regulation of cellular component organization relationship: regulates GO:0006996 ! organelle organization [Term] id: GO:0033044 name: regulation of chromosome organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome." [GOC:mah] synonym: "regulation of chromosome organisation" EXACT [GOC:mah] synonym: "regulation of chromosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0033043 ! regulation of organelle organization relationship: regulates GO:0051276 ! chromosome organization [Term] id: GO:0033045 name: regulation of sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation relationship: regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033046 name: negative regulation of sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation." [GOC:mah] is_a: GO:0010948 ! negative regulation of cell cycle process is_a: GO:0033045 ! regulation of sister chromatid segregation is_a: GO:0051985 ! negative regulation of chromosome segregation is_a: GO:2001251 ! negative regulation of chromosome organization relationship: negatively_regulates GO:0000819 ! sister chromatid segregation [Term] id: GO:0033047 name: regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0007088 ! regulation of mitotic nuclear division is_a: GO:0033045 ! regulation of sister chromatid segregation relationship: regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033048 name: negative regulation of mitotic sister chromatid segregation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis." [GOC:mah] is_a: GO:0033046 ! negative regulation of sister chromatid segregation is_a: GO:0033047 ! regulation of mitotic sister chromatid segregation is_a: GO:0045839 ! negative regulation of mitotic nuclear division relationship: negatively_regulates GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0033049 name: clavulanic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah] synonym: "clavulanic acid metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033050 name: clavulanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid." [CHEBI:3736, GOC:mah] synonym: "clavulanic acid anabolism" EXACT [] synonym: "clavulanic acid biosynthesis" EXACT [] synonym: "clavulanic acid formation" EXACT [] synonym: "clavulanic acid synthesis" EXACT [] xref: Wikipedia:Clavulanic_acid is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033049 ! clavulanic acid metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0072330 ! monocarboxylic acid biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033051 name: aminophosphonate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group." [GOC:mah, http://pages.unibas.ch/mdpi/ecsoc/a0045/a0045.htm, KEGG:map00440] synonym: "aminophosphonate metabolism" EXACT [] is_a: GO:0019634 ! organic phosphonate metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033052 name: cyanoamino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group." [GOC:mah, PMID:11575729] synonym: "cyanoamino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0050898 ! nitrile metabolic process [Term] id: GO:0033053 name: D-glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid." [CHEBI:17061, GOC:jsg, GOC:mah] synonym: "D-glutamine metabolism" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033054 name: D-glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid." [CHEBI:15966, GOC:jsg, GOC:mah] synonym: "D-glutamate metabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033055 name: D-arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid." [CHEBI:15816, GOC:jsg, GOC:mah] synonym: "D-arginine metabolism" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process [Term] id: GO:0033056 name: D-ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid." [CHEBI:16176, GOC:jsg, GOC:mah] synonym: "D-ornithine metabolism" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0046144 ! D-alanine family amino acid metabolic process is_a: GO:0046416 ! D-amino acid metabolic process is_a: GO:0097164 ! ammonium ion metabolic process [Term] id: GO:0033058 name: directional locomotion namespace: biological_process def: "Self-propelled movement of a cell or organism from one location to another along an axis." [GOC:mtg_MIT_16mar07] is_a: GO:0040011 ! locomotion [Term] id: GO:0033059 name: cellular pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in a cell." [GOC:mtg_MIT_16mar07] is_a: GO:0009987 ! cellular process is_a: GO:0043473 ! pigmentation [Term] id: GO:0033060 name: ocellus pigmentation namespace: biological_process def: "The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates." [GOC:mtg_MIT_16mar07] is_a: GO:0043473 ! pigmentation [Term] id: GO:0033061 name: DNA recombinase mediator complex namespace: cellular_component def: "A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA." [GOC:elh, GOC:mah, GOC:vw, InterPro:IPR003488, PMID:12912992] comment: Many paralogs of Rad51 act as recombinase mediators. These paralogs dimerize (or occasionally form tetramers) amongst themselves to form complexes with ssDNA-binding activity, and which act as mediators of Rad51 presynaptic filament assembly. subset: goslim_pir is_a: GO:0032991 ! protein-containing complex [Term] id: GO:0033062 name: Rhp55-Rhp57 complex namespace: cellular_component def: "A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces)." [GOC:mah, GOC:vw] synonym: "Rad55-Rad57 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033063 name: Rad51B-Rad51C-Rad51D-XRCC2 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BCDX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033064 name: XRCC2-RAD51D complex namespace: cellular_component def: "A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast." [GOC:mah, GOC:vw, PMID:16093548] synonym: "DX2 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033065 name: Rad51C-XRCC3 complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "CX3 complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033066 name: Rad51B-Rad51C complex namespace: cellular_component def: "A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof." [GOC:mah, PMID:16093548, PMID:17114795] synonym: "BC complex" EXACT [] is_a: GO:0033061 ! DNA recombinase mediator complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0033067 name: macrolide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] synonym: "macrolide metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:1901334 ! lactone metabolic process [Term] id: GO:0033068 name: macrolide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria." [ISBN:0198506732, PMID:17298179] synonym: "macrolide anabolism" EXACT [] synonym: "macrolide biosynthesis" EXACT [] synonym: "macrolide formation" EXACT [] synonym: "macrolide synthesis" EXACT [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033067 ! macrolide metabolic process is_a: GO:1901336 ! lactone biosynthetic process [Term] id: GO:0033069 name: ansamycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] synonym: "ansamycin metabolism" EXACT [] is_a: GO:0016999 ! antibiotic metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process is_a: GO:1901564 ! organonitrogen compound metabolic process [Term] id: GO:0033070 name: ansamycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity." [GOC:mah, http://ww2.icho.edu.pl/cednets/rydzyna/meyer.htm] synonym: "ansamycin anabolism" EXACT [] synonym: "ansamycin biosynthesis" EXACT [] synonym: "ansamycin formation" EXACT [] synonym: "ansamycin synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0033069 ! ansamycin metabolic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process is_a: GO:1901566 ! organonitrogen compound biosynthetic process [Term] id: GO:0033071 name: vancomycin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah] synonym: "vancomycin metabolism" EXACT [] is_a: GO:0030650 ! peptide antibiotic metabolic process is_a: GO:1901135 ! carbohydrate derivative metabolic process [Term] id: GO:0033072 name: vancomycin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria." [CHEBI:28001, GOC:mah] synonym: "vancomycin anabolism" EXACT [] synonym: "vancomycin biosynthesis" EXACT [] synonym: "vancomycin formation" EXACT [] synonym: "vancomycin synthesis" EXACT [] is_a: GO:0019184 ! nonribosomal peptide biosynthetic process is_a: GO:0030651 ! peptide antibiotic biosynthetic process is_a: GO:0033071 ! vancomycin metabolic process is_a: GO:1901137 ! carbohydrate derivative biosynthetic process [Term] id: GO:0033073 name: pinene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] synonym: "pinene metabolism" EXACT [] is_a: GO:0043692 ! monoterpene metabolic process [Term] id: GO:0033074 name: pinene catabolic process namespace: biological_process def: "The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane." [GOC:mah, http://www.chem.qmul.ac.uk/iubmb/enzyme/glossary/pinene.html] synonym: "pinene breakdown" EXACT [] synonym: "pinene catabolism" EXACT [] synonym: "pinene degradation" EXACT [] is_a: GO:0033073 ! pinene metabolic process is_a: GO:0043694 ! monoterpene catabolic process [Term] id: GO:0033075 name: isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] synonym: "ipecac alkaloid biosynthesis" RELATED [] synonym: "isoquinoline alkaloid anabolism" EXACT [] synonym: "isoquinoline alkaloid biosynthesis" EXACT [] synonym: "isoquinoline alkaloid formation" EXACT [] synonym: "isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0033076 ! isoquinoline alkaloid metabolic process is_a: GO:1901362 ! organic cyclic compound biosynthetic process [Term] id: GO:0033076 name: isoquinoline alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin." [GOC:mah, http://www.life.uiuc.edu/ib/425/lecture32.html] synonym: "ipecac alkaloid metabolism" RELATED [] synonym: "isoquinoline alkaloid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:1901360 ! organic cyclic compound metabolic process [Term] id: GO:0033077 name: T cell differentiation in thymus namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "T cell development in thymus" RELATED [GOC:add] synonym: "thymic T cell differentiation" EXACT [] synonym: "thymocyte cell differentiation" EXACT [] synonym: "thymocyte differentiation" EXACT [] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033078 name: extrathymic T cell differentiation namespace: biological_process def: "The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus." [GOC:add, ISBN:0781735149] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "extrathymic T cell development" RELATED [GOC:add] is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0033079 name: immature T cell proliferation namespace: biological_process def: "The expansion of an immature T cell population by cell division." [GOC:add, ISBN:0781735149] is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0033080 name: immature T cell proliferation in thymus namespace: biological_process def: "The expansion of an immature T cell population by cell division in the thymus." [GOC:add, ISBN:0781735149] synonym: "thymic T cell proliferation" EXACT [] synonym: "thymocyte cell proliferation" EXACT [] synonym: "thymocyte proliferation" EXACT [] is_a: GO:0033079 ! immature T cell proliferation relationship: part_of GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033081 name: regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of T cell development in thymus" RELATED [GOC:add] synonym: "regulation of thymic T cell differentiation" EXACT [] synonym: "regulation of thymocyte cell differentiation" EXACT [] synonym: "regulation of thymocyte differentiation" EXACT [] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033082 name: regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0045580 ! regulation of T cell differentiation relationship: regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033083 name: regulation of immature T cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0042129 ! regulation of T cell proliferation relationship: regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033084 name: regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "regulation of thymic T cell proliferation" EXACT [] synonym: "regulation of thymocyte cell proliferation" EXACT [] synonym: "regulation of thymocyte proliferation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0033083 ! regulation of immature T cell proliferation relationship: regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033085 name: negative regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of T cell development in thymus" RELATED [GOC:add] synonym: "negative regulation of thymic T cell differentiation" EXACT [] synonym: "negative regulation of thymocyte cell differentiation" EXACT [] synonym: "negative regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045581 ! negative regulation of T cell differentiation relationship: negatively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033086 name: negative regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "negative regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045581 ! negative regulation of T cell differentiation relationship: negatively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033087 name: negative regulation of immature T cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042130 ! negative regulation of T cell proliferation relationship: negatively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033088 name: negative regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "negative regulation of thymic T cell proliferation" EXACT [] synonym: "negative regulation of thymocyte cell proliferation" EXACT [] synonym: "negative regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033085 ! negative regulation of T cell differentiation in thymus is_a: GO:0033087 ! negative regulation of immature T cell proliferation relationship: negatively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033089 name: positive regulation of T cell differentiation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of T cell development in thymus" RELATED [GOC:add] synonym: "positive regulation of thymic T cell differentiation" EXACT [] synonym: "positive regulation of thymocyte cell differentiation" EXACT [] synonym: "positive regulation of thymocyte differentiation" EXACT [] is_a: GO:0033081 ! regulation of T cell differentiation in thymus is_a: GO:0045582 ! positive regulation of T cell differentiation relationship: positively_regulates GO:0033077 ! T cell differentiation in thymus [Term] id: GO:0033090 name: positive regulation of extrathymic T cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation." [GOC:add, GOC:mah] comment: Note that immunologists typically use the word 'development' to refer to cells of B or T cell lineages undergoing the process that GO describes as 'cell differentiation'. synonym: "positive regulation of extrathymic T cell development" RELATED [GOC:add] is_a: GO:0033082 ! regulation of extrathymic T cell differentiation is_a: GO:0045582 ! positive regulation of T cell differentiation relationship: positively_regulates GO:0033078 ! extrathymic T cell differentiation [Term] id: GO:0033091 name: positive regulation of immature T cell proliferation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation." [GOC:add, GOC:mah] is_a: GO:0033083 ! regulation of immature T cell proliferation is_a: GO:0042102 ! positive regulation of T cell proliferation relationship: positively_regulates GO:0033079 ! immature T cell proliferation [Term] id: GO:0033092 name: positive regulation of immature T cell proliferation in thymus namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus." [GOC:add, GOC:mah] synonym: "positive regulation of thymic T cell proliferation" EXACT [] synonym: "positive regulation of thymocyte cell proliferation" EXACT [] synonym: "positive regulation of thymocyte proliferation" EXACT [] is_a: GO:0033084 ! regulation of immature T cell proliferation in thymus is_a: GO:0033089 ! positive regulation of T cell differentiation in thymus is_a: GO:0033091 ! positive regulation of immature T cell proliferation relationship: positively_regulates GO:0033080 ! immature T cell proliferation in thymus [Term] id: GO:0033093 name: Weibel-Palade body namespace: cellular_component def: "A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses." [PMID:11935287, PMID:16087708] xref: Wikipedia:Weibel-Palade_body is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0030141 ! secretory granule [Term] id: GO:0033094 name: butane-1,4-diamine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: putrescine + 2-oxoglutarate = L-glutamate + 1-pyrroline + H2O." [EC:2.6.1.82, GOC:mlg] synonym: "PAT activity" RELATED [] synonym: "putrescine aminotransferase activity" BROAD [EC:2.6.1.82] synonym: "putrescine transaminase activity" BROAD [] synonym: "putrescine-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "putrescine:alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.82] synonym: "YgjG" RELATED [EC:2.6.1.82] xref: EC:2.6.1.82 xref: MetaCyc:2.6.1.82-RXN xref: RHEA:24655 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0033095 name: aleurone grain namespace: cellular_component def: "A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes." [http://ejournal.sinica.edu.tw/bbas/content/2004/1/bot451-08.pdf, http://www.springerlink.com/content/q7183h5vr7358278/] synonym: "aleurone body" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033096 name: amyloplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0033097 name: amyloplast membrane namespace: cellular_component def: "Either of the lipid bilayers that surround an amyloplast and form the amyloplast envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033096 ! amyloplast envelope [Term] id: GO:0033098 name: amyloplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma." [GOC:ecd] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0033097 ! amyloplast membrane [Term] id: GO:0033099 name: attachment organelle namespace: cellular_component def: "A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division." [http://authors.library.caltech.edu/3529/, PMID:11325545, PMID:12003948] subset: goslim_pir is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0033100 name: NuA3 histone acetyltransferase complex namespace: cellular_component def: "A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p." [PMID:10817755, PMID:17157260] is_a: GO:0070775 ! H3 histone acetyltransferase complex [Term] id: GO:0033101 name: cellular bud membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a cellular bud." [GOC:mah] synonym: "cellular bud plasma membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0033102 name: acidocalcisome membrane namespace: cellular_component def: "The lipid bilayer surrounding an acidocalcisome." [GOC:ecd, PMID:11378195] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0020022 ! acidocalcisome [Term] id: GO:0033103 name: protein secretion by the type VI secretion system namespace: biological_process def: "The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] comment: Note that this term represents an activity and not a cellular structure. Consider also annotating to the cellular component term 'type VI protein secretion system complex ; GO:0033104'. synonym: "protein secretion by the T6SS" EXACT [] synonym: "protein secretion by the type VI protein secretion system" EXACT [] synonym: "type VI protein secretion system" EXACT [] is_a: GO:0009306 ! protein secretion is_a: GO:0071806 ! protein transmembrane transport [Term] id: GO:0033104 name: type VI protein secretion system complex namespace: cellular_component def: "A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence." [GOC:mlg, PMID:16432199, PMID:16763151] synonym: "T6SS complex" EXACT [] is_a: GO:0032991 ! protein-containing complex is_a: GO:0044464 ! cell part [Term] id: GO:0033105 name: chlorosome envelope namespace: cellular_component def: "The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome." [PMID:14507718, PMID:14729689, PMID:17303128] comment: Note that the chlorosome envelope is not a single or double lipid bilayer, so this term is not a child of 'organelle membrane ; GO:0031090' or 'organelle envelope ; GO:0031967'. synonym: "chlorosome membrane" EXACT [] is_a: GO:0034646 ! organelle-enclosing lipid monolayer relationship: part_of GO:0046858 ! chlorosome [Term] id: GO:0033106 name: cis-Golgi network membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments that make up the cis-Golgi network." [GOC:mah] synonym: "cis Golgi network membrane" EXACT [] synonym: "Golgi cis face membrane" RELATED [] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005801 ! cis-Golgi network [Term] id: GO:0033107 name: Cvt vesicle namespace: cellular_component def: "A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p)." [GOC:rb, PMID:15138258] synonym: "cytoplasm to vacuole targeting vesicle" EXACT [] synonym: "cytoplasm-to-vacuole targeting vesicle" EXACT [] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033108 name: mitochondrial respiratory chain complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex." [GOC:mah] is_a: GO:0034622 ! cellular protein-containing complex assembly relationship: part_of GO:0007005 ! mitochondrion organization [Term] id: GO:0033110 name: Cvt vesicle membrane namespace: cellular_component def: "Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway." [GOC:ecd, PMID:20065092] synonym: "cytoplasm to vacuole targeting vesicle membrane" EXACT [] synonym: "cytoplasm-to-vacuole targeting vesicle membrane" EXACT [] is_a: GO:0030659 ! cytoplasmic vesicle membrane relationship: part_of GO:0033107 ! Cvt vesicle [Term] id: GO:0033111 name: attachment organelle membrane namespace: cellular_component def: "The lipid bilayer surrounding an attachment organelle. This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane." [GOC:ecd] is_a: GO:0044424 ! intracellular part is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098589 ! membrane region relationship: part_of GO:0033099 ! attachment organelle [Term] id: GO:0033112 name: cyanelle envelope namespace: cellular_component def: "The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:mah] is_a: GO:0009526 ! plastid envelope relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0033113 name: cyanelle membrane namespace: cellular_component def: "Either of the lipid bilayers that surround a cyanelle and form the cyanelle envelope." [GOC:ecd] is_a: GO:0042170 ! plastid membrane relationship: part_of GO:0033112 ! cyanelle envelope [Term] id: GO:0033114 name: cyanelle thylakoid lumen namespace: cellular_component def: "The volume enclosed by a cyanelle thylakoid membrane." [GOC:mah] is_a: GO:0031978 ! plastid thylakoid lumen relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033115 name: cyanelle thylakoid membrane namespace: cellular_component def: "The lipid bilayer membrane of any thylakoid within a cyanelle." [GOC:mah] is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009843 ! cyanelle thylakoid [Term] id: GO:0033116 name: endoplasmic reticulum-Golgi intermediate compartment membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system." [GOC:mah, GOC:pr, PMID:16723730] synonym: "ER-Golgi intermediate compartment membrane" EXACT [] is_a: GO:0044444 ! cytoplasmic part is_a: GO:0098588 ! bounding membrane of organelle relationship: part_of GO:0005793 ! endoplasmic reticulum-Golgi intermediate compartment [Term] id: GO:0033117 name: esterosome namespace: cellular_component def: "A vesicle filled with crystalline protein that shows sequence similarities with various esterases." [GOC:ecd, PMID:2307702] is_a: GO:0031410 ! cytoplasmic vesicle [Term] id: GO:0033118 name: esterosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes." [GOC:ecd, PMID:2307702] is_a: GO:0030659 ! cytoplasmic vesicle membrane is_a: GO:0098588 ! bounding membrane of organelle is_a: GO:0098805 ! whole membrane relationship: part_of GO:0033117 ! esterosome [Term] id: GO:0033119 name: negative regulation of RNA splicing namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051253 ! negative regulation of RNA metabolic process relationship: negatively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033120 name: positive regulation of RNA splicing namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of RNA splicing." [GOC:mah] is_a: GO:0010628 ! positive regulation of gene expression is_a: GO:0043484 ! regulation of RNA splicing is_a: GO:0051254 ! positive regulation of RNA metabolic process relationship: positively_regulates GO:0008380 ! RNA splicing [Term] id: GO:0033121 name: regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "regulation of purine nucleotide breakdown" EXACT [] synonym: "regulation of purine nucleotide catabolism" EXACT [] synonym: "regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030811 ! regulation of nucleotide catabolic process is_a: GO:1900542 ! regulation of purine nucleotide metabolic process relationship: regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033122 name: negative regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "negative regulation of purine nucleotide breakdown" EXACT [] synonym: "negative regulation of purine nucleotide catabolism" EXACT [] synonym: "negative regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030812 ! negative regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900543 ! negative regulation of purine nucleotide metabolic process relationship: negatively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033123 name: positive regulation of purine nucleotide catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides." [GOC:mah] synonym: "positive regulation of purine nucleotide breakdown" EXACT [] synonym: "positive regulation of purine nucleotide catabolism" EXACT [] synonym: "positive regulation of purine nucleotide degradation" EXACT [] is_a: GO:0030813 ! positive regulation of nucleotide catabolic process is_a: GO:0033121 ! regulation of purine nucleotide catabolic process is_a: GO:1900544 ! positive regulation of purine nucleotide metabolic process relationship: positively_regulates GO:0006195 ! purine nucleotide catabolic process [Term] id: GO:0033124 name: obsolete regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "regulation of GTP breakdown" EXACT [] synonym: "regulation of GTP catabolism" EXACT [] synonym: "regulation of GTP degradation" EXACT [] is_obsolete: true consider: GO:0043087 [Term] id: GO:0033125 name: obsolete negative regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small molecule. We found no cases where these molecules genuinely underwent catabolism. synonym: "negative regulation of GTP breakdown" EXACT [] synonym: "negative regulation of GTP catabolism" EXACT [] synonym: "negative regulation of GTP degradation" EXACT [] is_obsolete: true consider: GO:0034260 [Term] id: GO:0033126 name: obsolete positive regulation of GTP catabolic process namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [GOC:mah] comment: The reason for making this term obsolete is that it gets misused in cases where phosphates are simply being removed from a small m